Realizamos um estudo num CAPSII da cidade de São Paulo. Tratou-se de uma pesquisa participativa, portanto uma pesquisa qualitativa que teve como referencial metodológico o Comunity-Based Participatory Research (CBPR). Tivemos a Reabilitação Psicossocial (RP) como referencial teórico, e tendo em vista a meta de emancipação e contratualização dos usuários do CAPS, realizamos uma pesquisa ação junto a um usuário e sua rede social. Mapeamos a rede social significativa deste usuário através do Mapa de Rede de Sluzki (2006), e iniciamos um trabalho de Acompanhamento Terapêutico (AT) junto ao usuário. Durante o processo compusemos as reuniões de Intervenção em Rede e ao fim construímos um segundo Mapa de Rede no intuito de avaliar se houve mudanças na composição da rede após as intervenções realizadas através desta pesquisa. A rede deste usuário era formada por pessoas do CAPS e de sua família que ao longo do processo apresentaram muitos recursos, era uma rede que inclusive já utilizara o AT e as reuniões de rede como forma de cuidado ao usuário e a própria rede. Vivenciamos nesse período, muitos momentos significativos e identificamos uma série de situações em que usuário e rede eram capazes de produção de sentido em seu cotidiano. Foi possível perceber a partilha de afeto entre o usuário e a rede, e inclusive entre os próprios membros da rede, e ao mesmo tempo havia troca de violência principalmente na relação entre o usuário e sua família. Era uma rede ciente dos preceitos da RP, mas ainda assim, com o agravamento da violência e se avaliava que o usuário estava pondo em risco a vida dele próprio e de seus familiares. A rede se viu impotente para lidar com essa questão e agiu afastando e internando o usuário. Durante o processo pudemos perceber que não somente o usuário, mas a família passara por um processo recente de perda de contratos sociais, especialmente quanto a trabalho e habitação. Ainda que apresente recursos é uma família que passou por um processo de exclusão do sistema de organização social, e o sentimento de impotência parece antes tratar desse processo do que da violência entre eles em si. Se apresenta tentador responsabilizar a família ou o serviço pelo processo vivido, mas parece se tratar de um processo mais complexo em que não se está claro qual é o papel de cada elemento. Através da convivência no serviço percebemos que a universidade e as pesquisas de pós graduação já compõem com o que se tem produzido nos CAPS, nesse sentido, mais do que eleger culpados, isso nos leva a supor ser necessário que nós, enquanto parte do problema, passemos a entender qual o papel que estamos desempenhando no processo, e talvez aí possamos fazer alguma diferença no ciclo que leva a violência, a impotência e a internação de uma pessoa / We conducted a study in a CAPSII at the city of São Paulo. This study is composed by a participatory research, using as a methodological referential the Community- Based Participatory Research (CBPR). The Psychosocial Rehabilitation (PR) was our theoretical referential, and based on the goal of emancipation of CAPS\'s users, we performed an action research with a user and his social network. We mapped the significant social network of this user with the Network Map of Sluzki (2006) and initiated a Therapeutical Accompaniment (TA) with him. During the process we did Network Interventions meetings and in the end we built a second Network Map, to evaluate if it changed after the interventions we performed during this research. This user\'s network was composed by people from CAPS e from his family, which during the process presented many resources, a network that already had used the TA and the network meetings to provide care for the user and for the network itself. We lived, during the entire period, several significant moments and identified that the user and the network were able to produce meaning in his daily life. We could observe the sharing of affection between user and network and also between the members of the network. At the same time an exchange of violence could also be observed, especially between the user and his family. Although the network was aware of the RP\'s precept, with the escalation of violence it was evaluated that the user was putting his and his family\'s life at risk. The network felt powerless to deal with this problem and acted moving away from the user and interning him. During the process we could notice that not the user alone, but the whole family have passed by a recent period of social contract loss, especially regarding work and habitation. Even though his family presents resources, it is a family that passed by a process of exclusion from the social organization system and the powerless feeling seems to be related to this process rather to the violence between them. It is tempting to charge family or the service by the lived process, but it seems a more complex process and the role of each element is not clear. We could notice that university and post-graduation research compose with what have been produced in the CAPS. Hence, more than electing the guilty ones, this lead us to suppose that is necessary that us, as part of the problem, start to understand what is our role in the process, then we perhaps might make any difference in the cycle that leads to violence, impotence and people\'s internment

Thesis is focused on special education - speech therapy and summarizes current findings about etiology, classification and symptomatology of aphasia, it also involves different approaches to the diagnosis and therapy. Thesis contains therapeutical materials, the use of which in practice is illustrated by case studies of five individuals with aphasia.

