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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
181

Essays on travel mode choice modeling : a discrete choice approach of the interactions between economic and behavioral theories / Essais sur la modélisation du choix modal : une approche par les choix discrets des interactions entre théories économiques et comportementales

Bouscasse, Hélène 09 November 2017 (has links)
Cette thèse a pour objectif d’incorporer des éléments de théories de psychologie et d’économie comportementale dans des modèles de choix discret afin d’améliorer la compréhension du choix modal réalisé à l’échelle régionale. Les estimations se basent sur une enquête de type choice experiment présentée en première partie. Une deuxième partie s’intéresse à l’incorporation de variables latentes pour expliquer le choix modal. Après une revue de littérature sur les modèles de choix hybrides, c’est-à-dire des modèles combinant modèle d’équations structurelles et modèle de choix discret, un tel modèle est estimé pour montrer comment l’hétérogénéité d’outputs économiques (ici, la valeur du temps) peut être expliquée à l’aide de variables latentes (ici, le confort perçu dans les transports en commun) et de variables observables (ici, la garantie d’une place assise). La simulation de scénarios montre cependant que le gain économique (diminution de la valeur du temps) est plus élevé lorsque les politiques agissent sur des dimensions palpables que sur des dimensions latentes. S’appuyant sur un modèle de médiation, l’estimation d’un modèle d’équations structurelles montre par ailleurs que l’effet de la conscience environnementale sur les habitudes de choix modal est partiellement médié par l’utilité indirecte retirée de l’usage des transports en commun. Une troisième partie s’intéresse à deux formalisations de l’utilité issues de l’économie comportementale : 1) l’utilité dépendante au rang en situation de risque et 2) l’utilité dépendante à la référence. Dans un premier temps, un modèle d’utilité dépendante au rang est inséré dans des modèles de choix discret et, en particulier, un modèle à classes latentes, afin d’analyser l’hétérogénéité intra- et inter-individuelle lorsque le temps de déplacement n’est pas fiable. La probabilité de survenue d’un retard est sur-évaluée pour les déplacements en train et sous-évaluée pour les déplacements en voiture, en particulier pour les automobilistes, les usagers du train prenant d’avantage en compte l’espérance du temps de déplacement. Dans les modèles prenant en compte l’aversion au risque, les fonctions d’utilité sont convexes, ce qui implique une décroissance,de la valeur du temps. Dans un deuxième temps, une nouvelle famille de modèles de choix discret généralisant le modèle logit multinomial, les modèles de référence, est estimée. Sur mes données, ces modèles permettent une meilleure sélection des variables explicatives que le logit multinomial et l’estimation d’outputs économiques plus robustes, notamment en cas de forte hétérogénéité inobservée. La traduction économique des modèles de référence montre que les meilleurs modèles empiriques sont également les plus compatibles avec le modèle de dépendance à la référence de Tversky et Kahneman. / The objective of this thesis is to incorporate aspects of psychology and behavioral economics theories in discrete choice models to promote a better understanding of mode choice at regional level. Part II examines the inclusion of latent variables to explain mode choice. A literature review of integrated choice and latent variable models – that is, models combining a structural equation model and a discrete choice model – is followed by the estimation of an integrated choice and latent variable model to show how the heterogeneity of economic outputs (here, value of time) can be explained with latent variables (here, perceived comfort in public transport) and observable variables (here, the guarantee of a seat). The simulation of scenarios shows, however, that the economic gain (decrease in value of time) is higher when policies address tangible factors than when they address latent factors. On the basis of a mediation model, the estimation of a structural equation model furthermore implies that the influence of environmental concern on mode choice habits is partially mediated by the indirect utility derived frompublic transport use. Part III examines two utility formulations taken from behavioral economics: 1) rankdependent utility to model risky choices, and 2) reference-dependent utility. Firstly, a rank-dependent utility model is included in discrete choice models and, in particular, a latent-class model, in order to analyze intra- and inter-individual heterogeneity when the travel time is subject to variability. The results show that the probability of a delay is over-estimated for train travel and under-estimated for car travel, especially for car users, as train users are more likely to take into account the expected travel time. In the models that account for risk aversion, the utility functions are convex, which implies a decrease in value of time. Secondly, a new family of discrete choice models generalizing the multinomial logit model, the reference models, is estimated. On my data, these models allow for a better selection of explanatory variables than the multinomial logit model and a more robust estimation of economic outputs, particularly in cases of high unobserved heterogeneity. The economic formulation of reference models shows thatthe best empirical models are also more compatible with Tversky et Kahneman’s reference-dependent model.
182

Escolhas baseadas em múltiplos objetivos: a evolução do homo economicus ao homo aptabilis / Multiple goals-based choice: the evolution from homo economicus to homo aptabilis

