O presente estudo trata dos processos cognitivos na construção do sistema de escrita durante a interação entre crianças em processo de alfabetização por meio do uso de aplicativos de comunicação virtual. Seu objetivo é compreender como tal interação pode favorecer o processo de construção da língua escrita. Baseada no Método Clínico, a coleta de dados foi realizada com alunos de uma turma do 2o ano do Ensino Fundamental de uma escola pública do campo, situada na região Metropolitana de Porto Alegre, durante nove sessões de uso de dois aplicativos nos tablets da escola: o Google Classroom e o Google Hangouts. Sustentada pela teoria da equilibração de Jean Piaget, parte-se de uma proposição teórica inicial pautada em uma visão de que o uso dos aplicativos potencializará os desequilíbrios cognitivos e, portanto, a construção da língua escrita em função do contexto de comunicação. Adotou- se a generalização analítica como estratégia para análise dos dados. A primeira unidade de análise apresenta um panorama com dados sobre o processo de construção da língua escrita de sete sujeitos e sobre os desequilíbrios ocorridos ao longo das sessões. Na segunda unidade, analisa-se como ocorrem os desequilíbrios durante o uso dos aplicativos e quais são as reações dos sujeitos ante as perturbações. Na última unidade, discutem-se as situações desencadeadoras e as circunstâncias para a emergência dos desequilíbrios. Ao final do cruzamento das análises, a proposição teórica é revisada, aprofundando o papel dos desequilíbrios e as condições emergentes para o processo de construção da língua escrita. Conclui-se que as situações de comunicação virtual, seja para uma audiência ou para um interlocutor, potencializam a ocorrência de desequilíbrios, favorecendo o surgimento da necessidade cognitiva e/ou afetiva de compreensão da língua escrita, embora os aplicativos em questão, por si só, não ofereçam as resistências ou os feedbacks necessários ao processo. Os resultados encontrados apontam caminhos para a construção de aplicativos voltados à alfabetização. / The present work is a study of the interaction between children in the early literacy process by using virtual communication apps. It researches the cognitive processes involved in the construction of written language that emerges from this interaction. It aims to understand how such interaction can help the development of writing. Based on the Clinical Method, the data collection was carried out with primary education students from a 2nd-year class at a rural public school in the metropolitan region of Porto Alegre. In nine sessions, they used two apps in the school's tablets: Google Classroom and Google Hangouts. Supported by Jean Piaget's theory of equilibration, the study starts with an initial theoretical proposition based on a view that the use of the apps will potentialize the cognitive imbalances due to the communication context and, therefore, the construction of the written language. The study adopted the analytical generalization as the methodological framework. The first unit of analysis presents a panorama of the data regarding the process of construction of the written language of seven subjects and on the imbalances that have occurred throughout the sessions. The second unit analyzes how the imbalances occur during the use of the apps and what are the reactions of the subjects to the disturbances. The last unit discusses the triggering situations and the circumstances of the imbalances emergence. At the end of the analyses triangulation, the theoretical proposition is revised, deepening the understanding of the imbalances role and emerging conditions for the process of construction of written language. The study concludes that situations of virtual communication, whether to an audience or to an interlocutor, create a fertile context for the occurrence of imbalances, favoring the emergence of the cognitive and/or affective necessity to understand how to write. Although, the studied apps, per se, do not create the resistances or feedbacks necessary to the process. The results point towards new paths for the development of literacy apps.

