Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-07-04T12:09:26Z No. of bitstreams: 1 HertaJanineBatistaCosta_DISSERT.pdf: 1722649 bytes, checksum: f76b6d868dbd593d399a9e5f9130e4d3 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-07-11T14:43:49Z (GMT) No. of bitstreams: 1 HertaJanineBatistaCosta_DISSERT.pdf: 1722649 bytes, checksum: f76b6d868dbd593d399a9e5f9130e4d3 (MD5) / Made available in DSpace on 2017-07-11T14:43:49Z (GMT). No. of bitstreams: 1 HertaJanineBatistaCosta_DISSERT.pdf: 1722649 bytes, checksum: f76b6d868dbd593d399a9e5f9130e4d3 (MD5) Previous issue date: 2017-02-23 / Introdu??o: O Acidente Vascular Cerebral (AVC) ? a principal causa de incapacidade a longo prazo no mundo resultando em defici?ncias sensoriomotoras que comprometem a funcionalidade dos indiv?duos nas Atividades de Vida Di?ria (AVD?s). Assim, tecnologias de realidade virtual veem sendo cada vez mais usadas visando ? reabilita??o motora. No entanto, h? poucas evid?ncias de que os movimentos realizados em ambientes virtuais se assemelhem aos realizados em ambientes f?sicos. Objetivo: Analisar os componentes cinem?ticos do membro superior em pacientes com AVC durante um jogo de dardos em ambientes virtual e real. Metodologia: Estudo quase experimental, com amostra de 11 hemipar?ticos cr?nicos, com idade entre 40-65 anos, tempo de les?o de seis meses a tr?s anos. O ambiente virtual foi apresentado no XBOX 360 Kinect e o ambiente real usou um jogo de dardo profissional. Os participantes realizaram 15 tentativas de cada jogo e a cinem?tica do membro superior foi registrada em v?deo para an?lise no Software Kinovea. Os ambientes foram comparados usando o teste t-Student pareado. Resultados: Houve diferen?a significativa entre os ambientes virtual e real. O jogo real apresentou maior ?ngulo de extens?o de cotovelo (p=0,008), maior flex?o de ombro (p=0,008) e maior velocidade m?dia da trajet?ria do ombro (p=0,001), cotovelo (p=0,0001) e punho (p=0,001). Quantos aos picos de velocidade e acelera??o, valores m?ximos foram encontrados no jogo real para velocidade de ombro (p=0,04), cotovelo (p=0,002) e punho (p=0,002) e acelera??o de cotovelo (p=0,004) e punho (p=0,028). As velocidades de flex?o e extens?o foram maiores no jogo real para ombro (p=0,021), cotovelo (p=0,004; p=0,005) e punho (p=0,009; p=0,039). O jogo virtual obteve maior tempo de flex?o (p=0,0001) e extens?o (p=0,021) e maior desempenho (p<0,0001). Conclus?es: O jogo de dardo pode ser empregado na reabilita??o do membro superior ap?s AVC de acordo com os objetivos que a terapia quer atingir. Se for para aumentar a amplitude de movimento, velocidade e acelera??o o jogo de dardo real ? mais indicado. O jogo virtual pode contribuir para a precis?o do movimento, controle dos graus de liberdade e ajustes posturais, porque necessita de menor tempo para realiza??o do movimento. / Introduction: Stroke is the leading cause of long-term disability worldwide resulting in sensorimotor impairments that compromise functionality of individuals in Activities of daily living (ADLs). Thus, virtual reality technologies have been used increasingly aimed at motor rehabilitation. However, there is little evidence that the movements performed in virtual environments are similar to those made in physical environments. Objective: Analyze kinematics components of the upper limb in stroke patients during a game of darts in virtual and real environment. Methodology: The quasi-experimental study with a sample of 11 chronic hemiparesis, aged 40-65 years, time injury of six months to three years. The virtual environment was presented at the XBOX 360 Kinect? and the real environment used a professional dart game. Participants performed 15 trials of each game and the kinematics of the upper limb was recorded on video for analysis in Kinovea Software. The environments were compared using the t-Student test. Results: There were significant differences between the virtual and real environments. The real game showed higher elbow extension angle (p = 0.008), greater shoulder flexion (p = 0.008) and a higher mean speed of the shoulder (p = 0.001), elbow (p = 0.0001) and wrist (p = 0.001) path. As to velocity and acceleration peaks, maximum values were found in the real game shoulder (p = 0.04), elbow (p = 0.002) and wrist (p = 0.002) velocity, and elbow (p = 0.004) and wrist (p = 0.028) acceleration. The flexion and extension speeds were higher in the real game shoulder (p = 0.021), elbow (p = 0.004; p = 0.005) and wrist (p = 0.009; p = 0.039). The virtual game got longer flexion (p = 0.0001) and extension (p = 0.021) and a higher performance (p <0.0001). Conclusions: The dart game can be used in rehabilitation of the upper limb after stroke according to the goals that the therapy wants to achieve. If it is to increase the range of motion, speed and acceleration, the actual dart game is more indicated. The virtual game can contribute to the accuracy of movement, control of degrees of freedom and postural adjustments, because it requires less time to perform the movement.