Pilli, Luís Eduardo 12 September 2017 (has links)
Escolhas são meios para que indivíduos e consumidores atinjam seus objetivos. São objeto de estudo em diversas disciplinas e eu me apoiei em três delas para desenvolver estas tese. Modelos normativos da economia que definem o homo economicus, modelos descritivos das teorias de decisão comportamental que forjam o homo aptabilis, capaz de fazer escolhas que permitam o atingimento de seus objetivos. E modelos econométricos de escolha discreta, que permitem o uso e teste de teorias comportamentais usando métodos flexíveis e realistas. O argumento central desta tese é que modelos econométricos devem considerar a heterogeneidade do comportamento individual em todo o processo de escolha, incluindo objetivos do consumidor, estratégias de decisão, formação de conjuntos de escolha subjetivos, além de preferência. O não reconhecimento desta complexidade nos processos de escolha produz modelos falsos, capturando a heterogeneidade no nível das preferências e induzindo organizações a tomarem decisões equivocadas. Para desenvolver este argumento, esta tese se organiza em três seções. Na primeira eu faço uma revisão da literatura com foco nos diversos níveis do processo de escolha onde a heterogeneidade se manifesta e relaciono os modelos de escolha com as teorias comportamentais de decisão. Na segunda seção é desenvolvido um estudo sobre os vieses provocados quando a heterogeneidade na formação de conjuntos subjetivos de escolha não é levada em consideração. Através de experimentos de Monte Carlo fica comprovado que os parâmetros de modelos econométricos de escolha são generalizadamente viesados, levando à estimadas equivocadas de probabilidades de escolhas das marcas e das elasticidades das probabilidades de escolha. Esses resultados são usados para motivar uma abordagem de teoria dos jogos que resulta em equilíbrio distante do ideal, do ponto de vista de resultados das empresas. Finalmente na terceira seção, é desenvolvido um modelo de escolha discreta baseado em múltiplos meta-objetivos e em diferentes processos de escolha individual. Mais um experimento de Monte Carlo comprova que o modelo é capaz de recuperar o parâmetros do processo gerador de dados. O modelo além de reconhecer a existência de diversos meta-objetivos que ativam diferentes regras comportamentais, também permite estudar a adaptação do processo de escolha individual em função de variáveis de contexto, de situação e individuais. O modelo articula modelos econométricos com teorias comportamentais de decisão e oferece suporte para a compreensão do homo aptabilis / Choices are the means for individuals and consumers to attain their goals. They are the objects of study for several disciplines and I relied on three of them to develop this thesis. Normative models from economicsdefining the homo economicus, descriptive models from behavioral decision theories that forge the homo aptabilis, able to adaptively pursue multiple goals through choices. And discrete-choice econometric models that allow the use and testing of behavioral theories using flexible and realistic methods. The central argument of this thesis is that econometric models should consider the heterogeneity of individual behavior throughout the choice process, including consumer goals, decision strategies, choice set formation, and preferences. Failure to recognize this complexity in the choice process produces false models, capturing process heterogeneity at the level of preferences, and inducing organizations to make the wrong decisions. To develop this argument, this thesis is organized into three sections. In the first one, I review the literature focusing on the different levels of the choice process where the heterogeneity manifests itself and I relate the choice models to the behavioral decision theories. In the second section, a study is developed on the biases caused when heterogeneity in the choice set formation is not accounted for. Through Monte Carlo experiments it has been proven that the parameters of econometric choice models are generally biased, leading to misleading estimates of brands choice probabilities and of attribute\'schoice elasticities. These results are used to motivate a game theoretical approach that results in far-fetched equilibrium from the point of view of business results. Finally, in the third section, a discrete choice model based on multiple meta-goals and on different individual choice processes is developed. One more Monte Carlo experiment proves that the model is capable of retrieving the parameters of the data-generating process. The model, besides recognizing the existence of several meta-objectives that activate different behavioral rules, also allows studying the adaptation of the consumer choice process as a response to context, situation, and individual variables. The model articulates econometric models with behavioral decision theories and supports the understanding of the homo aptabilis.
183

Demanda potencial para um sistema de compartilhamento de bicicletas pedelecs: o caso de um campus universitário / Potential demand for a pedelec sharing system: the case of a university campus

