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11	The contribution of environmental history to the development of a model to aid watershed management a comparative study of the Big Darby Creek and Deer Creek Watersheds in Ohio / Dameron-Hager, Irene F., January 2004 (has links) Thesis (Ph. D.)--Ohio State University, 2004. / Title from first page of PDF file. Document formatted into pages; contains xiii, 253 p.; also includes graphics (some col.). Includes abstract and vita. Advisor: Earl F. Epstein, Dept. of Natural Resources. Includes bibliographical references (p. 228-238).
12	John Nelson Darby his contributions to contemporary theological higher education / Sutherland, Winston Terrance. Lumsden, D. Barry, January 2007 (has links) Thesis (Ph. D.)--University of North Texas, May, 2007. / Title from title page display. Includes bibliographical references.
13	Inhibition of Phorbol Ester-Stimulated Arachidonic Acid Release by Alkylglycerols Robinson, Mitchell, Burdine, Robin, Warne, Thomas R. 09 February 1995 (has links) Although synthetic analogs of alkylglycerol (AG), such as dodecylglycerol, possess potent biological activities, their mechanism of action has not been determined. We recently detected substantial amounts of AG in unstimulated MDCK cells (Warne, T.R. and Robinson, M. (1991) Anal. Biochem. 198, 302-307) raising the possibility mediator. In this study, we examined the effects of synthetic AG on the release of arachidonic acid and arachidonate metabolites (AA) from Madin Darby canine kidney (MDCK) cells in response to 12-O-tetradecanoylphorbol-13-acetate (TPA) in order to characterize its effects on this signalling pathway. Treatment of MDCK with AG potently inhibited the release of AA during subsequent stimulation with TPA. Dodecylglycerol, the most effective of a series of alkylgycerols tested, was active at concentrations as low as 3 μM. The sn-1 and sn-3 forms of AG were found to be equally potent inhibitors. The effects of AG on AA release were not the result of arachidonic acid redistribution among cellular lipids and were independent of the phospholipid source of the released AA. AG did not inhibit the release of AA from MDCK cells when bradykinin was used as a stimulus, indicating selectivity for the effects produced by phorbol esters. These results show that AG can function as a potent and specific inhibitor of TPA-mediated AA release. The ability of AG to regulate this signalling pathway in intact MDCK cells, together with its natural occurrence, suggests a potential bioregulatory role for the endogenous compound as an inhibitor of protein kinase C. alkylglycerol arachidonic acid madin-darby canine kidney monoglyceride phorbol myristate acetate protein kinase C
14	Cultivating Collaborative Partnerships in Natural Resource Conservation: Lessons Learned from the Big Darby Melton, Tamara Lim 28 July 2003 (has links) No description available. Environmental Sciences Collaboration Natural Resource Conservation Big Darby Watershed Ohio Dispute Resolution Cooperation
15	The contribution of environmental history to the development of a model to aid watershed management: a comparative study of the Big Darby Creek and Deer Creek Watersheds in Ohio Dameron-Hager, Irene Frances 20 May 2004 (has links) No description available. environmental history natural resources watershed management hydrology Big Darby Creek Deer Creek
16	The effect of urbanization on the hydrologic regime of the Big Darby Creek watershed, Ohio Ahn, Gi-Choul 30 August 2007 (has links) No description available. Engineering, Civil Urbanization Big Darby Creek Watershed LULC hydrologic modeling HEC-HMS
17	John Nelson Darby: His Contributions to Contemporary Theological Higher Education Sutherland, Winston Terrance 05 1900 (has links) This study investigated the contributions of John Nelson Darby to selected institutions of contemporary theological higher education. A qualitative approach to the investigation was employed. Archival foraging occupied a greater part of the research data and yielded rich returns as evidenced in the literature review. Purposeful sampling was also utilized. The faculty and administration of three institutions, Moody Bible Institute, Dallas Theological Seminary, and Emmaus Bible College, were mailed questionnaires comprising 22 questions to ascertain their opinions of Darby's contributions to their institutions. Of the 22 questions, 21 were of a Likert type scale offering 5 options: Strongly agree, Agree, Not sure, Disagree, and Strongly disagree; and 1 open-ended question. A response rate of 45% (N=27) was achieved. All results were statistically significant at the p=.05 level utilizing chi-square goodness-of-fit tests. Theological higher education dispensationalism hermeneutics interpretation prophecy Darby, J. N. (John Nelson), 1800-1882. Moody Bible Institute. Dallas Theological Seminary. Emmaus Bible College (Dubuque, Iowa)
