Global ETD Search

41	Evaluering van die Vienna toetsbattery in die voorspelling van effektiewe busbestuurder gedrag Du Toit, Martina Petronella 30 November 2006 (has links) Vehicle accidents by means of Public transport annually leads to a large number of passenger deaths and life long disablement. AsDu Toit, Martina Petronella a result, there is a need for preventative measures by identifying the psychomotor abilities of bus drivers during the recruitment and selection process of employment. The study was conducted among 398 bus drivers employed by a large bus company. The Vienna Test Battery was administered. It was found that distance estimation, ability to recognize forms and figures, concentration ability, eye-hand feet coordination and two-hand coordination predicted the effectiveness of bus drivers successfully. It is suggested that further research should focus on client services, attitude of bus drivers and learning potential, as factors that influence the effectiveness of bus drivers. / Industrial psychology / M.A. (Industrial Psychology) Bus driver Human abilities Prediction Vienna test battery Bus driver behaviour Psychomotor ability Accidents Distance estimation Two hand coordination Concentration ability Eye-hand-feet coordination Text in Afrikaans 150.287 Vienna Test System Bus drivers -- Ability testing Motor ability Eye-hand coordination Attention Traffic accidents Bus accidents
42	Predictive Relations Between Cognitive Abilities and Pilot Performance: A Structural Equation Modeling Approach Khalid S. Almamari (5930516) 31 July 2020 (has links) <p></p><p>A large body of literature suggests that cognitive abilities are important determinants for training and job performance, including flight performance. The associations between measures of ability tests and job performance have been the focus of many empirical studies, resulting in an overall conclusion that general mental ability, <i>g</i>, is the main source of prediction, while other narrower abilities have limited power for predicting job performance. Despite the attention given to cognitive ability-flight performance relationships, their associations have not been fully understood at the broad construct level, and most extant literature focused on the relations at the observed scores level. Thus, the present dissertation study was designed to contribute to the progression of this understanding by examining the relations between cognitive abilities and flight training performance, using data from four U.S. Air Force (USAF) pilot samples. For comparison, one navigator and one air battle manager sample were also analyzed. The data were obtained from correlation matrices of prior investigations and analyzed via structural equation modeling (SEM) procedures. </p> <p> Four studies are reported in the thesis: (1) preliminary study, (2) primary validation study, (3) cross-validation study, and (4) cross-occupation validation study. The preliminary study assessed the test battery used in the subsequent predictive studies. The primary validation study introduced a bifactor predictive SEM model for testing the influence of cognitive abilities in predicting pilot performance. The cross-validation study assessed the consistency of the predictive model suggested in the primary validation study, using three additional pilots’ samples. The cross-occupation validation study compared the predictive model using data from three aviation-related occupations (flying, navigation, air battle management). Ability factors were extracted from scores of pilot applicants on the Air Force Officer Qualifying Test (AFOQT), the USAF officers’ primary selection test battery, whereas the flight performance scores were obtained from pilot records during the flight training program.</p> <p> In addition to the <i>g</i> factor, <i>verbal ability, quantitative ability, spatial ability, perceptual speed ability, and aviation-related acquired knowledge </i>are the six latent cognitive ability factors investigated in the reported studies. Pilot performance measures were modeled either as observed or latent variables covering ratings of academic and hands-on flying performance in different phases of the training program. The studies of this thesis established that (1) general ability contributes substantially to the prediction models; however, it is not the only important predictor, (2) aviation-related acquired knowledge is the most robust predictor of pilot performance among the abilities examined, with a role even exceeding that of <i>g</i>, (3) perceptual speed predicted pilot performance uniquely in several occasions, while verbal, spatial, and quantitative abilities demonstrated trivial incremental validity for hands-on pilot performance beyond that provided by the <i>g</i> measure, and (4) the relative importance of cognitive abilities tends to vary across aviation occupations.</p><br><p></p> Applied Psychology Educational Psychology Industrial and Organisational Psychology Personality, Abilities and Assessment Cognitive Abilities Pilot Performance Structural Equation Modeling Selection Test Battery Criterion-related Validity bifactor modeling Correlated-factor Model Meta-analysis CFA EFA Aviation Psychology
