Mobility has a vital impact on the quality of life in a city. Yet, traditional modes of car-centric transportation models generate large externalities that must be tackled by cities - such as congestion, noise and air pollution. The Free and Hanseatic City of Hamburg in Germany is striving for a mobility transition, making mobility more sustainable and environmentally friendly. The city wants to change the mobility behaviour by strengthening the means of transport that are causing less impact on the environment and climate. By 2030, the goal is to increase the share of cycling, walking and public transport to a total of 80 per cent of all routes travelled. Cycling, which is especially cost- and space-efficient, plays a crucial role here. More specifically, the share of all joumeys made by bike should be increased by 25-30 per cent within this decade. Within the framework of Hamburg's strategy of lntelligent Transport Systems (ITS), the city fosters, develops and conducts ITS-projects that focus, amongst others, on cycling. In order to increase the proportion of cycling, it is essential to promote its attractiveness. A cycling infrastructure that ensures smooth and easy cycling within the city is vital for a competitive alternative to motorised private transport. Furthermore, people enjoy cycling when they feel comfortable and safe [e.g. 3]. The ITS-project PrioBilce-HH follows this approach and addresses both topics: cycling comfort and safety. This abstract focuses on the aspect of safety.

Data about bicycle usage is an important input parameter for several purposes. They are used to describe changes towards more sustainable transport, and partly to say something about changes towards more active transport as opposed to passive modes oftransport. Importantly such data are used as the denominator when calculating crash risk: for cyclists. In Norway, as in most countries, these data are captured in several ways today. This is partly done by using data from the national travel behavior survey, partly using figures from stationazy or mobile bicycle counters, and partly using other methods such as manual counts, etc. The technological development has provided several new opportunities to register such travel, in the form of more advanced stationary counters, advanced algorithms that interprets signal data, video recording solutions and app-based measurement systems. At the sam.e time, we see that development in the transport sector also creates new challenges. In just a few years, electric scooters have radically changed the traffic picture in cities and towns in Norway. There is therefore a need for more knowledge about different forms of ways to measure bicycle and micro-mobility use, their strengths and weaknesses, and what kind of strategies the authorities should have to be equipped to meet future changes in the transport field, as exemplified by the recent intlux of e-scooters. The current paper aims to respond to these challenges by answering the following research questions: • What are the relative strengths and weaknesses of different data sources for measuring cycling and micromobility use? • How weil do the different sources function to capture micromobility and to differentiate between traditional cycling and micromobility? • How can the different data sources be used as input for calculating crash risk for various forms of soft mobility (i.e. cycling and micromobility)?

Visiting a museum is a popular activity for many people. Be it to find out about certain museum objects or to feel entertained. An important contribution to a satisfying museum experience is the information about the objects. On the one hand, the provided information should be about them, but at the same time reflect the interests of the visitor. Since the information presented on information labels is often only rudimentary, visitors can follow human guides or use digital tools that display additional information. The problem, however, that exists despite a wide range of offers, is that the information is designed for the general public and cannot be customized by the visitor. In this way, information is presented that is either not of interest to the visitor or, in the worst case, that the visitor does not understand because prior knowledge is lacking. Even if existing research deals with the presentation of information and the preparation of digital applications, the customizing aspect is often missing. This master thesis shows to what extent information and functions embedded in an app can be customized. A prototype of an app was constructed that, based on an example museum, presents filter options too utput customized information about a museum object. The prototype was tested in a user study by six participants. The participants tested the prototype by processing test tasks and answered an evaluation questionnaire. Three of the six participants also completed a group interview. The goal was to find out to what extent the filters offered reflect the needs of the participants and which functions and aspects are important for customization. The results show that despite the current lack of focus on prior knowledge, filtering based on it is not very effective. In addition, suggestions were made as to how groups could benefit from the more individual use of the app. Future research can build on the achieved results by integrating the proposed functions and testing them in further studies to expand the customization step by step.

Das gletscherähnliche und amorphe Modell “Supernatural - Polar“ für den Wettbewerb “Entdeckung“ ist aus meinem Konzept “SculptuReal“ 2019 entstanden. Um den Umgang mit künstlerischer Plastik für ein breiteres Publikum spannend und erfahrbar zu machen, entwarf ich eine App, mit der Skulpturen über das Interface eines Smartphones oder Tablets leicht “erspielt“ und durch das 3D-Druckverfahren ins Reelle übertragen werden können.

