Bestaande navorsing aangaande die terapeutiese intervensie met die dwelmafhanklike adolessent is beperk, veral navorsing wat fokus op die bewuswordingsproses tydens die terapeutiese intervensie. In hierdie studie is gepoog om die benuttingswaarde van Gestalthulpmiddels ten opsigte van die verhoging van bewuswording by die dwelmafhanklike adolessent, tydens die terapeutiese proses vas te stel. Die navorsingsproses is deur kwalitatiewe navorsing gering om in hierdie doel te slaag. Die navorsingsinligting is met behulp van 'n uitgebreide literatuurstudie, asook deur middel van die waarneming en bestudering van twaalf gevallestudies bekom. Die benuttingswaarde en die toepassingsmoontlikhede van die Gestalthulpmiddels binne die Gestaltterapeutiese proses met die dwelmafhanklike adolessent, is verken en beskryf. Deur middel van die prossesering en integrering van die bevindinge wat tydens die empiries ondersoek verkry is, kon die data vir praktiese doeleindes toegepas word. 'n Riglyn wat vir die verhoging van bewuswording by die dwelmafhanklike adolessent gebruik kan word is aanbeveel. SUMMARY Existing research on the therapeutic intervention with the drug-addicted adolescent is limited, especially research that focused on the awareness process during therapeutic involvement. This study attempt to determine the face value of Gestalt helping aids throughout the improved awareness of the drug-addicted adolescent during the therapeutic process. A qualitative research approach was followed to achieve this goal. The research data is gained by a detailed literature study, as well as by the observation and study of twelve case studies. The value and the possibilities of application of the Gestalt helping aids in the Gestalt therapeutic process with the drug-addicted adolescent, is examined and described. By processing and integrating the assumptions obtained during the empirical study, the data could have been practically applied. As suggested out of this study a guideline can be developed for the improvement of awareness of the drug addicted adolescent. / Social work / M.Diac (Play Therapy)

The present study explored factors affecting vulnerability to depression among gay men and lesbian women in metropolitan Gauteng, South Africa. Risk factors consistently cited in the literature on depression among gay men and lesbian women, namely self-esteem, social integration, hate speech, physical victimisation, fear of victimisation and alcohol and drug abuse, were examined to determine their ability to predict vulnerability to depression. Data was collected from 385 participants who self-identified as lesbian or gay, using a purposive quota sampling technique to ensure representation across age, gender, race and socio-economic status lines. Participants were selected through gay and lesbian organisations, support groups, counselling centres, the gay and lesbian Pride Parade, an online questionnaire, and via snowballing techniques. Multiple regression analysis indicated that self-esteem and hate speech were the only significant predictors of vulnerability to depression. The regression model accounted for 21.7% of the variance in vulnerability to depression scores. / Psychology / M. Sc. (Psychology)

Substance abuse amongst children is a major problem in South Africa and world-wide. The trend of new drugs entering the drug market has increased in South Africa. Currently in South Africa, there is a new drug on the market known as “nyaope” being abused mostly by adolescents in the Townships. The negative consequences of substance abuse affect not only individuals who abuse substances but also their parents and significant others. The researcher observed that most literature in the field of substance abuse focuses on the children addressing issues such as causes, effects, psychological impact and others. Very little is documented on parents‟ experiences and coping capabilities as well as the support they need or receive. This further contributed to the researcher‟s purpose of conduct this study to explore parents‟ experience and support needs with regard to their children‟s addiction to nyaope. / MA (Social Work)

Existem no Brasil aproximadamente 370 mil usuários de cocaína fumada nas capitais nacionais e há cerca de dez anos o uso de crack e/ou cocaína atinge quatro em cada dez adolescentes brasileiros em situação de rua, gerando diversas consequências individuais, familiares e sociais, que fazem deste fenômeno um grave problema de saúde pública. O presente estudo foi realizado em três momentos que se consubstanciaram em um capítulo de livro, um artigo de revisão e um artigo empírico. O capítulo teve como objetivo a contextualização do panorama epidemiológico do consumo de drogas na sociedade brasileira, perpassando por uma caracterização geral do termo e suas especificidades, assim como uma reflexão acerca desse fenômeno à luz da Teoria Social Cognitiva. Discute-se que a noção de reciprocidade triádica que perpassa toda a concepção sociocognitivista, vem contribuindo para uma leitura dinâmica e sistêmica do consumo de drogas, que avança para além de uma compreensão puramente individual, seja biológica ou comportamental. O artigo de revisão de literatura foi sobre o Modelo Transteórico de Mudança (MTT) e o suporte familiar no cuidado ao usuário de crack, auxiliando na discussão sobre as estratégias para o lidar com dependência química. Neste foram analisados trabalhos que discorrem sobre as contribuições do Modelo Transteórico de Mudança no tratamento do comportamento adicto e a importância do entendimento