Cadurin, Leonardo Dal Picolo 12 May 2016 (has links)
Este trabalho teve como objetivo analisar a demanda potencial para um sistema de compartilhamento de bicicletas pedelecs no campus da USP de São Carlos, com foco nos deslocamentos de estudantes entre as duas áreas do campus. Para tanto, foi elaborado um conjunto de procedimentos, que constituem duas etapas: caracterização do público-alvo e análise da demanda potencial pelas bicicletas pedelecs compartilhadas. Na primeira etapa foi aplicado um questionário, elaborado com a técnica de preferência declarada, para verificar as preferências dos usuários em relação às pedelecs compartilhadas e ao ônibus operado pela USP. Os resultados desta consulta, que envolveu variáveis de condições meteorológicas, situação de ciclovias/ciclofaixas entre as áreas do campus e lotação do ponto de ônibus USP, foram posteriormente utilizados para calibrar um modelo logit e treinar uma Rede Neural Artificial (RNA). Na segunda etapa foi elaborada uma planilha eletrônica com os dados obtidos na coleta, a fim de analisar as probabilidades de escolha da pedelec (ao invés do ônibus USP). Nesta planilha também foram utilizados dados do histórico meteorológico de São Carlos no período entre 2011 e 2015. Alguns dos resultados obtidos são destacados na sequência. A probabilidade de escolha das pedelecs é, em média, três vezes maior quando existem ciclovias/ciclofaixas (em relação à ausência da referida infraestrutura cicloviária). A ocupação do ponto de ônibus USP também é impactante, pois as probabilidades de uso da bicicleta pedelec praticamente dobram quando o ponto está cheio. No caso da meteorologia, foi constatado que as maiores probabilidades ocorrem no Outono e no Inverno, ou seja, nas épocas em que se concentram os dias mais secos e com menores temperaturas. Para o período letivo de 2011 a 2015, considerando a situação atual (isto é, sem ciclovias/ciclofaixas entre as áreas), os valores de probabilidade de uso da pedelec correspondem a 9% com o ponto vazio e 19% com o ponto cheio. Se houvesse ciclovias/ciclofaixas, a probabilidade seria de até 54%. Desse modo, a estratégia de análise desenvolvida conceitualmente, bem como implantada em planilha eletrônica, se constitui em importante ferramenta de auxílio para a condução da política de transportes que a Prefeitura do campus irá adotar para os anos futuros. Além disso, evidencia uma possível demanda potencial para um sistema com pedelecs compartilhadas. / The objective of this study was to analyze the potential demand for a pedelec sharing system at the São Carlos campus of the University of São Paulo (USP), aiming at the displacements of students between the two campus Areas. The set of procedures developed to reach the objective has involved two steps: characterization of the target audience and analysis of the potential demand for shared pedelecs. The first step was accomplished with a questionnaire designed with a stated preference approach for identifying users\' preferences regarding shared pedelecs and the bus system operated by the university. The survey results, which involved variables of weather conditions, existence of bike paths/bike lanes between the campus Areas, and occupancy rates at the USP bus stop, were subsequently used to calibrate a logit model and to develop an Artificial Neural Network (ANN). The survey data were also used in the second step of the process, in which an electronic spreadsheet was created to analyze the probabilities of choosing the pedelec alternative (instead of the bus route operated by university). The spreadsheet was also fed with meteorological data of São Carlos in the period between 2011 and 2015. Some of the obtained outcomes are highlighted in the sequence. The probability of a pedelec being chosen is almost three times higher if bike paths/bike lanes do exist than if they do not exist. The occupancy rates of the bus stop are also particularly relevant. The probability of someone choosing a pedelec nearly doubles when the bus stop is crowded. Regarding the weather conditions, the highest probabilities are observed in the Fall and Winter seasons, i. e. in the driest and coldest days. For the entire academic period comprised between 2011 and 2015, the probabilities range from 9% (empty bus stop) to 19% (full bus stop), considering the current situation (i. e. no cycleways connect the two campus Areas). In the presence of this cycling infrastructure, however, the probability goes up to 54%. Thus, the strategy of analysis conceptually developed, and made available through an electronic spreadsheet, may be an important support tool for the implementation of transport policies by the campus administration. In addition, it highlights a likely potential demand for a system of shared pedelecs.
184

Análise de fatores que influem no uso da bicicleta para fins de planejamento cicloviário / Analysis of factors that influence the use of the bicycle for bicycle facility planning

