Although thet:e has been gradual awat:eness of leat:ning disabilities aftet: Wodd Wat: II, it was in the late 1960's that compt:ehensive assessment and special education wet:e provided in schools. Specifically, in the at:ea of services for families, a reaffirmation of the fundamental rights of chilruen and families emerges. Although stress associated with the presence of a learning disabled child is an important consideration, its impact on the family is related to the family members' cognitive appraisal of the stress situation and thett copmg resources. Parents of learning disabled chilruen experience more stress, often exacerbated by faulty, misunderstood coping efforts that increase conflict in the family. Reseat:chers have investigated how: families manage stress; and cope with the multiple stt:esses of rearing a learning disabled children. It has been found that while many families cope, others cannot. Stress theory has dttected our attention to circumstances that weaken families and exacerbate distress. Preventative and ameliorative services at:e needed to assist such families. Stress and coping theory suggest that differences in families' reactions to learning disabilities may be related to amount and quality of resources available to pat:ents. This involves cognitive adaptation using coping skills, enabling them to t:e-evaluate stressful events positively. Another resource would be professionals, whose role would be of a facilitator, strengthening the ability of the family to gain access to needed services while increasing the family's mastery of coping with learning disability. Research has shown that parents' initial contact with learning disability and how to assist their learning disabled child was stressful. After parents received counselling on coping with their stress and stress management, and after the child's psycho-educational assessment and remedial measures were implemented, there has been significant positive feedback from parents and children. Research would embrace relationships between perceptions and family well-being using Ellis's rational-emotive therapy, thereby contributing to better understanding of how families cope with stress. Ayurvedic principles would be used to adopt a holistic approach to life. By using RET and A yurvedics the researcher was able to assist parents with learning disabled children to cope better with their stresses and effectively manage their child's learning disability. / Psychology of Education / D. Ed. (Psychology of Education)

Le virus de l’hépatite C (VHC) est un agent causateur de maladies du foie important responsable d’une pandémie affectant près de 180 millions d’individus mondialement. L’absence de symptômes dans les premières années d’infection entraîne des diagnostics tardifs qui empêchent la prise en charge rapide des patients avant l’apparition d’une fibrose et, dans près de 16 % des cas d’infection, d’une cirrhose. En exploitant les interactions protéine-protéine membranaires, des essais utilisant la technologie BRET, dans les cellules vivantes, ont été précédemment optimisés afin d’établir le réseau complet des interactions du VHC. En utilisant les fondements de cette étude, un essai à haut débit dans les cellules vivantes a été réalisé pour identifier de nouveaux composés anti-VHC ciblant une nouvelle interaction NS3/4A-NS3/4A. Approximativement 110,000 petites molécules ont été criblées pour leurs effets sur l’homodimérization de NS3/4A et ont été classées par rapport à leur spécificité et à leur puissance contre le VHC. Au terme de cette étude, UM42811 a été identifié comme un activateur potentiel de l’interaction NS3/4A-NS3/4A offrant une activité antivirale prometteuse dotant une excellente fenêtre thérapeutique. Par la suite, un séquençage exhaustif des virus, soumis à un traitement de UM42811, a permis d’établir le profil de résistance du VHC contre ce composé. Grâce à cette fine cartographie, il a été possible d’identifier un nouveau mécanisme d’inhibition de NS3/4A qui est indépendant de son activité protéase. En utilisant les données de notre groupe sur les interactions VHC-hôte, il a été possible de continuer la caractérisation fonctionnelle du composé UM42811 en étudiant son effet sur les interactions potentiellement bénéfiques à la persistance virale. Pour ce faire, les protéines associées au transport nucléaire et mitochondriale qui sont des interactants de choix de NS3/4A ont été priorisées. Parmi ces facteurs de l’hôte, l’étude de karyopherin subunit beta 1 (KPNB1) et de heat shock protein 60 (HSP60) a été priorisée. De façon intéressante, les expériences de co-immunoprécipitation ont démontré que UM42811 était capable de prévenir l’interaction KPNB1-NS3/4A ainsi que l’interaction HSP60-NS3/4A. De plus, les études ii fonctionnelles et les analyses d’immunobuvardage de type western ont démontré que l’interaction KPNB1-NS3/4A avait des effets délétères sur l’induction des gènes stimulés par l’interféron (ISG). Finalement, il a été démontré que KPNB1 est possiblement clivé par NS3/4A suggérant la présence potentielle d’un mécanisme de subversion ou d’échappement. En bref, cette étude démontre la puissance des stratégies impliquant les interactions protéine-protéine dans les cellules vivantes pour l’identification de nouveaux composés inhibiteurs, caractérise un nouveau mécanisme d’inhibition anti-VHC et révèle la possibilité d’un nouveau mécanisme d’évasion du système immunitaire. / Hepatitis C virus (HCV) is an important causative agent for liver diseases and is responsible for a worldwide pandemic affecting roughly 180 million individuals worldwide. Late diagnosis following the progression to fibrosis and to cirrhosis, in nearly 16% of chronic infections, is attributed to the absence of symptoms in the first years of infection. By exploiting membrane protein-protein interactions (PPI), live cell assays using bioluminescence resonance energy transfer (BRET) technology have previously been optimized to complete a comprehensive hepatitis C virus (HCV) protein interaction network. Using the groundwork laid by this network study, a high-throughput assay (HTS) cell-based assay was implemented to identify novel inhibitory compounds targeting an unreported NS3/4A-NS3/4A interaction. Approximately 110,000 compounds from a small-molecule collection were screened to monitor modulation of NS3/4A homodimerization and were discriminated based on specificity and potency. UM42811 was identified as a potential NS3/4A-NS3/4A interaction activator and found to have a promising antiviral activity boasting an excellent therapeutic window. Combined deep sequencing and mutation mapping have yielded a resistance profile based on statistical and functional probability pointing towards a novel inhibitory mechanism targeting the HCV NS3/4A independent from protease activity inhibition. Data from an HCV to host protein interaction network generated by our group was used to analyze alternative effects of UM42811 on interactions which potentially benefit viral persistence. NS3/4A-specific host interactors were heavily associated with nuclear and mitochondrial transport based on Gene Ontology (GO). Among these specific interactors, karyopherin subunit beta 1 (KPNB1) and heat shock protein 60 (HSP60) were selected for further study. Interestingly, co-immunoprecipitation experiments revealed that UM42811 was able to prevent both KPNB1-NS3/4A and HSP60-NS3/4A interactions. Moreover, functional and western analysis revealed the KPNB1-NS3/4A interaction to have deleterious effects on iv interferon stimulated gene (ISG) induction. Unexpectedly, analysis revealed a putative NS3/4A mediated cleavage of KPNB1. Overall, this study demonstrates the strength of cell-based PPI strategies in the identification of novel HCV antiviral compounds, characterizes a novel inhibitory mechanism for HCV and reveals a potentially novel viral immune evasion mechanism.

This thesis takes as its starting point the use of extracts from the works of historical authors who wrote in England in the early to mid twelfth-century. It focuses upon the ways in which their works began to be incorporated into three particular texts in the later twelfth and early thirteenth centuries. Through the medium of individual case studies – De Abbatibus (Abingdon), CCCC 139 (Durham) and The London Collection three elements are explored (i) how mediaeval writers used extracts from the works of others in ways which differed from modern practices with their concerns over charges of plagiarism and unoriginality (ii) how the structural and narrative roles which the use of extracts played within the presentation of these texts (iii) how the application of approaches developed in the twentieth century, which transformed how texts are now analysed, enabled a re-evaluation and re-interpretation of their use of source material with greater sensitivity to their original purposes This analysis casts fresh light upon the how and why these texts were produced and the means by which they fulfilled their purposes and reveals that despite their disparate origins and individual perspectives these three texts share two common features: (i) they follow a common three stage pattern of development (ii) they deal with similar issues: factional insecurities and concerns about the quality of those in power over them – using an historical perspective The analysis also reveals the range of techniques which were at the disposal of the composers of these texts, dispelling any notion that they were either unsophisticated or naïve in their handling of their source materials. Together these texts demonstrate how mediaeval authors used combinations of extracts as a means of responding quickly and flexibly to address particular concerns. Such texts were not regarded as being set in stone but rather as fluid entities which could be recombined at will in order to produce new works as required.