<p align="justify">The production of reactive oxygen species is strictly kept under control in the Human body. However, several conditions are characterized by the over-production or the uncontrolled production of these species, promoting damage to the host tissue. Among oxygen species producer, the myeloperoxidase/hydrogen peroxide/chloride system is a key element. This the consequence of the large quantity of myeloperoxidase found in neutrophils and that can be released rapidly during an inflammatory process. Moreover, hypochlorous acid, synthesized by this system, is a powerful oxidant.</p><p><p align="justify">We have studied the impact of non-steroidal anti-inflammatory drugs (oxicams, nimesulid and flufenamic acid) on three reactive oxygen species, namely, hydroxyl radical, hydrogen peroxide and hypochlorous acid. The first results showed the weak antioxidant properties of these molecules and the necessity to focus on the myeloperoxidase/hydrogen peroxide/chloride system. During the study of the myeloperoxidase inhibition, it appeared that flufenamic acid was an efficient inhibitor that modulated the hypochlorous acid production and was directly oxidized by the enzyme.</p><p><p align="justify">Due to the efficacy of flufenamic acid, this molecule was tested in a model of myeloperoxidase-dependent low-density lipoprotein (LDL) oxidation and compared to thiol-containing molecules like N-AcetylCystein and its lysinate salt, glutathione and captopril. The results showed that flufenamic acid lost part of its inhibiting effect while thiol-containing molecules demonstrated an interesting inhibiting activity in this model. A potential explanation could be the ability of myeloperoxidase to bind lipoproteins, masking the entry of its catalytic pocket. In these conditions, the inhibitor size becomes a key parameter in the inhibition of the MPO-dependent low-density lipoprotein oxidation and N-AcetylCystein appears as a powerful inhibitor in this context. These results render N-AcetylCystein an excellent candidate for studies that focus on the reduction of cardiovascular pathology risk.</p><p><p><br><p><p><p align="justify">Le corps humain est le siège constant de la synthèse d’espèces oxygénées réactives dont la production contrôlée est indispensable au bon fonctionnement de l’organisme. Cependant dans de nombreuses pathologies, il arrive qu’une production exagérée et/ou incontrôlée de ces espèces aboutisse à des dégâts oxydatifs. Parmi les mécanismes de production d’espèces oxydantes, le système myéloperoxydase / peroxyde d’hydrogène / chlorure détient une place importante. Ceci est notamment la conséquence de la grande quantité de MPO présente dans les neutrophiles, pouvant être libérée très rapidement lors de l’inflammation. De plus l’acide l’hypochloreux synthétisé par ce système est un très bon oxydant.</p><p><p align="justify">Nous avons étudié l’impact des anti-inflammatoires non-stéroïdiens (oxicams, nimésulide et acide flufénamique) sur trois espèces oxygénées réactives :le radical hydroxyle, le peroxyde d’hydrogène et l’acide hypochloreux. Les premiers résultats montrent le faible pouvoir anti-oxydant des molécules testées et la nécessité de concentrer notre recherche sur le système myéloperoxydase / peroxyde d’hydrogène / chlorure, responsable de la synthèse de l’acide hypochloreux. Lors de l’étude de l’inhibition de ce système, il est ressorti que l’acide flufénamique est un bon inhibiteur de la myéloperoxydase car il inhibe la synthèse de l’acide hypochloreux en étant directement oxydé par l’enzyme.</p><p><p align="justify">En raison de l’efficacité de l’acide flufénamique, cette molécule a été testée dans un modèle d’oxydation des lipoprotéines de basse densité (LDL) par le système myéloperoxydase / peroxyde d’hydrogène / chlorure en comparaison avec des thiols tels que la N-acétylcystéine et son sel de lysine, le glutathion et le captopril. Les résultats montrent une perte importante du pouvoir d’inhibition de l’acide flufénamique dans ce modèle alors que les thiols et la N-acétylcystéine en particulier, présentent une efficacité non négligeable. Ce phénomène pourrait être attribué à la capacité de la myéloperoxydase de se fixer sur les lipoprotéines, ce qui pourrait masquer l’entrée du site catalytique. Dans ces conditions, la taille de la molécule devient un facteur crucial dans l’inhibition de l’oxydation des lipoprotéines de basse densité et la N-acétylcystéine apparaît dès lors comme un inhibiteur puissant dont les résultats en font un excellent candidat dans des études d’intervention visant la diminution du risque de pathologies cardiovasculaires chez certains patients.</p> / Doctorat en Sciences biomédicales et pharmaceutiques / info:eu-repo/semantics/nonPublished