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-10-04T19:29:15Z No. of bitstreams: 1 WguineumaPereiraAvelinoCardoso_DISSERT.pdf: 3264434 bytes, checksum: ced67dd2365a0f817c41c18c2171f9e4 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-10-10T00:13:50Z (GMT) No. of bitstreams: 1 WguineumaPereiraAvelinoCardoso_DISSERT.pdf: 3264434 bytes, checksum: ced67dd2365a0f817c41c18c2171f9e4 (MD5) / Made available in DSpace on 2017-10-10T00:13:50Z (GMT). No. of bitstreams: 1 WguineumaPereiraAvelinoCardoso_DISSERT.pdf: 3264434 bytes, checksum: ced67dd2365a0f817c41c18c2171f9e4 (MD5) Previous issue date: 2017-07-21 / No Brasil, no final da segunda metade do s?culo XX, pesquisas em Educa??o Matem?tica (EM) despontaram em v?rios Programas de P?s-Gradua??o. No estado do Rio grande do Norte (RN) n?o foi diferente, uma vez que a Universidade Federal do Rio Grande do Norte (UFRN) possui Programas de P?s-Gradua??o que contemplam pesquisas nessa ?rea, a saber: o Programa de P?s-Gradua??o em Educa??o (PPGED), vinculado ao Centro de Educa??o (CE) e o Programa de P?s-Gradua??o em Ensino de Ci?ncias Naturais e Matem?tica (PPGECNM), vinculado ao Centro de Ci?ncias Exatas e da Terra (CCET). Neste contexto, elaboramos nossa quest?o-foco: Como iniciou e se consolidou a pesquisa em Educa??o Matem?tica, no Estado do RN? Para responder a esta quest?o, tra?amos como objetivo geral fazer uma descri??o historiogr?fica, no per?odo de 1995 a 2015, dos modos de institui??o e consolida??o de pesquisas em Educa??o Matem?tica presentes nos dois Programas citados. Isto posto, essa pesquisa se justifica pelo fato de, em 1995, ser criada no PPGED a Linha de Pesquisa intitulada Educa??o Matem?tica e, em 2002, desde a cria??o do PPGECNM, ter Linhas de Pesquisas que contemplavam pesquisas nessa ?rea. Para configurar esta pesquisa historiogr?fica, utilizamos a Hist?ria Cultural e as novas tend?ncias metodol?gicas da escrita da hist?ria, entendendo que esta se volta ao estudo da dimens?o cultural de uma determinada sociedade historicamente localizada (BURKE, 2011). Nossas fontes de pesquisa foram os documentos institucionais dos referidos Programas, esses vistos ? luz da teoria de Le Goff (2003), bem como os depoimentos dos professores que foram os percursores nas pesquisas em Educa??o Matem?tica na UFRN. Esses depoimentos foram colhidos por meio de entrevistas semiestruturadas (LAVILLE; DIONNE, 1999), realizadas com eles, que, inclusive autorizaram, por meio de uma carta de cess?o, a divulga??o de seus verdadeiros nomes. Al?m disso, por estarmos em um Programa de um Mestrado Profissional, produzimos um v?deo, atrelado a nossa quest?o-foco, como Produto Educacional, que tem por objetivo informar e motivar os professores da Educa??o B?sica e graduandos da licenciatura em Matem?tica, quando formados, a lan?arem m?o de uma forma??o continuada, agregando a sua forma??o inicial melhorias salariais, culturais, sociais, entre outras, assim como fizeram os egressos do PPGED, da ?rea de EM. Ap?s an?lise e triangula??o das fontes (ALBUQUERQUE J?NIOR, 2007) vimos que no PPGED e no PPGECNM h? pesquisas que se voltam para a EM e percebemos que em cada um deles houve uma forma singular do desenvolvimento dessas. Vimos tamb?m que, no PPGED, a Linha EM foi inserida pela Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) na estrutura do Programa em fun??o da exist?ncia dos projetos de pesquisa que estavam sendo desenvolvidos pelo ent?o professor do PPGED, PhD John Andrew Fossa. As contribui??es deste professor ajudaram significativamente na cria??o da Linha EM, como tamb?m ampliaram novas possibilidades de pesquisas em Educa??o Matem?tica no RN, conforme podemos visualizar a partir de uma ?rvore geneal?gica (MENDES, 2015a) que constru?mos, mostrando alguns egressos, orientandos do professor John Andrew Fossa e de outros professores contratados pelo Departamento de Matem?tica da UFRN, que tamb?m contribu?ram de forma significativa para o avan?o na pesquisa na ?rea de EM. Nossas an?lises tamb?m mostraram que, atualmente, h? egressos do PPGED que d?o continuidade ?s pesquisas na ?rea de EM no ?mbito da UFRN. Por fim, ao contarmos essa hist?ria, esperamos ter contribu?do para o entendimento do percurso, da constitui??o e da consolida??o da pesquisa em Educa??o Matem?tica no RN. / In Brazil, at the end of the second half of the twentieth century, research in Educa??o Matem?tica - EM (Mathematics Education) emerged in several Post-Graduate Programs.In the state of Rio Grande do Norte (RN) it was not different, since the Universidade Federal do Rio Grande do Norte - UFRN (Federal University of Rio Grande do Norte) has