Blood flow and its payload of molecular oxygen are two parameters of most physiological interest. Systemic tissue health is routinely gauged through measurements of vitals and oxygen saturation to estimate the state of these physiological parameters. We design, develop, and deploy optical imaging systems for examining perfusion and oxygenation at the local tissue level and apply these techniques for elucidating the normal and pathological processes associated with neurovascular disease. Specifically, we develop and validate the ability to use Multi-Exposure Speckle Imaging (MESI) to estimate microvascular flow dynamics in rodents over acute and chronic periods. Next, we pose significant optimizations to improve the efficacy of the widefield imaging technique for adoption by bench-side and clinical perfusion studies. We also introduce re-interpretations of the underlying physics to advance the theory that quantifies motion from the imaged speckle patterns. Finally, the technique is deployed for chronic monitoring of cortical flow dynamics before after focal ischemia of the motor cortex as part of a behavioral study in rodents. At the microscale, we develop and validate Two Photon Phosphorescence Lifetime Microscopy (2PLM) to examine dissolved oxygen concentration in microvasculature in three dimensions. We examine the technique’s ability for functional mapping of the rodent cortical microvascular network by quantifying the partial pressure of oxygen (pO₂) before and after occlusion of critical arterioles. Automation of acquisitions and processing for robust oxygen mapping within the micro-vascular network are developed and evaluated. The in vivo results are presented in light of those from studies utilizing more invasive mapping electrodes to provide independent corroboration of the observed neurovascular oxygen distributions. The technique is deployed for examining high resolution functional and structural remodeling after focal cerebral ischemia. / text

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Bakgrund: Inom vården hanteras dagligen stora mängder material och det är av stor vikt att rätt material är på rätt plats, i rätt tid, i rätt mängd och med rätt kvalitet för att en så god vård som möjligt ska kunna erbjudas. För att säkerställa effektiva och välfungerande gods- och informationsflöden med hög servicenivå inom vården, krävs det förståelse för hur flödena fungerar, hur dessa är relaterade till varandra samt hur de samverkar. Det är en stor fördel för en organisation att kartlägga sina flöden då man genom en kartläggning kan identifiera kvalitetsbrister samt orsakerna till dessa och därefter vidta förbättringsåtgärder som resulterar i kvalitetsökningar. Syfte: Detta examensarbete avser att göra en nulägesbeskrivning med hjälp av flödekartläggningar av regionservice godsflöde och informationsflöde av förbrukningsmaterial. Syftet är att identifiera de nuvarande kvalitetsbristerna och orsakerna till dessa samt föreslå åtgärder som ska leda till förbättringar. Metod: Denna fallstudie har utgått från en kvalitativ undersökningsdesign där data har samlats in genom ostrukturerade intervjuer, semistrukturerade intervjuer samt deltagande observationer. För att möjliggöra identifieringar av kvalitetsbrister och de bakomliggande orsakerna till dessa upprättades flödeskartläggningar respektive orsak-verkandiagram som har legat till grund för förbättringsåtgärderna. Slutsatser: I studien framgår det att majoriteten av kvalitetsbristerna som uppstår i flödet av förbrukningsmaterial beror på att det saknas ett aktivt informationsutbyte mellan aktörerna, att rätt förutsättningar och utrustningar för spårning av godset inte finns tillgängligt samt att kvalitetskontroller inte genomförs. Utifrån dessa bakomliggande orsaker har tre åtgärder som tillsammans utgör grunden till ett bra logistikflöde och skapar förutsättningar för mer3 (106)effektiva och välfungerande gods- och informationsflöden föreslagits. För att regionservice ska kunna ha kontroll över flödet av förbrukningsmaterial och erhålla en högre kvalitet krävs det att de implementerar ett godsspårningssystem som kommer kunna säkerställa denna kvalitet genom att felen som uppstår i flödet snabbt kan spåras och åtgärdas. Godsspårningssystemet bör sedan kompletteras av ett informationssystem som skapar förutsättningar för en god kommunikation och informationstillgänglighet som på så sätt kan effektivisera informationsflödet