Le Trouble obsessionnel-compulsif (TOC) de l’enfant et de l’adolescent est un trouble fréquent mais encore peu reconnu. Le traitement de première intention est la thérapie cognitive et comportementale (TCC). Les objectifs de cette étude sont de démontrer la faisabilité d’un protocole de TCC en population clinique et de montrer l’évolution symptomatique pendant 18 mois. Neuf patients présentant un TOC âgés de 6 à 16 ans ont reçu 12 séances hebdomadaires de TCC. Une évaluation est réalisée avant et après le traitement puis tous les 6 mois pendant 18 mois, elle comprend la mesure des TOC (CY BOCS), également des symptômes anxieux (ECAP), de dépression (CDI), une échelle de fonctionnement global (C GAS) et d’amélioration (CGI). Trois subtests du WISC IV permettent d’analyser les capacités attentionnelles. Résultats : les patients s’améliorent de 46% à la CY BOCS après la TCC, de 69% à 18 mois. Les variations intra-individuelles montrent des profils évolutifs différents : réponse très rapide puis rémission, amélioration retardée suivie de rémission ou amélioration puis rechute. Un seul patient n’est pas répondeur. Un changement psychologique dans une optique différentielle et intra individuelle, par des techniques de ré échantillonage (Bootstrap) et de comparaison des profils (test de Kolmogorov-Smirnof) est observé pour les patients les plus sévèrement atteints initialement. Conclusions : Un protocole de TCC dans le TOC de l’enfant et de l’adolescent est réalisable en population clinique. L’efficacité est montrée et se poursuit pendant les 18 mois. La TCC permet une amélioration globale (CGI, C GAS), symptomatique (CY BOCS, ECAP, CDI) et cognitive (WISC IV). / Pediatric obsessive-compulsive disorder (OCD) is a frequent but a not usually recognized trouble. The first –line treatment is cognitive-behavioral therapy (CBT). Objective : To demonstrate the feasibility of CBT protocol delivered in an outpatient community-based clinic and to evaluate clinic symptoms at 18 months follow-up. Nine participants (age 6-16 years) received 12 CBT weekly sessions. Assessment is realized at pre and post treatment, and every 6 months during 18 months, including symptoms of TOC (CY BOC), of anxiety(ECAP), of depression ((CDI), global functioning (C GAS) and improvement (CGI). Three WISC IV subtests allow attentional capacity analysis. Results: patients improvements are : 46% at post treatment, and 69% at 18 months follow up. The intra-individual variations show differents evolutionary profiles : quick response and remission, delayed improvement followed by remission or improvement followed by relapse. Only one is non responder. A psychological change in a differential and intra-individual optical, with sample rate (Bootstrap) and profiles comparaison (test de Kolmogorov-Smirnof) is observed for the pre treatment more severe patients. Conclusions : CBT protocol of OCD in children and adolescent is feasible in community-base clinic. Efficiency is showed and continues during 18 months. CBT allows global (CGI, C GAS), symptom (CY BOCS, ECAP, CDI) and cognitive (WISC IV) improvements.

L’objectif de cette étude était de démontrer que le léchage excessif de surface (LES) chez le chien représente un signe clinique d’un trouble digestif sous-jacent plutôt qu’un trouble obsessionnel compulsif. Vingt chiens présentés pour LES (groupe L) ont été divisés en 2 sous-groupes de 10 chiens chacun : L0, sans, et LD, avec des signes cliniques digestifs concomitants. Dix chiens en santé ont été assignés à un groupe contrôle (groupe C). Une évaluation comportementale complète, un examen physique et neurologique ont été réalisés avant un bilan diagnostic gastro-intestinal (GI) complet (hématologie, biochimie, analyse urinaire, mesure des acides biliaires pré et post-prandiaux et de l’immunoréactivité spécifique de la lipase pancréatique canine, flottaison fécale au sulfate de zinc, culture de selles, échographie abdominale et endoscopie GI haute avec prise de biopsies). En fonction des résultats, un interniste recommandait un traitement approprié. Les chiens étaient suivis pendant 90 jours durant lesquels le comportement de léchage était enregistré. Des troubles GI ont été identifiés chez 14/20 chiens du groupe L. Ces troubles GI sous-jacents incluaient une infiltration éosinophilique du tractus GI, une infiltration lymphoplasmocytaire du tractus GI, un retard de vidange gastrique, un syndrome du côlon irritable, une pancréatite chronique, un corps étranger gastrique et une giardiose. Une amélioration >50% en fréquence ou en durée par rapport au comportement de léchage initial a été observée chez une majorité de chiens (56%). La moitié des chiens ont complètement cessé le LES. En dehors du LES, il n’y avait pas de différence significative de comportement (p.ex. anxiété), entre les chiens L et les chiens C. Les troubles GI doivent être considérés dans le diagnostic différentiel du LES chez