La tasa de nacimientos prematuros en 184 países afiliados a la OMS va de 5 a 18%, por eso, en las metas ampliadas, estableció que deberá reducirse la tasa de mortalidad neonatal por parto prematuro en 50% en el periodo 2010-2025 en los países con tasa ≥ 5 x 1,000 nacidos vivos, lo que evitaría que 550,000 prematuros mueran cada año para el 2025. La recomendación principal de la OMS para evitar la muerte neonatal es: la aplicación del Método mamá Canguro, es por ello que se realizó el trabajo de investigación titulado: “Experiencias de las enfermeras frente a la aplicación del método mamá canguro en recién nacidos prematuros en un hospital local, Chiclayo, 2021”; con el objetivo de describir, analizar y comprender las experiencias de las enfermeras frente a la aplicación del método mamá canguro. La investigación fue de tipo cualitativo, con metodología descriptiva. Los sujetos de estudio fueron las enfermeras del servicio de neonatología; el tamaño de la muestra se determinó con la técnica de saturación; los datos se obtuvieron mediante la entrevista semiestructurada. Se obtuvo como resultado 3 categorías: Beneficios del método mamá canguro, experiencias afectivas ante la aplicación del método mamá canguro, e inexperiencia y temor del método mamá canguro ante un hijo prematuro. Conclusión: Las enfermeras, experimentan sentimientos muy profundos al ver a las madres realizar éste método, asimismo se confirma que uno de los beneficios del método mamá canguro es la mejora del desarrollo del niño prematuro de una forma muy rápida y eficaz. / The rate of premature births in 184 countries affiliated with the WHO ranges from 5 to 18%, therefore, in the expanded goals, it was established that the neonatal mortality rate due to premature birth should be reduced by 50% in the period 2010-2025 in the countries with a rate ≥ 5 x 1,000 live births, which would prevent 550,000 premature babies from dying each year by 2025. The main recommendation of the WHO to avoid neonatal death is: the application of the Kangaroo Mother Method, which is why the research work titled: “Nurses' experiences regarding the application of the kangaroo mother method in premature newborns in a local hospital, Chiclayo, 2021”; with the objective of describing, analyzing and understanding the experiences of nurses regarding the application of the kangaroo mother method. The research was qualitative, with descriptive methodology. The study subjects were the nurses of the neonatology service; the sample size was determined with the saturation technique; The data were obtained through the semi-structured interview. The result was 3 categories: Benefits of the kangaroo mother method, affective experiences with the application of the kangaroo mother method, and inexperience and fear of the kangaroo mother method when faced with a premature child. Conclusion: Nurses experience very deep feelings when seeing mothers perform this method. It is also confirmed that one of the benefits of the kangaroo mother method is the improvement of the development of premature children in a very fast and effective way.

Bakgrund: Känguruvård är en typ av vård som används hos för tidigt födda eller sjuka barn. Metoden utgörs av tre delar: förlängd hud-mot-hud-kontakt, strävan efter exklusivt födointag av bröstmjölk samt strävan efter en tidig hemgång eller förflyttning till lägre vårdnivå. Kängurumetoden har visat sig ha många positiva effekter varpå metoden idag är rekommenderad att initieras en timme efter födseln. Föräldrarna har en viktig roll i känguruvården vilket gör det relevant att undersöka deras upplevelser av behandlingsmetoden för att den ska kunna optimeras.  Syfte: Syftet var att undersöka föräldrars upplevelser av att vårda sitt barn med känguruvård på neonatalavdelningar. Metod: Kvalitativ, deskriptiv litteraturstudie. Tio artiklar inkluderades i resultatet. Huvudresultat: Resultatet från litteraturstudien delades in i två huvudkategorier; (i) barriärer för att utföra känguruvård och (ii) emotionella upplevelser. Resultatet var övervägande positivt där föräldrarna upplevde ett ökat självförtroende, en märkbar trygghet hos barnet samt en ökad anknytning mellan barn och förälder. Även barriärer för att utföra känguruvården framkom. Dessa utgjordes av sjukhusmiljön, personalens attityder, livet utanför samt hälsan hos mamman.  