[pt] Trauma e regressão são dois conceitos que sempre suscitaram debates e mesmo controvérsias em Psicanálise. No decorrer da presente tese, procuramos analisar o desenvolvimento de ambos nas teorizações de Freud e de alguns dos principais teóricos das relações objetais precoces, dentre os quais destacam-se Donald Winnicott e Michael Balint, que, na esteira das mudanças operadas na teoria e na técnica analíticas por Sàndor Ferenczi, ampliaram de forma original o escopo teórico em torno de determinados fenômenos clínicos que implicam em formas singulares de sofrimento subjetivo. Neste sentido, buscamos articular nossa reflexão com alguns outros conceitos fundamentais propostos por esses autores; mais especificamente, os conceitos de amor primário e falha básica em Balint, e os de holding e fenômenos transicionais em Winnicott. A partir daí, sustentamos que o pensamento teórico-clínico baseado no modelo relacional tem possibilitado uma melhor apreensão dos processos determinantes da constituição psíquica e das diferentes formas de subjetivação e elaboração do trauma, nas quais a compreensão da situação analítica como campo comum inconsciente passa a ser relevante para o processo terapêutico. / [en] Trauma and regression are concepts that have always raised some debate and controversy in Psychoanalysis. Throughout the present thesis, the development of both will be analyzed in Freud s theories and also in some of the main authors on the early object relations, among which Donald Winnicott and Michael Balint stand out for improving the changes made in the analysis theory and techniques developed by Sàndor Ferenczi. The two enlarged in an inventive way the theoretical scope around certain clinical phenomena that bring about unique subject suffering. In this line of thought, this paper aims to associate some reflection to other fundamental concepts proposed by these authors; more specifically, the concepts of primary love and of basic fault in Balint, and those of holding and transitional phenomena in Winnicott. On this ground, it can be concluded that the clinical-theoretical thinking based on the relational model has enabled a better apprehension of the processes which are essential in the psychic constitution and in the various ways to take power over and elaborate on trauma, in which understanding of the analytical situation, as an unconscious common ground turns out to be relevant for the therapeutical process.

Des nanoparticules d’oxydes de fer superparamagnétiques (SPIONs) PEGylées ont servi de plateforme pour la formulation de nanovecteurs théragnostiques pour la délivrance d’un agent anticancéreux, la doxorubicine (DOX). Le chargement de la DOX sur les nanovecteurs à l’aide d’un complexe avec l’ion fer (II) a été optimisé. Ce complexe se dissocie en milieu acide, typique des compartiments intracellulaires. La spectroscopie Raman exaltée de surface (SERS) a confirmé que les nanovecteurs libèrent la DOX sous forme non complexée. La cytotoxicité in vitro induite par la libération de la DOX a été évaluée sur différentes lignées cellulaires de cancer du sein, et comparée à celle de la DOX en solution. Les voies d’internalisation des nanovecteurs ont été explorées en microscopie électronique en transmission (MET), et le devenir intracellulaire de la DOX a été suivi en imagerie confocale multispectrale (ICMS). Enfin, un protocole thérapeutique in vivo chez la souris tumorisée a permis d’évaluer la capacité de la nanoformulation à limiter la croissance tumorale, la possibilité d’un ciblage magnétique, et la réduction des effets secondaires induits par la DOX. / PEGylated superparamagnetic iron oxide nanoparticles (SPIONs) were used as a platform to build theranostic nanovectors for the delivery of an anticancer drug, doxorubicin (DOX). The DOX loading on nanocarriers via a DOX-iron (II) complex was optimized. The complex dissociates at low pH, typical of intracellular compartments. Surface enhanced Raman scattering (SERS) confirmed that the nanovectors released DOX under free form. In vitro cytotoxicity due to DOX loaded on nanocarriers was performed on different breast cancer cells, and compared to that of DOX in solution. Internalization pathways of nanovectors were explored with transmission electron microscopy (TEM), and intracellular fate of DOX was monitored by confocal spectral imaging (CSI). To finish, a therapeutical protocol was performed on tumorized mice, in order to evaluate the efficacy of the nanoformulation on tumor reduction, the possibility of magnetic targeting, and the decrease of side effects induced by DOX.