Sousa, Pablo Brilhante de 01 October 2012 (has links)
A meta deste trabalho é propor um procedimento para identificar os fatores que influem no uso de bicicletas e apresentar a forma como estes fatores podem ser usados para avaliar e planejar a implantação de ciclovias e/ou ciclofaixas em uma área urbana. Para tanto, foi elaborado um método que consistiu, inicialmente, de obtenção de dados socioeconômicos e de viagens urbanas de locais dotados de ciclovias e/ou ciclofaixas disponíveis para a população e de contagens volumétricas de ciclistas antes e depois da implantação da infraestrutura cicloviária. Em seguida, foi realizado um experimento que consistiu de caracterização dos dados socioeconômicos, de viagens urbanas e de infraestrutura cicloviária, a partir das quais foi estimado um modelo de escolha discreta que possibilitou a identificação de fatores que influem no uso da bicicleta na RMBS e que serviu para quantificar a demanda cicloviária em pontos preestabelecidos. Através da construção de cenários antes e depois da implantação da infraestrutura cicloviária e da comparação entre contagens volumétricas de ciclistas da RMBS, realizadas em vários pontos da rede viária, e a estimação da demanda cicloviária nestes pontos usando o modelo de escolha discreta, concluiu-se que o modelo permite identificar e quantificar os fatores e a forma como eles interferem na demanda cicloviária e que, portanto, os resultados podem ser usados para avaliar e direcionar as intervenções no sistema de transportes com o intuito de facilitar o uso do modo bicicleta. / The main aim of this work is to propose a procedure to identify and quantify the factors that influence the use of bicycles and to present how these factors can be used to evaluate and plan the deployment of segregated bike lanes and/or cyclelanes in an urban area. For attaining the aims, a method was developed and consisted firstly in to obtain socioeconomic data and urban travel data in places equipped with segregated bike lanes and/or cyclelanes available to the population and with counts of cyclists before and after the implementation of cycling infrastructure. Then, an experiment was conducted which consisted of characterization of the socioeconomic data and urban trips and cycling infrastructure from which a discrete choice model was estimated that allowed the identification of factors that influence the use of bicycles in a RMBS and was used to quantify the cycling demand on predetermined points. By the construction of scenarios before and after the implementation of cycling infrastructure and the comparison between counts of cyclists in a RMBS and the estimation of cycling demand in these points using discrete choice model, the main conclusion of this work is that the model allow us to identify and quantify the factors and how they interfere in a cycling demand. Therefore the results can be used to evaluate and direct interventions in the transport system in order to facilitate use of bicycle mode.
185

Space disaggregation in models of route and mode choice : method and application to the Paris area / D?sagr?gation de l?espace dans les mod?les de choix d?itin?raire et de mode : m?thode et application ? la r?gion Ile-de-France

Samadzad, Mahdi 18 January 2013 (has links)
La repr?sentation spatiale de l?aire de mod?lisation dans les mod?les de la demande de transports a peu chang? au cours des derni?res d?cennies. A cet ?gard, l??tat-de l?art repose encore largement sur le syst?me de centro?de-connecteur qui est utilis?e dans les mod?les classiques. Elle est une approche agr?g?e qui ignore la variabilit? physique li?e ? la dispersion des lieux d?sagr?g?s de r?sidence et d?activit? dans l?espace local. En cons?quence, le pouvoir explicatif des mod?les quant aux comportements de choix d?itin?raire et de mode demeure limit? ? l??chelle locale : Par exemple, la localisation d?sagr?g?e influence sur le choix entre une autoroute dont l??changeur est ?loign?, et un autre itin?raire non-autoroutier. Egalement, le rabattement terminal influence sur le partage modal auto vs. transports en commun. Nous pr?sentons une approche d?sagr?g?e pour la repr?sentation spatiale. Dans un d?coupage zonal, l?espace ? l?int?rieur d?une zone est repr?sent? de mani?re d?sagr?g?e stochastique. Pour chaque zone, les points d?ancrage sont d?finis relative aux n?uds du r?seau qui peuvent ?tre utilis?s pour acc?der au r?seau. Un itin?raire entre une paire de zones est ensuite consid?r? comme une chaine, compos?e de deux trajets terminaux, correspondants aux sections intrazonales de l?itin?raire, et d?un trajet principal correspondant ? la section entre deux points d?ancrage. En cons?quence, le mod?le de choix d?itin?raire est transform? ? un mod?le de choix conjoint d?une paire de point d?ancrage. Le vecteur des temps al?atoires terminaux est Normal Multidimensionnel donnant lieu ? un mod?le Probit de choix conjoint de points d?ancrage.Pour ?tendre au cadre multimodal, un mode collectif composite est d?fini comme une chaine compos?e des trois trajets modaux d?acc?s, principal, et de sortie, et les stations sont consid?r?es comme les points d?ancrage, connectant les trajets de rabattement au trajet principal. Un mod?le Logit Multinomial de choix de mode est estim? ? partir de l?Enqu?te Globale de Transport de 2001 pour le mode auto et le faisceau des modes collectifs composites, et est combin? avec les deux mod?les Probit correspondants au choix des stations / Spatial representation of modeling area in travel demand models has changed little over the course of last several decades. In this regard, the state-of-the-art still widely relies on the same centroid-connector system that has been used in classic models. In this approach continuum bidimensional space is lumped on centroids. It is an aggregate approach which ignores the physical variability linked to the scatteredness of disaggregate residence- and activity-places over the local space. Consequently the modeling performance in explaining route and mode choice behavior degrades at local scales: In route choice, disaggregate location influences the propensity between a distant interchange to a highway, or a nearby road. In mode choice, feeder service to public transportations influences the auto vs. transit modal share. We propose a disaggregate approach for spatial representation. Based on a zoning system, a stochastic disaggregate representation is used to characterize the space within a traffic analysis zone. For each zone, anchor-points are defined as the network nodes that are used for accessing to the network from within the local space. An itinerary between a pair of zones is then considered as a chain of legs composed of two terminal legs, corresponding to the intrazonal route sections, and one main leg between two anchor points. The route choice problem is transformed to a joint choice of a pair of anchor points. The vector of random terminal travel times is Multivariate Normal resulting in a Multinomial Probit model of choice of a pair of anchor points. To extend to the multimodal context, a transit composite mode is defined as a chain of access, main, and egress modal legs, and transit platforms are considered as anchor points connecting the feeder legs to the main line-haul leg. A Multinomial Logit mode choice model is estimated based on the 2001 Paris Household Travel Survey for the auto mode and the composite transit modes. It is joined with the two Multinomial Probit models corresponding to the choice of anchor points. The result is a joint model of mode and station choice with a disaggregate representation of the local space
186