le chien. / The objective of this study was to characterize excessive licking of surfaces (ELS) in dogs and demonstrate that it can be a sign of underlying gastrointestinal (GI) pathology rather than an obsessive-compulsive disorder. Twenty dogs presented with ELS (L group) were divided in 2 subgroups of 10 dogs each: L0 without and LD with concomitant digestive signs. Ten healthy dogs were assigned to a control group (C group). Behavioral, physical and neurological examinations were performed prior to a complete work-up of the GI system (CBC, serum chemistry panel, urinalysis, assessment of total serum bile acids and canine specific pancreatic lipase immunoreactivity, fecal flotation by zinc sulfate, fecal culture, abdominal ultrasonography and upper GI endoscopy with biopsies). Based on results, appropriate treatment was recommended. Dogs were monitored subsequently for 90 days during which the licking behavior was recorded. Gastrointestinal disorders were identified in14/20 L dogs. Underlying GI disorders included eosinophilic infiltration of the GI tract, lymphoplasmacytic infiltration of the GI tract, delayed gastric emptying, irritable bowel syndrome, chronic pancreatitis, gastric foreign body and giardiasis. Significant improvement (>50%) in frequency or duration of the basal ELS behavior was observed in the majority of dogs (56%). Resolution of ELS occurred in half of the L dogs. Except for ELS, there was no significant difference in the behavior (e.g. anxiety) of L dogs and C dogs. GI disorders should be considered in the differential diagnosis of ELS in dogs

Thèse numérisée par la Division de la gestion de documents et des archives de l'Université de Montréal.

Depuis une vingtaine d’années, le modèle cognitif basé sur les interprétations (Groupe de recherche sur la cognition dans le trouble obsessionnel compulsif [OCCWG], 1997, 2001, 2003, 2005) représente le modèle psychologique de l’étiologie et du maintien du TOC le plus étudié au plan empirique. Cependant, peu de recherches ont porté sur les deux postulats importants du modèle touchant respectivement le développement des croyances liées à l’obsessionnalité et la contribution des états affectifs au maintien des interprétations et des croyances (réactivité cognitive). L’objectif de cette thèse est de contribuer à la validation empirique de ces postulats. Fondé sur un devis corrélationnel dans un échantillon de participants mixte (participants troubles obsessionnels-compulsifs et participants non cliniques), le premier article étudie les liens entre les expériences de l’enfance et la présence de croyances obsessionnelles chez l’adulte. Deux modèles alternatifs sont comparés qui représentent d’une part un lien spécifique, et d’autre part un lien non spécifique entre les expériences de l’enfance et les croyances obsessionnelles adultes. Les résultats suggèrent la présence à la fois de relations spécifiques et non spécifiques entre les expériences de l’enfance et les croyances adultes. Les expériences de l’enfance et les domaines de croyance obsessionnels qui montrent des liens spécifiques sont ceux relatifs à la responsabilité, à la perception du danger, et au perfectionnisme. En contrepartie, les expériences de l’enfance relatives à la perception de danger et dans une moindre mesure la sociotropie, apparaissent étroitement liés à la plupart des domaines de croyances adultes (intolérance à l’incertitude, surestimation du danger, importance et contrôle des pensées). Dans la seconde étude, nous nous intéressons à la mesure et l’analyse longitudinales de la réactivité cognitive telle qu’elle s’exprime dans l’environnement naturel de huit participants troubles obsessionnels-compulsifs de type ruminateur. Par le biais de huit protocoles à cas uniques intensifs, l’analyse de contingence entre les scores quotidiens d’humeur (4 états émotionnels cotés par participant) et d’interprétations (une interprétation idiographique des intrusions par participant) permet d’établir une mesure de l’importance de la réactivité cognitive chez chaque participant. Ces résultats sont ensuite analysés du point de vue des postulats principaux de deux modèles spécifiques de la réactivité cognitive (modèle de l’Infusion de l’affect [Forgas, 2008] et modèle de l’Humeur comme intrant [Meeten & Davey, 2011]. Ainsi, les analyses intra-individuelles répétées trans-comportements) et interindividuelles (trans-participants) permettent d’illustrer le rôle proximal déterminant des stratégies de traitement de l’information (traitement systématique; traitement superficiel; traitement altéré) employées par les participants. En résumé, les résultats obtenus dans ces deux études fournissent des données utiles à la poursuite de la validation du modèle des interprétations du TOC. Dans la première étude, l’identification de liens spécifiques entre les EE et les croyances obsessionnelles soutient la séquence étiologique postulée, alors