La Mittel- Osteuropa constitue à la fois un espace géographique et une construction historico-culturelle. Cet espace est formé de plusieurs pays qui ont appartenu à l'empire austro-hongrois et dont la religion catholique majoritaire représente un critère d'unité.La catholicité de cet espace justifie l'intérêt que le Saint-Siège porte à la plupart de ces pays qui deviendront après 1945 des satellites de l'Union soviétique. Les régimes d'inspiration communiste combattront l'autorité spirituelle de Rome, exerceront le contrôle de la vie religieuse et restreindront ainsi les libertés confessionnelles.Face à cette politique antireligieuse et à ce contrôle étroit de la sphère religieuse, le Saint-Siège se devait de réagir et de développer une stratégie de contre-offensive. Dans cette optique, l'Autriche a joué un rôle important dans les orientations de politique étrangère et religieuse du Vatican. Le pays avait encore de nombreux contacts avec les anciens pays de la monarchie des Habsbourg dont la fin était relativement proche. Par ailleurs, Vienne occupe une position avancée en Europe centrale. L'expérience centre-européenne riche de l'Autriche tant sur un plan culturel que linguistique représentait un bien précieux pour la Rome papale, pour qui Vienne pouvait servir de porte d'entrée vers la Mittel- Osteuropa.Le pape Pie XII a parlé d'une mission historique de l'Autriche qui sera considérée comme un phare catholique face à un océan marxiste athée. Malgré cette identité d'intérêts, les relations entre l'Autriche et le Vatican n'ont pas été exemptes de tensions, particulièrement à cause de la controverse sur la remise en vigueur du concordat de 1933. La question du mariage devient un élément de crispation, d'autant plus que la société autrichienne de l'après-guerre était déjà plus sécularisée que celle de l'entre-deux-guerres.L'Autriche saura tirer des avantages spécifiques de la neutralité qui lui a été imposée en échange de sa souveraineté retrouvée. La « neutralité active » va lui permettre de mettre en œuvre une Ostpolitik dans laquelle l'Eglise prendra une place importante qui apparait clairement dans différents exemples : le voyage d'un théologien de l'université de Graz en Union soviétique en 1955, et plus tard les visites du cardinal Franz König aux épiscopats derrière le rideau de fer mais aussi la création de la fondation Pro Oriente en 1964.La guerre froide fut avant tout un conflit idéologique entre deux systèmes très différents tant sur le plan social que politique et économique, avec le capitalisme ou le libéralisme d'une part, et le communisme ou le socialisme d'autre part. En outre, un autre conflit idéologique est aussi apparu entre le catholicisme romain et le communisme athée, deux systèmes de pensée totalement opposés. Le Saint-Siège devint alors un acteur de la guerre froide. Pie XII défendait l'idée que « le communisme est intrinsèquement pervers et l'on ne peut admettre sur aucun terrain de collaboration avec lui ». Pourtant, il existait par la force des choses des relations entre les communistes et l'Eglise catholique dans les pays situés derrière le « rideau de fer ».La Curie romaine n'était pas toute entière hostile au dialogue avec les communistes. Abstraction faite d'un climat d'intransigeance doctrinale, il se trouvait aussi des prélats qui pensaient que toutes les portes du dialogue ne devaient pas rester irrémédiablement fermées. Les années d'après-guerre renvoient aussi à une période de renouvellement de la pensée chrétienne sur les plans philosophique, théologique et social. Les tendances à l'ouverture, annonciatrices d'un « printemps religieux », se heurtaient toutefois à la raideur dogmatique de la Curie romaine sous Pie XII.Les rapports des ambassadeurs autrichiens au Saint-Siège de 1946 à 1958/61 fournissent des informations précieuses sur les grandes thématiques du conflit Est-Ouest, qui touchaient d'une part les relations entre le Vatican et l'Autriche, et d'autre part le Vatican / Mittel- and Osteuropa form a geographic region and also a historical and cultural construct. This area consists of several countries that were part of the Austro-Hungarian Monarchy. Their predominant Catholic religion represented a criterion of unity.The Catholic character of this region justifies the interest which the Holy See had in the majority of these countries that became, after 1945, satellite states of the Soviet Union. The regimes shaped by the ideology of communism fought against the spiritual supremacy of