Slutsats: Föräldrarnas upplevelser av känguruvård var övervägande positiva där de beskrev att behandlingsmetoden var något som stärkte dem emotionellt. Det framkom dock även hinder i samband med utförandet av känguruvård vilket innebär att en utvecklingspotential för behandlingsmetoden finns. I sjukvården och som sjuksköterska är det därför viktigt att lyssna på föräldrarnas upplevelser och åsikter för att uppnå en positiv utveckling inom känguruvården.  Nyckelord: Känguruvård, föräldrar, upplevelser, prematur, hud-mot-hud. / Background: Kangaroo mother care is a method used for premature or sick children. The method contains three parts: extended skin-to-skin contact, an aim for exclusive food intake of breast milk, as well as an aspiration for an early departure home or a transfer to a lower level of care. The kangaroo mother care has indicated several positive effects and is therefore currently recommended to be initiated within an hour post labor. The parents play a crucial part in the kangaroo mother care making it relevant to examine their experiences of the method of treatment to enable optimization of it.  Aim: The aim was to examine the parental experiences by caring for their newborn children with kangaroo mother care in the neonatal intensive care unit. Method: Qualitative, descriptive literature study. Ten articles were included in the result. Main findings: The result from the literature study were divided into two main categories; (i) barriers to execute kangaroo mother care and (ii) emotional experiences. The result was predominantly positive as the parents experienced an increased self-esteem, a noticeable sense of security of the child and an increased attachment bond between child and parent. Barriers to perform kangaroo mother care also emerged. These were constituted by the hospital environment, the attitude of staff, life outside the hospital and the mother’s health. Conclusion: The parental experiences of kangaroo mother care were predominantly positive as they expressed a feeling of an increased emotional strength due to the method of treatment. However, barriers to execute kangaroo mother care were also presented which indicates a potential for further development of the method. Within health care and as a nurse it is therefore important to listen to parents voicing their experiences and opinions in order to achieve a positive development of kangaroo mother care.  Keywords: Kangaroo care, parents, experiences, premature, skin-to-skin.

Thesis (MSc)--University of Stellenbosch, 2005. / ENGLISH ABSTRACT: This study investigated the composition of Themeda triandra Renosterveld in part of the Grootvadersbosch Conservancy and the effects of selected environmental and management variables to provide guidelines for promoting the presence of Themeda triandra in the veld. The Zürich-Montpellier phytosociological method was used to determine the composition of the Renosterveld communities. The point quadrat method was used to determine the cover of Themeda triandra at three grass dominated sites and compare cover from one site with past cover measurements at the specific site. Ordination was used to examine the effects of the environmental and management variables on the plant communities. Two community groups, five communities and five subcommunities were identified and described. The Themeda triandra – Stoebe phyllostachys Grassland Community Group consists of two communities of which one has two subcommunities. The Themeda triandra – Elytropappus rhinocerotis Shrubland Community Group consists of three communities of which one has three subcommunities. The vegetation units described in this study have not been described previously in the literature. One community belongs to Silcrete Fynbos while another subcommunity is transitional between Renosterveld and thicket and gallery forest. The rest of the plant communities fit the definition for Renosterveld (the local Renosterveld type is Eastern Rûens Shale Renosterveld). Cover of Themeda triandra did not differ significantly either between sites or between years. The comparison of Themeda triandra cover between years was done at a site that had been burnt between the last two sampling times yet the cover was not significantly different. This indicates that fire and other management practices did not have a negative impact on Themeda triandra at the site. Unconstrained ordination of the dataset in which cover/abundance values were included, grouped the relevés by moisture and disturbance but the presence/absence dataset indicates that the two community groups have a slight transitional overlap. Constrained