<p>Purpose: The purpose of the present study was to illuminate how individuals living with SHR, experience its impact on accessibility, financial security and social relationships.</p><p>Method: A qualitative approach was used. The participants were recruited by advertising on the website for “The network for people with odor intolerance”. The data was collected by written descritive texts from the participants and analysed with qualitative content analysis.</p><p>Results: The results showed that the informants experienced an extensive lack of accessibility in society. It was difficult to move around in society, to visit public buildings and facilities and it was almost impossible to find a suitable place to live. Regarding financial security they had a reduced income due to difficulties to earn their living in combination with increased expenses because of the disease and they had difficulties to get the support they needed from authorities. This created an insecure financial situation. Further, the findings showed that their social relationships had been affected. Socializing with others had become hard and troublesome, they had become limited in doing social activities and they got support from some but these persons became limited. Six themes permeated the categories in all three content areas: “Being limited”, “Being forced to behave incompatible with your true personality”, “Experiencing a lack of understanding and respect from others”, “Experiencing insecurity”, “Being dependent on others” and “Being forced to choose between the plague and cholera”. <strong></strong></p> / <p>Syfte: Syftet med denna studie var att belysa hur individer som lever med sensorisk hyperreaktivitet (SHR) upplever dess påverkan på tillgänglighet, ekonomisk trygghet och sociala relationer.</p><p>Metod: Kvalitativ metod användes och deltagarna rekryterades via Internet genom annonsering på nätverket för doftöverkänsligas hemsida. Datainsamlingen skedde genom skrivna berättelser från deltagarna och data analyserades sedan med kvalitativ innehållsanalys.</p><p>Resultat: Resultatet visade att informanterna upplevde en omfattande brist på tillgänglighet i samhället. Det var svårt att röra sig i samhället, att besöka offentliga lokaler och inrättningar samt att det var nästan omöjligt att hitta en lämplig bostad. Deras ekonomiska trygghet var påverkad genom att de hade minskad inkomst på grund av svårigheter att försörja sig i kombination med ökade utgifter orsakade av sjukdomen samt att de hade svårigheter att få det stöd de behövde från myndigheter. Detta skapade en otrygg ekonomisk situation. Deras sociala relationer hade blivit påverkade av sjukdomen. Att umgås med andra hade blivit jobbigt och besvärligt, deras sociala aktiviteter hade blivit begränsade och de fick stöd av vissa men dessa personer blev då begränsade. Sex teman genomsyrade kategorierna i alla tre innehållsområdena: "Vara begränsad", "Vara tvungen att bete sig oförenligt med sin rätta personlighet", "Uppleva brist på förståelse och respekt från andra", "Uppleva otrygghet", "Vara beroende av andra" och "Vara tvungen att välja mellan pest eller kolera"</p>

Purpose: The purpose of the present study was to illuminate how individuals living with SHR, experience its impact on accessibility, financial security and social relationships. Method: A qualitative approach was used. The participants were recruited by advertising on the website for “The network for people with odor intolerance”. The data was collected by written descritive texts from the participants and analysed with qualitative content analysis. Results: The results showed that the informants experienced an extensive lack of accessibility in society. It was difficult to move around in society, to visit public buildings and facilities and it was almost impossible to find a suitable place to live. Regarding financial security they had a reduced income due to difficulties to earn their living in combination with increased expenses because of the disease and they had difficulties to get the support they needed from authorities. This created an insecure financial situation. Further, the findings showed that their social relationships had been affected. Socializing with others had become hard and troublesome, they had become limited in doing social activities and they got support from some but these persons became limited. Six themes permeated the categories in all three content areas: “Being limited”, “Being forced to behave incompatible with your true personality”, “Experiencing a lack of understanding and respect from others”, “Experiencing insecurity”, “Being dependent on others” and “Being forced to choose between the plague and cholera”. / Syfte: Syftet med denna studie var att belysa hur individer som lever med sensorisk hyperreaktivitet (SHR) upplever dess påverkan på tillgänglighet, ekonomisk trygghet och sociala relationer. Metod: Kvalitativ metod användes och deltagarna rekryterades via Internet genom annonsering på nätverket för doftöverkänsligas hemsida. Datainsamlingen skedde genom skrivna berättelser från deltagarna och data analyserades sedan med kvalitativ innehållsanalys. Resultat: Resultatet visade att informanterna upplevde en omfattande brist på tillgänglighet i samhället. Det var svårt att röra sig i samhället, att besöka offentliga lokaler och inrättningar samt att det var nästan omöjligt att