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41	Spolupráce rodiny a školy na počátku vzdělávání / Cooperation of family and school at the beginning of schooling Dušková, Tereza January 2011 (has links) Name: Cooperation of family and school at the beginning of schooling Author: Dušková, T. Supervisor: Mgr. Kargerová, J., Ph.D. The diploma thesis is focused on the cooperation of family and school at the beginning of schooling. The theoretical part describes the school and the family as the institutions that have an irreplaceable position in a life of child. It offers a view into the history and its forms of cooperation and aims which were reached in compare with today's understanding of the child and childhood. It deals with 1989 and its events which influenced the politic, economic and pedagogic situation - the child is in the middle of the family a school attention. The education is innovated, reformatted and new laws together with some new school programmes are issued. The theoretical background is finished by a description of Začít spolu program, its brief characteristic and concrete forms of cooperation with families. The empiric part surveys the situation in an ordinary school and the school worked according to the Začít spolu program. It compares their elementary and secondary levels and it offers some recommendations for better family-school cooperation.
42	Desenvolvimento de pele humana reconstruída contendo equivalente dérmico glicado na avaliação da eficácia e toxicidade de compostos anti-glicação / Development of reconstructed human skin containing glycated dermal equivalent to toxicity and efficacy tests of anti-glycation compounds Paula Comune Pennacchi 03 February 2016 (has links) A glicação não enzimática das proteínas é um fator comum para a fisiopatologia de uma série de transtornos relacionados ao envelhecimento e a doenças como o diabetes mellitus (DM). O geração dos produtos de glicação, os AGEs (do inglês: Advanced Glycation End Products) se dá através de reações de glicação da mariz extracelular (MEC) na derme e têm sido apontado como um dos fatores responsáveis pela perda de elasticidade e deficiência de cicatrização da pele. A permeação cutânea de compostos anti-AGE é uma limitação importante para eficiência terapêutica de compostos que devem atingir camadas mais profundas da pele. Modelos de pele reconstruída contendo equivalente dérmico glicado são estruturas tridimensionais geradas in vitro que mimetizam a pele humana e representam um eficiente modelo para o estudo de células e modificações provocadas na MEC no processo de envelhecimento e DM. O modelo 3D de pele reconstruída tem características metabólicas, de permeabilidade e atividade semelhantes à da pele original, potencializando seu papel nas investigações sobre permeabilidade de drogas, toxicidade, irritação, eficácia e segurança de compostos e diferenciação de queratinócitos. Uma série de compostos naturais ou sintéticos inibidores de AGEs têm sido descobertos e apresentados recentemente e podem representar inovação terapêutica no tratamento de modificações causadas pela a formação e acúmulo destes AGEs também na pele. Este estudo avaliou o desenvolvimento da pele reconstruída glicada e posteriormente, a avaliação da eficácia e toxicidade de compostos anti-glicação como aminoguanidina e carnosina em modelo de pele reconstruída glicada. Em perspectiva, este estudo contribuiu para o desenvolvimento de uma nova tecnologia in vitro, a pele reconstruída glicada, que auxiliará a compreensão da biologia da interação célula-MEC mimetizando processos fisiopatológicos importantes como o envelhecimento e o DM. / The Advanced Glycation End Products (AGEs) of proteins is a common factor to the pathophysiology of a number of disorders related to aging and diseases such as diabetes mellitus (DM). The generation of the AGEs products on skin occurs mainly through non-enzymatic glycation reactions of the dermal extracellular matrix and has been touted as one of the factors responsible for loss of elasticity and disability of skin healing. The skin permeation of compounds is an important limitation for therapeutic/cosmetic efficacy of anti-AGE compounds, which must reach the deepest layers of the skin. Reconstructed skin model containing dermal equivalent modified by in vitro glycation is