och stärka samarbetet mellan de involverade aktörerna. Genom att kvalitetskontroller genomförs regelbundet i hela flödet kan även fel och brister upptäckas och minimeras. / Background: A large amounts of material is handled on a daily basis in health care and it is of great importance that the right material is at the right place at the right time, in the right quantity and the right quality in order to be able to offer as good care as possible. In order to ensure efficient and functional flows of goods and flows of information with a high level of service, it requires an understanding of how the flows operate, how they are related to each other and how they interact. It is beneficial for an organization to map their flows since it can help identify quality deficiencies and their causes and thereafter take improvement measures that increases the quality. Purpose: This thesis intends to describe the present situation through a flow mapping of the flow of materials of consumption in Regionservice. The aim is to identify existing quality deficiencies and their causes to thereafter be able to recommend measures that will result in improvements. Method: This case study is based on a qualitative research design where data were collected through unstructured interviews, semi-structured interviews and participating observations. In order to enable identifications of quality deficiencies and the underlying causes of these, flow mappings and cause-effect diagrams were established and have been the basis of the improvement measures. Conclusions: This study indicates that the majority of the quality defeiciencies that occur in the flow of materials of consumption is due to the lack of an active exchange of information between the actors, the right conditions and equipments for tracking the goods and that quality controls are not implemented. Based on these underlying causes there are three measures that have been suggested that together form the foundation for an optimal logistics 5 (106) and creates conditions for more efficient and functional flows of goods and information. In order for Regionservice to be able to control the flow of materials of consumption and obtain a higher quality, they are required to implement a tracking system that will ensure this quality since the deficincies that occur in the flow can be tracked and fixed. The tracking system should be complemented by an information system that creates oppurtunites for good communication and information accessibility which will enhance the cooperation between the actors involved. By conducting quality controls regularly throughout the flow, faults and deficiencies can be discovered and minimized.

Every type of current meter is different and has its proper characteristics. Knowing the performance of a current meter is essential in order to use it properly either for field or laboratory measurements (such as in the Offshore Technology Research Center wave basin). A study of the MAVS (Modular Acoustic Velocity Sensor) in a wave basin is a first step essential for later deployment in real studies. This thesis is based on data obtained from different series of laboratory measurements conducted in the OTRC wave basin. The objective of the first part of the study was to characterize the MAVS frequency response using benchmarks such as tow tests or wave tests. These benchmarks allowed us not only to characterize the sensor but also to eventually correct some of the measurement distortions due to flow blockage, vortex shedding, or vibrations of the mounting structure, for example. After the preliminary study was done, we focused on the potential use of the MAVS in the OTRC wave basin. Indeed, in the case of a study of a scale model in the wave basin, the stresses applied to the model have to be accurately known. In the case of current-induced loads, this includes contributions from both the mean flow and the turbulence. Thus, after correcting the values measured by the MAVS, a mapping of the current jet was executed to determine its three-dimensional structure in the wave basin. Knowing the structure of the current in the OTRC wave basin, it was then possible to define a domain in which the current can be considered uniform with a certain tolerable error. This domain of uniformity will allow us to validate the use of the OTRC wave basin to study large models such as FPSOs (Floating Production, Storage and Offloading Units).