18	The O.C. Voss Site: reassessing what we know about the Fort Ancient occupation of the central Scioto drainage and its tributaries Brady-Rawlins, Kathleen L. 07 June 2007 (has links) No description available. magnetic survey fluxgate gradiometer geophysical survey remote sensing Fort Ancient Late Prehistoric Cole Complex Big Darby Creek Baum phase Baum series ceramics Fort Ancient mound construction
19	Entstehung und Entwicklung der „Elberfelder Bibel“ (Neues Testament) von der Erstübersetzung bis heute: eine Untersuchung des übersetzungsansatzes und eine kritische Würdigung / The origin and development of the "Elberfelder Bibel" (New Testament) from the first version to the present: an examination of the translation approach and a critical appraisal Riedel, Thomas 03 1900 (has links) Text in German with summaries in German and English / Includes bibliographical references (leaves 191-195) / Die Elberfelder Bibel prägt bis heute die deutsche Brüderbewegung und ist auch darüber vielen Christen bekannt. 1855 erschien erstmals das Neue Testament, 1871 die gesamte Bibel. Von 1960 bis 1984 wurde eine umfassende Revision durchgeführt. Ihre Sprache gilt als schwierig, gleichzeitig wird sie als sehr genaue Übersetzung wahrgenommen. Bis heute gibt es keine umfassende Forschungsarbeit über die Elberfelder Bibel, obwohl sie mehr als 160 nach ihrer Ersterscheinung immer noch gelesen und neu herausgegeben wird. Die vorliegende Arbeit möchte Ziele und Übersetzungsansatz der Erstübersetzung offen legen. Danach wird die praktische Umsetzung dieses Ansatzes anhand von drei ausgewählten Kapiteln des Neuen Testamentes untersucht. Dabei wird auch der Einfluss der Revision ab 1960 geprüft. Eine Einordnung in die aktuelle Übersetzungsdiskussion und Vorschläge für die Weiterentwicklung dieser Übersetzung runden die Arbeit ab. / The Elberfelder Bibel has had a big impact on the Brethren movement and beyond until today. In 1855, the New Testament was published for the first time, followed by the whole bible in 1871. From 1960 until 1984, a broad revision has been conducted. The Elberfeld Bibel is said to be linguistically difficult; at the same time it is considered as a very accurate translation. Until today, no comprehensive research paper has been written about this translation, which by now is more than 160 years old. This paper deals with the goals and the translation approach of the initial translation. Furthermore, the practical implementation of this approach is examined by means of three particular chapters of the New Testatment. In addition, the impact of revisions starting from 1960 is going to be explored. Its placement in the current discussion on translation and suggestions for further development of this translation will complete the paper. / New Testament / M.Th. (New Testament) Bibelübersetzung Brockhaus, Carl Darby, John Nelson Einheitsübersetzung Elberfelder Bibel Hypotaktischer Satzbau Lutherbibel Partizip Satzbau Syntax Textkritik TR Transparenz Übersetzungsansatz Von Poseck, Julius Anton Zielgruppenbibel Bible translation Brockhaus, Carl Darby, John Nelson Elberfelder Bibel Hypotactic syntax Lutherbibel Participle Syntax Textual criticism Textus Receptus Transparency Translation approach Von Poseck, Julius Anton Target group Bible 220.531 Bible. Elberfelder. 1855 -- Influence Bible. German -- Versions Brockhaus, Carl, 1822-1899 Brethren (Brethren churches) Darby, J. N. (John Nelson), 1800-1882 Poseck, J. A. von
20	Development of Sensitive In Vitro Assays to Assess the Ocular Toxicity Potential of Chemicals and Ophthalmic Products McCanna, David January 2009 (has links) The utilization of in vitro tests with a tiered testing strategy for detection of mild ocular irritants can reduce the use of animals for testing, provide mechanistic data on toxic effects, and reduce the uncertainty associated with dose selection for clinical trials. The first section of this thesis describes how in vitro methods can be used to improve the prediction of the toxicity of chemicals and ophthalmic products. The proper utilization of in vitro methods can accurately predict toxic threshold levels and reduce animal use in product development. Sections two, three and four describe the development of new sensitive in vitro methods for predicting ocular toxicity. Maintaining the barrier