pós-infarto agudo do miocárdio (IAM) têm mostrado baixo valor preditivo positivo quando estudados isoladamente. A possibilidade da Eletrocardiografia Dinâmica de 24 horas (ECGD) fornecer dados referentes a isquemia silenciosa (IS), arritmias ventriculares e modulação autonômica do coração pelo estudo da variabilidade da freqüência cardíaca (VFC), levou o autor a empregar este método em pacientes acometidos de IAM com o objetivo de avaliar se estas três variáveis estariam relacionadas a presença de eventos desfavoráveis em evolução a médio prazo. Material e Métodos – Foram selecionados 91 pacientes acometidos de um primeiro IAM não-complicado e realizados exames de ECGD de 24 h por dois dias consecutivos, antes da alta hospitalar. Os parâmetros pesquisados nos exames foram: isquemia silenciosa, identificação e quantificação de arritmias ventriculares e determinação dos índices de VFC pelos métodos do domínio do tempo e do mapa de retorno tridimensional. Foram considerados como desfechos: re-infarto, angina instável, taquicardia ventricular sustentada e morte. Resultados – No seguimento médio de 27,7 meses (DP=15,45), 23 (25%) dos pacientes apresentaram eventos, sendo nove fatais. Os eventos foram mais freqüentes entre os pacientes que apresentaram extra-sístoles ventriculares ≥10/hora (p=0,01) e também naqueles com IS (p=0,02). Em modelo de análise multifatorial, a presença de dislipidemia elevou o valor preditivo positivo dessas variáveis. Nenhum dos índices de VFC esteve significativamente relacionado ao surgimento de eventos. Conclusões – Em pacientes pós-IAM de baixo risco, a presença de arritmias ventriculares freqüentes ou de isquemia silenciosa está relacionada a um prognóstico desfavorável. O estudo da VFC não mostrou utilidade na estratificação de risco destes pacientes. / Introduction and objective – The noninvasive methods used in post-acute myocardial infarction (AMI) risk stratification have been shown to have a low predictive value when studied in isolation. The possibility that ambulatory electrocardiographic monitoring (AEM) may provide data on silent ischemia (SI), ventricular arrhythmias (VA) and autonomic modulation of the heart through the study of heart rate variability (HRV) led the present author to use this method in AMI patients with the aim of assessing whether these three variables could be related to the presence of unfavorable events in the medium term follow-up. Methods – Ninety-one patients with a first, uncomplicated AMI were selected and submitted to AEM for two consecutive days prior to discharge from the hospital. The parameters studied in the examination were as follows: presence of SI, identification and quantification of VA and determination of the HRV indices by the time domain and three-dimensional return map methods. The following were regarded as outcomes: new AMI, unstable angina, sustained ventricular tachycardia and death. Results – In the mean follow-up of 27.7 months (SD=15.45), 23 (25%) of the patients presented events, nine of which were fatal. Events occurred most frequently in the patients who presented ventricular premature contractions >= (p=0.01) and also in those with SI (p=0.04). In the multifactorial analysis the presence of dislipidemia raised the positive predictive value of these variables. None of the HRV indices was significantly correlated with the occurrence of events. Conclusions – In low-risk post-AMI patients the presence of frequent ventricular arrhythmias or silent ischemia is associated with an unfavorable prognosis. The study of HRV was not shown to be useful in the risk stratification of these patients.

Qualquer experiência humana pode ser sacralizada, continuando na sua superfície profana. O caráter sagrado lhe vem da atribuição do mistério que oculta. Este mistério pode ser de beleza ou de feiúra, de bondade ou de maldade, de segurança ou de pecado, de anjo ou de demônio, no templo ou na rua. O sagrado opera uma transformação nas coisas do mundo tornando uma realidade inteiramente diferente das realidades naturais. O presente trabalho se propõe analisar numa perspectiva antropológica a hierofonia construída e reelaborada na Noite dos Tambores Silenciosos, numa tentativa de compreender o desenvolver deste processo. / Any human experience can become sacred and even go continuing going externally continue in its profane expression. This sacred character comes out to it human experience from the mystery touch that it the above mentioned human experience hides within itself. This mystery can enclose beauty or ugliness, goodness or wickedness, safety or sin, angles or devils, temples or street. The sacred one produces, accomplishes a certain transformation in the worldly things, turning them into a reality wholly different from an analyzing, departing from an anthropological perspective, the hidden hierophany, contacted and reworked out from Noite dos Tambores Silenciosos i. e: Night of the Silent Drums in great attempt of understanding and developing this process.

