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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
301

Systém hodnocení a odměňování pracovníků ve vybrané organizaci / Systém hodnocení a odměňování pracovníků ve vybrané organizaci

REMTOVÁ, Jitka January 2017 (has links)
The goal of this diploma thesis entitled "The evaluation and rewarding systemof employees in a specific organization" was to analyze the evaluation a rewarding system of personal bankers in Moneta Money bank a.s. Based on these analyses, to propose changes, that would contribute to improving the quality and effectiveness of this area. This thesis has two parts. The first part contains a summary of theoretical information relevant to this issue. The practical part contains description of the organization Moneta Money Banks Inc., a description of the evaluation and rewarding system of personal bankers in this organization and an analysis of these systems. The analysis used survey. The survey showed that personal bankers don't have the means or opportunity to evaluate their superior. And personal bankers are missing personal approach by Moneta Money bank a.s. This diploma thesis proposes implementation of these "personal bonuses" into the rewarding system: gifts or bonuses for years of service, for instance at the occasion of eymployee's jubilee. The next proposed change was the introduction of 360-degree feedback.
302

Participação do cálcio citosólico sobre a ação espasmolítica do ácido ent-7a-acetoxitraquiloban-18-óico e de seu derivado hidroxilado em íleo isolado de cobaia / Partipation of cytosolic calcium in spasmolytic action of ent-7a-acetoxytrachyloban-18-oic acid and its hidroxylated derivated on guinea-pig ileum