Rôle de la tarification de l'activité des établissements de santé dans l'accès des patients aux traitements anticancéreux oraux : exemple du cancer du sein métastatique HER2+ / Role of the tariff of activity health facilities in patient access the oral cancer treatment : example of breast cancer metastatic HER2 +

Benjamin, Laure 30 November 2012 (has links)
Depuis le début des années 2000, les traitements anticancéreux oraux (TAO) sont en développement croissant, notamment dans le cancer du sein. Ils permettent aux patients la prise de comprimés par voie orale à domicile améliorant la qualité de vie. On estime que 10 à 34% des tumeurs du sein sur-expriment la protéine HER2 (HER2+) qui augmente le risque de métastases. Deux thérapies ciblées anti-HER2 sont actuellement disponibles : le trastuzumab, anticorps monoclonal administré par voie intraveineuse et le lapatinib, inhibiteur de tyrosine kinase administré par voie orale. D’après les recommandations de l’Agence Nationale d’Accréditation et d’Evaluation en Santé (ANAES, 2003), les TAO devraient être privilégiées par rapport aux formes intraveineuses prises à l’hôpital lorsque leur efficacité est équivalente. Dans la pratique courante des oncologues, les TAO semblent néanmoins sous-utilisées dans certains cas. En plus des freins médicaux connus (adhésion thérapeutique, gestion des effets indésirables), les TAO induisent une consommation de ressources hopitalières supplémentaires qui n’est pas valorisée dans le modèle de tarification à l’activité (T2A) des établissements hospitaliers, lequel repose sur la nature et la quantité d’activité médicale réalisée. Nous supposons que le modèle de T2A représente un frein économique à l’utilisation des TAO entrainant une disparité d’accès entre les traitements anticancéreux oraux et intraveineux. L’objectif de ce travail de thèse était donc de déterminer le rôle de la T2A dans l’accès des patients aux TAO au moyen d’une évaluation médico- économique de l’impact économique et organisationnel des TAO sur le système de soins. Une revue de littérature a permis de mettre en évidence le rôle du mode de financement des soins sur l’accès aux TAO en France et aux Etats-Unis. L’analyse des bases de données nationales hospitalières du Programme Médicalisé des Systèmes d’Information (PMSI) a permis de quantifier l’enjeu économique de la chimiothérapie pour les établissements de soins et qui représente la deuxième activité des hôpitaux en volume après l’hémodialyse. Le bénéfice lié aux séances de chimiothérapie a ainsi été estimé à 108 millions d’Euros en 2010 pour l’ensemble des établissements publics et privés en France. L’analyse a également permis de simuler le transfert d’allocation de ressources de l’hôpital vers les soins de ville induit par la substitution des séances de chimiothérapie par l’utilisation des TAO. Un modèle comparant le coût du traitement intraveineux (trastuzumab) aux TAO (lapatinib et capécitabine) dans le cancer du sein métastatique HER2+ a confirmé des coûts moindres pour les TAO (17 165€ versus 36 077€ par an et par patient) liés à une économie sur les transports médicalisés mais surtout sur les consommations hospitalières et ce, malgré un coût d’acquisition plus élevé des TAO. Malgré cet impact budgétaire négatif pour les hôpitaux, une étude de préférences (Méthode des Choix Discrets) conduite auprès d’un échantillon de 203 médecins hospitaliers et libéraux a montré que l’efficacité d’un traitement anticancéreux restait le déterminant principal de la décision thérapeutique (β=2,214, p<0,0001). L’étude a toutefois révélé que, aux stades avancés du cancer, la voie d’administration et son coût étaient également associés au choix du traitement (β=0,612, p=0,035 ;β=0,506, p<0,0001). Les résultats montrent donc que le modèle de financement de l’activité hospitalière influence le choix des modalités de traitement même si les critères d’ordre médicaux et environnementaux du patient demeurent des déterminants essentiels dans le choix du recours aux TAO (profil clinique du patient, adhésion thérapeutique, préférences du patient, environnement familial et socio-économique, conditions d’accès à l’offre de soins) / Since the early 2000’s, oral anticancer drugs (OADs) are increasingly available especially for the treatment of breast cancer. This route of chemotherapy administration allows patients to take oral tablets at home improving their quality-of-life. We estimate that 10 to 34% of breast tumors over-express the HER2 protein (HER2+) that increases the risk of developing metastasis. Two anti-HER2 targeted therapies are currently available: trastuzumab, a monoclonal antibody administered intravenously and lapatinib, a tyrosine kinase inhibitor administered orally. According to the recommendations of the National Agency for Accreditation and Evaluation in Health (ANAES, 2003), OADs should be administered when their efficacy is equivalent to the one of intravenous forms taken at hospital. In the current practice of oncologists, OADs seem to be underused in some cases. The medical brakes to the use of OADs (i.e. adherence, management of side effects) are well known. Nonetheless, OADs induce additional hospital healthcare resources which are not taken into account in the hospital payment system that is based on the nature and the quantity of medical activities performed (i.e. per-case payment system (PPS)). We assume that the current model of PPS represents an economic barrier to the use of OADs and which induces a disparity of access between oral and intravenous cancer treatments. The objective of this thesis was to determine the role of the PPS on the patient access to OADs based on a medico-economic evaluation of the economical and organizational impacts of OADs on the health care system. A literature review has highlighted the role of the funding of care on the access to OADs in the French and US healthcare systems. From an analysis of the national hospital database (PMSI database), we have quantified the economic implications of chemotherapy administration that is the second hospital activity in volume after hemodialysis. Earnings associated with chemotherapy sessions have been estimated at 108 million Euros in 2010 for all private and public institutions in France. This analysis also allowed us to simulate the transfer of resources allocation from hospital to community setting induced by the substitution of chemotherapy sessions by the use of OADs. A model comparing the cost of intravenous anticancer drug (trastuzumab) to OADs (lapatinib and capecitabine) in the treatment of HER2+ metastatic breast cancer confirmed the lower costs for OADs (€ 17,165 versus € 36,077 per year per patient). The higher acquisition cost of OADs was offset by the cost savings in terms of medical transportation and hospital resources. Despite this negative budget impact for hospitals, a preference study (Discrete Choice Experiment) conducted among 203 physicians showed that the efficacy of cancer treatment remained the main determinant of the therapeutic decision (β=2.214, p<0.0001). The study has also revealed that, in the advanced stages of cancer, the route of administration and its associated cost was also associated with the treatment choice (β=0.612, p= 0.035; =β0.506, p<0.0001). Overall, the results show that the hospital payment system influences the choice of treatment modalities. Nonetheless, medical criterions related to the patient remain essential in the choice of using OADs (clinical profile of the patient, adherence, patient preferences, familial and socio-economic environment, and conditions of access to health care)
187

