This thesis examines US protectionism in the 1980s from Canadian and American perspectives, and its role in Canada’s pursuit of the historic 1988 Canada-US Free Trade Agreement. It analyzes the perceived “threat” of protectionism and evaluates the agreement’s provisions against Canada’s goal of securing access to the US market. It contends that US protectionism was crucial in the Mulroney government’s decision to negotiate a bilateral agreement and was a contentious issue for the agreement’s critics. US sources, unexamined in existing historiography, confirm the increased threat of American protectionism, but emphasize a distinction between the threat and implementation of protectionist trade law. Although the agreement did not shield Canada from US trade remedies, Canada gained important presence in the trade dispute process. These conclusions are drawn from Canadian and American media and government documents, 1980s academic and think-tank commentary, legal documents, the memoirs and diaries of major players, and select archival sources.

技師服務具有高度專業性與技術性，且與一國基礎建設具重大關係，攸關人民生命財產安全，往往受到各國政府之管制。各國為確保技師服務提供之品質，通常對於技師服務進行證照管制，令技師服務之提供限於取得該國技師資格與執業執照者始得為之。有關技師資格與核發執業執照之規定通常散落於各國國內規章中，該等國內規章之適用勢必將對技師服務貿易產生影響。 在世界貿易組織(World Trade Organization，以下簡稱WTO)之服務貿易總協定下(General Agreement on Trade in Services)，WTO會員基於自願性之基礎對各項服務部門之市場開放提出承諾，技師服務屬於專業服務之範疇，亦包含於會員可能提出開放承諾之範圍內。由於各會員國內規章之規定並不須納入會員服務貿易特定承諾表內，因此若欲了解技師服務貿易自由化之情形，除須檢視各國對於技師服務所為之開放承諾外，亦應瞭解國內規章對於技師服務貿易所造成之限制。 本文以技師資格相關之國內規章為出發點，探討國內規章對於技師服務貿易自由化所產生之影響，並針對目前國際間有關技師資格之相互認許進行討論，最後對於未來技師服務貿易自由化提出建議。 / Engineering services, with high professional specialty and technical background, plays an essential role in national infrastructure and is fatal to public security. To ensure the quality of the services provided, national governments usually implement the license regulation on engineering services. Only those who obtain the engineer qualification and acquire the license can practice their own specialty. The requirement for engineer qualification and license issuing, containing in the domestic regulations, will definitely have the impact on trades of engineering services. Under the General Agreement on Trade in Services of the World Trade Organization (hereinafter the “WTO”), WTO members make market-access commitments on a number of service sectors on the basis of voluntary. Since engineering services belongs to the category of professional services, it may also be the subject included in the commitments made by members. Since members have no obligations to inscribe domestic regulations in their schedules of specific commitments, with the purpose to understand the practical trade liberalization of engineering services, we should not simply focus on the commitments made by members, the limitation to trade of engineering services caused by domestic regulations should also be taken into consideration. This thesis initiates with the relevant domestic regulations of engineer qualification, observing how those regulations would affect the trade liberalization of engineering services. It accordingly discusses the nowadays international mutual recognition system of engineer qualification, and ends with some suggestions and thoughts regarding the future trade liberalization of engineering services.