Santos, Rosimeire Ferreira dos 30 March 2010 (has links)
Made available in DSpace on 2015-05-08T15:00:02Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 1953357 bytes, checksum: 23121995cc00993662a60006ebf50ffe (MD5) Previous issue date: 2010-03-30 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES / From the stem bark of Xylopia langsdorfiana A. St.-Hil. & Tul. (Annonaceae), popularly known as pimenteria da terra , was isolated the diterpene ent-7-α-acetoxytrachyloban-18-oic acid (trachylobane-360) from which it was made a structural modification in which the acetoxy group was substituted by hydroxy generating the ent-7a-hidroxitrachyloban-18-oic acid (trachylobane-318). How there are some reports that show spasmolytic activity of some diterpenes, we aimed to investigate this activity on male rat aorta, rat uterus, guinea-pig trachea and ileum. On rat aorta and rat uterus nor trachylobane-360 or its derivative trachylobane-318 promoted significant spasmolytic effect until the concentration of 10-4 M. However on guinea-pig trachea, only the derivative relaxed this organ pre-contracted with carbachol (CCh) in the presence (EC50 = 3.3 0.9 ± 0.4 x 10-5 M) and absence (EC50 = 3.5 ± x 10-5 M) of functional epithelium, in a equipotent manner, suggesting a possible direct effect on tracheal smooth muscle and that the structural modification was essential for the relaxant effect in this organ. On the other hand, on guinea pig ileum, both diterpenes inhibited the phasic contractions induced by CCh or histamine. When the ileum was pre-contracted with KCl, CCh or histamine, the diterpenes induced relaxation and this effect is not by competitive antagonism of histamine, which was confirmed by the shifted of the cumulative curves to histamine to the right, in a non-parallel manner with reduction of the maximal effect (Emax). How the tonic component of contraction induced by KCl, CCh or histamine is maintained mainly by the opening of CaV, we hypothesized that the trachylobanes could be acting on these channels. The hypothesis was confirmed with the observation that both diterpenes antagonized the CaCl2-induced contractions in depolarizing Ca2+-free solution also relaxed the ileum pre-contracted by S-(-) Bay K 8644, an Cav1 agonist (EC50 = 3.5 ± 0.7 x 10-5 e 5.5 ± 0.3 x 10-5 M, respectively) confirming that the Cav subtype involved is the L-type (Cav1.2). To investigate the involvement of K+ channels to the effect of diterpenes as observed that the relaxation curves of trachylobane-360 (EC50 = 0.5 ± 0.04 x 10-4 M) and trachylobane-318 (EC50 = 2.0 ± 0.5 x 10-5 M) were significantly shifted to the right in the presence of 5 mM TEA+, a non-selective channel blocker for K+, suggesting involvement of these channels in the effects of diterpenes. The effect of trachylobane-360 appears to involve the subtypes of K+ channels (KATP, SKCa, Kv and BKCa,) since the CE50 have not changed in the presence of blockers of these channels. Interestingly the effect of trachylobane-318 appears to involve the activation of the channel type KATP, Kv and SKCa but not BKCa, evidenced by shifts from the relaxation curves to the right in the presence of K+ channels blockers as glibenclamide, apamin and 4-AP, respectively. These results all together suggest that the structural change was essential for these differentiated effects, but not for the involvement of the cyclic nucleotides pathway, since that in the presence of aminophylline the relaxation curves of trachylobanes were not modified. Both diterpenes reduce the intensity of fluorescence on intestinal myocytes of guinea-pig ileum stimulated by histamine which reflect reduction of [Ca2+]c, what would explain the spasmolytic effects of these diterpenes in functional level. / Das cascas do caule da Xylopia langsdorfiana A. St.-Hil. & Tul. (Annonaceae), conhecida popularmente como pimenteira da terra foi isolado o diterpeno ácido ent-7a-acetoxitraquiloban-18-óico (traquilobano-360) que sofreu uma modificação estrutural do grupo acetoxi pelo hidroxi gerando o ácido ent-7a-hidroxitraquiloban-18-óico (traquilobano-318). O objetivo deste trabalho foi realizar um estudo comparativo de uma possível atividade espasmolítica dos diterpenos em aorta de rato, útero de rata, traquéia e íleo de cobaia. Foram realizadas medidas de contrações isotônicas e isométricas e do cálcio citosólico. Em aorta de rato e útero de rata nenhum dos diterpenos promoveu efeito espasmolítico significante até a concentração de 10-4 M. Já em traquéia de cobaia, apenas o traquilobano-318 relaxou este órgão pré-contraído com carbacol (CCh) na presença e na ausência de epitélio funcional, de maneira equipotente, sugerindo um possível efeito direto no músculo liso traqueal e que a modificação estrutural foi essencial para o efeito relaxante neste órgão. Por outro lado, em íleo de cobaia, ambos os diterpenos inibiram as contrações fásicas induzidas por CCh ou por histamina. No íleo pré-contraído com KCl, CCh ou histamina os diterpenos induziram relaxamento e este efeito não se dá por antagonismo competitivo dos receptores histaminérgicos, o que foi confirmado pelo desvio das curvas cumulativas induzidas pela histamina para a direita com redução dos Emax. Como o componente tônico da contração induzida por KCl, CCh ou histamina é mantido principalmente pela abertura dos CaV, hipotetizou-se que os traquilobanos poderiam estar agindo sobre estes canais. Hipótese confirmada com a observação de que ambos diterpenos antagonizaram as contrações induzidas por CaCl2 em meio despolarizante sem Ca2+ além de relaxarem o íleo pré-contraído por S-(-) Bay K 8644, agonista dos Cav1 (CE50 = 3,5 ± 0,7 x 10-5 e 5,5 ± 0,3 x 10-5 M, respectivamente) confirmando assim que o subtipo de Cav envolvido é o Cav1.2. Para investigar a participação dos canais para K+ no efeito dos diterpenos, observou-se que as curvas de relaxamento do traquilobano-360 (CE50 = 0,5 ± 0,04 x 10 -4 M) e do traquilobano-318 (CE50 = 2,0 ± 0,5 x 10-5 M) foram significantemente desviadas para a direita na presença de 5 mM de TEA+, bloqueador não seletivo dos canais para K+, sugerindo a participação destes canais no efeito dos diterpenos. O efeito do traquilobano-360 parece não envolver os subtipos de canais para K+ (KATP, SKCa, Kv e BKCa,) uma vez que o relaxamento não foi alterado na presença dos bloqueadores destes canais. Entretanto, o efeito do traquilobano-318 parece envolver a ativação dos canais do tipo KATP, SKCa e Kv mas não dos BKCa, fato este evidenciado pelos desvios da curva de relaxamento para direita na presença dos bloqueadores de canais para K+ como glibenclamida, apamina e 4-AP, respectivamente. Estes resultados sugerem que a modificação estrutural foi essencial para esses efeitos diferenciados, mas não para o envolvimento da via dos nucleotídios cíclicos, uma vez que na presença da aminofilina as curvas de relaxamento dos traquilobanos não foram alteradas. Os dois diterpenos reduziram a intensidade de fluorescência em miócitos intestinais de íleo de cobaia estimulados por histamina em conseqüência da redução da [Ca2+]c, o que explica os efeitos espasmolíticos destes diterpenos em nível funcional.
303