que l’identification de liens non spécifiques suggère que d’autres trajectoires étiologiques peuvent être pertinentes. Dans la seconde étude, l’analyse longitudinale et naturaliste des covariations humeur – interprétations se révèle d’abord féconde à identifier les phénomènes de réactivité cognitive postulés dans le modèle des interprétations. Ensuite, en conformité aux modèles intégrés de la réactivité cognitive, l’analyse des liens entre cette réactivité et les stratégies privilégiées de neutralisation des participants permet d’identifier le rôle clé des différentes stratégies de traitement de l’information dans la réactivité cognitive. / Over the past twenty years, the «appraisal model» of obsessive-compulsive disorder (OCD) (Obsessive Compulsive Cognition Working Group, 1997, 2001, 2003, and 2005) has drawn most of the empirical research on the psychological etiology and maintenance of the disorder. Nevertheless, only a few studies addressed two important postulates of the model, which is the development of beliefs associated with OCD, and the contribution of affective states to the maintenance of appraisals and beliefs (p. ex., cognitive reactivity). The current thesis aims to contribute to the empirical validation of these postulates. Based on a retrospective correlational design in a mixed (OCD and normal) sample, the first article aims to explore the links between childhood experiences (CEs) and adult OCD related beliefs. Two alternative etiological models are compared emphasizing either a rather specific association between different CEs and beliefs; or conversely, a broad non-specific association between CEs and different OCD related beliefs. Results support both the existence of specific and non-specific associations between CEs and beliefs. CEs and OCD related beliefs that showed specific links were those CEs that showed specific links to OCD related beliefs were those related to the concepts of Responsibility (R-E and OBQ-R), Threat perception (TP-E et OBQ-T), and Perfectionism (SO-E et OBQ-P). On the other hand, CEs emphasizing Threat perception (TP-E) and Sociotropy (SOC-E) related experiences also showed significant links with most OCD related beliefs (Intolerance of uncertainty [OBQ-U], Overestimation of threat [OBQ-T], Importance and Control of thoughts [OBQ-I et OBQ-C]). The aim of the second article is to assess and analyze cognitive reactivity in an OCD sample (rumination subtype) through a longitudinal naturalistic design (eight intensive single-case designs). In a first step, the contingency analysis between daily mood-states scores (4 mood-states in each participant) and daily thought appraisals (one idiosyncratically defined thought appraisal in each participant) allows for the assessment of the magnitude and rate of cognitive reactivity in each participant. On the basis of integrative models of cognitive reactivity (Affect Infusion Model, and Mood as input Hypothesis) further repeated intra-individual analyses (across subjects) and inter-individual analyses (between subjects) illustrate the critical proximal role of different processing strategies used by the participants. In summary, both studies provide results that contribute to further the validation of the appraisal model of OCD. In the first study, the identification of specific links between CEs and OCD related beliefs in adults supports the postulated etiological sequence; while the identification of non-specific links suggest that other etiological paths may be relevant In the second study, the longitudinal investigation of covariations between mood-states and appraisals of thoughts allows to reveal the expected cognitive reactivity processes. Such processes are further supported with reference to integrated models of cognitive reactivity that emphasize the critical role of different processing strategies in their expression.

This diploma thesis deals with the issue of compulsive buying, phenomenon which is a current topic for today's society and its incidence is rising. The area of oniomania includes psychological but also social and financial aspects of the disorder. The thesis focuses mainly on the sphere of introduction of oniomania, as a great danger to man and society, especially in the context of financial illiteracy. Enough room is devoted to explication of main key words from the area of addictions (drug addictions and behavioral addictions). Attention has also been dedicated to an important chapter of the issue of gender in context to the pathological shopping and also to topics of getting to know the possibilities of treatment and prevention. The practical part of the thesis deals with research of level of awareness and orientation issues of shopping addiction among university students Using analysis of submitted questionnaires, this part of the thesis tries to find answers to fundamental questions related to the theme of financial literacy.