able to mimic the elderly human skin and represent an efficient model for the study of cells interactions and changes in extracellular matrix induced by aging and diabetes. The 3D reconstructed skin model has metabolic characteristics, permeability and activity similar to the original skin, reinforcing its role in drug permeability of investigations toxicity, irritation, safety and efficacy evaluation of compounds and differentiation of keratinocytes. A number of natural or synthetic AGEs inhibitor compounds have been recently discovered and displayed and can represent therapeutic innovation for the treatment of changes caused by the aging of the skin. In this study we performed the development of reconstructed glycated skin model and evaluated the efficacy and toxicity of anti-glycation compounds such as aminoguanidine and carnosine. In perspective, this study has contributed to the development of a new technology in vitro, and for the understanding cell-extracellular matrix interaction during the aging of skin. Diabetes mellitus Envelhecimento da pele Pele humana reconstruída Produtos finais de glicação avançada Advanced glycation end products Diabetes mellitus Reconstructed human skin Skin aging
43	Přínos dramapedagogiky pro výuku němčiny u žáků se speciálními poruchami učení. Projekt akčního výzkumu. / Drama-based Pedagogy Asset to German Education of Children with Learning Disabilities. Pedagogical Action Research Project. Melicharová, Vanda January 2017 (has links) Keywords action research, drama-based pedagogy, holistic pedagogy, activity based teaching, learning disabilities Abstract The thesis deals with the process of pedagogical qualitative action research and its results. The action research has a form of a case study, it examines influence of drama-based pedagogy on speech skills of children with learning disabilities at German lessons at hotel high school. Its objective is to improve the teacher's quality of teaching. As a part of the action research, the opinion survey data on drama-based pedagogy and experience with it was collected from other teachers of German language.
44	Technické ukazatele hodnocení tradičních a alternativních způsobů odkanalizování / Technical indicators for the evaluation of traditional and alternative drainage ways Kudrnová, Eliška January 2014 (has links) In the last years, we indicated progress in use of alternative methods for drainage. Thanks the information from abroad we started design vacuum and pressure methods of drainage instead gravity ones. The main content of this script is especially point out deficiencies of nowadays used alternative methods for drainage, which we can defuse. Another important part is also design of suitable technical indicators describing these drainages.
45	Právní rámec řešení sporů z mezinárodního obchodního styku v České republice a ve Francii / Legal framework of international trade disputes resolution in the Czech republic and in France Fuchsová, Michaela January 2016 (has links) LEGAL FRAMEWORK OF INTERNATIONAL TRADE DISPUTES RESOLUTION IN THE CZECH REPUBLIC AND IN FRANCE Comparative study of legal regulation in the Czech Republic and in France with emphasis on point of view of extent and limits of parties' autonomous will within dispute resolution ABSTRACT In relation to an important and continuously increasing growth of international trade and economic cooperation, a logic and proportionally increasing fact occurs, namely the existence and necessity of resolution of disputes arising out of such cooperation and business relationships. This dissertation focuses on specific area of such relations - on solution of property disputes in international trade and business relations arising out on private law basis between entrepreneurs and which affect in any manner the territories, more precisely the jurisdictions and the legal orders of two particular states, and that of France and the Czech Republic. The aim of the dissertation is to examine the extent of autonomous will, which the parties may assert within various methods of disputes resolution and to notify of its limits set by the respective legal regulation. Considering namely the main criteria of examination - i.e. the extent and limits of autonomous will of the parties within the dispute resolution - the author concentrates more...