Participação Do Cálcio Citosólico Sobre A Ação Espasmolítica Do Ácido Ent-7a-Acetoxitraquiloban-18-Óico E De Seu Derivado Hidroxilado Em Íleo Isolado De Cobaia / Partipation of cytosolic calcium in spasmolytic action of ent-7a-acetoxytrachyloban-18-oic acid and its hidroxylated derivated on guinea-pig ileum

Santos, Rosimeire Ferreira dos 30 March 2010 (has links)
Made available in DSpace on 2015-05-14T13:00:12Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 1953353 bytes, checksum: 1474e81c59d80eee12bba062027ce9d3 (MD5) Previous issue date: 2010-03-30 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES / From the stem bark of Xylopia langsdorfiana A. St.-Hil. & Tul. (Annonaceae), popularly known as pimenteria da terra , was isolated the diterpene ent-7-α-acetoxytrachyloban-18-oic acid (trachylobane-360) from which it was made a structural modification in which the acetoxy group was substituted by hydroxy generating the ent-7a-hidroxitrachyloban-18-oic acid (trachylobane-318). How there are some reports that show spasmolytic activity of some diterpenes, we aimed to investigate this activity on male rat aorta, rat uterus, guinea-pig trachea and ileum. On rat aorta and rat uterus nor trachylobane-360 or its derivative trachylobane-318 promoted significant spasmolytic effect until the concentration of 10-4 M. However on guinea-pig trachea, only the derivative relaxed this organ pre-contracted with carbachol (CCh) in the presence (EC50 = 3.3 0.9 ± 0.4 x 10-5 M) and absence (EC50 = 3.5 x 10-5 M) of functional epithelium, in a equipotent manner, suggesting a possible direct effect on tracheal smooth muscle and that the structural modification was essential for the relaxant effect in this organ. On the other hand, on guinea pig ileum, both diterpenes inhibited the phasic contractions induced by CCh or histamine. When the ileum was pre-contracted with KCl, CCh or histamine, the diterpenes induced relaxation and this effect is not by competitive antagonism of histamine, which was confirmed by the shifted of the cumulative curves to histamine to the right, in a non-parallel manner with reduction of the maximal effect (Emax). How the tonic component of contraction induced by KCl, CCh or histamine is maintained mainly by the opening of CaV, we hypothesized that the trachylobanes could be acting on these channels. The hypothesis was confirmed with the observation that both diterpenes antagonized the CaCl2-induced contractions in depolarizing Ca2+-free solution also relaxed the ileum pre-contracted by S-(-) Bay K 8644, an Cav1 agonist (EC50 = 3.5 ± 0.7 x 10-5 e 5.5 ± 0.3 x 10-5 M, respectively) confirming that the Cav subtype involved is the L-type (Cav1.2). To investigate the involvement of K+ channels to the effect of diterpenes as observed that the relaxation curves of trachylobane-360 (EC50 = 0.5 ± 0.04 x 10-4 M) and trachylobane-318 (EC50 = 2.0 ± 0.5 x 10-5 M) were significantly shifted to the right in the presence of 5 mM TEA+, a non-selective channel blocker for K+, suggesting involvement of these channels in the effects of diterpenes. The effect of trachylobane-360 appears to involve the subtypes of K+ channels (KATP, SKCa, Kv and BKCa,) since the CE50 have not changed in the presence of blockers of these channels. Interestingly the effect of trachylobane-318 appears to involve the activation of the channel type KATP, Kv and SKCa but not BKCa, evidenced by shifts from the relaxation curves to the right in the presence of K+ channels blockers as glibenclamide, apamin and 4-AP, respectively. These results all together suggest that the structural change was essential for these differentiated effects, but not for the involvement of the cyclic nucleotides pathway, since that in the presence of aminophylline the relaxation curves of trachylobanes were not modified. Both diterpenes reduce the intensity of fluorescence on intestinal myocytes of guinea-pig ileum stimulated by histamine which reflect reduction of [Ca2+]c, what would explain the spasmolytic effects of these diterpenes in functional level. / Das cascas do caule da Xylopia langsdorfiana A. St.