Submitted by Marlene Santos (marlene.bc.ufg@gmail.com) on 2016-08-09T19:14:53Z No. of bitstreams: 2 Dissertação - Mariana Cristina de Morais Rodrigues - 2016.pdf: 1662967 bytes, checksum: 21eacb29fa5e6184be947945ff9816a4 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-08-10T11:28:58Z (GMT) No. of bitstreams: 2 Dissertação - Mariana Cristina de Morais Rodrigues - 2016.pdf: 1662967 bytes, checksum: 21eacb29fa5e6184be947945ff9816a4 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Made available in DSpace on 2016-08-10T11:28:58Z (GMT). No. of bitstreams: 2 Dissertação - Mariana Cristina de Morais Rodrigues - 2016.pdf: 1662967 bytes, checksum: 21eacb29fa5e6184be947945ff9816a4 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2016-03-21 / Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq / Brosimum gaudichaudii Trécul. from the Moraceae family is traditionally used as a therapeutic resource to treat leukoderma. The roots are the plant’s part that contain the highest concentration of photosensitizing substances, important against leukoderma, among them psoralen and bergapten that belong to the secondary metabolite class named linear furanocoumarins. By definition, phytotherapic is the product obtained exclusively from active vegetal raw material with prophylactic, curative or palliative purpose. They characteristically do not include isolated or highly purified substances in their composition from any source, or are associated with other extracts. One of the main challenges in producing phytotherapic medicine is the complex composition of the medicinal plant that depends on climatic and geographic factors, and cultivation, drying and storage conditions. The objective of this work was to obtain solid pharmaceutical forms containing extract standardized in psoralen and bergapten of B. gaudichaudii, as well as the analyses of these pharmaceutical forms following all the parameters stated by the Normative instruction no 04 of 2014. Chapter 1 is about the vegetal drug characterization and posterior production and standardization of the liquid extract, the analytical method was co-validated by High Efficiency Liquid Chromatography (CLAE) to determine the markers levels in the liquid extract, according to ANVISA norms. The method presented to be selective, linear, precise and exact. The liquid extract was standardized in total furanocoumarins expressed in psoralen and bergapten, and the level was 0.20% (m/v) (20.81 μg/mL of psoralen and bergapten). Chapter 2 describes the development of coated pellets containing the liquid standardized extract, having an average diameter of 0.75±0.08 mm and sphericity of 0.98±0.09. The acquired pellets were encapsulated in hard gelatinous capsules (500 mg of pellets per capsule), the average level of total furanocoumarins per capsule was 641.41 μg. Tablets containing the coated pellets were produced, and it was possible to keep the pellets whole, even after the compression force of 0.5 ton was applied on them. The tablets were tested according to the analyses recommended by the Brazilian Pharmacopeia and presented a total furanocoumarin level of 587.6 μg per tablet. The analytical methodology was co-validated for the quantification of psoralen and bergapten in the coated pellets and the tablets containing them. Chapter 3 describes the obtainment and standardization of the soft extract from B.gaudichaudii and the development of tablets containing the soft extract. The soft extract was characterized according the pharmacopeia tests, and there were 82.02% (m/m) of dry residue, and the total furanocoumarin levels expressed in psoralen and bergapten was 2.93% (m/v) (58.8 μg/g of psoralen and bergapten). Three different formulations of tablets containing soft standardized extract were acquired by humid rout previous granulation. In each formulation the diluents, microcrystalline cellulose (MCC) and starch proportion were variated. The compression was done in a hydraulic press and the process was controlled to establish the compression conditions. The analytical methodology was co-validated to quantify the total furanocoumarins in the tablets and the level were 16,800 μg per tablet. / Brosimum gaudichaudii Trécul. pertencente a família Moraceae é tradicionalmente utilizada como recurso terapêutico para o tratamento de leucodermias .A raiz desta planta é a parte que contém maior concentração de substâncias fotossensibilizantes importantes contra leucodermias, dentre elas o psoraleno e o bergapteno que pertencem à classe de metabólitos secundários denominados furanocumarinas lineares. Por definição, fitoterápico é o produto obtido exclusivamente de matéria prima ativa vegetal com propósito profilático, curativo ou paliativo. Caracterizam-se por não incluir na sua composição substâncias ativas isoladas ou altamente purificadas, de qualquer origem, nem as associações dessas com outros extratos. Um dos principais desafios na produção de um medicamento fitoterápico é a complexidade da composição da planta medicinal, que depende de fatores climátios, geográficos, condições de cultivo, secagem e armazenamento. O presente trabalho teve como objetivo a obtenção de formas farmacêuticas sólidas contendo o extrato padronizado em psoraleno e bergapteno de B. gaudichaudiii, bem como a análise destas formas farmacêuticas seguindo todos os parâmetros exigidos pela Instrução normativa n° 04 de 2014. O capítulo 1 trata da caracterização da droga vegetal e posteriormente a obtenção e padronização do extrato líquido, covalidou-se o método analítico por