Vertically rolled-up microcavities are fabricated using differentially strained nanomembranes by employing rate and temperature gradients during electron beam evaporation of SiO2. The geometry of the rolled-up tubes is defined by a photo-lithographically patterned polymer sacrificial layer beneath the SiO2 layers that is dissolved to start the rolling. Rolled-up tubes support resonances formed by constructive interference of light propagating along the circumference. Optical studies are performed in the visible spectral range using a micro-photoluminescence (µPL) setup to excite and detect optical modes. Record high quality factors (Q factors) of 5400 for rolled-up resonators probed in PL-emission mode are found and their limits are theoretically investigated. Axial modes can also be supported when an increased winding number in the center is realized by appropriate pattern designs. In addition, higher order radial modes can be confined when atomic layer deposition (ALD) coatings are applied. Both types of modes are identified using polarization and spatially resolved µPL maps. Evanescent-wave coupling by tapered fibers and tubes on substrates is the second method used to study light confinement and to demonstrate frequency filtering in ALD coated rolled-up microcavities. Scans are performed by monitoring light from a tunable laser in the range of 1520-1570 nm after transmission through the tapered fiber. Dips in the spectrum are found and attributed to fundamental and axial resonant modes. Moreover, by coupling two tapered fibers to a lifted rolled-up microcavity, a four-port add-drop filter is demonstrated as a future component for vertical resonant light transfer in on-chip optical networks. Simulations show that the subwavelength tube wall thickness limits the Q factor at infrared wavelengths and ALD coatings are necessary to enhance the light confinement. After coating, two linear polarization states are found in experiment and fundamental and axial modes can be selectively excited by coupling the fiber to different positions along the tube axis. Spatially and polarization resolved transmission maps reveal a polarization dependent axial mode distribution which is verified theoretically. The results of this thesis are important for lab-on-chip applications where rolled-up microcavities are employed as high resolution optofluidic sensors as well as for future uses as waveguide coupled components in three-dimensional multi-level optical data processing units to provide resonant interlayer signal transfer.

Although thet:e has been gradual awat:eness of leat:ning disabilities aftet: Wodd Wat: II, it was in the late 1960's that compt:ehensive assessment and special education wet:e provided in schools. Specifically, in the at:ea of services for families, a reaffirmation of the fundamental rights of chilruen and families emerges. Although stress associated with the presence of a learning disabled child is an important consideration, its impact on the family is related to the family members' cognitive appraisal of the stress situation and thett copmg resources. Parents of learning disabled chilruen experience more stress, often exacerbated by faulty, misunderstood coping efforts that increase conflict in the family. Reseat:chers have investigated how: families manage stress; and cope with the multiple stt:esses of rearing a learning disabled children. It has been found that while many families cope, others cannot. Stress theory has dttected our attention to circumstances that weaken families and exacerbate distress. Preventative and ameliorative services at:e needed to assist such families. Stress and coping theory suggest that differences in families' reactions to learning disabilities may be related to amount and quality of resources available to pat:ents. This involves cognitive adaptation using coping skills, enabling them to t:e-evaluate stressful events positively. Another resource would be professionals, whose role would be of a facilitator, strengthening the ability of the family to gain access to needed services while increasing the family's mastery of coping with learning disability. Research has shown that parents' initial contact with learning disability and how to assist their learning disabled child was stressful. After parents received counselling on coping with their stress and stress management, and after the child's psycho-educational assessment and remedial measures were implemented, there has been significant positive feedback from parents and children. Research would embrace relationships between perceptions and family well-being using Ellis's rational-emotive therapy, thereby contributing to better understanding of how families cope with stress. Ayurvedic principles would be used to adopt a holistic approach to life. By using RET and A yurvedics the researcher was able to assist parents with learning disabled children to cope better with their stresses and effectively manage their child's learning disability. / Psychology of Education / D. Ed. (Psychology of Education)