-Hil. & Tul. (Annonaceae), conhecida popularmente como pimenteira da terra foi isolado o diterpeno ácido ent-7-acetoxitraquiloban-18-óico (traquilobano-360) que sofreu uma modificação estrutural do grupo acetoxi pelo hidroxi gerando o ácido ent-7a-hidroxitraquiloban-18-óico (traquilobano-318). O objetivo deste trabalho foi realizar um estudo comparativo de uma possível atividade espasmolítica dos diterpenos em aorta de rato, útero de rata, traquéia e íleo de cobaia. Foram realizadas medidas de contrações isotônicas e isométricas e do cálcio citosólico. Em aorta de rato e útero de rata nenhum dos diterpenos promoveu efeito espasmolítico significante até a concentração de 10-4 M. Já em traquéia de cobaia, apenas o traquilobano-318 relaxou este órgão pré-contraído com carbacol (CCh) na presença e na ausência de epitélio funcional, de maneira equipotente, sugerindo um possível efeito direto no músculo liso traqueal e que a modificação estrutural foi essencial para o efeito relaxante neste órgão. Por outro lado, em íleo de cobaia, ambos os diterpenos inibiram as contrações fásicas induzidas por CCh ou por histamina. No íleo pré-contraído com KCl, CCh ou histamina os diterpenos induziram relaxamento e este efeito não se dá por antagonismo competitivo dos receptores histaminérgicos, o que foi confirmado pelo desvio das curvas cumulativas induzidas pela histamina para a direita com redução dos Emax. Como o componente tônico da contração induzida por KCl, CCh ou histamina é mantido principalmente pela abertura dos CaV, hipotetizou-se que os traquilobanos poderiam estar agindo sobre estes canais. Hipótese confirmada com a observação de que ambos diterpenos antagonizaram as contrações induzidas por CaCl2 em meio despolarizante sem Ca2+ além de relaxarem o íleo pré-contraído por S-(-) Bay K 8644, agonista dos Cav1 (CE50 = 3,5 ± 0,7 x 10-5 e 5,5 ± 0,3 x 10-5 M, respectivamente) confirmando assim que o subtipo de Cav envolvido é o Cav1.2. Para investigar a participação dos canais para K+ no efeito dos diterpenos, observou-se que as curvas de relaxamento do traquilobano-360 (CE50 = 0,5 ± 0,04 x 10 -4 M) e do traquilobano-318 (CE50 = 2,0 ± 0,5 x 10-5 M) foram significantemente desviadas para a direita na presença de 5 mM de TEA+, bloqueador não seletivo dos canais para K+, sugerindo a participação destes canais no efeito dos diterpenos. O efeito do traquilobano-360 parece não envolver os subtipos de canais para K+ (KATP, SKCa, Kv e BKCa,) uma vez que o relaxamento não foi alterado na presença dos bloqueadores destes canais. Entretanto, o efeito do traquilobano-318 parece envolver a ativação dos canais do tipo KATP, SKCa e Kv mas não dos BKCa, fato este evidenciado pelos desvios da curva de relaxamento para direita na presença dos bloqueadores de canais para K+ como glibenclamida, apamina e 4-AP, respectivamente. Estes resultados sugerem que a modificação estrutural foi essencial para esses efeitos diferenciados, mas não para o envolvimento da via dos nucleotídios cíclicos, uma vez que na presença da aminofilina as curvas de relaxamento dos traquilobanos não foram alteradas. Os dois diterpenos reduziram a intensidade de fluorescência em miócitos intestinais de íleo de cobaia estimulados por histamina em conseqüência da redução da [Ca2+]c, o que explica os efeitos espasmolíticos destes diterpenos em nível funcional.
304

