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Inter-rela??o de aspectos cl?nicos, histomorfom?tricos e imunoistoqu?micos na paracoccidioidomicose oralSilva, Mariana ?lvares de Abreu e 31 August 2012 (has links)
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Previous issue date: 2012-08-31 / The present study aimed at analyzing histomorphometric, immunohistochemical and clinical features of oral lesions of paracoccidioidomycosis. The sample comprised 50 medical charts and 50 paraffinized blocks of biopsed specimens of oral leisons, both from paracoccidioidomycosis patients diagnosed at Stomatology Department of Hospital S?o Lucas, PUCRS from 1977 to 2010. Data regarding disease duration, and size and number of oral lesions, as well as erythrocytes, leukocytes, lymphocytes, hematocrit, hemoglobin and erythrocyte sedimentation rate, were collected from medical charts. Histological cuts were obtained from the paraffinized specimens and subjected to hematoxylin and eosin (H&E), Gomori-Grocott and immunohistochemical staining. The sample was classified according to the density of granulomas, and the variables number and diameter of fungi, number and diameter of buds, and IL-2, TNF-alpha and IFN-gamma expression were analyzed and correlated. Bud diameter was significantly greater in intermediate density granulomas compared to higher density granulomas. The other variables (bud number, number and diameter of fungi, expression of IL-2, TNF-alpha and IFN-gamma, and clinical and hematological features) did not significantly change with the density of granulomas. There was a positive correlation between bud number and fungal cell number (r=0.834), bud diameter and fungal cell diameter (r=0.496), erythrocytes and number of fungi (r=0.420), erythrocytes and bud number (r=0.408), and leukocytes and bud number (r=0.396). Negative correlation occurred between number and diameter of fungal cells (r=-0.419), bud diameter and granuloma density (r=-0.367), TNF-alpha expression and number of fungal cells (r=-0.372), TNF-alpha expression and bud number (r=-0.300). Histological, immunological and clinical characteristics of oral lesions of chronic paracoccidioidomycosis did not differ significantly between patients in our sample. TNF-alpha levels in oral lesions were inversely correlated with intensity of infection. / O presente estudo teve por objetivo analisar caracter?sticas histomorfom?tricas, imunoistoqu?micas e cl?nicas de les?es orais da paracoccidioidomicose. A amostra foi composta por 50 prontu?rios e 50 blocos de parafina contendo esp?cimes biopsiados de les?es orais, ambos provenientes de pacientes portadores de paracoccidioidomicose diagnosticados no Servi?o de Estomatologia do Hospital S?o Lucas da PUCRS no per?odo compreendido entre os anos de 1977 e 2010. Informa??es sobre tempo de evolu??o da doen?a, n?mero e tamanho das les?es orais, bem como contagem de eritr?citos, leuc?citos, linf?citos, hemat?crito, hemoglobina e eritrossedimenta??o foram coletadas dos prontu?rios dos pacientes. Cortes histol?gicos obtidos a partir dos esp?cimes em parafina foram submetidos ?s colora??es de hematoxilina e eosina (H&E), Gomori-Grocott e processamento imunoistoqu?mico. As amostras foram agrupadas de acordo com a intensidade de compacta??o do granuloma, e as vari?veis n?mero de fungos, n?mero de brotamentos, di?metro dos fungos, di?metro dos brotamentos, express?o imunoistoqu?mica de IL-2, TNF-alfa e IFN-gama foram avaliadas e correlacionadas. O di?metro dos brotamentos foi significativamente maior nos granulomas de compacta??o intermedi?ria quando comparados aos granulomas de maior compacta??o. As demais vari?veis (n?mero de brotamentos, n?mero e di?metro dos fungos, express?o de IL-2, TNF-alfa e IFN-gama, caracter?sticas cl?nicas e hematol?gicas) n?o exibiram altera??o significativa de acordo com o grau de compacta??o dos granulomas. Foi observada correla??o positiva entre n?mero de brotamentos e n?mero de fungos (r=0.834); di?metro dos brotamentos e di?metro do fungo (r=0.496); eritr?citos e n?mero de fungos (r=0.420); eritr?citos e n?mero de brotamentos (r=0.408); leuc?citos e n?mero de brotamentos (r=0.396). A correla??o negativa ocorreu entre di?metro e n?mero de fungos (r=-0.419); di?metro dos brotamentos e compacta??o do granuloma (r=-0.367); express?o de TNF-alfa e n?mero de fungos (r=-0.372); express?o de TNF-alfa e n?mero de brotamentos (r=-0.300). As caracter?sticas histol?gicas, imunol?gicas e cl?nicas das les?es orais da paracoccidioidomicose cr?nica n?o diferiram significativamente entre os pacientes da amostra avaliada. Os n?veis de TNF-alfa nas les?es orais est?o inversamente relacionados ? intensidade da infec??o.