Syfte: När städerna växer i allt snabbare takt behövs nya platser att bygga bostäder på. De kommuner som växer väljer allt oftare att bebygga platser som tidigare ratats på grund av bland annat buller. Från statens sida finns det krav på hur stor bullernivån får vara. Kraven har sitt ursprung i att över två miljoner svenskar utsätts för buller dagligen. Buller kan leda till hälsoproblematik, i form av sömnstörningar och hjärt- och kärlsjukdomar. För att minska hälsoproblemen görs bullerutredningar, där förslag hur bullernivåerna kan minskas ges. Syftet med arbetet är att ge läsaren kunskap i vilka faktorer som påverkar bullerutredningar och tillvägagångssättet vid valet av bullerreducerande åtgärder så att byggnation närmare trafikerad väg kan möjliggöras. Metod: De metoder som använts i arbetet är litteraturstudie, dokumentanalys och intervjuer. Den litteratur som samlats in består av vetenskapliga artiklar. Dokumenten består av bullerutredningar genomförda av olika företag på olika platser i Sverige. Utifrån bullerutredningarna har personer att intervjua valts. De personer som intervjuats har utfört några av de bullerutredningar som använts i dokumentanalysen. Resultat: För att besvara rapportens syfte ställdes tre frågeställningar upp. Den första frågeställningen behandlar bullerreducerande tekniker, vilka tekniker som används idag. I rapporten framkom det att det finns ett flertal sätt att reducera buller. I följande ordning rangordnas de som mest frekvent använda: tyst sida, bullerskärm, hastighetsminskning, avstånd mellan hus och väg, vegetation, flytt av väg och tyst asfalt. I rapportens andra frågeställning behandlas vilka faktorer som påverkar valet av bullerreducerande åtgärd. Från litteraturstudien framkom absorption, reflektion och reduktion som viktiga faktorer. I dokumentanalysen framkom omgivning, trafik och hastighet som viktiga faktorer. I intervjuerna framkom estetik och pris som viktiga vid val av reducerande åtgärd. I den tredje frågeställningen behandlas frågan om hur byggnation närmare väg kan möjliggöras. I resultatet framkommer det att alla lösningar som tidigare nämnts har förmåga att reducera buller, men hur effektiva de är och hur bra de reducerar buller varierar från fall till fall. Omgivning och trafikmängd har stor betydelse. Konsekvenser: Att utnyttja de tekniska lösningar som tidigare beskrivits ger en minskad bullernivå och således kan byggnation nära trafikerad väg möjliggöras. Att utföra en bullerutredning i ett tidigt skede medför att senare och dyrare ändringar kan undvikas, vilket gör att byggnationen kan ske snabbare. Rapporten föreslår att bullerproblematiken ska beaktas tidigt i projekt, detta för att skapa en lösning som alla i projektet kan acceptera. Begränsningar: Rapportens resultat är begränsat till ett mindre urval av bullerutredningar och intervjuer. Fler utredningar och intervjuer hade bidragit till ett större spektrum. Rapporten tar enbart hänsyn till buller utomhus och vilka möjligheter till bullerreduktion det finns. / Purpose: When cities grow at a faster rate, new places are needed to build housing.The municipalities that are growing tends to choose build sites that previously wererejected due to noise pollution. There are requirements from the state that the noise maynot exceed certain values. The requirements originate from the fact that over twomillion swedes are exposed to noise daily. Noise can lead to health problems, in theform of sleep disorders and cardiovascular disease. To reduce health problems noiseinvestigations are made, where suggestions are made in how noise levels can bereduced. The purpose of the work is to provide the reader with knowledge of whichfactors influence noise investigations and the approach to the choice of noise reductionmeasures so that construction can be made closer to trafficked roads. Method: The methods used are literature studies, document analysis and interviews.The literature gathered consists of scientific articles. The documents consist of noiseinvestigations conducted by different companies all over Sweden. Persons to interviewwere chosen from the conductors of the noise investigations documents. Findings: To answer the report's purpose, three questions were raised. The firstquestion deals with noise-reducing technologies and which technologies are used today.The report found that there are several ways to reduce noise. In the following order, themost frequently used are: silent facade, noise screen, speed reduction, distance betweenhouse and roads, vegetation, road moving and quiet asphalt. The second question of thereport addresses the factors that influence the choice of noise reduction measure. Fromthe literature study, absorption, reflection and reduction were found to be importantfactors. In the document analysis, surroundings, traffic and speed emerged as importantfactors. In the interviews, aesthetics and price emerged as important in the choice ofwhich reducing action should be taken. The third question deals with the question ofhow