Made available in DSpace on 2016-04-28T18:23:28Z (GMT). No. of bitstreams: 1 Claudia L Passalacqua.pdf: 542023 bytes, checksum: d12f5515154be2bd94e524c3bbaa52b3 (MD5) Previous issue date: 2007-05-04 / This paper investigates a writing tool, namely Self-Portrait, whose aim is to collect data on an individual´s psychic expression. It comprises a 35 question questionnaire, made up of open-ended directed and self directed questions. The order of the answers is random, and some questions may be answered many times while others may never be answered. This writing tool was used in a group of psychologically disturbed women, who had been referred to a state health center in the outskirts of São Paulo city. Most women belong to the low and low-middle classes, with very few years of schooling, but, in general, with working experience, in the 30-60 age bracket. They were referred to the state health center by psychiatrists and psychologists, due to chief complaints such as depression, stress, etc. The group was coordinated by the research-psychologist and by an occupational therapist. Initially, the treatment aimed to engage the group in manual tasks and provide them with some space in which they could air their problems. On presenting the questionnaire to the women, the research-psychologist read them the iinstructions, their questions, and explained the procedures as well the terms of agreement. The questionnaire was kept in the health center and apart from the subjects and the therapist, nobody else had access to them. Due to all the conditions of public service assiduity, punctuality, follow-up sessions, among others the use of the self-portrait was not constant in all the sessions and wasn´t equally used by all the women. Since the activities were decided on by the group and took place in the inicial phases of the group´s functioning, it was hard to maintain group cohesion, as some women answered the questionnaires in each session while others took longer to write. These differences were inevitable once all the women shared a common physical space. The self-potrait questions aimed at categorizing those women´s realities: routine, family and professional life, emotional, psychological and existencial aspects and world knowledge. Moreover, the written account of their life experiences served as an oulet for the free expresson of their reality The therapeutical aim of the self-portrait was to investigate the efficiency of writing as a mechanism to surface the underlying phychic information, despite the fact that this written account was produced by women of varying literacy levels. Writing differs from speech in that writing can be crystalized in time, once it can be registered permanently. Besides, writing entails a distinctive connection between conscious and uncounscious contents. It leads the individual into an introspective journey, allowing for the re-enactment of past experiences. By means of this exercise, processes and memories are brought to the consciosness mind and may be modified when experienced again. This study falls into the category of case study, once it focus on aspect´s of a specific woman´s life: someone who, upon joining the group, felt incredbly miserable and was, from the very begining, given special treatment by the research-psychologist. The same rules which applied for the self-portrait within the group were used in private consultations. Semantic networks, formed by words that were repeated along the text, were used for the analysis of the written accounts, following Jung's Model of Typology / Este trabalho investiga um instrumento de escrita, intitulado Auto-Retrato, destinado a coletar dados sobre a expressão psíquica do indivíduo. Trata-se de um questionário de trinta e cinco questões, abertas, dirigidas ou semi-dirigidas, no qual a ordem das respostas é livre, assim como o fato de que algumas questões podem vir a ser respondidas inúmeras vezes e outras, nunca serem respondidas. O instrumento foi utilizado num grupo de mulheres, encaminhadas, pela saúde mental, a um posto de saúde da periferia de São Paulo. As mulheres pertenciam a classes sócio-econômico-culturais baixa e média baixa, em sua maior parte, com poucos anos de escolaridade, mas, no, geral, com experiência de trabalho, na faixa etária de 30 a 60 anos. Chegaram ao posto de saúde via encaminhamentos de psiquiatras e psicólogos, com queixas de depressão, estresse, entre outras. O grupo era coordenado pela psicóloga-pesquisadora e por uma terapeuta ocupacional. Inicialmente, seu objetivo era realizar atividades manuais e paralelamente a elas criar um espaço para a fala e escuta das mulheres entre si e pelas terapeutas. Ao apresentar o questionário às mulheres, a psicóloga-pesquisadora leu a elas suas instruções, suas questões, explicou-lhes as formas de utilização, juntamente com o Termo de Consentimento Livre e Esclarecido.O questionário era mantido no posto de saúde e apenas cada mulher e as terapeutas tinham acesso a ele. Devido a todas as condições que envolvem um atendimento público - assiduidade, pontualidade, continuidade do atendimento, entre outras - o emprego do Auto-Retrato não ocorreu de modo constante em todas