Rome, control religious life and thus limit the denominational freedoms.The Holy See reacted to these anticlerical policies and to the rigid control over religious spheres by developing counter-strategies. In this respect, Austria has played an important role in conception of the foreign and church policies of the Vatican. It still had numerous contacts in the countries of the former Austro-Hungarian Monarchy, which had ended not such a long time ago. Vienna had a leading role in Central Europe. Austria's numerous cultural and linguistic experiences in Central Europe represented a treasure to Papal Rome intending to use Vienna as a door opener towards Mittel- Osteuropa .Pope Pius XII spoke of Austria's historic mission, which was considered the flagship Catholic country against the "atheist" and "Marxist ocean". Despite this identity of interests, relations between Austria and the Vatican were not free of tensions, particularly due to the controversy of entry into force of the Concordat of 1933. The question of marriage was another disturbing factor, since the post-war Austrian society was already more secularized than the interwar period society.Austria took specific advantages of the neutrality, which it had acquired in exchange for the regained sovereignty as an obligation. The "active neutrality" allowed an Ostpolitik in which the Catholic Church occupied an important place, which became clear by the examples of the journey of a theologian at the University of Graz in the Soviet Union in 1955, much later by the visits of Cardinal Franz König at the episcopates behind the Iron Curtain, but also by the creation of the Pro-Oriente Foundation in 1964.The Cold War was primarily an ideological system conflict between two very different social, political and economic camps, capitalism or liberalism on the one hand and communism or socialism on the other. In addition, there was the ideological conflict between Roman Catholicism and the atheistic Marxism - two completely opposite doctrines. The Holy See became a actor in the Cold War. Pius XII advocated the view that “Communism is intrinsically wrong, and no one may collaborate with it in any undertaking whatsoever”. Nevertheless, there were inevitably relations between the Communists and the Catholic Church in the countries behind the "Iron Curtain".The Roman Curia was not unanimously against a dialogue with the Communists either. Apart from a doctrinal intransigence there were prelates who had the opinion that not all doors of dialogue should be closed. The post-war years also reflect a renewal period of Christian thought on a philosophical, theological and social level. These opening trends, - signs of a future "religious spring" -, however, encountered the resistance and the dogmatic rigidity of the Papal Curia under Pope Pius XII.The Austrian ambassadors' reports to the Holy See from 1946 to 1958/61 provide valuable information about the major themes of the East-West conflict, that concerned, on the one hand, the relations between the Holy See and Austria, and on the other hand the Vatican and its relationship with Mittelosteuropa. The analysis and presentation of the reports form the basis of this work and examine the view of the Vatican not only on Austria but also on Mittelosteuropa during this politically highly tense period. The arrival of John XXIII as Pope in 1958 opens a new chapter of the Church in the Cold War. The Holy See turned into an a

In many organisms, the most fundamental event during embryogenesis is differentiating between germline cells and specialized somatic cells. In C. elegans, PIE-1 functions to protect the germline from somatic differentiation and appears to do so by blocking transcription and by preventing chromatin remodeling in the germline during early embryogenesis. Yet the molecular mechanisms by which PIE-1 specifies germline remain poorly understood. Our work shows that SUMOylation facilitates PIE-1-dependent germline maintenance and specification. In vivo SUMO purification in various CRISPR strains revealed that PIE-1 is SUMOylated at lysine 68 in the germline and that this SUMOylation is essential for forming NuRD complex and preserving HDA-1 activity. Moreover, HDA-1 SUMOylation is dependent on PIE-1 and enhanced by PIE-1 SUMOylation, which is required for protecting germline integrity. Our results suggest the importance of SUMOylation in the germline maintenance and exemplify simultaneous SUMOylation of proteins in the same functional pathway.

CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior / O tratamento da informaÃÃo à importante para a formaÃÃo do cidadÃo, pois estamos cercados de dados e fatos que precisam ser compreendidos. Contudo, avaliaÃÃes recentes do Sistema de AvaliaÃÃo da EducaÃÃo BÃsica (SAEB) e do Instituto Nacional de Alfabetismo Funcional (INAF) indicam as dificuldades de estudantes e atà de adultos das diversas regiÃes do paÃs, apresentam no entendimento da representaÃÃo de dados em grÃficos e em tabelas e em compreender os conceitos matemÃticos envolvidos. Pesquisas revelam que o estudo de grÃficos atravÃs de recursos tecnolÃgicos como computador e tecnologias digitais, favorece o desenvolvimento da aprendizagem de conceitos estatÃsticos, pois, na maioria das vezes, auxiliam a visualizaÃÃo e a exploraÃÃo de um conjunto de atividades, propiciando novas formas de pensar e agir. Dessa forma, realizou-se uma intervenÃÃo com um conjunto de atividades baseada no uso de objetos de aprendizagem (OA), a fim de verificar como o uso de tecnologias digitais contribui na aprendizagem de conceitos envolvidos no tratamento da informaÃÃo como construÃÃo e interpretaÃÃo de grÃficos de barras e de setores. A pesquisa foi realizada em uma escola pÃblica municipal de Fortaleza participante do Projeto Um Computador por Aluno - UCA, com duas turmas do 5 ano do Ensino Fundamental, com 26 alunos em cada uma. As turmas foram divididas em: Grupo Controle (GC) e Grupo Experimental (GE). A investigaÃÃo foi dividida em trÃs etapas: prÃ-teste, intervenÃÃo e pÃs-teste. Todos os alunos participaram do prÃ-teste e do pÃs-teste, aplicados individualmente e sem uso do computador. Todavia, ao GC nÃo foi ministrado nenhuma instruÃÃo formal alÃm da recebida em sala de aula. O GE foi submetido à intervenÃÃo que contemplou: aspectos matemÃticos de grÃficos e tabela, situaÃÃes-problema com classificaÃÃo e proporcionalidade e atividades de investigaÃÃo. Os dados foram analisados de modo a conhecer e compreender o desempenho dos alunos antes e apÃs as atividades, a evoluÃÃo de estratÃgias e o tratamento da informaÃÃo. Os estudantes que foram submetidos à intervenÃÃo apresentaram, estatisticamente, um desempenho superior quando comparado aos estudantes do GC. Constatou-se a evoluÃÃo das estratÃgias das crianÃas do GE, a partir de atividades desenvolvidas durante pesquisa. Essas atividades proporcionaram a integraÃÃo das diferentes tecnologias existentes na escola ao currÃculo escolar (laptop, tecnologias digitais e analÃgicas). Assim, o uso de tecnologias digitais permitiu a vivÃncia de experiÃncias didÃticas de tratamento da informaÃÃo das quais possibilitou: visualizar e simular diferentes situaÃÃes (representaÃÃo de grÃficos diferentes, de coleta e anÃlise de dados); tratar a informaÃÃo; trabalhar com situaÃÃes reais e com contextos investigativos e explorar os dados produzidos. Logo, os resultados deste estudo contribuem para melhor compreender a aprendizagem de grÃficos, assim como para o desenvolvimento de novos recursos e atividades. / The information processing is important for the citizen formation, since we are surrounded by data and facts that need to be understood. However, recent evaluations such as SAEB and INAF indicated the difficulties that children and adults from several Brazilian regions have been in the understanding of the processes related to data representation in graphs and tables, as well as understand involved mathematical concepts. Research have showed that the study of graphs by using of technological devices such as computer and another digital technologies, favoring the development of statistical concepts learning since these strategies help the visualization and exploration of many activities, providing new ways of thinking and act. Thus, the current study investigated as a didactic sequence, using learning objects (LO), could help in the understanding of concepts related to information processing as the construction and interpretation of bar and sectors graphs. The work was conducted in a Brazilian public school located in Fortaleza city using two classes of 5th grade of elementary school, with 26 students each ones. The school classes were divided in control group (CG) and experimental group (EG) and all students were previously evaluated through a pre-test. Posteriorly an intervention using a didactic sequence including mathematical aspects of graphs and tables, problem situations with classification and proportionality and research activities was performed only with EG. The GC was not exposed to any formal education beyond the classroom received. Thereafter a post test was applied to both groups (CG and EG). The data were analyzed by student performance before and after the performed activities taking into account the evolution of strategies and information processing. Was observed a improviment in the strategies used by children for GE group after intervention. These activities give the integration of different technologies employed in school curriculum (laptop and digital and analogic technologies). Thus, the use of digital technologies provided didatic experiences in processing information by students as a to visualize and simulate different situations; process information; work with real situations, with investigative contexts and explore the produced data. Therefore, the results of current study contribute to better understand the graphs learning as well as for further development of new resources and activities.