sobre os estágios motivacionais e processos de mudança pelo usuário, família e equipe técnica, exigindo a atenção dos profissionais quanto ao entendimento e tratamento dos comportamentos de risco, demandando por sua vez a reformulação de estratégias de tratamento e cuidado para usuários que se encontram em qualquer estágio. O artigo empírico que se seguiu à revisão, abordou o tema central da dissertação e objetivou investigar a influência da percepção do suporte familiar, da crença de autoeficácia e do estágio motivacional do usuário de crack na adesão ao cuidado oferecido no Programa ATITUDE. Foi um estudo misto que primeiramente investigou 60 usuários de ambos os sexos que estavam acolhidos nas modalidades de assistência: apoio e intensivo. Na segunda fase foram entrevistados cinco participantes de ambos os sexos. Foram utilizados os seguintes instrumentos: Inventário de Percepção de Suporte Familiar (IPSF); Escala de Autoeficácia Geral Percebida (AEGP); University of Rhode Island Change Assesment Scale Escala URICA e entrevista semi-estruturada. Pela extração do alpha de Chronbach foram obtidos indicadores insatisfatórios de consistência interna das escalas AEGP e URICA, e elevados para o IPSF. A discussão perpassa pelo perfil singular da amostra, já que muitos dos usuários vivem na rua, com uma multiplicidade de carências de cuidados básicos e que, mesmo apresentando algum nível de escolarização, podem ter experienciado algum nível de incompreensão no sentido do que demandava a atividade em cinco alternativas de escolha, tendendo a se posicionar com certa facilidade quando a temática foi mais concreta, como no caso da família, tendo também essa escala um número de alternativas de escolha menor que as demais. Talvez um quantitativo maior de usuários pudesse diluir essas inconsistências encontradas nas duas primeiras escalas. Por fim, as entrevistas permitiram evidenciar a importância dos vínculos familiares para uma melhor compreensão do fenômeno do uso do crack em sua multiplicidade questionando e propondo um olhar ampliado sobre a família, como importante fonte de apoio aos usuários na continuidade de seu cuidado. / There are approximately 370 thousand users of cocaine smoked in Brazil in the national capitals, and for the last ten years the use of crack and / or cocaine has reached four out of every ten Brazilian adolescents in the street, generating a number of individual, family and social consequences. Of this phenomenon is a serious public health problem. The present study was carried out in three moments that consubstantiated in a chapter of book, a review article and an empirical article. The chapter aimed to contextualize the epidemiological panorama of drug use in Brazilian society, through a general characterization of the term and its specificities, as well as a reflection on this phenomenon in the light of Cognitive Social Theory. It is argued that the notion of triadic reciprocity that permeates the entire sociocognitive conception has been contributing to a dynamic and systemic reading of drug consumption, which goes beyond a purely individual understanding, be it biological or behavioral. The literature review article was about the Transtheoric Model of Change (MTT) and the family support in crack user care, helping to discuss strategies for dealing with chemical dependency. In this paper we analyze the contributions of the Transtheoric Model of Change in the treatment of addicted behavior and the importance of understanding the motivational stages and processes of change by the user, family and technical team, demanding the professionals' attention regarding the understanding and treatment Of risky behaviors, which in turn require the reformulation of treatment and care strategies for users who are at any stage. The empirical article that followed the review, addressed the central theme of the dissertation and aimed to investigate the influence of the perception of family support, the belief of self efficacy and the motivational stage of crack users in adherence to the care offered in the ATITUDE Program. It was a mixed study that first investigated 60 users of both sexes that were hosted in the assistance modalities: support and intensive. In the second phase, five participants of both genders were interviewed. The following instruments were used: Family Support Perception Inventory (IPSF); Perceived General Self-Efficacy Scale (AEGP); University of Rhode Island Change Assesment Scale - URICA scale and semi-structured interview. By extracting the Chronbach alpha, we obtained unsatisfactory indicators of internal consistency of the AEGP and URICA scales, and high for the IPSF. The discussion is based on the unique profile of the sample, since many of the users live on the street, with a multitude of basic care deficits and, even with some level of schooling, may have experienced some level of misunderstanding in the sense of what the activity demanded In five alternatives of choice, tending to position themselves with certain ease when the theme was more concrete, as in the case of the family, also having this scale a number of alternatives of choice smaller than the others. Perhaps a larger number of users could dilute these inconsistencies found on the first two scales. Finally, the interviews allowed to highlight the importance of family ties for a better understanding of the phenomenon of crack use in its multiplicity, questioning and proposing an extended view of the family, as an important source of support to users in the continuity of their care.