ordination of both datasets with a) soil variables and b) management variables, both showed a tendency to separate the relevés into community groups, that did not happen with topographic and vegetation variables. Ordination did not separate the community groups into their subdivisions. The soil variables (both nutrients and texture) influence the vegetation structure and the community distribution. Under the existing grazing management regime, fire at three to five year intervals promoted the dominance of Themeda triandra by affecting the structure of the plant communities, the abundance of species other than Themeda triandra, and influencing which plant community is present. The use of fire as a management tool was regulated by the importance of the natural veld pastures to the farmers. The natural veld pastures are not suitable for dairy cattle in milk. Thus dairy farmers are less likely to burn the natural veld (no planned burns only chance fires) than those who farm with mutton or beef (planned burns on a three to five year interval). / AFRIKAANSE OPSOMMING: Die studie het die samestelling van Themeda triandra Renosterveld in ’n deel van die Grootvadersbosch-Bewaria en die uitwerking van geselekteerde omgewings- en bestuursveranderlikes ondersoek om riglyne vir die bevordering van Themeda triandra in die veld daar te stel. Die Zürich-Montpellier fitososiologiese metode is gebruik om die samestelling van die Renosterveldgemeenskappe te bepaal. Die puntkwadraat-metode is gebruik om ’n skatting van die dekking van Themeda triandra by drie gras-gedomineerde persele te bepaal en om ’n vergelyking te maak tussen die huidige en vorige dekking van ’n enkele perseel. Ordinasie is gebruik om die invloed van omgewings- en bestuursveranderlikes op die plantgemeenskappe te bepaal. Twee gemeenskapsgroepe, vyf gemeenskappe en vyf subgemeenskappe is geïdentifiseer en gedefinieer. Die Themeda triandra – Stoebe phyllostachys Grasland-gemeenskapsgroep bestaan uit twee gemeenskappe waarvan een in twee subgemeenskappe onderverdeel is. Die Themeda triandra – Elytropappus rhinocerotis Struik-gemeenskapsgroep bestaan uit drie gemeenskappe waarvan een in drie subgemeenskappe onderverdeel is. Die plantegroei-eenhede wat in die studie beskryf is, is nie voorheen in die literatuur beskryf nie. Een gemeenskap behoort aan Silkreet-fynbos en ’n ander subgemeenskap is ’n oorgangsfase tussen Renosterveld en struikbosveld of woud, terwyl die res van die plantgemeenskappe binne die definisie van Renosterveld val (die plaaslike Renosterveld tipe staan bekend as Oostelike Rûens Skalierenosterveld). Die bedekking van Themeda triandra het nie betekenisvol gevarieer tussen óf die verskillende lokaliteite óf die verskillende jare nie. Die vergelyking van Themeda triandra-bedekking oor tyd is onderneem in ’n gebied wat tussen opnames gebrand is. Die bedekking het nie betekenisvol verskil nie. Dit dui aan dat vuur en ander bestuurspraktyke nie ’n negatiewe invloed op Themeda triandra in hierdie gebied het nie. Onbeperkte ordinasie van die datastel met die vergelyking van bedekking/volopheidwaardes, groepeer die relevés volgens vogtigheid en versteuring, terwyl die datastel ten opsigte van teenwoordigheid/ afwesigheid aandui dat die twee gemeenskapsgroepe ’n effense oorgangs-oorvleueling het. Beperkte ordinasie van beide datastelle met a) grondveranderlikes en b) bestuursveranderlikes, toon albei ’n neiging om die gemeenskapsgroepe te skei, wat nie gebeur het met die topografiese- en plantegroeiveranderlikes nie. Ordinasie het nie die gemeenskapsgroepe onderverdeel in gemeenskappe of subgemeenskappe nie. Die grondveranderlikes (beide voedingstowwe en tekstuur) beïnvloed die struktuur en die verspreiding van die plantegroei. Met die bestaande weidingsbestuur bevorder brande met ’n interval van tussen drie tot vyf jaar die oorheersing van Themeda triandra deur die struktuur van die teenwoordige plantgemeenskap te beïnvloed, deur die getal van die verskillende plantsoorte te beïnvloed en selfs deur die plantgemeenskap se voorkoms te beïnvloed. Die waarde wat die boer aan die natuurlike veld as weiveld heg bepaal die mate waartoe hulle veldbrand gebruik as ’n deel van bestuur. Die natuurlike veld is nie geskik vir melkkoeie wat in die melkproduksiestadium is nie. Die melkboere is dus minder geneig om die natuurlike veld te brand (geen beplande brande nie net kans brande) as die boere wat met vleisbeeste of skape boer (beplande brande elke drie tot vyf jaar).