Detta examensarbete har genomförts på Mape Sweden AB med syfte att eliminera eller minska icke värdeskapande aktiviteter inom inköpsprocessen. Genom att undersöka hur fö-retaget arbetar med inköp och dess inköpsaktiviteter för verktyg och reservdelar är målet att hitta lösningar som innebär en tidseffektivisering av inköpsprocessen. Arbetet är av kvalitativ karaktär. Denna ansats valdes då gruppen ville få en förståelse över nuläget genom kvalitativa metoder. Metoderna som använts för att samla in data till arbetet var observationer och intervjuer, en litteraturstudie samt benchmarking på ett annat tillver-kande företag. För att ta fram förbättringsförslag till företaget utfördes ett spagettidiagram över förflyttningar. En tidsstudie genomfördes för att kunna jämföra tiderna innan och efter implementering av förbättringsförslagen. Vid analysen av nuläget framkom att olika typer av inköp görs av olika personer på företaget, vilket resulterar i att det inte finns ett standardiserat arbetssätt. Spagettidiagrammet över för-flyttningar vid godsuttag och godsmottagning visade att många förflyttningar görs och att ett stort antal av dem är onödiga. Genom denna information samt den information som erhållits från benchmarkingen tog gruppen fram förbättringsförslag. Förbättringsförslaget innebär för godsuttag att operatörerna själva skriver in sina uttag i affärssystemet SAP. För godsmottag-ningen var förbättringsförslagen att endast göra godsmottagning en gång per dag, att placera en hylla för ej lagerlagda verktyg och en hylla för förnödenheter i verktygsboden samt att ställa krav på leverantörerna att alltid ha med artikelnummer och lagerplats på följesedeln som medföljer alla leveranser. Vid införande av förbättringsförslagen kommer den totala tiden som läggs på godsuttag och godsmottagning minska från 6 timmar, 40 minuter och 23 sekunder till 1 timma och 58 mi-nuter, vilket motsvarar en minskning av tiden på 70 %. I framtiden rekommenderas att förbättringsförslagen även implementeras på andra typer av inköp inom företaget samt att företaget vidare undersöker fördelarna med verktygsskåp och skanningssystem. / This Bachelor's Thesis has been performed at Mape Sweden AB with the purpose of elimi-nate or reduce the non-value adding activities within the purchasing process. By examining the company's purchasing process for tools and spare parts, the goal is to find solutions that will entail time-efficiency in the purchasing process. The work in this thesis is of qualitative nature. This approach was chosen to obtain an un-derstanding of the current situation with qualitative methods. To collect data the group per-formed several observations and interviews, literature reviews and a benchmarking at a dif-ferent manufacturing company. To develop proposals for improvements to the company, a spaghetti diagram was conducted tracking all movements at goods-withdrawal and goods-receipt. A time study was conducted to compare the times before and after implementation of improvement proposals. The current situation analysis showed that purchases are made by different people resulting in that there is not a standardized approach. Spaghetti diagram of movements in goods-withdrawal and goods-receipt showed that there is numerous movements and some of them are unnecessary. Proposals for improvements was conducted based on the information from current situation analysis together with information obtained from benchmarking. The pro-posal for goods-withdrawal was that the workers themselves enter goods-withdrawal in the SAP-system. The proposals for goods-reception was to receive the goods once a day, place a shelf for non-stocked tools and a shelf for supplies in the tool shed as well as making demands on suppliers to always have the part number and stock location on the packing slip included with all deliveries. .When implementing the groups proposed improvements, the total time spent on goods-receiving and goods-withdrawal was reduced from 6 hours, 40 minutes and 23 seconds to 1 hour and 58 minutes, which represents a decrease of 70%. For future work the group recommend that the improvement proposals also be implemented on other types of purchases within the company and that the company further investigate the benefits of tool cabinet and scan-ning systems.