Made available in DSpace on 2016-06-02T19:42:36Z (GMT). No. of bitstreams: 1 SILVA_Daniele_2015.pdf: 1362140 bytes, checksum: 4473a0058d16bc314bb735e693473640 (MD5) Previous issue date: 2015-02-26 / The main objective of this study was to analyze the conception of education that is implicit in the activities developed by the association "Pode Crer", seeking to understand them from the dialogue between Popular Education and the Health Humanization Policy. The research was conducted by one year of participant observation during which the activities developed by this Association (Drop in, Harm Reduction, Halfway House and some extra activities) were accompanied. The analysis showed several interfaces between the proposal of Harm Reduction and Popular Education on the activities developed by "Pode Crer". It could be also seen how the references used for a better understanding of this Association have a common point: the humanization. Thus, it is an important credibility work of this activity that happens in the invisibility, although with great potential to promote education for the subjects who experience many vulnerabilities from the common management, from shared responsibility, unconditional acceptance, radical listening, horizontal dialogue and aspects that promote meaningful learning at the everyday life of this people / O objetivo geral desse trabalho foi analisar a concepção de educação implícita nas atividades desenvolvidas pela Associação Pode Crer , buscando compreendê-las a partir do diálogo com a Educação Popular e com as Políticas de Humanização da Saúde. A pesquisa foi desenvolvida por meio da observação participante, a partir de um ano de acompanhamento das atividades desenvolvidas por essa Associação (Drop in, Redução de Danos, Casa de Passagem e algumas atividades extras). A análise mostrou diversas interfaces entre a proposta de Redução de Danos e Educação Popular nas atividades desenvolvidas pela Pode Crer . Também se pôde perceber como os referenciais utilizados para uma maior compreensão dessa Associação possuem um ponto comum: a humanização. Assim, trata-se de um relevante trabalho de credibilização dessa atividade que está acontecendo na invisibilidade, porém com grande potencial de promoção de educação para os sujeitos que vivenciam as mais diversas vulnerabilidades, a partir da gestão comum, da corresponsabilidade, do acolhimento incondicional, escuta radical, diálogo horizontal e diversos aspectos que favorecem aprendizagens significativas no dia a dia dessas pessoas.

Diploma work provides description of a drug scene in the region Jindřichův Hradec. It characterizes recent network of services, and presents process as well as basic models of Harm Reduction services optimalization. It also provides analysis and description of problem drug use in four towns within the region {--} it is Jindřichův Hradec, Třeboň, Dačice and a smaller town České Velenice. Next to the analysis and description of recent situation the diploma work also attempts to estimate possible development of drug scene as well as drug services in the near future.

The thesis deals with the issue of care of drug addicts in the in the Czech Republic, particularly the Harm Reduction. The theoretical part of the thesis describes the above-mentioned working procedures with clients, the legislative framework of the services and the current situation on the drug scene in the Czech Republic. The practical part uses a qualitative form of research. The information was collected by means of structured interviews with open questions. The respondents were eleven workers of contact centres in the Central Bohemian region which has five such facilities. I cooperated with four of them for the purposes of the thesis. The objective of the thesis was to demonstrate that the Harm Reduction services are important and beneficial from the viewpoint of workers of contact centres and to find out whether the contact workers have any suggestions about how to improve the Harm Reduction services in the Czech Republic.

