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Background: Data on the impact of gender on mortality after radical cystectomy is conflicting. We investigated a large single center sample with long-term follow-up in order to determine the relationship between gender and outcome. Patients and Methods: A total of 1,184 consecutive patients who underwent radical cystectomy for high risk superficial or muscle-invasive urothelial or undifferentiated bladder cancer between 1993 and 2015 were stratified by gender. Demographic data was compared using Mann-Whitney U test, chi-square test, or Fisher exact test. Cox proportional hazard models were used for the analysis of competing risks and logit models were used for the prediction of the receipt of adjuvant cisplatin-based chemotherapy. Results: Female patients were older, healthier, less frequently current smokers and had more extravesical tumors. In the multivariate analyses, female gender was an independent predictor of (lower) non-bladder cancer (competing) mortality (hazards ratio [HR] 0.68, 95% CI 0.49–0.95, p = 0.0248) but no predictor of bladder cancer-specific mortality (HR in the full model 1.20, 95% CI 0.94–1.54, p = 0.15). Gender was no predictor of the receipt of adjuvant cisplatin-based chemotherapy. Conclusions: Female gender was associated with an increased risk of extravesical disease but was no independent predictor of bladder cancer-specific mortality. Anatomical differences might be a plausible explanation for these observations.

Background: Factors predicting survival in men with lymph node-positive prostate cancer are still poorly defined. Patients and Methods: 193 prostate cancer patients with histopathologically proven lymph node involvement with a median follow-up of 7.3 years were studied. 94% of patients received immediate hormonal therapy. Kaplan-Meier curves were calculated to evaluate overall survival rates and compared with the log-rank test. Cumulative disease-specific and competing mortality rates were calculated by competing risk analysis and compared with the Pepe-Mori test. Cox proportional hazard models were used to determine the independent significance of predictors of all-cause mortality. Results: Age (70 years or older vs. younger), Gleason score (8–10 vs. 7 or lower) and the number of involved nodes (3 or more vs. 1–2) were identified as independent predictors of all-cause mortality. When patients with 0–1 of these risk factors were compared with those with 2–3 risk factors, all-cause (rates after 10 years 21% vs. 71%, p < 0.0001), disease-specific (12 vs. 37%, p = 0.009) and competing mortality (9 vs. 33%, p = 0.02) differed significantly. Conclusions: Some of the excess mortality in patients with poor-risk lymph node-positive prostate cancer may be attributed to increased competing mortality, possibly caused by an interaction between comorbid diseases and hormonally treated persistent or progressive prostate cancer. / Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.

Der armenisch-türkische Konflikt ist eines der zentralen Themen in der armenischen Wochenzeitung Agos. Die Karikaturisten Aret Gicir, Ohannes Saskal und Sarkis Pacaci bebildern diesen Konflikt in der Sprache der Karikaturen. Die Zeitung ist dabei auch ein Medium für das kollektive Gedächtnis der Armenier in der Türkei und in der Diaspora. Die vorliegende Arbeit untersucht die Rolle der Karikaturen als Erinnerungsfiguren und die Rolle der Karikaturisten als Erinnerungsträger in den armenischen Medien, hier namentlich die Wochenzeitung Agos, für den kollektiven Konstruktionsprozess. Ohne Medien sind keine Erinnerungen möglich und Karikaturen sind ein Medium der Erinnerung. Die Karikaturisten Aret Gicir, Ohannes Saskal und Sarkis Pacaci verwenden unterschiedliche Techniken und Bildersprachen. Ihre Karikaturen gleichen Graffitis, Piktogrammen oder erotischen Darstellungen, sie sind Botschaften und Symbole einer kulturellen Hinterlassenschaft, so wird beispielsweise der tabuisierte Diskurs der Sexualität mit dem tabuisierten Diskurs des armenischen Genozids in der Türkei verbunden, ein Tabu wird durch ein anderes Tabu ersetzt. Die vorliegende Arbeit zeigt, dass die Karikaturisten die Funktion von modernen armenischen Aschugs, den Minnesängern der Gemeinschaft, übernehmen. Anstatt die Erinnerungen wie früher persönlich von Dorf zu Dorf tragen, oder wie im europäischen Mittelalter von Burg zu Burg, übernimmt diese Reise der Erinnerung die Zeitung Agos, um den Rezipienten mit Botschaften aus der Heimat zu versorgen. Durch die Zeitung wird der Rezipient an die (armenische) Vergangenheit erinnert. An diese Erinnerung wird versucht, die kollektive Gedächtnis der Armenier als Ersatz für das fehlende kommunikative Gedächtnis zu etablieren. / The Armenian-Turkish conflict is among the key subjects treated in the Armenian weekly Agos. The caricaturists Aret Gicir, Ohannes Saskal, and Sarkis Pacaci illustrate this conflict in the language of caricatures. The newspaper is thus also a medium for the collective memory of Armenians in Turkey and in the diaspora. This dissertation examines the role of caricatures as memory figures and the role of the caricaturists as carriers of memory in the Armenian media, here specifically the Agos weekly, for the collective process of construction. Memories are not possible without media, and caricatures are a medium of memory. The caricaturists Aret Gicir, Ohannes Saskal, and Sarkis Pacaci use different techniques and imagery. Similar to graffiti, pictograms, or erotic depictions, their caricatures are messages and symbols of a cultural legacy. The tabooed discourse on sexuality, for example, is related to the tabooed discourse of the Armenian genocide in Turkey; one taboo replaces another. This thesis shows that the caricaturists assume the function of modern Armenian ashughs, the bards of the community. Instead of the earlier practice of transmitting the memories personally from village to village, or from castle to castle, as was done in medieval Europe, this journey of remembrance is carried out by the Agos newspaper in order to provide recipients with messages from home. The newspaper serves to remind recipients of the (Armenian) past. Through this memory, an attempt is made to establish the collective memory of the Armenians as a substitute for the lacking communicative memory.