SILVA, Marilete Geralda da. As expectativas e a participação dos pais no processo de desenvolvimento e escolarização do filho diagnosticado com Transtorno de Déficit de Atenção/Hiperatividade - TDA/H. 2007. 247f. Tese (Doutorado em Educação) – Universidade Federal do Ceará, Faculdade de Educação, Programa de Pós-Graduação em Educação Brasileira, Fortaleza-CE, 2007. / Submitted by Raul Oliveira (raulcmo@hotmail.com) on 2012-08-06T14:36:00Z No. of bitstreams: 1 2007_TESE_MGSILVA.pdf: 2245027 bytes, checksum: 2e7f0c8bf7fc5ae997419fcf20cf563a (MD5) / Approved for entry into archive by Maria Josineide Góis(josineide@ufc.br) on 2012-08-09T11:15:45Z (GMT) No. of bitstreams: 1 2007_TESE_MGSILVA.pdf: 2245027 bytes, checksum: 2e7f0c8bf7fc5ae997419fcf20cf563a (MD5) / Made available in DSpace on 2012-08-09T11:15:45Z (GMT). No. of bitstreams: 1 2007_TESE_MGSILVA.pdf: 2245027 bytes, checksum: 2e7f0c8bf7fc5ae997419fcf20cf563a (MD5) Previous issue date: 2007 / The present study aimed to understand the relations between the expectations and the forms of participation of the parents in the development and the schooling of the children diagnosed with the Attention Deficit Disorder/ Hyperactivity - ADD/H based on the fact that parents are privileged partners in the education of the children. So for such objective to be reached, a study of four cases of children diagnosed with this disorder (three boys and a girl) and its respective parents was done in the age-group from seven to ten years old when the beginning of the study during the first semester of 2005. For the research of the data collection, guided interviews and participant observations were carried out. The interviews had been carried through with the parents, the children, the professors and pedagogical coordinator of the schools where these children studied at the beginning and in the end of the period of the terms during the semester of each institute. The participant observations happened in the contexts of the house and the school of each child and also in other environments (the sports court, the private teacher´s house, in the course of Mathematics, in the Resource Center, in the presentations of bumba-meu-boi and in the street). The collected data had been organized and categorized from the technique of the content analysis. To the written registers of the participant observations, gathered data of the photographic and phonographic registers were added. These registers were transformed into descriptive texts of the interactions between the citizens of the research. The gathered and organized data were mainly analyzed and interpreted from the psychoanalytical perspective and authors who argue the participation of the parents at school and also the process of pertaining to school inclusion of children with educative special necessities. Taking into consideration the limits of the methodology of this case study, some conclusive inferences related to the applied work were pointed out. They are as follows: the parents have expectations concerning to the development, the schooling and the professionalization of the children, such as the other parents, but they hope the children develop principally good attitudes; the expectations nor always were positive and evidenced to be influenced by the context of the difficulties and easinesses of the children. The participation of the parents has mainly characterized for the search of some professionals to help them in the accompaniment of the children; for the guilt they have concerning to the difficulties of the child; for the monitoring, for the attachment and devotion of the mothers and for the apart participation of the father; and the difficulty in understanding the behavior of the child because of the effects of the medicine regarding the symptoms of the ADD/H. The school attendance is pointed out by the parents as the main factor that helps and makes it difficult the participation in the development and the schooling of the children. The relation between expectations and participation showed: that there is no linearity between them; that not always the participation form is favorable to the reach of the expectations; that expectations and forms of participation point the place that the children occupy in the desire of their parents; that the feelings of the parents related to the children are ambivalent; that a high investment in the participation and the no return of what is waited can generate negative expectations and that not always all participation of the parents is synonymous of help for the child, the school and the proper family. The children perceive that the parents yearn they learn good attitudes and change their behavior; they behave themselves (verbally) in a passive and childish way ahead of the aids that receive; they show good feelings concerning to the classmates and teachers; they also show motivation and independent behavior to carry out their activities at