Introducción: El pie diabético se asocia a una alta morbimortalidad siendo la principal causa de amputación no traumática de miembros inferiores. Las amputaciones conllevan a discapacidad, mortalidad prematura y una reducción en calidad de vida en los pacientes diabéticos. Objetivo: Identificar los factores de riesgo para la amputación de pacientes adultos con pie diabético en la primera hospitalización con úlcera pedia en el servicio de endocrinología del Hospital Nacional Edgardo Rebagliati durante el periodo 2009 al 2017. Material y Métodos: Se realizó un estudio retrospectivo, observacional, analítico tipo cohorte. Nuestra variable dependiente fue amputación la cual estuvo definida como la amputación primaria registrada en la historia clínica posterior a la primera hospitalización debido a úlcera pedia. Mediante la revisión de historias clínicas, se recopilaron datos sobre factores sociodemográficos, relacionados a diabetes mellitus 2 y valores de laboratorio durante la primera hospitalización por úlcera pedia. Se llevó a cabo un modelo de regresión crudo y ajustado de la familia Poisson con varianza robusta. Se presentó como medida de asociación al riesgo relativo (RR) con su respectivo intervalo de confianza al 95%. Aquellas variables con un p<0,05 en análisis crudo ingresaron al análisis ajustado. Resultados: En total analizamos 163 pacientes con úlcera pedia en su primera hospitalización, el 55.21% fue mayor a 60 años y 70.55% fueron varones. Los amputados fueron 63 participantes. En el análisis ajustado, las variables asociadas a un mayor riesgo de amputación fueron enfermedad arterial periférica (RR=1.57; IC95%: 1.09 - 2.25, p=0.01), Wagner grado IV (RR=4.25; IC 95%: 1.41 - 12.77, p=0.01) y glucosa de admisión>130 mg/dl (RR=2.40; IC 95%: 1.10 - 5.24, p= 0.02). Conclusión: Se reconocen como factores de riesgo para la amputación la enfermedad arterial periférica, el estadio avanzado de la úlcera y los niveles elevados de glucosa. / Backgroud: Diabetic foot may cause significant morbidity and is the main cause of nontraumatic lower extremity amputation. Amputations involves a complex underlying including disability, premature mortality and a reduction in the quality of life.  Objective: To identify the risk factors associated with the amputation of adult patients with diabetic foot in their first hospitalization with diabetic foot ulcer in the endocrinology service of the National Hospital Edgardo Rebagliati during the period 2009 to 2017. Methods: We performed a retrospective, observational, analytical cohort study. Our outcome was amputation which was defined as the primary amputation recorded in the clinical history during hospitalization. Through the review of medical records, data were collected on sociodemographic factors, related to diabetes mellitus 2, related to diabetic foot ulcer and emergency laboratory values. We carried out a crude and adjusted regression model of the Poisson family with robust variance. It was presented as a measure of association to the relative risk (RR) with 95% confidence interval. Variables presenting p < 0.05 in the crude analysis were selected to enter the adjusted model. Results: In total, 163 patients were diagnosed with diabetic foot ulcer in their first hospitalization, 55.21% were older than 60 years and 70.55% were male. The amputees were 63 participants. The results of the adjusted model showed that peripheral arterial disease (RR=1.57; IC95%: 1.09 - 2.25, p=0.01), Wagner grade IV (RR=4.25; IC 95%: 1.41 - 12.77, p=0.01) and admission plasma glucose>130 mg/dl (RR=2.40; IC 95%: 1.10 - 5.24, p= 0.02) were associated with amputation. Conclusions: The peripheral arterial disease, the advanced stage of the ulcer and high levels of admission plasma glucose are recognized as risk factors for amputation. / Tesis