Introdução. A doença isquêmica coronariana (DIC) ainda é a principal causa de morte no mundo. A sua prevenção secundária é essencial, uma vez que reduz novos eventos cardiovasculares e mortalidade, e pode ser influenciada por diversos fatores, incluindo sociodemográficos. Objetivo. Avaliar a prevenção secundária da doença isquêmica coronariana na linha de base do Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil) (2008-2010). Métodos. Os dados foram analisados pelos testes: Kolmogorov-Smirnov, qui-quadrado, análise de variância (ANOVA), Mann-Whitney e regressão logística, conforme necessário. Resultados. Dos 15.094 participantes, 2,7% reportaram diagnóstico prévio de DIC. Destes, 16,3% não utilizavam qualquer medicamento recomendado pelas diretrizes, 22,7% relataram utilizar a combinação de antiplaquetário, betabloqueador, antagonista do sistema renina-angiotensina e hipolipemiante, e 12,1% a combinação de antiplaquetário, betabloqueador e hipolipemiante. Os principais fatores associados ao uso de medicamento foram renda [Razão de Chances (RC) = 2,041 Intervalo de Confiança de 95% (IC95%)1,07 a 3,89] e sexo (RC = 0,517 IC95% 0,31 a 0,85). A frequência de uso dos medicamentos se manteve semelhante conforme o tempo desde o evento isquêmico coronariano, exceto para o uso de apenas um medicamento, que foi aumentando conforme o tempo. Conclusão. A prevenção secundária foi menor do que o recomendado pelas diretrizes, principalmente em mulheres e participantes com menor renda, indicando uma necessidade de melhores políticas públicas que visam a prevenção secundária de DIC / Introduction. Coronary heart disease (CHD) remains the main cause of mortality worldwide. Secondary prevention of CHD is necessary and avoids new cardiovascular events and mortality. Several factors, including sociodemographic characteristics, contribute positively or negatively to secondary prevention. Objective. To evaluate secondary prevention of CHD in the baseline examination of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods. Kolmogorov-Smirnov test, chi-squared test, one-way analysis of variance (ANOVA), Mann-Whitney test and logistic regression models were performed, as necessary. Results. Of the 15,094 participants included, 2.7% reported previous diagnosis of CHD. Not using any drug was reported by 16.3% of participants with CHD and the use of recommended drugs were reported by 22.7% for the combination of four classes and 12.1% for the combination of antiplatelet medication, beta-blocker and lipid lowering. The main characteristics associated with medication use was income [Odds Ratio (OR) = 2.041; 95% Confidence Interval (95%CI) 1.07 to 3.89] and sex (OR = 0.517; CI95% 0.31 to 0.85). Frequency of medication use was similar among time since CHD event, except for the use of just one drug that increased over time. Conclusion. Use of secondary prevention for CHD was below the recommended guidelines, especially in women and participants with lower income, suggesting the need of public health policies addressing secondary prevention of CHD, especially in these high-risk groups

Introduction: The dynamics in the development and use of drugs, as an essential part of the care process for patients with hepatitis C, requires equal dynamics in the evaluation of their use, as a way to improve the offer of patient care. Objective: To evaluate the profile of use, effectiveness and safety of medications for the treatment of hepatitis C. Materials and Methods: The thesis was divided into four chapters that sought to respond to the specific objectives of the research. To do so: 1 - a transverse review of the medical records of all patients with hepatitis C who received antiviral therapy with interferon / peginterferon and ribavirin between 2002 and 2012; 2-. The charts of all patients with hepatitis C treated with boceprevir or telaprevir in combination with peginterferon and ribavirin between the years of 2013 and 2015 were analyzed; 3 - a systematic review was conducted to assess the incidence of adverse reactions associated with pharmacotherapies; 4- the perception of a group of patients treated or under treatment with one of the therapeutic regimens for hepatitis C on the impact of adverse reactions was analyzed. Results: In article 1, 298 treatments of hepatitis C with interferon / peginterferon were analyzed, and the sustained response ranged from 40.8% to 58.3% among untreated and previously treated patients with recurrent disease. Regarding article 2, 48 treatments were analyzed that associated the use of telaprevir or boceprevir with peginterferon and ribavirin, presenting sustained response rates ranging from 61.5% associated with telaprevir to 50% to boceprevir. Response rates decreased to 22.8% with telaprevir