Determinants and transmission of monetary policy in China / Déterminants et transmission de la politique monétaire en Chine

Lunven, Sandrine 17 December 2015 (has links)
L’objectif est d’analyser les déterminants et les mécanismes de transmission de la politique monétaire en Chine au cours des deux décennies passées. Elle contribue à la littérature par le biais de deux nouvelles mesures de la politique monétaire en Chine, l'une combinant les instruments utilisés par la banque centrale et l'autre basée sur les discours de la banque centrale sur la politique monétaire. Ces deux approches permettent de prendre en compte le comportement complexe et adaptatif de la banque centrale. Ces mesures permettent de mettre en évidence des changements substantiels dans le style de la politique à partir de 2002, plus graduelle et agressive envers l’inflation, en lien avec le début du mandat du gouverneur Xiaochuan, le processus de libéralisation des taux d’intérêt et l’ouverture commerciale et financière de la Chine. De plus, l’estimation d’un modèle à choix discret révèle une politique monétaire caractérisée par une politique accommodante sur l’inflation avant 2002 et un ciblage implicite de l’inflation à partir de 2002, similaire à celles du G3 pré- et post-1979. Enfin, cette thèse analyse les facteurs expliquant la déformation de la courbe des taux obligataires en Chine au cours de la dernière décennie. Alors que le contrôle des taux d’intérêt peut entraver l’usage de la courbe de taux comme référence pour évaluer les actifs risqués, celle-ci évolue bien en lien avec les autres instruments, la situation macroéconomique en Chine et de plus en plus aux communications de la banque centrale. Enfin, nos analyses révèlent l’influence de la politique monétaire américaine sur celle de la Chine et sur l’évolution de la courbe de taux sur la décennie passée. / The objective of this thesis is to enhance the understanding of the determinants and the transmission mechanisms of monetary policy in China over the last two decades. It contributes to the literature providing two new composite measures of monetary policy in China based on alternative approaches, one combining the large range of monetary policy instruments and the other based on central bank speeches. Both prove to be essential to take into account the complex and adaptive behavior of the People’s Bank of China (PBC). Our instrument-based monetary policy index emphasizes substantial changes in policy style towards smoother but more hawkish policy moves from 2002 onwards, consistent with the start of the mandate of Governor Zhou Xiaochuan, the interest rate liberalization process and the increasing trade and financial opening. Moreover, the estimation of a discrete-choice model implies a conduct of monetary policy characterized by an inflation-accommodating policy before 2002 and an implicit inflation targeting from 2002 onwards, which respectively resembles that of pre-1979 and post-1979 policy of the G3. Our thesis examines the deformation of the bond yield curve over the last decade to evaluate monetary policy transmission mechanisms. While regulated interest rates can hamper the use of the yield curve as benchmark for pricing risk, the latter moves in line with the other instruments, the macroeconomic situation, and increasingly to central bank communication, a crucial step toward a market oriented system. Finally, US monetary policy significantly affects monetary policy determinants and transmission mechanisms in China, particularly from its WTO accession in 2001.
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Análise de fatores que influem no uso da bicicleta para fins de planejamento cicloviário / Analysis of factors that influence the use of the bicycle for bicycle facility planning

