What are appropriate and relevant ways for collaboration and coordination between the three sections of aid work, humanitarian, development, and peace? This question has been topical for the aid community for decades when working in places where all three entities are present (Guinote, 2019). It is sometimes rejected, neglected but some times it is also considered and pursued (Hövelmann, 2020). This study aims to assess and analyze the arguments and breeding grounds for the triple nexus approached work in the DRC, the dynamics of promoting and receiving directions in a headquarters-field office relation exploring the challenges and opportunities between the three sections of HDP. Assessments have been done through conducting interviews remotely with people working on-site in the DRC at national or local offices and headquarters in Sweden and Central Europe. By interviewing eleven people with experience from all three HDP sectors, where a few people come from the donor sector, the goal has been to provide a broad picture of the aid community's perspective. This study's findings and inferences are related to funding structures where a more flexible funding system is requested. There are local involvement findings where signs through this study indicate local initiatives have been implementing the nexus approach for years. In environments such as presented in this study, of interrelating groups of people with differences in working culture, there are also challenges of clashing organizational principles, hegemonic approaches, and the ever topical issue of clear and relevant communication presented in the thesis. Through this assessment, power structures are pertinent to analyze to understand how the triple nexus approach can be further implemented. The agency theory will, in this study, be used as an eyeglass to assess these power relations.

A shift has occurred in the traditional type of centralised government control to a more multilevel type of governing referred to as governance. The change from government to governance can be illustrated with an emphasis on networks and social capital enhancement. In higher education this is enveloped through a larger emphasis on institutionalisation of collaboration between the higher education institutions (HEI) and the surrounding environment. In lieu of large block grants come financial incentives through semi-governmental agencies embracing collaboration projects between industry and HEI as well as municipalities.` This licentiate thesis objective is to study the collaboration task’s practical implication on undergraduate education in terms of social capital enhancement and research and teaching links. This is reported in two articles that elaborate on social capital establishment through a policy program and whether policy programs focusing on research collaborations also have an effect on undergraduate education by improving research and teaching links. In general, the findings of this thesis indicate that semi-governmental policy programs have a positive effect on establishing new social capital between regional HEI, industry and municipalities, and that semi-governmentally financed research profiles also have a positive effect on undergraduate education by introducing a link to research outside and within the HEI. / QC 20110117

FPGAs are frequently used in network systems to provide the performance and flexibility that is required of modern computer networks while allowing network vendors to bring products to market quickly. Like all electronic devices, FPGAs are vulnerable to ionizing radiation which can cause applications operating on an FPGA to fail. These low-level failures can have a wide range of negative effects on the performance of a network system. As computer networks play a larger role in modern society, it becomes increasingly important that these soft errors are addressed in the design of network systems.This work presents a framework for testing the soft-error reliability of FPGA-based networking systems. The framework consists of the NetFPGA development board, a custom traffic generator, and a custom high-speed JTAG configuration device. The NetFPGA development board is versatile and can be used to implement a wide range of network applications. The traffic generator is used to exercise the network system on the NetFPGA and to determine the health of that system. The JTAG configuration device is used to manage reliability experiments, to perform fault injection into the FPGA, and to monitor the NetFPGA during radiation tests.This thesis includes soft-error reliability tests that were performed on an Ethernet switch network system. Using both fault injection and accelerate radiation testing, the soft error sensitivity of the Ethernet switch was measured. The Ethernet switch design was then mitigated using triple module redundancy and duplication with compare. These mitigated designs were also tested and compared against the baseline design. Radiation testing shows that TMR provides a 5.05x improvement in reliability over the baseline design. DWC provides a 5.22x improvement in detectability over the baseline design without reducing the reliability of the system.