46	CONSIDERAÇÕES SOBRE A RESOLUÇÃO CNJ n° 125/2010: uma avaliação política da política judiciária brasileira a solução dos conflitos de interesses? Aquino, Maria da Glória Costa Gonçalves de Sousa 26 February 2016 (has links) Made available in DSpace on 2016-08-18T18:53:57Z (GMT). No. of bitstreams: 1 Tese-MariadaGloriaAquino.pdf: 3535193 bytes, checksum: d6fa3018b98f4433417a29fca8640dc0 (MD5) Previous issue date: 2016-02-26 / This thesis aims at studying the Public Politics of the Brazilian Law Power and its focal point lies in the investigation of the political avaliation of the public politics of the unjudicialization of the interest conflicts, from the determinations established by the CNJ n° 125/2010 Resolution, which defined a new agreement in the performance of the Brazilian law activity, because of the implementation of consensual mechanisms of solution of litigations like the conciliation and the mediation The matter is analyzed from the historical perspective of the mutations of the state in its several structural versions. Moreover it influenced the functioning of the state political institutions. In the same scientific-historical chain it is analyzed the political function exerted by the state organs, focusing especially the political-institutional performance of the Law Power. In this point it is scrutinized the several classic paradigms which justify the separation of the state political powers and also intend the re-dimensionship of the functions exerted by the state. It is examined the political descentralization of the state powers in order to understand how those classic theories influenced the move of expansion of the Law Power in the structure of the Contemporary State, so enabling the exercise of the precipuons functions of the judging according to the laws, which are elaborated and created by the Legislative Power, but which themselves conditioned and submitted to the constitutional supremacy. It is made a field research from the intensification of the law performance, from the enlarged participation of the Law Power in the decisory processes in the contemporary democratic societies, in order to justify how that move promoted the judicalization and effective law activity. It is investigated the historical course of the intensification process of the law activity in Brazil, so making clear the law monopoly, moreover from the process of redemocratization of the land, whose milestone was determined through the promulgation of the Constitution of the Brazilian Federal Republic of 1988. It is presented the causes of the crisis of the Brazilian law function, emphasized by the broad processual congestion passed from the enlarged access to justice; and also the consequences fighted by the Law Power because of the problem of the excessive processual litigation and the frequent slowness of the law services, which are reflected in the determination and results obtained in the Court Reports in their numbers presented by the Law National Council. Avaliation of the originary precedents, of the formulation and the fundamentals of the public politics ofadequated treatment of interest conflicts, like a way of overcoming the mechanism of the adjudicated solution of the conflicts and aspiration to the reduction of the traditional processual demand, so enabling gradually the unjudicialization of the conflict. Equally, it is avaliated the framework of politics and the determination of their actors, included the receivers of the politics, the institutional subjects, and get the other involved in the process. It is analyzed the structure of the Permanent Uncleuses of Consensual Methods of Conflict Solution and also Citizenship, as well as its compositions, selection criteria, ways of implantation, goals and established directives by politics. Finally, it is developed an analysis on the politics perspectives, considering then the need of the redimension of the performance of the Law Power, having as basis the statistical indicators, those one more recent published by the National Council of Justice. This one enables the building of a new politics, motivated by its continuing construction and by its permanent reavaliation, so in order to make possible to get a more democratic process and involved by a precise law order, which can get a way more and more enlarged by law; and also can find pointed in an agile procedure, quick and, above all, prone to reduct the law demand, including the satisfaction of the involved ones and the modification of the social reality. / Esta tese tem como objeto o estudo da Política Pública do Poder Judiciário Brasileiro, e seu escopo se centraliza na investigação da avaliação política da política pública de desjudicialização dos conflitos de interesses, a partir das determinações estabelecidas pela Resolução CNJ n° 125/2010, que definiu um novo arranjo na atuação da atividade judiciária brasileira em razão da implementação de mecanismos consensuais de