In the last 50 years, a considerable amount of research workhas been completed in the mathematical system theory and theoryof control. Implementation of the results from this researchinto practice has drastically decreased the production costs.Most production processes are highly automated, and the use ofrobots in industry is growing. As far as office, or businessprocesses are concerned, the situation is quite different.Though the office workers and sales personnel have obtainedmuch help from the modern computers, the office and salesprocesses are far behind the production processes on the levelof automation. The computers are used in the office mainly tohelp in performing various activities, e.g., to write a letter,to print an invoice, to complete a transaction, etc. Thecontrol of the business processes in the office remains, to alarge extent, manual. There is a lot to gain if the controlover business processes could be automated, at leastpartially. The material presented in this thesis is aimed to supportthe following hypothesis: "The ideas worked out in the Mathematical system theory formodeling and controlling physical processes can be successfullyused for modeling and controlling business processes." Oneof the main ideas of mathematical system theory is to considera process as a set of valid trajectories in a state space, andthis idea is the keystone for the thesis. The thesis startswith reformulating the state-oriented approach for the domainof business processes to show what kind of sate space can beused in this domain. First, the approach is introducedinformally by means of an example. Next, a possibleformalization adjusted to the properties of business processesis discussed. Then, experimental evidences that the methodsuggested in the thesis can be used in practice are presented.The suggested method is also compared with other methods ofbusiness process modeling to find out the areas where it hasadvantages over the other methods. In the conclusion, theresults are summarized, and plansfor the future are drawn. Most of the material included in the thesis has beenpublished and presented at international conferences. Thecontribution of this thesis consists in organizing the materialin support of the main hypothesis.

Desde los inicios de la era de la información la reutilización ha supuesto una práctica habitual para el desarrollo de aplicaciones software. Actualmente, la reutilización de software continúa siendo una aspecto esencial en los sistemas de información actuales por el uso de componentes software, vistos como colecciones de código reutilizables que facilitan el desarrollo de aplicaciones software.La aparición de los servicios web ha proporcionado un modelo diferente para el desarrollo de aplicaciones, ofreciendo la capacidad de acceder a servicios heterogéneos de forma unificada e interoperable a través de Internet. Nuevas aplicaciones web son creadas componiendo o combinando servicios web heterogéneos. Desafortunadamente, los desarrollos actuales prestan escasa atención a la reutilización de composiciones de servicios, como mecanismo para facilitar y reducir la complejidad existente a medida que crece el número de servicios web involucrados en una composición.La contribución más importante de esta tesis ha consistido en aportar una aproximación para la composición de servicios web con el fin de facilitar el desarrollo de aplicaciones web basadas en servicios flexibles y reutilizables. Por una parte, la aproximación propuesta introduce el concepto de componente integrado, visto como una unidad básica reutilizable, que integra las características más relevantes sobre reutilización presente en los sistemas basados en componentes software y en el área de los workflows. Por otra parte, esta aproximación describe una metodología de composición para la creación, composición, reutilización de componentes integrados para transformarlos finalmente en procesos ejecutables.

No description available.

The report analyses if some common problems can be avoided by using modern technology. As a reference system “Fartygsrapporteringssystemet” is used. It is an n-tier web application built with modern technology at time, 2003-2004. The aim is to examine whether ASP.Net MVC, Windows Communication Foundation, Workflow Foundation and SQL Server 2005 Service Broker can be used to create an n-tier web application which also communicate with other systems and facilitate automated testing. The report describes the construction of a prototype in which the presentation layer uses ASP.Net MVC to separate presentation and business logic. Communication with the business layer is done through the Windows Communication Foundation. Hard coded processes are broken out and dealt with by Workflow Foundation. Asynchronous communication with other systems is done by using Microsoft SQL Server 2005 Service Broker. The results of the analysis is that these techniques can be used to create a n-tier web application, but that ASP.Net MVC, which at present only available in a preview release, is not sufficiently developed yet.