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REDUCTION OF TRANSVERSE CRACKING IN STRUCTURAL SLAB BRIDGE DECKS USING ALTERNATIVE MATERIALSMarchetty, Srikanth 23 May 2018 (has links)
No description available.
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Modelamiento hidrológico de caudales medios mensuales en cuencas sin información hidrométrica aplicando el método Lutz Scholz y las redes neuronales artificiales, en la microcuenca Huajuiri - Oropesa - Antabamba - Apurímac / Hydrological modeling of monthly average flows in basins without hydrometric information applying Lutz Scholz method and artificial neural networks, in Huajuiri micro basin - Oropesa - Antabamba - ApurímacZárate Torres, Cynthia 30 December 2020 (has links)
El problema central planteado en la presente tesis de investigación es la falta de información hidrométrica en algunas cuencas del Perú, en este caso en la microcuenca Huajuiri, localizado en el distrito de Oropesa, provincia de Antabamba, departamento de Apurímac; puesto que al existir un déficit de estaciones hidrométricas respecto a la cantidad de cuencas existentes a nivel nacional, la información hidrométrica es insuficiente y deficiente, lo que trae como consecuencia no contar con datos como los caudales medios mensuales, información hidrológica relevante para poder conocer la disponibilidad del agua en la cuenca para efectuar la distribución del recurso hídrico de acuerdo al requerimiento de las comunidades campesinas aledañas a la fuente de agua, es útil para diseñar futuras obras hidráulicas, así como para realizar proyecciones respecto al comportamiento hídrico de la cuenca.
Es por esta razón que se plantea el cálculo de los caudales medios mensuales en cuencas que no disponen de datos hidrométricos, utilizando el método Lutz Scholz y las redes neuronales artificiales.
En la cuenca con información hidrométrica (La Angostura) con los modelamientos hidrológicos planteados, se obtuvieron valores cercanos a los caudales medios mensuales medidos. Sin embargo, en la cuenca sin información hidrométrica (Huajuiri), la inclusión en el modelamiento hidrológico de las redes neuronales artificiales permitió obtener valores más cercanos a los aforos realizados, que solamente aplicando el método Lutz Scholz. / Central problem exposed in this thesis is lack of hydrometric information in some basins of Peru, in our case in Huajuiri micro basin, located in Oropesa district, Antabamba province, Apurímac department, there is a deficit of hydrometric stations with respect to the number of existing basins at national level, hydrometric information is insufficient and deficient, which results in not having data such as average monthly flows, relevant hydrological information to be able to know the water availability of basin in order to distribute water according to requirements of rural communities surrounding the water source, it is useful to design future hydraulic construction, as well as to carry out projections regarding the water behavior of basin.
It is for this reason that calculation of average monthly flows in basins without information is proposed using Lutz Scholz method and artificial neural networks.
In basin with hydrometric information (La Angostura), with proposed hydrological modeling, values were obtained close to average monthly flows. However, in basin without hydrometric information (Huajuiri), inclusion in hydrological modeling of artificial neural networks allowed obtaining values closer to flow measurement, than only by applying Lutz Scholz method. / Tesis
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As filhas de Eva querem votar : dos primórdios da questão à conquista do sufrágio feminino no Brasil (c. 1850-1932) / The daughters of Eve want to vote: from the origins of the question to the conquest of women’s suffrage in Brazil (c.1850-1932)Karawejczyk, Mônica January 2013 (has links)
Esta tese procura compreender o processo que culminou com a conquista do voto feminino no Brasil em 24 de fevereiro de 1932. O objetivo é desvelar, analisar e compreender as articulações e os principais personagens que fizeram parte dessa conquista, tendo como limites temporais os anos de 1850 e 1932. A narrativa se centra em dois grupos principais. O primeiro grupo é representado pelos parlamentares brasileiros e as tentativas de inserção da mulher no pleito eleitoral, via legais, durante todo o período da Primeira República. O segundo grupo é representado pelas figuras de Leolinda de Figueiredo Daltro à frente do Partido Republicano Feminino e de Bertha Lutz, líder da Federação Brasileira pelo Progresso Feminino, ambas responsáveis pela articulação do movimento organizado feminino e sufragista no Brasil. A vertente a que esse trabalho se vincula é a dos estudos de gênero e da história política, no sentido que trata da luta em prol do sufrágio feminino procurando dar ênfase tanto aos atores convencionais do jogo político como para as mulheres que se organizaram para reivindicar seus direitos. Através da análise de um conjunto heterogêneo de fontes, tais como: Anais do Congresso Nacional, correspondências, matérias de jornais e revistas, materiais bibliográficos diversos e pesquisas acadêmicas, procura-se também acentuar que mais do que uma concessão do governo de Getúlio Vargas, o sufrágio feminino foi o resultado de uma longa luta empreendida por homens e mulheres em prol da igualdade eleitoral. / This thesis seeks to understand the process leading to the conquest of women’s suffrage in Brazil on February 24th, 1932. The objective is to uncover, analyze and comprehend the articulations and main characters that were part of these achievements, setting the years 1850 to 1932 as the timeframe for this investigation. The narrative is centered on two main groups. The first group is represented by Brazilian congressmen and the successive attempts to legally insert women in the electoral process during the entire period of the First Republic. The second group is represented by the figures of Leolinda de Figueiredo Daltro, heading the Women’s Republican Party and Bertha Luz, leader of the Brazilian Federation for Women’s Progress, both responsible for the articulation of the organized feminist and suffragist movement in Brazil. This work is best understood as a piece on gender studies and political history, as it deals with the struggle for women’s suffrage, aiming to focus on the conventional actors in the political game as well as the women who organized to claim their rights. Through an analysis of a heterogeneous set of sources, such as the Annals of the Parliament, correspondence exchange, newspaper and magazine articles, and academic research this work seeks to stress that women’s suffrage in Brazil was the result of a long struggle by women and men for electoral equality, rather than a concession of Getulio Vargas’ government.