solução de litígios, como a conciliação e a mediação. A questão é analisada a partir da perspectiva histórica das mutações do Estado, em suas diversas versões estruturais que, sobremaneira, influenciaram o funcionamento das instituições políticas estatais. No mesmo encadeamento histórico-científico, analisa-se a função política exercida pelos órgãos estatais, com enfoque especial na atuação político-institucional do Poder Judiciário. Nessa seara, perscrutam-se os diversos paradigmas clássicos que justificam a separação dos poderes políticos estatais e que pretendem o redimensionamento das funções exercidas pelo Estado. Examina-se a descentralização política dos poderes estatais para compreender como essas teorias clássicas influenciaram o movimento de expansão do Poder Judiciário na estrutura do Estado contemporâneo, possibilitando o exercício da função precípua de julgar de acordo com as leis, as quais são elaboradas e criadas pelo Poder Legislativo, mas que se encontram sempre condicionadas e subordinadas à supremacia constitucional. Pesquisa-se a intensificação da atividade judicial a partir da participação ampliada do Poder Judiciário nos processos decisórios nas sociedades democráticas contemporâneas, para justificar como esse movimento promoveu a judicialização e um efetivo ativismo judicial. Percorre-se a trajetória histórica do processo de intensificação da atividade judiciária no Brasil, evidenciado pelo monopólio jurisdicional, sobretudo a partir do processo de redemocratização do país, cujo marco se determinou pela promulgação da Constituição da República Federativa do Brasil de 1988. Apresentam-se as causas da crise da função jurisdicional brasileira, evidenciada pelo largo congestionamento processual decorrente do acesso ampliado à Justiça e as consequências enfrentadas pelo Poder Judiciário em razão do problema da excessiva litigiosidade processual e da frequente morosidade da atividade judiciária, as quais se encontram refletidas nas determinações e resultados obtidos nos Relatórios Justiça em Números do Conselho Nacional de Justiça (CNJ). Avaliação dos antecedentesoriginários, da formulação e dos fundamentos da política pública de tratamento adequado dos conflitos de interesses, como meio de superação do mecanismo da solução adjudicada dos conflitos e com aspiração à redução da demanda processual tradicional, ensejando, gradativamente, a desjudicialização do conflito. Igualmente, avalia-se o arcabouço da política e as determinações de seus atores, incluindo os destinatários da política, os sujeitos institucionais e, ainda, os demais envolvidos no processo. Analisa-se a estruturação dos Núcleos Permanentes de Métodos Consensuais de Solução de Conflitos e dos Centros Judiciários de Solução de Conflitos e Cidadania, bem como suas composições, critérios de seleção, forma de implantação, objetivos e diretrizes estabelecidas pela política. Finalmente, desenvolve-se uma análise das perspectivas da política, considerando a necessidade do redimensionamento da atuação do Poder Judiciário, tendo como base os indicadores estatísticos mais recentes divulgados pelo Conselho Nacional de Justiça (CNJ), que enseja a edificação de uma nova política motivada por sua contínua construção e por sua constante reavaliação, de modo a viabilizar um processo mais democrático e envolto em uma ordem jurídica justa, que possibilite o acesso cada vez mais ampliado à justiça, e que se encontre pautado num procedimento ágil, célere e, acima de tudo, tendente à redução da demanda judicial, à satisfação dos envolvidos e à modificação da realidade social. Política Pública Poder Judiciário Política Pública Judiciária Nacional Monopólio Jurisdicional Acesso à Justiça Ativismo Judicial Desjudicialização Conselho Nacional de Justiça Celeridade processual Resolução CNJ n° 125/2010 Public Politics Law Power National Law Public Politics Acess to Law Law Performance Unjudicialization Law National Council
47	Development of Sensitive In Vitro Assays to Assess the Ocular Toxicity Potential of Chemicals and Ophthalmic Products McCanna, David January 2009 (has links) The utilization of in vitro tests with a tiered testing strategy for detection of mild ocular irritants can reduce the use of animals for testing, provide mechanistic data on toxic effects, and reduce the uncertainty associated with dose selection for clinical trials. The first section of this thesis describes how in vitro methods can be used to improve the prediction of the toxicity of chemicals and ophthalmic products. The proper utilization of in vitro methods can accurately predict toxic threshold levels and reduce animal use in product development. Sections two, three and four describe the development of new sensitive in vitro methods for predicting ocular toxicity. Maintaining the barrier function of the cornea is critical for the prevention of the penetration of infections microorganisms and irritating chemicals into the eye. Chapter 2 