International aviation regulations on emissions are becoming more strict. Improvements goals on fuel efficiency demand development of technologies capable of reducing fuel consumption and gas emissions. Morphing structures capability to adapt their aerodynamic shape for optimal condition in flight brings potential for reduction of aircraft drag and operating fuel consumption, minimizing gas emissions and fuel expenses. This study presents an investigation on the impact of a camber morphing winglet on midsize business jet using numerical simulation and wind tunnel experiments. A genetic algorithm was used to optimize the winglet sections camber for different flight conditions. Optimized geometries achieved total drag reduction of up to 0.58% compared to original winglet for single condition optimization, reaching up to 7 % reduction on consumed fuel on a typical mission. This efficiency improvement allows aircraft to carry 900 kg additional load, comprising the morphing system and extra payload. There is an indication of even better results for applications on a bigger commercial jet. Presented methodology is also suitable for new winglet fixed geometry design or incorporating morphing technology. Aerodynamic balance force measurements showed that optimized winglets increased the wing effective aspect ratio (AReff), reducing the lift-induced drag, and maximum lift coefficient (CLmax). However, maximum lift to drag ratio (L/Dmax) was reduced on CL optimization region due to flow differences between optimization and wind tunnel conditions. Aerodynamic efficiency improvement was found for greater lift coefficients (CL). Reductions on wing tip vortex size and intensity due to winglet installation are seen on measured vorticity map, showing liftinduced drag reduction according to Maskells equation. Parabolic drag polar and Maskells equation methods were used for lift-induced drag calculation, using balance force and flowing mapping data for calculations. The presented concept showed considerable aircraft performance improvement, using a feasible device with greater certification ease than other morphing structures concepts, once the failure of this system would not compromise flight safety. Further investigation using computational fluid dynamics (CFD) and wind tunnel experiments is necessary to develop and test a functional camber morphing winglet device. / Regulamentações internacionais sobre emissões estão se tornando mais rigorosas. Metas de melhoria da eficiência de consumo de combustível demandam o desenvolvimento de tecnologias capazes de reduzir o consumo e emissões de gases. Estruturas capazes de adaptar sua forma aerodinâmica para condição ótima em voo trazem potencial de redução do arrasto e consumo de combustível da aeronave, minimizando as emissões de gases e gastos com combustível. Este estudo apresenta uma investigação sobre o impacto de uma winglet de camber variável em um jato executivo da categoria mid size utilizando simulação numérica e experimentos em túnel de vento. Um algoritmo genético foi usado para otimizar o camber das seções para diferentes fases de voo. As geometrias otimizadas reduziram o arrasto total em até 0.58% comparadas a winglet original na otimização de condição única, alcançando até 7% de redução no combustível consumido em missão típica. Essa melhoria de eficiência permite a aeronave carregar 900 kg de carga adicional, composta pelo sistema de adaptação e carga paga extra. Há uma indicação de resultados ainda melhores para aplicação em um jato comercial maior. A metodologia apresentada é apropriada para projeto de uma nova winglet de geometria fixa ou que incorpore a tecnologia de adaptação. Medidas de força com balança aerodinâmica mostraram que as winglets otimizadas aumentaram o alongamento efetivo da asa (AReff), reduzindo o arrasto induzido, e o coeficiente de sustentação máximo (CLmax). No entanto, a máxima razão entre sustentação e arrasto (L/Dmax) foi reduzida dentro do intervalo de CL da otimização devido as diferenças entre as condições do escoamento na otimização e no túnel de vento. Melhoria na eficiência aerodinâmica foi obtida para coeficientes de sustentação (CL) maiores. Reduções no tamanho e intensidade do vórtice de ponta de asa são vistas nos mapas de vorticidade medidos, mostrando redução do arrasto induzido segundo a equação de Maskell. Os métodos da polar de arrasto parabólica e da equação de Maskell foram usados para o cálculo do arrasto induzido, utilizando nos cálculos os dados de força da balança e o mapeamento do escoamento. O conceito apresentado mostrou melhoria considerável no desempenho da aeronave, utilizando um sistema factível e com maior facilidade para certificação que outros conceitos de estruturas adaptáveis, uma vez que a falha desse sistema não comprometeria a segurança do voo. Mais estudos são necessários para desenvolver e testar uma winglet de camber varável funcional.

Much research regarding efficiency in manufacturing industry has historically been focused on the material activities of the shop floor. However, companies that merely focus on material activities when trying to improve lead times, risk losing potential for improvements within immaterial activities such as planning, engineering, design, and purchasing, which often constitute the most time consuming parts of the order fulfillment processes. Engineer to order (ETO) products are particularly time consuming regarding their immaterial activities, and the customer is waiting for the products from the very beginning of the order fulfillment process. Shortening the lead time to customer for ETO products is therefore important for customer satisfaction. The aim of this study is to adapt an existing lead time tree model currently focused on material activities to also include immaterial activities, enabling a full visualization of all activities contained in order fulfillment processes. The lead time tree model would thereby be able to use as a tool when working on shortening the lead time to customer. A further aim of the study is to investigate how the adapted lead time tree model can be used in further areas as well, in addition to visualizing immaterial activities. The adaption of the lead time tree model has been based on the original literary source of the lead time tree model. The original lead time tree model has been analyzed towards theoretical data from a literature study, and towards empirical data about immaterial activities in order fulfillment processes for ETO products, from the case company Kongsberg Maritime Sweden AB (previously Rolls-Royce AB). The result of this has been an adapted lead time tree model that can visualize immaterial activities. Several adaptions of the original lead time tree model have been made for it to be able to visualize immaterial activities, while still keeping the basics of the original model. The adapted lead time tree model comprises information that is normally kept separated and that is important when planning and improving a process. Additional information that is needed for each specific case can also easily be included in the lead time tree. The adapted lead time tree model has proven to have additional areas of use within project planning, improvement work regarding lead time reduction and root-cause analysis, and as a boundary object for communication between internal actors and between internal and external actors. The adapted lead time tree model is presumably able to map and visualize immaterial activities in other fields of business as well, other than manufacturing, as the nature of immaterial activities remains the same across business environments.

CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior / A indÃstria nacional calÃadista tem enfrentado o desafio de uma globalizaÃÃo inevitÃvel que acarreta uma concorrÃncia desleal com os paÃses asiÃticos. Esse cenÃrio sugere como uma ferramenta eficaz, a integraÃÃo entre as empresas para o seu fortalecimento e assim, responder a esta globalizaÃÃo atravÃs do aumento da sua capacidade competitiva, por meio do uso eficiente de inovaÃÃes tecnolÃgicas que tÃm impulsionado mundialmente o setor, como a tecnologia da informaÃÃo aplicada ao gerenciamento do fluxo logÃstico. No entanto, alÃm do associativismo essencial, as empresas necessitam rever sua tradicional cultura organizacional e alinhar sua visÃo estratÃgica para o cenÃrio descrito anteriormente e, disseminar, fazer com que essa visÃo alcance de maneira satisfatÃria o setor produtivo, atingindo principalmente a quem interessa: os consumidores. Com isso, o presente trabalho propÃe um mÃtodo de anÃlise da eficiÃncia do fluxo logÃstico em uma empresa do ramo calÃadista, fundamentado no mapeamento do processo e no desenvolvimento de um modelo de gestÃo de indicadores estratÃgicos, apresentando uma metodologia que auxiliarà na avaliaÃÃo das suas operaÃÃes logÃsticas, mapeando seu fluxo logÃstico e auxiliando na tomada de decisÃo para tornar a cadeia de suprimentos mais eficiente e flexÃvel. Portanto, contribuindo para a capacidade de absorÃÃo das oportunidades tecnolÃgicas de integraÃÃo dos elos da cadeia, como a tecnologia da informaÃÃo. O estudo se dà atravÃs do mapeamento do fluxo logÃstico e na gestÃo da utilizaÃÃo dos indicadores de desempenho estratÃgicos, teve como foco uma empresa do ramo calÃadista pertencente ao arranjo produtivo local (APL) do cariri cearense que, por sua vez, se destaca como um dos principais polos produtores calÃadistas no cenÃrio nacional. / A indÃstria nacional calÃadista tem enfrentado o desafio de uma globalizaÃÃo inevitÃvel que acarreta uma concorrÃncia desleal com os paÃses asiÃticos. Esse cenÃrio sugere como uma ferramenta eficaz, a integraÃÃo entre as empresas para o seu fortalecimento e assim, responder a esta globalizaÃÃo atravÃs do aumento da sua capacidade competitiva, por meio do uso eficiente de inovaÃÃes tecnolÃgicas que tÃm impulsionado mundialmente o setor, como a tecnologia da informaÃÃo aplicada ao gerenciamento do fluxo logÃstico. No entanto, alÃm do associativismo essencial, as empresas necessitam rever sua tradicional cultura organizacional e alinhar sua visÃo estratÃgica para o cenÃrio descrito anteriormente e, disseminar, fazer com que essa visÃo alcance de maneira satisfatÃria o setor produtivo, atingindo principalmente a quem interessa: os consumidores. Com isso, o presente trabalho propÃe um mÃtodo de anÃlise da eficiÃncia do fluxo logÃstico em uma empresa do ramo calÃadista, fundamentado no mapeamento do processo e no desenvolvimento de um modelo de gestÃo de indicadores estratÃgicos, apresentando uma metodologia que auxiliarà na avaliaÃÃo das suas operaÃÃes logÃsticas, mapeando seu fluxo logÃstico e auxiliando na tomada de decisÃo para tornar a cadeia de suprimentos mais eficiente e flexÃvel. Portanto, contribuindo para a capacidade de absorÃÃo das oportunidades tecnolÃgicas de integraÃÃo dos elos da cadeia, como a tecnologia da informaÃÃo. O estudo se dà atravÃs do mapeamento do fluxo logÃstico e na gestÃo da utilizaÃÃo dos indicadores de desempenho estratÃgicos, teve como foco uma empresa do ramo calÃadista pertencente ao arranjo produtivo local (APL) do cariri cearense que, por sua vez, se destaca como um dos principais polos produtores calÃadistas no cenÃrio nacional. / The domestic footwear industry has faced the challenge of an inevitable globalization that leads to unfair competition with Asian countries. This scenario suggests as an effective tool, the integration between the companies for their strengthening and thus respond to this globalization by increasing their competitiveness through the efficient use of technological innovations that have driven the industry globally, as