hitta en lämplig bostad. Deras ekonomiska trygghet var påverkad genom att de hade minskad inkomst på grund av svårigheter att försörja sig i kombination med ökade utgifter orsakade av sjukdomen samt att de hade svårigheter att få det stöd de behövde från myndigheter. Detta skapade en otrygg ekonomisk situation. Deras sociala relationer hade blivit påverkade av sjukdomen. Att umgås med andra hade blivit jobbigt och besvärligt, deras sociala aktiviteter hade blivit begränsade och de fick stöd av vissa men dessa personer blev då begränsade. Sex teman genomsyrade kategorierna i alla tre innehållsområdena: "Vara begränsad", "Vara tvungen att bete sig oförenligt med sin rätta personlighet", "Uppleva brist på förståelse och respekt från andra", "Uppleva otrygghet", "Vara beroende av andra" och "Vara tvungen att välja mellan pest eller kolera"

Introduction De nombreuses études indiquent que la prématurité, qui représente 8 % des naissances, est associée à des indices précoces de dysfonction vasculaire, d’élévation de la pression sanguine et de survenue de diabète de type 2. Les enfants nés prématurément sont plus sujets aux blessures oxydatives de par l’immaturité de leurs défenses antioxydantes et de leur exposition à des situations pro-oxydantes (exposition à l’air ambiant, à un supplément d’oxygène, ou à une exposition aux infections). Cependant, les conséquences à long terme des blessures oxydatives induites par une exposition à l’oxygène en période périnatale restent méconnues. Le but de ce doctorat a été de mettre en évidence certains mécanismes pouvant relier les dommages de la prématurité induits par l’oxygène, et le risque à long terme de développer des maladies cardiovasculaires et métaboliques dans le concept global d’une programmation développementale de l’hypertension et des pathologies reliées au syndrome métabolique. Matériels et méthodes Des ratons Sprague-Dawley (SD) ont été exposés à 80 % O2 (O2) vs air ambiant (AA) du 3ème au 10ème jour de vie. Concernant les paramètres cardiovasculaires, nous avons mesuré au cours de la croissance, la pression sanguine à la queue (de la 4ème semaine à la 15ème semaine) et à l’âge adulte : la réactivité vasculaire à l’angiotensine II (AngII) et au carbachol (ex vivo, carotides) avec ou sans le tempol; la production d’oxyde nitrique (NO) en présence ou non L-arginine et de L-sépiaptérine (aorte, immunohistochimie) ainsi que l’expression de la nitric oxyde synthase endothéliale (eNOS) (aorte, immunohistochimie et western blot); le stress oxydant vasculaire (aorte, chemiluminescence) par la mesure de la production d’anions superoxide en présence ou non des inhibiteurs de la nicotinamide-adenine-dinucleotide-phosphate (NADPH oxydase) et de la nitric oxyde synthase endotheliale (eNOS), l’apocynine, et N-nitro-L-arginine methyl ester (L-NAME) respectivement, ainsi que le stress oxydant circulant par la mesure des niveaux plasmatiques de malondialdéhyde (MDA, HPLC); la densité microvasculaire a été évaluée au niveau du muscle tibial antérieur, immunohistochimie); la vitesse d’onde pulsée (VOP) (entre la valve aortique et juste avant la bifurcation ilio-fémorale) a été mesurée par ultrason; le nombre de néphrons a été compté par digestion acide. L’ontogenèse de la plupart de ces mécanismes a été regardée à l’âge de 4 semaines. Concernant les paramètres métaboliques, le poids a été mesuré au cours de la croissance. À l’âge adulte, la composition corporelle et la tolérance au glucose ont été évaluées. Résultats À l’âge de 4 semaines, aucune différence n’a été observée dans la pression sanguine, la réactivité vasculaire et le stress oxydant, mais chez les rats O2 vs AA, la densité microvasculaire est moindre, et des changements histologiques suggèrent la présence d’une rigidité artérielle augmentée. À l’âge adulte chez les rats O2 vs AA (n = 6-8 /groupe) : i) les pressions sanguines systoliques et diastoliques sont augmentées; ii) la réactivité vasculaire à l’AngII est augmentée et celle au carbachol est diminuée, le tempol prévient ces dysfonctions; iii) la production de NO est plus faible au niveau basal et après stimulation par le carbachol, mais est restaurée après la pré-incubation avec L-arginine et L-sépiaptérine; iv) l’expression d’eNOS est diminuée par immunohistochimie et augmentée par western blot; v) les niveaux d’anions superoxide, au niveau basal et en réponse à l’AngII, sont augmentés et sont induits par la NADPH oxydase et le non-couplage d’eNOS; vi) les niveaux plasmatiques de MDA sont augmentés; vii) La densité microvasculaire est moindre; viii) la VOP est augmentée; ix) le nombre de néphrons par rein est réduit; x) le poids est plus faible au cours de la croissance et un catch up est observé à l’âge adulte; la composition corporelle n’est pas différente entre les groupes; xi) la tolérance au glucose est diminuée. Conclusion Ces résultats supportent l’hypothèse d’une programmation développementale des maladies cardiovasculaires et métaboliques à l’âge adulte à la suite d’un stress hyperoxique néonatal. / Introduction Many studies showed that prematurity, which represents 8 % of birth, is associated with early indices of vascular dysfunction, increased blood pressure and Type 2 diabetes. Prematurity babies are more susceptible to oxidative injury, consequence of the immaturity of their antioxidant defences, and exposure to pro-oxidant situations (oxygen