describes the development of a method for assessing the effects of chemicals on tight junctions using a human corneal epithelial and canine kidney epithelial cell line. In Chapter 3 a method that uses a primary organ culture for assessing single instillation and multiple instillation toxic effects is described. The ScanTox system was shown to be an ideal system to monitor the toxic effects over time as multiple readings can be taken of treated bovine lenses using the nondestructive method of assessing for the lens optical quality. Confirmations of toxic effects were made with the utilization of the viability dye alamarBlue. Chapter 4 describes the development of sensitive in vitro assays for detecting ocular toxicity by measuring the effects of chemicals on the mitochondrial integrity of bovine cornea, bovine lens epithelium and corneal epithelial cells, using fluorescent dyes. The goal of this research was to develop an in vitro test battery that can be used to accurately predict the ocular toxicity of new chemicals and ophthalmic formulations. By comparing the toxicity seen in vivo animals and humans with the toxicity response in these new in vitro methods, it was demonstrated that these in vitro methods can be utilized in a tiered testing strategy in the development of new chemicals and ophthalmic formulations. in vitro Alternative Methods alamarBlue rhodamine tight junctions bovine lens viability toxicity mitochondria mitochondria integrity benzalkonium chloride sodium dodecyl sulphate sodium lauryl sulfate scanning electron microscopy Draize Draize maximal average scores zonula occludens cosmetic directive PETA humane society animal league ICCVAM ECVAM JaCVAM BCOP bovine cornea ocular irritants ocular irritation ocular toxicity human corneal epithelial cells vitro confocal confocal microscopy metabolic activity optical quality reactive oxygen species contact lens contact lens care solutions barrier function microbial keratitis mulitipurpose solutions tight junction cell damage claudin ZO-1 occludin MDCK Madin Madin-Darby canine kidney cells cornea human cornea human corneal epithelium epithelial cell line human corneal epithelial cell line sodium fluorescein sodium fluorescein permeability fluorescein permeability ocular surface cell monolayer Araki-Sasaki cell physiology risk assessment safety assessment ScanTox scanning laser lens epithelium corneal cells in vitro model ophthalmic formulations multiple instillation back vertex animal testing rabbit testing alternatives to animal testing cultured bovine lens toxicity of chemicals irritation irritants laser scanner organ culture delayed toxicity toxins hydrogen peroxide cornea toxicity cornea toxicity models prediction of human toxicity no observable adverse effect level lowest observable adverse effect level NOAEL LOAEL toxicity thresholds safety factors cornea uncertainty factors preservatives disinfectants ophthalmic products preclinical preclinical testing epithelial barrier drug penetration clinical confocal microscopy animal rights rabbit cornea human cornea human clinical effects toxic animal rights activist sensitive measures toxic effect toxicity threshold agar overlay agar diffusion agar overlay method agar diffusion method cytochrome cytochrome c apoptosis necrotic apoptotic necrosis caspase rhodamine 123 resazuran resorufin cell death cell viability metabolic dye microsomal microsomal enzymes cytotoxicity cytotoxic cytotoxic effect MTT XTT WST-1 plasma membrane mitochondrial mitochondrial morphology ocular toxicity potential ocular toxicity human corneal epithelial cell line confocal analysis corneal epithelium cell fluorescence alamarBlue assay rhodamine dye animal welfare toxic injury degraded mitochondria epithelial monolayer disinfectants membrane integrity eye toxicity eye viability dye toxicity in humans human toxicity effects on the mitochondria mitochondrial toxicity in vitro battery in vitro test battery ophthalmic eye drop direct contact product safety cytotoxicity potential molecular molecular biology refine reduce replace sensitivity and relevance sensitivity relevance rabbit ocular irritation test product development cytotoxicity models cytotoxicity alternative methods replacements for animal testing three r's beagle tiered testing tiered testing strategy replacements animal testing mechanistic toxicity cornea mitochondria dose response threshold Vision Science and Biology