Syfte: Undersöka om det är möjligt att utveckla en mobilapplikation som utbildar personal och studenter inom det tandtekniska yrket kring avfallshantering av dentala material på ett lättförståeligt, visuellt tilltalande och motiverande sätt.   Metod: Produkter som kan användas vid såväl konstruktionsframställning som städning på tandtekniska laboratorium och på Odontologiska fakulteten fotograferades, och redigerades därefter genom flera redigeringsprogram. Med assistans av apputvecklare skapades en mobilapplikation där deltagarna erhöll sig lärandeinsatser för korrekt avfallshantering. Applikationen inkluderar sammanlagt 12 nivåer med totalt 118 olika produkter och objekt, fördelade över sju avfallstyper per nivå. Endast testgrupperna använde applikationen.   Kunskapsprov med totalt 20 quizfrågor indelat i två delar sammansattes, Single Best Answer och Multiple Choice Questions. Utvärderingsenkäten sammansattes med totalt 27 frågor.        Det anordnades två träffar med deltagarna. Första träffen: kunskapsprovet genomfördes för att fastställa utgångspunkten för samtliga deltagares kunskapsnivå, samt utlämning av studiematerial och APP. Andra träffen: kunskapsprovet genomfördes igen för att fastställa kunskapsutvecklingen inom ämnet samt utvärderingsenkät av momentet genomfördes.   Resultat: Resultatet visade en sämre prestation på kunskapsproven för både kontroll- och testgrupper efter utlämning av studiematerial och APP. Provresultaten uppvisade ingen statistisk signifikant skillnad mellan grupperna.   Slutsats: Varken tillgång till säkerhetsdatablad eller mobilapplikation för utbildning i avfallshantering förbättrar kunskaperna för avfallshantering av dentala material. Den utvecklade mobilapplikationen upplevdes som motiverande, lättförståeligt och visuellt tilltalande av deltagarna. Samtliga deltagare var statistiskt enade att studiens ämne var intressant samt var positivt inställda till spelbaserat lärande. / Purpose: Investigate whether it is possible to develop a mobile application that educates staff and students in the dental technology profession in waste management of dental materials.   Method: Products utilized in dental laboratories were photographed then edited. Collaborating with an app developer, an application was created with educational materials on waste management. The application included 12 levels, featuring a total of 118 different products, distributed over seven waste types per level. Only the test groups used the application.   A knowledge test of 20 questions divided into two parts was developed: Single Best Answer and Multiple Choice Questions. A review form was developed, with a total of 27 questions.   Two sessions were scheduled with the participants. First session: the knowledge test was carried out to determine the baseline of knowledge, and study material and the APP were distributed. Second session: the test was carried out again to assess knowledge progression, and a review of the exercise was conducted.   Results: The results show worse performance for both test and control groups on the tests after handing over study material and APP. The test results showed no statistically significant difference between the groups.   Conclusion: Neither access to safety data sheets nor mobile application for education in waste management improves knowledge in waste management of dental materials. The developed mobile application was perceived as motivating, easy to understand and visually appealing by the participants. All participants were statistically in agreement that the study’s subject was interesting and had a positive attitude towards game-based learning.