Sedan ett antal år tillbaka väljer allt fler att bo i innerstaden med små barn. Det har skapat ett enormt behov av nya förskoleplatser. Den vanligaste lösningen har blivit paviljonger med tillfälligt bygglov där antalet moduler monteras efter behov.  Med denna flexibla möjlighet tycks dock barackerna ha kommit för att stanna och blir oftast något helt annat än den provisoriska lösning de en gång var ämnade för.   Ett annat problem som förskolan står inför är att maten inte tillagas på plats utan körs ut från storkök och levereras i värmeslådor. Det fungerar förvisso men den pedagogiska poängen går om intet.   Syftet med projektet har varit att rita ett dagis i Stockholms innerstad som med samutnyttjade funktioner ger ett flexibelt förslag. Till förskolan hör ett restaurangkök som också serverar en restaurang, öppen för allmänheten. Kvällstid används vissa av barnens lokaler till en dansstudio. Samutnyttjandet blir kärnan och drivkraften i projektet.   Tomten är belägen i ena hörnet av Tantolunden på Södermalm.  Den avgränsas av bilväg och tågspår samt stora nivåskillnader. Buller och trafikfaror är påtagliga. Samtidigt delar den norra sidan ett fantastiskt parkläge med den kulturmärkta Ekermanska malmgården som funnits flera hundra år på platsen.   Att bygga i park är kontroversiellt och byggnaden har därför fått som uppgift att tydliggöra platsen som i nuläget är svåranvänd. Med publika verksamheter mot Ringvägen blir den en destination istället för en passage. Med en förlängning av Ekermanska gårdens riktning definieras också parkrummets gräns. Volymen i sig omsluter en innergård som blir barnens trygga oas. / An increasing number of families with small children are now choosing to live in Stockholm’s inner city, which has led to a tremendous need for more pre-schools. The most common solution today is to use pavilions with temporary building permits where modules are assembled as required from time to time. As they provide such a flexible solution, these barracks are however often being used in a permanent manner, quite different from the interim solution they were once intended to be.   Another problem that pre-schools face is that the children’s food is not cooked on location, but is instead prepared in industrial kitchens and delivered to the pre-schools. Although this is a viable solution, it does not fulfill the intended educational objective. The purpose of this project has been to design a pre-school in Stockholm’s inner city which provides a flexible option due to co-usage features. The pre-school’s kitchen also caters a restaurant which is open to the public. In the evenings, part of the children's space is used as a dance studio. This co-usage of space and function becomes the core and driving force of the project.   The grounds of the pre-school are located in one corner of the park Tantolunden on Södermalm. One side of the grounds is adjacent to motor roads and railroad tracks and significant differences in level. Noise and traffic dangers are obvious. At the same time, the north side of the grounds shares an amazing park with the heritage listed Ekermanska malmgården which has existed at this site for centuries. Building in parks is controversial and the building has therefore been given the task of clarifying this site, which is currently difficult to use. By providing businesses open to the public along Ringvägen, it becomes a destination instead of merely a place of transit. By providing an extension of Ekermanska malmgården's direction, the boundaries of the park are also defined. The volume itself encloses a courtyard that becomes the children's safe haven.

This thesis covers the utilization of N buffers in order to reduce resource contention on an abstract WebGL machine, and subsequently freeing up machine processing time. The buffers touched are frame buffers and vertex buffers. The paper also briefly covers the purpose and function of N buffering in relation to graphics and the function of a WebGL machine, the research and production of benchmark prototypes, some relevant benchmark results, and analysis and conclusions. The conclusion is made that the use of N>1 buffering is a potentially viable strategy for increasing WebGL performance, and some theories are outlined and suggestions given for further research to be made for the resolving of how this performance gain may be improved. / Denna uppsats granskar nyttjandet av N buffrar för att minska uppkomsten av resurskonflikter på en abstrakt WebGL maskin, och således frigöra processtid på maskinen i fråga. De typer av buffrar som vidrörs är så kallade frame buffers och vertex buffers. Uppsatsen går också igenom syftet och funktionen hos N buffrar i relation till grafik och funktionen hos en WebGL maskin, förstudien kring och produktionen av prestandatest-prototyper, en del relevanta mätresultat, samt analys och slutsatser. Slutsatsen nås att nyttjandet av N>1 buffrar är en potentiellt gångbar strategi för ökandet av prestanda hos WebGL, och en del teorier presenteras och förslag ges kring ytterligare studier för attöka prestanda ytterligare.

No description available.

The theme of my thesis is looking into phenomenon of social enterpreneurship in relation to associations. My aim was to determine how associations devote social businesses in the Czech Republic. The theoretical section is mainly used to understand the basic concepts and related to social enterpreneurship. Based on research, my aim was to find the ideal conception of social enterprise for the Czech environment. The empirical section presents examples of good practise through specific associatins and their business. I verify the ideal conception of social enterprise through associations and I am interested in whether that social business could obtain additional funding to associations. The escalation of my thesis are recommendations for associations on how to become a successful social entreprise.