Cromatografia a Líquido de Alta Eficiência (CLAE) para determinação dos teores dos marcadores no extrato líquido, segundo as normas da ANVISA. O método mostrou-se seletivo, linear, preciso e exato. O extrato líquido foi padronizado em furanocumarinas totais expressas em psoraleno e bergapteno, e obteve-se o teor de 0,20% (m/v) (20,81 μg/mL de psoraleno e bergapteno). O capítulo 2 descreve o desenvolvimento de pellets revestidos contendo o extrato líquido padronizado obtido, tendo um diâmetro médio 0,75+0,08 mm e esfericidade 0,98+0,09. Encapsulou-se os pellets obtidos em cápsulas gelatinosas duras (500mg de pellets por cápsula), o teor médio de furanocumarinas totais por cápsula foi 641,41μg. Obteve-se comprimidos contendo pellets revestidos e foi possível manter os pellets íntegros mesmo após aplicada à força de compressão de 0,5 ton nos mesmos. Os comprimidos foram analisados segundo os testes preconizados pela Farmacopeia Brasileira e apresentaram um teor de furanocumarinas totais de 587,6μg por comprimido. A metodologia analítica foi covalidada para quantificação do psoraleno e bergapteno tanto nos pellets revestidos como nos comprimidos contendo pellets. O capítulo 3 descreve a obtenção e padronização do extrato mole de B.gaudichaudii e o desenvolvimento de comprimidos contendo o extrato mole obtido. O extrato mole foi caracterizado segundo os testes farmacopeicos e obteve 82,02% (m/m) de teor de sólidos, e o teor de furanocumarinas totais expressas em psoraleno e bergapteno que foi 2,93% (m/v) (58,8 μg/g de psoraleno e bergapteno). Obtiveram-se três diferentes formulações de comprimidos por previa granulação por via úmida, contendo o extrato mole padronizado. Em cada formulação variou-se a proporção dos diluentes celulose microcristalina (MCC) e amido. A compressão foi feita por meio de uma prensa hidráulica e efetuou-se o controle do processo para o estabelecimento das condições de compressão. A metodologia analítica foi covalidada para quantificação de furanocumarinas totais nos comprimidos obtidos, e a concentração de furanocumarinas totais para cada comprimido foi 16800 μg por comprimido.

A doença de Chagas afeta aproximadamente 8 a 10 milhões de pessoas em todo o mundo sendo o benznidazol, o único fármaco disponível para o tratamento. Por outro lado, as ciclodextrinas têm se mostrado como grande aliada para melhorar a solubilidade de fármacos pouco solúveis, tendo sido utilizadas, inclusive, para o benznidazol. Entretanto, o comportamento químico dos complexos benznidazol-βCD e a aplicação ou formulação de um produto final com referido composto não foi ainda estudada e o objetivo do presente trabalho foi investigar a estabilidade química do fármaco e de seus complexos com betaciclodextrinas através de estudos de degradação forçada e propor uma formulação multiparticulada (minicomprimidos) com um perfil de dissolução adequado e de fácil produção para o benznidazol. Estudos de degradação do benznidazol em solução e no estado sólido foram conduzidos em meio ácido (HCl 0,1 M), alcalino (NaOH 0,1 M), em pH neutro (água), na presença de peróxido e sob ação da luz. O benznidazol na forma não complexada mostrou-se instável em meio alcalino, na presença de peróxido e sob a ação da luz, quando em solução. Porém, os complexos benznidazol-βciclodextrina e benznidazol-βciclodextrina-copovidona, não foram capazes de proteger o fármaco nas condições de estresse estudadas. Adicionalmente, foram produzidas oito formulações de benznidazol utilizando um planejamento fatorial completo com três fatores, sendo o ganho de peso, a adição da βciclodextrina e da crospovidona, em dois níveis cada (fatorial 23). O fármaco, a ciclodextrina e o desintegrante foram aplicados diretamente na superfície dos minicomprimidos inertes com auxílio da hidroxipropilmetilcelulose utilizando a tecnologia de leito fluidizado, obtendo-se formulações com mais de 80% de dissolução do fármaco em 30 minutos. A avaliação estatística dos resultados proporcionou o entendimento da influência do ganho de peso, da adição da βciclodextrina e crospovidona na dissolução do benznidazol. / Chagas disease (a.k.a. American trypanosomiasis) affects approximately 8 to 10 million people worldwide. Currently, benznidazole is the only drug available for treatment. Cyclodextrins have proven to be a valuable resource for improving the solubility of poorly-soluble drugs, and they have also been used with benznidazole. However, the chemical behavior of benznidazole-βCD complexes and the application or formulation of a final product with the aforementioned compound has still not been studied, and so the purpose of this study was to investigate the chemical stability of the drug and its complexes with β-cyclodextrins through forced degradation studies, and to propose a multi-particulate formulation with a satisfactory dissolution profile in the form of mini-tablets that are easy to produce for benznidazole. Degradation studies of benznidazole in solution and solid form were conducted using a variety of media, including acidic (HCl 0.1 M), alkaline (NaOH 0.1 M), pH-neutral (water), as well as in the presence of peroxide and under the action of light. Benznidazole, in solution form and in its uncomplexed state, proved to be unstable in the alkaline medium, in the presence of peroxide and under the action of light. Furthermore, the benznidazole-βcyclodextrin and benznidazole-βcyclodextrin-crospovidone complexes were not capable of protecting the drug under the stress conditions studied. Eight formulations of benznidazole were produced using a complete factorial design involving three factors, which were weight gain, the addition of the βcyclodextrin and the addition of crospovidone, on two levels each (23 design). The drug, the cyclodextrin and the excipient were applied directly to the surface of the inert minitablets with the aid of hydroxypropylmethyl cellulose, using fluid bed technology. Formulations with more than 80% of drug dissolution in 30 minutes were obtained. Statistical evaluation of the results provided understanding of the influence of weight gain, the addition of βcyclodextrin and crospovidone on the benznidazole dissolution