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As filhas de Eva querem votar : dos primórdios da questão à conquista do sufrágio feminino no Brasil (c. 1850-1932) / The daughters of Eve want to vote: from the origins of the question to the conquest of women’s suffrage in Brazil (c.1850-1932)Karawejczyk, Mônica January 2013 (has links)
Esta tese procura compreender o processo que culminou com a conquista do voto feminino no Brasil em 24 de fevereiro de 1932. O objetivo é desvelar, analisar e compreender as articulações e os principais personagens que fizeram parte dessa conquista, tendo como limites temporais os anos de 1850 e 1932. A narrativa se centra em dois grupos principais. O primeiro grupo é representado pelos parlamentares brasileiros e as tentativas de inserção da mulher no pleito eleitoral, via legais, durante todo o período da Primeira República. O segundo grupo é representado pelas figuras de Leolinda de Figueiredo Daltro à frente do Partido Republicano Feminino e de Bertha Lutz, líder da Federação Brasileira pelo Progresso Feminino, ambas responsáveis pela articulação do movimento organizado feminino e sufragista no Brasil. A vertente a que esse trabalho se vincula é a dos estudos de gênero e da história política, no sentido que trata da luta em prol do sufrágio feminino procurando dar ênfase tanto aos atores convencionais do jogo político como para as mulheres que se organizaram para reivindicar seus direitos. Através da análise de um conjunto heterogêneo de fontes, tais como: Anais do Congresso Nacional, correspondências, matérias de jornais e revistas, materiais bibliográficos diversos e pesquisas acadêmicas, procura-se também acentuar que mais do que uma concessão do governo de Getúlio Vargas, o sufrágio feminino foi o resultado de uma longa luta empreendida por homens e mulheres em prol da igualdade eleitoral. / This thesis seeks to understand the process leading to the conquest of women’s suffrage in Brazil on February 24th, 1932. The objective is to uncover, analyze and comprehend the articulations and main characters that were part of these achievements, setting the years 1850 to 1932 as the timeframe for this investigation. The narrative is centered on two main groups. The first group is represented by Brazilian congressmen and the successive attempts to legally insert women in the electoral process during the entire period of the First Republic. The second group is represented by the figures of Leolinda de Figueiredo Daltro, heading the Women’s Republican Party and Bertha Luz, leader of the Brazilian Federation for Women’s Progress, both responsible for the articulation of the organized feminist and suffragist movement in Brazil. This work is best understood as a piece on gender studies and political history, as it deals with the struggle for women’s suffrage, aiming to focus on the conventional actors in the political game as well as the women who organized to claim their rights. Through an analysis of a heterogeneous set of sources, such as the Annals of the Parliament, correspondence exchange, newspaper and magazine articles, and academic research this work seeks to stress that women’s suffrage in Brazil was the result of a long struggle by women and men for electoral equality, rather than a concession of Getulio Vargas’ government.