Introdução: O presente estudo tem como objetivo avaliar a eficácia da estimulação magnética transcraniana de repetição (EMTr) em freqüência excitatória, aplicada ao córtex pré-frontal dorsolateral direito (CPFDLd), quando adicionada ao tratamento vigente de pacientes com transtorno obsessivocompulsivo (TOC) resistente. Método: 30 pacientes com TOC resistente ao tratamento foram alocados aleatoriamente para receber EMTr ativa ou placebo, sendo que a condição de tratamento permaneceu oculta para pacientes e avaliador. O tratamento vigente permaneceu estável por ao menos 8 semanas. A EMTr foi realizada com uma bobina em formato de oito à freqüência de 10Hz, com 110% do limiar motor em 30 sessões diárias de 40 séries de 5 segundos com 25 segundos de intervalo. A gravidade dos sintomas foi avaliada inicialmente, após 2 e 6 semanas de tratamento e 2 e 6 semanas de seguimento com a escala de Yale-Brown para avaliação de sintomas obsessivo-compulsivos (Y-BOCS), Escala de Impressão Clínica Global (CGI), Escala de Hamilton para ansiedade (HAM-A), Escala de Hamilton para depressão com 17 itens (HAM-D17), e inventário SF-36 de qualidade de vida. A medida primária de eficácia foi definida como redução de 30% ou mais nos escores da Y-BOCS e avaliação melhor ou muito melhor na sub-escala de melhora clínica da CGI ao término do seguimento. Resultados: A análise da medida primária de eficácia revelou que apenas um paciente em cada grupo preencheu critérios de resposta para o tratamento com EMTr (P=1.00). A análise de medidas repetidas dos escores de Y-BOCS mostrou um efeito significativo do tempo (F=7.33, P=0.002). Entretanto, não foi observada diferença entre os grupos ou interação grupo/tempo. A análise de medidas repetidas da CGI (gravidade), HAM-D17 e HAM-A também mostrou efeito significativo do tempo (P<0.001, =0.001 e <0.001 respectivamente), novamente sem diferença significativa entre os grupos ou interação. Conclusão: EMTr excitatória aplicada ao CPFDLd de pacientes com TOC resistente ao tratamento não foi diferente de placebo na redução de sintomas obsessivo-compulsivos ou melhora da impressão clínica global. Entretanto, ocorreu uma resposta placebo significativa / Introduction: The present study aims to evaluate the efficacy of added excitatory repetitive transcranial magnetic stimulation (rTMS), applied to the right dorsolateral prefrontal cortex in patients with treatment resistant obsessive-compulsive disorder (OCD). Methods: 30 treatment resistant OCD outpatients were randomized to receive either active or sham rTMS, remaining both patients and rater blind to treatment condition. Baseline treatment was kept stable for at least 8 weeks, and rTMS was performed with a figure-of-eight coil at 10Hz, 110% of motor threshold at 30 daily sessions of 40 trains of 5 seconds with 25 seconds interval. Symptom severity was determined at baseline and after 2 and 6 weeks of treatment and further 2 and 6 weeks of follow-up, using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), Clinical Global Impression Scale (CGI), Hamilton Anxiety Rating Scale (HAM-A), Hamilton Depression Rating Scale (HAM-D17) and SF-36 quality of life inventory. The primary outcome measure was defined as 30% or more improvement in Y-BOCS scores and a much improved or improved score at the CGIimprovement subscale by the end of follow up. Results: The analysis of primary outcome measure revealed that only one patient on each group met response criteria for treatment with rTMS (P=1.00). Repeated-measures analysis of Y-BOCS scores showed a significant effect of time (F=7.33, P=0.002). However, no significant group effect or group by time interaction was observed. Repeated measures analysis of CGI (severity), HAM-D17 and HAM-A also showed a significant effect of time (P<0.001, =0.001 and <0.001 respectively) with no significant group effect or group by time interaction. Conclusion: Excitatory rTMS delivered to the rDLPFC of treatment resistant OCD patients was not different from placebo in reducing obsessive-compulsive symptoms or improving clinical global impression. However, a significant placebo response occurred

Introdução: O Transtorno de Escoriação (TE) é caracterizado pelo comportamento repetitivo e excessivo de escoriar a pele saudável, resultando em dano tecidual e significativo sofrimento, associado a ânsia incontrolável e falha em controlar tal comportamento repetitivo. Atualmente o TE é classificado na seção de transtornos relacionados aos Transtornos Obsessivo-compulsivos (TOC) da 5ª edição do Manual de Diagnóstico e Estatística de Transtornos Mentais (DSM). No entanto, ainda existem debates a respeito da sua classificação, se o mesmo está relacionado a transtornos relacionados ao TOC, ou se é melhor conceituado como uma dependência comportamental. Objetivos: O presente estudo comparou um grupo de indivíduos com TE com dois paradigmas