Introducción La úlcera de pie diabético (UPD) es una complicación clínica de la diabetes mellitus (DM). Se ha sugerido que la anemia podría asociarse a su progresión. El objetivo de nuestro estudio fue evaluar la asociación entre anemia y los desenlaces clínicos adversos de la UPD en pacientes hospitalizados. Métodos Llevamos a cabo un análisis secundario de base de datos de dos estudios de cohorte retrospectivo de pacientes con UPD hospitalizados en un hospital público de referencia nacional en Lima durante el año 2015 y 2019. La anemia definida según el valor de hemoglobina de ingreso fue nuestra variable de exposición. Para nuestra variable resultado, agrupamos la falla en la cicatrización y la amputación, en la variable “desenlace clínico adverso”. Estimamos riesgos relativos crudos (RR) y ajustados (RRa) con intervalos de confianza al 95% (IC95%) mediante modelos lineales generalizados de familia Poisson con Bootstrap no paramétrico con sesgo corregido y acelerado. Resultados Incluimos 160 pacientes cuya media de edad fue 58 ± 12,7 años. Detectamos anemia en 102 (63,8%) pacientes, 111 (69,4%) presentaron el desenlace clínico adverso, 49 (44,1%) fueron amputados, y 62 (55,9%) pacientes presentaron una úlcera que no cicatrizó. La anemia se asoció significativamente con el desenlace compuesto (RRa = 1,37: IC95% = 1,05 - 1,80; p=0,019) y la amputación (RRa = 1,78: IC95% = 1,12 - 3,28; p=0,017). No encontramos evidencia estadística de asociación significativa entre la anemia y la falla en la cicatrización de la UPD (RRa = 1,43: IC95% = 0,96 - 2,12; p=0,072). Conclusión La anemia incrementó el riesgo de presentar un desenlace clínico adverso y de la amputación en pacientes hospitalizados con UPD. / Background Diabetic foot ulcer (DFU) is a clinical complication of diabetes mellitus (DM). Anemia has been associated with the progression of this disease. The objective of our study was to evaluate the association between anemia and adverse clinical outcomes of DFU in hospitalized patients. Methods We carried out a secondary database analysis from two retrospective cohort studies of DFU patients hospitalized in a national reference public hospital in Lima during 2015 and 2019. The exposure variable was anemia defined according to the hemoglobin value at admission. For our outcome variable, we grouped non-healing ulcers and amputation into the “adverse clinical outcome”. We estimated crude (RR) and adjusted relative risks (aRR) with 95% confidence intervals (CI95%) using generalized linear Poisson family models with accelerated and bias-corrected non-parametric bootstrap. Results We included 160 patients, which average age was 58 ± 12.7 years. Anemia was detected in 102 (63.8%) patients, 111 patients (69.4%) had an adverse clinical outcome, 49 patients (44.1%) were amputated, and 62 patients (55.9%) had non-healing ulcers. Anemia was significantly associated with the composite outcome (aRR = 1,37: CI95% = 1,05 - 1,80; p=0,019) and amputation (aRR = 1,78: CI95% = 1,12 - 3,28; p=0,017). We found no statistical evidence of a significant association between anemia and non-healing ulcers (aRR = 1,43: CI95% = 0,96 - 2,12; p=0,072). Conclusions Anemia increases the risk of amputation and adverse clinical outcome in hospitalized patients with DFU. / Tesis

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No description available.

Las complicaciones del pie diabético son costosas y en gran parte prevenibles a través del autocuidado. Por ello, esta investigación tuvo por objetivo: comprender el autocuidado de los pies en personas con diabetes mellitus tipo 2 atendidas en un hospital público de Chiclayo¿'2023. Esta investigación fue de tipo cualitativa, con un diseño descriptivo. Los sujetos que participaron fueron personas con diabetes mellitus tipo 2 que se atendían en el hospital Las Mercedes y se excluyeron a los que tenían pie diabético o amputación. La muestra fue no probabilística, por conveniencia. El tamaño de la muestra fue delimitado por saturación y redundancia. Para la recolección de datos se utilizó una guía de entrevista semiestructurada, validada por juicios de expertos y prueba piloto. Luego fue aprobada por el Comité de Ética en Investigación de la Facultad de Medicina para la ejecución del proyecto. Se procesaron los datos mediante análisis de contenido temático; así mismo, se aplicaron los criterios de rigor científico y principios éticos de bioética de Sgreccia. Los resultados fueron representados por 5 categorías: a) Hábitos en la revisión, higiene, secado y humectación de los pies, b) Apoyo familiar en el recorte de uñas y las medidas para mejorar la circulación de los pies, c) Uso del calzado adecuado dentro y fuera del hogar según temporada climática y comodidad, d) Costumbres y uso de la medicina tradicional en el autocuidado de los pies, e) Autoaprendizaje y necesidad de educación sanitaria para el autocuidado de los pies. En este estudio, los pacientes diabéticos muestran deficiencias en su autocuidado, como