as sessões e nem foi igualmente usado por todas as mulheres. Como as atividades eram decididas pelo grupo e no início de seu funcionamento, foi difícil manter a unidade do grupo, com algumas mulheres respondendo-o em todas as sessões, até por se tratar de um espaço físico comum. As questões do Auto-Retrato tinham como objetivo caracterizar a realidade dessas mulheres: vivências cotidianas, vida familiar e profissional, aspectos emocionais, psicológicos e existenciais, conhecimento de mundo e visava ser um continente para a expressão dessa realidade por meio da escrita. .. O emprego do Auto-Retrato teve como objetivo psicoterapêutico investigar a eficácia da escrita para a manifestação de conteúdos psíquicos subjacentes, não importando a variável de a escrita ser realizada por mulheres com diferentes graus de letramento. A escrita tem natureza diferente da fala, fixando-se no tempo, sendo registrada de uma forma permanente, e evocando um compromisso diferente com conteúdos conscientes e inconscientes. Inicia um processo de interiorização no indivíduo, possibilitando uma volta aos conteúdos veiculados. Por meio de seu exercício, processos e memórias são trazidos à consciência e modificados quando revividos. Este trabalho se constituirá em um estudo de caso, na medida em que focará o Auto-Retrato de uma mulher em específico, quem, por ter chegado ao grupo sentindo-se especialmente mal, foi, desde o início, atendida paralelamente de modo individual pela psicóloga-pesquisadora. As mesmas regras estabelecidas para o uso do Auto-Retrato no grupo, foram usadas para sua aplicação na terapia individual. Para a análise do texto escrito do Auto-Retrato os modelos teóricos empregados foram as redes semânticas, formadas pelas palavras que se repetiam no texto escrito, e o referencial teórico de Jung, principalmente, no que se refere aos tipos psicológicos por ele propostos

Os antimaláricos, cloroquina e hidroxicloroquina, têm sido usados há décadas com bons resultados terapêuticos para o tratamento do lupus eritematoso e são considerados medicações seguras, muito embora, haja preocupação em relação à retinotoxicidade, notadamente com a cloroquina. O objetivo deste trabalho foi avaliar a ocorrência dos efeitos adversos desencadeados pelo tratamento com 250mg/d de difosfato de cloroquina em doentes com lupus eritematoso, dando ênfase à retinotoxicidade. Foram estudados 350 doentes e reavaliados seus respectivos prontuários, que datavam de 1980 a 2003. Os doentes foram acompanhados no ambulatório de colagenoses da Divisão de Dermatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo. A ocorrência dos efeitos adversos foi de 35,7%, sendo que 17,4% decorreram de alterações oculares. Em 12% dos doentes ocorreu pigmentação retiniana sugestiva de retinopatia antimalárica, em 3,1% depósitos corneanos e, em 2,3%, sintomas visuais agudos. Em 10% dos doentes houve alterações gastrointestinais: epigastralgia (6%), náuseas e vômitos (3,7%) e diarréia (0,3%). Alterações dermatológicas ocorreram em 3,4% dos doentes: rash cutâneo no início do tratamento (2%), exacerbação de quadro de psoríase pré-existente (0,3%) e pigmentação cutânea (1,1%). Ocorreram ainda cefaléia (2,9%), alterações neuromusculares (1,7%) com quadro gripal símile no início do tratamento (1,1%), neuropatia sensitiva (0,3%) e miopatia compatível com miastenia (0,3%) e, sintomas neuropsiquiátricos (0,3%). A droga foi suspensa devido aos efeitos adversos em 22,9% dos doentes, principalmente, em decorrência de alterações oculares, gastrointestinais e dermatológicas. A reavaliação oftalmológica de 12% dos doentes com pigmentação retiniana, confirmou a retinopatia antimalárica em apenas 2,6%, o que demonstrou uma tendência à valorização de alterações retinianas inespecíficas, discretas e unilaterais, com indicação desnecessária da suspensão da droga em 9,4% dos doentes. Não ocorreram casos de retinopatia antimalárica avançada com lesão do tipo bull-eye. Não houve associação estatisticamente significativa entre a ocorrência de efeitos adversos e alterações retinianas com dose diária de difosfato de cloroquina por quilo de peso e com o tipo clínico do lupus eritematoso. As alterações retinianas foram estatisticamente significativas nos doentes acima de cinqüenta anos quando comparado ao grupo abaixo dos cinqüenta anos, possivelmente pela dificuldade em diferenciar as alterações iniciais da retinopatia antimlárica daquelas decorrentes da degeneração macular senil. O controle oftalmológico foi realizado em intervalo médio de 10,5 meses, demonstrando que o controle anual foi eficaz para o acompanhamento dos doentes. Nove doentes foram expostas durante o primeiro trimestre gestacional, não ocorrendo casos de mal formação fetal / Antimalarial agents, chloroquine and hydroxichloroquine, have been used for decades leading to good therapeutic outcomes at treatment approach for lupus erythematosus and are considered safe medication; however, the main concern is retina toxicity, especially with chloroquine. The purpose of the present study was to conduct analysis of the occurrence of adverse effects, triggered by use of 250 mg/d of chloroquine diphosphate at treatment for lupus