A hipertensão arterial é a principal causa da incidência de doenças cardiovasculares no mundo. Os diuréticos anti-hipertensivos como a indapamida são muito utilizados para o tratamento da hipertensão arterial, sendo a formulação de liberação prolongada muito eficaz e bem tolerada para o uso em pacientes idosos. Sistemas multiparticulados de formas farmacêuticas sólidas orais de liberação prolongada apresentam uma série de vantagens tecnológicas e biofarmacotécnicas em relação aos sistemas monolíticos.Assim, o presente trabalho teve como objetivo desenvolver formas farmacêutica sólidas multiparticuladas de indapamida com controle de liberação através de sistema de revestimento utilizando polivinilacetato e sistema matricial de hipromelose. Para avaliação das diferentes formulações de minicomprimidos de indapamida de liberação prolongada, foram empregados os aparatos 1 (cesta) e 3 (Bio-Dis) para, deste modo, identificar aquelas cuja liberação do fármaco estivesse mais próxima do produto referência (Natrilix SR® 1,5mg). Ao final, foi realizada uma busca de patentes relacionadas ao sistema multiparticulado de liberação prolongada de indapamida, para avaliar a possibilidade de uma patente para a formulação proposta. / Hypertension is the main cause of cardiovascular disease around the world. Diuretic antihypertensives, such as indapamide, are widely used for treating hypertension, and, with regards to elderly patients, its extended release formulation is the most effective and well tolerated. Multiparticulate systems of solid oral dosage forms for extended release present a series of technological and biopharmaceutical benefits, when compared to monolithic systems. Thus, the purpose of this study was to develop a multiparticulate solid form of indapamide with controlled release by using a polyvinyl acetate coating system and a hypromelose matrix. For an evaluation of different formulations of indapamide extended release mini-tablets, a 1 (basket) and 3 (Bio-Dis) apparatus was used to identify those with a drug release rate closest to the reference product, Natrilix® SR 1.5mg. Finally, multiparticulate indapamide extended release patents were researched, in order to evaluate the possibility of obtaining a patent for the proposed formulation.

Fármacos pouco solúveis em água são um dos maiores desafios encontrados em formulação de comprimidos, uma vez que, se não adequadamente formulados, podem apresentar problemas de dissolução e de biodisponibilidade. O presente trabalho teve como objetivo produzir comprimidos de glibenclamida 5 mg (hipoglicemiante oral pouco solúvel) utilizando diferentes processos visando a melhoria da dissolução do fármaco e comparar a liberação in vitro (perfil de dissolução) das formulações entre si, bem como em relação ao medicamento referência no Brasil, Daonil®. Foram obtidas 19 formulações por compressão direta empregando dispersão sólida, complexação com ciclodextrina ou micronização do fármaco. Os comprimidos foram analisados quanto ao aspecto, peso médio, dureza, friabilidade, teor e eficiência de dissolução. Os resultados indicaram que, dentre os processos estudados, a utilização de complexos glibenclamida-β-ciclodextrina e glibenclamida micronizada, promoveram uma melhora da dissolução do fármaco. O superdesintegrante Explocel® promoveu significativa melhoria no perfil de dissolução em todas as formulações em que estava presente. A utilização do complexo glibenclamida-β-ciclodextrina com o Explocel® apresentou perfil de dissolução estatisticamente semelhante ao Daonil®, além de atender aos demais requisitos físico-químicos. / Slightly soluble drugs are one of the largest challenges found in tablet formulation, once, if not appropriately formulated, they can present dissolution and bioavailability problems. The present work had as objective to produce 5 mg glibenclamide (practically insoluble hipoglicemic drug) tablets using different processes which aim at enhancing drug dissolution and to compare the in vitro release (dissolution profile) of these formulations with each other as well as with the reference medicine in Brazil, Daonil®. 19 diferent formulations were obtained through direct compression using solid dispersion, cyclodextrin complexion or micronization of the drug. The tablets were also analyzed in relation to aspect, medium weight, hardness, friability, assay and dissolution eficiency. The results indicated that, among the studied processes, an enhancement of the dissolution rate of the drug have arisen from the use of the glibenclamide-β-cyclodextrin complex and the micronized glibenclamide. The disintegrant Explocel® promoted enhancement in the dissolution rate in all the formulations in which it was present. The use of the glibenclamide-β-cyclodextrin complex with Explocel® have presented the best dissolution profile, statistically similar to Daonil®, besides accomplishing the other physico-chemical requirements.