and 15.4% with boceprevir, when considering the intentions to be treated. In article 3, 13 studies were selected that included 8,221 patients and highlighted 4,801 reports of adverse reactions with 41 different manifestations. The selection ranking shows preferences for the use of direct-acting antivirals and lower recommendation of protease inhibitors. The analysis of patient perceptions (article 4) showed that negative experiences associated with pharmacotherapy are among the main barriers in treatment. Conclusions: The largest cohort of the analyzed universes indicates that the main pharmacotherapy for hepatitis C between the years 2002 and 2015 was the association with peginterferon and ribavirin, remaining as immunomodulants and virustatics used in association with protease inhibitors. The use of combinations with boceprevir or telaprevir has not been shown to be satisfactory and should be avoided. Classical therapy with peginterferon and ribavirin should be preferred over aggregative therapy with protease inhibitors, since the reactions are more insidious and difficult to treat. Directacting antivirals are safer, although the evidence is less robust. Adverse drug reactions affect the daily and the way patients relate to disease and treatment in the perception of a group of patients. Analyzes of the results contribute to the medico-social and economic basis of regulatory activities and other decisions in the field of medication policy and treatment of hepatitis C. / Introdução: A dinâmica no desenvolvimento e uso de medicamentos, como parte essencial no processo de cuidado ao paciente com hepatite C, exige igual dinâmica na avaliação de sua utilização, como forma de melhorar a oferta de assistência ao paciente. Objetivo: Avaliar o perfil de uso, efetividade e segurança dos medicamentos para o tratamento da hepatite C. Materiais e Métodos: A tese foi dividida em quatro capítulos que buscaram responder aos objetivos específicos da pesquisa. Para tanto: 1- foi realizada uma revisão transversal dos prontuários de todos os pacientes com hepatite C que receberam terapia antiviral com interferon/peginterferon e ribavirina entre os anos de 2002 e 2012; 2-. foram analisados os prontuários de todos os pacientes com hepatite C, tratados com boceprevir ou telaprevir em associação com peginterferon e ribavirina, entre os anos de 2013 a 2015; 3- uma revisão sistemática foi realizada a fim de avaliar a incidência de reações adversas associadas às farmacoterapias; 4- analisou-se a percepção de um grupo de pacientes tratados ou em tratamento com um dos esquemas terapêuticos para hepatite C sobre o impacto das reações adversas. Resultados: no artigo 1 foram analisados 298 tratamentos da hepatite C com interferon/peginterferon, sendo que a resposta sustentada variou de 40,8% a 58,3% entre os pacientes não tratados e previamente tratados com doença recorrente. Quanto ao artigo 2 foram analisados 48 tratamentos que associaram o uso do telaprevir ou boceprevir com peginterferon e ribavirina, apresentando taxas de resposta sustentada que variaram de 61,5% associados ao telaprevir e 50% ao boceprevir. As taxas de resposta diminuíram para 22,8% com telaprevir e 15,4% com boceprevir, quando consideradas as intenções em tratar. No artigo 3 foram selecionados 13 estudos que incluíram 8.221 pacientes e destacaram 4.801 relatos de reações adversas com 41 manifestações diferentes. O ranking de seleção mostra preferências para o uso de antivirais de ação direta e menor recomendação dos inibidores de protease. A análise das percepções de pacientes (artigo 4) mostraram que as experiências negativas associadas à farmacoterapia estão entre as principais barreiras no tratamento. Conclusões: a maior coorte dos universos analisados indica que a principal farmacoterapia para hepatite C entre os anos de 2002 a 2015 foi a associação com peginterferon e ribavirina, permanecendo como imunomodualdores e virustáticos usados em associação com os inibidores de proteases. A utilização das associações com boceprevir ou telaprevir não se mostraram satisfatórias e devem ser evitadas. A terapia clássica com peginterferon e ribavirina deve ser preferida em relação à terapia agregativa com inibidores de protease, uma vez que nestas, as reações são mais insidiosas e de difícil manejo. Os antivirais de ação direta são mais seguros, embora as evidências sejam menos robustas. As reações adversas provocadas pelos medicamentos afetam o cotidiano e a maneira como os pacientes se relacionam com a doença e o tratamento, na percepção de um grupo de pacientes. As análises dos resultados contribuem para a base médico-social e econômica das atividades de regulamentação e outras decisões no campo da política de medicamentos e tratamento da hepatite C.