falta de hidratación en los pies. A pesar de algunas prácticas positivas, como la higiene adecuada de pies; la falta de apoyo familiar y la limitada enseñanza del personal de salud contribuyen a prácticas riesgosas. Se destaca la necesidad de proporcionar educación y supervisión para prevenir complicaciones. / Diabetic foot complications are costly and largely preventable through self-care. Therefore, this research aimed to: understand foot self-care in people with type 2 diabetes mellitus treated at a public hospital in Chiclayo, 2023. This research was qualitative, with a descriptive design. The subjects who participated were people with type 2 diabetes mellitus who were treated at the Las Mercedes hospital and those who had diabetic foot or amputation were excluded. The sample was non-probabilistic, for convenience. The sample size was limited by saturation and redundancy. A semi-structured interview guide was used to collect data, validated by expert judgments and pilot testing. It was then approved by the Research Ethics Committee of the Faculty of Medicine for the execution of the project. The data were processed through thematic content analysis; Likewise, the criteria of scientific rigor and ethical principles of Sgreccia bioethics were applied. The results were represented by 5 categories: a) Habits in checking, hygiene, drying and moisturizing the feet, b) Family supportin trimming nails and measures to improve foot circulation, c) Use of appropriate footwear inside and outside the home depending on the weather season and comfort, d) Customs and use of traditional medicine in foot self-care, e) Self-learning and the need for health education for foot self-care. In this study, diabetic patients show deficiencies in their self-care, such as lack of hydration in their feet. Despite some positive practices, such as proper foot hygiene; The lack of family support and the limited teaching of health personnel contribute to risky practices. The need to provide education and supervision to prevent complications is highlighted.

[pt] O tema do testemunho cristão é o foco principal deste trabalho. Segundo Salvador Pié-Ninot, na sua Teologia Fundamental, o testemunho se apresenta como a nova via empírica, isto é, o novo caminho que, através da vida cotidiana da Igreja com suas experiências diversas, por vezes até paradoxais, se apresenta como motivo coerente e plausível para se crer. Afinal, o testemunho é como que uma condição primeira necessária à credibilidade da fé. Isso é importante na tarefa apologético-dialogal da Teologia Fundamental. Dentro desta, na parte da Eclesiologia Fundamental, o testemunho é tido como elemento-chave de credibilidade na Igreja e passa a ser conhecido como via testimonii, por ser o caminho mais enfático, notório e coerente para a evangelização. A perspectiva do testemunho que, segundo Pié-Ninot é sempre teológico, dá-se no testemunho eclesial como mistério envolto em paradoxo. O testemunho cristão conduz à tarefa apologética, facilitando o diálogo na Igreja, quer pessoal (pela oração a Deus e Liturgia), quer com os irmãos (diálogo ecumênico e inter-religioso); e na diaconia do serviço de amor ao próximo. / [en] The theme of Christian testimony is the main focus of this work. According to Salvador Pié-Ninot on his Fundamental Theology, testimony is presented as the new empirical way. It means a new way in which the daily life of the Church with its various experiences, sometimes even paradoxical ones, presents itself as a coherent and plausible reason to believe. After all, testimony is a first condition required to the credibility of the faith. It is important in the apologetic-dialogical task of Fundamental Theology. Within this, in the part of Fundamental Ecclesiology, testimony is considered as a key element of Church s credibility. It is known as via testimonii, because it is the most emphatic, notorious and coherent way for evangelization. In the perspective of testimony, according to Pié-Ninot, testimony is always theological; it is an ecclesial testimony like a mystery wrapped in paradox. Thus, Christian s testimony drives us to an apologetic task, making Church s dialogue easy. It can be personal dialogue (through prayer to God and in the Liturgy) or with the brothers (in an Ecumenical Dialogue or an Interreligious one). It can also be in a perspective of diakonia in the service of love to our brothers.