post-graduate programs that contemplate research in this area, namely: the Programa de P?s-Gradua??o em Educa??o - PPGED (Post-graduate Program in Education), linked to the Centro de Educa??o - CE (Education Center) and the Programa de P?s-Gradua??o em Ensino de Ci?ncias Naturais e Matem?tica - PPGECNM (Post-graduate Program in Teaching Natural Sciences and Mathematics), linked to the Centro de Ci?ncias Exatas e da Terra - CCET (Center of Exact and Earth Sciences). In this context, we elaborated our question-focus: How did the research in Educa??o Matem?tica (Mathematics Education) start and consolidate in the State of RN? In order to answer this question, we have as general objective to make a historiographical description, from 1995 to 2015, of the ways of institution and consolidation of research in Educa??o Matem?tica (Mathematics Education) present in the two Programs mentioned. Therefore, this research is justified by the fact that in 1995 the Research Line was created in PPGED entitled Educa??o Matem?tica (Mathematics Education) and in 2002, since the creation of the PPGECNM, there were lines of research that included research in this area. To configure this historical research, we used the cultural history and new methodological trends in history writing, understanding that this is about the study of the cultural dimension of a certain historically located society (BURKE, 2011). Our sources of research were the institutional documents of these Programs, those seen in the light of Le Goff's theory (2003), as well as the statements of the professors who were the forerunners of research in Educa??o Matem?tica (Mathematics Education) at UFRN. These statements were collected through semi-structured interviews (LAVILLE; DIONNE, 1999) with them, including authorizing, through a letter of assignment, a disclosure of their real names. In addition, because we are in a Program of a Professional Master's Degree, we produced a video, linked to our question-focus, as Produto Educacional (Educational Product), which aims to inform and motivate Basic Education teachers and undergraduate students in Mathematics, when graduated, to take on a continuous formation, adding to their initial formation salary, cultural and social improvements, among others, as did the graduates of PPGED, From the EM area. After analyzing and triangulating the sources (ALBUQUERQUE J?NIOR, 2007), we have seen that in PPGED and PPGECNM there are researches that turn to EM and we noticed that in each of them there was a unique form of the development of these. We also saw that in the PPGED, the EM Line was inserted by the Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior ? CAPES (Coordination for the Improvement of Higher Education Personnel) in the structure of the Program due to the existence of the research projects being developed by the PPGED professor, PhD John Andrew Fossa. The contributions of this professor helped significantly in the creation of the EM Line, but also expanded new possibilities of research in Mathematics Education in the RN, as we can see from a genealogical tree (MENDES, 2015a) that we built, showing some graduates of the master's degree, masters orientated by Professor John Andrew Fossa and other professors hired by the Departamento de Matem?tica da UFRN (Department of Mathematics of UFRN), who also contributed significantly to the advancement in research in the field of EM. Our analyzes also showed that, currently, there are graduates of the PPGED who continue the researches in the area of EM within the UFRN. Finally, as we tell this story, we hope to have contributed to the understanding of the course, constitution and consolidation of the research in Educa??o Matem?tica (Mathematics Education) in the RN.

Made available in DSpace on 2014-12-17T15:48:13Z (GMT). No. of bitstreams: 1 LaurindoSBN.pdf: 1520391 bytes, checksum: 86f5072a56e661766a5174bce88b82d5 (MD5) Previous issue date: 2007-09-21 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico / Non-Photorealisitc Rendering (NPR) is a class of techniques that aims to reproduce artistic techniques, trying to express feelings and moods on the rendered scenes, giving an aspect of that they had been made "by hand". Another way of defining NPR is that it is the processing of scenes, images or videos into artwork, generating scenes, images or videos that can have the visual appeal of pieces of art, expressing the visual and emotional characteristics of artistic styles. This dissertation presents a new method of NPR for stylization of images and videos, based on a typical artistic expression of the Northeast region of Brazil, that uses colored sand to compose landscape images on the inner surface of glass bottles. This method is comprised by one technique for generating 2D procedural textures of sand, and two