supplementation, infection). However, the long-term consequences of oxidative injury induced by oxygen exposure in the neonatal period are unknown. The aim of these PhD studies was to unravel some mechanisms that might underlie the damage induced by oxygen and the long-term risk of developing vascular and metabolic diseases in the overall concept of developmental programming of hypertension and metabolic syndrome-related diseases. Materials and methods Sprague-Dawley pups were kept with their mother in 80 % O2 (O2) or room air (RA) from day 3 to 10 of life. Cardiovascular parameters, tail blood pressure was measured between 4 and 15 weeks of life. In adulthood : vascular reactivity (ex vivo carotid rings) to angiotensine II (AngII) and carbachol with and without tempol was studied; studies of nitric oxide (NO) production with and without L-arginine and L-sépiaptérine (aorta, immunohistochemistry) and endothelial nitric oxide synthase expression (eNOS; aorta, immunohistochemistry, western blot) were performed; vascular oxidative stress (aorta, using chemiluminescence) by measuring superoxide anion production with and without inhibitors of nicotinamide-adenine-dinucleotide-phosphate (NADPH oxydase) and nitric oxyde synthase endotheliale (eNOS), apocynin and N-nitro-L-arginine methyl ester (L-NAME) respectively, and circulating oxidative stress by measuring the plasma levels of malondialdéhyde (MDA, HPLC) were evaluated; microvascular density was assessed on tibialis anterior muscle sections; pulse wave velocity (PWV) was measured by ultrasound, between aortic valve and ilio-femoral bifurcation; nephrons were counted after hydrochloric acid digestion. The main observations were also evaluated at 4 weeks of age. Metabolic parameters: body weight has been measured during the growth. In adulthood, body composition, glucose tolerance were evaluated. Results A 4 weeks of age, no difference was observed regarding blood pressure, vascular reactivity, and oxidative stress indices, but in rats O2 vs. RA (n = 6-8 /group), microvascular rarefaction and histological changes suggesting enhanced vascular stiffness were present. To adulthood, rats O2 vs. RA (n = 6-8/group) : i) systolic and diastolic blood pressures are increased; ii) vascular reactivity to Ang II is increased and to carbachol is decreased, these dysfunction were totally abolished by co-incubation of the vessel rings with tempol; iii) NO-production is decreased in basal condition and after carbachol stimulation, but is restored after pre-incubation of aorta sections with L- arginine and L-sépiaptérine; iv) eNOS expression is decreased by immunohistochemistry but increased by western blot; v) vascular superoxide anion levels are increased in basal condition, after AngII stimulation and this is mediated by NADPH oxydase and eNOS uncoupling; vi) the plasma levels of MDA are increased; vii) microvascular density is decreased; viii) PWV is increased; ix) nephron count per kidney is decreased; x) body weight is less during growth, but a catch up is observed in adulthood, body composition is similar; xi) the glucose tolerance is decreased in adults. Conclusion These results support the hypothesis of developmental programming of vascular and metabolic diseases in adulthood, after exposure to hyperoxic stress in the neonatal period. / Thèse réalisée dans le cadre d'une cotutelle entre l'Université de Montréal et l'Université d'Auvergne en France

Text in Afrikaans / Die doel van hierdie studie was om te bepaal waarom kinders uit kinderhuise wegloop en om voorstelle ter voorkoming daarvan te maak. Ten opsigte van die fenomeen "wegloop" stateer die literatuur dat kinders wegloop vanaf onaangename omstandighede en/of wegloop na aangename omstandighede. Die belewing van gesinstres, gesinskonflik, portuurgroepdruk, utopiese voorstellings van wegloop, onaangename skoolbelewing en tiener swangerskap is aangeduide rolspelers onderliggend aan bogenoemde. Die empiriese studie na wegloop uit kinderhuise bet aan die lig gebring dat kinders uit kinderhuise wegloop weens traumatiese belewing van verwydering uit die ouerhuis, etikettering en inrigtingsversadiging. Voorts is bevind dat faktore wat onderliggend aan bogenoemde is, tot 'n groot mate voorkom kan word. Sekere aanbevelings ter voorkoming van wegloop uit kinderhuise is na aanleiding van die studie gedoen en kan gebruik word in die volwassene se bemoeienis met die kinderhuiskind. / The object of the study was to identify the reasons why children run away from children's homes and to make recommendations on how to prevent them from running away. On considering "run away" as a phenomenon, the literature states that children run away from harsh circumstances to acceptable or pleasant circumstances. Experiences such as family stress, conflict in the family, peer group pressure, romanticising the idea, harsh school experiences and teenage pregnancies are roll players subjacent to the above mentioned. The empirical study of "running away from children's homes" has confirmed that children run away because of traumatic separation from parental homes, labelling and institutional intolerance. Furthermore it was also found that factors subjacent to the above mentioned can be neutralised to a large extent. Certain guidelines have been recommended for adults when confronted with children in children's homes. / Psychology of Education / M. Ed. (Voorligting)