construction can be made closer to the road. In the result it appears that all of thesolutions mentioned earlier have the ability to reduce noise, but how effective they areand how well they reduce noise varies from case to case. Surroundings and trafficvolume are of great importance. Implications: Making use of the technical solutions previously described, results in areduced noise level and there for construction near road can be made possible.Executing a noise investigation at an early stage means that later and more expensivechanges can be avoided, which means that construction can take place sooner. Thereport suggests therefore that noise issues should be considered early in projects. It isalso important to get a solution that everyone can accept. Limitations: The report's results are limited to a smaller selection of noiseinvestigations and interviews. More investigations and interviews could hadcontributed to a larger spectrum. The report does only consider noise outdoors and whatopportunities for noise reduction there are.

Esta pesquisa procura investigar o processo de projeto na arquitetura e como o mesmo passou a ser influenciado nas últimas décadas pelas ferramentas digitais que surgiram desde então. Busca estabelecer uma visão sobre o projeto arquitetônico questionando a existência de um novo paradigma. Para isso analisa a produção acadêmica brasileira dos últimos anos que exploraram ou desenvolveram teorias sobre a utilização de ferramentas digitais afim de estabelecer um ponto de partida. Através da bibliografia expõem uma visão e uma defesa de uma forma de projetar e de como as ferramentas digitais podem auxiliar este processo sem criar deturpações de uso. Por fim o texto contrapõem duas arquiteturas: a arquitetura silenciosa - sóbria - que busca adequar-se à cidade e tão bem aguenta o passar do tempo e a arquitetura digitalista, focada no "inusitado", que está muito mais voltada à possibilidade de exploração midiática da edificação e que tantos problemas traz aos usuários e à sociedade. / This research investigates the design process in architecture and how it came to be influenced in the past few years by digital tools which emerged since then. It seeks to establish a vision about the architecture design methods by questioning the existence of a new paradigm. Thereunto it analyzes the Brazilian academic production of the past few years which explored or developed theories about the use of digital tools in order to establish a starting point. Through literature, it exposes a vision and a defense of a way of designing and how digital tools can assist this process without creating distortions of its use. Finally, the text contrasts two types of architecture: the silent, sober architecture, which seeks to adapt to the city and as well support the passage of time and changes of its uses, and the "digitalist" architecture, focused on the "unusual", which turns to the possibility of the media exploitation of the building and the many problems it brings to users and society.

Esta pesquisa procura investigar o processo de projeto na arquitetura e como o mesmo passou a ser influenciado nas últimas décadas pelas ferramentas digitais que surgiram desde então. Busca estabelecer uma visão sobre o projeto arquitetônico questionando a existência de um novo paradigma. Para isso analisa a produção acadêmica brasileira dos últimos anos que exploraram ou desenvolveram teorias sobre a utilização de ferramentas digitais afim de estabelecer um ponto de partida. Através da bibliografia expõem uma visão e uma defesa de uma forma de projetar e de como as ferramentas digitais podem auxiliar este processo sem criar deturpações de uso. Por fim o texto contrapõem duas arquiteturas: a arquitetura silenciosa - sóbria - que busca adequar-se à cidade e tão bem aguenta o passar do tempo e a arquitetura digitalista, focada no "inusitado", que está muito mais voltada à possibilidade de exploração midiática da edificação e que tantos problemas traz aos usuários e à sociedade. / This research investigates the design process in architecture and how it came to be influenced in the past few years by digital tools which emerged since then. It seeks to establish a vision about the architecture design methods by questioning the existence of a new paradigm. Thereunto it analyzes the Brazilian academic production of the past few years which explored or developed theories about the use of digital tools in order to establish a starting point. Through literature, it exposes a vision and a defense of a way of designing and how digital tools can assist this process without creating distortions of its use. Finally, the text contrasts two types of architecture: the silent, sober architecture, which seeks to adapt to the city and as well support the passage of time and changes of its uses, and the "digitalist" architecture, focused on the "unusual", which turns to the possibility of the media exploitation of the building and the many problems it brings to users and society.

