This thesis describes the work of investigating and developing Arctic Paper Grycksbo’s work environment work, focusing on their use of the Paper industry’s information system on work environment (Pappersindustrins Informationssystem om Arbetsmiljö, PIA). The work took place between January and June 2018 as a final part of the Master Programme in Industrial Design Engineering at Luleå University of Technology. The client of the project was Arctic Paper Grycksbo, one of three paper mills in the Arctic Paper Group. The work began with a literature study where areas such as production design, safety, work environment management, risk analysis, etc. was covered. Subsequently, a comprehensive survey of the PIA system was conducted in parallel with a survey of the company’s overall work environment management. This resulted in a clear picture of how the system is used, the role of the system in the work environment management and where there were shortcomings in the work being done today. An  identified deficiency was that the quality of investigations of the reported events varied a lot depending on who performed the investigation, another identified deficiency was that there were a number of delayed events that appeared to be investigated and corrected but wasn’t marked as done in the system. To investigate how other companies use the system, a benchmarking was conducted where companies using any variant of the system got to answer how they use the system and what they like about the system. Based on the investigation of the system, Arctic Paper Grycksbo’s use of the system and the use of the benchmarked companies, six areas for improvement was identified, such as the uneven quality of investigation, the delayed events, their use of the risk management module and their analysing of the information in the system. When the areas of improvement were identified, the work was continued to develop how they could improve their use of PIA. First, six of the former benchmarked companies were contacted for more detailed interviews about how they use the system. Based on the deeper benchmarking, the theoretical framework and the areas where Arctic Paper Grycksbo can improve, new routines for Arctic Paper Grycksbo’s use of PIA was developed. As part of the routines, recommendations and instructions for statistics were also developed that they should begin to follow in the system. Arctic Paper Grycksbo is recommended to start following eight safety indicators, three leading and five lagging, and seven trends regarding the characteristics of accidents and incidents. The possibilities in the system are huge and there is a great potential to use it for most parts of the work environment work if you only set the time from the beginning and are aware that it requires some active work. / Det här examensarbetet beskriver arbetet med att undersöka och utveckla Arctic Paper Grycksbos arbetsmiljöarbete med fokus på deras användning av Pappersindustrins Informationssystem om Arbetsmiljö (PIA). Arbetet pågick mellan januari och juni 2018 som en avslutande del på civilingenjörsprogrammet Teknisk Design på Luleå Tekniska Universitet. Uppdragsgivare var Arctic Paper Grycksbo, ett av tre pappersbruk i Arctic Paper koncernen. Arbetet inleddes med en litteraturstudie där områden som produktionsdesign, säkerhet, arbetsmiljöarbete, riskanalys, m.m. behandlades. Därefter genomfördes en omfattande undersökning av PIA-systemet parallellt med en undersökning av företagets övergripande arbetsmiljöarbete. Detta resulterade i en tydlig bild av hur systemet används, systemets roll i arbetsmiljöarbetet och var det fanns brister i arbetet som görs idag. En brist som identifierades var att kvaliteten på utredningarna av de rapporterade händelserna varierade mycket beroende på vem som utfört utredningen, en annan brist som identifierades var att det fanns ett flertal förfallna händelser som såg ut att vara utredda och åtgärdade men saknade klarmarkering i systemet. För att undersöka hur andra företag använder systemet gjordes en benchmarking där företag som använder någon variant av systemet fick svara på hur de använder systemet och vad de tycker om systemet. Baserat på undersökningen av systemet, Arctic Paper Grycksbos användning av systemet och de benchmarkade företagens användning av systemet identifierades sex områden där de kan förbättra och utveckla sin användning av systemet, så som den ojämna kvaliteten på utredningarna, de förfallna händelserna, deras användning av riskhanteringsmodulen och deras användning av informationn i systemet. När förbättringsmöjligheterna var identifierade fortsatte arbetet med att utveckla hur de kan förbättra sig. Först så kontaktades sex av de tidigare benchmarkade företagen för mer detaljerade intervjuer av hur de använder systemet. Utifrån den djupare benchmarkingen, den teoretiska referensramen och de områden där Arctic Paper Grycksbo kan förbättra sig, utvecklades nya rutiner för användningen av PIA. Som en del av rutinerna utvecklades även rekommendationer och instruktioner för statistik de bör börja följa i systemet. Arctic Paper Grycksbo rekommenderas börja följa åtta säkerhetsindikatorer, tre ledande och fem eftersläpande, och sju trender gällande olyckornas och tillbudens egenskaper. Möjligheterna i systemet är enorma och det finns stor potential att nyttja det till de flesta delar av arbetsmiljöarbetet om man bara lägger tiden på det från början och är medveten om att det kräver visst aktivt arbete.