Überlegungen zur theoretischen Konzeption männlicher Identität: Ein Forschungsüberblick mit exemplarischer Vertiefung

Horlacher, Stefan 13 March 2020 (has links)
In den letzten Jahren ist nicht nur in der Forschung, sondern auch in der breiten Öffentlichkeit die akute Problematik der männlichen Identitätsfindung beziehungsweise Identitätskonstruktion unübersehbar geworden. Medial schlug sich dies allein im Januar und Februar 2008 in entsprechenden Leitartikeln sowohl im SPIEGEL als auch in der ZEIT nieder und lebensweltlich nimmt die Anzahl der von männlichen Jugendlichen ausgehenden Gewalttaten unvermindert zu. Ein Verweis auf die durch die Medien gegangenen U-Bahn-Attacken (München) mag hier genauso genügen wie die Erinnerung an die gewalttätigen Zwischenfälle an der Columbine High School, der Virginia Tech University, der Northern Illinois University (DeKalb), der Berliner Rütli Schule, dem Erfurter Gutenberg Gymnasium oder der Jokela Schule in Tuusula, Finnland.
305

Radioaktivität und Strahlenschutz: Normalität oder Risiko?

14 September 2021 (has links)
Radioaktivität ist ein natürlicher Bestandteil unserer Lebenswelt. Dennoch erzeugt der Begriff „Radioaktivität“ bei vielen Menschen Unbehagen. Die von radioaktiven Stoffen ausgesandte Strahlung wird oft als bedrohlich empfunden, unabhängig davon, wie stark sie ist und woher sie stammt. Dabei vergessen wir oft, dass jeder Mensch auf der Erde auf natürliche Weise stets und überall radioaktiver Strahlung oder besser „ionisierender Strahlung“ ausgesetzt ist. Die natürlichen Strahlenquellen existieren unabhängig vom Menschen seit der Entstehung der Erde und verursachen die so genannte natürliche Strahlenexposition* des Menschen. Daneben hat sich der Mensch mit der Entwicklung von Industrie Forschung seit dem letzten Jahrhundert in zunehmendem Maße radioaktive Stoffe und die von ihnen ausgesandte ionisierende Strahlung nutzbar gemacht. Damit wurde den natürlichen Strahlenquellen eine Reihe künstlicher Strahlenquellen hinzugefügt, die die Ursache der zivilisationsbedingten Strahlenexposition darstellen. Der heutige Mensch ist im Verlaufe seines Lebens also beiden Expositionsarten ausgesetzt. Diese Broschüre soll vor allem die Frage nach dem Wesen und dem Verhältnis der beiden Expositionsarten zueinander beantworten. Redaktionsschluss: 30.09.2014
306

Radon: Vorkommen - Wirkung - Schutz

14 September 2021 (has links)
In der Broschüre erhalten Sie Informationen zu den Eigenschaften, sein Vorkommen und Empfehlungen für den Umgang mit Radon. Radon ist ein radioaktives Edelgas. Es ist natürlichen Ursprungs und wird hauptsächlich aus dem Boden in die Luft freigesetzt. Deshalb wird Radon vom Menschen eingeatmet und kann Lungenkrebs verursachen. Der Mensch kann sich vor den schädlichen Wirkungen durch geeignete Maßnahmen schützen. Redaktionsschluss: 26.03.2019
307