techniques that mimic effects created by the artists using their tools. It also presents a method for generating 21 2D animations in sandbox from the stylized video. The temporal coherence within these stylized videos can be enforced on individual objects with the aid of a video segmentation algorithm. The present techniques in this work were used on stylization of synthetic and real videos, something close to impossible to be produced by artist in real life / Renderiza??o N?o Fotoreal?stica (NPR) ? uma classe de t?cnicas que almejam reproduzir t?cnicas art?sticas, tentado expressar sentimentos e emo??es nas cenas renderizadas, dando um aspecto de que foram feitas "manualmente". Outra forma de definir a NPR ? como o processamento de cenas, imagens ou v?deos para gera??o de trabalhos de arte, gerando cenas, imagens ou v?deos que podem ter o atrativo visual de pe?as art?sticas, expressando caracter?sticas visuais e emocionais do estilo art?stico. Esta disserta??o apresenta um novo m?todo de NPR para estiliza??o de imagens e v?deos baseado em uma express?o art?stica t?pica da regi?o Nordeste do Brasil, que usa areia colorida para compor imagens de paisagens na superf?cie interna de garrafas de vidro. Este m?todo possui uma t?cnica para gera??o de texturas procedurais de areia 2D, e duas t?cnicas que imitam os efeitos criados pelos artes?es usando sua ferramenta. Al?m disso, essa disserta??o apresenta tamb?m um m?todo para gera??o de anima??es 21 2D em caixas de areia a partir do v?deo estilizado. A coer?ncia temporal nos v?deos estilizados pode ser for?ada nos objetos individuais do v?deo com aux?lio de um algoritmo de segmenta??o de v?deo. As t?cnicas apresentadas neste trabalho s?o usadas na estiliza??o de v?deos reais e sint?ticos, algo quase imposs?vel de ser produzido pelo artes?o na vida real

Submitted by PPG Pediatria e Sa?de da Crian?a (pediatria-pg@pucrs.br) on 2018-02-16T19:08:17Z No. of bitstreams: 1 Tese Vers?o Final Tiago Fazolo 18_01_2018.pdf: 3827531 bytes, checksum: b081e8333d16cb49ba00d0df25dff485 (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2018-02-22T17:20:04Z (GMT) No. of bitstreams: 1 Tese Vers?o Final Tiago Fazolo 18_01_2018.pdf: 3827531 bytes, checksum: b081e8333d16cb49ba00d0df25dff485 (MD5) / Made available in DSpace on 2018-02-22T17:35:15Z (GMT). No. of bitstreams: 1 Tese Vers?o Final Tiago Fazolo 18_01_2018.pdf: 3827531 bytes, checksum: b081e8333d16cb49ba00d0df25dff485 (MD5) Previous issue date: 2017-03-20 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Respiratory syncytial virus (RSV) is the most common etiologic agent in severe lower respiratory tract infections (LRTI) in children. RSV-associated LRTI is the main cause of bronchiolitis, pneumonia and exacerbation of asthma. This infection is responsible for the high rates of hospitalizations related to respiratory diseases worldwide, especially in children younger than 2 years. Currently, annual mortality rate due to RSV infections is worrying worldwide and is estimated at approximately two hundred thousand cases. The treatment strategies to RSV infections are limited. Ribavirin is an approved drug for use in RSV infections, but its use is limited due to adverse side-effects and risks posed to health professionals who handle it. Palivizumab is a monoclonal antibody which targets RSV F glycoprotein and its use is only indicated as a prophylactic measure. This treatment is already accepted in several countries for groups of high risk children (premature children, with chronic lung disease and with congenital heart disease). However, palivizumab has a high cost for public health and is not available in all countries. The development of an effective RSV vaccine to generate a long-lasting immunological memory response that prevents infection may be the best alternative because it will reduce high public health expenditures with antiviral drugs and monoclonal antibodies. The first attempt in the search for a vaccine against RSV was in the 1960s. This vaccine produced high levels of serum antibodies but could not protect against infection. Children who were vaccinated developed a more serious disease when later infected with the same virus. To date, there is no licensed vaccine for RSV, so the search for effective vaccines is an important focus of research. Natural RSV infections do not induce lasting protective memory, and multiple reinfections can occur lifetime. Nasal secretions from infected infants presented a small number of regulatory CD4 T cells (Treg) in peripheral blood, an increase in interleukin 4 (IL-4) production and T helper type 2 (Th2) response. Treg cells are important for controlling an exacerbated increase in immune responses. A reduction of the Tregs caused by the RSV infection generates an exacerbation of the pulmonary disease due to a Th2 response. The M209-223 