The present study characterized the deep-sea gastropods community collected on whale bones and wood parcels artificially implanted in the deep Southwest Atlantic Ocean at 1500 and 3300 m depth for 23 months. A total of 5493 gastropods were collected and their distribution, abundance and diversity on substrates, depths and latitudes were calculated. Species richness and abundance of gastropods were higher in whale bones and deeper sites. Latitude did not seem to influence the distribution of mollusks. Five species were selected due to their abundance and possible ecological importance for further studies. Three were new species of the superfamily Abyssochrisoidea and were morphologically and genetically described (two Rubyspira and one Cordesia). The other two were Hyslogyrina rissoela (Heterobranchia) and Lusitanops cingulatus (Neogastropoda). To understand their feeding behavior and dispersal strategies were conduced stable isotopes analyzes, observations of gut content, and radular and larval shell morphology. Larval shell of most species suggested planktotrophic development. Animals on different growth stages were found. Gastropods presented a diversity of feeding strategies, such as bacterial mats grazing, predation and specialized bone eating. The overlap of this fauna with other chemosynthetic environments and with other basins corroborate with the ecological stepping stone hypothesis. Besides that, phylogenetic studies about Abyssochrysoidea were made. Their phylogenetic position within the Caenogastropoda are still uncertain but this group is considered closely related with Littorinidae. These snails are endemic from chemosynthetic environments, such as deep-sea hydrothermal vents, cold seeps and organic falls in the deep-sea. The genus Rubyspira is not settled at family level and no molecular studies were made for Cordesia. The present study also attempts to assign these groups phylogenetically. Concatenated COI, 16S, 18S and 28S and individual gene trees were constructed for maximum likelihood and Bayesian analysis. In all analyses the family Newtoniellidae were a sister group of Abyssochrysoidea. Morphological and genetic evidences suggest that Rubyspira and Cordesia are closer related to Abyssochrysos than to other provannid snails. The most accepted hypothesis is that Provannidae is paraphyletic. However, there are other ideas that indicates Rubyspira and Cordesia could be included in Abyssochrysidae or the Provannidae should be considered Abyssochrysidae. A morphologic revision of the superfamily should be made to better understand the relation within the group. Clades within the Abyssochrysoidea were always well supported and similar to those found in the literature. The position of Rubyspira and Cordesia within Abyssochrysoidea suggest whale bones and wood parcels did not play an evolutionary role as stepping stones for this group. / O presente estudo caracterizou a comunidade de gastrópodes de mar profundo coletados em carcaças de baleia e parcelas de madeira artificialmente implantadas no Sudoeste do Oceano Atlântico profundo a 1500 e 3300 m de profundidade por 23 meses. Um total de 5493 gastrópodes foram coletados e sua distribuição, abundância e biodiversidade nos substratos, profundidades e latitudes foram calculados. A riqueza e abundância dos gastrópodes foi maior nos ossos de baleia e em maiores profundidades. A latitude parece não ter influenciado na distribuição dos moluscos. Cinco espécies foram selecionadas devido à abundância e possível importância ecológica. Três são novas espécies da superfamília Abyssochrysoidea que foram descritas morfologicamente e filogeneticamente (duas Rubyspira e uma Cordesia). As outras duas foram Hyalogirina rissoela (Heterobranchia) e Lusitanops cingulatus (Neogastropoda). Para compreender os hábitos alimentares e de dispersão desses animais análises de isótopos estáveis, observações do conteúdo do trato digestório, da morfologia das rádulas e das conchas larvais foram realizadas. A concha larval da maioria das espécies sugere um desenvolvimento planctotrófico. Os moluscos encontrados apresentaram diversos tipos de hábitos alimentares como raspadores de carpete bacteriano, predadores e especialistas de ossos. A sobreposição dessa fauna com a de outros ambientes quimiossintéticos e de outras bacias oceânicas colabora com a hipótese ecológica das \"stepping stones\" no mar profundo. Além disso, estudos sobre a posição filogenética dos Abyssochrysoidea foi feita. Sua posição nos Caenogastropoda ainda é incerta, mas são considerados próximos aos Littorinidae. Esses animais são endêmicos de ambientes quimiossintéticos, como fontes hidrotermais de mar profundo, fontes frias e quedas orgânicas. O gênero Rubyspira não está atribuído à nenhuma Família e não foram realizados estudos moleculares para Cordesia. Esse estudo também tenta organizar esses grupos filogeneticamente. Árvores concatenadas e individuais dos genes COI, 16S, 18S e 28S foram construídas para máxima verossimilhança e análise bayesiana. Em todos resultados a família Newtoniellidae foi um grupo irmão dos Abyssochrysoidea. Evidências morfológicas e genéticas s para que sugerem que Rubyspira e Cordesia então mais próximos dos Abyssochrysos do que de outros provannides. A teoria mais aceita é de que os Provannidae são parafileticos. Porém há outras ideias de que Rubyspira e Cordesia poderiam ser inclusos em Abyssochrysidae, ou que os Provannidae fossem considerados Abyssochrysidae. Uma revisão dessa superfamilia deveria se feita para entender as relações desse grupo. Os clados de Abyssochrysoidea sempre foram bem suportados como na literatura. A posição de Rubyspira e Cordesia nos Abyssochrysoidea. aponta que os ossos de baleia e parcelas de madeira possam não terem servido como \"stepping stones\" evolutivas para esses gastrópodes.