Submitted by Maike Costa (maiksebas@gmail.com) on 2017-07-17T14:24:25Z No. of bitstreams: 1 arquivototal.pdf: 1497212 bytes, checksum: d5d2c8fedaa2465aacbdbf84d14e16ed (MD5) / Made available in DSpace on 2017-07-17T14:24:25Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 1497212 bytes, checksum: d5d2c8fedaa2465aacbdbf84d14e16ed (MD5) Previous issue date: 2016-12-06 / The number of religious intolerance denouncements has recently increased, especially those against African-Brazilian religions. Would be this kind of prejudice related to Brazilian racial prejudice? Justified discrimination theory alleges that the legitimating myth to disguise racial prejudice, on this case, would be the demonization of AfricanBrazilian religious beliefs. Under this theory it was investigated the degree of relationship between African-Brazilian religions discrimination, racial prejudice, prosperity theology, kind and strength of religion, and right-wing authoritarianism as well as which of these factors mediates the relation of religion/religiosity and discrimination. To accomplish this, two studies were done (college students, N = 300; devotees of different kinds of Christianism, N = 519) using a specific scale to measure each construct. The AfricanBrazilian religions discrimination scale was well-succeed (α = 0,84) as well as the religion/religiosity one (α = 0,94). Neopentecostals and Protestants discriminate more African-Brazilian religions. Catholics, atheists and non-religious are more tolerant. It was concluded that neither racism, nor prosperity theology, but right-wing authoritarianism construct is the mediator between religion/religiosity and religious discrimination (Z of Sobel = 7,95; p = 0,001 e 8,24; p = 0,01 in each study, respectively). It is the first study of this kind in Brazil, and a surprising result that demands prudency on its interpretation. / Atualmente cresceu o número de denúncias de intolerância religiosa, especialmente contra as religiões de matriz africana. Haveria relação entre este preconceito religioso e o preconceito racial brasileiro? A Teoria da Discriminação Justificada alega que o mito legitimador do disfarce do preconceito racial seria, neste caso, a diabolização das crenças religiosas afro-brasileiras. Com este marco teórico, investigou-se em que medida a discriminação contra as religiões de matriz africana, o preconceito racial, a teologia da prosperidade, o tipo de religião e grau de religiosidade, e o autoritarismo de direita estão relacionados e quais destes fatores medeiam a relação entre religião/religiosidade e discriminação. Para isto, realizaram-se dois estudos (estudantes universitários, N = 300 e fiéis de diversos cristianismos, N = 519, respectivamente) onde se utilizou uma escala para cada construto. A escala de discriminação contra religiões afro-brasileiras mostrouse satisfatória (α = 0,84) assim como a de religião/religiosidade (α = 0,94). Os neopentecostais e protestantes discriminaram mais as religiões afro-brasileiras. O grau de religiosidade também predisse diretamente este preconceito. Católicos, ateus e semreligião mostraram-se os mais tolerantes. Concluiu-se que nem o racismo, nem a teologia da prosperidade como defendido por vários estudiosos, mas o autoritarismo de direita é o construto que medeia a relação entre o tipo de religião/religiosidade e a discriminação contra religiões afro-brasileiras (Z de Sobel = 7,95; p = 0,001 e 8,24; p = 0,01, em cada estudo, respectivamente). É o primeiro estudo do tipo no Brasil, e um resultado surpreendente que pede cautela na sua interpretação. / Actualmente se incrementó el número de quejas de intolerancia religiosa, especialmente contra las religiones de origen africano. Hay relación entre este prejuicio religioso y el prejuicio racial de Brasil? La Teoría de la Discriminación Justificada plantea que el mito legitimador del disfraz de los prejuicios raciales sería, en este caso, la demonización de las creencias religiosas afro-brasileñas. Con este marco teórico, se investigó el grado en que la discriminación contra las religiones de origen africano, los prejuicios raciales, la teología de la prosperidad, el tipo de la religión y el grado de religiosidad, y el autoritarismo de derecha están relacionados y cuáles de estos factores son mediadores de la relación entre la religión / religiosidad y la discriminación. Para esto, hubo dos estudios (estudiantes universitarios, N = 300 y fiel de varios cristianismos, n = 519, respectivamente) donde se utilizó una escala para cada constructo. La escala de discriminación contra las religiones afro-brasileña fue satisfactoria (α = 0,84), así como la de religión / religiosidad (α = 0,94). Los neo-pentecostales y protestantes discriminaron más las religiones afro-brasileñas. El grado de religiosidad también predijo directamente este prejuicio. Católicos, ateos y los no religiosos resultaron ser los más tolerantes. Se concluyó que ni el racismo ni la teología de la prosperidad, como defendido por muchos estudiosos, pero el autoritarismo de derecha es el constructo que media la relación entre el tipo de religión / religiosidad y la discriminación contra las religiones afro-brasileñas (Z Sobel = 7,95; p = 0,001 a 8,24; p = 0,01 en cada estudio, respectivamente). Es el primer estudio de su tipo en Brasil, y un resultado sorprendente que pide prudencia en su interpretación.

