Die Interstitielle Zystitis / Bladder Pain Syndrome (IC/BPS) ist eine chronische Erkrankung der Harnblase, deren Ätiologie und Pathogenese nicht abschließend geklärt ist. Es wird von einem multifaktoriellen Geschehen ausgegangen. Eine Rolle spielt dabei ein verändertes Expressionsmuster muskarinerger Acetylcholinrezeptoren (mAChR) in Detrusorzellen. Allerdings zeigt sich keine Korrelation zwischen der Rezeptor-Protein- und -Gen-Expression. Eine mögliche Erklärung könnte ein verändertes Rezeptor-Trafficking liefern. Ziel dieser Arbeit war es daher, das intrazelluläre Trafficking der mAChR M2 und M3 im Detrusor von IC-Gewebe zu untersuchen. Dies erfolgte mittels Proximity Ligation Assay und konfokaler Laser Scanning Mikroskopie an Paraffinschnitten von sieben weiblichen IC-Biopsien. Mit dieser Methoden konnten tatsächlich Veränderungen im Trafficking von M2 und M3 detektiert werden, die dazu beitragen können, die Pathogenese der Erkrankung besser zu verstehen.

Electronic devices today are an integral part of human life thanks to state-of-the- art complementary metal oxide semiconductor (CMOS) technology. The progress in this area can be attributed to miniaturization driven by Moore’s Law. Further advancements in electronics are under threat from physical limits in dimensional scaling and hence new roadmaps for alternative materials and technologies are chased. Furthermore, the current era of Internet of things (IoT) and Internet of everything (IoE) has broaden the horizon to a plethora of unprecedented applications. The most prominent emerging fields are flexible and stretchable electronics. There has been significant progress in developments of flexible sensors, transistors, and alternative materials, etc. Nonetheless, there remains the unaddressed challenges of matching performance of the status-quo, packaging, interconnects, and lack of pragmatic integration schemes to readily complement existing state-of-the-art technology. In this thesis, a pragmatic heterogeneous integration strategy is presented to obtain high-performance 3D electronic systems using existing CMOS based integrated circuit (IC). Critical challenges addressed during the process are: reliable flexible interconnects, maximum area efficiency, soft-polymeric packaging, and heterogeneous integration compatible with current CMOS technology. First, a modular LEGO approach presents a novel method to obtain flexible electronics in a lock-and-key plug and play manner with reliable interconnects. A process of converting standard rigid IC into flexible LEGO without any performance degradation with a high-yield is shown. For the majority of healthcare and other monitoring applications in IoT, sensory array is used for continuous monitoring and spatiotemporal mapping activities. Here we present ultra-high-density sensory solution (1 million sensors) as an epitome of density and address each of the associated challenges. A generic heterogeneous integration scheme has been presented to obtain physically flexible standalone electronic system using 3D-coin architecture. This 3D-coin architecture hosts sensors on one side, readout circuit and data processing units embedded in the polymer, and the other side is reserved for antenna and energy harvester (photovoltaic). This thin platform (~ 300 μm) has achieved bending radius of 1 mm while maintaining reliable electrical interconnection using through-polymer-via (TPV) and soft-polymeric encapsulation. This coin integration scheme is compatible with existing CMOS technology and suitable for large scale manufacturing. Lastly, a featherlight non-invasive ‘Marine-Skin’ platform to monitor deep-ocean monitoring is presented using the heterogeneous integration scheme. Electrical and mechanical characterization has been done to establish reliability, integrity, robustness, and ruggedness of the processes, sensors, and multisensory flexible system.