Mgr Dupanloup est l’une des figures de proue du catholicisme libéral en France au XIXe siècle. À partir de la correspondance privée du prêtre de Savoie, il s’agit de mettre en exergue les réseaux mis en place et structurés par le prêtre de Savoie pour défendre les intérêts de l’Église catholique dans un contexte de tensions révolutionnaires. Ainsi sous la Seconde République, de 1848 à 1851, Dupanloup et ses réseaux se concentrent particulièrement sur la lutte pour la liberté de l’enseignement et à partir de 1849 sur la lutte pour le vote du projet de loi Falloux, un projet de loi visant à réorganiser entièrement l’instruction publique et privée. Autour de Dupanloup s’agrège tout un ensemble de partis, de réseaux et de personnalités d’origines diverses, laïcs et ecclésiastiques, religieux et politiques qu’on a pu réunir sous l’appellation de « parti Dupanloup ». Ce « parti » repose avant tout sur le « duo » Dupanloup-Montalembert, devenu « trio » dès lors qu’Alfred de Falloux est devenu ministre avec comme objectif prioritaire d’obtenir la liberté de l’enseignement secondaire et de soutenir l’autorité temporelle du pape. Des stratégies apparaissent dans la correspondance et les écrits privés de Dupanloup qui constituent les coulisses de l’action publique du prêtre pédagogue. Ces échanges épistolaires forment un maillage resserré entre des individus partageant plus ou moins les mêmes convictions et objectifs et visant à incliner le processus révolutionnaire en leur faveur. C’est dans l’espace privé de la correspondance que Dupanloup construit déjà son action publique. Étudier les réseaux et le combats du parti de Dupanloup sous la Seconde République permet de revenir plus précisément sur un pan de l’histoire assez méconnu. Les conflits qui agitent la vie politique, sociale et religieuse de la Seconde République sont, en effet, révélateurs du bouillonnement idéologique, politique, social et religieux du milieu du XIXe siècle. Il cristallise des débats publics qui animent encore l’Europe du XXIe siècle, notamment sur la question de la laïcité ou de la sécularisation de la société. L’évolution de la pensée de Dupanloup durant cette période révèle les tensions et dissensions qui agitent les catholiques libéraux dans leur rapport entre eux-mêmes, mais aussi dans leur relation avec le clergé et avec la société.Il semble ainsi pertinent de comprendre comment un groupe de catholiques conservateurs, lui-même en minorité au sein du mouvement catholique libéral, est parvenu à se hisser au sommet d’institutions républicaines alors que de 1848 à 1851 les journées révolutionnaires se multiplient et se radicalisent. Peut-on conclure à une victoire du « parti Dupanloup » ? La Révolution sociale avortée dès juin 1848 s’est-elle mue en Contre-Révolution ou bien paradoxalement en Révolution catholique ? / Bishop Dupanloup was one of the leading figures of the liberal Catholicism in France in the 19th century. From the private correspondence of the priest of Savoy, the objective is to highlight the networks which were set up and structured by the priest of Savoy to defend the interests of the Catholic Church in a context of revolutionary tensions.Under the Second Republic, from 1848 to 1851, Dupanloup and his networks particularly focused on the struggle for freedom of education and from 1849 on the struggle for the vote of the Falloux bill, a bill aimed to completely reorganize public and private education. Around Dupanloup an ensemble aggregated, made of parties, networks and personalities of various origins, lay and ecclesiastical, religious and political, who were known as the "Dupanloup party". This "party" relied above all on the "duo" Dupanloup-Montalembert, who turned into a "trio" when Alfred de Falloux became minister of public education and worship with the primary objective of obtaining the freedom for the Secondary education and to support the temporal authority of the pope. Strategies appear in the correspondence and private writings of Dupanloup that form the backdrop of the public action of the pedagogical priest. These epistolary exchanges form a tight grid between individuals sharing more or less the same convictions and objectives and aiming to tilt the revolutionary process in their favor. It is in the private space of correspondence that Dupanloup already built his public action. Studying the networks and the battles of the party of Dupanloup under the Second Republic makes it possible to go back more precisely to a part of history which is quite unknown. The conflicts which agitated the political, social and religious life of the Second Republic were indeed revealing of the ideological, political, social and religious bubbling turmoil of the mid-nineteenth century. It crystallized public debates that still animated the Europe of the 21st century, notably on the question of secularism or the secularization of society. The evolution of Dupanloup's thinking during this period reveals the tensions and dissensions which agitated liberal Catholics themselves but also their relationship with the clergy and with society.It seems relevant to understand how a group of conservative Catholics, a minority itself within the liberal Catholic movement, managed to rise to the top of republican institutions, whereas from 1848 to 1851 revolutionary days multiplied and radicalized. Can we conclude with a victory of the "Dupanloup party"? Was the Social Revolution which aborted in June 1848 a Counter-Revolution or paradoxically a Catholic Revolution ?