A nefrolitíase é uma doença comum e recorrente com prevalência mundial variando de 5 a 20%, com pico de incidência entre a 3ª e 4ª década de vida e com maior prevalência em homens (3:1), frequentemente associado a atendimento de urgência. O tratamento da litíase ocorre em duas fases. Inicialmente, no episódio agudo de dor pela passagem do cálculo pelas vias urinárias, cujo objetivo terapêutico é o alívio da dor e a expulsão do cálculo. Para aqueles doentes com cálculos de repetição, o objetivo terapêutico será o de reduzir a formação de novos cálculos. Para ambos os objetivos, o arsenal terapêutico disponível é limitado. Estudos pré-clínicos com o Extrato Padronizado de C. langsdorffi - EPC-AF® (Apis-Flora, Ribeirão Preto, Brasil), um composto vegetal extraído da bioflora nacional, mostraram perfil de segurança e eficácia deste composto como potencial medicamento para o tratamento da litíase renal. Desta forma, o objetivo deste estudo foi o de avaliar o perfil de segurança em humanos e eficácia preliminar do EPC-AF®. Foi realizado um estudo clínico fase I/IIa, randomizado, duplo-cego, comparado com placebo, de dose única de forma ascendente. As doses utilizadas foram de 175 mg, 350 mg,700 mg, 1,4 g e 2,8 g administradas por via oral em dose única após jejum de 12h. Foram estudados grupos de 6 voluntários sadios por dose. Em cada grupo, 4 voluntários receberam de forma randomizada e cega o EPC-AF® e 2 voluntários placebo. O escalonamento para doses mais altas foi feito após a comprovação de que não houve eventos adversos com a dose previamente usada. No total, 30 voluntários sadios foram estudados na Unidade de Pesquisa Clínica do HCFMRP-USP. Foram coletados dados clínicos e laboratoriais para segurança, com destaque para toxicidade renal, onde foram estudados variação das concentrações urinárias de NGAL (neutrophil gelatinaseassociated lipocalin), NAG (N-acetyl-beta-D-glucosaminidase), KIM-1 (Kidney injury molecule-1) e alfa-1-microglobulina, além da dosagem sérica de cistatina C, um marcador da taxa de filtração glomerular. Os dados de eficácia preliminar foramcentrados na análise do perfil bioquímico urinário (pH, cálcio, citrato, oxalato, ácido úrico, magnésio e fosforo) em amostras de urina de 24h, coletadas antes e imediatamente após o uso de EPC-AF® ou placebo. Os resultados obtidos mostraram que o EPC-AF® é seguro nas doses de 175 a 2,8 g por via oral. Não foi observada variações significativas das concentrações de 24h dos principais componentes facilitadores ou inibidores da formação de cálculos urinários / Nephrolithiasis is a common and recurrent disease with a worldwide prevalence varying from 5 to 20%, with a incidence peak between the 3rd and 4th decade of life and with a higher prevalence in men than women (3: 1), often associated with urgent care. The treatment of lithiasis occurs in two phases. Firstly, in the acute episode of pain by the passage of the calculus through the urinary tract, whose therapeutic objective is to relieve pain and expel the stone. For those patients with recurrent stones the therapeutic goal will be reducing the formation of new stones. For both objectives, the available therapeutic arsenal is limited. Preclinical studies with C. langsdorffi standard extract (EPC-AF®, Apis-Flora, Ribeirão Preto, Brazil), an herbal compound extracted from a Brazilian native plant, showed a safety and efficacy profile of this compound as a potential drug for the treatment of renal lithiasis. Thus, the objective of this study was to evaluate the safety profile and the preliminary efficacy of EPC-AF® in healthy volunteers. A phase I/IIa clinical trial, randomized, double-blinded, placebocontrolled single-ascending dose was conducted. The doses used were 175 mg, 350 mg, 700 mg, 1.4 g and 2.8 g administered orally in a single dose after 12 h fasting. Groups of 6 healthy volunteers per dose were studied. In each group, 4 volunteers randomly and blindly received EPC-AF® and 2 volunteers received placebo. The escalation to higher doses was done after the confirmation that there were no adverse events with the dose previously used. In total, 30 healthy volunteers were studied on the General Clinical Research Centre of local teaching Hospital. Clinical and laboratory data were collected for safety, with emphasis on renal toxicity, where urinary concentrations of NGAL (neutrophil gelatinase-associated lipocalin), NAG (N-acetylbeta-D-glucosaminidase), KIM-1 (Kidney injury molecule-1) and alpha-1-microglobulin were measured, in addition to serum cystatin C, a marker of the glomerular filtration rate. Preliminary efficacy data were centered on urinary biochemical profile analysis (pH, calcium, citrate, oxalate, uric acid, magnesium and phosphorus) in 24-hour urinesamples collected before and immediately after use of EPC-AF® or placebo. The results showed that EPC-AF® is safe in doses of 175 to 2.8 g orally. No significant variations in 24-h concentrations of the major components facilitating or inhibiting the formation of urinary stones were observed