Composants de systèmes de sûreté nucléaire sont en général très fiable, ce qui conduit à une difficulté de modéliser leurs comportements de dégradation et d'échec en raison de la quantité limitée de données disponibles. Par ailleurs, la complexité de cette tâche de modélisation est augmentée par le fait que ces systèmes sont souvent l'objet de multiples processus concurrents de dégradation et que ceux-ci peut être dépendants dans certaines circonstances, et influencé par un certain nombre de facteurs externes (par exemple la température, le stress, les chocs mécaniques, etc.).Dans ce cadre de problème compliqué, ce travail de thèse vise à développer un cadre holistique de modèles et de méthodes de calcul pour l'analyse basée sur la fiabilité et la maintenance d'optimisation des systèmes de sûreté nucléaire en tenant compte des connaissances disponibles sur les systèmes, les comportements de dégradation et de défaillance, de leurs dépendances, les facteurs influençant externes et les incertitudes associées.Les contributions scientifiques originales dans la thèse sont:(1) Pour les composants simples, nous intégrons des chocs aléatoires dans les modèles de physique multi-états pour l'analyse de la fiabilité des composants qui envisagent dépendances générales entre la dégradation et de deux types de chocs aléatoires.(2) Pour les systèmes multi-composants (avec un nombre limité de composants):(a) un cadre de modélisation de processus de Markov déterministes par morceaux est développé pour traiter la dépendance de dégradation dans un système dont les processus de dégradation sont modélisées par des modèles basés sur la physique et des modèles multi-états; (b) l'incertitude épistémique à cause de la connaissance incomplète ou imprécise est considéré et une méthode volumes finis est prolongée pour évaluer la fiabilité (floue) du système; (c) les mesures d'importance de l'écart moyen absolu sont étendues pour les composants avec multiples processus concurrents dépendants de dégradation et soumis à l'entretien; (d) la politique optimale de maintenance compte tenu de l'incertitude épistémique et la dépendance de dégradation est dérivé en combinant schéma volumes finis, évolution différentielle et non-dominée de tri évolution différentielle; (e) le cadre de la modélisation de (a) est étendu en incluant les impacts des chocs aléatoires sur les processus dépendants de dégradation.(3) Pour les systèmes multi-composants (avec un grand nombre de composants), une méthode d'évaluation de la fiabilité est proposé considérant la dépendance dégradation en combinant des diagrammes de décision binaires et simulation de Monte Carlo pour réduire le coût de calcul. / Components of nuclear safety systems are in general highly reliable, which leads to a difficulty in modeling their degradation and failure behaviors due to the limited amount of data available. Besides, the complexity of such modeling task is increased by the fact that these systems are often subject to multiple competing degradation processes and that these can be dependent under certain circumstances, and influenced by a number of external factors (e.g. temperature, stress, mechanical shocks, etc.). In this complicated problem setting, this PhD work aims to develop a holistic framework of models and computational methods for the reliability-based analysis and maintenance optimization of nuclear safety systems taking into account the available knowledge on the systems, degradation and failure behaviors, their dependencies, the external influencing factors and the associated uncertainties.The original scientific contributions of the work are: (1) For single components, we integrate random shocks into multi-state physics models for component reliability analysis, considering general dependencies between the degradation and two types of random shocks. (2) For multi-component systems (with a limited number of components):(a) a piecewise-deterministic Markov process modeling framework is developed to treat degradation dependency in a system whose degradation processes are modeled by physics-based models and multi-state models; (b) epistemic uncertainty due to incomplete or imprecise knowledge is considered and a finite-volume scheme is extended to assess the (fuzzy) system reliability; (c) the mean absolute deviation importance measures are extended for components with multiple dependent competing degradation processes and subject to maintenance; (d) the optimal maintenance policy considering epistemic uncertainty and degradation dependency is derived by combining finite-volume scheme, differential evolution and non-dominated sorting differential evolution; (e) the modeling framework of (a) is extended by including the impacts of random shocks on the dependent degradation processes.(3) For multi-component systems (with a large number of components), a reliability assessment method is proposed considering degradation dependency, by combining binary decision diagrams and Monte Carlo simulation to reduce computational costs.