RSV peptide was identified to increase IFN-? production by peptide-specific CD4 T cells after challenge with the virus. The treatment with this peptide also induced an increase in pulmonary Treg frequency in infected mice. Recently, it has also been shown that Tregs aid in the development of a T CD8+ effector response, which is crucial for the control of RSV viral load. Our hypothesis is that the RSV M209-223 peptide impacts in the differentiation of CD4 T cells, increasing the population of specific Treg, reducing lung inflammation and modulating the anti-RSV immune response. This peptide in animal model induces the differentiation of specific Treg. Our findings suggest that vaccination with M209-223 peptide results in the differentiation of specific CD4 T cells into conventional effectors and Treg cells. Vaccination with this peptide decreased the expansion of a Th2 response in animals infected with RSV, protecting both the infection site and systemically. We believe that this approach could be an important component in vaccination strategies against this virus. / O v?rus sincicial respirat?rio (VSR) ? o agente etiol?gico mais comum nas infec??es graves do trato respirat?rio inferior (TRI) em crian?as. As infec??es do TRI associada com o VSR s?o a principal causa de bronquiolite, pneumonia e exacerba??o da asma. As TRI causadas pelo VSR s?o respons?veis pelas altas taxas das hospitaliza??es relacionadas ?s doen?as respirat?rias em todo o mundo, principalmente em crian?as menores de dois anos. Atualmente a taxa de mortalidade anual mundial devido ?s infec??es pelo VSR ? preocupante e ? estimada em aproximadamente duzentas mil crian?as. As estrat?gias de tratamento contra o VSR utilizadas s?o limitadas. A ribavirina ? um f?rmaco aprovado no uso para infec??es pelo VSR, por?m sua utiliza??o ? limitada devido aos efeitos secund?rios adversos e aos riscos que representam para os profissionais da sa?de que o manipulam. O palivizumabe ? um anticorpo monoclonal dirigido contra a glicoprote?na F do v?rus e sua utiliza??o ? apenas como medida profil?tica. Este tratamento j? ? aceito em v?rios pa?ses nos grupos de crian?as de alto risco (crian?as prematuras, com doen?a pulmonar cr?nica e com cardiopatia cong?nita). Entretanto o palivizumabe tem um alto custo para sa?de p?blica, n?o sendo disponibilizado em todos os pa?ses. O desenvolvimento de uma vacina eficaz contra o VSR pode ser a melhor alternativa, pois ao gerar resposta de mem?ria duradoura que previne a infec??o e reduz, desta forma, os altos gastos com a sa?de p?blica, com os f?rmacos antivirais e com os anticorpos monoclonais. A primeira tentativa na busca de uma vacina contra o VSR foi na d?cada de 60. A vacina produzida estimulou n?veis moderadamente elevados de anticorpos no soro, mas n?o conseguiu proteger contra ? infec??o. As crian?as que foram vacinadas desenvolveram uma doen?a mais grave quando mais tarde infectados com o v?rus. At? o presente momento n?o existe nenhuma vacina licenciada para o VSR. Desta forma, a busca de vacinas eficazes constitui um importante foco de pesquisa em todo mundo. As infec??es naturais pelo VSR n?o induzem mem?ria protetora duradoura, ocorrendo m?ltiplas reinfec??es ao longo da vida. Em crian?as infectadas, observou-se um n?mero reduzido de c?lulas T CD4+ regulat?rias (Treg) no sangue perif?rico, um aumento na produ??o de interleucina 4 (IL-4) e uma resposta T helper do tipo 2 (Th2) nas secre??es nasais. As c?lulas Treg s?o importantes para controlar um aumento exagerado da resposta imunol?gica. Por este fato acredita-se que quando h? uma redu??o das Tregs causada pela infec??o do VSR ocorre uma exacerba??o da doen?a pulmonar devido uma resposta Th2. Foi identificado que o pept?deo M209-223 do VSR aumenta a produ??o de IFN-? nas c?lulas T CD4+ ap?s o desafio com VSR. O tratamento com este mesmo pept?deo tamb?m apresentou um aumento na frequencia de c?lulas Treg ap?s infec??o prim?ria pelo VSR. Recentemente tamb?m foi demonstrado que as Tregs auxiliam no desenvolvimento de uma resposta efetora T CD8+, que ? crucial para o controle da carga viral do VSR. Nossa hip?tese ? que o pept?deo M209-223 do VSR influencia na diferencia??o das c?lulas T CD4+, aumentando a popula??o de c?lulas T efetoras e regulat?rias espec?ficas, reduzindo a inflama??o pulmonar e modulando a resposta imune. Os nossos resultados sugerem que a vacina??o com pept?deo M209-223 resulta na diferencia??o de c?lulas T CD4+ espec?ficas em efetoras convencionais, que produzem mais IFN-? e em c?lulas Treg. A vacina??o com este pept?deo diminuiu a expans?o de uma resposta Th2 nos animais infectados com o VSR, protegendo da inflama??o exacerbada tanto no local da infec??o como sistemicamente. Acreditamos que esta abordagem pode constituir um componente importante nas estrat?gias de vacina??o contra este v?rus.