Regulatorische CD4+CD25+ T-Zellen (Tregs) stellen eine kleine Zellpopulation dar (1-5% der peripheren Blutzellen), die hauptsächlich für die Regulierung von Immunreaktionen verantwortlich ist. In der vorliegenden Arbeit wurden diese Zellen gemeinsam mit Stammzellen syngen und allogen kotransplantiert, um ihren Effekt auf das Anwachsen der Spenderzellen und die Rekonstitution der Hämatopoese nach Ganzkörperbestrahlung zu untersuchen. Es wurden humanisierte dreifach transgene Empfängermäuse (C57Bl/6-TTG) verwendet (human CD4+, murin CD4-, human HLA-DR+), wodurch sowohl bei syngener als auch bei allogener Transplantation eine Unterscheidung zwischen Spender- und Empfängerzellen möglich ist. Zunächst wurden CD4+CD25+ T-Zellen durch Separation aus Milzzellen bzw. Buffy Coats gewonnen und in vitro mittels Durchflusszytometrie und ELISpot charakterisiert. Anschließend fanden syngene und allogene Transplantationen mit einer Laufzeit von 61 Tagen statt. Überleben und Gewicht wurden täglich ermittelt und außerdem wurden wöchentlich Blutbilder erstellt und durchflusszytometrische Chimärismusanalysen (murines und humanes CD4, CD8, MHC (H2Db, H2Kd)) durchgeführt. Durch die magnetische Separation konnte die FoxP3-Expression der murinen Zellen (Transplantat) von 1,6% in der Ausgangspopulation auf 68,5% in der CD4+CD25+ Population gesteigert werden. In den ELISpot-Assays zeigten diese separierten Zellen, wie für Tregs typisch, keine Produktion von Interleukin-2. Nach syngener Transplantation (Spender: wildtyp C57Bl/6) von 2x106 Knochenmarkzellen und 1x106 CD4+CD25+ T-Zellen überlebten 100% der Tiere, wie zu erwarten war. Dabei setzte bei Tregs-kotransplantierten Tieren die Blutbildung nach bestrahlungsbedingter Leukozytopenie aufgrund bisher nicht bekannter Mechanismen früher wieder ein und der Donor-Zell-Chimärismus war an Tag 19 nach Transplantation signifikant höher als in der Kontrollgruppe. Dies zeigt, dass regulatorische T-Zellen im syngenen Transplantationsmodell einen positiven Effekt auf die Akzeptanz bzw. das Anwachsen des Transplantats haben. Dieses Modell entspricht klinisch einer autologen Transplantation. Nach einer knochenmarkzerstörenden Therapie werden dem Patienten eigene Stammzellen reinfundiert, um die Blutbildung und das Immunsystem wieder in Gang zu bringen. Der Zusatz von regulatorischen T-Zellen zum autologen Stammzelltransplantat könnte das Anwachsen der Zellen beschleunigen und die gefährliche Phase der Immunsuppression, in der es häufig zu Sekundärinfektionen kommt, verkürzen. Die Transplantation der gleichen Zahl von allogenen Spenderzellen (wildtyp Balb/c) führte überraschend zum Tod aller dreifach transgenen Empfängertiere. Der Vergleich zu Experimenten mit wildtyp C57Bl/6-Empfängertieren zeigte, dass dreifach transgene Mäuse sehr viel höhere Zellzahlen im Transplantat zum Überleben benötigen (Daten nicht gezeigt). Das Ausbleiben der Blutbildung nach der Bestrahlung führte zu vermindertem Allgemeinbefinden, gestörter Futter- und Wassseraufnahme und Exsikkose bis zum Tod bzw. aus Tierschutzgründen zur Euthanasie. Durch Erhöhung der Zellzahl im Transplantat auf 1x107 Knochenmark + 5x106 Milzzellen überlebten 25% der Mäuse, bei 3x107 Knochenmark + 5x106 Milzzellen waren es 50%. Anders als im syngenen Modell führte die Kotransplantation 1,5x106 allogener CD4+CD25+ T-Zellen zu 3x107 Knochenmark + 5x106 Milzzellen zum Versterben der Tiere. Dies verdeutlicht, dass regulatorische T-Zellen in diesem allogenen Transplantationsmodell das Anwachsen des Transplantats behindern (Transplantatversagen). Hier gilt es zu klären, ob dieser Effekt spezifisch für die gewählten Mausstämme ist und welche Mechanismen für das Transplantatversagen verantwortlich sind. In einem dreifach transgenen Mausmodell konnte ein positiver Effekt von regulatorischen T-Zellen auf die Rekonstitution der Hämatopoese bei syngener Kotransplantation nachgewiesen werden. Im allogenen Transplantationsmodell hingegen führte die Kotransplantation CD4+CD25+ T-Zellen zum Versterben der Empfänger. Der beschriebene und schon publizierte positive Effekt spenderspezifischer Tregs zur