Bakgrund: Skolbarn kan utsättas för onödig smärta vid vaccinering vilket kan leda till ofullständigt vaccinationsskydd samt minskat förtroende för hälso- och sjukvårdspersonal. I Sverige vaccineras barn i skolålder av skolsköterskan. Vaccinationer är den vanligaste orsaken till procedursmärta hos barn. Syfte: Att beskriva skolsköterskans omvårdnadsåtgärder för att minska smärta och oro vid vaccinering. Metod: Studien genomfördes som en allmän litteraturstudie baserad på 14 artiklar som kvalitetsgranskades och analyserades. Resultat: Avledning som omvårdnadsintervention är av betydelse vid vaccinering av skolbarn. Enligt litteraturstudiens resultat innebär avledning information/undervisning, medverkan, träning, miljöanpassning, specifik omvårdnad samt olika former av stöd och läkemedelshantering. Diskussion: Avledning utifrån resultatet är delvis överförbart till liknande situationer som till exempel venprovtagning. Trots att stöd finns för omvårdnadsåtgärd vid vaccinering saknas implementering för det. Slutsats: Skolsköterskan behöver identifiera barns behov och utifrån det välja omvårdnadsintervention. Skolsköterskan ska värna om en god kommunikation samt förtroendefull relation med barn. Vaccinationen kan då genomföras med minskad smärta och oro för barn. / Background: Schoolchildren may be exposed to unnecessary pain during immunization which might lead to incomplete vaccination protection and reduced confidence in healthcare professionals. In Sweden school aged children are vaccinated by the school nurse. Immunization is considered the most common reason for iatrogenic pain in children. Aim: To describe the school nurse’s interventions to reduce pain and anxiety. Methods: The study was conducted as a general literature review based on 14 articles which were quality examined and analysed. Results: Distraction as nursing intervention is of significance in immunization of schoolchildren. According to the result of the literature review distraction includes information/training, involvement, practice, environment adjustment, specific nursing, different form of support and medication. Discussion: Accordingto the result distractionis partly transmittable to similar situations such as venous sampling. Despite supporting evidence that distracting reduces pain and anxiety the interventions are not incorporated. Conclusion:The school nurse should identify the child’s needs and based on this select nursing intervention. The school nurse has to advocate good communication and trustful relation with the child. Immunization can then be conducted with decreased pain and anxiety.

A study by Ophir, Nass & Wagner found that younger adults who are heavy media multitaskers (HMM) perform worse on cognitive measures assessing inhibitory control. Previous findings indicated no benefit to being an HMM, however extrapolating from the aging literature wherein older adults can use distraction beneficially, the authors hypothesized that HMMs might show parallel gains. Two tasks (Reading with Distraction, and the Flanker task) are reported with regard to trait media multitasking preference in undergraduates. As expected, LMMs generally outperformed HMMs, but less consistently than predicted. The hypothesis was not proven; media multitaskers, while 4x more likely to recognize the implicit nature of the task, were not more likely to use previously distracting information suggesting that a different mechanism is operating in HMMs than older adults who readily use this information.

A study by Ophir, Nass & Wagner found that younger adults who are heavy media multitaskers (HMM) perform worse on cognitive measures assessing inhibitory control. Previous findings indicated no benefit to being an HMM, however extrapolating from the aging literature wherein older adults can use distraction beneficially, the authors hypothesized that HMMs might show parallel gains. Two tasks (Reading with Distraction, and the Flanker task) are reported with regard to trait media multitasking preference in undergraduates. As expected, LMMs generally outperformed HMMs, but less consistently than predicted. The hypothesis was not proven; media multitaskers, while 4x more likely to recognize the implicit nature of the task, were not more likely to use previously distracting information suggesting that a different mechanism is operating in HMMs than older adults who readily use this information.

Older adults inadvertently plagiarize more than young adults (McCabe, Smith, & Parks, 2007). One current explanation proposes that this effect can be understood in terms of age-related declines in working and episodic memory (McCabe et al., 2007). The current study tested this hypothesis by placing groups of young and older adult participants under divided attention while performing within the typical experimental paradigm. Results indicated that for some measures, dividing the attention of young adults equated their performance to older adults with full attention. For other measures, older adults still produced more errors. Except for false recall, regression analyses revealed that episodic and working memory accounted for age-related variance in these plagiarism errors. The current findings provide tenuous support for the McCabe et al. (2007) hypothesis and suggest other factors may be at play.

Thesis (Ph. D.)--Victoria University (Melbourne, Vic.), 2008. / Includes bibliographical references.