Das Betriebssystem Android bietet, aufgrund der stetig steigenden Zahl der verfügbaren mobilen Geräte auf Basis dieses System und der ebenfalls stark steigenden Zahl der Nutzer solcher Geräte, eine sehr gute Grundlage zur Entwicklung diverser mobiler Anwendungen. Es kann dabei für jeden erdenklichen Bereich des alltäglichen Lebens, vor allem Freizeit, aber auch Arbeit, eine App auf Grundlage von Android entwickelt werden. Im Bereich der mobilen Eventguides gibt es aktuell noch Entwicklungsbedarf bei den angebotenen mobilen Applikationen. So gibt es zahlreiche Anwendungen für Messen, Konferenzen oder Festivals, allerdings unterscheiden sich diese stark in ihren Funktionen und vor allem in der Darstellung von Karten und Plänen. Häufig werden solche Apps auf Grundlage eines Frameworks erstellt, welches es ermöglicht die App an verschiedene Veranstaltungen anzupassen. Die vorliegende Arbeit beschreibt die Implementierung eines Konferenzführers für die Internationale Kartographische Konferenz 2013 in Dresden. Grundlage für die Implementierung ist dabei die Betrachtung von Orientierungsmethoden und Navigationsanwendungen für Fußgänger im In- und Outdoorbereich und auf Großveranstaltungen. Hierzu werden bereits vorhandene Apps aus dem Bereich Veranstaltungen untersucht. Neben den allgemeinen Funktionen wird ein Augenmerk auf die kartographischen Funktionen solcher Apps gelegt. Im Rahmen der Arbeit wird ein Framework, auf Basis von Android, entwickelt, welches die Erstellung von mobilen Anwendungen für verschiedene Großereignisse ermöglicht. Dieses Framework wird speziell an die Internationale Kartographische Konferenz 2013 angepasst und liefert als Ergebnis eine App, die als digitaler Konferenzführer genutzt werden kann. / The Android operating system offers, due to the increasing number of available mobile devices based on this system and also the rapidly increasing number of users of such devices, a very good basis for the development of various mobile applications. It can be relevant to every conceivable area of everyday life, especially leisure, but also work to develop an app based on Android. It currently still requires development of the offered mobile applications in the area of mobile event guides. There are numerous applications for trade shows, conferences and festivals, but they differ greatly in their functions and, above all in the presentation of maps and plans. Often, such apps are created based on a framework that allows the app to adapt to different events. The present paper describes the implementation of a conference guide for the International Cartographic Conference 2013 in Dresden. Basis for the implementation is the consideration of methods of orientation and navigation applications at indoor and outdoor areas for pedestrians and on major events. To this end, existing applications from the category large events will be studied. Besides the general features a focus is placed on the cartographic features of such apps. A framework, based on Android, which allows the creation of mobile applications for various large events, will be created as part of the work. This framework is adapted to the International Cartographic Conference 2013 and delivers as a result an application that can be used as a digital conference guide.

Målet med detta examensarbete har varit att ta fram en applikation föratt publicera kyrkoåret. Appen ska fungera i telefon och pekplatta förandroid. Till det kommer en webbsida som fungerar för datorer ochmobila enheter som inte kör android. Man skall även kunna få framdatan som en PDF (Portable Document Format) fil, XML (ExtensibleMarkup Language) fil och en ICAL (kalender) fil. I denna uppgift ingåräven att ta fram en databasstruktur, objektorienterad design för arbetetsamt val av system och databas. Arbetet har genomförts med hjälp avPHP (Hypertext Preprocessor), MYSQL, CSS (Cascading Style Sheets),etc. Appen och sidan är en användarvänlig sida med bra prestanda ochtydligt resultat för ändamålet det är till för. Jag har kommit fram till att det är svårt att göra en sida som fungerar100% i mobiler och i datorer med olika webbläsare. / The objective with this thesis was to develop an app for android and awebsite that works for computers and mobile devices that are notrunning android, in order to publish the Liturgical year. You should alsobe able to obtain the data as a PDF file, XML file and a calendar file. Thistask includes developing a database structure, object oriented design ofwork and choice of system and form the database layout. The work hasbeen developed with the help of PHP, MYSQL, CSS and so on. The appand the page is a user friendly site with good performance and clearresults for the purpose it brings. I have come to the conclusion that it is difficult to make a page thatworks 100% for mobile phone and computers with different browsers.

The polycystic ovary syndrome (PCOS) affects women or people with female reproductive organs negatively, by irregular periods, difficulties in getting pregnant, and excessive hair growth. The symptoms can be eased by taking on habits of regular physical exercise and a balanced diet. Taking on new habits is however a challenging task. This thesis aims at harnessing the affordances (if any) that the design of gamification in a mobile application for women with PCOS could bring. The theoretical lens of self-determination theory has been used to underpin the design of gamification elements that can engage the users of an app. After creating designs and implementations in the app, evaluations were made with 29 participants through surveys and interviews. The results from the user evaluations show that participants’ thoughts on features and elements differed and that they were interested in them being designed in different ways. Designing an app that allows the user flexibility was desirable, and even viewed as motivational. Another take is that one should be careful in designing elements in a health app that uses comparing elements of gamification, since it can generate negative feelings such as anxiety. In the future, it would be interesting to include more features in the app and let users test it for a longer time to see if that would have a significant impact on the user engagement, and if habits could form for a better well-being. / Polycystiskt ovarialsyndrom (PCOS) påverkar kvinnor eller människor med kvinnliga reproduktiva organ negativt, genom oregelbunden mens, svårigheter i att bli gravid, och ökad hårväxt. Symptomen kan lindras genom regelbunden fysisk aktivitet och en balanserad kost. Att skaffa nya vanor är en utmaning. Det här examensarbetet har i syfte att se vilka möjligheter (om några) som en design av spelifiering i en mobilapp för kvinnor med PCOS kan ge. Linsen av självbestämmande teorin har använts för att stödja designen av spelifiering element som kan engagera app användare. Utvärderingar gjordes med 29 deltagare i form av enkäter samt intervjuer efter att ha skapat designer samt gjort implementationer i appen. Resultaten, baserade på deltagar utvärderingarna, visar på att användarnas tankar kring funktioner och element skilde sig åt samt att de var intresserade i olika designer för dessa. Att designa en app som erbjuder användaren flexibilitet var önskvärt, och sågs även som motiverande. En annan insikt är att designa delar av en hälsoapp som använder sig av spelifiering element där man jämför sig med andra bör ske med omsorg, då det kan medföra användaren med negativa känslor såsom ångest. Vidare vore det intressant att inkludera fler funktioner i appen och låta användare testa den en längre period för att se om det skulle ha en signifikant påverkan på användarnas engagemang, samt om vanor kunde skapas för ett bättre välbefinnande.