Submitted by Erika Demachki (erikademachki@gmail.com) on 2017-07-07T17:29:02Z No. of bitstreams: 2 Dissertação - Sandra Hernandez Morais de Araújo - 2017.pdf: 3596744 bytes, checksum: 396468c02a05d61bf35172317ac7f3d7 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-07-10T14:45:10Z (GMT) No. of bitstreams: 2 Dissertação - Sandra Hernandez Morais de Araújo - 2017.pdf: 3596744 bytes, checksum: 396468c02a05d61bf35172317ac7f3d7 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Made available in DSpace on 2017-07-10T14:45:10Z (GMT). No. of bitstreams: 2 Dissertação - Sandra Hernandez Morais de Araújo - 2017.pdf: 3596744 bytes, checksum: 396468c02a05d61bf35172317ac7f3d7 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2017-05-30 / Introduction: The use of Psychoactive Substances (PS) brings problems in several areas of the subject's life such as: health, psychological and social. Epidemiological studies show that it is in the passage from childhood to adolescence that the use begins. In Brazil, the treatment is preferentially done in the Centers of Psychosocial Care and in them are offered psychosocial and pharmacological interventions and the combination of them. Pharmacological interventions can be used to stabilize, detoxify, ameliorate withdrawal symptoms and prevent relapse. The pharmacist plays an important role in the safe and effective use of medicines in children and adolescents, since it can prevent identifying, evaluating and intervening in problems related to pharmacotherapy. Objective: to analyze the use of drugs by users of the Psychosocial Care Center Alcohol and Drugs Infanto Juvenil 24 hours (CPCAD adi III). Methodology: an analytical and quantitative cross-sectional study, carried out by reviewing medical records. The medical records of users who were younger than 18 years of age and with prescription of medicines were included and the medical records that were not filled out were excluded. Potential drug interactions (PDI) were analyzed using the Micromedex® and Medscape® database. Descriptive and bi-and multivariate logistic regression analyzes were performed considering a statistically significant relationship p≤0.5. Results: Of the 159 records used in the study, 71.7% were male subjects with mean age of 16 ± 1.9 years, incomplete elementary schooling (88%) and the search for treatment occurred in 55, 3% by judicial measure. Among the diagnostic hypotheses, the most frequent were mental and behavioral disorders due to the use of multiple drugs and the use of other psychoactive substances (F19) 34.9% and mental and behavioral disorders associated with the use of cannabinoids (F12) With 17.2%. The age of first use of SP was on average 12.4 ± 1.90 years. The most used PS was Cannabis (37.2%). The most prescribed drugs were the N03A (antiepileptic) 39.94% and N05A (antipsychotic) 34.83%% groups. A total of 815 PDI were found per type of interaction, 352 drugcannabis, 139 drug-ethanol, 125 drug-foods, 99 drug-tobacco, 83 drug-drug, and 17 drug-cocaine. Regarding the severity of the PDI found, 59.4% were moderate, 23.8% were secondary, 15.7% were serious and 1.1% were contraindicated. The drugs that presented the most PDI were chlorpromazine (32.3%) and diazepam (19.6%). Conclusion: the adolescents were the majority of males, the diagnostic hypothesis that had the highest frequency was that of mental and behavioral disorder due to the use of SPA (F-19). The use of PS was on average at 12 years of age and the most consumed PS was marijuana. The most commonly prescribed drugs were valproic acid (30.63%) and chlorpromazine (20.72%). It was found of 815 PDI with 59.4% classified as moderate. The factor involved in polypharmacy was total PDI and among the factors involved in the occurrence of total PDI were: being studying and the