function of the cornea is critical for the prevention of the penetration of infections microorganisms and irritating chemicals into the eye. Chapter 2 describes the development of a method for assessing the effects of chemicals on tight junctions using a human corneal epithelial and canine kidney epithelial cell line. In Chapter 3 a method that uses a primary organ culture for assessing single instillation and multiple instillation toxic effects is described. The ScanTox system was shown to be an ideal system to monitor the toxic effects over time as multiple readings can be taken of treated bovine lenses using the nondestructive method of assessing for the lens optical quality. Confirmations of toxic effects were made with the utilization of the viability dye alamarBlue. Chapter 4 describes the development of sensitive in vitro assays for detecting ocular toxicity by measuring the effects of chemicals on the mitochondrial integrity of bovine cornea, bovine lens epithelium and corneal epithelial cells, using fluorescent dyes. The goal of this research was to develop an in vitro test battery that can be used to accurately predict the ocular toxicity of new chemicals and ophthalmic formulations. By comparing the toxicity seen in vivo animals and humans with the toxicity response in these new in vitro methods, it was demonstrated that these in vitro methods can be utilized in a tiered testing strategy in the development of new chemicals and ophthalmic formulations. in vitro Alternative Methods alamarBlue rhodamine tight junctions bovine lens viability toxicity mitochondria mitochondria integrity benzalkonium chloride sodium dodecyl sulphate sodium lauryl sulfate scanning electron microscopy Draize Draize maximal average scores zonula occludens cosmetic directive PETA humane society animal league ICCVAM ECVAM JaCVAM BCOP bovine cornea ocular irritants ocular irritation ocular toxicity human corneal epithelial cells vitro confocal confocal microscopy metabolic activity optical quality reactive oxygen species contact lens contact lens care solutions barrier function microbial keratitis mulitipurpose solutions tight junction cell damage claudin ZO-1 occludin MDCK Madin Madin-Darby canine kidney cells cornea human cornea human corneal epithelium epithelial cell line human corneal epithelial cell line sodium fluorescein sodium fluorescein permeability fluorescein permeability ocular surface cell monolayer Araki-Sasaki cell physiology risk assessment safety assessment ScanTox scanning laser lens epithelium corneal cells in vitro model ophthalmic formulations multiple instillation back vertex animal testing rabbit testing alternatives to animal testing cultured bovine lens toxicity of chemicals irritation irritants laser scanner organ culture delayed toxicity toxins hydrogen peroxide cornea toxicity cornea toxicity models prediction of human toxicity no observable adverse effect level lowest observable adverse effect level NOAEL LOAEL toxicity thresholds safety factors cornea uncertainty factors preservatives disinfectants ophthalmic products preclinical preclinical testing epithelial barrier drug penetration clinical confocal microscopy animal rights rabbit cornea human cornea human clinical effects toxic animal rights activist sensitive measures toxic effect toxicity threshold agar overlay agar diffusion agar overlay method agar diffusion method cytochrome cytochrome c apoptosis necrotic apoptotic necrosis caspase rhodamine 123 resazuran resorufin cell death cell viability metabolic dye microsomal microsomal enzymes cytotoxicity cytotoxic cytotoxic effect MTT XTT WST-1 plasma membrane mitochondrial mitochondrial morphology ocular toxicity potential ocular toxicity human corneal epithelial cell line confocal analysis corneal epithelium cell fluorescence alamarBlue assay rhodamine dye animal welfare toxic injury degraded mitochondria epithelial monolayer disinfectants membrane integrity eye toxicity eye viability dye toxicity in humans human toxicity effects on the mitochondria mitochondrial toxicity in vitro battery in vitro test battery ophthalmic eye drop direct contact product safety cytotoxicity potential molecular molecular biology refine reduce replace sensitivity and relevance sensitivity relevance rabbit ocular irritation test product development cytotoxicity models cytotoxicity alternative methods replacements for animal testing three r's beagle tiered testing tiered testing strategy replacements animal testing mechanistic toxicity cornea mitochondria dose response threshold Vision Science and Biology

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