Submitted by Bruna Rodrigues (bruna92rodrigues@yahoo.com.br) on 2016-10-04T12:12:29Z No. of bitstreams: 1 DissJGOP.pdf: 2793515 bytes, checksum: df6d0f347964eb7ac9ac59179a2272bf (MD5) / Approved for entry into archive by Marina Freitas (marinapf@ufscar.br) on 2016-10-14T14:22:00Z (GMT) No. of bitstreams: 1 DissJGOP.pdf: 2793515 bytes, checksum: df6d0f347964eb7ac9ac59179a2272bf (MD5) / Approved for entry into archive by Marina Freitas (marinapf@ufscar.br) on 2016-10-14T14:22:10Z (GMT) No. of bitstreams: 1 DissJGOP.pdf: 2793515 bytes, checksum: df6d0f347964eb7ac9ac59179a2272bf (MD5) / Made available in DSpace on 2016-10-14T14:22:20Z (GMT). No. of bitstreams: 1 DissJGOP.pdf: 2793515 bytes, checksum: df6d0f347964eb7ac9ac59179a2272bf (MD5) Previous issue date: 2016-02-29 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Understanding that women's participation in the history of culture and in the history of education has been subject to a limited number of surveys, the present proposal aims to develop a study of the collection of documents belonging to Pia União das Filhas de Maria in São João da Boa Vista - SP present in the Sacred Art Museum of this city's Diocese in order to understand the role of women in that society and their educational and social function, as these women were catechists, music teachers and active in social-cultural projects related to catechesis and literacy . In this proposal we used, both record documents and minute and finance books, like women's choir sheet music and craft items produced by the association, as well as interviews granted by its former members. By the study of such documents on these women, it sought to unveil the possibility of their contribution to a characterization of a social and educational culture in the city of São João da Boa Vista in the first half of the twentieth century / Entendendo que a participação feminina na história da cultura e na história da educação tenha sido objeto de um número restrito de pesquisas, a presente proposta objetiva desenvolver um estudo do acervo de documentos da Pia União das Filhas de Maria de São João da Boa Vista - SP presentes no Museu de Arte Sacra da Diocese da cidade mencionada, a fim de compreender o papel da mulher naquela sociedade e a sua função socioeducacional, visto que essas mulheres eram catequistas, educadoras musicais e atuantes em projetos socioculturais relacionados com a catequese e a alfabetização. Utilizou-se, nesta proposta, tanto documentos de registros, tais como atas e cadernos de finanças, como partituras do coro de mulheres e artigos artesanais produzidos pela associação, bem como entrevistas concedidas por ex-integrantes. Por meio do estudo de tais documentos sobre essas mulheres, buscou-se investigar a possibilidade de uma contribuição para uma caracterização de uma cultura socioeducacional na cidade de São João da Boa Vista na primeira metade do século XX.

Made available in DSpace on 2014-12-17T15:06:57Z (GMT). No. of bitstreams: 1 CorinaSlLA_DISSERT.pdf: 4457097 bytes, checksum: b08a35b51a624823bd3e71197a8f4c09 (MD5) Previous issue date: 2012-03-16 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / Nowadays, technology has a direct influence on the relationship student and teacher have with language. The internet is a powerful tool in helping work with the language and, through it, the knowledge comes to the student easily and intensely. Furthermore, this facility has enhanced and made visible what has been called, within the University community, "plagiarism generation." This work assumes that this generation has, in their written texts, symbolic movements similar to those of "copy and paste" applied to research work carried out by high school students. Taking this as starting point, this dissertation aims to analyze how high school students of the 1st year from a school in Natal (RN) construct texts, under the movements known as "Ctrl + c" and "Ctrl + v", with reference to the text of the "other". More specific issues are behind the general objective, namely: 1. how the student appropriates the source-text when he copies and pastes? 2. What are the categories of analysis that allow us to look analytically and theoretically for the "ctrl + c / ctrl + v" practice made by the student? 