Submitted by Rosimeri Vergara (rosimerivergara@unipampa.edu.br) on 2017-08-31T23:57:28Z No. of bitstreams: 1 Estudo do rejeito da lavra de rochas ornamentais do Espírito Santo para a produção de brita.pdf: 4958816 bytes, checksum: b0c279e58202890e8ee931ff51d6332c (MD5) / Approved for entry into archive by Marcos Anselmo (marcos.anselmo@unipampa.edu.br) on 2017-09-12T20:15:08Z (GMT) No. of bitstreams: 1 Estudo do rejeito da lavra de rochas ornamentais do Espírito Santo para a produção de brita.pdf: 4958816 bytes, checksum: b0c279e58202890e8ee931ff51d6332c (MD5) / Made available in DSpace on 2017-09-12T20:15:08Z (GMT). No. of bitstreams: 1 Estudo do rejeito da lavra de rochas ornamentais do Espírito Santo para a produção de brita.pdf: 4958816 bytes, checksum: b0c279e58202890e8ee931ff51d6332c (MD5) Previous issue date: 2016 / Agência 2 / O Brasil é um importante produtor de rochas ornamentais no cenário mundial. O Estado do Espírito Santo (ES) tornou-se referência mundial em mármore e granito, além de destacar como líder absoluto na produção nacional de rochas com investimentos do parque industrial brasileiro no setor de rochas ornamentais com mais de 600 jazidas ativas de granito, produzindo até 500 tipos diversificados deste produto. Toda esta produção gera um volume considerável de rejeitos, que são depositados em pilhas, tornando-se um passivo ambiental. Esses rejeitos são gerados na abertura da pedreira, e principalmente durante o desenvolvimento das bancadas, devido ao descarte de blocos considerados fora das especificações de mercado ou ainda blocos com defeitos, tais como presença de fraturas e trincas, tanto as de origem tectônica, quanto as resultantes das fases críticas das operações de lavra, assim como no manejo de explosivos, tombamento de painéis, manuseio dos blocos e principalmente devido ao alívio das tensões internas das rochas. O objetivo geral desta pesquisa é caracterizar os rejeitos grosseiros provenientes da lavra de rochas ornamentais, buscando uma aplicação na construção civil. A metodologia utilizada foi um estudo de caso, caracterizando dois rejeitos de duas empresas situadas no noroeste do estado do Espírito Santo. Para esta caracterização utilizou-se algumas técnicas de caracterização geológica como descrição microscópica e fluorescência de raios X, além de ensaios de caracterização do agregado, como britagem, peneiramento, abrasão los angeles e compressão uniaxial. Cabe destacar que os resultados peneiramento e compressão uniaxial foram satisfatórios. Concluimos assim, que os rejeitos caracterizados enquadram-se parcialmente nas especificações mercadológicas, deixando assim base para futuras aplicações na indústria. / Brazil is a major producer of ornamental stones on the world stage. The State of Espírito Santo (ES) has become a world reference in marble and granite, and stand out as the absolute leader in the national production of rocks by the Brazilian industrial park investment in the ornamental stones sector with more than 600 active mines (quarries) of granite, producing up to 500 types diversified of this product. This huge production generates a considerable amount of waste (rock blocks) that are deposited in piles, becoming an environmental liability. These wastes are generated at the opening of the quarry, and especially during the development of the benches due to the disposal of blocks considered outside of market specifications or blocks with defects such as the presence of fractures and cracks, both of the tectonic origin ones, as the ones resulting from the critical phases of mining operations, as well as in handling of explosives, tipping of the panels, handling of blocks and mainly due to the relief of the internal stresses of the rocks. The objective of this research is to characterize the coarse wastes from the mining of ornamental stones, seeking an application in construction. The methodology used was a case study, featuring two wastes for two companies located in the northwest of the State of Espírito Santo. For this characterization was used some geological characterization techniques such as microscopic description, X-ray fluorescence, and aggregate characterization tests, such as crushing, screening, and Los Angeles Abrasion uniaxial compression. It should be noted that the sieving and uniaxial compression results were satisfactory. We conclude therefore, that the tailings characterized fit partially in the marketing specifications, thus leaving a basis for future applications in industry.