Submitted by Natalia de Souza Gonçalves (natalia.goncalves@ufpe.br) on 2016-10-10T13:09:11Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) GALENO EGYDIO - COLACAO DE GRAU.pdf: 1509311 bytes, checksum: f4dc67e7a0e6a1a9159df433631ba569 (MD5) / Made available in DSpace on 2016-10-10T13:09:12Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) GALENO EGYDIO - COLACAO DE GRAU.pdf: 1509311 bytes, checksum: f4dc67e7a0e6a1a9159df433631ba569 (MD5) Previous issue date: 2014-02-19 / O uso de anel na derivação gástrica em Y de Roux (DGYR) está associado à intolerância alimentar pós-operatória, cujo tratamento clássico tem sido a remoção cirúrgica. Um novo método utilizando prótese plástica autoexpansível (PPAE) induz erosão intragástrica do anel, o qual é removido por via endoscópica de forma minimamente invasiva. Objetiva-se analisar a eficácia e a segurança dessa técnica de remoção de anel após DGYR. Estudo prospectivo longitudinal de série de 41 pacientes com intolerância alimentar associada à presença de anel, que foram, tratados por via endoscópica, entre 2007 e 2013. O grupo apresentava média de idade igual a 44,1 anos, IMC médio de 27,0 Kg/m², e vômitos foram os sintomas mais frequentes (n=37), com ocorrência diária em 46,3%. O sucesso terapêutico foi definido como a melhora dos sintomas após a remoção do anel. O implante de PPAE foi realizado sob anestesia geral e guiado por radioscopia, sendo utilizado endoscópio padrão. Os pacientes receberam alta após 24 horas com dieta líquida e inibidor de bomba de prótons (IBP), que foi prescrito durante o tempo médio de permanência da PPAE, que foi de 15,3 dias. A prótese promoveu erosão completa de anel em 24 (58,5%) pacientes e no grupo restante, a remoção em segundo estágio após 7 dias com pinça de corpo estranho. Houve três casos de migração da prótese com eliminação espontânea por via retal. O efeito adverso mais comum foi vômito (n=7). Não houve complicações graves, nem necessidade de remoção precoce da prótese. Após seguimento médio de 6 meses, não houve mudança significativa no IMC e 78% dos pacientes foram capazes de ingerir carne vermelha. A remoção do anel com uso de prótese endoscópica demonstrou ser um procedimento seguro e eficaz, com100% dos anéis sendo removidos com sucesso e 29,3% de ocorrência de eventos adversos leves (vômitos). Esta técnica é uma alternativa adequada na remoção do anel, evitando a intervenção cirúrgica e reduzindo a possibilidade de reganho de peso. / Ring dysfunction after roux-en-y gastric bypass (RYGB) causing delayed gastric emptying on Fobi pouch is classically treated by surgical ring removal. In a novel way of using selfexpandable stents, intraluminal erosion of the ring is achieved, allowing its removal by endoscopy, with no need of surgery. No study has shown clinical applicability of this principle in RYGB banded with silastic ring. In this case series we analyze endoscopic removal of noneroded dysfunctional rings after RYGB using self-expandable plastic stents (SEPS). This is a prospective case series of 41 patients with delayed gastric emptying secondary to extrinsic compression of the ring after RYGB between 2007 and 2013. Successful ring removal, symptoms improvement, weight control and adverse events were evaluated. Mean age of subjects was 44.1 years, median BMI at treatment was 27.0 Kg/m2. Most common symptom was vomiting (n=37), with daily occurrence in 46.3%. Success was defined as symptoms improvement after stent and ring removal. SEPS placement was done under general anesthesia and fluoroscopic guidance. A standard gastroscope (Pentax Medical, Montvale, NJ), and a PolyflexTM stent (25x21x150mm) (Boston Scientific, Natick, MA) were used in all cases. All patients were discharged after a 2-hour observation period, with liquid diet and proton pump inhibitor. SEPS induced complete erosion in 24 patients, allowing for simultaneous stent and ring removal. The median time of stenting was 15 days. There was one case of stent migration, which was naturally expelled. Most common adverse event was vomiting (n=7). There was no early stent removal, and no serious complications. After a mean follow-up of 6 months, there was no significant change in mean BMI, and 78% of patients are able to ingest solid foods. Endoscopic stents led to ring intraluminal erosion in 100% of subjects, allowing for successful removal of dysfunctional rings. The procedure is technically feasible and safe, with a 29.3% occurrence of mild adverse events (vomiting), and no serious complications. It proved to be a reasonable alternative for ring removal in our casuistic, avoiding surgery, and decreasing the possibility of weight regain.