2. how the studies developed in the fields of "Genetic Criticism" (Gr?sillon, 1987), the "school manuscripts" (Calil, 2004) and "paraphrase" (Fuchs, 1982) may help in working with writing in the classroom standing as a possible way to minimize the copy and paste effects in the students texts? Thus, we observe the categories of analysis that allow us to look, theoretically and analytically, for the symbolic ritual of the "ctrl + c" (copy) and "ctrl + v" (paste) in high school. Our study shows that the student text is a "hybrid body" whose writing is a drawing entanglement because of the presence of the foreign text, verbatim, and the presence of linguistic elements to paraphrase the original text.This textual embodiment has, behind it, certain operations, namely: replacing, moving, adding and deleting statements. Given the specificity of the data and the research objectives, this study aligns with qualitative research methods (SILVERMAN, 2009) and falls within the knowledge field of Applied Linguistics, which is characterized especially by investigating problems, phenomena in which language in a real situation is taken as central (BRUMFIT, 1995).Theoretically, our work follows the approach of studies on the paraphrase (Fuchs, 1982, 1994a, 1994b; DAUNAY, 1997, 1999, 2002a, 2002b), the studies developed in the field of Genetic Criticism (Gr?sillon, 1987, 1994, 1992, 2008 ) and those developed by Eduardo Calil (2004) on "school manuscripts" / Na contemporaneidade, a tecnologia mant?m influ?ncia direta na rela??o que aluno e o professor mant?m com a linguagem. A internet ? uma ferramenta poderosa no aux?lio do trabalho com a linguagem e, atrav?s dela, o conhecimento chega ao aluno de forma f?cil e intensa. Por outro lado, essa facilidade potencializou e deixou ? vista o que se tem chamado, na Universidade, de a gera??o do pl?gio . Esse trabalho parte do princ?pio de que essa gera??o apresenta, em seus textos escritos, movimentos simb?licos similares ?queles de copiar e colar recorrentes em trabalhos de pesquisa desenvolvidos por alunos do ensino m?dio. Tomando essa quest?o como inicial, esta disserta??o tem como objetivo analisar como estudantes do 1? ano de uma escola do ensino m?dio da cidade de Natal (RN) constroem textos, sob os movimentos conhecidos como Ctrl+c e Ctrl+v , tomando como refer?ncia o texto do outro . Quest?es mais espec?ficas encontram-se subjacentes ao objetivo geral, quais sejam: 1. de que modo o aluno se apropria do texto-fonte quando copia e cola? 2. que categorias de an?lise nos permitem olhar anal?tica e teoricamente para a pr?tica do Ctrl+c/Ctrl+v efetuada pelo aluno? 3. de que modo os trabalhos desenvolvidos sob os campos da Cr?tica Gen?tica (GR?SILLON, 1987), dos manuscritos escolares (CALIL, 2004) e da Par?frase (FUCHS, 1982) podem auxiliar no trabalho com a escrita em sala de aula, colocando-se como um caminho poss?vel para minimizar os efeitos do copiar e colar nos textos dos alunos? Assim, observaremos as categorias de an?lise que nos permitem olhar anal?tico e teoricamente para o ritual simb?lico do Ctrl+c (copiar) e Ctrl+v (colar) no ensino m?dio. Nosso estudo mostra que o texto do aluno ? um corpo h?brido , cuja escritura ? um desenho fiado pela presen?a do texto alheio, ipsis litteris, e pela presen?a de elementos lingu?sticos que parafraseiam o texto de origem. Essa corporeidade textual tem, subjacente a ela, certas opera??es, a saber: substitui??o, deslocamento, adi??o e exclus?o de enunciados. Dada a especificidade dos dados e os objetivos do trabalho, esse estudo se alinha aos m?todos da pesquisa qualitativa (SILVERMAN, 2009) e se insere na ?rea de conhecimento da Lingu?stica Aplicada que se caracteriza especialmente por investigar problemas, fen?menos em que a linguagem em uma situa??o real ? tomada como central (BRUMFIT, 1995). Teoricamente, nosso trabalho segue a perspectiva dos estudos sobre a par?frase (FUCHS, 1982, 1994a, 1994b; DAUNAY, 1997, 1999, 2002a, 2002b), dos estudos desenvolvidos no campo da Cr?tica Gen?tica (GR?SILLON, 1987, 1994, 1992, 2008) e aqueles desenvolvidos por Eduardo Calil (2004) sobre os manuscritos escolares

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-10-18T20:27:51Z No. of bitstreams: 1 RudsonDeSouzaLima_TESE.pdf: 3299242 bytes, checksum: 3e308727599cf78da8ad994be49620ac (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-10-23T23:00:51Z (GMT) No. of bitstreams: 1 RudsonDeSouzaLima_TESE.pdf: 3299242 bytes, checksum: 3e308727599cf78da8ad994be49620ac (MD5) / Made available in DSpace on 2017-10-23T23:00:51Z (GMT). No. of bitstreams: 1 RudsonDeSouzaLima_TESE.pdf: 3299242 bytes, checksum: 3e308727599cf78da8ad994be49620ac (MD5) Previous issue date: 2017-06-05 / Diante da realidade mundial de preserva??o ambiental, da necessidade de reaproveitamento de insumos, redu??o de custos e melhoramento de propriedades, tem-se desenvolvido muitas tecnologias que atendam a uma s?rie desses fatores e, se poss?vel, a todos. Nesse sentido, os materiais comp?sitos assumem um papel de destaque nesse desenvolvimento de novos materiais. O PET (Polietileno tereftalato) tem sido muito utilizado pela ind?stria mundial em v?rias aplica??es, onde a principal dessas ? a produ??o de embalagens de produtos de aliment?cios, em que as ind?strias de refrigerantes s?o os grandes consumidores desse produto. J? na linha de fibras naturais, existe uma vasta quantidade de op??es de uso em aplica??es de engenharia (Sisal, carna?ba, algod?o, pia?ava, etc.). Diante do exposto, esse trabalho visa ? produ??o, caracteriza??o (Mec?nicos, t?rmicos e f?sicos) e compara??o de uma s?rie de configura??es de materiais comp?sitos com uma matriz polim?rica (Ep?xi) com refor?o de PET p?s-consumo e pia?ava (Resina ep?xi para refer?ncia; ep?xi com fibras de PET; ep?xi com fibras de pia?ava; e comp?sito h?brido). Os comp?sitos foram produzidos com fibras bidirecionais em forma de tecido, as fibras tinham espa?amento entre elas de 1 cm. Os materiais refor?ados promoveram aumento de algumas propriedades, como flex?o, que apresentou um incremento de cerca de 25% na tens?o m?xima admiss?vel do material. Observou-se que a ordena??o das fibras em sentido unidirecional pode melhorar as resist?ncias mec?nicas do comp?sito, isso porque, de forma geral, todas as rupturas dos ensaios ocorreram em uma sec??o de fragiliza??o provocada pelas fibras transversais aos esfor?os. Quando submetidos a esfor?os mec?nicos, o comp?sito com refor?o/carga de PET apresentou-se como a melhor configura??o, o qual apresentou um m?dulo de elasticidade em regime de flex?o 24% maior que a resina pura. J? em an?lise t?rmica, o comp?sito h?brido apresentou melhores caracter?sticas para isolamento t?rmico, visto que sua condutividade t?rmica reduziu em 2% quando comparado com o ep?xi puro. / Over the world reality of environment preservation, the necessity of reuse supplies, reduction of costs and improvement of properties, it has been developed many technologies that support a series of these factors and, if possible all of them. In this sense, the composite materials assume a special role in the growth of new materials. The PET (polyethylene terephthalate) has been utilized by worldwide industries in many different applications, from which the principal one of them is the packaging of food production, wherefrom the soft drink industries are the most substantial consumer of this product. As for natural fibers research line, there is a vast quantity of options for engineering application handling (Sisal, carnauba, cotton, piassava, etc.) In the face of what has been exposed, this research strives for the production, characterization (Mechanical, thermal and physical) and comparison of a series of configurations in the composite materials with a polymer matrix (Epoxy) with reinforcement of PET after consummation and piassava (epoxy resin for reference; enhancement resin with piassava fibers; and hybrid composite). The composites were produced with bidirectional fibers in a format of tissue, the fibers had spaces between them of 1 centimeter. The reinforced materials promoted increment of some properties, such as flection, that presented an enhancement of nearly 25% of maximum tension admitted in the material. It was observed however, that the ordination of the fibers in a unidirectional way might improve the mechanic resistance of the composite, that?s because, in general form, all the ruptures occur in one section of fragilization provoked by the transversal fibers to the reinforces. While submitted to mechanic reinforces, the composite with reinforce/charge of PET presented itself with an improved configuration, Which showed a modulus of elasticity in a regime of flexion 24% larger than the pure resin. As for the thermal analysis, the hybrid composite presented enriched characteristics for the thermal insulation, since its thermal conductivity reduced by 2% when compared to the pure epoxy.

Submitted by Cássia Santos (cassia.bcufg@gmail.com) on 2015-03-27T14:09:53Z No. of bitstreams: 2 Tese - Mariana Batista Rodrigues Faleiro - 2014.pdf: 5818224 bytes, checksum: a60fa8936047debb466ca6014a330b87 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) / Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2015-03-27T15:47:36Z (GMT) No. of bitstreams: 2 Tese - Mariana Batista Rodrigues Faleiro - 2014.pdf: 5818224 bytes, checksum: a60fa8936047debb466ca6014a330b87 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) / Made available in DSpace on 2015-03-27T15:47:36Z (GMT). No. of bitstreams: 2 Tese - Mariana Batista Rodrigues Faleiro - 2014.pdf: 5818224 bytes, checksum: a60fa8936047debb466ca6014a330b87 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Previous issue date: 2014-11-14 / Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq / Somedysplastic lesionsof prostate, such as proliferativeinflammatoryatrophy (PIA) and prostatic intraepithelial neoplastic(PIN) are proliferative,consideredpremalignant andcan progress toprostatic carcinoma (PC). Others, such asbenign prostatichyperplasia(BPH) are proliferative, butare not related tomalignancy.The humanPC is the one ofcancers that more kill,and dog`sthe onlyanimal species thatpresentsadiseasewith similarcharacteristics, thishas been usedas a modelfor studyof prostatecancer. Thus, in order