O polimento das rochas ornamentais é um processo realizado com o uso de rebolos abrasivos que desgastam a superfície da chapa até atingir uma intensidade de brilho comercialmente desejável. Esse sistema pode ser abordado, de forma racional, pelo enfoque dado pela Tribologia, considerando o atrito e o desgaste como resultado direto da interação entre as rochas e ferramentas abrasivas, de acordo com cada situação operacional adotada. Essa abordagem foi utilizada na presente pesquisa, com o objetivo de tentar validar a metodologia de desenvolvimento de um novo abrasivo de polimento, composta pela resina poliuretana à base óleo de mamona (Ricinus Comunnis L.), cargas sólidas e com o carbeto de silício verde como elemento de corte. Foram avaliados o desempenho destes rebolos frente ao polimento com os rebolos industriais em uma politriz semiautomática, pela análise da taxa de desgaste das peças em função da qualidade do brilho final do polimento. Para isto, foram adotadas condições operacionais que não são praticadas pela indústria, como a variação da velocidade de rotação dos rebolos e variação da vazão de água no polimento. Os resultados mostraram que a proposta de incorporação do carbeto de silício verde como elemento de corte nas matrizes à base resina de mamona à não promoveu um bom desempenho do rebolo, porém com taxas de desgaste equivalentes às matrizes comerciais à base de resina epóxi, demonstrando o potencial de utilização desta resina na fabricação de rebolos abrasivos diamantados. A variação dos parâmetros operacionais de polimento permitiu saber que os melhores resultados se deram com a redução da vazão de água no polimento de 30 para 15 litros, apresentando maiores valores de brilho e com um menor desgaste dos rebolos. Esses dados indicam que esse parâmetro pode ser aplicado na indústria com consideráveis ganhos ambientais para a cadeia produtiva de rochas ornamentais. Neste âmbito, a utilização de uma ferramenta ecoeficiente, comprovadamente atóxica, no polimento de rochas ornamentais pode ser um grande passo para a obtenção de certificados internacionais de comércio de produtos com forte apelo ambiental. / The polishing of dimension stones is a process carried out using abrasive fickerts which wear the surface of the slab to achieve a commercially desirable brightness intensity. This system can be approached in a rational way by the concepts given by Tribology, considering the friction and wear as a direct result of the interaction between the stone and the abrasive tools, according to each operational situation adopted. This approach was used in the present research, aiming the validation of a methodology for development a new polishing tool, composed of polyurethane resin based on the castor oil (Ricinus Comunnis L.), solid fillers and the green silicon carbide as cutting element. The performance of these new abrasive fickerts compared with the industrial ones was evaluated in a semiautomatic polishing machine by the analysis of the wear rate of the pieces as a function of the final gloss quality of the polished surface. For this purpose, operating conditions not practiced in the industry was adopted, as the rotational speed of the abrasive tools and the water flow variation. The results showed that the incorporation of the green silicon carbide as a cutting element in the matrix based on the resin of castor oil did not promote a good performance of the tool, but with wear rates equivalent to the commercial epoxy-resin fickerts, which may indicate a potential of using the non-toxic matrix with diamond as cutting element instead. The variation of the operational parameters of polishing allowed to know that the best results were obtained with the reduction of the water flow in the polish from 30 to 15 liters/minute, which presented higher values of gloss and with a lower wear rate of the tools, indicating that this parameter can be applied in the industry with considerable environmental gains for the dimension stone production chain. In this context, the use of a non-toxic and eco-efficient tool in the polishing of dimension stones can be a great step towards obtaining international certificates of trade in products with strong environmental appeal.