Bone is one of the few organs capable of regeneration after a substantial injury. As the bone heals itself after trauma, the coupling of angiogenesis to osteogenesis is crucial for the restoration of the skeletal tissue. In prior studies we have shown that Bone Morphogenetic Protein 2 (BMP2), a potent agonist for skeletal formation is expressed by vessels making it a prime candidate that links the morphogenesis of the two tissues. To investigate the role of BMP2 in the coordination of vessel and bone formation, we used a tamoxifen inducible Smooth Muscle Actin (SMA) promoter that conditionally expresses Cre recombinases crossed with a BMP2 floxed mouse in order to conditionally delete the BMP2 gene in smooth muscle actin (SMA) expressing cells. Using the mouse femur as our model for bone regeneration, we performed a surgical technique called distraction osteogenesis (DO) where an osteotomy is created followed by distraction or a gradual separation of the two pieces of bone. This primarily promotes intramembranous ossification at the osteotomy site by mechanical stimulation. Tamoxifen treatment started at day 6 and continued throughout the experiment. At post-operative days 3, 7, 12, 17, 24, and 31, we analyzed the bone and vessel formation by plain X-ray, micro-computed tomography (µCT) and vascular contrast enhanced µCT, and quantitative polymerase chain reaction (qPCR) of selective genes. We assessed both the femur and surrounding tissue to obtain qualitative and quantitative assessments for skeletal and vascular formation. Our results demonstrated that the deletion of BMP2 in vascular tissue resulted in a reduction of angiogenesis in vivo followed by a decrease in skeletal tissue development.

Driver's distraction is one of the main areas, which researchers are focusing on, in design of Advanced Drivers Assistance Systems (ADASs). Head pose and eye-gaze direction are two reliable indicators of a driver's gaze and the current focus of attention. Compared with other methods that make use of head pose only, methods that combine eye information can achieve higher accuracy. The naturalistic driving environment always presents unique challenges (e.g., unstable illumination, jolts, etc.) to video-based gaze estimation and tracking systems. Some methods can achieve relatively high proficiency in the stationary laboratory environment, but they may not be suitable for the unstable driving environment. In addition, performing in real time or near-real time is another consideration for gaze estimation in an ADAS. Therefore, these special challenges need to be overcome to design ADASs. In this thesis, we proposed a new driver's gaze zone estimation framework designed for the naturalistic driving environment. The framework combines head and eye information to estimate the gaze zone of the driver in both daytime and nighttime. The framework is composed of five main components: Facial Landmark Detection, Head Pose Estimation, Iris Center Detection, Upper Eyelid Information Extraction, and Gaze Zone Estimation. First, Constrained Local Neural Field (CLNF) is applied to obtain the facial landmarks in the image plane and the 3D model of the face in the object frame. In addition, extracting region of interest (ROI) is utilized as an optimization strategy for CLNF facial landmark detection. Second, head pose estimation can be regarded as a Perspective-n-Point (PnP) problem. Levenberg-Marquardt optimization method is used to solve the PnP problem based on the 2D landmark locations in the image plane and their corresponding 3D locations in the object frame. Third, a regression model-based method is employed to obtain the iris center from eye landmarks detected in the previous part. For upper eyelid information extraction, a quadratic function is utilized to model the upper eyelid, and the second-order coefficient is extracted. Finally, the head pose and the eye information are combined to form a feature vector, and Random Decision Forest classifier is utilized to estimate the current gaze zone of the driver from the feature vector extracted. The experiment is carried out in the realistic driving environment in both daytime and nighttime with three volunteers by Kinect sensor V2 for Windows that is put at the back of windshield. Weighted and unweighted accuracy are utilized as evaluation metrics in gaze zone estimation. Weighted accuracy evaluates gaze zones with different significance while unweighted accuracy treats each gaze zone equally. Experiment results show that the gaze zone estimation framework proposed in this work has better performance compared to the reference in the daytime. The weighted and unweighted accuracy of gaze zone estimation reach 96.6% and 95.0% for daytime, respectively. For nighttime, the weighted and unweighted accuracy can reach 96% and 91.4%.