tobetter understandthe molecular mechanisms involvedin repairand cell cycleevolution ofproliferative lesionsincanine prostate, this study aimed to evaluatethe gene expression ofErbB1, ErbB2, CDKN1A, CDKN1BandTP53andimmunostaining ofEGFR(Her1), Her2(c-erbB-2), p21, p27and p53 inprostateswithPIAandPC. Also was evaluatedtheimmunostaining ofp21, p27, p53, c-myc andcyclinD1inprostateswith BPH, PIA, PINandPC. For this purpose,wereobtained from atissue microarray (TMA)block, 106samplesofcanineprostate tissue, which 15 normal, 16with BPH, 30 withPIA, 20 with PIN, and 25with CP. The RT-PCR andRT-qPCR techniques wereused to evaluategene expression, as well as immunohistochemistrywas used to determinetheimmunophenotypeofprostatic lesions. As forEGFRand Her2has beenobserved that thesereceptorsactin canine lesions withPIA and with PCan importantaction ofHer2, suggesting that theyare involvedin carcinogenesisandtumor development in canineprostate. Regarding to cellcycleinhibitor concludethat whenoverexpressedin canine prostateswithPIAandPC, p21andp27control cellproliferation, acting as a protective factorin the evolution of PIA to PC, and in the PC development, even in the presence of altereted p53. In assessing ofimmunostaining ofcell cycle regulators(p21, p27, p53, cyclinD1andc-myc) in canineprostateswithproliferative lesionswas observedthatcarcinomas probably have lowgrowth potentialwhenoverexpressed of p21andp27, reduced expression of cyclinD1and unalteredexpression ofc-myc, even in the presence ofmutant p53type.Further,considering thesimilarimmunophenotypein canine glands with PIA, PINandPC considered the regulatorsofcell cycle progression, it is reinforce the pre-malignant potential of PIA andPINin the canineprostate. / Algumas lesões displásicas da próstata, como a atrofia inflamatória proliferativa (PIA) e a neoplasia intraepitelial prostática (PIN), são proliferativas, consideradas pré-malignas e podem evoluir para carcinoma prostático (PC). Outras, como a hiperplasia prostática benigna (HPB), apesar de proliferativas, não possuem relação com malignidade. Sendo o PC humano uma das neoplasias que mais matam, e o cão aúnica espécie animal que apresenta a enfermidade com características semelhantes, esta tem sido utilizada como modelo para o estudo do câncer de próstata. Assim, com o intuito de melhor compreender os mecanismos moleculares envolvidos na regulação do ciclo celular e evolução das lesões proliferativas na próstata canina, este estudo teve por objetivo avaliar a expressão gênica de ErbB1, ErbB2, CDKN1A, CDKN1B e TP53,e imunomarcação deEGFR (Her1), Her2 (c-erbB-2), p21, p27 e p53 em próstatas com PIA e PC. Também foi avaliada a imunomarcação de p21, p27, p53, cmyc e cyclin D1 em próstatas com HPB, PIA, PIN e PC. Para tal, foram obtidas de um bloco de microarranjo tecidual (TMA) 106 amostras de tecido prostático canino, sendo 15 normais, 16com HBP, 30com PIA, 20com PIN, e25com PC. As técnicas de RT-PCR e RT-qPCR foram empregadas na avaliação da expressão gênica, assim como a técnica de imunoistoquímica foi utilizada para verificar o imunofenótipo das lesões prostáticas. Quanto aos receptores EGFReHer2 foi observado que esses atuam naslesões de PIAePCcanino, com ação importante do receptor Her2, sugerindoqueessesestão envolvidosna carcinogênese e no desenvolvimentotumoral da prostata canina.Em relação aos inibidores do ciclo celular councluiu-se que quando superexpressos em próstatas com PIA e PC, p21 e p27 controlam a proliferação celular, atuando comofator protetivo na evolução da PIA para PC, e no desenvolviemento do PC, mesmo quando da alteração de p53. Na avaliação da imunoexpressão dos reguladores do ciclo celular (p21, p27, p53, ciclina D1 e c-myc) em próstatas caninas com lesões proliferativas foi constatado que os carcinomas possivelmente apresentam baixo potencial de crescimento quando da superexpressãop21 ep27, menor subexpressão de ciclina D1e expressão inalterada de c-myc, mesmo na presença de p53 tipo mutante. Ainda, considerando o imunofenótipo semelhante nas glândulas com PIA, PIN e PC no que se refere aos reguladores daprogressão do ciclo celular, reforça o potencial prémaligno da PIA e PIN na próstata canina.

This work deals with theoretical and practical basis for the creation of converter between LaTeX and Microsoft PowerPoint presentations. It discusses the use of LaTeX and the Beamer class for presentations, programmatic creation of PowerPoint documents using PowerPoint Primary Interop Assemblies and PresentationML. It outlines the use of the scanners and parsers generators GPLEX and GPPG respectively. It deals with the characteristics of today's tools for document conversion. And finally deals with the particular pitfalls of the design, implementation and testing of the application for conversion of documents between LaTeX platform and Microsoft PowerPoint.