<p>Almost everyday we can read about or listen to the radio the creation of a new company, which is of course successfull and just started several months ago. One succeed but for how many other failures. In our everyday life we only know the companies which exist. We never consider all the high number of companies that have failed. In addition to that, by analyzing some cases, we can notice that some"good"companies, with good team, good concept can failed too. In order to understand the views that exist, one needs to elucidate this problem. The early stage of a new-created company is the most important phase of the firm´s life, according to the fact that it will determine the evolution of its whole structure, and therefore will deeply affect its future. All the more so a firm in order to be successful must be able to growth in the long run. With this thesis, we hope to contribute to a better understanding of the key- success factors ofyoung companies. Therefore we will try to clarify issues concerning this early stage. In particular we will highlight and describe that the early development in a firm is a very important phase in its life. And to determine which factors must be take in consideration in order to avoid future difficulties.</p>

Almost everyday we can read about or listen to the radio the creation of a new company, which is of course successfull and just started several months ago. One succeed but for how many other failures. In our everyday life we only know the companies which exist. We never consider all the high number of companies that have failed. In addition to that, by analyzing some cases, we can notice that some"good"companies, with good team, good concept can failed too. In order to understand the views that exist, one needs to elucidate this problem. The early stage of a new-created company is the most important phase of the firm´s life, according to the fact that it will determine the evolution of its whole structure, and therefore will deeply affect its future. All the more so a firm in order to be successful must be able to growth in the long run. With this thesis, we hope to contribute to a better understanding of the key- success factors ofyoung companies. Therefore we will try to clarify issues concerning this early stage. In particular we will highlight and describe that the early development in a firm is a very important phase in its life. And to determine which factors must be take in consideration in order to avoid future difficulties.

The aim of this study is to determine what can be known about the people who were able to write runes during the Viking Age. The investigation is based on the runecarvers’ own statements about themselves and their work, which is normally found in the signature or the carver formula of the inscriptions. The material comprises all carver formulas known from primarily Scandinavian Viking-age runic inscriptions, but since most of the inscriptions are found on rune-stones, there is a focus on runecarvers who worked in this material. In the study the form and content of these carver formulas are closely analyzed in different ways. It can for example be shown that the choice of verbs in a carver formula is primarily determined by chronology, which is also reflected in the geographical distribution of different verbs in the material. The study also shows that the carver formula is normally positioned finally in the text, and that the examples of other positions might be determined by the content of the rest of the inscription. In some cases the runic monument is signed by more than one name, which has been interpreted as indicating the existence of workshops. Even if this is true for parts of the material, many of the co-signed stones seem to be the products of carvers who only worked occasionally. An investigation of the personal names and the use of attributes such as patronymic, titles or bynames, shows no difference from the normal Viking-age population, which indicates that the rune-carvers were not members of a special social class. The latter part of the study deals with the relationships between the rune-carver and the sponsor of the runic monument. Special attention is paid to some local carvers in the Mälar Valley in order to determine their social status and the extent of their production of rune-stones. The study shows that some of these carvers belonged to a wealthy group of land-owners with contacts abroad, and many of them have executed about ten rune-stones, often in the vicinity of their own dwellingplace. In conjunction with this, there is also an attempt to see to what extent the writing habits of these local carvers are influenced by more productive and presumably professional carvers. This investigation leads to a re-evaluation of one of the most famous carvers in the district, Åsmund Kåresson, which also has some implications for the picture of how the rune-stone custom was introduced into central Sweden at the beginning of the 11th century.