Made available in DSpace on 2014-12-17T15:32:28Z (GMT). No. of bitstreams: 1 Tese_GeorgeJFN.pdf: 2720479 bytes, checksum: 6d72db8b12a0e5f743d69a67430d66b7 (MD5) Previous issue date: 2010-02-18 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico / Matrix metalloproteinase-7 (MMP-7) and -9 (MMP-9) modulate important functions strictly related to the development, invasion and metastasis of several human cancers among them the squamous cell carcinoma of the tongue (SCCT). However, individual genetic factors such as the functional single nucleotide polymorphisms (SNPs) influence the pattern of protein expression of these MMPs and thus may be related to the variability observed in the clinical behavior of patients with SCCT. In this context, the present cross-sectional study aimed to evaluate the association between the frequency of the functional SNPs MMP-7 -181 A/G and MMP-9 -1562 C/T and the clinical (age, gender and metastasis) and pathological (malignancy histological grading and immunohistochemistry expression) features of SCCT cases. Genotyping of these SNPs were performed by PCR-RFLP on DNA samples from 71 cases of SCCT and 60 individuals without cancer who constitute the control group. Among the results of this research, it was observed that the frequency of the polymorphic alleles MMP-7 -181 G and MMP-9 -1562 T in SCCT patients was 28% and 12%, respectively, and the frequency of the heterozygotes A/G (PR = 2.00; p < 0.001) and C/T (PR = 1.54; p = 0.014) were significantly higher in the patient group than in the controls. The prevalence of patients carrying the combination of SNPs studied was significantly associated with SCCT cases (PR = 2.00; p = 0.011) and metastasis (PR = 2.00; p < 0.001). Furthermore, with the frequency of SNPs analyzed, the age, gender, histological grading and immunoreactivity of MMP-7 and MMP-9 formed clinical and pathological parameters relevant to the identification of population subgroups more related to the development of SCCT and metastasis. Based on these results, it is suggested that the protein expression levels of MMP-7 and -9 substantially influence the balance between their pro- and anticancer biological functions and hence the clinicopathological profile of the squamous cell carcinoma of the tongue / As metaloproteinases da matriz extracelular-7 (MMP-7) e -9 (MMP-9) modulam importantes fun??es relacionadas ao desenvolvimento, invas?o e met?stase de diversos c?nceres humanos, dentre os quais o carcinoma epiderm?ide de l?ngua (CEL). Entretanto, fatores gen?ticos individuais, tais como polimorfismos de nucleot?deo ?nico (SNPs) funcionais, influenciam no padr?o de express?o proteica dessas MMPs, podendo estar relacionados ? variabilidade no comportamento cl?nico tumoral observado em pacientes com CEL. Neste contexto, o presente trabalho objetivou, atrav?s de an?lise em sec??o transversal, estudar a associa??o entre a frequ?ncia dos SNPs funcionais MMP-7 -181 A/G e MMP-9 -1562 C/T e as caracter?sticas cl?nicas (idade, sexo e met?stase) e patol?gicas (grada??o histol?gica e express?o imuno-histoqu?mica) em uma s?rie de casos de CEL. A genotipagem dos referidos SNPs foi executada por PCR-RFLP em amostras de DNA de 71 casos de CEL e de 60 indiv?duos sem c?ncer, que constitu?ram o grupo controle. Dentre os resultados da presente pesquisa, evidenciou-se que a frequ?ncia dos alelos polim?rficos MMP-7 -181 G e MMP-9 -1562 T nos pacientes com CEL foi de 28% e 12%, respectivamente, sendo as frequ?ncias dos heterozigotos A/G (RP = 2.00; p < 0.001) e C/T (RP = 1.54; p = 0.014) significativamente maiores neste grupo de pacientes que no grupo controle. A preval?ncia dos pacientes portadores da combina??o dos SNPs estudados associou-se significativamente aos casos de CEL (RP = 2.00; p = 0.011) e ? met?stase (RP = 2.00; p < 0.001). Ademais, junto ? frequ?ncia dos SNPs analisados, a idade, sexo, grada??o histol?gica e imunoexpress?o da MMP-7 e -9 constitu?ram par?metros clinicopatol?gicos relevantes para a identifica??o de subgrupos populacionais mais predispostos ao desenvolvimento do CEL e met?stase. Frente a estes resultados, sugere-se que os n?veis de express?o da MMP-7 e -9 influenciam consideravelmente no balan?o entre suas fun??es pr? e antineopl?sicas e, consequentemente, no perfil clinicopatol?gico do carcinoma epiderm?ide de l?ngua.

This study explores how contemporary Afrikaans churches represent gender in their visual culture. For these purposes, a Barthean semiotic analysis is done on visual material produced between 2007 and 2008 by three Afrikaans corporate churches in the Pretoria- Centurion area, namely the Dutch Reformed congregations Moreletapark and kerksondermure (“church without walls”), and Doxa Deo’s Brooklyn and East campuses – Afrikaans Apostolic Faith Mission congregations. The analysis seeks to demystify and denaturalise the material’s potentially mythical, ideological and hegemonic underpinnings. Operating from an interdisciplinary theoretical framework comprising aspects of Visual Culture Studies and Gender Studies, this study primarily provides a focused analysis of the representation of men and masculinity in the selected churches according to three themes, namely professional occupation and leadership; physical activity and adventurism; and fatherhood. This focus was adopted owing to the lack