För att vara konkurrenskraftig i dagens tillverkningsindustri är ständiga förbättringar essentiella. Därför är lägre priser, lägre ledtider och högre kvalitet en nödvändighet för att kunna konkurrera i dagens marknad. Målet med studien baseras på de frågeställningar som fallföretaget har presenterat, där ledtiderna var långa, PIA-nivåerna var höga och eventuella flaskhalsar satte stopp för produktionens fulla prestanda. Målet var då att hitta lösningar för att optimera produktionsflödet med hjälp av implementering av Lean-verktyg. Studiens resultat tyder på att kommunikation mellan processerna i produktionen samt lägre batchstorlekar kan förbättra flödet i produktionen. / In order to be competitive in today's manufacturing industry, continuous improvements are essential. Therefore lower prices, lower lead times and higher quality is a necessity to be able to compete in today's market.  The goal of the study was based on issues at the case company, where lead times were long, WIP levels were high and possible bottlenecks put a stop to the full performance of the production. The goal was then set to find solutions to optimize the production flow with the help of the implementation of Lean tools. The results of the study indicate that communication between the processes in the production as well as lower batch sizes can improve the flow of the production.

Made available in DSpace on 2014-07-29T15:07:55Z (GMT). No. of bitstreams: 1 dissertacao mariana faleiro part 1.pdf: 60728 bytes, checksum: 82e5bf30cd60c4752f1de660f88797ed (MD5) Previous issue date: 2010-03-02 / Humans and dogs show dysplastic lesions in the prostate, such as prostatic intraepithelial neoplasms (PIN) and proliferative inflammatory atrophy (PIA), which are studied due to their malignance potential. The matrix metalloproteinases (MMP) are a family of proteolytic enzymes thought to play an important role in tumor invasion and metastasis in face of their ability to degrade the extracellular matrix (ECM) and basement membrane. The plasminogen activator (PA) system has been suggested to play a central role in cell adhesion, migration, wound healing, angiogenesis, inflammation, regulation of growth factors and tumor invasion. The receptor of plasminogen activator type activator (uPAR) is a component of the PA, with a range of expression in tumor cell and stromal cells. So, this study was aimed to evaluated the expression and correlation between MMP-2 (gelatinase A) and MMP-9 (gelatinase B) as well as the expression of uPAR in normal canine prostate tissue and also in tissue with proliferative disorders, including benign prostatic hyperplasia (HPB), PIA, PIN and carcinoma. And therefore establish relation among the role of these enzymes in the remodeling of the extracellular matrix (ECM) and in the process of tumor invasion and metastasis. For this, it was performed immunohistochemical staining in tissue microarray of 149 paraffin-embedded fragments of prostate tissue selected from 57 prostates of non-castrated adult dogs with or without prostatic diseases. A total of 298 cores were analyzed and it was made 363 diagnoses: 36 (9.9%) normal, 49 (13.5%) BPH, 132 (36.3%) PIA, 75 (20.7%) PIN and 71 (19.6%) carcinomas. It was observed differences in cytoplasmatic immunohistochemical staining by MMP-2 and MMP-9 antibodies in relation to the cell number and intensity of labeling of the acinar epithelial and stromal perilobular cells between normal tissue and in those with proliferative disorders. A correlation between MMP-2 and MMP-9 antibodies occurred just in canine prostates with PIA in relation to the number of labeled cells in acinar epithelium and perilobular stroma, as well as, the staining intensity in the perilobular stromal cells. In relation to uPAR, it was observed differences of immunohistochemical staining of uPAR antibodies in canine prostate. Likewise, there was over expression in dysplastic and neoplasic specimens, but not in normal and benign prostate tissue. A number of epithelial cells labeled for uPAR showed variation among the diagnoses, except between PIN and carcinoma. Less intensity of labeling was observed in acinar epithelial cells of normal prostates compared with PIA, PIN and carcinoma. However, in the normal cells and in those with PIA, there was a difference in the number of cells, as well as in the intensity of stromal labeling. The intensity of labeling of stromal perilobular cells was higher in the PIA. PIA-A (accentuated) and PIA-M (moderated) cells showed greater intensity staining stroma and stromal cells labeled for uPAR, respectively. Thus, this study concludes that there was variation in gelatinases and uPAR expression in canine prostate according to the lesion. Also, there was Less labeling in normal and BPH and higher in PIA, PIN and carcinoma prostate tissues. The correlation between MMP-2 and MMP-9 in canine prostates with PIA indicates that the inflammation likely influenced the activity of these enzymes with simultaneous increase in their expression. The uPAR high expression in inflammatory and neoplasic tissues suggests high ECM proteolytic activity in these situations / Nas espécies humana e canina lesões displásicas da próstata, como a neoplasia intra-epitelial prostática (PIN) e a atrofia inflamatória proliferativa (PIA), são estudadas quanto ao potencial de malignidade. As metaloproteinases (MMP) são enzimas proteolíticas envolvidas no processo de invasão tumoral e metástase, causando destruição de barreiras biológicas como a matriz extracelular (MEC) e a membrana basal (MB). O sistema ativador de plasminogênio (PA) compreende proteínas com ação na adesão celular, regulação da migração, cicatrização, angiogênese, inflamação, regulação de fatores de crescimento e invasão tumoral. O receptor de ativador de plasminogênio tipo uroquinase (uPAR) é um dos componentes do PA, com variação de expressão em células neoplásicas e estromais. Este trabalho teve por objetivo verificar a expressão e a correlação entre MMP-2 e MMP-9, assim como a expressão do uPAR no tecido prostático canino normal e com alterações proliferativas, incluindo a hiperplasia prostática benigna (HPB), a PIA, a PIN e o carcinoma, buscando avaliar o papel dessas proteínas no remodelamento da MEC e no processo de invasão tumoral e metástase. Para isso, foi realizada a imunoistoquímica em lâminas de microarranjo tecidual (TMA), com 149 cores selecionadas de 57 próstatas de cães adultos, não castrados, com ou sem histórico de afecções prostáticas. Foram analisados, para cada anticorpo, 298 cores, perfazendo 363 diagnósticos, sendo 36 (9,9%) normais, 49 (13,5%) HPB, 132 (36,3%) PIA, 75 (20,7%) PIN e 71 (19,6%) carcinomas. Foi possível observar diferença de imunomarcação citoplasmática de MMP-2 e MMP-9 em relação ao número de células e intensidade de imunomarcação nas células epiteliais acinares e estromais periacinares em relação aos diagnósticos. A correlação entre os anticorpos MMP-2 e MMP-9 ocorreu em próstatas caninas com PIA quanto ao número de células imunomarcadas no epitélio acinar e no estroma periacinar, bem como quanto à intensidade de imunomarcação nas células estromais periacinares. Quanto ao uPAR, houve diferença na imunomarcação em relação ao diagnóstico, com maior expressão nas displásicas e neoplásicas em relação ás normais e com HPB. O número de células epiteliais imunomarcadas para uPAR variou entre os diagnósticos, exceto entre PIN e carcinoma. Menor intensidade de imunomarcação epitelial foi constatada nas próstatas normais em relação às com PIA, PIN e carcinoma. Entre as normais e com PIA houve diferença no número de células e intensidade de imunomarcação estromal. A intensidade de imunomarcação estromal foi maior nas com PIA. As PIA-M (inflamação moderada) e PIA-A (inflamação acentuada) apresentaram maior intensidade de imunomarcação estromal e células estromais imunomarcadas para uPAR, respectivamente. Concluiu-se que há variação na expressão das gelatinases e do uPAR na próstata canina, de acordo com a lesão, com menor expressão nas normais e com HPB e maior naquelas com PIA, PIN e carcinoma. A correlação entre MMP-2 e MMP-9 em próstatas caninas com PIA indica que a inflamação influencia a atividade dessas enzimas, com aumento simultâneo na expressão de ambas no microambiente inflamatório. Ainda, o aumento na expressão do uPAR nos microambientes inflamatório e neoplásico sugere maior atividade proteolítica na MEC nesses casos

Submitted by Sandra Pereira (srpereira@ufrrj.br) on 2017-06-27T13:04:09Z No. of bitstreams: 1 2010 - Alda Let?cia da Silva Santos Resende.pdf: 1570108 bytes, checksum: 847c87000cc34b478e835aa1e6f258ba (MD5) / Made available in DSpace on 2017-06-27T13:04:09Z (GMT). No. of bitstreams: 1 2010 - Alda Let?cia da Silva Santos Resende.pdf: 1570108 bytes, checksum: 847c87000cc34b478e835aa1e6f258ba (MD5) Previous issue date: 2010-06-08 / Once fish product offering by means of extractivism became stable, aquaculture emerges as a viable alternative to the increasing demand for quality protein. Brazilian low consumption of fish meat can be explained not only by cultural factors, but also by low offer of processed products as well as lack of practicity in meal preparation. In industry, after tilapia filleting, mechanically separated meat (MSM) is obtained which can be used for manufacturing of products with higher aggregated value. This work aimed at studying the technical feasibility, nutritional and sensorial qualities of tilapia fillet both in preserves and p?t? based on MSM, where protein and fatty acid profile alterations are observed. Simultaneously, a study on p?t? life span was carried out for a 180-days' period. Time x temperature binomial used (115?C x 20 minutes, and 115?C x 15 minutes, for the tilapia fillet and p?t?, respectively), were sufficent for assuring the commercial sterility of products. In relation to the preserved fillet, the most acceptable formula was of brine at 3%, and addition of fish seasoning to the covering oil, resulting in acceptance of 49%; 82%; 88%, and 65% for the attibutes: ?appearance?, ?taste?, ?texture? and for the purchasing intention, respectively. Both fatty acids EPA (Eicosapentaenoic) and DHA (docosaenoic) values were of 0.04% and 0.86%, respectively, while the sum of fatty acids series ?3 was