dos transtornos obsessivo-compulsivos, i.e., TOC, e dos transtornos impulsivo-aditivos, i.e., Transtorno do Jogo (TJ), analisando suas características sociodemográficas, clínicas, categorias diagnósticas, perfil de comorbidades, sintomas obsessivo-compulsivos, traços impulsivos e atributos de personalidade. O objetivo de tal comparação foi avaliar se o TE estaria mais relacionado aos transtornos relacionados ao TOC ou ao TJ. Métodos: Participaram do estudo 121 pacientes, que procuraram o tratamento no Instituto de Psiquiatria (IPq) do Hospital das Clínicas da Faculdade de Medicina da Universidade São Paulo (HCFMUSP), Brasil. Do total de 121 participantes, 40 foram diagnosticados com TE, 41 com TOC e 40 com TJ. Foram utilizadas entrevistas clínicas estruturadas para diagnosticar e comparar os três grupos na sobreposição diagnóstica e nas comorbidades psiquiátricas atuais, e escalas de autopreenchimento padronizadas para avaliar os sintomas dimensionais e comparar os três grupos em análise dimensional. Resultados: O grupo TE apresentou maior preponderância de mulheres, mais jovens e com maior instrução acadêmica. Na análise categorial TE se aproximou, significativamente, mais de TOC (n = 14) do que de TJ (n = 3), se sobrepondo ao primeiro. Os grupos TE e TOC também foram mais propensos a apresentar outros Comportamentos Repetitivos Focados no Corpo (CRFC) e transtornos ansiosos em geral. A presença de CRFC diferenciou TE de TJ, por outro lado, TE se diferenciou de TOC pela presença de comportamentos aditivos. A análise dimensional demonstrou que TE se apresenta como um modelo híbrido de obsessividade-compulsividade e impulsividade. Finalmente, a análise de correlação mostrou que os escores de obsessividade-compulsividade e impulsividade não foram correlacionados à gravidade dos sintomas de escoriação da pele. Discussão: Os dados da análise categorial apoiam a classificação de TE como um transtorno correlato ao TOC. Já os achados das análises dimensionais sugerem que uma apresentação psicopatológica híbrida de TE, contendo tanto elementos obsessivo-compulsivos, como com traços impulsivos. No entanto, nenhum desses aspectos foram correlacionados à gravidade dos sintomas de escoriação no grupo TE, sugerindo que o comportamento de escoriação da pele é independente desses fatores nestes indivíduos. O conjunto de tal apresentação sucinta a alocação de TE junto ao grupo dos chamados CRFC. Conclusão: TE apresenta um perfil demográfico e clínico próprios. TE e TOC compartilham mais similaridades no perfil de comorbidades psiquiátricas do que TJ, a maioria baseada nos transtornos ansiosos. Por outro lado, TE se diferencia de TOC, por uma associação mais frequente com os transtornos aditivos. TE apresentou níveis intermediários de compulsividade e impulsividade na abordagem dimensional. O comportamento de escoriação não mostrou correlação relevante com as medidas dimensionais de compulsividade nem impulsividade. TE, de uma forma geral, teve uma associação robusta com os outros CRFC, diferenciando-se de TOC e de TJ. TE poderia ser classificado em uma sessão à parte juntamente com outros CRFC / Introduction: Excoriation Disorder (ED) is characterized by repetitive and excessive picking on healthy skin, resulting in significant skin damage and psychological distress associated with uncontrollable urge and failure to control this repetitive behavior. ED is currently classified under the Obsessive-compulsive and Related Disorders (OCRD) section of the Diagnostic and Statistics Manual of Mental Disorders - 5th edition. Nevertheless, there is still no consensus whether ED is more closely related to OCRDs or it would be better conceptualized as a behavioral addiction. Objectives: Compare ED patients with two paradigms of obsessive-compulsive disorders (OCD) and impulsive-addictive disorders (gambling disorder), analyzing their sociodemographic and clinical characteristics, diagnostic categories, comorbidity profile, obsessive-compulsive symptoms, impulsive traits, and personality features. The purpose of this comparison was to assess whether ED was more related to OCD-related disorders (OCDRD) or to behavioral addictions, e.g., Gambling Disorder (GD). Methods: Study participants were 121 patients seeking treatment at Instituto de Psiquiatria (IPq), Hospital das Clinicas da Faculdade de Medicina da Universidade Sao Paulo (HCFMUSP), Sao Paulo, Brasil. Of the 121 participants, 40 were diagnosed with ED, 41 with OCD, and 40 with GD. Structured clinical interviews were used to diagnose and compare the three groups in diagnostic overlap and current psychiatric-comorbidities, and standardized self-reports were used to evaluate the dimensional variables. Results: Participants in the ED group were more likely to be women, young, and with higher levels of education compared with those of the other groups. In the categorical