Pablo Brilhante de Sousa 01 October 2012 (has links)
A meta deste trabalho é propor um procedimento para identificar os fatores que influem no uso de bicicletas e apresentar a forma como estes fatores podem ser usados para avaliar e planejar a implantação de ciclovias e/ou ciclofaixas em uma área urbana. Para tanto, foi elaborado um método que consistiu, inicialmente, de obtenção de dados socioeconômicos e de viagens urbanas de locais dotados de ciclovias e/ou ciclofaixas disponíveis para a população e de contagens volumétricas de ciclistas antes e depois da implantação da infraestrutura cicloviária. Em seguida, foi realizado um experimento que consistiu de caracterização dos dados socioeconômicos, de viagens urbanas e de infraestrutura cicloviária, a partir das quais foi estimado um modelo de escolha discreta que possibilitou a identificação de fatores que influem no uso da bicicleta na RMBS e que serviu para quantificar a demanda cicloviária em pontos preestabelecidos. Através da construção de cenários antes e depois da implantação da infraestrutura cicloviária e da comparação entre contagens volumétricas de ciclistas da RMBS, realizadas em vários pontos da rede viária, e a estimação da demanda cicloviária nestes pontos usando o modelo de escolha discreta, concluiu-se que o modelo permite identificar e quantificar os fatores e a forma como eles interferem na demanda cicloviária e que, portanto, os resultados podem ser usados para avaliar e direcionar as intervenções no sistema de transportes com o intuito de facilitar o uso do modo bicicleta. / The main aim of this work is to propose a procedure to identify and quantify the factors that influence the use of bicycles and to present how these factors can be used to evaluate and plan the deployment of segregated bike lanes and/or cyclelanes in an urban area. For attaining the aims, a method was developed and consisted firstly in to obtain socioeconomic data and urban travel data in places equipped with segregated bike lanes and/or cyclelanes available to the population and with counts of cyclists before and after the implementation of cycling infrastructure. Then, an experiment was conducted which consisted of characterization of the socioeconomic data and urban trips and cycling infrastructure from which a discrete choice model was estimated that allowed the identification of factors that influence the use of bicycles in a RMBS and was used to quantify the cycling demand on predetermined points. By the construction of scenarios before and after the implementation of cycling infrastructure and the comparison between counts of cyclists in a RMBS and the estimation of cycling demand in these points using discrete choice model, the main conclusion of this work is that the model allow us to identify and quantify the factors and how they interfere in a cycling demand. Therefore the results can be used to evaluate and direct interventions in the transport system in order to facilitate use of bicycle mode.
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Reconversion et aménagement durable des friches urbaines polluées : élaboration d'une méthode participative d'évaluation et d'aide multicritère à la décision / Sustainable contaminated brownfield redevelopment : implementation of a participatory multicriteriadecision aid support system