43	Development of Sensitive In Vitro Assays to Assess the Ocular Toxicity Potential of Chemicals and Ophthalmic Products McCanna, David January 2009 (has links) The utilization of in vitro tests with a tiered testing strategy for detection of mild ocular irritants can reduce the use of animals for testing, provide mechanistic data on toxic effects, and reduce the uncertainty associated with dose selection for clinical trials. The first section of this thesis describes how in vitro methods can be used to improve the prediction of the toxicity of chemicals and ophthalmic products. The proper utilization of in vitro methods can accurately predict toxic threshold levels and reduce animal use in product development. Sections two, three and four describe the development of new sensitive in vitro methods for predicting ocular toxicity. Maintaining the barrier function of the cornea is critical for the prevention of the penetration of infections microorganisms and irritating chemicals into the eye. Chapter 2 describes the development of a method for assessing the effects of chemicals on tight junctions using a human corneal epithelial and canine kidney epithelial cell line. In Chapter 3 a method that uses a primary organ culture for assessing single instillation and multiple instillation toxic effects is described. The ScanTox system was shown to be an ideal system to monitor the toxic effects over time as multiple readings can be taken of treated bovine lenses using the nondestructive method of assessing for the lens optical quality. Confirmations of toxic effects were made with the utilization of the viability dye alamarBlue. Chapter 4 describes the development of sensitive in vitro assays for detecting ocular toxicity by measuring the effects of chemicals on the mitochondrial integrity of bovine cornea, bovine lens epithelium and corneal epithelial cells, using fluorescent dyes. The goal of this research was to develop an in vitro test battery that can be used to accurately predict the ocular toxicity of new chemicals and ophthalmic formulations. By comparing the toxicity seen in vivo animals and humans with the toxicity response in these new in vitro methods, it was demonstrated that these in vitro methods can be utilized in a tiered testing strategy in the development of new chemicals and ophthalmic formulations. in vitro Alternative Methods alamarBlue rhodamine tight junctions bovine lens viability toxicity mitochondria mitochondria integrity benzalkonium chloride sodium dodecyl sulphate sodium lauryl sulfate scanning electron microscopy Draize Draize maximal average scores zonula occludens cosmetic directive PETA humane society animal league ICCVAM ECVAM JaCVAM BCOP bovine cornea ocular irritants ocular irritation ocular toxicity human corneal epithelial cells vitro confocal confocal microscopy metabolic activity optical quality reactive oxygen species contact lens contact lens care solutions barrier function microbial keratitis mulitipurpose solutions tight junction cell damage claudin ZO-1 occludin MDCK Madin Madin-Darby canine kidney cells cornea human cornea human corneal epithelium epithelial cell line human corneal epithelial cell line sodium fluorescein sodium fluorescein permeability fluorescein permeability ocular surface cell monolayer Araki-Sasaki cell physiology risk assessment safety assessment ScanTox scanning laser lens epithelium corneal cells in vitro model ophthalmic formulations multiple instillation back vertex animal testing rabbit testing alternatives to animal testing cultured bovine lens toxicity of chemicals irritation irritants laser scanner organ culture delayed toxicity toxins hydrogen peroxide cornea toxicity cornea toxicity models prediction of human toxicity no observable adverse effect level lowest observable adverse effect level NOAEL LOAEL toxicity thresholds safety factors cornea uncertainty factors preservatives disinfectants ophthalmic products preclinical preclinical testing epithelial barrier drug penetration clinical confocal microscopy animal rights rabbit cornea human cornea human clinical effects toxic animal rights activist sensitive measures toxic effect toxicity threshold agar overlay agar diffusion agar overlay method agar diffusion method cytochrome cytochrome c apoptosis necrotic apoptotic necrosis caspase rhodamine 123 resazuran resorufin cell death cell viability metabolic dye microsomal microsomal enzymes cytotoxicity cytotoxic cytotoxic effect MTT XTT WST-1 plasma membrane mitochondrial mitochondrial morphology ocular toxicity potential ocular toxicity human corneal epithelial cell line confocal analysis corneal epithelium cell fluorescence alamarBlue assay rhodamine dye animal welfare toxic injury degraded mitochondria epithelial monolayer disinfectants membrane integrity eye toxicity eye viability dye toxicity in humans human toxicity effects on the mitochondria mitochondrial toxicity in vitro battery in vitro test battery ophthalmic eye drop direct contact product safety cytotoxicity potential molecular molecular biology refine reduce replace sensitivity and relevance sensitivity relevance rabbit ocular irritation test product development cytotoxicity models cytotoxicity alternative methods replacements for animal testing three r's beagle tiered testing tiered testing strategy replacements animal testing mechanistic toxicity cornea mitochondria dose response threshold Vision Science and Biology