HR-avdelningars roll är att tillgodose medarbetarnas, chefers och organisationens behov och utveckla de mänskliga- och organisatoriska resurserna. Det verkar vara vanligt att tro att de ekonomiska resurserna är viktigast för en organisations överlevnad, men medarbetares prestationer kan direkt påverka organisationers konkurrenskraft. Syftet var att utifrån ett HR-perspektiv öka förståelsen för organisationskultur och motivation och beskriva vad som utgjorde en innovativföretagskultur samt vilken roll arbetsmotivation hade för ett innovativt arbetsbeteende. Genom ett bekvämlighetsurval intervjuades åtta respondenter inom innovativa företag. En tematisk analys användes för att analysera intervjuerna och resulterade i två huvudteman som var innovativ företagskultur och motivation. Förutsättningarna för innovativa kulturer och beteenden samt motivation visade sig bero på graden av autonomi, socialt stöd och upplevelsen av kompetens samt återkoppling i arbetet. Autonomi och återkoppling var sätt för medarbetare att få tillåtelse att våga testa samt utvärdera sina innovativa idéer, vilket kunde leda till en mer autonom motivation och främja innovationskraften. Arbete med organisationskultur och motivation skulle kunna vara användbara sätt för HR-avdelningar och organisationer att arbeta för att behålla och förstärka sin position på marknaden.

Enzymes are useful tools as specific analytical reagents. Two different analysis methods were developed for use in the separate fields of protein science and organic synthesis. Both methods rely on the substrate specificity of enzymes. Enzyme catalysis and substrate specificity is described and put in context with each of the two developed methods. In paper I a method for C-terminal peptide sequencing was developed based on conventional Carboxypeptidase Y digestion combined with matrix assisted laser desorption/ionization mass spectrometry. An alternative nucleophile was used to obtain a stable peptide ladder and improve sequence coverage. In paper II and III, three different enzymes were used for rapid analysis of enantiomeric excess and conversion of O-acylated cyanohydrins synthesized by a defined protocol. Horse liver alcohol dehydrogenase, Candida antarctica lipase B and pig liver esterase were sequentially added to a solution containing the O-acylated cyanohydrin. Each enzyme caused a drop in absorbance from oxidation of NADH to NAD+. The conversion and enantiomeric excess of the sample could be calculated from the relative differences in absorbance. / QC 20101108