O grande grupo heterogêneo de neuropatias periféricas hereditárias estão entre os casos mais comuns de perda sensitiva e fraqueza muscular em crianças e adolescentes. Pelo menos 84 genes estão envolvidos com neuropatias sensitivo-motoras hereditárias (NSMH), sendo suas formas de herança mais comuns as autossômico-dominantes desmielinizante e axonal e as neuropatias ligadas ao cromossomo X, e as mais raras as autossômicorecessivas desmielinizante e axonal e as formas ainda não classificadas. O gene HINT1, possuinte de 3 exons e localizado no cromossomo 5, codifica a proteína Histidine triad nucleotide binding protein 1, uma variante transcricional (mRNA) regulatória que hidroliza substratos. Recentemente mutações em HINT1 foram também relacionadas à neuropatias axonais com neuromiotonia (ARCMT2-NM), e portanto à CMT. O objetivo deste trabalho foi realizar o screening mutacional do gene HINT1 em uma amostra da população brasileira com quadro clínico de CMT recessivo (CMT2-AR), e foram encontradas 1 mutação silenciosa já previamente descrita, 1 polimorfismo exônico e 1 polimorfismo intrônico, também já conhecidos. Concluiu-se que mutações no gene HINT1 não são portanto responsáveis pela CMT-AR nesta amostra da população brasileira. / The large heterogeneous group of inherited peripheral neuropathies are among the most common causes of sensory loss and muscle weakness in children and adolescents. At least 84 genes are involved in inherited sensorymotor neuropathies (NSMH), being the demyelinating and axonal autosomaldominant and the X-linked neuropathies their most common forms of inheritance, and the demyelinating and axonal autosomal-recessive and not yet classified forms the most rare ones. The HINT1 gene, with 3 exons and located on chromosome 5, encodes the protein Histidine triad nucleotide binding protein 1, a regulatory transcriptional variant (mRNA) that hydrolyzes substrates. Recently, mutations in HINT1 were also related to axonal neuropathy with neuromyotonia (ARCMT2-NM), and therefore to CMT. The objective of this study was the mutational screening of the HINT1 gene in a sample of the Brazilian population with clinical recessive CMT (CMT2-AR), and 1 silent mutation previously described, 1 intronic polymorphism and 1 exonic polymorphism, both also known, were founded. It was then concluded that mutations in the HINT1 gene are not responsible for CMT2-AR in this particular sample of the Brazilian population.

Orientador: Miriam Viviana Gárate / Vol. 2 possui o subtítulo: Antologia / Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Estudos da Linguagem / Made available in DSpace on 2018-08-25T20:11:21Z (GMT). No. of bitstreams: 2 Carvalho_DanielleCrepaldi_D.pdf: 3217312 bytes, checksum: cf4e438c01673565f6e2b8524181c9e9 (MD5) Carvalho_DanielleCrepaldi_D_Anexo.zip: 32363002 bytes, checksum: 46f32947f82c7a68cb70805dca0e7271 (MD5) Previous issue date: 2014 / Resumo: Esta tese compila e analisa a prosa cronística a respeito do kinetoscópio/ cinematógrafo, publicada em periódicos cariocas de 1894 a 1922 - dos primórdios dos media até o estabelecimento do cinema enquanto indústria sólida e arte. Debruça-se sobre uma questão candente postulada neste período que vai da entrada do kinetoscópio no Brasil até o burilamento do star system: aquela que diz respeito ao "realismo" cênico; passo fundamental na transformação do cinema norte-americano em uma das principais indústrias de seu país. O "realismo" das imagens em movimento, desde logo assinalado semanticamente pela denominação de "objetiva" atribuída às lentes que as captavam, enredou os cronistas desde a chegada do invento ao Brasil. O estudo centra-se no modo como esse realismo foi experimentado e pensado por escritores como Arthur Azevedo, Paulo Barreto/João do Rio, Olavo Bilac, Elvira Gama, Figueiredo Coimbra, Eva Canel, Baptista Coelho, Figueiredo Pimentel e Graça Aranha. O eixo da pesquisa visa a estabelecer como o kinetoscópio e o cinematógrafo moldaram o olhar dos cronistas à cidade e, em especial, às ruas do Rio de Janeiro, naqueles anos em que as vielas acanhadas da cidade provinciana transformavam-se