Die Arbeit will die historische Entwicklung von Grenzfeststellung und -kennzeichnung darstellen und deren Bedeutung für die Rechts- und Vermessungsgeschichte Sachsens würdigen. Die Arbeit gliedert sich in zwei Hauptteile. Der erste Teil liefert einen Üerblick über die Entwicklung und den Gebrauch verschiedener Grenzzeichen zur dauerhaften Festlegung und erkennbaren Bezeichnung von Grenzen. Im zweiten Teil folgt die jeweils chronologische Darstellung der unterschiedlichen Kategorien von Grenzen.

Abstract The primary focus of this research project was an evaluation of the Group Stepping Stones Triple P parenting program for parents of a child with a disability. In addition there was an investigation into the similarities and differences in child behaviour and parenting experience, and program outcomes, for families of children with different developmental disabilities. While the Triple P Positive Parenting Program has an impressive evidence base (Sanders, 1999; Sanders, Markie-Dadds, Tully & Bor, 2000) and research indicates that the standard Stepping Stones Triple P Program is efficacious for different disability groups (Roberts, Mazzucchelli, Studman & Sanders, 2006) and for parents of children with Autistic Spectrum Disorders (Whittingham, Sofronoff, Sheffield & Sanders, 2009), to date the group version of Stepping Stones Triple P has not been comprehensively evaluated, nor the efficacy of the program evaluated when administered concurrently to parents of children with different developmental disabilities. Currently, there is a lack of participant-friendly, evidence-based group parenting programs that can be utilised in a cost-effective manner with all parents of children with disabilities. Many interventions have been designed specifically to cater to the requirements of a particular disability group. While there is some divergence in disability characteristics and in the experience of families of children with different disabilities, there is compelling evidence that many of the most challenging experiences faced by parents of disabled children (such as emotional and behavioural disturbance and delays in skill development) are shared by many disability populations (Raina et al., 2005; Bourke et al., 2008). Consequently there is empirical support for the implementation of a broad, skill-based parenting program for all parents of children with disabilities. The first study in this research project was a randomised controlled trial the Group Stepping Stones Triple P program for parents of children with Autism Spectrum Disorders (ASD), Down syndrome, other intellectual disabilities and Cerebral Palsy. Fifty-two families were included in this trial and were randomly allocated to treatment and wait-list control groups. The results demonstrate significant improvements in child behaviour and parenting difficulties that were maintained at follow-up six months later. For over a third of participants the change in child behaviour and parenting styles was clinically reliable (Jacobsen & Truax, 1991; Evans, Margison & Barkham, 1998). In addition, the majority of parents reported the attainment of their program goals following the intervention. The second study was a comparison of program outcomes for parents from different disability groups. The sample was divided into two groups; parents of children with ASD and parents of children with intellectual and physical disabilities. The results demonstrated significant improvements in child behaviour and parenting difficulties from pre- to post-intervention for both the ASD group and the Intellectual and Physical disability group. For a third of parents in the ASD group and over a third of parents in the Intellectual and Physical disability group, the changes were clinically reliable (Jacobsen & Truax, 1991; Evans et al., 1998). In addition, the means for both groups on the child behaviour, parenting style and parental psychological functioning variables were compared. The results indicated that there were some differences in child behaviour, parenting styles and parent distress between the two groups, and in the program goals set by parents. However, overall the results revealed no systematic differences in treatment outcomes across disability groups, demonstrating that the program was effective for families of children with ASD and families of children with Intellectual and Physical disabilities. Finally, a series of three case evaluations were conducted to examine program outcomes and differences in child behaviour and parenting experiences for the families of a child with ASD, Down syndrome and Cerebral palsy. The results of the case studies revealed significant improvements in child behaviour and parenting styles for all three families, along with high levels of program satisfaction and successful attainment of parenting goals. For all three families these changes in child behaviour and parenting style were clinically reliable (Jacobsen & Truax, 1991; Evans et al., 1998) and maintained at six-month follow up. The results also provided information about the similarities and differences in parenting experiences, child behaviour and program goals across the three disabilities. Overall, this research project has demonstrated that the Group Stepping Stones Triple P program is an effective parenting intervention for challenging behaviour and dysfunctional parenting in families of children with a range of developmental disabilities. The results of this research provide evidence to suggest that mixed disability group format used in the administration of the Group Stepping Stones Triple P program did not preclude positive program outcomes. Finally, the results of this research project indicate that there are many shared parenting experiencing across families of children with different disabilities and that regardless of observed differences in disability characteristics and family experiences, the Group Stepping Stones Triple P program is sufficiently flexible and comprehensive in its scope to meet the needs of families from different disability populations.