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As filhas de Eva querem votar : dos primórdios da questão à conquista do sufrágio feminino no Brasil (c. 1850-1932) / The daughters of Eve want to vote: from the origins of the question to the conquest of women’s suffrage in Brazil (c.1850-1932)Karawejczyk, Mônica January 2013 (has links)
Esta tese procura compreender o processo que culminou com a conquista do voto feminino no Brasil em 24 de fevereiro de 1932. O objetivo é desvelar, analisar e compreender as articulações e os principais personagens que fizeram parte dessa conquista, tendo como limites temporais os anos de 1850 e 1932. A narrativa se centra em dois grupos principais. O primeiro grupo é representado pelos parlamentares brasileiros e as tentativas de inserção da mulher no pleito eleitoral, via legais, durante todo o período da Primeira República. O segundo grupo é representado pelas figuras de Leolinda de Figueiredo Daltro à frente do Partido Republicano Feminino e de Bertha Lutz, líder da Federação Brasileira pelo Progresso Feminino, ambas responsáveis pela articulação do movimento organizado feminino e sufragista no Brasil. A vertente a que esse trabalho se vincula é a dos estudos de gênero e da história política, no sentido que trata da luta em prol do sufrágio feminino procurando dar ênfase tanto aos atores convencionais do jogo político como para as mulheres que se organizaram para reivindicar seus direitos. Através da análise de um conjunto heterogêneo de fontes, tais como: Anais do Congresso Nacional, correspondências, matérias de jornais e revistas, materiais bibliográficos diversos e pesquisas acadêmicas, procura-se também acentuar que mais do que uma concessão do governo de Getúlio Vargas, o sufrágio feminino foi o resultado de uma longa luta empreendida por homens e mulheres em prol da igualdade eleitoral. / This thesis seeks to understand the process leading to the conquest of women’s suffrage in Brazil on February 24th, 1932. The objective is to uncover, analyze and comprehend the articulations and main characters that were part of these achievements, setting the years 1850 to 1932 as the timeframe for this investigation. The narrative is centered on two main groups. The first group is represented by Brazilian congressmen and the successive attempts to legally insert women in the electoral process during the entire period of the First Republic. The second group is represented by the figures of Leolinda de Figueiredo Daltro, heading the Women’s Republican Party and Bertha Luz, leader of the Brazilian Federation for Women’s Progress, both responsible for the articulation of the organized feminist and suffragist movement in Brazil. This work is best understood as a piece on gender studies and political history, as it deals with the struggle for women’s suffrage, aiming to focus on the conventional actors in the political game as well as the women who organized to claim their rights. Through an analysis of a heterogeneous set of sources, such as the Annals of the Parliament, correspondence exchange, newspaper and magazine articles, and academic research this work seeks to stress that women’s suffrage in Brazil was the result of a long struggle by women and men for electoral equality, rather than a concession of Getulio Vargas’ government.
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Action in Chronic Fatigue Syndrome: an Enactive Psycho-phenomenological and Semiotic Analysis of Thirty New Zealand Women's Experiences of Suffering and RecoveryHart, M J Alexandra January 2010 (has links)
This research into Chronic Fatigue Syndrome (CFS) presents the results of 60 first-person psycho-phenomenological interviews with 30 New Zealand women. The participants were recruited from the Canterbury and Wellington regions, 10 had recovered. Taking a non-dual, non-reductive embodied approach, the phenomenological data was analysed semiotically, using a graph-theoretical cluster analysis to elucidate the large number of resulting categories, and interpreted through the enactive approach to cognitive science.
The initial result of the analysis is a comprehensive exploration of the experience of CFS which develops subject-specific categories of experience and explores the relation of the illness to universal categories of experience, including self, ‘energy’, action, and being-able-to-do.
Transformations of the self surrounding being-able-to-do and not-being-able-to-do were shown to elucidate the illness process.
It is proposed that the concept ‘energy’ in the participants’ discourse is equivalent to the Mahayana Buddhist concept of ‘contact’. This characterises CFS as a breakdown of contact. Narrative content from the recovered interviewees reflects a reestablishment of contact.
The hypothesis that CFS is a disorder of action is investigated in detail.
A general model for the phenomenology and functional architecture of action is proposed. This model is a recursive loop involving felt meaning, contact, action, and perception and appears to be phenomenologically supported.
It is proposed that the CFS illness process is a dynamical decompensation of the subject’s action loop caused by a breakdown in the process of contact.
On this basis, a new interpretation of neurological findings in relation to CFS becomes possible. A neurological phenomenon that correlates with the illness and involves a brain region that has a similar structure to the action model’s recursive loop is identified in previous research results and compared with the action model and the results of this research. This correspondence may identify the brain regions involved in the illness process, which may provide an objective diagnostic test for the condition and approaches to treatment.
The implications of this model for cognitive science and CFS should be investigated through neurophenomenological research since the model stands to shed considerable light on the nature of consciousness, contact and agency.
Phenomenologically based treatments are proposed, along with suggestions for future research on CFS. The research may clarify the diagnostic criteria for CFS and guide management and treatment programmes, particularly multidimensional and interdisciplinary approaches.
Category theory is proposed as a foundation for a mathematisation of phenomenology.
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