Problematika prostřihování otvoru dvouvrstvým polotovarem / Hole punching problematics of two layered sheet metal

Kvapil, Štěpán January 2020 (has links)
The thesis is focussed on project of a tool – a hot working clipping punch, where the hole is punched in the upsetting ends of stabilizer. We talk about punching of a two layered semi-finished product, in which burr is formed at the layer interface, which is undesirable from the point of the customer requirement. The stabilizer is mounted in the car chassis, where it is fastened to the axle with screws. The literature study is focused on the theory and problems of punching. In the practical part, several design solutions of cutter faces are discussed, from which three types of face shape were selected. This was associated with a change in the design of the ejector. Two tool materials were selected for comparison. The cutters were tested on an automatic forming centre. Finally, after summarizing and evaluating all the practical experiments, an optimal solution of a tool designed for punching a hole with a two layered semi-finished product is proposed.
308

Siedlungsabfallbilanz

17 August 2011 (has links)
No description available.
309

Evaluation der ambulanten Hilfe zur Erziehung

Viererbl, Harro 30 March 2005 (has links)
Gegenstand dieser qualitätsideologiekritischen Studie sind Verfahren zur Evaluation sozialpädagogischer Dienstleistungen im Bereich der ambulanten Hilfen zur Erziehung nach dem Kinder- und Jugendhilfegesetz. Im Sog eines inflationären Qualitätsdiskurses hat sich eine Art pseudo-objektiver Scheinrealität entwickelt, hinter der sich auch interessengeleitete Anpassungsprozesse und die Intention zur Kostensenkung verbergen. Chancen und Begrenzungen teilweise fachfremder Ansätze zur Wirksamkeitsbewertung von Erziehungshilfemaßnahmen werden daher unter Berücksichtigung der Dynamik von Sub- und Suprasystemen des Praxisfeldes herausgearbeitet, um einer unreflektierten Qualitätsideologie realistische Sichtweisen von Bewertungsmöglichkeiten psychosozialer Beziehungsarbeit gegenüber zu stellen. Die Untersuchung von Relevanz und Praxistauglichkeit unterschiedlicher Verfahren und Ansätze für den spezifischen Bereich der ambulanten Hilfen zur Erziehung erfolgt anhand der Beschreibung ihrer Möglichkeiten das besondere Beziehungsgefüge und die Komplexität des Geschehens mehrperspektivisch zu erfassen.
310

„Allein machen sie dich ein“ – Soziale Arbeit und Gewerkschaften: Begründungen, Formen und Perspektiven gewerkschaftlichorganisierter Sozialer Arbeit

Hensel, Thomas 15 July 2015 (has links)
Soziale Arbeit als Erwerbstätigkeit und Sozialarbeiter_innen als lohnabhängige Beschäftigte zu betrachten, wird in Zeiten schwindender Tarifbindung sozialer Träger und der damit einhergehenden Prekarisierung und Deprofessionalisierung Sozialer Arbeit immer notwendiger. Gesellschaftliche, politische und wirtschaftliche Entwicklungen führen in das Thema ein und leiten zur Darstellung der Prekarisierungstendenzen Sozialer Arbeit als Erwerbstätigkeit und als Profession über. Daran anschließend wird der aktuelle Zustand gewerkschaftlicher Organisiertheit der Sozialen Arbeit und ihrer Fachkräfte dargestellt. Hauptschwerpunkt der Arbeit ist es, zu analysieren, warum Soziale Arbeit und Gewerkschaften in nur geringem Bezug zueinander stehen und warum Soziale Arbeit gewerkschaftlich nur marginal organisiert und repräsentiert ist. Fach- und tarifpolitische Interessen Sozialer Arbeit als Profession und als Erwerbstätigkeit gilt es in ihren Interdependenzen zu verstehen, nicht zuletzt, um die gewerkschaftliche Repräsentation Sozialer Arbeit und ihrer Fachkräfte zu erhöhen – im Sinne einer fachlich hochwertigen und professionellen Sozialen Arbeit.

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