Sua história natural e o real risco à função renal foram pouco estudados. Objetivo: Avaliar o impacto do cálculo ureteral silencioso sobre a função renal antes a após o tratamento, procurando por fatores preditivos de uma melhor evolução. Material e Método: O cálculo ureteral silencioso foi definido como aquele em que o paciente não apresentava nenhum sintoma subjetivo ou objetivo a ele relacionado. Os pacientes com cálculo ureteral silencioso foram prospectivamente incluídos no estudo, sendo avaliados com 99mTc-DMSA, creatinina sérica (Cr), ritmo de filtração glomerular (RFG) e ultrassonografia (USG) no pré-tratamento, três e 12 meses após o mesmo. Pacientes que receberam tratamento fora de nossa instituição e aqueles com avaliação perioperatória incompleta foram excluídos. A análise estatística incluiu os testes de ANOVA, Qui-quadrado/Fisher, e regressão logística/múltipla. O nível de significância foi estabelecido em p<0,05. Resultados: Entre jan/2006 e jan/2014, 26 pacientes com cálculo ureteral silencioso, correspondendo a 2,1% de todos os cálculos ureterais tratados, preencheram os critérios de inclusão do estudo. Treze pacientes eram do sexo feminino, com idade média de 59,3 ± 11,3 anos. O diagnóstico do cálculo foi relacionado a uma causa urológica em 14 (53,8%) casos. O diâmetro e densidade média dos cálculos era de 11,8 ± 2,8 mm e 1201 ± 272 UH, respectivamente. Apenas dois pacientes não apresentavam hidronefrose ao USG inicial e a espessura média do parênquima renal era 10,7 ± 4,1 mm. Os valores médios pré-operatórios de Cr, RFG e 99mTc-DMSA foram 1,24 ± 0.87 mg/dl, 72,5 ± 25.2 mL/min e 33,4 ± 16,7%, respectivamente. Vinte (77%) pacientes apresentavam 99mTc-DMSA < 45% no exame inicial. Regressão múltipla revelou que idade (p=0,041) e espessura do parênquima renal (p=0,001) predizem o valor do 99mTc-DMSA inicial. Quando comparados com os valores pré-operatórios, a Cr (p=0,89), o RFG (p=0,48) e a função renal ao 99mTc-DMSA (p=0,19) permaneceram inalterados com três e 12 meses após o tratamento. A hidronefrose apresentou melhora três meses após o tratamento (p < 0,01), mas manteve-se inalterada no período entre três e 12 meses (p=0,06). Nenhuma variável pré-operatória foi capaz de prever uma variação > 5% do 99mTc-DMSA entre pré e pós-operatório, sendo que o tamanho do cálculo (p=0,12) e tempo para tratamento (p=0,15) tiveram influência marginal. Conclusão: O cálculo ureteral silencioso está associado à diminuição da função renal e algum grau de hidronefrose já ao diagnóstico. Idade, espessura do parênquima renal e grau de hidronefrose predizem o valor inicial do 99mTc-DMSA. Enquanto a hidronefrose regride após a remoção do calculo, a função renal se mantém inalterada. Nenhum fator conseguiu predizer significativamente a evolução da função renal ao 99mTc-DMSA doze meses após o tratamento / Introduction: Ureteral stones may be asymptomatic in 0.3-5.3% of patients. The natural history and the disease influence on renal function have been poorly studied. Objective: to evaluate the impact of silent ureteral stone on renal function before and after treatment, searching for predictive factor of better outcomes. Material and Method: A ureteral stone was defined as silent if the patient had no subjective/objective symptoms related to the calculus. Patients with a silent ureteral stone were prospectively enrolled in the study. Patients were evaluated with 99mTc-DMSA scintigraphy, serum creatinine (Cr), Cr clearance (CrCl) and ultrasound (USG) pre and post-operatively on months three and 12. Patients treated outside our institution or with incomplete perioperative evaluation were excluded. ANOVA, Chi-square/Fisher test, and regression analysis were used. Significance was set at p < 0.05. Results: Between Jan/06-Jan/14, 26 patients with silent ureteral stones met our inclusion criteria, comprising 2.1% of all ureteral stones treated at our institution. Half of patients were female, mean age was 59.3 ± 11.3 years-old. Stone diagnosis was related to a urological cause in 14 (53.8%) cases. Mean stone diameter and density were 11.8 ± 2.8 mm and 1201 ± 272 HU, respectively. Only two patients had no hydronephrosis at initial USG evaluation and mean renal parenchyma thickness was 10.7 ± 4.1mm. Mean preoperative Cr, CrCl and 99mTc-DMSA were 1.24 ± 0.87 mg/dL, 72.5 ± 25.2 mL/min and 33.4 ± 16.7%, respectively. Twenty (77%) patients had 99mTc-DMSA < 45% at initial examination. Multiple regression revealed age (p=0.041) and renal parenchyma thickness (p=0.001) to predict initial 99mTc-DMSA. When compared to preoperative values, Cr (p=0.89), CrCl (p=0.48) and 99mTc-DMSA (p=0.19) remained unaltered three and 12 months postoperatively. Hydronephrosis improved from before to three months after treatment (p < 0.01), but remained unchanged from three to 12 months (p=0.06). No preoperative variable was able to predict a > 5% variation on 99mTc-DMSA from pre to postoperative periods, though stone size (p=0.12) and time to treatment (p=0.15) had a marginal influence. Conclusion: Silent ureteral stones are associated with decreased renal function and hydronephrosis already at diagnosis. Age, renal parenchyma thickness and degree of hydronephrosis predict initial 99mTc-DMSA. Hydronephrosis tends to diminish after stone removal, while renal function remains stable. No preoperative factor significantly predicted renal function progression twelve months postoperatively