48	Development of Sensitive In Vitro Assays to Assess the Ocular Toxicity Potential of Chemicals and Ophthalmic Products McCanna, David January 2009 (has links) The utilization of in vitro tests with a tiered testing strategy for detection of mild ocular irritants can reduce the use of animals for testing, provide mechanistic data on toxic effects, and reduce the uncertainty associated with dose selection for clinical trials. The first section of this thesis describes how in vitro methods can be used to improve the prediction of the toxicity of chemicals and ophthalmic products. The proper utilization of in vitro methods can accurately predict toxic threshold levels and reduce animal use in product development. Sections two, three and four describe the development of new sensitive in vitro methods for predicting ocular toxicity. Maintaining the barrier function of the cornea is critical for the prevention of the penetration of infections microorganisms and irritating chemicals into the eye. Chapter 2 describes the development of a method for assessing the effects of chemicals on tight junctions using a human corneal epithelial and canine kidney epithelial cell line. In Chapter 3 a method that uses a primary organ culture for assessing single instillation and multiple instillation toxic effects is described. The ScanTox system was shown to be an ideal system to monitor the toxic effects over time as multiple readings can be taken of treated bovine lenses using the nondestructive method of assessing for the lens optical quality. Confirmations of toxic effects were made with the utilization of the viability dye alamarBlue. Chapter 4 describes the development of sensitive in vitro assays for detecting ocular toxicity by measuring the effects of chemicals on the mitochondrial integrity of bovine cornea, bovine lens epithelium and corneal epithelial cells, using fluorescent dyes. The goal of this research was to develop an in vitro test battery that can be used to accurately predict the ocular toxicity of new chemicals and ophthalmic formulations. By comparing the toxicity seen in vivo animals and humans with the toxicity response in these new in vitro methods, it was demonstrated that these in vitro methods can be utilized in a tiered testing strategy in the development of new chemicals and ophthalmic formulations. in vitro Alternative Methods alamarBlue rhodamine tight junctions bovine lens viability toxicity mitochondria mitochondria integrity benzalkonium chloride sodium dodecyl sulphate sodium lauryl sulfate scanning electron microscopy Draize Draize maximal average scores zonula occludens cosmetic directive PETA humane society animal league ICCVAM ECVAM JaCVAM BCOP bovine cornea ocular irritants ocular irritation ocular toxicity human corneal epithelial cells vitro confocal confocal microscopy metabolic activity optical quality reactive oxygen species contact lens contact lens care solutions barrier function microbial keratitis mulitipurpose solutions tight junction cell damage claudin ZO-1 occludin MDCK Madin Madin-Darby canine kidney cells cornea human cornea human corneal epithelium epithelial cell line human corneal epithelial cell line sodium fluorescein sodium fluorescein permeability fluorescein permeability ocular surface cell monolayer Araki-Sasaki cell physiology risk assessment safety assessment ScanTox scanning laser lens epithelium corneal cells in vitro model ophthalmic formulations multiple instillation back vertex animal testing rabbit testing alternatives to animal testing cultured bovine lens toxicity of chemicals irritation irritants laser scanner organ culture delayed toxicity toxins hydrogen peroxide cornea toxicity cornea toxicity models prediction of human toxicity no observable adverse effect level lowest observable adverse effect level NOAEL LOAEL toxicity thresholds safety factors cornea uncertainty factors preservatives disinfectants ophthalmic products preclinical preclinical testing epithelial barrier drug penetration clinical confocal microscopy animal rights rabbit cornea human cornea human clinical effects toxic animal rights activist sensitive measures toxic effect toxicity threshold agar overlay agar diffusion agar overlay method agar diffusion method cytochrome cytochrome c apoptosis necrotic apoptotic necrosis caspase rhodamine 123 resazuran resorufin cell death cell viability metabolic dye microsomal microsomal enzymes cytotoxicity cytotoxic cytotoxic effect MTT XTT WST-1 plasma membrane mitochondrial mitochondrial morphology ocular toxicity potential ocular toxicity human corneal epithelial cell line confocal analysis corneal epithelium cell fluorescence alamarBlue assay rhodamine dye animal welfare toxic injury degraded mitochondria epithelial monolayer disinfectants membrane integrity eye toxicity eye viability dye toxicity in humans human toxicity effects on the mitochondria mitochondrial toxicity in vitro battery in vitro test battery ophthalmic eye drop direct contact product safety cytotoxicity potential molecular molecular biology refine reduce replace sensitivity and relevance sensitivity relevance rabbit ocular irritation test product development cytotoxicity models cytotoxicity alternative methods replacements for animal testing three r's beagle tiered testing tiered testing strategy replacements animal testing mechanistic toxicity cornea mitochondria dose response threshold Vision Science and Biology

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