Behandlung von Graft versus Host Disease nach allogener Stammzelltransplantation widerspricht diesen Ergebnissen nicht, da es bei diesen Patienten schon zum Engraftment von hämatopoetischen Stammzellen gekommen ist. Dies hat weitreichende Konsequenzen für die therapeutische Anwendung regulatorischer T-Zellen bei hämatologischen Erkrankungen in der Human- und Veterinärmedizin. / Regulatory CD4+CD25+ T cells (Tregs) represent a small cell population (1-5% of peripheral blood cells) mainly responsible for the regulation of the immune system. In the present work, these cells were cotransplanted with syngeneic and allogeneic stem cells in order to analyze the effect of Tregs on the reconstitution of hematopoiesis after total body irradiation. Humanized triple transgenic hosts (C57Bl/6-TTG) (human CD4+, murine CD4-, human HLA-DR+) were applied allowing differentiation of donor and host cells in syngeneic and allogeneic transplantation settings. Murine and human CD4+CD25+ T cells were magnetically separated out of splenocytes or buffy-coats and characterized in vitro by means of flow cytometry and ELISpot. Afterwards syngeneic and allogeneic transplantation experiments were performed for a period of 61 days. Survival and weight were assessed daily and once a week blood parameters and chimerism analyses (murine and human CD4, CD8, MHC (H2Db/ H2Kd)) were carried out. FoxP3 expression increased from 1,6% in the initial murine cell fraction to 68,5% in the separated CD4+CD25+ T cells. ELISpot assays showed the typical lack of interleukin 2 production of Tregs. After syngeneic transplantation (donor: wildtype C57Bl/6) of 2x106 bone marrow cells and 1x106 CD4+CD25+ T cells, 100% of mice survived what was to be expected. Cotransplanted animals showed earlier reconstitution of hematopoiesis after leukocytopenia and significant higher donor-cell-chimerism on day 19 after transplantation. The mechanisms for this positive effect of Tregs in syngeneic transplantation on the engraftment have to be investigated. This model clinically correspond an autologous transplantation where patients are treated with their own stem cells after a myeloablative treatment (chemotherapy or irradiation). The addition of regulatory T cells to the transplant could accelerate the engraftment and shorten the risky period of immunosuppression. Injection of the same numbers of allogeneic cells (donor: wildtype Balb/c) did not preserve hosts from mortality. Compared to experiments with wildtype recipients, results showed that triple transgenic mice need much higher cell numbers in the transplant for survival (data not shown). The failure of hematopoiesis after irradiation led to reduced general condition, disordered ingestion and exsikkosis leading to death respectively to euthanasia for reasons of protection of animals. By scaling up the cell number in the inoculum to 1x107 bone marrow cells + 5x106 splenocytes 25% of mice survived, with 3x107 bone marrow cells + 5x106 splenocytes survival was 50%. In contrast to syngeneic experiments, cotransplantation of 1,5x106 allogeneic CD4+CD25+ T cells and 3x107 bone marrow cells + 5x106 splenocytes did not prevent animals from mortality. In this allogeneic transplantation model Tregs restrain engraftment (graft failure). It has to be clarified if this effect is specific for the utilized mouse strains and which mechanisms are responsible for the graft failure. In the syngeneic triple transgenic mouse model cotransplantation of CD4+CD25+ T cells showed a positive effect on reconstitution of hematopoiesis after irradiation. In the allogeneic setting however cotransplantation of allogeneic regulatory T cells avoided the engraftment of transplanted cells. The described and published effect of donor-specific Tregs for treatment of graft versus host disease after allogeneic transplantation does not contradict the presented results because treated patients already possessed engrafted hematopoietic stem cells. The results have wide consequences for the therapeutic appliance of regulatory T cells in hematological diseases in human and veterinary medicine.