em vias elegantes abertas como palcos, a convidarem a "sociedade" a trocar o âmbito privado pela flânerie pública. O trabalho procura analisar estruturalmente e tematicamente os textos cronísticos, no diálogo que estabeleceram com as produções cinematográficas vistas na capital. Lança-se, portanto, num trabalho interdisciplinar, que procura ler o cinema a partir das múltiplas relações estabelecidas com as produções culturais de seu tempo: o gênero teatral, a mise-en-scène dos museus, os panoramas pintados, o romance folhetinesco, a notícia jornalística, etc. Falamos, pois, de um percurso de mão dupla entre encenação e realidade, segundo o qual o "real" é encenado tendo-se por base convenções cênicas e literárias já solidificadas / Abstract: This thesis compiles and analyses the chronicle regarding the kinetoscope/ cinematograph published in carioca's newspapers and magazines from 1894 to 1922 - from the beginning of these media up to the establishment of the cinema as both a solid industry and as an art form. It aims to deal with a big issue of this period of time that goes from the arrival of the kinetoscope in Brazil until the development of the star system: the scenic "realism"; a fundamental step for the transformation of the North American cinema in one of the most important industries of the USA. The "realism" of the moving pictures, semantically determined by the name given to the cinematographic lenses - "objective" - moved Brazilian newspapers writers from the beginning. This piece of work centers in the way this realism was experimented and though by writers such as Arthur Azevedo, Paulo Barreto/João do Rio, Olavo Bilac, Elvira Gama, Figueiredo Coimbra, Eva Canel, Baptista Coelho, Figueiredo Pimentel and Graça Aranha. The goal of the research is to establish how the kinetoscope and the cinematograph gave form to the way writers observed the city in general, and specially the streets of Rio de Janeiro in those years when the unbreathable alleys of the provincial city turned into long and elegant avenues built up as open stages - inviting the "Society" to give up private habits to public ones. This study regards the chronicles considering their structure and themes, and the dialogue they established with the moving pictures seen in Rio. Therefore, it's driven into an interdisciplinary job, regarding the cinema from the multiples relations it established with the cultural production of its time: the theater plays, the museums' mise-en-scène, the painting "panoramas", the newspaper novels and reports, etc. We're talking about a two-way path between staging and reality, according to which "real" is staged using as a model solid scenic and literary conventions / Doutorado / Historia e Historiografia Literaria / Doutora em Teoria e História Literária

The submitted thesis deals with the matter of reading comprehension in pupils with autism spectrum disorders. The thesis is divided into the theoretical and empirical part. In the theoretical part we dealt with the issue of autism spectrum disorders, constituent diagnoses and the triad of disrupted areas. Further into thesis we presented the reader the fundamental cognitive theories which explain exhibitions within the range of autism spectrum disorders. Towards the end of thesis we dealt with reader's literacy with special emphasis on reading comprehension. The second part presents empirical research aimed at ascertainment of reading comprehension in pupils with autism spectrum disorders. The research sample consisted of sixth and ninth grade pupils diagnosed with Asperger syndrome from both primary and grammar school. The sample was supplemented with a control group which comprised intact pupils of the same grades. For the purposes of this study there were created new tests focusing on the level of reading comprehension. The first test aimed at reading comprehension with regard to silent reading, the second test observed reading comprehension in terms of loud reading. Methodology was further supplemented with the Strange Stories test ascertaining the level of theory of mind. The crucial part of...