Οι ασύρματες κινητές υπολογιστικές συσκευές (tablets) και οι εφαρμογές τους αποτελούν μια σημαντική πρόκληση για τα εκπαιδευτικά συστήματα, αφού διαφοροποιούν και επεκτείνουν τις χρήσεις των τεχνολογιών για μετάδοση και αναζήτηση πληροφοριών και για ανθρώπινη επικοινωνία και συνεργασία. Οι συσκευές αυτές είναι μεταφέρσιμες και λειτουργικές παντού, ενώ ταυτόχρονα μπορούν να συνδεθούν σε κινητά ή ασύρματα δίκτυα με σκοπό την ανταλλαγή οποιασδήποτε φύσης δεδομένων. Οι δυνατότητές τους αυτές, η φορητότητα και η συνδεσιμότητα, καθιστούν τις συσκευές αυτές εργαλεία που εν δυνάμει μπορούν να επηρεάσουν σημαντικά την εκπαίδευση και συνακόλουθα τη μάθηση. Σκοπός της συγκεκριμένης έρευνας είναι η ανάλυση της χρήσης των κινητών υπολογιστικών συσκευών στη σχολική τάξη και η μελέτη των δυνατών μαθησιακών χρήσεων των κινητών υπολογιστικών συσκευών στο δημοτικό σχολείο. Οι κινητές υπολογιστικές συσκευές, λόγω των ιδιαίτερων χαρακτηριστικών τους, είναι δυνατό να αποτελέσουν εργαλείο διδασκαλίας και μάθησης σε όλα τα γνωστικά αντικείμενα του προγράμματος σπουδών. Πιο συγκεκριμένα, στόχοι της παρούσας έρευνας είναι η μελέτη του τρόπου αλληλεπίδρασης και συνεργασίας μαθητών δημοτικού σχολείου με τις κινητές υπολογιστικές συσκευές, η αναζήτηση αποτελεσματικού τρόπου ενσωμάτωσης των συσκευών αυτών στη μαθησιακή διαδικασία, με τη χρήση διαφορετικής κατηγορίας εφαρμογών, με στόχο την ανάδειξη των ιδιαίτερων χαρακτηριστικών και δυνατοτήτων τους και η διερεύνηση της αποδοχή της συγκεκριμένης τεχνολογίας από τους μαθητές και τους εκπαιδευτικούς του δημοτικού σχολείου. Για το σκοπό αυτό, σχεδιάστηκε και αξιολογήθηκε ένα εκπαιδευτικό σενάριο, οι δραστηριότητες του οποίου αφορούσαν διαφορετικές μαθησιακές περιοχές του προγράμματος σπουδών του Δημοτικού Σχολείου. Αξιοποιήθηκαν οι δυνατότητες των κινητών υπολογιστικών συσκευών και αναδείχθηκαν οι δυνατότητές τους που υποστηρίζουν και πλαισιώνουν τη μαθησιακή διαδικασία. Το εκπαιδευτικό σενάριο υλοποιήθηκε στο 42ο Δημοτικό Σχολείο Πάτρας, και συγκεκριμένα στα δύο τμήματα της Τετάρτης Τάξης του σχολείου, σε συνεργασία με τον εκπαιδευτικό της τάξης στα πλαίσια μιας συμμετοχικής εθνογραφικής μελέτης περίπτωσης. Από την ανάλυση των δεδομένων της έρευνας φαίνεται πως οι κινητές υπολογιστικές συσκευές μπορούν να καταστούν ένα χρήσιμο και αποτελεσματικό εργαλείο που προάγει τη συνεργασία των παιδιών όταν αυτά δουλεύουν σε ομάδες, αρκεί να γίνει από τον εκπαιδευτικό ο κατάλληλος σχεδιασμός και η διαδικασία να υποστηρίζεται από τις κατάλληλες εφαρμογές. Ακόμη, οι εφαρμογές που φαίνεται να ενισχύουν ή να αναπτύσσουν την εποικοδομητική συνεργασία των μαθητών είναι οι εφαρμογές προσομοίωσης, χωρίς να σημαίνει πως οι άλλου τύπου εφαρμογές δεν προάγουν τη συνεργασία και την ορθολογική χρήση των συσκευών. Επιπλέον, είναι σημαντικός ο προσεκτικός σχεδιασμός μαθησιακών δραστηριοτήτων για στόχους του αναλυτικού προγράμματος σπουδών του δημοτικού σχολείου από άρτια, στην πράξη, επιμορφωμένους εκπαιδευτικούς που γνωρίζουν τις ανάγκες της τάξης και των μαθητών τους. Τέλος, μαθητές και εκπαιδευτικοί φαίνεται να είναι θετικοί στην ορθολογική ενσωμάτωση των συσκευών στην εκπαιδευτική διαδικασία. / -