Hintergrund Ein rascher enteraler Nahrungsaufbau bei Frühgeborenen verkürzt die Zeit der parenteralen Ernährung. Somit lassen sich bestimmte Risikofaktoren beeinflussen, die evt. die Morbiditätshäufigkeit der Kinder senken könnten. Mehrere Kohortenstudien zeigten, dass ein standardisierter Nahrungsaufbau mit einer geringeren Komplikationsrate und einem schnelleren Nahrungsaufbau assoziiert ist. Ziel der Studie ist zu überprüfen, ob ein standardisiertes Ernährungsprogramm einen rascheren und komplikationsärmeren enteralen Nahrungsaufbau bei Frühgeborenen ermöglicht. Patienten und Methode In die vorliegende randomisierte, kontrollierte Studie wurden 99 Frühgeborene mit einem Geburtsgewicht von ≤1750 g aufgenommen. In der Gruppe mit standardisierter Ernährung (ST) wurde der enterale Nahrungsaufbau mit Muttermilch oder gespendeter Frauenmilch nach einem speziell ausgearbeiteten Protokoll durchgeführt. In der Gruppe mit der individuellen Ernährungsform (IN) wurde je nach Bedarf und Zustand des Kindes auch semi-elementare Nahrung (Pregomin®) gefüttert. Über die Steigerungsdynamik und Nahrungspausen wurde hier individuell entschieden. Primäres Zielkriterium war die Dauer bis zum Erreichen der vollenteralen Ernährung. Ergebnisse In der ST-Gruppe war die vollständig enterale Ernährung nach 14,93 ± 9,95 (Median 12) Tagen, in der IN-Gruppe nach 16,23 ± 10,86 (Median 14) Tagen möglich. Es konnte kein signifikanter Unterschied gefunden werden. Nur bei hypotrophen Frühgeborenen erwiesen sich die Unterschiede bei der ST-Gruppe gegenüber der IN-Gruppe als statistisch signifikant: 10,20 ± 4,78 (Median 8,5) vs. 16,73 ± 8,57 (Median 15) Tage (p = 0,045). Die Gewichtsentwicklung verlief in beiden Studiengruppen nicht different. Die Kinder in der ST-Gruppe konnten bei einem Gewicht von 116% des Geburtsgewichtes vollständig enteral ernährt werden, in der IN-Gruppe bei einem Gewicht von 122% des Geburtsgewichtes. Die Inzidenz der nekrotisierenden Enterokolitis (4%) und anderer Komplikationen blieb in beiden Studiengruppen niedrig. Die Diagnose „Ernährungsschwierigkeiten“ wurde mit klaren Symptomen definiert und in der IN-Gruppe doppelt so oft gestellt, wie in der ST-Gruppe (14 vs. 7) Schlussfolgerung Das Standardisieren führte unter den Studienbedingungen nicht zu einer Beschleunigung des Nahrungsaufbaus. Anhand unserer Ergebnisse ist es möglich, dass die hypotrophen Frühgeborenen von der standardisierten Ernährung entsprechend des Ernährungsprotokolls profitieren. Diese Hypothese muss in einer neuen Studie überprüft werden. Diese Kinder konnten schneller vollständig enteral ernährt werden, als Frühgeborene, mit individuellem enteralem Nahrungsaufbau. Ein standardisiertes Nahrungsprotokoll ist im klinischen Alltag durchsetzbar, und darauf aufbauend ein enteraler Nahrungsaufbau unter strenger klinischer Beobachtung ohne Komplikationen erfolgreich durchführbar.