Célèbres et reconnus mais peu discutés, les films réalisés par Erich von Stroheim, entre 1919 et 1929 à Hollywood, occupent une place problématique dans l’histoire et la théorie du cinéma. Les discours contradictoires ou paradoxaux qu’ils ont inspirés animent cette recherche. Œuvre à la fois mutilée, reconstruite ou ruinée, elle est indissociable d’une expérience du temps. La versatilité des mondes et les métamorphoses de l’intrigue qu’elle propose, malgré un régime narratif évident, invitent à reconsidérer les catégories de l’histoire du cinéma muet américain. Interrogeant la représentation de l’histoire, ces films donnent à penser l’événement de la Première Guerre mondiale comme un point aveugle, et livrent une historicité composite. Au sein des pratiques du cinéma muet hollywoodien, les films de Stroheim se distinguent par l’invention d’un montage en accolade produisant une continuité qui incite à envisager la question de la durée. Ces films s’écartent de ce qu’à la même époque instaure le naturalisme américain par-delà les modèles littéraires. Pour analyser ce cinéma dans sa complexité, sera examiné l’être stroheimien selon les devenirs qui le font changer dans la durée, différemment de son appréhension dans le temps chronologique. De sorte que leurs devenirs se mesurent relativement aux êtres cédant à l’entropie ou au contraire demeurant des invariants. Selon cette configuration générale, Stroheim crée les conditions d’une expérimentation distincte de celle du naturalisme traditionnel. / The films directed by Erich von Stroheim in Hollywood between 1919 and 1929, though little discussed, are famous and renowned, but they still remain an issue in both film history and film theory. Contradictions and paradoxes that characterize the discourses on these films drive this research. The works of Erich von Stroheim were in turns butchered, reconstructed, destroyed. Our aim is to show that it entails strongly an experience of time. Despite their obvious narrative plots, these films suggest a changeability of worlds and a metamorphosis of plot that lead us to review the standard approaches of American silent film history. While they question the representation of history, these films make the event of World War I appear as a blind spot, and reveal heterogeneous modes of historicity. Within the experiences of Hollywood silent films, the works of Erich von Stroheim are characterized by the creation of a bracket montage (montage en accolade), producing a continuity that invites us to consider the issue of duration. Beyond literary models, these films differ from what is established by American naturalism at the time. In order to make way for their complexity, we will study the Stroheim-being according to what it becomes and changes itself in duration, which is not what we could understand of it in chronological time. So what becomes of it is estimated with regard to its yielding to entropy, or, on the contrary, its remaining invariably the same. In accordance with this general configuration, Stroheim creates conditions that experiments a new way for naturalism.