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<p>  </p> <p>Global hospitality and tourism activities are becoming increasingly diverse in the profile of international visitors as well as in the destination communities that host them. Along with the geographic and demographic shifts, today’s hospitality and tourism employees not only come from multicultural backgrounds themselves but also serve and interact with guests and visitors of different cultures from all over the world. The study was conducted against this backdrop and focused on intercultural competence and intercultural learning in four-year hospitality and tourism programs in the universities of the United States. The purpose of the study is to advance intercultural learning of hospitality and tourism undergraduate students through forward-looking curriculum design. Specifically, the study aims to 1) analyze the extent to which intercultural learning is embedded in current hospitality and tourism programs; 2) identify the intercultural competence in undergraduate students presently enrolled in the programs and effective formats for students’ intercultural learning; 3) evaluate desirable learning materials, approaches, and assessments of intercultural learning from the perspectives of students, educators, and industry professionals; and 4) propose a model of and make recommendations for intercultural learning through curriculum design.</p> <p>A series of mixed methods were adopted to achieve the research goal and objectives. They include descriptive and semantic analyses, a self-administered survey questionnaire, and semi-structured in-depth interviews. The data were collected from 53 four-year bachelor’s hospitality and tourism programs in public or land-grant universities. The results of descriptive and semantic analyses show that clear and direct statements and content about intercultural learning are lacking in general program literature as well as in specific course syllabi. Results of survey questionnaire data demonstrate that the intercultural competence level of undergraduate students in hospitality and tourism programs is neither high nor low. The most effective format for intercultural learning is through personal involvement and interaction. Intercultural activities organized by the university and community are examples of this format. The findings from the interviews reveal the core characteristics of intercultural learning materials, approaches, and assessments. The learning materials need to be current, visualized, and industry-focused. The learning approaches should be interactive and active to place students in the center during their intercultural learning process. The learning assessments are expected to provide opportunities and platforms for students to share their experiences and reflect on what they have learned from intercultural courses. Based on the key findings from the study, a conceptual model of intercultural learning through curriculum design is proposed for hospitality and tourism programs. </p> <p>The study makes some theoretical and practical contributions. Theoretically, the study enriches the literature on intercultural learning and intercultural competence in hospitality and tourism from the curriculum design viewpoint and multiple perspectives of students, educators, and industry professionals. The research integrates intercultural curriculum and internationalization at home into an innovative learning approach to facilitate students’ intercultural learning. The proposed model lays a conceptual foundation for future academic discourse and empirical research. Practically in the educational context, the study offers guidelines for hospitality and tourism programs to develop and design intercultural curriculum through an illustration of an introductory tourism course. The study contextualizes intercultural learning as involving two or more world cultures. The findings are significant in intracultural and subcultural settings as well. The expectations of guests and visitors, be they international or domestic, are influenced by their primary cultures and subcultures alike. Hospitality businesses and tourism organizations can provide a higher level of service quality to their guests and visitors from diverse cultural backgrounds if their employees are interculturally competent through education and training and other human resource functions. </p> <p>The findings from the study bear implications beyond higher education and hospitality and tourism. The study suggests that hospitality businesses and tourism organizations can contribute to building an inclusive community when they are staffed by interculturally competent employees. There have been increasing occurrences of direct and indirect forms of prejudice, discrimination, group profiling, social exclusion, and even hostility both in the United States and around the globe. While these occurrences are rooted in historical, geopolitical, and ideological contexts, they also result from the absence or lack of cultural understanding. Intercultural competence through intercultural learning plays a direct role in promoting harmony and inclusiveness on campus, in the workplace, and in society at large. </p>

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With solar power and other renewables set to take over the market in the coming decades, maximum power point tracking will be essential to optimizing power output. One underserved topic of research is the effect of inductor current ripple on performance of Maximum Power Point Tracking (MPPT) algorithms. Many new topologies are focused on decreasing the ripple from PV source to increase efficiency and power output. However, not much has been done to show ripple degrading performance of MPPT algorithms. This study uses a boost converter topology to test the performance of constant duty cycle step Perturb and Observe (PO), Incremental Conductance IC, and Constant Voltage (CV) PID over a range of inductor current ripple factor. Inductor current ripple is controlled solely by changing inductance. This study concluded that all three algorithms were quite robust and affected very little over an inductor current ripple factor range of 20% to 40%. One novel finding was increased duty cycle oscillation when the MPPT update and sample speed was faster than the boost converter response.

Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a disabling chronic disease of still unknown origin and complex pathophysiology. The disease affects mainly female patients, with a female to male ratio of about 9 to 1. Prevalence ranges from 52 to 500/100,000 in females and 8 to 41/100,000 in males. The diagnosis of IC/BPS is mainly hampered by the lack of appropriate biomarkers and, therefore, extensive clinical examinations are required to exclude “confusable” diseases [1]. In consequence, most patients experience several years of ineffective treatments of various urinary tract symptoms often associated with, but by themselves not characteristic of, IC/BPS. Unequivocal diagnosis of IC/BPS is the prerequisite to find more effective therapeutic approaches. Therefore, more specific biomarkers are needed to facilitate IC/BPS diagnosis and to stratify patients for treatment at earlier stages of the disease. In this Special Issue, we gathered reviews and original work elucidating the current developments in IC/BPS biomarker research.

This study examines the intellectual capital (IC) disclosure practices in the annual reports of 100 listed UK firms selected from sectors considered to be IC-intensive. It also investigates the possible determinants of such disclosure practices from the three perspectives of corporate governance structure, company characteristics and market factors. IC disclosures were captured using content analysis, and were measured by a disclosure index, supported by word count and percentage of word count metrics to assess the variety, volume and focus of IC disclosure respectively, at both overall and subcategory levels. The presentational formats and locations of IC disclosures were also recorded. The results indicate that the UK firms sampled provide considerable IC information in their annual reports, mainly in text form, with popular use of numerical information, while the use of graphs and pictures for many IC elements remains low. The distribution of IC disclosures, captured in three categories, varies by the three measures of disclosure applied. IC information was found in virtually all sections of the annual report and was most concentrated in the Operating and Financial Review section. IC terms typically used in the academic literature do not feature in the sampled annual reports. The results of the statistical analyses based on the three measures of IC disclosure indicate significant associations with a number of corporate governance factors (i.e. board composition, share concentration, audit committee size and frequency of meeting, board directors¿ shareholding, audit committee directors¿ shareholding, and board directors with cross-directorships), company characteristics (i.e. firm size, profitability, and listing age), and market factors (i.e. `hidden value¿, share price volatility, share turnover, and multiple listing). These findings offer support for a number of theories, such as information asymmetry, agency and signalling theory. The influence of these explanatory factors on human, structural and relational capital disclosures, based on all three disclosure measure metrics, as well as on the format of IC disclosure, was also explored. The study also finds that its IC framework is more effective than a less detailed framework used in prior studies for the purpose of examining IC disclosure practice and its determinants. The study contributes to the further advancement of the state of knowledge in relation to IC disclosure both empirically and methodologically. It provides information users, preparers, regulatory bodies and academics with a state-of-the-art understanding of IC disclosure practices in the annual report. The transparent content analysis process enables future replication and comparison of results. The rigorous measurements of IC disclosure, the greater specificity of disclosure about the location and presentational format, and the more detailed IC research framework can be usefully applied by other studies. By examining the relationship between explanatory factors and IC disclosure, it helps shareholders and other groups of information users as well as the regulatory bodies to identify factors that may encourage IC disclosure in the annual report.

After undergoing a study about current engine modelling and mapping approaches as well as the engine modelling requirements for different applications, a major problem found to be present is the extensive and time consuming mapping procedure that every engine has to go through so that all control parameters can be derived from experimental data. To improve this, a cycle-by-cycle modelling approach has been chosen to mathematically represent reciprocating engines starting by a complete dynamics crankshaft mechanism model which forms the base of the complete engine model. This system is modelled taking into account the possibility of a piston pin offset on the mechanism. The derived Valvetrain model is capable of representing a variable valve lift and phasing Valvetrain which can be used while modelling most modern engines. A butterfly type throttle area model is derived as well as its rate of change which is believed to be a key variable for transient engine control. In addition, an approximation throttle model is formulated aiming at real-time applications. Furthermore, the engine inertia is presented as a mathematical model able to be used for any engine. A spark ignition engine simulation (SIES) framework was developed in MATLAB SIMULINK to form the base of a complete high fidelity cycle-by-cycle simulation model with its major target to provide an environment for virtual engine mapping procedures. Some experimental measurements from an actual engine are still required to parameterise the model, which is the reason an engine mapping (EngMap) framework has been developed in LabVIEW, It is shown that all the moving engine components can be represented by a single cyclic variable which can be used for flow model development.

No description available.