Submitted by (edna.saturno@ufrpe.br) on 2016-10-20T16:03:20Z No. of bitstreams: 1 Mucio Veloso de Moarais.pdf: 837045 bytes, checksum: 867f9892acaac56c2811fddaf38aaa4e (MD5) / Made available in DSpace on 2016-10-20T16:03:20Z (GMT). No. of bitstreams: 1 Mucio Veloso de Moarais.pdf: 837045 bytes, checksum: 867f9892acaac56c2811fddaf38aaa4e (MD5) Previous issue date: 2012-02-20 / The present work aimed to conduct a study of clinical, epidemiological and laboratory data of 62 sheep and goats from 2001 up to 2011. During this period, it was found that the disease was predominant in sheep with 83.7% of the animals, while for the caprine, it occurred in 16.3%. The most predominant races in sheep were the Santa Ines, in ovine with 71.7% and SRD, in caprine, with 33.33%. There was a predominance in animals less than three years old. In both species, the highest occurrence was found in the dry season with 67.9%. Most animals (75.8%) were kept under intensive farming, with a diet based on concentrate and forage (88.7%) and 85.5% received mineral supplementation. The predominant clinical signs were apathy, pain, dehydration, conjunctive hyperemic mucosa, tachycardia, tachypnea, anorexia, dysuria and anuria. The mortality rate was very high with 40.3% of the animals dying and 16.1% being sacrificed. In the haemogram, leukocytosis was observed with regenerative deviation to the left in goats, and hyperfibrinogenemia. In serum biochemistry, increased urea and creatinine was found which led the animals to a perspective of azotenia and increase of GGT and CK enzymes. The serum levels of calcium, phosphorus and magnesium, were beyond the normal patterns for the species with low Ca and high P and Mg levels. The findings of urinalysis revealed hematuria in 72.2% of animals with acid pH of urine (44.4%) as well as alkaline (55.56%). In the sedimentoscopy, erythrocytes predominated in 66.6% of the samples, epithelial cells in 66.6% of the samples and crystals of various compositions. Regarding the composition of urolites, it was found that 62.5% was oxalate, 8.32% phosphate and 8.33% penicillin. In the conclusion of this study, it was observed that the obstructive urolithiasis is a disease of poor prognosis and can lead to loss of valuable livestock animals, and therefore, serious losses in production. / Considerando-se a importância clínica e econômica da urolitíase obstrutiva para a produção de pequenos ruminantes, objetivou-se desenvolver um estudo dessa enfermidade em caprinos e ovinos. Para tanto, utilizou-se dados dos prontuários de 62 animais atendidos no período de 2001 a 2011, considerando-se variáveis epidemiológicas, clínicas, urinálise, hemograma, funções hepática, renal e muscular, glicose, perfil sérico de cálcio, fósforo e magnésio, além da análise da composição química dos urólitos, compondo o estudo descritivo. A urolitíase obstrutiva observada em 5,1% dos animais estudados. A espécie ovina foi a mais acometida, assim como as raças Santa Inês e Dorper. A maior ocorrência da doença se deu em animais com menos de três anos, no período seco, criados sob regime intensivo, cuja dieta era a base de concentrados (ad libitum) e forragem. Dos acometidos 43,6% receberam alta, 40,3% foram a óbito e 16,1% foram eutanaziados. Dentre os achados clínicos mais frequentes observou-se alterações da micção; desidratação; congestão das mucosas conjuntivas; sinais de dor; diminuição ou ausência de motilidade ruminal; taquicardia; alterações do comportamento e do apetite e; taquipnéia. Nos exames laboratoriais observou-se leucocitose com desvio à esquerda regenerativo nos caprinos, hiperfibrinogemia, valores da creatinina e da uréia elevados, enzimas GGT e CK também elevadas, hiperglicemia e, níveis de Ca, P e Mg desbalanceados. A urina apresentou-se turva, com hematúria, proteinúria, acidúria e alcalinúria, além de baixa densidade. No tocante a sedimentoscopia observou-se o aumento de hemácias e leucócitos, células do epitélio uretral e renal, além de bactérias. Houve predominância de oxalato na composição dos urólitos, porém 8,33% dos urólitos eram compostos de penicilina. A urolitíase obstrutiva acomete mais animais confinados, alimentados com dietas desbalanceadas a base de concentrado. Os exames laboratoriais mostraram ser importantes para o diagnóstico de urolitíase obstrutiva.