La recherche interroge la valorisation des archives du Nederlands Filmmuseum [NFM] à partir du travail de compilation du cinéaste Peter Delpeut. Ce corpus de dix films [1989-1999] se situe à cheval entre deux ambitions qui ne sont pas toujours compatibles, entre une volonté d’archiviste de rendre accessible des films muets [1895-1931] parfois de simples fragments, en restituant leur couleur, en créant une sonorisation et une quête artistique, plus personnel et liée à un cinéaste. Convoquant des sources audiovisuelles mais également écrites et orales, il s’agit d’abord de se demander comment le NFM en vient à produire ces compilations afin de mettre en valeur ses collections, de tracer l’histoire de cette cinémathèque et de suivre la trajectoire de Delpeut, en somme de comprendre la rencontre entre cet homme riche d’une expérience de recherche, de critique et de réalisation et une institution en plein bouleversement de sa philosophie dans les années 1990. Le questionnement s’oriente ensuite sur le processus de fabrication lui-même et de la façon dont fonctionnent ces compilations en vue de montrer comment elles sont prises en tension entre le sensoriel et l’analytique, étant au-delà et en deçà d’une stricte valorisation des films muets du NFM. La dernière partie interroge les usages des compilations, la manière dont elles sont liées à la politique de programmation du NFM, comment elles affectent la dynamique de l’institution et du cinéaste, mais aussi comment elles sortent du cadre de la cinémathèque, évaluant à chaque fois les apports et les limites en terme de transmission d’un patrimoine cinématographique. / The research examines the promotion of film archives from the Netherlands Filmmuseum [NFM] through Peter Delpeut’s compilation work. These ten films [1989-1999] are between two directions that are not always in compatibility, on one side an artistic cinematic search and on the other side the archivist’s will of giving access to silent films [1895-1931] that are in fragments, in colour and with a sound creation. Using audiovisual, written and oral sources, the first interest is to focus on whether how the NFM comes to produce these compilations for promoting its collections, lining out the history of this film archive and following Delpeut’s career, to understand the meeting between a man with great experience as researcher, critic and filmmaker and an institution challenging its philosophy during the 1990’s. The research then examines the process of filmmaking itself and functioning of this compilation work to show that there is a tension between sensorial and analytical terms, over the borderline of a strict promotion of NFM’s silent films. The last part explores the utilisation of these compilations, the way they are related to Museum’s programming politics, how they affect this institution and Delpeut’s dynamics, beyond the film archive, each time evaluating the contributions and limitations for the transmission of silent cinema heritage

This diploma thesis follows up on the bachelor thesis which dealt with the phenomenon of silent letters and which was created by the same author. This bachelor thesis has revealed that Czech learners tend to mispronounce every fifth word containing a silent letter which should be seen as alarming. The diploma thesis therefore tries to find some way how to change this situation. The theoretical part of this thesis focuses on the analysis of various techniques and materials which are concerned with silent letters. In the practical part this materials are adjusted to the needs of the Czech learners in order to create a battery of activities which would cover this area of pronunciation. In the next step these activities will be introduced in English classrooms. In the research we will monitor the progress of the respondents over a larger period of time and assess how effective the created activities are.