analysis, ED was more significantly approached to OCD (n=14) than to GD (n=3), overlapping the first. In general, ED and OCD were also more likely to exhibit other body-focused repetitive behaviors (BFRB) and anxiety disorders. The presence of BFRB differentiated ED from GD. In contrast, ED differed from OCD by the presence of addictive behaviors. The dimensional analysis found that ED is a hybrid model of obsessive-compulsivity and impulsivity. Discussion: Categorical analysis supports the classification of ED as OCDRD; however, ED presented differences that may share underlying characteristics with OCD (e.g., compulsivity) and behavioral addiction (e.g., impulsivity). Dimensional analysis suggests a heterogeneous psychopathological in ED with both obsessive-compulsive and impulsive features. Correlation analysis shows that obsessive-compulsivity and impulsivity scores were not correlated to skin excoriation severity symptoms. The overall viewpoints to the allocation of ED points to its own diagnostic category, that is, Body-focused Repetitive Behaviors (BFRB). Conclusion: ED shows a peculiar demographic and clinical profile. ED and OCD share more similarities in the profile of psychiatric comorbidities than GD, mostly based on anxiety disorders. In contrast, ED differs from OCD by a more frequent association with addictive disorders. ED presented intermediate levels of compulsivity and impulsivity between OCD and GD in the dimensional approach. The excoriation behavior showed no relevant correlation with dimensional measures of compulsivity or impulsivity

Repetitive Störungen manifestieren sich als Leitsymptom in der Zwangsstörung und dem Tourette-Syndrom. Die Symptome werden als enthemmte Stereotypien eines desinhibierten Basalganglien-thalamo-kortikalen (BGTC) Regelkreises verstanden. Überdies wird als neurochemisches Korrelat ein dysregulatives Dopamin (DA)-System innerhalb dieser Kerngebiete nahegelegt, welches über ein überaktives Dopamintransporter (DAT)-System erklärt werden könnte. In der Induktion repetitiver Erkrankungen ist die Interaktion des BGTC Regelkreises und des DA-Systems dennoch unklar. In der vorliegenden Arbeit wurden daher anhand von zwei Pathologiemodellen (Ratte) mit unterschiedlich induzierter Dysregulation des DA-Systems (transgen versus pharmakologisch) die dysfunktionalen Einheiten im BGTC Regelkreises vergleichend untersucht. Im transgenen Modell führte die zentralnervöse DAT-Überexpression: (1) zu einer verstärkten Genexpression des vesikulären Monoamintransporter 2 (VMAT2) sowie des DA-Rezeptors 1 und DA–Rezeptors 2 (DRD1, DRD2), (2) zu einem reduzierten DA-Spiegel mit erhöhter DA-Umsatzrate und veränderten serotonergen- und GABAergen-System, und (3) zu perserverativen Verhalten. Im Gegensatz dazu zeigte die chronische Applikation mit dem D2-Agonisten Quinpirol im pharmakologischen Modell: (1) eine Reduktion des DAT, VMAT2 und DRD2, (2) eine reduzierte DA-Umsatzrate und (3) zwanghaftes Kontrollverhalten. Die Ergebnisse legen nahe, dass die unterschiedlichen klinischen Subtypen der Zwangsstörung unterschiedlichen neurobiologischen Veränderungen zugrunde liegen könnten. Ferner bietet das hier vorgestellte transgene Modell erfolgsversprechende Ansatzpunkte um als neues valides Tiermodell der repetitiven Störungen etabliert zu werden. / Repetitive disorders manifest as the cardinal symptom in obsessive-compulsive disorder and Tourette syndrome. The symptoms are understood as disinhibited stereotypies of a basal ganglia-thalamo-cortical (BGTC) circuit. Furthermore, it is suggested that a dysregulated dopamine (DA) system within this circuit is the underlying neurochemical correlate which could be explained by an overactive dopamine transporter (DAT). At this point, it is still unclear how the BGTC circuit and the DA system interact in the induction of repetitive disorders. Therefore we investigated the dysfunctional unities within the BGTC circuit by comparing two pathological rat models (transgenic versus pharmacologic) with different induced dopaminergic dysregulation. The DAT overexpressing rat model showed: (1) increased gene expression of the vesicular monoamine transporter 2 (VMAT2), DA receptor D1 (DRD1) and DA receptor D2 (DRD2), (2) lower levels of DA with an increased DA metabolism and alterations in the serotonin- and GABA system, and (3) perseverative behavior. In contrast, the chronic application of the D2 receptor agonist quinpirole resulted in the pharmacologic model in: (1) lower gene expressions of the DAT, VMAT2 and DRD2, (2) reduced DA-turnover and (3) compulsive control behavior. These results suggest that different clinical subtypes of obsessive-compulsive disorder caused by different neurobiological alterations. In addition, the presented transgenic model provides the opportunity to be established as a new valid animal model of repetitive disorders.