Syfte Syftet med detta arbete var att ur före detta tävlings-fäktares perspektiv undersöka orsakerna bakom de omfattande avhopp som sker i övergången mellan ungdoms- och seniorklass i svensk fäktning, samt vad föreningar och förbund kunnat göra för att motverka dessa avhopp. Studien syftar även till att undersöka vilka åtgärder föreningar och förbund kan göra för att främja återupptagandet av tävlande enligt före detta tävlings-fäktare. Vilka orsaker ser före detta värj-fäktande ungdomar till varför de slutade tävla? Vilka åtgärder kunde föreningar och förbund vidtagit enligt före detta värjfäktare för att förhindra deras avhopp ifrån tävlande som ungdomar? Vilka åtgärder kan enligt före detta värjfäktare föreningar och förbund vidta för att främja återupptagande av tävlande? Metod Studiens teoretiska utgångspunkt är motivationsteorin self-determination theory (SDT) och är genomförd med en kvalitativ ansats. Sex semistrukturerade intervjuer har genomförts med före detta fäktare. Intervjuerna har analyserats med tematisk innehållsanalys. Resultat Respondenterna upplevde ett kompetensbekräftande genom tävlandet samt en stark känsla av tillhörighet och när dessa faktorer försvann eller minskade i omfattning ledde det till avhopp. Vidare framkom att avhoppen hade kunnat förhindrats. Därutöver framkom att fäktarna kan ställa sig positiva till att återuppta tävlandet som motionärer ifall det skulle finnas en attraktiv breddverksamhet vad gäller både tävlingar och träningar. I ett återupptagande av tävlandet hade det sociala sammanhanget varit högt prioriterat men också möjligheten att få mäta sig mot fäktare på liknande nivå som de själva i anpassade tävlingsformer. Slutsats Det fanns ett starkt samband mellan avhoppen och att de psykologiska behoven upphörde att uppfyllas av deltagande i sporten. Svensk fäktning kunde under ungdomsåren starkt uppfylla behoven kopplade till att känna samhörighet och kompetens och även i viss mån autonomi men misslyckades med att tillgodogöra de grundläggande psykologiska behoven när fäktarna blev äldre. Vidare visar detta vikten av att föreningar och förbund arbetar aktivt med att tillgodose de grundläggande psykologiska behoven för motivation ifall avhoppen ska minskas och för att främja till återupptagandet av tävlande. / Aim The aim of this study was to investigate, from the perspective of former competitive fencers, the reasons behind the high level of drop outs that occur in the transition between youth and senior levels in Sweden, as well as what clubs and federations could have done to counteract these drop outs. The study also aimed to investigate what measures clubs and federations can take to promote the resumption of competing according to former competitive fencers. - What reasons do former épée fencing youths give as why they stopped competing? - According to former épée fencers, what measures could clubs and federations have taken to prevent youth drop out? - According to former épée fencers, what measures can clubs and federations take to promote the resumption of competing? Method The study's theoretical framework was the self-determination theory (SDT) and the research body was qualitative. Six semi-structured interviews have been conducted with former fencers. The interviews have been analyzed using thematic content analysis. Results The results showed that the former fencers had experienced a confirmation of competence through competitions, as well as a strong sense of belonging to their teammates and friends in the sport. When these factors disappeared or decreased, it led to drop outs. It also emerged that these drop outs could have been prevented. In addition, it emerged that the fencers are positive about resuming competition recreationally if there is an wide range of activities in terms of both competitions and training targeted at recreational fencers. For the resumption of competing, social context has been identified as a high priority. Another high priority is the opportunity to compete against fencers of a similar level to themselves in adapted forms of competition. Conclusions There was a strong correlation between the drop out of youth fencers and their psychological needs not being fulfilled in the sport. During childhood of the respondents, participation in fencing strongly fulfilled the need for a sense of belonging and feeling of competence, and to a certain extent autonomy. Fencing in Sweden however failed to provide this as the fencers got older. Furthermore, if drop outs are to be reduced and the competing is to be resumed, the study demonstrates the importance of clubs and confederations working actively to meet the psychological needs of the athletes.

In this thesis, we develop some inferential results for one-shot device testing data analysis. These extend and generalize existing methods in the literature. First, a competing-risk model is introduced for one-shot testing data under accelerated life-tests. One-shot devices are products which will be destroyed immediately after use. Therefore, we can observe only a binary status as data, success or failure, of such products instead of its lifetime. Many one-shot devices contain multiple components and failure of any one of them will lead to the failure of the device. Failed devices are inspected to identify the specific cause of failure. Since the exact lifetime is not observed, EM algorithm becomes a natural tool to obtain the maximum likelihood estimates of the model parameters. Here, we develop the EM algorithm for competing exponential and Weibull cases. Second, a semi-parametric approach is developed for simple one-shot device testing data. Semi-parametric estimation is a model that consists of parametric and non-parametric components. For this purpose, we only assume the hazards at different stress levels are proportional to each other, but no distributional assumption is made on the lifetimes. This provides a greater flexibility in model fitting and enables us to examine the relationship between the reliability of devices and the stress factors. Third, Bayesian inference is developed for one-shot device testing data under exponential distribution and Weibull distribution with non-constant shape parameters for competing risks. Bayesian framework provides statistical inference from another perspective. It assumes the model parameters to be random and then improves the inference by incorporating expert's experience as prior information. This method is shown to be very useful if we have limited failure observation wherein the maximum likelihood estimator may not exist. The thesis proceeds as follows. In Chapter 2, we assume the one-shot devices to have two components with lifetimes having exponential distributions with multiple stress factors. We then develop an EM algorithm for developing likelihood inference for the model parameters as well as some useful reliability characteristics. In Chapter 3, we generalize to the situation when lifetimes follow a Weibull distribution with non-constant shape parameters. In Chapter 4, we propose a semi-parametric model for simple one-shot device test data based on proportional hazards model and develop associated inferential results. In Chapter 5, we consider the competing risk model with exponential lifetimes and develop inference by adopting the Bayesian approach. In Chapter 6, we generalize these results on Bayesian inference to the situation when the lifetimes have a Weibull distribution. Finally, we provide some concluding remarks and indicate some future research directions in Chapter 7. / Thesis / Doctor of Philosophy (PhD)

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