製藥業和其他消費性用品產業有許多不同，像是需要大量地投資於新產品研發與創新。許多藥品和其他消費品相比，有較長的產品生命週期，而且藥品購買者通常並非是藥品使用者。儘管藥品有較長的生命週期，最終仍會面對專利到期的一天。對於製藥業而言，近年來的市場准入(market access)變得更具挑戰性，臨床試驗的障礙、法規核可，和健保給付核可價格也變得比以前困難。藥品需要較長時間以準備進入市場，因此在專利到期前的市場銷售期也縮短許多。如何在有限的市場銷售期極大化銷售業績和利潤對於藥品行銷者而言，也日益重要。即使是在專利過期後，如何管理以及延展藥品生命週期對於製藥業也是一門學問。 為了縮短藥品上市前的準備期，製藥公司需要了解管制法規的申請策略，和選擇最適宜者。下一步是思考健保價格策略。了解中央健康保險局的機制，可以有效減少反覆送件的過程。 度過藥品上市前的準備期後，下一個任務是如何延展產品生命週期。常見策略有1)增加原藥品的新適應症；2)推出機轉類似，但稍微改良過的新產品，以替換即將專利保護過期的藥品；3)將即將專利保護過期的舊產品在劑型上導入新科技，而此新劑型具有專利保護;4)導入固定劑量複方藥品;5)投資學名藥。 產品生命週期的管理對於製藥業非常重要，公司應該強化縮短產品上市前準備期間的能力，在市場銷售期極大化銷售業績與利潤，並在專利到期後延展產品生命週期。 對健康保險環境的研究，以及醫生行為受保險體制的改變，與長時間對人們健康的影響仍待未來進行進一步地探討。 / Pharmaceutical industry is quite different from other consumer products industry. It needs heavy investment on product development and innovation. Most of drugs have longer lifecycle than consumer products, and usually the drug buyer is not drug user. Though drug has long lifecycle, eventually it will face patent-off. Recently market access becomes more and more challenging for pharmaceutical industry. The barriers of clinical trials, regulatory approval, and reimbursement price approval are more difficult than before. Drugs need longer time to go-to-market, and the period of commercialization before patent-off is shorter. How to maximize sales and profits within limited commercialization time becomes more critical for marketers. And how to well manage drug lifecycle and extend lifecycle even after patent-off are the other crucial lessons for industry. In order to shorten “go-to-market” period, drug company needs to understand the regulatory submission strategies, and choose the most appropriate one for submission. Next step is considering reimbursement price strategies. Understanding Bureau of National Health Insurance’s (BNHI) mechanism can minimize back-and-forth process. After “go-to-market”, the next task is how to extend product lifecycle. The most common methods are 1) launch new indication, 2) launch new/ improved generation to replace old drug, 3) launch new dosage/ presentation form, which have patent to extend compound patent, 4) introduce fix-dosed combination, 5) invest in generics. Lifecycle management is critical for pharmaceutical industry. Company should strengthen the competencies to shorten product “go-to-market” period, maximize the sales and profits during commercialization, and extend lifecycle after patent-off. The research of health insurance environment, the changes of physicians’ behaviors and impacts on people health need further studies.

Made available in DSpace on 2016-03-15T19:33:56Z (GMT). No. of bitstreams: 1 Carlos Willians Osorio.pdf: 1082658 bytes, checksum: 73921d0f02d430dfae4fa6fce3d3d35c (MD5) Previous issue date: 2013-08-08 / The small business is one of the main pillars of the economy, both the number of establishments and geographical desconcentration, as its ability to generate jobs statistically proven facts. For this reason, they become deserving of public policies to support and encourage the growth, profitability and business sustainability. From this evidence, the limitation of the study includes understanding the importance of this segment to the country, combined with the effectiveness of public policies intended for, in the context of differential treatment guaranteed by the fundamental rule. / A empresa de pequeno porte constitui um dos principais pilares de sustentação da economia, tanto pelo número de estabelecimentos e desconcentração geográfica, quanto pela sua capacidade de gerar empregos fatos comprovados estatisticamente. Por essa razão, tornam-se merecedoras de políticas públicas de apoio e incentivo ao seu crescimento, rentabilidade e sustentabilidade empresarial. A partir dessa constatação, a limitação do estudo abarca a compreensão da relevância desse segmento para o país, articulada com a efetividade das políticas públicas a ele destinadas, no contexto do tratamento diferenciado garantido pelo Texto Fundamental.