of available literature on men and masculinity in the church and Christianity, as opposed to the more ready availability of research on women and femininity. The representation of gender in Moreletapark, kerksondermure and Doxa Deo is conceptualised in broad terms through a comparison of the representation of masculinity with femininity as its foil. In this regard gender is analysed in the three churches according to notions of gendered ontology and matters of work, marriage and family. Exscripted, or non-represented, themes are also problematised. It is argued that the churches under investigation represent gender in dualistic, essentialist and often stereotypical terms. This particular depiction of gender attests to the churches‟ participation in the biological essentialising of gender, polarising men and women into strict binary dualisms, whilst also visually denying the existence of homosexuality and alternative sexualities. This tendency is problematic, not only because it fails to provide a realistic portrayal of men and women in the three churches, but also because it visually participates in conservative and fundamentalist gender discourses. / Dissertation (MA)--University of Pretoria, 2013. / Visual Arts / unrestricted

Submitted by PPG Comunica??o Social (famecos-pg@pucrs.br) on 2018-04-24T10:42:22Z No. of bitstreams: 1 RAFAEL_ROSINATO_VALLES_TES.pdf: 4997803 bytes, checksum: 305c1c0d476913fdfc9c6514f3196432 (MD5) / Approved for entry into archive by Sheila Dias (sheila.dias@pucrs.br) on 2018-05-07T18:51:24Z (GMT) No. of bitstreams: 1 RAFAEL_ROSINATO_VALLES_TES.pdf: 4997803 bytes, checksum: 305c1c0d476913fdfc9c6514f3196432 (MD5) / Made available in DSpace on 2018-05-07T19:29:39Z (GMT). No. of bitstreams: 1 RAFAEL_ROSINATO_VALLES_TES.pdf: 4997803 bytes, checksum: 305c1c0d476913fdfc9c6514f3196432 (MD5) Previous issue date: 2018-03-19 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / This thesis carries out a study of the diary in the work of Jonas Mekas, throughout three formats: the written diary, the diary-film and the video diary. The aim is to analyze how Mekas?s work contributes to an understanding of the diary as a narrative form, and how the author constructs his process of self-representation by means of the diaries. This work seeks to establish a definition for the diary, by means of theoretical references related to the spheres of literature (Braud, 2006; Simonet-Tenant, 2004; Girard, 1986; Lejeune, 2015; Blanchot, 2005) and of audiovisual work (James, 2013; Renov, 1996). As object of study, we analyze the book I had nowhere to go (1991), the diary-films Lost Lost Lost (1976), Walden ? Diaries, Sketches & Notes (1969), Reminiscences of a Journey to Lithuania (1972), and video diaries from the 365 Day Project (2007). This thesis takes weavings (Daney, 2007; Benjamin, 1994) and rends (Daney, 2007; Didi-Huberman, 2014, 2015) as its methodology, grounding itself on the way in which Mekas elaborates his narrative choices and his historical condition. We conclude that Mekas?s work points to an understanding of the diary not solely as literary genre, but as a narrative that affirms itself in a plurality of forms, following the shifts done by the author in his relation to time, space, and the use of different technical devices. We also conclude that Mekas, in his diaries, builds an intrinsic relation between narrating the lived and living the narrated, which reveals how the diaries not only document a certain socio-historical context, but are also themselves part of that context and of the subjectivity built by their author. / Esta tese realiza um estudo sobre o di?rio, que aparece na obra do cineasta Jonas Mekas em tr?s formatos: o di?rio escrito, o filme-di?rio e o v?deo-di?rio. O objetivo ? analisar como essa obra contribui para um entendimento sobre o di?rio enquanto forma narrativa e como o autor constr?i o seu processo de autorrepresenta??o por meio dos di?rios. Este trabalho procura construir uma defini??o de di?rio, a partir de referenciais te?ricos relacionados ao ?mbito liter?rio (Braud, 2006; Simonet-Tenant, 2004; Girard, 1986; Lejeune, 2015; Blanchot, 2005) e audiovisual (James, 2013; Renov, 1996). Como objetos de estudo, s?o analisados o livro I had nowhere to go (1991), os filmes-di?rio Lost Lost Lost (1976), Walden ? Diaries, Sketches & Notes (1969), Reminisc?ncias de uma viagem para a Litu?nia (1972) e os v?deos-di?rio pertencentes a 365 Day Project (2007). Esta tese assume como metodologia os conceitos de teceduras (Daney, 2007; Benjamin, 1994) e rasgaduras (Daney, 2007; Didi-Huberman, 2014, 2015), a partir da forma como Mekas realiza as suas escolhas narrativas e apresenta a sua condi??o hist?rica. Este trabalho conclui que a obra em pauta aporta um entendimento sobre o di?rio n?o somente como um g?nero liter?rio, mas como uma narrativa que se afirma na sua pluralidade de formas, de acordo com os deslocamentos que o autor efetua na sua rela??o com o tempo, com o espa?o e com o uso de diferentes dispositivos t?cnicos. Tamb?m conclui que Mekas constr?i, nos seus di?rios, uma rela??o intr?nseca entre narrar o vivido e viver o narrado, o que revela como os registros documentam um determinado contexto s?cio-hist?rico e, ainda, como esses registros fazem parte do pr?prio contexto e da subjetividade constru?da pelo seu autor.