Southern right whale vocalisations recorded in Walker Bay, South Africa, between June and November 1999, were analysed to investigate the acoustic repertoire, the relationship between calling behaviour and whale presence, the proportions of vocal and silent whales, and of recorded calls from unseen whales, and the evidence for vocal individuality. This marks the first study of right whale vocalisation in South African waters. A simple matrix system with the axes acoustic contour and onset frequency described twelve call types. Analysis of call use over time indicated that some calls, as well as broadband gunshots, clustered strongly in bouts of differing lengths, and that their relative use varied over the season; the repertoire and its classification was compared with other accounts of right whale vocalisation [chapter one]. A generalised linear model explained the variation in the overall call rate in terms of the numbers of whales present, month and wind direction. The overall call rate, for each month and in all wind conditions, rose with increasing whale numbers to a plateau at between ten and fifteen whales, and then declined as whale numbers rose further, suggesting that the social motivation for vocalising was progressively reversed. An inverse linear relationship between call rate per whale and whale abundance was clearly demonstrated over the whole season, indicating that call rates were unreliable as an indicator of whale numbers [chapter two]. A dual-axis, three-element hydrophone array suspended at 5m from floating buoys was designed to assign whale vocalisations to calling whales. The array was calibrated with an overall mean error of 3°. Bearings to calling whales were calculated using correlelograms, and compared with the observed positions of whales. On average 31% of low up (upwardly inflected) calls and 11% of medium and high down (downwardly inflected) calls came from whales not sighted from the boat; up to just under half of the whales sighted from the boat were silent. This indicates the importance of integrating visual and acoustic data when estimating whale numbers [chapter three]. In characterising individuality in vocalisations, we used cluster analysis of acoustic properties of whale calls to derive the Euclidean distances (a measure of similarity) between each possible pair of calls within a continuous recording session. Calls clearly from different whales (distant call pairs) were more dissimilar than calls possibly from one whale (‘close’ call pairs), lending support to the hypothesis of vocal individuality. The similarity between ‘close’ up calls was greatest when the calls were within 0.5 minutes of each other, and declined progressively, up to a separation of 6.5 minutes, as the likelihood of both calls being from one whale declined, indicating individual bout-calling. Medium and high down (downwardly inflected) calls, associated with surface active groups (SAGs), and thought by other researchers to be produced by the focal female, were more similar within any given SAG than when compared across SAGs. This evidence strongly suggests that southern right whales produce individually distinctive vocalisations [chapter four]. / Thesis (PhD)--University of Pretoria, 2010. / Zoology and Entomology / unrestricted

In Saccharomyces cerevisiae, telomeric and HM silencing requires the histone deacetylase Sir2 and the chromatin binding proteins Sir3 and Sir4, which interact to form the SIR complex. Silent chromatin formation begins with a nucleation step, followed by spreading of Sir proteins along chromatin. Overexpression of Sir3 extends silent chromatin domains, however the role of Sir protein interactions within silent chromatin extensions remains unknown. Here, we generated the Sir3 mutant, Sir3-4A, which cannot interact with Sir4 but is capable of forming silent chromatin extensions when overexpressed. Within extended silent domains, Sir2 and Sir4 enrichments are similar whether Sir3 or Sir3-4A is overexpressed, suggesting that silent chromatin extensions require Sir4 but not the interaction between Sir3 and Sir4. Tethering Sir3-4A at an HMR silencer cannot nucleate silencing in the absence of Sir3, suggesting that in addition to Sir3 recruitment, the Sir3-Sir4 interaction has at least one other function during silent chromatin nucleation.