44	Development of Sensitive In Vitro Assays to Assess the Ocular Toxicity Potential of Chemicals and Ophthalmic Products McCanna, David January 2009 (has links) The utilization of in vitro tests with a tiered testing strategy for detection of mild ocular irritants can reduce the use of animals for testing, provide mechanistic data on toxic effects, and reduce the uncertainty associated with dose selection for clinical trials. The first section of this thesis describes how in vitro methods can be used to improve the prediction of the toxicity of chemicals and ophthalmic products. The proper utilization of in vitro methods can accurately predict toxic threshold levels and reduce animal use in product development. Sections two, three and four describe the development of new sensitive in vitro methods for predicting ocular toxicity. Maintaining the barrier function of the cornea is critical for the prevention of the penetration of infections microorganisms and irritating chemicals into the eye. Chapter 2 describes the development of a method for assessing the effects of chemicals on tight junctions using a human corneal epithelial and canine kidney epithelial cell line. In Chapter 3 a method that uses a primary organ culture for assessing single instillation and multiple instillation toxic effects is described. The ScanTox system was shown to be an ideal system to monitor the toxic effects over time as multiple readings can be taken of treated bovine lenses using the nondestructive method of assessing for the lens optical quality. Confirmations of toxic effects were made with the utilization of the viability dye alamarBlue. Chapter 4 describes the development of sensitive in vitro assays for detecting ocular toxicity by measuring the effects of chemicals on the mitochondrial integrity of bovine cornea, bovine lens epithelium and corneal epithelial cells, using fluorescent dyes. The goal of this research was to develop an in vitro test battery that can be used to accurately predict the ocular toxicity of new chemicals and ophthalmic formulations. By comparing the toxicity seen in vivo animals and humans with the toxicity response in these new in vitro methods, it was demonstrated that these in vitro methods can be utilized in a tiered testing strategy in the development of new chemicals and ophthalmic formulations. in vitro Alternative Methods alamarBlue rhodamine tight junctions bovine lens viability toxicity mitochondria mitochondria integrity benzalkonium chloride sodium dodecyl sulphate sodium lauryl sulfate scanning electron microscopy Draize Draize maximal average scores zonula occludens cosmetic directive PETA humane society animal league ICCVAM ECVAM JaCVAM BCOP bovine cornea ocular irritants ocular irritation ocular toxicity human corneal epithelial cells vitro confocal confocal microscopy metabolic activity optical quality reactive oxygen species contact lens contact lens care solutions barrier function microbial keratitis mulitipurpose solutions tight junction cell damage claudin ZO-1 occludin MDCK Madin Madin-Darby canine kidney cells cornea human cornea human corneal epithelium epithelial cell line human corneal epithelial cell line sodium fluorescein sodium fluorescein permeability fluorescein permeability ocular surface cell monolayer Araki-Sasaki cell physiology risk assessment safety assessment ScanTox scanning laser lens epithelium corneal cells in vitro model ophthalmic formulations multiple instillation back vertex animal testing rabbit testing alternatives to animal testing cultured bovine lens toxicity of chemicals irritation irritants laser scanner organ culture delayed toxicity toxins hydrogen peroxide cornea toxicity cornea toxicity models prediction of human toxicity no observable adverse effect level lowest observable adverse effect level NOAEL LOAEL toxicity thresholds safety factors cornea uncertainty factors preservatives disinfectants ophthalmic products preclinical preclinical testing epithelial barrier drug penetration clinical confocal microscopy animal rights rabbit cornea human cornea human clinical effects toxic animal rights activist sensitive measures toxic effect toxicity threshold agar overlay agar diffusion agar overlay method agar diffusion method cytochrome cytochrome c apoptosis necrotic apoptotic necrosis caspase rhodamine 123 resazuran resorufin cell death cell viability metabolic dye microsomal microsomal enzymes cytotoxicity cytotoxic cytotoxic effect MTT XTT WST-1 plasma membrane mitochondrial mitochondrial morphology ocular toxicity potential ocular toxicity human corneal epithelial cell line confocal analysis corneal epithelium cell fluorescence alamarBlue assay rhodamine dye animal welfare toxic injury degraded mitochondria epithelial monolayer disinfectants membrane integrity eye toxicity eye viability dye toxicity in humans human toxicity effects on the mitochondria mitochondrial toxicity in vitro battery in vitro test battery ophthalmic eye drop direct contact product safety cytotoxicity potential molecular molecular biology refine reduce replace sensitivity and relevance sensitivity relevance rabbit ocular irritation test product development cytotoxicity models cytotoxicity alternative methods replacements for animal testing three r's beagle tiered testing tiered testing strategy replacements animal testing mechanistic toxicity cornea mitochondria dose response threshold Vision Science and Biology

Page generated in 0.1061 seconds