Das aktuelle Modell zur Pathophysiologie der Zwangserkrankung (OCD) geht von fronto-striatalen Dysfunktionen aus. Damit werden Beeinträchtigungen im prozeduralen Lernen, das anhand der Serial Reaction Time Task (SRTT) erfasst werden kann, in Verbindung gebracht. Die Befunde zu Defiziten von OCD-Patienten in der SRTT sind widersprüchlich, was auf Unterschiede im methodischen Vorgehen sowie die zusätzliche Auslastung des Arbeitsgedächtnisses durch die Vorgabe einer Gedächtnisaufgabe zurückgeführt wird. Weiterhin ist unklar, ob die vermutete fronto-striatale Dysfunktion und die Defizite im prozeduralen Lernen kennzeichnend für OCD sind oder auch bei anderen Störungsbildern auftreten. Die prozedurale Lernleistung von OCD-Patienten wurde mit der Lernleistung von gesunden Probanden, Patienten mit einer Angststörung und Patienten mit einer Depression verglichen. Weiterhin wurde die prozedurale Lernleistung unter der Vorgabe der SRTT alleine (single-task) und bei gleichzeitiger Vorgabe einer Gedächtnisaufgabe (dual-task) untersucht. OCD-Patienten zeigten im Vergleich zu gesunden Probanden Defizite im prozeduralen Lernen – sowohl unter der single-task als auch unter der dual-task Bedingung. Im Vergleich zu Patienten mit einer Angststörung zeigte sich lediglich in der dual-task Bedingung eine tendenzielle Beeinträchtigung der OCD-Patienten. Keine Unterschiede ergaben sich in der prozeduralen Lernleistung zwischen OCD-Patienten und Patienten mit einer Depression. Die stärkste Beeinträchtigung der prozeduralen Lernleistung in den verschiedenen Symptomdimensionen (Kontrolle, Waschen, Symmetrie, Horten) der OCD zeigte sich in der Dimension Horten. Außerdem waren die Defizite im prozeduralen Lernen stärker bei Patienten mit einem früheren Beginn der Zwangsstörung ausgeprägt. Die Befunde stehen im Einklang mit bisherigen Ergebnissen, wonach bei OCD eine Beeinträchtigung im prozeduralen Lernen vorliegt, was für die Annahme einer fronto-striatalen Dysfunktion bei OCD spricht. / Obsessive-compulsive disorder (OCD) is seen as a disease that implicates fronto-striatal dysfunctions. These dysfunctions are hypothesized to be related to neuropsychological deficits. One of the putative deficits regards procedural learning, which can be assessed by using the serial reaction time task (SRTT). So far, the results regarding procedural learning in OCD patients are inconsistent, which is attributed to differences in methods, like the implementation of a secondary task (dual-task condition) using a concurrent working memory load. Moreover, it is still uncertain whether the fronto-striatal dysfunctions and the deficits in procedural learning are specific to OCD or if they can also be found in other mental illnesses. Procedural learning performance as measured with the SRTT was compared in OCD patients, healthy subjects, patients with anxiety disorder and depression. Additionally, procedural learning was examined under single- (SRTT) and dual-task (SRTT plus a secondary task) conditions. In comparison with healthy subjects, procedural learning was impaired in OCD patients – both in the single- and in the dual-task condition. Yet in the dual task condition, procedural learning was diminished in both groups. Compared to patients with anxiety disorder, OCD patients were impaired in procedural learning only in the dual-task condition, while there was no difference between OCD and depression in procedural learning. Regarding the different symptom dimensions of OCD (checking, washing, symmetry, hoarding), patients high on the dimension hoarding exhibited the most distinct impairment. Moreover, deficits in procedural learning were more pronounced in OCD patients with an earlier age at illness onset. The results confirm previous findings and add supportive evidence for performance deficits in procedural learning and the fronto-striatal dysfunction model of OCD.

Introdução: O Transtorno de Escoriação (TE) é caracterizado pelo comportamento repetitivo e excessivo de escoriar a pele saudável, resultando em dano tecidual e significativo sofrimento, associado a ânsia incontrolável e falha em controlar tal comportamento repetitivo. Atualmente o TE é classificado na seção de transtornos relacionados aos Transtornos Obsessivo-compulsivos (TOC) da 5ª edição do Manual de Diagnóstico e Estatística de Transtornos Mentais (DSM). No entanto, ainda existem debates a respeito da sua classificação, se o mesmo está relacionado a transtornos relacionados ao TOC, ou se é melhor conceituado como uma dependência comportamental. Objetivos: O presente estudo comparou um grupo de indivíduos com TE com dois paradigmas dos transtornos obsessivo-compulsivos, i.e., TOC, e dos transtornos impulsivo-aditivos, i.e., Transtorno do Jogo (TJ), analisando suas características sociodemográficas, clínicas, categorias diagnósticas, perfil de comorbidades, sintomas obsessivo-compulsivos, traços impulsivos e atributos de personalidade. O objetivo de tal comparação foi avaliar se o TE estaria mais relacionado aos transtornos relacionados ao TOC ou ao TJ. Métodos: Participaram do estudo 121 pacientes, que procuraram o tratamento no Instituto de Psiquiatria (IPq) do Hospital das Clínicas da Faculdade de Medicina da Universidade São Paulo (HCFMUSP), Brasil. Do total de 121 participantes, 40 foram diagnosticados com TE, 41 com TOC e 40 com TJ. Foram utilizadas entrevistas clínicas estruturadas para diagnosticar e comparar os três grupos na sobreposição diagnóstica e nas comorbidades psiquiátricas atuais, e escalas de autopreenchimento