<p>The aims of this dissertation are to investigate the use and usefulness of patterns in Information Systems Engineering and to identify future areas of research. In order to do this there is a need to survey different types of patterns and find a common concept of patterns. A pattern is based on experience found in the real world. A text or a model or a combination of the both can describe the pattern. A pattern is typically described in terms of context, forces, problem, and solution. These can be explicitly expressed or implicitly found in the description of the pattern.</p><p>The types of patterns dealt with are: object-oriented patterns; design patterns, analysis patterns; data model patterns; domain patterns; business patterns; workflow patterns and the deontic pattern. The different types of patterns are presented using the authors' own terminology.</p><p>The patterns described in the survey are classified with respect to different aspects. The intention of this analysis is to form a taxonomy for patterns and to bring order into the vast amount of patterns. This is an important step in order to find out how patterns are used and can be used in Information Systems Engineering. The aspects used in the classification are: level of abstraction; text or model emphasis; product or process emphasis; life cycle stage usage and combinations of these aspects.</p><p>Finally an outline for future areas of research is presented. The areas that have been considered of interest are: patterns and Information Systems Engineering methods; patterns and tools (tool support for patterns); patterns as a pedagogical aid; the extraction and documentation of patterns and patterns and novel applications of information technology. Each future area of research is sketched out.</p>

<p>In the last 50 years, a considerable amount of research workhas been completed in the mathematical system theory and theoryof control. Implementation of the results from this researchinto practice has drastically decreased the production costs.Most production processes are highly automated, and the use ofrobots in industry is growing. As far as office, or businessprocesses are concerned, the situation is quite different.Though the office workers and sales personnel have obtainedmuch help from the modern computers, the office and salesprocesses are far behind the production processes on the levelof automation. The computers are used in the office mainly tohelp in performing various activities, e.g., to write a letter,to print an invoice, to complete a transaction, etc. Thecontrol of the business processes in the office remains, to alarge extent, manual. There is a lot to gain if the controlover business processes could be automated, at leastpartially.</p><p>The material presented in this thesis is aimed to supportthe following hypothesis: "<i>The ideas worked out in the Mathematical system theory formodeling and controlling physical processes can be successfullyused for modeling and controlling business processes</i>." Oneof the main ideas of mathematical system theory is to considera process as a set of valid trajectories in a state space, andthis idea is the keystone for the thesis. The thesis startswith reformulating the state-oriented approach for the domainof business processes to show what kind of sate space can beused in this domain. First, the approach is introducedinformally by means of an example. Next, a possibleformalization adjusted to the properties of business processesis discussed. Then, experimental evidences that the methodsuggested in the thesis can be used in practice are presented.The suggested method is also compared with other methods ofbusiness process modeling to find out the areas where it hasadvantages over the other methods. In the conclusion, theresults are summarized, and plansfor the future are drawn.</p><p>Most of the material included in the thesis has beenpublished and presented at international conferences. Thecontribution of this thesis consists in organizing the materialin support of the main hypothesis.</p>

Die Technische Universität Chemnitz startete 1995 als eine der ersten Einrichtungen mit dem Aufbau eines Volltextarchives unter dem Namen "Multimedia Online Archiv Chemnitz" (MONARCH). Durch die enge Zusammenarbeit von Universitätsrechenzentrum und Universitätsbibliothek ist MONARCH seitdem kontinuierlich weiterentwickelt worden, so dass für die Archivierung immer bessere Voraussetzungen bestehen. Die Serviceleistungen wurden erweitert und die Verarbeitung der Daten verbessert. Die Präsentation gibt Einblick in die Verknüpfung zwischen MONARCH und Bibliothek. Während das Rechenzentrum auf edv-technische Angelegenheiten spezialisiert ist (Datenformate, Unversehrtheit der Dokumente, Verarbeitung der Daten, Automatisierung von Arbeitsgängen, z.B. Meldungen an die Deutsche Bibliothek und den Südwestdeutschen Bibliotheksverbund Baden-Württemberg...), bearbeitet die Bibliothek in der Arbeitsgruppe MONARCH die bibliothekarischen Aufgaben. So wurden z.B. FAQ's und Hilfetexte erstellt, Formulare entworfen, Layoutfragen und Urheberrechtsprobleme diskutiert usw. Die Auskunfts- und Informationstätigkeit zu Online-Hochschulschriften wird beschrieben sowie der Geschäftsgang innerhalb der Bibliothek bis zum Nachweis der elektronischen Hochschulschriften im Volltext im OPAC der Universitätsbibliothek Chemnitz. In Zukunft wollen wir uns vor allem um die Verbesserung der Nutzerbetreuung und der Autorenberatung bemühen, besonders hinsichtlich der Vorbereitung und Durchführung der Archivierung sowie bei der Recherche nach archivierten Publikationen. Dabei soll die Eigenständigkeit und Verantwortung der Autoren bei der Archivierung gefördert werden. Unsere Aktivitäten erweitern wir auf eine enge Zusammenarbeit mit den Promotionsausschüssen der Fakultäten. Erfahrungswerte werden an dieser Stelle vermittelt. Abschließend wird ein Einblick in die zukünftigen Aufgaben zur Entwicklung von MONARCH gegeben.