erythematosus, especially retina toxicity. We analyzed 350 patients and reviewed their medical charts, from 1980 to 2003. The patients were followed up by the outpatient unit of collagenosis, Division of Dermatology, Hospital das Clinicas, Medical School, University of São Paulo. The occurrence of adverse effects was 35.7%, and eye affections were detected in 17.4% of patients. Impairment of retina pigmentation suggestive of antimalarial retinopathy occurred in 12%, cornea deposits in 3,1%, and acute visual symptoms in 2.3%. Gastrointestinal affections were detected in 10% of patients: epigastralgia (6%), nausea and vomiting (3.7%) and diarrhea (0.3%). Dermatological affections occurred in 3.4% of patients: skin rash in the beginning of treatment (2%), exacerbation of preexisting psoriasis (0.3%) and skin pigmentation (1.1%). We also detected headache (2.9%), neuromuscular disorders (1.7%) with flu-like episode at the beginning of treatment (1,1%), sensitive neuropathy (0,3%) and myopathy compatible with myasthenia (0.3%) and neuropsychiatric symptoms (0.3%). Discontinuation of drugs owing to side effects occurred in 22.9% of the patients, being that the main affections were eye, gastrointestinal and dermatological occurrences. Ophthalmologic reevaluation of retina pigmentation affections occurred in 12% of the patients, but we confirmed antimalarial retinopathy only in 2.6%, detecting a tendency to value nonspecific, discreet and unilateral affections, which generated unnecessary recommendations for discontinuation of drug in 9.4% of the patients. There were no cases of advanced retinopathy with bull-eye type lesion. There was no statistically significant association between occurrence of adverse effects and retina affections with daily dose per kg of chloroquine diphosphate and the differents types of lupus erythematosus. In patients over the age of 50, there was statistically significant increase in number of retina affections when compared to the group aged below 50 years, possibly owing to difficulty to differentiate between initial affections in antimalarial retinopathy from those resultant from senile macular degeneration. Ophthalmologic control was conducted on average after 10.5 months, showing that annual follow-up was effective to keep track of patients. Nine of the patients were exposed during the first gestational trimester and there were no cases of fetal malformations

Os problemas decorrentes do uso de álcool trazem impactos relevantes para o campo da saúde pública e levam ao desenvolvimento de políticas e propostas de tratamento baseadas em perspectivas e abordagens teórico-práticas que apresentam marcantes diferenças entre si, o que resulta na pluralidade de ofertas terapêuticas atuais. Tratase de questão complexa que envolve fatores de diversas ordens: socioculturais, econômicos, políticos, sócio-familiares e individuais. Tal complexidade deve ser considerada na construção das práticas de saúde e na compreensão dos processos de busca, escolha e adesão as propostas de tratamento, como interativos, relacionais e dotados de significados singulares. O presente estudo visou conhecer os itinerários terapêuticos de sujeitos com problemáticas decorrentes do uso prejudicial de álcool em um Centro de Atenção Psicossocial para usuários de álcool e outras drogas CAPSad. A pesquisa, de caráter qualitativo, foi orientada pela perspectiva etnometodológica, e empregou os procedimentos metodológicos de revisão bibliográfica, pesquisa documental, entrevistas semi-estruturadas, grupo focal, observação participante e construção de diário de campo. O trabalho de campo foi realizado no CAPSad Travessia, situado no município de Santana de Parnaíba/SP, no período de janeiro a março de 2009. Os resultados mostraram que os itinerários terapêuticos dos participantes foram compostos por um conjunto de ações sucessivas e muitas vezes sobrepostas. Os sujeitos tendem a recorrer simultaneamente a diversos lugares de tratamento e cuidado e chegam ao serviço de saúde sem a formulação clara do problema e nem tampouco com conhecimento sobre a proposta do serviço. Tal percurso não se configura como resultado de escolhas racionais prévias, mas da experiência construída no processo, que dota de significados as vivências e problemáticas relacionadas ao uso de álcool e a própria necessidade de busca de ajuda e enfrentamento do problema. Nesse processo, nota-se a importância das redes sócio relacionais, no contexto das quais são compartilhados os significados atribuídos às experiências e a orientação e sustentação dos processos de busca de ajuda. Concluímos que a preocupação em conhecer os saberes e práticas dos sujeitos na construção de seus itinerários terapêuticos deve compor as práticas de cuidado, desenvolvidas pelos profissionais nos serviços de saúde, comprometidas com o fortalecimento dos sujeitos individuais e coletivos, com a construção de direitos e cidadania e com a produção de saúde e de vida / Problems in consequence of the use of alcohol bring on relevant impacts to public health field and lead to the development of policies and treatment proposals based on perspectives and theoretical-practical approaches that