some moments of the study, but they also demonstrate to mobilize some people of the family with their tasks; they have consciousness of the symptoms of the ADD/H that are attributed and show some mistrust of being discriminated for that. Expectations and forms of participation also evidence that the symbolic statute of this disturb is being a great fact, so that the course of the development of these children has already been traced, and it prevents them to make enigmas to their parents. The study also revealed that the attendance excused to the children with ADD/H and their parents at school was not a reflection of inclusion. / Partindo da constatação de que os pais são parceiros privilegiados na educação das crianças, o presente estudo teve como propósito compreender as relações entre as expectativas e as formas de participação dos pais no desenvolvimento e escolarização das crianças diagnosticadas com o Transtorno de Déficit de Atenção/Hiperatividade – TDA/H. Para que tal objetivo fosse alcançado, realizei estudo de quatro casos de crianças diagnosticadas com este transtorno (três meninos e uma menina) e seus respectivos pais, na faixa etária de sete a dez anos quando do início do estudo, durante o primeiro semestre de 2005. Para a coleta dos dados da pesquisa, realizei entrevistas orientadas e observações participantes. As entrevistas foram realizadas com os pais, com as crianças, com as professoras e coordenador pedagógico das escolas onde estas crianças estudavam, no início e no final do semestre letivo de cada estabelecimento. As observações participantes aconteceram nos contextos da casa e da escola de cada uma e noutros ambientes (na quadra de esportes, na casa da professora particular, no curso de Matemática, na Sala de Recurso, em apresentações de bumba-meu-boi e na rua). Os dados coletados foram organizados e categorizados a partir da técnica da análise de conteúdo. Aos registros escritos das observações participantes, acrescentei dados coletados do registro fotográfico e fonográfico. Estes registros foram transformados em textos descritivos das interações entre os sujeitos da pesquisa. Os dados colhidos e organizados foram analisados e interpretados, principalmente, a partir da perspectiva psicanalítica e de autores que discutem a participação dos pais na escola e o processo de inclusão escolar de crianças com necessidades educativas especiais (NEE). Levando em consideração os limites da metodologia do estudo de caso, apontei algumas inferências conclusivas em relação ao trabalho realizado. São elas: os pais têm expectativas em relação ao desenvolvimento, escolarização e profissionalização dos filhos, como os outros pais, mas esperam, principalmente, que desenvolvam boas atitudes; as expectativas nem sempre foram positivas e evidenciaram ser influenciadas pelo contexto das dificuldades e facilidades das crianças. A participação dos pais se caracterizou, principalmente, pela procura de vários profissionais para ajudá-los no acompanhamento dos filhos; pela culpa que nutrem em relação às dificuldades da criança; pela vigilância, pelo apego e dedicação das mães e pela participação marginal do pai; e pela dificuldade em entender a conduta da criança por causa dos efeitos da medicação para os sintomas do TDA/H. O atendimento escolar é apontado pelos pais como o principal fator que facilita e que dificulta a participação no desenvolvimento e escolarização dos filhos. A relação entre expectativas e participação mostrou: que não há linearidade entre elas; que nem sempre a forma de participação é favorável ao alcance das expectativas; que expectativas e formas de participação apontam o lugar que as crianças ocupam no desejo de seus pais; que os sentimentos dos pais em relação aos filhos são ambivalentes; que o alto investimento na participação e o não retorno do que é esperado pode gerar expectativas negativas e que nem toda forma de participação dos pais é sinônimo de ajuda para a criança, para a escola e para a própria família. As crianças percebem que os pais anseiam que formem boas atitudes e que mudem de comportamento; quando indagadas, posicionam-se (verbalmente) de forma passiva e infantilizada diante das ajudas que recebem; revelam bons sentimentos em relação à escola e ensaiam algumas críticas em relação aos colegas e professoras; também demonstraram motivação e conduta autônoma para realizarem suas atividades em vários momentos do estudo, mas evidenciaram mobilizar várias pessoas da família com os seus afazeres; têm consciência dos sintomas do TDA/H que lhes são atribuídos e revelam o receio de serem discriminados por isso. Expectativas e formas de participação também demonstraram que o estatuto simbólico deste transtorno está sendo um fator de peso para que o curso do desenvolvimento destas crianças já esteja traçado, impedindo-as de se fazerem enigmas aos seus pais. O estudo também revelou que o atendimento dispensado às crianças com TDA/H e seus pais na escola não foi fruto de uma proposta refletida de inclusão.