隨著網際網路與資通訊科技的高度發展，企業打造多元的APP改變經營模式，同時政府機關為了提升政府運作效能與國家競爭力，亦設置了多元的行動化服務。新服務模式跨越了傳統時間與空間上的限制，對於傳統的代議政治體系中提供了更符合公民直接參與的機會。近年來，電子化政府的發展更被廣泛地賦予民主意涵，電子民主成為公民參與與政府治理之新溝通模式。 本研究透過電子公民參與相關研究文獻之彙整，盤點及歸類現行中央與地方政府所提供的APP服務與電子公民參與之間的關係。再者，根據分類的結果，針對擁有電子化決策參與精神的APP服務建構評估指標，本研究挑選臺北市長信箱以及阿倫Online作為參照個案，同時彙整網站服務品質指標、國內外電子化政府評估研究、政府服務滿意度評估研究、電子商務滿意度研究、首長信箱滿意度評估架構，以及結合網路資源等六類文獻，提出政府APP評估構面與操作化指標，並透過兩回合的結構式問卷訪談修改指標架構及內容。 本研究經結構式問卷訪談進行資料收集後，將政府APP評估構面與操作化指標區分為兩大主構面：系統品質以及公民參與與服務品質。前者，進一步細分出（1）視覺設計、（2）易用性、（3）安全及隱私等三大次構面，其中，視覺設計共有九項指標，如：APP名稱清楚明確，並能凸顯其具備陳情抱怨的特質、APP簡單整潔；易用性共有十九項指標，如：APP在點選後3秒內，能執行完畢、APP的功能簡單、便利；安全及隱私共有四項指標，如：APP所需的資訊與權限可以被接受、APP所需的個人資料項目可以被接受。 後者，細分出（1）互動及回覆內容品質、（2）有用性、（3）反應性、（4）效能感等四大次構面。其中，互動及回覆內容品質共有四項指標，如：主管單位回覆的資訊是充足的、主管單位的回覆是正確的；有用性共有三項指標，如：相較於臨櫃服務、1999與網頁版首長信箱，APP能更快速解決我陳情抱怨的問題、無須再透過其他系統或平台申辦帳號密碼，便可完成陳情抱怨程序；反應性共有六項指標，如：透過APP，政府機關能快速地接收到我的陳情、主管單位的回覆語氣與方式親切有禮；效能感共有三項指標，如：陳情通知或回覆的內容，讓我覺得主管單位了解我的困難及問題癥結、我認為主管單位的通知或回覆內容係針對我的需求與問題提供服務。總計有二大主構面、七大次構面，以及四十七項指標。同時依據每項指標對於APP意義程度上的差異，將指標區分為基本指標（must have）以及進階指標（good to have）兩種層次。 期望本研究建構的指標架構，除了可做為未來政府機關開發電子化決策參與APP的參考依據外，同時有助於主管機關改善及永續現行APP之經營與發展，並且強化APP的安全機制，邁向資訊開放及運用。後續研究可深入探討無障礙與安全性指標內容設計，待部分指標進一步操作化後，可運用德菲法讓指標項目具一致性，並採用AHP搭配深度訪談擬定指標權重，最終以大量發放問卷了解指標合適度以及了解APP的發展現況。 / The expansion of the Internet and the fast development of information communication technologies (ICTs) have changed service deliveries of enterprises and government organizations. Many enterprises change the service model with creating a variety of APPs. Government organizations, meanwhile, provide multiple mobile services in order to maximize the competitive advantage of nations. A novel service model breaks restrictions on time and space, providing the opportunity of direct democracy for the public. Lately, the development of electronic government is entitled to extensive democracy, and electronic government becomes a new communication model. In order to realize the meaning of e-democracy and the development of governments’ online services, this research reviews the literature of electronic democracy. The author use three dimensions, including ‘electronic information’, ‘electronic service and consultation’, and ‘electronic decision making and participation’, to categorize APPs created by central and local governments. Base on the previous findings, this research selects electronic decision making and participation of APPs to construct indicators. The author reviews six types of literatures, including web service quality indicators, electronic government assessment, governmental service quality research, electronic commerce satisfaction, mayor's email-box satisfaction, and Internet resources to establish indicators of governments’ APPs. The framework and contents of indicators are revised by implementing two rounds in-depth interviews with the questionnaire. According to empirical data, this research separate indicators into two dimensions, including System Quality and Citizen Participation & Service Quality. The System Quality has three sub-dimensions, including Visual Design, Ease of Use, and Security & Privacy. Visual Design has nine indicators, such as the accuracy of APPs’ title, the simplicity of APP, etc. Ease of Use has nineteen indicators, such as the response time less than three seconds, the simplicity of APPs’ functions, etc. Security & Privacy has four indicators, such as the authority of being acceptable, proper personal informations, etc. The Citizen Participation & Service Quality has four sub-dimensions, including the Contents’ Quality of Interactions, Usability, Responsiveness, and Efficacy. The Contents’ Quality of Interactions has four indicators, such as the sufficiency of governments’ reply, the accuracy of governments’ reply, etc. Usability has three indicators, such as relative to APPs’ deal of speed