Der Vortrag wurde auf dem 5. Workshop DissOnline: Abschlussworkshop des DFG-Projektes "Aufbau einer Koordinierungsstelle für elektronische Hochschulschriften" am 25. Februar 2005 gehalten. Der Datentransfer elektronischer Hochschulschriften an die Deutsche Bibliothek (DDB) sowie den Südwestdeutschen Bibliotheksverbund (SWB) ist erläutert. Die Technologie zur Erfassung, Aufbereitung und Datenübermittlung ist für das Meldeinterface DDB und SWB äquivalent. Dabei erfolgt die automatische Vergabe von Persistent Identifiern (URN) für jedes Dokument. Die per Onlineformular vom Autor eingetragenen Metadaten werden zur Abholung und Speicherung auf dem Server der Deutschen Bibliothek in das Format XMetaDiss transformiert und über die OAI Schnittstelle zum Download bereitgestellt. Für die in MONARCH achivierten Dissertationen und Habilitationen ist die Langzeitverfügbarkeit und der persistente Zugriff auf den Volltext gesichert.

Thesis (doctoral)--Universität Freiburg im Breisgau. / Includes bibliographical references (p. 215-235).

Mass spectrometry (MS) is a power analytical tool which is capable of analyzing biomolecules in great detail, both structurally and quantitatively. With regards to glycans, special considerations regarding sample preparation are necessary in order to achieve reproducible identification and relative quantification of these analytes. A workflow for isolation at the glycopeptide level and subsequent detection at the glycan level with phenylhydrazine, demonstrated that monoclonal antibodies (mAbs) containing a specific amino acid mutation were able to express approximately an additional 50% of the α2,6 disialylated glycan compared to their non-mutant analogues. In a second experiment using mAbs, an azide modified glycan (Ac4ManAz) was introduced both metabolically and enzymatically during mAb production. This glycan is a precursor in the sialic acid pathway and the azide moiety allows for specific chemistry post-production including the potential for highly specific enrichment. The results of this workflow demonstrated that [100 μM] of Ac4ManAz precursor added to the cell media was necessary for metabolic expression. More complex samples however, may contain multiple sites of glycosylation. To conserve the site of attachment, these molecules are often studied at the glycopeptide level, and require enrichment of glycopeptides to improve the lower signal intensity observed in the presence of co-eluting peptides. Carboxymethyl chitosan (CMCH) as well as amine-functionalized magnetic-nanoparticles (MNP) were developed as novel materials for this purpose. CMCH is naturally occurring, and therefore is cost-effective and readily available. In a 12 protein mixture CMCH demonstrated the bulk enrichment of glycopeptides yielding an approximately 20% higher enrichment of sialylated species as compared to a commercially available glycopeptide kit through the use of tandem mass tags for relative quantification. In the same approach, amine functionalized MNP were produced and used to enrich glycopeptides from tryptic digests. This approach was fast (about 10 mins) and quantitatively demonstrated improved retention for sialylated species. Examples of these techniques and their applications are reported in this work. / October 2015