Vertically rolled-up microcavities are fabricated using differentially strained nanomembranes by employing rate and temperature gradients during electron beam evaporation of SiO2. The geometry of the rolled-up tubes is defined by a photo-lithographically patterned polymer sacrificial layer beneath the SiO2 layers that is dissolved to start the rolling. Rolled-up tubes support resonances formed by constructive interference of light propagating along the circumference. Optical studies are performed in the visible spectral range using a micro-photoluminescence (µPL) setup to excite and detect optical modes. Record high quality factors (Q factors) of 5400 for rolled-up resonators probed in PL-emission mode are found and their limits are theoretically investigated. Axial modes can also be supported when an increased winding number in the center is realized by appropriate pattern designs. In addition, higher order radial modes can be confined when atomic layer deposition (ALD) coatings are applied. Both types of modes are identified using polarization and spatially resolved µPL maps. Evanescent-wave coupling by tapered fibers and tubes on substrates is the second method used to study light confinement and to demonstrate frequency filtering in ALD coated rolled-up microcavities. Scans are performed by monitoring light from a tunable laser in the range of 1520-1570 nm after transmission through the tapered fiber. Dips in the spectrum are found and attributed to fundamental and axial resonant modes. Moreover, by coupling two tapered fibers to a lifted rolled-up microcavity, a four-port add-drop filter is demonstrated as a future component for vertical resonant light transfer in on-chip optical networks. Simulations show that the subwavelength tube wall thickness limits the Q factor at infrared wavelengths and ALD coatings are necessary to enhance the light confinement. After coating, two linear polarization states are found in experiment and fundamental and axial modes can be selectively excited by coupling the fiber to different positions along the tube axis. Spatially and polarization resolved transmission maps reveal a polarization dependent axial mode distribution which is verified theoretically. The results of this thesis are important for lab-on-chip applications where rolled-up microcavities are employed as high resolution optofluidic sensors as well as for future uses as waveguide coupled components in three-dimensional multi-level optical data processing units to provide resonant interlayer signal transfer.

No description available.

This thesis deals with child problems with ADHD/ADD at Primary school and their next diagnosis.The aim of the theoretical part was to focus on the latest and available knowledge in the sphere of education and upbringing. Some thematical plans were analysed and they consider of ADHD/ADD and Specific learning disorders.The aim of the practical part was the analysis of school experience with children with ADHD/ADD. The problem was assessed from many points of view through casuists and interview with children, teachers, parents or assistents. That comes from the theoretical part.

This diploma thesis describes how to create or convert traditional Java programs to desktop-like rich internet applications with the Google Web Toolkit. The Google Web Toolkit is an open source development environment, which translates Java code to browser and device independent HTML and JavaScript. Most of the GWT framework parts, including the Java to JavaScript compiler as well as important security issues of websites will be introduced. The famous Agricola board game will be implemented in the Model-View-Presenter pattern to show that complex user interfaces can be created with the Google Web Toolkit. The Google Web Toolkit framework will be compared with the JavaServer Faces one to find out which toolkit is the right one for the next web project. / Diese Diplomarbeit beschreibt die Erzeugung desktopähnlicher Anwendungen mit dem Google Web Toolkit und die Umwandlung klassischer Java-Programme in diese. Das Google Web Toolkit ist eine Open-Source-Entwicklungsumgebung, die Java-Code in browserunabhängiges als auch in geräteübergreifendes HTML und JavaScript übersetzt. Vorgestellt wird der Großteil des GWT Frameworks inklusive des Java zu JavaScript-Compilers sowie wichtige Sicherheitsaspekte von Internetseiten. Um zu zeigen, dass auch komplizierte graphische Oberflächen mit dem Google Web Toolkit erzeugt werden können, wird das bekannte Brettspiel Agricola mittels Model-View-Presenter Designmuster implementiert. Zur Ermittlung der richtigen Technologie für das nächste Webprojekt findet ein Vergleich zwischen dem Google Web Toolkit und JavaServer Faces statt.