than counters, 1999, and the mayor's email-boxes, applying for accounts directly in APP, etc. Responsiveness has six indicators, such as immediately response, courteous reply, etc. Efficacy has three indicators, such as understanding of the petition, customize services, etc. To sum up, indicators of government APPs have two dimensiosns, seven sub-dimensiosns and forty eight indicators. Base on those indicators, and this research further categorizes them into ‘must have’ and ‘good to have’. This framework of indicators is expected not only becoming the reference for government organizations creating APPs in the future but also improving service quality of APPs nowadays. Moreover, it is important that having to strengthen APP’s security and privacy, then governments could open data from citizen complaints and use them to create new value. Future research could explore the disability and security aspects of indicators. Moreover, future research could consider operationalize a part of indicators, and then adopt Delphi and AHP to measure robustly the consistency and weighting of indicators. Finally, the author expects the follow-up studies could conduct questionnaires to realize the fitness for indicators and condition of APP’s development.

Un ensemble des données cohérentes de la littérature plaide en faveur d'une relation entre une baisse d'activité de la voie de signalisation de la vitamine A, des altérations de la plasticité synaptique et des déficits mnésiques spécifiques associés au vieillissement. Une diminution de l'activité de cette voie de signalisation est également évoquée dans les processus neurodégénératifs caractéristiques de la maladie d'Alzheimer. Dans ce contexte, les objectifs de ce travail étaient de mieux comprendre les conséquences neuro-anatomiques et fonctionnelles d'une baisse d'activité de la voie de signalisation de la vitamine A. Notre approche expérimentale a mis en œuvre 2 modèles animaux, un modèle de carence vitaminique A qui induit spécifiquement une baisse d'activité de sa voie de signalisation et un modèle d'hypothyroïdie dont il a été montré qu'il induit aussi une hypoactivité de la voie de signalisation de la vitamine A. La démarche expérimentale conduite chez les rats carencés en vitamine A comporte deux volets : (i) un volet mettant en œuvre l’imagerie et la spectroscopie RMN, (ii) un volet moléculaire consacrée à l’étude de l’expression de gènes cibles des rétinoïdes impliqués dans le processus amyloïdogène. Les mesures ont été réalisées, d'une part, chez des animaux soumis à un régime dépourvu en vitamine A pendant 10 semaines et d'autre part, chez des animaux soumis à ce même régime pendant une durée de 13 ou 14 semaines. Une partie des animaux carencés a été traitée par de l'AR. Les résultats montrent que dès 10 semaines de carence, les animaux présentent une altération du métabolisme et de son action cellulaire de la vitamine A qui se traduit par (i) une diminution significative du taux de vitamine A sérique, (ii) une diminution du taux d'ARNm codant pour les récepteurs RAR, dans le cerveau entier, le striatum, l'hippocampe et de manière moins prononcée le cortex des animaux. Après 10 semaines de régime dépourvu en vitamine A, des modifications métaboliques ont été mises en évidence essentiellement dans le cortex. Elles se traduisent par une hausse du (i) NAA/Cr, marqueur de la densité neuronale corrigée par une administration d'AR, et (ii) du GSH/Cr, indicateur du potentiel antioxydant cellulaire dans cette structure. Au plan anatomique, un ralentissement de la croissance cérébrale a été observé dés la 7ème semaine de régime. Une diminution du volume hippocampique et une augmentation des espaces ventriculaires ont été observées à partir de 11 semaines de carence. Au plan moléculaire, aucune