Once seen as a disease of wealthy nations, type 2 diabetes mellitus is now showing unprecedented growth throughout the world, fueling increases in microvascular and macrovascular complications. A compelling and growing body of evidence suggests that glucose intolerance and insulin resistance, hallmarks of the diabetic patient, may be driven by chronic inflammation. In particular, a predominance of visceral fat has been associated with enhanced inflammatory cytokine secretion that may contribute to enhanced risk of diabetes and comorbid cardiovascular disease in these individuals. As a function of its potency and wide environmental and biological distribution, we hypothesized that bacterial lipopolysaccharide (LPS, also known as endotoxin) may promote adipose inflammation and concomitant metabolic dysfunction. Indeed, expression of the LPS receptor CD14 is enhanced on visceral adipocytes of ob/ob mice, paralleling enhanced IL-6 secretion ex vivo. Furthermore, rosiglitazonefed ob/obmice demonstrated a reduction in CD14 that coordinated with diminished IL-6 secretion, suggesting a basis for the touted anti-inflammatory effects of this commonly employed type 2 diabetes medication. Mice deficient in components of the LPS signaling cascade, namely CD14, TLR4, and MyD88, yielded adipocytes with markedly attenuated IL-6 secretion, corroborating the central importance of LPS in adipocyte inflammation and supporting the role of this signaling pathway in depot-specific inflammation. Despite the prominent role of LPS signaling in adipocyte inflammation, CD14-, TLR4-, and MyD88-deficient mice failed to show resistance to diet induced obesity. Surprisingly, cd14-/- and tlr4-/- mice had marked glucose intolerance without alteration in total weight or adipose accumulation. In contrast, myd88-/- mice revealed minor glucose intolerance only with high fat diet challenge at an advanced age despite being overtly obese. In cd14-/- and tlr4-/-, but not myd88-/-, mice, an exaggerated rebound to hypoglycemia was associated with enhanced norepinephrine secretion, which could be abrogated by the adrenergic β-blocker propranolol. The overlay of these mouse models reveals a divergence of phenotypes that demonstrate LPS signaling disruption may lead to glucose intolerance and insulin resistance in part due to enhanced sympathoadrenal tone, uncovering an essential role of innate immunity in physiological stress and its impact upon glucose homeostasis.

This study examines a type of moral conflict, a conflict of values. This through the method qualitative text analysis. To gain an understanding of this problem, insight into previous research is required. Previous research mainly deals with the issue of religion in the public sphere, including literature that concerns research fields on ethical moral philosophy and sociology. Therefore, to obtain in whose conditions are prioritized according to the public Islamic call to prayer in Sweden. Initially, the Declaration of Human Freedoms and Rights is presented, whereupon the question of refrain religious content is of interest. Hence, examine the tolerance and intolerance according to whose practice might contain limits. By starting from two selected theorists with different backgrounds, whereupon their research areas are separated. Examine their positions on the issue of moral value conflict. One of them has conducted social science research and the other is better known as a religious critic and neuroscientist. Through their theory formation, create an idea of how this conflict of values can be understood and interpreted. The public Islamic call to prayer will remain as the main theme of this study, which corresponds as the result of this study. The conclusion is clearly demonstrating various standpoints in this moral dilemma, different aspects are truly extensive. During investigation of different point of views, the purpose remains to state alternative explanations of understanding, and how to interpret the main conflict of value. A majority group in the society whose terms are privileged compared to a non-majority group. Different positions are clear in the result, whereupon the question of allowing public Islamic call to prayer, can thus be interpreted in different ways. Faiths, different beliefs, religion and culture, are numerous variables which had been studied in more detail to then be discussed in relation to the main question and the purpose, a moral conflict of value.

Объектом исследования явился перфекционизм. Предметом исследования стала связь перфекционизма с экзистенциальной исполненностью, толерантностью-интолерантностью к неопределенности и формально-динамическими свойствами индивидуальности. Магистерская диссертация состоит из введения, двух глав, заключения и списка литературы (66 источников). Объем магистерской диссертации 83 страницы, на которых размещены 13 таблиц и 8 рисунков. Во введении раскрывается актуальность проблемы исследования, разработанность проблематики, ставятся цель и задачи исследования, определяются объект и предмет исследования, формулируются гипотезы, указываются методы и эмпирическая база, а также этапы проведения исследования, научная новизна, теоретическая и практическая значимость работы. Первая глава включает в себя обзор иностранной и отечественной литературы по теме «перфекционизм». Также включены разделы, описывающие экзистенциалььную исполненность, формально-динамические свойства индивидуальности и толерантность-интолерантность к неопределенности. Выводы по первой главе представляют собой итоги по изучению теоретического материала. Вторая глава описывает эмпирическую часть исследования. Представлено описание организации и методов проведенного исследования, а также полученных результатов. В исследовании были использованы методики: «Многомерная шкала перфекционизма» П. Хьюитта и Г. Флетта в адаптации И. И. Грачевой; «Дифференциальный тест перфекционизма», оригинальная методика А. А. Золотаревой; опросник формально динамических свойств индивидуальности (ОФДСИ-26), сокращенный В. М. Русалова; «Диагностика