La finalité du droit international économique contemporain est en principe de réaliser une meilleure harmonisation entre l’expansion du commerce d’une part et la croissance des pays en développement (PED) d’autre part. Cette harmonisation n’est pas toujours évidente dans certains domaines du droit international économique notamment les services. Les rapports juridiques entre un accord multilatéral comme l’AGCS (Accord général sur le commerce des services) et les PED représentent en effet, une dialectique tant au niveau du statut des PED dans le cadre de cet Accord que de ses conséquences juridiques à leur égard. L’étude s’inscrit dans le cadre de cette dialectique et tente de cerner la dimension juridique et les enjeux de développement de ces rapports. Elle se place dans ce contexte à montrer la flexibilité formelle de l’AGCS à l’égard des PED dans un premier lieu et la relativité de ses effets dans un second lieu. / The aim of the contemporary international economic law is in principle to achieve a better harmonization between the expansion of trade and the growth of the developing countries. This harmonization is not always evident or clear in some areas of the international economic law particularly in the services sector. The legal aspects of the relationship between a multilateral Agreement such as the GATS (General Agreement on Trade in Services) and developing countries are indeed dialectic especially in the context of their status in the framework of this Agreement on the one hand and its legal consequences on the other hand. The study takes its place in this dialectic and attempts to identify the legal dimension and the development challenges of this relationship. It is within this context that the research will present the formal flexibility of the GATS against the developing countries in the first place and the relativity of its effects in a second.

La thèse examine les configurations d'acteurs et d'organisations impliquées dans la régulation de l'accès au marché des médicaments en France et en Angleterre, en charge du contrôle scientifique et administratif de la fixation du prix et du remboursement de ces produits. Cette activité s'autonomise de l'appréciation clinique de leur qualité, de leur efficacité et de leur innocuité (dominant la régulation de leur approbation sur le marché) au cours des années 1980. / This thesis examines the configurations of actors and organizations involved in the regulation of the market access for drugs in France and England. Since the mid-1980s, this process has entailed the development of administrative and scientific controls over the fixing of the price and the conditions of reimbursement of these products. These controls have become autonomus from clinical appreciation of their quality, efficacity and safety that dominate approval regulation as a whole.

My doctoral thesis examines the broad question of whether appropriately designed institutions and policies can address the short- and long-term consequences of determinants of human capital which are "immutable'' by nature or are perceived as such. I consider three different types of immutable determinants of human capital: male versus female biology; colonization; and traditional norms of gender roles. In Chapter 1, I examine whether, and how, change in political regime type affects excess male infant mortality. Analyzing data on more than 3 million live births from sub-Saharan African countries, I exploit within-mother variation in political regime type to find that excess male infant mortality significantly decreases following a transition to democracy. I identify competitiveness of executive recruitment, constraints on the chief executive, and political participation as the features of democracy that matter most. Examining causal mechanisms, I find that democracy fosters the provision of health inputs, including maternal education, tetanus immunization, breastfeeding, and normal birth weight, all of which have stronger health benefits for boys than for girls, despite being found to be ex-ante "gender-neutral'' in my setting. In Chapter 2, I examine how colonial reproductive laws interact with market incentives to shape long-term fertility behavior in Africa. Exploiting the arbitrary division of ancestral ethnic homelands and the resulting discontinuity in institutions across the British-French colonial borders, I find that women in former British areas are more likely to delay sexual debut and marriage, and have fewer children. However, these effects disappear in areas close to sea, where market access and the opportunity cost of childbearing appear to be high irrespective of the colonizer identity. This heterogeneous impact of colonial origins extends to measures of local economic development and household welfare. Examining causal mechanisms, I argue that the fertility effect of colonial origins is directly linked to colonial population policies and reproductive laws and their impact on the use of modern methods of birth control. I find little evidence that the fertility effect of British colonization operates through education or income. While British colonization is linked to higher female education levels, this occurs mainly close to the sea while the fertility effects do not. Again, while income levels differ, the fertility gap between British and French colonies opened prior to 1980, while the income gap opened-up after 1990. This chapter highlights the heterogeneous nature of the colonial origins of comparative fertility behavior and economic development, and implies that economic incentives may overcome historical determinism. In Chapter 3, I examine the interplay between legal origins and pre-colonial cultural norms of gender roles in determining female economic empowerment in sub-Saharan Africa. Taking advantage of the arbitrary division of ancestral ethnic homelands across countries with different legal origins, I directly compare women among the same ethnic group living in civil law countries and common law countries. I find that women in common law countries are significantly more educated, are more likely to work in the professional sector, and are less likely to marry at young age. However, these effects are either absent or significantly lower in settings where ancestral cultural norms do not promote women's rights and empowerment. In particular, I find little effect in bride price societies, patrilocal societies, and societies where women were not involved in agriculture in the past.