Tendero, Marjorie 31 May 2018 (has links)
La reconversion des friches urbaines est unepriorité pour préserver les sols. Ce sont souvent des sitespollués ; ce qui engendre de nombreux obstacles pour lesreconvertir. Les bénéfices découlant de la reconversionsont sous-estimés tandis que les coûts sont surestimés parles opérateurs techniques et fonciers. L’impact de lastigmatisation du site amène les riverains à ne pass’approprier les nouveaux usages. Le choix de ces usagespeut être à l'origine de conflits entre les parties prenantes.Cette thèse s'intéresse à la reconversion des frichespolluées en tenant compte à la fois de lamultidimensionnalité des parties prenantes, de leurspréférences, et de leurs perceptions. Nous étudions lesobstacles et les leviers pouvant être mobilisés pourpromouvoir leur reconversion à partir d’une enquête auprès de 76 opérateurs techniques et fonciers dans unepremière partie.Dans la seconde, nous analysonsl’importance des stigmates associés aux friches polluéesauprès des riverains et futurs usagers. Une premièreenquête, menée au niveau national (803 observations)analyse leurs perceptions, représentations et préférencesvis-à-vis de ces sites. Ces dernières sont précisées à l’aided’une expérience à choix discrets (338 observations)administrée sur cinq communes impactées par ce type desite. Dans une troisième partie, nous appliquons unedémarche d’aide multicritère à la décision participativedans le cas d’une friche urbaine polluée. Elle identifie lesprojets les plus consensuels en regroupant l’ensemble desparties prenantes. Ils corresponde / Brownfield redevelopment is a key priority topreserve soils. Brownfields are often contaminated yet.Therefore, it creates numerous obstacles to reuse them.Firstly, brownfields redevelopment’s benefits areunderestimated whereas costs are overestimated bydevelopers. Secondly, brownfields are plagued with thestigma effect. This effect persists even after remediationprocess (e.g., individuals may not use facilities on aformer contaminated brownfield). Thirdly, new uses cancause conflicts between the stakeholders. As such, thisthesis deals with contaminated brownfieldredevelopment taking into account both themultidimensionality of stakeholders, their preferencesand their perceptions. developers. In a first part, we study barriers to brownfieldredevelopment and how to tackle them using a surveyamong 76 French developers.In a second part, weanalyse the importance of the stigma associated withcontaminated brownfields. A first survey (803observations), conducted at national level, investigatesindividuals’ perceptions, representations and preferencesregarding brownfield redevelopment. A second survey(338 observations), conducted among five municipalitiesimpacted by such sites, specifies their preferences usinga discrete choice experiment. In the third part, we applya participatory multicriteria decision aid. It determinesthe most consensual projects in the case of acontaminated site. They correspond to individuals’preferences that were previously analysed.
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Valuing improvements in electricity supply using discrete choice experiments

Sagebiel, Julian 12 April 2017 (has links)
Um Strommärkte so zu konzipieren damit sie sowohl zur Verringerung der Nutzung fossiler Brennstoffe als auch zur Deckung des steigenden Energiebedarfes beitragen, ist Wissen über die Präferenzen der Konsumenten notwendig. Die vorliegende kumulative Dissertation untersucht Präferenzen für Elektrizitätsattribute von privaten Haushalten und trägt zu einem tieferen Verständnis dieser in unterschiedlichen Kontextsituationen bei. Der erste Artikel betrachtet statistische Methoden um die zwei am häufigsten angewandten Modelle – das Random Parameter Logit und das Latent Class Logit Modell – zu vergleichen. Der Artikel trägt dazu bei, den Prozess der Modellwahl zu verbessern und für die angewandte Forschung im Energiebereich anzupassen. Basierend auf den empirischen Ergebnissen des ersten Artikels untersucht der zweite Artikel die Präferenzen von privaten Haushalten in Hyderabad, Indien mit besonderem Fokus auf die physische Qualität der Energieversorgung. Die Ergebnisse deuten auf eine geringe Zahlungsbereitschaft der Konsumenten hin. Jedoch unterscheiden sich die Präferenzen der Haushalte. Die Artikel 3 und 4 basieren auf Datenerhebungen in Deutschland. Im dritten Artikel werden die Präferenzen privater Haushalte hinsichtlich der Organisationsform von Stromanbietern untersucht. Die Ergebnisse zeigen, dass die Kunden bereit sind mehr zu zahlen, wenn die Stromversorgung von Genossenschaften oder Stadtwerken übernommen wird. Der vierte Artikel betrachtet die Erfolgsfaktoren von Energiegenossenschaften in Deutschland. Die Ergebnisse zeigen, dass die Governance des Stromanbieters die Zahlungsbereitschaft für Strom beeinflussen. Insbesondere Genossenschaften werden den großen Privatunternehmen und Aktiengesellschaften vorgezogen. / In order to design electricity markets to simultaneously reduce the share of fossil fuels in energy production and meet the increasing demand for electricity, knowledge on consumer preferences is necessary. The goal of this cumulative dissertation is to contribute to the understanding of preferences of private households for electricity supply attributes in different contexts. In Paper 1 I review statistical methods to compare two frequently applied models, the random parameters logit and the latent class logit. The methods presented here can be readily used by other researchers and practitioners to better understand model performance which ultimately contributes to improving model choice in applied energy research. Based on the empirical findings of Paper 1, Paper 2 identifies preferences of private households in Hyderabad in India for electricity supply quality. The results indicate that willingness to pay for improvements are, on average, rather low. However, the preferences strongly vary between subjects. Papers 3 and 4 investigate preferences of German private households. In \textbf{Paper 3}, the respondents stated their preferences for the organization of the electricity distribution company under different renewable energy scenarios. It turned out that most people are willing to pay more for electricity supplied by municipally-owned companies and cooperatives. This additional willingness to pay increases disproportionally when the share of renewable energy is high. The paper identifies non-profit orientated distribution companies as potential drivers of the energy transition. Paper 4 investigates the determinants for the success of energy cooperatives in Germany. The results indicate that the governance of distribution companies impacts the choices of private households for electricity supply contracts. Especially, people preferred cooperative-like governance attributes.

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