Informations- och kommunikationstekniken (IKT) är en viktig del av vår vardag, då tekniken på olika sätt förenklar och effektiviserar vårt dagliga agerande på arbetet och i hemmet. Genom att interagera med tekniken kan vi kommunicera med andra människor, på en mängd olika sätt genom en mängd olika medier. Förskolan ska på ett lustfyllt och varierande sätt spegla samhällets utbredning av de digitala verktygen och lärplattan har blivit allt mer vanligt förekommande i förskoleverksamheten. Lärplattan har många egenskaper och möjligheter, exempelvis kan det möjliggöra tillfällen av språklig interaktion med olika samtalspartner, medier och genrer, vilket kan utveckla barns kommunikativa kompetenser. Syftet med denna uppsats är att undersöka förutsättningarna för och användandet av lärplattan som ett digitalt verktyg i barnets litteracitetsutveckling på förskolan. Studien baseras på en mindre enkätundersökning riktad till förskolechefer samt intervjuer med tre pedagoger som aktivt arbetar med lärplattan på förskolan. Denna metod tror jag på bästa möjliga sätt ska kunna uppfylla uppsatsens syfte. Resultatet visar att förutsättningarna på förskolorna är relativt lika. Förskolechefernas erfarenhet av lärplattor och deras synsätt till användandet av lärplattor i verksamheten är mestadels positivt. Samtliga förskolor som informanterna representerar har tillgång till lärplattor, i olika utsträckning. Det som skiljer förskolorna åt är hur den praktiska implementeringen genomförts. Resultatet visar även att praktiken är relativt lika varandra. De intervjuade pedagogerna talar om ett medvetet användande, en närvarande pedagog och ett meningsfullt lärandesammanhang. De olika situationerna där barnen använder lärplattan, har litteracitet som en gemensam nämnare. Pedagogerna använder inte begreppet litteracitet, men de beskriver situationer för språkande och kommunikation, ur ett sociokulturellt perspektiv. / Information and communication technology (ICT) is an essential part of our everyday life, as the technology in different ways simplifies and streamlines our daily behavior at work and at home. By interacting with the technology we are able to communicate with other people, in a variety of ways through a variety of media. Preschools should in an enjoyable and varied way reflect the propagation of digital tools in society and the learning tablet has become increasingly common in early childhood education. This tool has many features and capabilities, for example, it may allow for occasions of linguistic interaction with various interlocutors, media and genres, which can develop children's communication skills. The purpose of this paper is to examine the conditions for and use of the learning tablet as a digital tool in the child's development of literacy, in preschool. The study is based on a smaller survey of preschool managers and interviews with three teachers who are actively working with the learning tablet in preschool. I believe that this method is the best way to fulfill the thesis purpose. The result shows that the conditions in the preschools are relatively similar. Preschool managers' experience of learning tablets and there approach to the use of learning tablets in preschool, is mostly positive. Every preschool which the informants are representing have access to learning tablets, in different extents. What distinguishes the preschools apart is how the practical implementation is carried out. The results also show that the effect is relatively similar. The interviewed teachers talk about a conscious use, a present educator and a meaningful learning context. The different situations, in which children use the learning tablet, have literacy as a common denominator. The teachers don’t use the concept of literacy, but they describe situations for language and communication, from a sociocultural perspective.