modification de l'expression du gène codant pour APP, ou du rapport APP770-751/APP695, considéré comme un indicateur précoce de la MA n'a été observée après 10 semaines de carence. Après 14 semaines de régime dépourvu en vitamine A, de profondes modifications métaboliques sont observées dans les trois structures à savoir le cortex, l’hippocampe et le striatum. Au plan moléculaire, les principaux résultats suggèrent un basculement du processus biochimique de dégradation de la protéine APP en faveur de la voie amyloïdogénique dans le cortex, et par voie de conséquence en faveur de la formation du peptide Aß. Cependant, aucune modification du taux protéique des peptides Aß n'a été mise en évidence dans le cortex et l'hippocampe des rats carencés. Le modèle d'hypothyroïdie que nous avons mis en oeuvre entraine bien une hypoactivité de la voie de signalisation de la T3, observée dans l'hippocampe des animaux et une diminution du taux d'ARNm codant pour RARß observée dans le cortex des rats hypothyroïdiens. Au plan moléculaire, l'augmentation du rapport APP770-751/APP695 a été observée chez les rats rendus hypothyroïdiens par rapport aux rats témoins. Comme chez les rats carencés en vitamine A, les indicateurs de la voie physiologique ne sont que très faiblement affectés chez les rats rendus hypothyroïdiens. / Some data reveal that retinoid hyposignalling, presumably resulting from decreased bioavailability of retinoid ligands naturally, was shown to result in aging-related synaptic plasticity and long term potentiation (LTP) alterations as well as in aging-related decline of cognitive function. Moreover, genetic, metabolic and dietary evidence has been provided for a defective retinoid metabolism in Alzheimer disease (AD). Thus, key steps of the amyloid production process are under the control of proteins whose expression is positively regulated by RA in vitro. In this context, the aims of this work were to better understand neuro-anatomical and functionnal consequences of retinoid signaling brain hypoactivity. Our experimental method uses two animal models: a Vitamin A deficiency model which induce especially an hypoactivity of retinoid pathway, and an hypothyroid model which was also characterized by an hypoactivity of retinoid pathway. In the fisrt model, two main approch were used : (i) an NMR imaging and spectroscopy approach, (ii) a molecular approach to study expression of retinoid target genes implicated in amyloidogenic process. NMR results showed that VAD induces severe anatomic and metabolic disorders in particular a slowing of brain growth, hippocampus atrophy, and a decrease of NAA/Cr, marker of neuronal density which was observed in cortex, hippocampus and striatum. Molecular results reveal a vitamin A deficiency-related dysregulation of the amyloid pathway in the cortex of rats, which is known to be the first brain area altered by AD development. In this area, 14 weeks of deprived diet induces physiological dysregulation in the modulation of RA target genes leading to an increased amount of ADAM10, BACE and PS1, with some modifications in amyloidogenic pathway but without increased amount of Aß peptides. In hypothyroid model, molecular results suggests that adult onset-hypothyroidism may induce the amyloidogenic pathway of APP processing by increasing activity of ß and ?secretases and levels of amyloid peptides mainly in hippocampus. Together these data argue for the idea that hypoactivity of retinoid signalling which occurs naturally with aging could be a factor participating in accelerating aging and that hypothyroidism that become more prevalent with advancing age, could increase, via a hyposignaling of T3 pathway, the vulnerability of amyloidogenic pathway of APP processing as well as of other clinical symptoms of AD.