present marked differences among them, resulting on the plurality of current therapeutic offers. This is a complex question that involves factors in several orders: sociocultural, economics, politics, socio-familiars and individuals. This complexity should be considered in the construction of health practices and understanding of the processes of search, choice and adherence to the treatment proposals, as interactive, relational and endowed of singular meanings. This study aimed to know the therapeutic itineraries of individuals with problems in consequence of harmful use of alcohol in a Psychosocial Care Center for users of alcohol and others substances CAPSad. The research used qualitative methods and was oriented by the ethnomethodological perspective. It employed the methodological procedures of bibliographical review, documental research, semi-structured interviews, focus group, participant observation and construction of field diary. The fieldwork was conducted in CAPSad Travessia, located in the city of Santana de Parnaíba/SP, from January to March of 2009. The results showed that the therapeutic itineraries of the participants were composed of a set of successive and often overlapping actions. The individuals tend to appeal simultaneously to several places of treatment and care and arrive to the health service without a clear formulation of the problem and neither informed about the proposal of the service. This pathway do not configure itself as a result of previous rational choices, but as the experience built during the process, which attributes meanings to the experiences and problems related to alcohol use and to the own necessity of help search and confrontation of the problem. In this process, it is possible to note the importance of social relational networks, in the context of which the meanings attributed to the experiences and the orientation and sustentation of process of help searching are shared. We conclude that the preoccupation in knowing the knowledge and practices of the individuals on the construction of their therapeutic itineraries must compose the care practices, developed by professionals in the health services, committed with the strengthening of individual and collective subjects, with the construction of rights and citizenship and with the production of health and life

Os antimaláricos, cloroquina e hidroxicloroquina, têm sido usados há décadas com bons resultados terapêuticos para o tratamento do lupus eritematoso e são considerados medicações seguras, muito embora, haja preocupação em relação à retinotoxicidade, notadamente com a cloroquina. O objetivo deste trabalho foi avaliar a ocorrência dos efeitos adversos desencadeados pelo tratamento com 250mg/d de difosfato de cloroquina em doentes com lupus eritematoso, dando ênfase à retinotoxicidade. Foram estudados 350 doentes e reavaliados seus respectivos prontuários, que datavam de 1980 a 2003. Os doentes foram acompanhados no ambulatório de colagenoses da Divisão de Dermatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo. A ocorrência dos efeitos adversos foi de 35,7%, sendo que 17,4% decorreram de alterações oculares. Em 12% dos doentes ocorreu pigmentação retiniana sugestiva de retinopatia antimalárica, em 3,1% depósitos corneanos e, em 2,3%, sintomas visuais agudos. Em 10% dos doentes houve alterações gastrointestinais: epigastralgia (6%), náuseas e vômitos (3,7%) e diarréia (0,3%). Alterações dermatológicas ocorreram em 3,4% dos doentes: rash cutâneo no início do tratamento (2%), exacerbação de quadro de psoríase pré-existente (0,3%) e pigmentação cutânea (1,1%). Ocorreram ainda cefaléia (2,9%), alterações neuromusculares (1,7%) com quadro gripal símile no início do tratamento (1,1%), neuropatia sensitiva (0,3%) e miopatia compatível com miastenia (0,3%) e, sintomas neuropsiquiátricos (0,3%). A droga foi suspensa devido aos efeitos adversos em 22,9% dos doentes, principalmente, em decorrência de alterações oculares, gastrointestinais e dermatológicas. A reavaliação oftalmológica de 12% dos doentes com pigmentação retiniana, confirmou a retinopatia antimalárica em apenas 2,6%, o que demonstrou uma tendência à valorização de alterações retinianas inespecíficas, discretas e unilaterais, com indicação desnecessária da suspensão da droga em 9,4% dos doentes. Não ocorreram casos de retinopatia antimalárica avançada com lesão do tipo bull-eye. Não houve associação estatisticamente significativa entre a ocorrência de efeitos adversos e alterações retinianas com dose diária de difosfato de cloroquina por quilo de peso e com o tipo clínico do lupus eritematoso. As alterações retinianas foram estatisticamente significativas nos doentes acima de cinqüenta anos quando comparado ao grupo abaixo dos cinqüenta anos, possivelmente pela dificuldade em diferenciar as alterações iniciais da retinopatia antimlárica daquelas decorrentes da degeneração macular senil. O controle oftalmológico foi realizado em intervalo médio de 10,5 meses, demonstrando que o controle anual foi eficaz para o acompanhamento dos doentes. Nove doentes foram expostas durante o primeiro trimestre gestacional, não ocorrendo casos de mal formação fetal / Antimalarial agents, chloroquine and hydroxichloroquine, have been used for decades leading to good therapeutic outcomes at treatment approach for lupus erythematosus and are considered safe medication; however, the main concern is retina toxicity, especially with chloroquine. The purpose of the present study was to conduct analysis of the occurrence of adverse effects, triggered by use of 250 mg/d of chloroquine diphosphate at treatment for lupus erythematosus, especially retina toxicity. We analyzed 350 patients and reviewed their medical charts, from 1980 to 2003. The patients were followed up by the outpatient unit of collagenosis, Division of Dermatology, Hospital das Clinicas, Medical School, University of São Paulo. The occurrence of adverse effects was 35.7%, and eye affections were detected in 17.4% of patients. Impairment of retina pigmentation suggestive of antimalarial retinopathy occurred in 12%, cornea deposits in 3,1%, and acute visual symptoms in 2.3%. Gastrointestinal affections were detected in 10% of patients: epigastralgia (6%), nausea and vomiting (3.7%) and diarrhea (0.3%). Dermatological affections occurred in 3.4% of patients: skin rash in the beginning of treatment (2%), exacerbation of preexisting psoriasis (0.3%) and skin pigmentation (1.1%). We also detected headache (2.9%), neuromuscular disorders (1.7%) with flu-like episode at the beginning of treatment (1,1%), sensitive neuropathy (0,3%) and myopathy compatible with myasthenia (0.3%) and neuropsychiatric symptoms (0.3%). Discontinuation of drugs owing to side effects occurred in 22.9% of the patients, being that the main affections were eye, gastrointestinal and dermatological occurrences. Ophthalmologic reevaluation of retina pigmentation affections occurred in 12% of the patients, but we confirmed antimalarial retinopathy only in 2.6%, detecting a tendency to value nonspecific, discreet and unilateral affections, which generated unnecessary recommendations for discontinuation of drug in 9.4% of the patients. There were no cases of advanced retinopathy with bull-eye type lesion. There was no statistically significant association between occurrence of adverse effects and retina affections with daily dose per kg of chloroquine diphosphate and the differents types of lupus erythematosus. In patients over the age of 50, there was statistically significant increase in number of retina affections when compared to the group aged below 50 years, possibly owing to difficulty to differentiate between initial affections in antimalarial retinopathy from those resultant from senile macular degeneration. Ophthalmologic control was conducted on average after 10.5 months, showing that annual follow-up was effective to keep track of patients. Nine of the patients were exposed during the first gestational trimester and there were no cases of fetal malformations

Les politiques de lutte contre les maladies plus généralement et celles relatives au paludisme singulièrement, mises en œuvre depuis 1948, ont connu des fortunes diverses dans leur application à l'échelle locale. L'exemple de la Côte d'Ivoire que cette recherche a mis en lumière en est la parfaite illustration. Ainsi, de la politique «d'éradication du paludisme» qui couvre la période 1955-1970, à laquelle succède celle du contrôle du paludisme depuis cette date, les directives de lutte, qui accompagnent les grands programmes de santé de l'institution internationale, ont été diversement appliquées, du moins en ce qui concerne le paludisme. Les raisons de ce décalage entre les indications normatives et les pratiques thérapeutiques sont à la fois exogènes et endogènes. Cette étude illustre ainsi les contradictions entre les politiques de santé décidées en amont, et leur application, en aval. Elle permet de saisir aussi, le rôle central de l'OMS dans la gouvernance de la santé mondiale. Mais, elle n'occulte pas pour autant les énormes difficultés encore pendantes des systèmes de santé des pays en voie de développement comme la Côte d'Ivoire, malgré tous les efforts entrepris par l'OMS pour y remédier. / The policies to fight diseases in general and malaria in particular since 1948 have met different forms in their implementation on a local scale. The example of the Côte d'Ivoire that this study has brought into light perfectly illustrates that point. From an "eradication of malaria" policy that ranges from 1955 to 1970 to a control of malaria since then, the fighting directives, which go along with the main health programs of international institution, have been variously implemented, at least as far as malaria is concerned. The reasons that account for this discrepancy between normative indications and therapeutical practices are both exogenous and endogenous. This study thus illustrates the contradictions between health policies decided upstream and their implementation downstream. It also helps to understand the major role of the World Health Organisation in its govemance in world health. But it does not ignore the huge and still remaining difficulties of health systems of developing countries such as the Côte d'Ivoire in spite of all the efforts undertaken by the WHO to deal with them.