The phenomenon of orphans and vulnerable children (OVC) in Zambia is a consequence of the HIV and AIDS epidemic. Many of these children are orphaned at a critical developmental stage of their lives when parental care and nurture is most needed. In the African world view, children’s opinions in matters concerning them including care are rarely sort or heard. The main aim of this research was to gain a holistic understanding of the silent voices of children affected and/or infected by the HIV and AIDS, and specifically about their experiences of care and/or lack of it. The other aims were: 1) to research alternative means of getting the silent stories of the marginalized children heard by the Zambian society; and 2) to disseminate the research findings to policy makers. Ten children orphaned by AIDS and vulnerable children, who are the core-searchers, drawn from three Lusaka urban based NGOs participated in the study. The research process and experience was reflected upon by the researcher, co-researchers and the care givers. The research was carried out from a Practical Theology perspective and the narrative approach within the postmodern social-constructionist paradigm. The ABDCE model for fiction writing as a metaphor for doing narrative research was used. This approach enabled the researcher to carry out the research in a systematic manner. It also allowed the researcher and the co-researchers to begin and work together throughout the research process, as the researcher listened to the co-researchers’ stories and experiences of care and/or lack of it and was drawn into them. / Thesis (PhD)--University of Pretoria, 2012. / Practical Theology / unrestricted

La fibrillation atriale (FA) est une complication fréquente de la phase aiguë de l’infarctus (IDM) avec un moins bon pronostic des patients. Sa forme silencieuse pourrait être fréquente après un IDM. Cependant, toutes les études ayant porté sur la FA se sont focalisées sur les formes symptomatique, paroxystique ou persistante. De plus, la réduction de la biodisponibilité du •NO et la dysfonction endothéliale peuvent altérer le pronostic des patients en FA. Or, l’asymétrique diméthylarginine (ADMA) en inhibant de façon endogène l’action des NO synthases peut conduire à une dysfonction endothéliale, une inflammation ou encore à un stress oxydatif, qui sont impliqués dans de nombreuses pathologies cardiovasculaires. Cependant, au-cune étude n’a évalué la relation potentielle entre le taux plasmatique d’ADMA et la survenue d’une FA après un IDM.Notre objectif a été d’évaluer dans le cadre d’une étude prospective le pronos-tic hospitalier et à un an des patients présentant de la FA silencieuse en phase ai-guë d’IDM, et évaluer le lien potentiel entre les dimethylarginines et l’apparition d’une FA. Notre première étude prospective montre pour la première fois que la FA si-lencieuse est plus fréquente que la FA symptomatique et est associée à un moins bon pronostic après un IDM.Notre second travail, démontre que l’impact négatif de la FA silencieuse sur le pronostic des patients se maintient à un an après l’IDM.Notre troisième travail montre également, que l’ADMA est associée de ma-nière indépendante à la survenue d’une FA symptomatique après un IDM. Ces données suggèrent qu’un dépistage et qu’une prise en charge spécifiques de la FA après un IDM pourraient améliorer le pronostic des patients. L’ADMA pourrait ainsi être utilisée comme un marqueur de risque de passage en FA après un IDM. / Atrial fibrillation (AF) is a frequent complication of acute myocardial infarction (AMI) with a poorer prognosis. Silent atrial fibrillation has been suggested to be frequent after AMI. However, most part of the studies has targeted only paroxysmal or persistent AF. Thus, Reduced Nitric Oxide availability and endothelial dysfunction has been recently recognized as a possible contributor to altered prognosis in AF. Asymmetric dimethylarginine (ADMA) can inhibit nitric oxide synthase and leads to endothelial dysfunction, inflammation and oxidative stress in multiple cardiovascular diseases. However, any study has addressed the relationship between ADMA levels and the occurrence of AF in AMI.We aimed to assess in-hospital and 1-year prognosis in patients experiencing silent AF in AMI and evaluate the potential relationship between dimethylarginines plasma levels and the occurrence AF after acute myocardial infarction.Our first prospective study shows for the first time that silent AF is more frequent than symptomatic AF after AMI and is associated with a worse prognosis.Our second work confirms the impact of silent AF on prognosis, with a prognosis that remains worse one year after the acute phase of MI. Our third work proved that ADMA is independently associated with symptomatic AF after AMI and strengthen the capacity to estimate symptomatic AF occurrence. In conclusion our studies highlight that AF is not a negligible event after AMI, in particular silent AF. That suggests that systematic screening and specific management should be investigated in order to improve outcomes of patients. ADMA appears to be a potential predictor of AF after AMI, because of its significant association.