Det här arbetet syftar till att få en tydligare bild på om lärare arbetar med tyst läsning i sina klasser och hur dessa lärare i sådana fall arbetar med det i sina klasser. Undersökningen grundar sig i fyra frågor vilka är: Hur arbetar lärare med tyst läsning? Vad bidrar tyst läsning med för svenskämnet enligt lärarna?Vad för sorts litteratur får eleverna tillgång till att läsa? Skönlitteratur/ fakta m.m.?Vad anser lärare att målet med tyst läsning är för deras elever? Dessa frågor är alla skrivna med utgångspunkt i att verksamma lärare ska kunna svara på dem. Detta gjordes för att studiens huvudsakligen grundar sig i en enkät. Alla de svar som har samlats in analyseras och ses genom ett sociokulturellt perspektiv. Enkäten och den presenterade forskningen visar att lärare arbetar på det sättet som forskningen säger att lärare bör arbeta med tyst läsning, genom att ha det som komplement till den annan läsundervisning. / This work aims at getting a clearer picture of teachers’ work with silent reading in their classes. Do they use silent reading and how in that case are they working with it in their classes? This is based on four questions which are: How do teachers work with silent reading?What does silent reading contribute to the Swedish subject according to the teachers?What kind of literature do students have access to reading? Fiction/non-fiction, etc.? What do teachers think the aim of silent reading is for their students? These questions are all based on the assumption that if given to an active teacher, she should be able to answer them. This was done because the study mainly is based on a questionnaire. All the answers collected are analyzed and viewed through a sociocultural perspective. The questionnaire show that teachers work in the same way as the research say they should with silent reading, which is like a complement to the other reading lectures.

The main aim of this diploma thesis is to evaluate and select the most appropriate option how to mount a power unit in Formula Student vehicle. It assesses an overall dynamic behaviour of a drive unit mounted in student formula. At the end of the final thesis is an assessment of proposed engine mount variants. The study of parameters that most influence engine vibrations can be seen there.

The purpose of this study was to examine social workers’ experiences of communication with silent children, what conservation methods, tools and aids may be used and how the child’s participation thereby can be stimulated. The study was based on two research questions which were following: What affects the child’s silence in conversation along with what conversation methods, aids and what tools can be used in order to engage and include the child? The following study consisted of a qualitative nature and five interviews were conducted with social workers working in different fields. In addition to the interviews, research was sought in order to receive insight into the research area. The search process was not limited to the nation's borders, but consisted of global research. As a result of this, a huge lack of useful research was discovered. The results showed that factors such as social workers’ personal qualities, the character of the methods used and communicative skills had a considerable effect on the child’s motivation and will to participate. Although silent children are common in the conversation room and exist in each area of the social work’s practice, there is no comprehensive research or direct guidelines to mastering such meetings.

Författare, forskare och lärare har länge lyft fram skönlitteraturs förmåga att låta läsare förstå sina egna liv och erfara andras till en grad utan motsvarighet bland pedagogiska och didaktiska redskap. Vad gäller verk som simultant kan imponera med litterär kvalité och värdegrundsfrämjande potential kan få konkurrera med Oima Yoshitokis manga Koe no katachi (sv. (En) Tyst Röst), ett påstående som denna uppsats syftar att bevisa. Genom att analysera mangan i förhållande till skolans vädegrund, gymnasiesvenskämnets kunskapskrav, samt forskning om didaktisk potential, litterär kompetens, mobbningsbekämpning och diskriminering framhäver denna studie hur väl mangan lämpar sig i gymnasiesvenskarbete. Resultaten visar att Koe no katachi kan utmana elever på sätt likvärdiga med mer konventionell litteratur (epik, lyrik och dramatik), att den har god didaktisk potential, och att den överensstämmer väl med forskares tankar om verk som utvecklar elevers litterära kompetens. Mangan ger god inblick i mobbning och diskriminring som fenomen (med specifikt fokus på diskriminering utifrån funktionsvariation, kön och könsöverskridande identiteter och uttryck), och innehåller viktiga budskap om medmänsklighet och förståelse. Slutsatsen är således att mangan skulle fungera utmärkt både för gängse skönlitteraturundervisning och värdegrundsfrämjande klassrumsarbeten, men att mangas fallande status och svåråtkomlighet i Sverige likväl gör gymnasieanvändning av den opraktisk i dagsläget.