Malaria is a parasitic disease claiming one million lives worldwide annually. Unfortunately, malaria-endemic countries in need of good quality medicines are also overwhelmed with counterfeit or substandard medicine. This results in treatment inefficacy, resistance towards treatment and death. Counterfeit or substandard quinine sulfate tablets are known to have infiltrated the market, however at this point in time, treatment efficacy of quinine sulfate has fortunately not yet been significantly impaired by resistance, but immediate action is required to prevent it from becoming obsolete. Validated analytical methods with justified specifications are effective in controlling the quality of medicines and to minimise the effect of poor quality medicines. Pharmacopoeia specifies analytical quality control procedures and accompanying specifications to standardise acceptable levels of product quality. Understandably, different monographs of different pharmacopoeias are developed by different independent laboratories and therefore their respective test procedures/specifications for the same FPP may differ from each other. Institutions such as the Pharmacopoeial Dicussion Group (PDG) aim to harmonise pharmacopoeia in order to synchronise final outcomes. This study evaluated the relevancy of differences in analytical procedures, results and specifications for quinine sulfate tablets set by the United States Pharmacopoeia (USP), British Pharmacopoeia (BP) and International Pharmacopoeia (Ph.Int.) in an aim to ensure that these different methods all provide with similar final outcomes and that they be effective in successfully evaluating the quality of quinine sulfate tablets. Four quinine sulfate tablet products were obtained from different manufacturers and were subjected to the tests of all three pharmacopoeia – BP, USP and Ph.Int. The results from identification, assay and related substance testing concluded that the outcomes were the same between the pharmacopoeia despite their differences in techniques/procedures/specifications. The assay, identification and related substances methods and specifications set by each respective monograph were deemed appropriate to evaluate the quality of quinine sulfate tablets. Even with differences in methodology, quantitative techniques and specifications, the USP and BP dissolution methods for quinine sulfate tablets shared the same final outcome at the first stage of dissolution, whereas none of the products achieved a compliant outcome using the Ph.Int. dissolution method. Possible reasons for the poor dissolution (when using the Ph.Int. method) were identified and investigated. Investigation into the solubility of quinine sulfate found the Ph.Int. dissolution method conditions to be too stringent, as the solubility of quinine sulfate in phosphate buffer pH 6.8 (dissolution medium specified by the Ph.Int.) was found to be much less than in acidic media (as proposed by the BP and USP dissolution methods). Several adapted dissolution methods (called developmental studies) were investigated to serve as potential alternatives for the Ph.Int. dissolution method. The developmental studies investigated an alternative dissolution medium, agitation rates (50 rpm, 75 rpm, 100 rpm) and medium volumes (500 ml, 750 ml, 900 ml and 1000 ml). Developmental study 6 was proposed as an alternative dissolution method. Developmental study 6 stipulates the use of the same medium as the original Ph.Int. method, as it was deemed the medium of choice for its discriminatory ability. To address the impaired solubility of quinine sulfate in phosphate buffer, the medium volume and agitation were increased (in reference to the original method) to 900 ml and 100 rpm respectively. The same analytical quantitation technique (UV-Vis spectroscopy) is proposed for Developmental study 6. The newly proposed method provided with final outcomes comparable to that of the USP and BP, however having more discriminatory power than the USP and BP. / MSc (Pharmaceutics), North-West University, Potchefstroom Campus, 2014

Malaria is a parasitic disease claiming one million lives worldwide annually. Unfortunately, malaria-endemic countries in need of good quality medicines are also overwhelmed with counterfeit or substandard medicine. This results in treatment inefficacy, resistance towards treatment and death. Counterfeit or substandard quinine sulfate tablets are known to have infiltrated the market, however at this point in time, treatment efficacy of quinine sulfate has fortunately not yet been significantly impaired by resistance, but immediate action is required to prevent it from becoming obsolete. Validated analytical methods with justified specifications are effective in controlling the quality of medicines and to minimise the effect of poor quality medicines. Pharmacopoeia specifies analytical quality control procedures and accompanying specifications to standardise acceptable levels of product quality. Understandably, different monographs of different pharmacopoeias are developed by different independent laboratories and therefore their respective test procedures/specifications for the same FPP may differ from each other. Institutions such as the Pharmacopoeial Dicussion Group (PDG) aim to harmonise pharmacopoeia in order to synchronise final outcomes. This study evaluated the relevancy of differences in analytical procedures, results and specifications for quinine sulfate tablets set by the United States Pharmacopoeia (USP), British Pharmacopoeia (BP) and International Pharmacopoeia (Ph.Int.) in an aim to ensure that these different methods all provide with similar final outcomes and that they be effective in successfully