technology information applied to the management of logistics flow. However, beyond the essential associations, companies need to review their traditional organizational culture and align its strategic vision for the scenario described above, and disseminate, make that vision satisfactorily reach the productive sector, affecting mostly those who matter: the consumers. Thus, this paper proposes a method of analyzing the efficiency of logistics flow in a company in the footwear business, based on the process mapping and the development of a management model of strategic indicators, presenting a methodology that will assist in the evaluation of its operations logistics, mapping its logistics flow and aiding in the decision to make the supply chain more efficient and flexible. Thus contributing to the absorption capacity of the technological opportunities of integrating parts of the chain, such as information technology. The study is done by mapping the logistics flow and managing the use of strategic performance indicators, a company focused on the footwear branch belonging to the local productive arrangement (APL) in Cearà cariri which, in turn, stands out as a major footwear producers poles on the national scene. / The domestic footwear industry has faced the challenge of an inevitable globalization that leads to unfair competition with Asian countries. This scenario suggests as an effective tool, the integration between the companies for their strengthening and thus respond to this globalization by increasing their competitiveness through the efficient use of technological innovations that have driven the industry globally, as technology information applied to the management of logistics flow. However, beyond the essential associations, companies need to review their traditional organizational culture and align its strategic vision for the scenario described above, and disseminate, make that vision satisfactorily reach the productive sector, affecting mostly those who matter: the consumers. Thus, this paper proposes a method of analyzing the efficiency of logistics flow in a company in the footwear business, based on the process mapping and the development of a management model of strategic indicators, presenting a methodology that will assist in the evaluation of its operations logistics, mapping its logistics flow and aiding in the decision to make the supply chain more efficient and flexible. Thus contributing to the absorption capacity of the technological opportunities of integrating parts of the chain, such as information technology. The study is done by mapping the logistics flow and managing the use of strategic performance indicators, a company focused on the footwear branch belonging to the local productive arrangement (APL) in Cearà cariri which, in turn, stands out as a major footwear producers poles on the national scene.

Inverse, multidimensional input-output flow mapping is very important for use of valves in precision motion control applications. Due to the highly nonlinear characteristic and uncertain model structure of the cartridge valves, it is hard to formulate the modelling of their flow mappings into simple parameter estimation problems. This contribution conducts a comprehensive analysis and validation of three- and four-dimensional input-output-mapping approaches for a proportional pilot operated seat valves. Therefore, a virtual and a physical test-rig setup are utilized for initial measurement, implementation and assessment. After modeling and validating the valve under consideration, as a function of flow, pressure and temperature different mapping methods are investigated. More specifically, state of the art approaches, deep-learning methods and a newly developed approach (extPoly) are examined. Especially ANNs and Polynomials show reasonable approximation results even for more than two inputs. However, the results are strongly dependent on the structure and distribution of the input data points. Besides identification effort, the invertibility was investigated.