amount of diagnostic hypothesis. In view of the high PDI index, the relationship with polypharmacy and a high number of diagnostic hypotheses, it is necessary to increase the attention of health professionals regarding the topic and the development of protocols to support decision making. / Introdução: o uso de Substâncias Psicoativas (SPA) acarretam problemas em diversas áreas da vida do sujeito tais como: na saúde, psicológicos e sociais. Estudos epidemiológicos mostram que é na passagem da infância para a adolescência que se inicia o uso. No Brasil, o tratamento é feito preferencialmente nos Centros de Atenção Psicossocial e neles são ofertadas intervenções psicossociais e farmacológicas e a combinação delas. As intervenções farmacológicas podem ser utilizadas para estabilizar, desintoxicar, melhora dos sintomas de abstinência e evitar recaídas. O farmacêutico exerce papel importante na utilização segura e eficaz de medicamentos em crianças e adolescentes, pois o mesmo pode prevenir identificar, avaliar e intervir nos problemas relacionados à farmacoterapia. Objetivo: analisar a utilização de medicamentos por usuários do Centro de Atenção Psicossocial Álcool e Drogas Infanto Juvenil 24 horas (CAPS adi III). Metodologia: estudo transversal analítico e quantitativo, realizado por meio da revisão de prontuários. Foram incluídos os prontuários dos usuários que eram menores de 18 anos de idades e com prescrição de medicamentos e foram excluídos os prontuários que não estavam devidamente preenchidos. As potenciais interações medicamentosas (PIM) foram analisadas por meio do banco de dados Micromedex® e Medscape®. Foram realizadas análises descritivas e de regressão logística bi e multivariada considerando relação estatística significante p≤0,5. Resultados: dos 159 prontuários utilizados no estudo, 71,7% eram sujeitos do sexo masculino com a média de idade de 16 ± 1,9 anos, escolaridade ensino fundamental incompleto (88%) e a busca pelo tratamento deu-se em 55,3% por medida judicial. Dentre as hipóteses diagnósticas, as que apresentaram maior proporção foram os transtornos mentais e comportamentais decorrentes do uso de múltiplas drogas e do uso de outras substâncias psicoativas (F19) 34,9% e transtornos mentais e comportamentais associados com o uso de canabinóides (F12) com 17,2%. A idade do primeiro uso de SPA foi em média de 12,4 ±1,90 anos. A SPA mais utilizada foi a Cannabis (37,2%). Os medicamentos mais prescritos foram os grupos N03A (antiepilépticos) 39,94% e N05A (antipsicóticos) 34,83%%. Foram encontradas 815 PIM e por tipo de interação, foram encontradas 352 medicamento-cannabis, 139 medicamento-etanol, 125 medicamentoalimento, 99 medicamento-tabaco, 83 medicamento-medicamento e 17 medicamento-cocaína. Em relação a gravidade das PIM encontradas foram 59,4% moderadas, 23,8% secundárias, 15,7% graves e 1,1% contraindicado. Os medicamentos que mais apresentaram as PIM foram a clorpromazina (32,3%) e o diazepam (19,6 %). Conclusão: os adolescentes eram a maioria do sexo masculino, a hipótese diagnóstica que teve a maior frequência foi a de transtorno mental e comportamental devido ao uso de SPA (F-19). O uso de SPA foi em média aos 12 anos de idade e a SPA mais consumida foi a maconha. Os medicamentos mais prescritos foram: ácido valpróico (30,63%) e clorpromazina (20,72%). Encontrou-se de 815 PIM com 59,4% classificadas como moderada. O fator envolvido na polifarmácia foi o total de PIM e dentre os fatores envolvidos na ocorrência do total PIM, foram: estar estudando e a quantidade de hipóteses diagnóstica. Diante do alto índice de PIM, a relação com polifarmácia e alto número de hipóteses diagnósticas, faz-se necessário maior atenção dos profissionais de saúde quanto ao tema e desenvolvimento de protocolos para suporte na tomada de decisão.