evaluating the quality of quinine sulfate tablets. Four quinine sulfate tablet products were obtained from different manufacturers and were subjected to the tests of all three pharmacopoeia – BP, USP and Ph.Int. The results from identification, assay and related substance testing concluded that the outcomes were the same between the pharmacopoeia despite their differences in techniques/procedures/specifications. The assay, identification and related substances methods and specifications set by each respective monograph were deemed appropriate to evaluate the quality of quinine sulfate tablets. Even with differences in methodology, quantitative techniques and specifications, the USP and BP dissolution methods for quinine sulfate tablets shared the same final outcome at the first stage of dissolution, whereas none of the products achieved a compliant outcome using the Ph.Int. dissolution method. Possible reasons for the poor dissolution (when using the Ph.Int. method) were identified and investigated. Investigation into the solubility of quinine sulfate found the Ph.Int. dissolution method conditions to be too stringent, as the solubility of quinine sulfate in phosphate buffer pH 6.8 (dissolution medium specified by the Ph.Int.) was found to be much less than in acidic media (as proposed by the BP and USP dissolution methods). Several adapted dissolution methods (called developmental studies) were investigated to serve as potential alternatives for the Ph.Int. dissolution method. The developmental studies investigated an alternative dissolution medium, agitation rates (50 rpm, 75 rpm, 100 rpm) and medium volumes (500 ml, 750 ml, 900 ml and 1000 ml). Developmental study 6 was proposed as an alternative dissolution method. Developmental study 6 stipulates the use of the same medium as the original Ph.Int. method, as it was deemed the medium of choice for its discriminatory ability. To address the impaired solubility of quinine sulfate in phosphate buffer, the medium volume and agitation were increased (in reference to the original method) to 900 ml and 100 rpm respectively. The same analytical quantitation technique (UV-Vis spectroscopy) is proposed for Developmental study 6. The newly proposed method provided with final outcomes comparable to that of the USP and BP, however having more discriminatory power than the USP and BP. / MSc (Pharmaceutics), North-West University, Potchefstroom Campus, 2014

Sistemas monolíticos particulados contendo os constituintes ativos veiculados na forma de grânulos revestidos - pellets - têm recebido crescente atenção nos últimos anos, em função da otimização na biodisponibilidade e segurança na liberação do fármaco. A utilização destas unidades, como componentes de comprimidos traz, como principal vantagem, a divisibilidade da forma sem a perda do perfil biofarmacêutico desejado para o fármaco. Para sua produção, é indispensável a manutenção da integridade do revestimento daquelas unidades. Uma estratégia para o alcance deste objetivo envolve a utilização de grânulos inertes deformantes, comprimidos em conjunto com os grânulos revestidos, que atuam como um sistema de amortecimento das forças de compressão. Neste trabalho investigou-se a produção de grânulos deformantes através de dois métodos de granulação por via úmida, avaliando a influência de adjuvantes sobre as características dos produtos obtidos. Empregando a técnica de extrusão/esferonização obtiveram-se grânulos com propriedades de fluxo, empacotamento e resistência mecânica aceitáveis. O efeito dos adjuvantes sobre as etapas tecnológicas foi estudado por meio de um planejamento fatorial. Testaram-se duas variedades de celulose microcristalina, os desintegrantes croscarmelose sódica e crospovidona e soluções aglutinantes aquosas e hidroetanólicas de povidona. Para o desenvolvimento dos comprimidos utilizaram-se, como modelo, grânulos revestidos gastro-resistentes contendo omeprazol. A influência da composição dos grânulos deformantes sobre a liodisponibilidade do fármaco dos comprimidos foi avaliada através de análise fatorial 23. Os grânulos deformantes protegeram o revestimento polimérico dos pellets com diferentes intensidades. / Monolythic particulate systems containing the active constituents as coated pellets became great interest due to the improvement of safety and bioavailability. The use of such units as components of tablets shows as main advantages the divisibility of the pharmaceutical dosage form without loosing the desired biopharmaceutical profile of the drug. Consequently for the tablet production, the integrity of the polymeric film must be attained. A strategic option involves the utilization of inert soft pellets, which could be compressed together with the film coated pellets, absorbing the compaction forces. In this work the production of soft pellets was investigated using two wet granulation methods and evaluating the influence of formulation adjuvants on the pellets properties. The extrusion/spheronization technique yielded pellets with acceptable flow, packing and mechanical characteristics. The influence of the adjuvants on the technological steps was carried out through a statistical designed experiment. Microcrystalline cellulose from two producers, the disintegrants sodium croscarmellose and crospovidone, and aqueous and hydroethanolic dispersions of povidone, as binder, were tested. For the tablets development omeprazol gastroresistant film coated pellets were used as model. Aiming at the study of the influence of the soft pellets composition on drug lyoavailability was performed a 23 factorial experiment. The soft pellets protected at different intensities the polymeric coating of the gastroresistant pellets.