Introdução: O uso de molas metálicas para o tratamento das craniossinostoses têm ganho cada vez mais espaço no arsenal terapêutico do cirurgião Crânio-Maxilo-Facial, na intenção de minimizar procedimentos extensos e mórbidos. Apesar da simplificação cirúrgica promovida pela mesma ainda persiste a necessidade de sua remoção. Objetivos: Realizar expansão craniana cirúrgica em modelo animal, utilizando-se de um implante (mola) totalmente integrado, confeccionado em blenda polimérica bioabsorvível. Testar sua eficácia e realizar análise histológica. Material e Métodos: Estudo experimental, aberto e prospectivo, utilizando doze coelhos fêmeas da raça New Zealand (Oryctolagus cuniculus) com seis semanas de vida. Os animais foram randomizados em dois grupos: controle (G1) aonde foi realizada craniectomia linear, e estudo (G2) aonde além da craniectomia foi inserida uma mola confeccionada a partir de uma blenda de POLI ÁCIDO LÁCTICO-CO-GLICÓLICO/POLI ISOPRENO, com o objetivo de realizar expansão craniana no sentido transversal à ostectomia. A movimentação craniana foi mensurada radiologicamente nas 12 semanas seguintes, através de marcadores e ao final foi realizada análise histológica para avaliação de reação inflamatória. Resultados: As molas confeccionadas apresentaram uma força média de 4,2N. A expansão craniana no grupo estudo no nível do marcador frontal foi de 9,6mm a 11,67mm e foi significante em relação a grupo controle. A análise histológica demonstrou pequena reação inflamatória. Conclusão: É possível a realização de expansão craniana em modelo animal utilizando-se uma mola bioabsorvível através de craniectomia linear, com boa tolerabilidade dos tecidos circunjacentes ao implante. / Introduction: The use of metal springs for the treatment of craniosynostosis have gaining more and more posicion in the therapeutic armory of the Craniofacial surgeon in the intention to minimize morbid and extensive procedures. Objectives: Perform cranial expansion surgery in an animal model, using an implant elastic (spring) fully integrated, made of bio-absorbable polymeric material. Test its efficacy and histological analysis Methods: An experimental study, open, prospective, using twelve New Zealand female rabbits (Oryctolagus cuniculus) with six weeks. The animals were randomized into two groups: control (G1) where linear craniectomy was performed and study (G2) where besides the craniectomy a spring made from a blend of POLY LACTIC ACID-CO-GLYCOLIC / POLI ISOPRENE, in order to perform cranial expansion in the transverse osteotomy. The cranial movement was assessed radiographically at 12 weeks following the surgical procedure and the final histological analysis was performed to evaluate the inflammatory reaction. Results: The springs made showed a medium force of 4,2N. The cranial expansion in the study group in the level of the frontal marker was of 9,6mm to 11,67 and was significant in relation to the control group. The histological analysis showed a small inflammatory reaction. Conclusion: It is possible to perform cranial expansion in an animal model using a bio-absorbable spring through the linear craniectomy. There was good tolerability of the surrounding tissues to the implant.

abstract: Despite the various driver assistance systems and electronics, the threat to life of driver, passengers and other people on the road still persists. With the growth in technology, the use of in-vehicle devices with a plethora of buttons and features is increasing resulting in increased distraction. Recently, speech recognition has emerged as an alternative to distraction and has the potential to be beneficial. However, considering the fact that automotive environment is dynamic and noisy in nature, distraction may not arise from the manual interaction, but due to the cognitive load. Hence, speech recognition certainly cannot be a reliable mode of communication. The thesis is focused on proposing a simultaneous multimodal approach for designing interface between driver and vehicle with a goal to enable the driver to be more attentive to the driving tasks and spend less time fiddling with distractive tasks. By analyzing the human-human multimodal interaction techniques, new modes have been identified and experimented, especially suitable for the automotive context. The identified modes are touch, speech, graphics, voice-tip and text-tip. The multiple modes are intended to work collectively to make the interaction more intuitive and natural. In order to obtain a minimalist user-centered design for the center stack, various design principles such as 80/20 rule, contour bias, affordance, flexibility-usability trade-off etc. have been implemented on the prototypes. The prototype was developed using the Dragon software development kit on android platform for speech recognition. In the present study, the driver behavior was investigated in an experiment conducted on the DriveSafety driving simulator DS-600s. Twelve volunteers drove the simulator under two conditions: (1) accessing the center stack applications using touch only and (2) accessing the applications using speech with offered text-tip. The duration for which user looked away from the road (eyes-off-road) was measured manually for each scenario. Comparison of results proved that eyes-off-road time is less for the second scenario. The minimalist design with 8-10 icons per screen proved to be effective as all the readings were within the driver distraction recommendations (eyes-off-road time < 2sec per screen) defined by NHTSA. / Dissertation/Thesis / Masters Thesis Computer Science 2015

abstract: This study exmaines the effect of in-vehicle infotainment display depth on driving performance. More features are being built into infotainment displays, allowing drivers to complete a greater number of secondary tasks while driving. However, the complexity of completing these tasks can take attention away from the primary task of driving, which may present safety risks. Tasks become more time consuming as the items drivers wish to select are buried deeper in a menu’s structure. Therefore, this study aims to examine how deeper display structures impact driving performance compared to more shallow structures. Procedure. Participants complete a lead car following task, where they follow a lead car and attempt to maintain a time headway (TH) of 2 seconds behind the lead car at all times, while avoiding any collisions. Participants experience five conditions where they are given tasks to complete with an in-vehicle infotainment system. There are five conditions, each involving one of five displays with different structures: one-layer vertical, one-layer horizontal, two-layer vertical, two-layer horizontal, and three-layer. Brake Reaction Time (BRT), Mean Time Headway (MTH), Time Headway Variability (THV), and Time to Task Completion (TTC) are measured for each of the five conditions. Results. There is a significant difference in MTH, THV, and TTC for the three-layer condition. There is a significant difference in BRT for the two-layer horizontal condition. There is a significant difference between one- and two-layer displays for all variables, BRT, MTH, THV, and TTC. There is also a significant difference between one- and three-layer displays for TTC. Conclusions. Deeper displays negatively impact driving performance and make tasks more time consuming to complete while driving. One-layer displays appear to be optimal, although they may not be practical for in-vehicle displays. / Dissertation/Thesis / Masters Thesis Human Systems Engineering 2018