Une question demeure récurrente : les divisions qui subsistent depuis le XVIè siècle entre Catholiques, Luthériens et Réformés sont-elles autant d’ordre anthropologique que théologique ? Cette problématique paraissant pouvoir être soutenue, il convenait alors de déterminer les différends anthropologiques, de les analyser et de se demander s’ils sont une entrave à la Κοινωνία. L’étude de la situation au XVIè siècle a permis de conclure que les concepts anthropologiques portés par une philosophie existentielle ont joué un rôle important dans la rupture au sein de l’Église d’Occident. Le retour sur la pensée de Pannenberg, Moltmann, Rahner, théologiens de trois confessions différentes, autorise à dire qu’au XXè siècle la vision de l’homme a toujours une incidence sur les concepts théologiques, mais les différences sont de moins en moins séparatrices et deviennent souvent des dons à partager. L’analyse de dialogues œcuméniques a mis en évidence que les différends anthropothéologiques ont été partiellement réconciliés et font l’objet d’accords, voire d’une déclaration commune sur la Doctrine de la Justification. Aujourd’hui, un défi reste à relever celui d’une déclaration sur le Ministère en vue du partage à la même table eucharistique. Une démarche de consensus différencié serait une aide à la recherche d’une pleine communion. / An issue has been ever recurring : are the discords which have been going on since sixteenth century between Catholics, Lutherans, Calvinists as much anthropological as theological ? As this question can be supported it seems suitable to determine these anthropological disagreements, analyse them and wonder whether or not they are obstacle to the Κοινωνία. A study concerning the situation during the XVIth century has allowed to conclude that the anthropological concepts conveyed by an existential philosophy have played a mojor role in the severing within the Western Church. The return on the thoughts developed by Pannenberg, Moltmann and Rahner, theologians of three different confessions, allows us to tell that in the XXth. century man’s vision has always an incidence on the theological concepts but are less and less separative and are often gifts to be shared. The analysis of ecumenical dialogues have clearly shown that theanthropological disagreements have been partly reconciled and are now subject to consensus, even a joint declaration on the doctrine of justification. Today we have to take up a challenge about a declaration on the ministry in order to share the body of Christ at the same table. A differing consensus method could be a help to find a complete communion.

<p>Кулинарска лексика уопште, као и<br />кулинарска лексика Војводине није до сада<br />детаљније са лексичко семантичког и<br />творбеног аспекта обрађивана (осим у<br />појединим приказима наших дијелектолога и<br />лексикографа), али је свакако она (не у<br />потпуности) део српских важнијих<br />дијалекатских речника (Од Вукова до<br />Речника српских говора Војводине) и<br />речника општег типа.<br />У истраживачком раду је примењена у нас<br />одомаћена теорија семантичких поља руског<br />етнолингвисте Никите Толстоја. У лексичко<br />семантичкој и творбеној анализи као и у<br />лексикографској обради примењен је<br />дескриптивни, лингвогеографски и<br />компаративни метод.<br />Обрађено је шеснаест семантичких поља:<br />Намирнице, Оброци, Припремање хране,<br />Зимница, Млеко , млечни производи и јела<br />од млека, Супе и чорбе, Јела од теста,<br />Јела од јаја, Јела од меса, Месне<br />прерађевине, Врсте меса и делови, Умаци,<br />Јела од поврћа, Колачи, слаткиши, Пића,<br />Јела приликом разних светковина.<br />Материјал је и лексикографски уобличен, а<br />потом картографисан.</p> / <p>Kulinarska leksika uopšte, kao i<br />kulinarska leksika Vojvodine nije do sada<br />detaljnije sa leksičko semantičkog i<br />tvorbenog aspekta obrađivana (osim u<br />pojedinim prikazima naših dijelektologa i<br />leksikografa), ali je svakako ona (ne u<br />potpunosti) deo srpskih važnijih<br />dijalekatskih rečnika (Od Vukova do<br />Rečnika srpskih govora Vojvodine) i<br />rečnika opšteg tipa.<br />U istraživačkom radu je primenjena u nas<br />odomaćena teorija semantičkih polja ruskog<br />etnolingviste Nikite Tolstoja. U leksičko<br />semantičkoj i tvorbenoj analizi kao i u<br />leksikografskoj obradi primenjen je<br />deskriptivni, lingvogeografski i<br />komparativni metod.<br />Obrađeno je šesnaest semantičkih polja:<br />Namirnice, Obroci, Pripremanje hrane,<br />Zimnica, Mleko , mlečni proizvodi i jela<br />od mleka, Supe i čorbe, Jela od testa,<br />Jela od jaja, Jela od mesa, Mesne<br />prerađevine, Vrste mesa i delovi, Umaci,<br />Jela od povrća, Kolači, slatkiši, Pića,<br />Jela prilikom raznih svetkovina.<br />Materijal je i leksikografski uobličen, a<br />potom kartografisan.</p> / <p>Culinary lexicon as such, as well as the<br />culinary lexicon of Vojvodina Region has so far<br />not been systematically examined in the lexicosemantic<br />and word-formation aspect (except for<br />some reviews of our dialectologists and lexicographers). However, it is (yet not</p><p>completely) a part of some major Serbian<br />dialect dictionaries (from Rječnik, a dictionary<br />by Vuk Stefanović Karadžić to Dictionary of<br />Serbian Vojvodina Speech) as well as the<br />range of general dictionaries.<br />The research implied the semantic field<br />theory developed by Russian ethno-linguist<br />Nikita Tolstoy, which is commonly applied<br />approach in our region. Lexico-semantic and<br />word-formation analysis as well as<br />lexicographic processing were performed<br />applying descriptive and linguo-geographic<br />methods.<br />Sixteen semantic fields were analyzed:<br />Foodstuffs; Meals; Food Preparation; Winter<br />Stores; Milk; Dairy Products and Dishes; Soups<br />and Stocks; Pasta and Savory Dishes; Egg<br />Dishes; Meat Dishes; Meat Products; Meat<br />Types and Cuts; Sauces; Vegetable Dishes;<br />Cakes, Cookies and Sweets; Drinks and<br />Beverages; Festive Foods. The material was<br />lexicographically edited and cartographed.</p>