экзистенциальной исполненности» (авторы В. Б. Шумский, Е. М. Уколова, Е. Н. Осин, Я. Д. Лупандина); «Новый опросник толерантности-интолерантности к определенности» Т. В. Корниловой, контент-анализ. По итогам эмпирического исследования представлены результаты сравнительного, корреляционного и регрессионного анализа. Определено, что адаптивный перфекционизм положительно связан с активностью и отрицательно-с эмоциональностью. Также адаптивный перфекционизм положительно связан со всеми параметрами экзистенциальной исполненности, тогда как связь с толерантностью к неопределенности отсутствует. Напротив, дезадаптивный перфекционизм положительно связан с эмоциональностью во всех сферах и отрицательно – с активностью и экзистенциальной исполненностью. Дезадаптивный перфекционизм связан со всеми параметрами дифференциальной модели перфекционизма П. Хьюитта и Г. Флетта, а именно, с перфекционизмом, ориентированным на себя, на других и с социально предписанным перфекционизмом. При этом перфекционизм, ориентированный на себя, отрицательно связан с параметрами экзистенциальной исполненности «Бытие-в-мире» и «Самоценность». Перфекционизм, ориентированный на других, отрицательно связан с параметрами экзистенциальной исполненности «Бытие в-мире», «Ценность жизни» и «Самоценность». Социально предписанный перфекционизм отрицательно коррелирует со всеми параметрами экзистенциальной исполненности. В результате регрессионного анализа было определено, что предиктором адаптивного перфекционизма со стороны формально динамических свойств индивидуальности является высокая активность, а со стороны экзистенциальной исполненности – параметры «Ценность жизни» (отрицательный вклад), «Самоценность» и «Смысл» (положительный вклад). Предиктором дезадаптивного перфекционизма со стороны формально динамических свойств индивидуальности является высокая эмоциональность, а со стороны экзистенциальной исполненности – параметр «Бытие-в-мире» (отрицательный вклад). В заключении обобщены результаты теоретической и эмпирической частей работы, выводы по выдвинутым гипотезам, обоснована практическая значимость исследования и описаны перспективы дальнейшей работы в данной проблематике. / The object of the study was perfectionism. The subject of the study was the relationship of the perfectionism with existential fulfillment, tolerance-tolerance to uncertainty and formal-dynamic properties of individuality. The master's thesis consists of an introduction, two chapters, a conclusion and a list of references (66 sources). The volume of the master's thesis is 82 pages, which contain 13 tables and 8 figures. The introduction reveals the relevance of the research problem, the elaboration of the problem, sets the purpose and objectives of the study, defines the object and subject of the study, formulates the main and additional hypotheses, specifies the methods and empirical base, as well as the stages of research, scientific novelty, theoretical and practical significance of the work. The first chapter includes a review of foreign and domestic literature on the topic of "perfectionism". Also included are sections describing existential fulfillment, formal-dynamic properties of individuality and tolerance-intolerance to uncertainty. The conclusions of the first chapter are the results of the study of theoretical material. The second chapter describes the empirical part of the study. The description of the organization and methods of the conducted research, as well as the results obtained, is presented. The following methods were used in the study: "Multidimensional scale of perfectionism" by P. Hewitt and G. Flett in the adaptation of I. I. Gracheva; "Differential test of perfectionism", the original method of A. A. Zolotareva; questionnaire of formally dynamic properties of individuality (OFDSI-26), abbreviated by V. M. Rusalov; "Diagnostics of existential fulfillment" (authors V. B. Shumsky, E. M. Ukolova, E. N. Osin, Ya. D. Lupandina); "A new questionnaire of tolerance-intolerance to certainty" by T. V. Kornilova, content analysis. Based on the results of the empirical study, the results of comparative, correlation and regression analysis are presented. It is determined that adaptive perfectionism is positively associated with activity and negatively with emotionality. Adaptive perfectionism is also positively associated with all parameters of existential fulfillment, while there is no connection with tolerance to uncertainty. On the contrary, maladaptive perfectionism is positively associated with emotionality in all spheres and negatively with activity and existential fulfillment. Maladaptive perfectionism is associated with all the parameters of the differential model of perfectionism by P. Hewitt and G. Flett, namely, with perfectionism focused on oneself, on others and with socially prescribed perfectionism. At the same time, self-oriented perfectionism is negatively associated with the parameters of existential fulfillment of "Being-in-the-world" and "Self-worth". Perfectionism, focused on others, is negatively associated with the parameters of existential fulfillment "Being in the world", "Value of life" and "Self-worth". Socially prescribed perfectionism negatively correlates with all parameters of existential fulfillment. As a result of regression analysis, it was determined that the predictor of adaptive perfectionism from the formally dynamic properties of individuality is high activity, and from the existential fulfillment – the parameters "Value of life" (negative contribution), "Self-worth" and "Meaning" (positive contribution). The predictor of maladaptive perfectionism on the part of the formally dynamic properties of individuality is high emotionality, and on the part of existential fulfillment is the "Being–in-the-world" parameter (negative contribution). In conclusion, the results of the theoretical and empirical parts of the work are summarized, conclusions on the hypotheses put forward, the practical significance of the study is substantiated and the prospects for further work in this area are described.