equal to 0.34 g/100 g. Content of cholesterol was of 40.63 mg/100 g, considered low when compared to other products, such as eggs and meat. Physicalchemical composition of the product was: moisture: 76.21%; protein: 16.18%; ashes: 1.45%; ethereal extract: 3.71%. In relation to the p?t?, the storing period studied did not alter either the protein or the fatty acids profile, nor was the physical-chemical composition significantly alterated (moisture: 61.05%; protein: 9.44%; ashes: 2.41%; ethereal extract: 19.45%). By means of Quantitative Descriptive Analysis (QDA) a significant variation (P<0.05) was observed only on the averages attributed to ?spreadability? and ?creamy quality? throughout the study. Although ethereal extract in p?t? was high, cholesterol content was low (38.68 mg/100 g) taking into account that canoil oil was used in its formula, which not compromised quality of fatty acids profiled. DHA and linoleic acid values of p?t? were 0.35 and 5.60, respectively, and the sum of series ?3 fatty acids was of 1.58 g/100 g. After 180-day storing, acceptance frequency by consummers was of 95% for the ?global impression?; 91% for ?taste?; 89% for ?spreadability?, and 80% for ?appearance?. This study proves the technical, nutritional and market potential for products based on Tilapia meat. / Com a estabiliza??o da oferta de produtos de pesca pelo extrativismo, a aquicultura se mostra como alternativa vi?vel ao atendimento da demanda crescente por prote?na de qualidade. O baixo consumo brasileiro da carne de pescado pode ser explicado por fatores culturais, mas tamb?m pela baixa oferta de produtos processados e pela falta de praticidade no preparo da refei??o. Na ind?stria, ap?s o processo de filetagem da Til?pia, obt?m-se com aux?lio de m?quina despolpadeira, a carne mecanicamente separada (CMS) que pode ser utilizada na fabrica??o de produtos com maior valor agregado. Este trabalho teve como objetivo estudar a viabilidade t?cnica, qualidade nutricional e sensorial do fil? de Til?pia em conserva e do pat? ? base da CMS, observando as altera??es no perfil prot?ico e de ?cidos graxos. Foi realizado tamb?m estudo de vida ?til do pat? por per?odo de 180 dias. Os bin?mios tempo x temperatura utilizados (115?C x 20 minutos e 115?C x 15 minutos, para fil? e pat? de Til?pia, respectivamente), foram suficientes para garantir a esterilidade comercial dos produtos. Em rela??o ao fil? em conserva, a formula??o que obteve maior aceita??o foi a de salmoura a 3% e com tempero para peixe no ?leo de cobertura na qual a frequ?ncia de aceita??o do mesmo foi de 49%; 82%; 88% e 65% para os atributos ?apar?ncia?, ?sabor?, ?textura? e para a inten??o de compra, respectivamente. Os valores de ?cidos graxos EPA (eicosapentan?ico) e DHA (docosaexan?ico) foram de 0,04% e 0,86%, respectivamente e o somat?rio de ?cidos graxos da s?rie ?3 igual a 0,34 g/100 g. O teor de colesterol do produto foi de 40,63 mg/100 g sendo considerado baixo quando comparado ? outros alimentos como ovos e carnes. A composi??o f?sico-qu?mica do produto foi: umidade: 76,21%; prote?na: 16,18%; cinzas: 1,45%; extrato et?reo: 3,71%. Em rela??o ao pat?, o per?odo de armazenamento estudado n?o alterou o perfil prot?ico nem o de ?cidos graxos do produto, al?m de n?o ter alterado de forma significativa a sua composi??o f?sico-qu?mica (umidade: 61,05%; prote?na: 9,44%; cinzas: 2,41%; extrato et?reo: 19,45%). Atrav?s da An?lise Descritiva Quantitativa (ADQ) foi observada varia??o significativa (p<0,05) somente das m?dias dos atributos ?espalhabilidade? e ?cremosidade? ao longo do estudo. Apesar do teor de extrato et?reo do pat? ser elevado, o teor de colesterol foi reduzido (38,68 mg/100 g) visto que foi usado ?leo de canola na sua formula??o, o que tamb?m n?o comprometeu a qualidade do perfil de ?cidos graxos do mesmo. Os valores de DHA e ?cido linol?nico do pat? foram 0,35 e 5,60%, respectivamente e o somat?rio dos ?cidos graxos da s?rie ?3 foi de 1,58 g/100 g. Ap?s 180 dias de armazenamento, a frequ?ncia de aceita??o do pat? entre os consumidores foi de 95% para a ?impress?o global?; de 91% para o atributo ?sabor?; de 89% para a ?espalhabilidade? e de 80% para a ?apar?ncia?. Este estudo comprova o potencial t?cnico, nutricional e de mercado para os produtos ? base de carne de Til?pia.

The purpose of this study was to examine the differences as well as the similarities between the coverage and representation of the coaches of the Swedish men's national team and women's national team. The method we used for our study was quantitative content analysis. We examined 473 articles in the two Swedish tabloid newspapers Aftonbladet and Expressen. Some of the major results that we found in the study were that the representation of the coach of the men's national team were more positive than the women's coach. 76 articles about Jan Andersson, coach for the men's team were positive, while 25 articles about Pia Sundhage, coach for the women's team were positive. We also found out that the men's national team were in far more articles than the women's team. 340 articles were about the men's team and 133 articles were about the women's team.