No description available.

Debates concerning the concept of 'engaged scholarship’ (ES) in terms of university-society connectivity have become part of the discourse within the shifting South African higher education landscape after 1994. Given the legacy of historical inequalities continuing to permeate all spheres of South African society including higher education, the idea of social-justice-centred engaged scholarship forms the main thrust of the narrative in this thesis. Furthermore, with music inherently geared towards societal engagement, and 'engaged scholarship’ included in UCT’s latest Social Responsiveness Policy Framework, this thesis critically examines the ES responses - in terms of their perceptions and practices - of music academics at the SACM in post-1994 South Africa. The opening chapter outlines the largely two-pronged research methodology approach pertaining to the analysis and findings of: (1) literature and documents, and (2) in-depth interviews of a representative sample of full-time SACM music academics. Chapter 2 provides a historical sociology unpacking the ES concept as part of an emergent University Third Mission. With developments largely unfolding at American universities, the first part of Chapter 2 shows the development of ES as essentially following two routes. Firstly the Triple Helix notion of university-industry-government (U-I-G) relations since the mid-20th century, identified by Etzkowitz as a 'Second Academic Transformation’ grafted on an earlier 19th century 'First Academic Transformation’ which began in Germany. Then secondly, in the 1990s a broadened view of scholarship aimed at making universities more relevant to the needs of society (i.e. via U-CS or university-civil society links) proposed by Boyer. With the issue of an emergent University Third Mission also entering the South African higher education discourse after 1994, the second part of Chapter 2 highlights conceptual confusion by considering policy and conference debates on 'community engagement’ (CE), the preferred expression for university-society relations in South Africa. Unfolding developments at UCT however have resulted in a discourse of ES becoming integral to this university’s Social Responsiveness Policy Framework after 2012. Moreover with social justice largely absent from CE discourse and the Triple Helix, Cooper has proposed a Quadruple Helix whereby civil society is added as fourth helix (i.e. resulting in U-I-G-CS). The approach of this study, therefore, explores the concept of a social-justice-centred engagement (outlined in part three of Chapter 2) with which it strongly resonates. Chapter 3 focuses attention on the milieu and ethos of UCT and the SACM, putting SACM music academics, part of an elite historically 'white’ university, in perspective. This highlights the entrenched hegemony of the historically 'white’ European settler institutional culture and 'orphan’ status of music indigenous to Africa at the SACM. Against this backdrop Chapter 4 provides a snapshot of the ES perceptions and practices of SACM music academics derived from the in-depth interviews. Importantly, with music largely absent from ES discourse, including at UCT, the critical analysis of the narratives of music academics form the basis for this thesis creating four music-specific ES categories in this chapter, and a proposed typology of music-specific ES in Chapter 5. In addition, a particularly important finding in Chapter 5 depicts the SACM as probably the most engaged UCT department, mainly displaying elements of the Quadruple Helix (U-I-G-CS), but with this engagement significantly skewed towards largely 'white’ civil society. Moreover, given the historically Eurocentric ethos of the SACM, western classical music has retained its uncontested hegemony (including within the SACM student curriculum) despite the introduction in the 1980s of new streams of non-western classical music, including music indigenous to Africa. With reference to ES, the engagement of the majority of SACM music academics was, furthermore, found overwhelmingly to be with the elite social classes. However, 'black’ academics were significantly more engaged with the 'black’ working class than their 'white’ counterparts. Considering the core findings above, pathways enabling the development of more balanced SACM-society relationships, particularly with the 'black’ working class majority have been proposed in the concluding chapter. A crucial recommendation is the decolonisation of the institutional culture and curriculum of the SACM, thereby restoring the former 'Other’, to 'Self’. These being spaces outside the comfort-zone of most music academics, it is suggested that music-specific ES research, potentially able to shift embedded reasoning, should become integral to the decolonisation process.