padronizadas para avaliar os sintomas dimensionais e comparar os três grupos em análise dimensional. Resultados: O grupo TE apresentou maior preponderância de mulheres, mais jovens e com maior instrução acadêmica. Na análise categorial TE se aproximou, significativamente, mais de TOC (n = 14) do que de TJ (n = 3), se sobrepondo ao primeiro. Os grupos TE e TOC também foram mais propensos a apresentar outros Comportamentos Repetitivos Focados no Corpo (CRFC) e transtornos ansiosos em geral. A presença de CRFC diferenciou TE de TJ, por outro lado, TE se diferenciou de TOC pela presença de comportamentos aditivos. A análise dimensional demonstrou que TE se apresenta como um modelo híbrido de obsessividade-compulsividade e impulsividade. Finalmente, a análise de correlação mostrou que os escores de obsessividade-compulsividade e impulsividade não foram correlacionados à gravidade dos sintomas de escoriação da pele. Discussão: Os dados da análise categorial apoiam a classificação de TE como um transtorno correlato ao TOC. Já os achados das análises dimensionais sugerem que uma apresentação psicopatológica híbrida de TE, contendo tanto elementos obsessivo-compulsivos, como com traços impulsivos. No entanto, nenhum desses aspectos foram correlacionados à gravidade dos sintomas de escoriação no grupo TE, sugerindo que o comportamento de escoriação da pele é independente desses fatores nestes indivíduos. O conjunto de tal apresentação sucinta a alocação de TE junto ao grupo dos chamados CRFC. Conclusão: TE apresenta um perfil demográfico e clínico próprios. TE e TOC compartilham mais similaridades no perfil de comorbidades psiquiátricas do que TJ, a maioria baseada nos transtornos ansiosos. Por outro lado, TE se diferencia de TOC, por uma associação mais frequente com os transtornos aditivos. TE apresentou níveis intermediários de compulsividade e impulsividade na abordagem dimensional. O comportamento de escoriação não mostrou correlação relevante com as medidas dimensionais de compulsividade nem impulsividade. TE, de uma forma geral, teve uma associação robusta com os outros CRFC, diferenciando-se de TOC e de TJ. TE poderia ser classificado em uma sessão à parte juntamente com outros CRFC / Introduction: Excoriation Disorder (ED) is characterized by repetitive and excessive picking on healthy skin, resulting in significant skin damage and psychological distress associated with uncontrollable urge and failure to control this repetitive behavior. ED is currently classified under the Obsessive-compulsive and Related Disorders (OCRD) section of the Diagnostic and Statistics Manual of Mental Disorders - 5th edition. Nevertheless, there is still no consensus whether ED is more closely related to OCRDs or it would be better conceptualized as a behavioral addiction. Objectives: Compare ED patients with two paradigms of obsessive-compulsive disorders (OCD) and impulsive-addictive disorders (gambling disorder), analyzing their sociodemographic and clinical characteristics, diagnostic categories, comorbidity profile, obsessive-compulsive symptoms, impulsive traits, and personality features. The purpose of this comparison was to assess whether ED was more related to OCD-related disorders (OCDRD) or to behavioral addictions, e.g., Gambling Disorder (GD). Methods: Study participants were 121 patients seeking treatment at Instituto de Psiquiatria (IPq), Hospital das Clinicas da Faculdade de Medicina da Universidade Sao Paulo (HCFMUSP), Sao Paulo, Brasil. Of the 121 participants, 40 were diagnosed with ED, 41 with OCD, and 40 with GD. Structured clinical interviews were used to diagnose and compare the three groups in diagnostic overlap and current psychiatric-comorbidities, and standardized self-reports were used to evaluate the dimensional variables. Results: Participants in the ED group were more likely to be women, young, and with higher levels of education compared with those of the other groups. In the categorical analysis, ED was more significantly approached to OCD (n=14) than to GD (n=3), overlapping the first. In general, ED and OCD were also more likely to exhibit other body-focused repetitive behaviors (BFRB) and anxiety disorders. The presence of BFRB differentiated ED from GD. In contrast, ED differed from OCD by the presence of addictive behaviors. The dimensional analysis found that ED is a hybrid model of obsessive-compulsivity and impulsivity. Discussion: Categorical analysis supports the classification of ED as OCDRD; however, ED presented differences that may share underlying characteristics with OCD (e.g., compulsivity) and behavioral addiction (e.g., impulsivity). Dimensional analysis suggests a heterogeneous psychopathological in ED with both obsessive-compulsive and impulsive features. Correlation analysis shows that obsessive-compulsivity and impulsivity scores were not correlated to skin excoriation severity symptoms. The overall viewpoints to the allocation of ED points to its own diagnostic category, that is, Body-focused Repetitive Behaviors (BFRB). Conclusion: ED shows a peculiar demographic and clinical profile. ED and OCD share more similarities in the profile of psychiatric comorbidities than GD, mostly based on anxiety disorders. In contrast, ED differs from OCD by a more frequent association with addictive disorders. ED presented intermediate levels of compulsivity and impulsivity between OCD and GD in the dimensional approach. The excoriation behavior showed no relevant correlation with dimensional measures of compulsivity or impulsivity