[pt] Neste trabalho, estudo a oferta e demanda por habitação na Região Metropolitana de São Paulo, uma das principais cidades do Brasil. Usando dados detalhados de deslocamento ao trabalho, eu estimo um modelo quantitativo espacial, no qual agentes tomam decisões sobre local de residência e trabalho com base em aluguéis, salários, custos de deslocamento e amenidades. Proponho uma extensão do arcabouço usual com um setor formal de oferta de moradia para incluir também um setor informal em competição, uma importante característica institucional presente em diversos países em desenvolvimento. Eu quantifico os spillovers espaciais associados ao setor informal e investigo seu papel em prover residentes com melhor acesso ao mercado de trabalho local. / [en] In this work, I study the supply and demand for housing in the São Paulo Metropolitan Area, a major city in Brazil. Using detailed commuting data, I estimate a quantitative spatial model, in which agents make decisions on residence and workplace based on local rents, wages, commuting costs, and amenities. I propose an extension of the usual framework with a formal housing supply sector to include a competing informal one, an important institutional characteristic present in many developing countries. I quantify the spatial spillovers of this informal housing, and investigate its role in providing residents with improved access to the local labor market.

This thesis brings together for the first time, in an organised account, Saskatchewans search for a pulp industry. This thesis will show that, in a fundamental tension between goals of fiscal prudence and of economic growth, fiscal prudence won out again and again, to the point that the CCF governments could be characterised as risk-averse where pulp production was concerned. The cautious approach is in contradiction both to the activist reputation of the CCF governments and to their aggressive development of other resources, notably mining. Pulp offers an example of the contradictions that plagued the CCF governments and their policies for the north, contradictions that included disagreements between moderates and radicals over the roles of public and multinational enterprise, colonial attitudes towards the north, and risk aversion despite bold rhetoric and announcements.<p>The methodology used in this thesis has generally maintained an economic policy and political discourse, and incorporates mostly a top-down governmental approach. The personal papers of Tommy Douglas and Woodrow Lloyd provided CCF government correspondence and departmental memos that included premiers, ministers, deputy ministers, and departmental directors involved with the Department of Natural Resources, the Timber Board, the Industrial Development Office, and the Economic Advisory and Planning Board, and with pulp company officials. Furthermore, pulp reports, surveys, and studies helped contextualise all of the interrelated correspondences. To supplement government discourse I utilised the Prince Albert Daily Herald to gain an understanding of what issues the public was debating and found to be most important.

This thesis brings together for the first time, in an organised account, Saskatchewans search for a pulp industry. This thesis will show that, in a fundamental tension between goals of fiscal prudence and of economic growth, fiscal prudence won out again and again, to the point that the CCF governments could be characterised as risk-averse where pulp production was concerned. The cautious approach is in contradiction both to the activist reputation of the CCF governments and to their aggressive development of other resources, notably mining. Pulp offers an example of the contradictions that plagued the CCF governments and their policies for the north, contradictions that included disagreements between moderates and radicals over the roles of public and multinational enterprise, colonial attitudes towards the north, and risk aversion despite bold rhetoric and announcements.<p>The methodology used in this thesis has generally maintained an economic policy and political discourse, and incorporates mostly a top-down governmental approach. The personal papers of Tommy Douglas and Woodrow Lloyd provided CCF government correspondence and departmental memos that included premiers, ministers, deputy ministers, and departmental directors involved with the Department of Natural Resources, the Timber Board, the Industrial Development Office, and the Economic Advisory and Planning Board, and with pulp company officials. Furthermore, pulp reports, surveys, and studies helped contextualise all of the interrelated correspondences. To supplement government discourse I utilised the Prince Albert Daily Herald to gain an understanding of what issues the public was debating and found to be most important.