Introdução: O controle da dor em recém-nascidos (RN) é necessário, tendo em vista que a exposição contínua e repetitiva à dor poderá trazer consequências ao desenvolvimento da criança. Há evidências consistentes sobre o efeito analgésico e segurança de se administrar a oferta oral de soluções adocicadas em RN submetidos a procedimentos dolorosos agudos. A amamentação e o contato pele a pele são práticas rotineiras, de baixo custo e incentivadas pelo Programa Hospital Amigo da Criança, com evidência de efetividade analgésica que pode ser adotada, como medida alternativa à oferta de soluções adocicadas. Entretanto, é preciso avaliar se seu efeito analgésico e sua segurança superam a solução adocicada na administração de vacinas, antes de recomendar sua adoção. Hipótese: O efeito analgésico combinado da amamentação com o contato pele a pele é superior à oferta oral de glicose 25% na administração da vacina BCG em RN. Objetivo: Avaliar o efeito analgésico da combinação da amamentação com contato pele a pele na administração da vacina BCG em RN a termo. Método: Ensaio clínico randomizado, conduzido em um hospital de ensino da cidade de São Paulo, certificado como Hospital Amigo da Criança. A amostra foi composta por 109 RN a termo, saudáveis, internados na Unidade de Alojamento Conjunto do HU, entre agosto e setembro de 2015. A amostra foi randomizada e os RN alocados nos Grupos Experimental (GE amamentação + contato pele a pele iniciada 5 minutos, antes da administração da vacina de BCG) e Controle (oferta oral de 2 ml de solução glicosada 25% ao RN posicionado verticalmente no colo materno, 2 minutos, antes da administração da vacina de BCG). O desfecho primário analisado foi o escore de dor obtido com a avaliação pela escala Premature Infant Pain Profile- Revised (PIPP-R). O escore de dor foi obtido em seis intervalos de 30 segundos (30, 60, 90, 120, 150 e 180 segundos) pós-administração da vacina. Os desfechos secundários avaliados foram os indicadores fisiológicos frequência cardíaca (FC) e saturação de oxigênio (SatO2), além de alterações na mímica facial - sobrancelhas salientes, olhos espremidos e sulco nasolabial, duração do choro e eventos adversos. Os dados foram obtidos por meio de filmagens do recém-nascido para captar a mímica facial e do display do monitor multiparamétrico com os registros da FC e SatO2. Os dados foram extraídos por meio da análise segundo a segundo das filmagens e foram registrados em formulário impresso próprio e, posteriormente, armazenados em planilha Microsoft Excel. A análise estatística foi processada no programa do pacote estatístico SPSS 20. Para analisar a homogeneidade da amostra, foram utilizados os testes Qui-quadrado ou Exato de Fisher para variáveis qualitativas e o teste t pareado para comparar as médias das variáveis quantitativas. Os dados das variáveis quantitativas das medidas repetidas, como FC e SatO2, foram analisados com o Modelo de Análise Misto, e as medidas repetidas de escores de PIPP-R analisadas pelo modelo ANOVA (Modelo Geral Linear). O projeto de pesquisa foi aprovado pelos Comitês de Ética da Escola de Enfermagem e do Hospital Universitário da Universidade de São Paulo e registrado no Registro Brasileiro de Ensaios Clínicos. Resultados: A distribuição das variáveis sexo, gemelaridade, tipo de parto, Apgar, peso, idade gestacional, número de procedimentos dolorosos anteriores e tempo desde a última mamada apresentaram distribuições homogêneas entre os grupos experimental e controle. Os escores de dor foram inferiores no GE (p=0,002). Não houve diferenças estatisticamente significantes em relação ao tempo de choro (p=0,745) e ocorrência de eventos adversos (p= 0,618). Conclusão: A combinação da amamentação no contato pele a pele apresentou efeito analgésico superior à oferta oral de glicose 25% com o RN no colo materno, como resposta dolorosa do RN à vacina de BCG e que apresenta segurança para ser indicada, como intervenção analgésica na prática clínica. / Introduction: Pain management in infant newborns is necessary, given the continuous and repeated exposure to pain can have negative consequences for the child\'s development. There is robust evidence of the analgesic effect and safety of administering oral sweetened solutions to newborns undergoing acute painful procedures. Breastfeeding and the skin-to-skin care are routine clinical practices, with low cost, and the Baby-Friendly Hospital Initiative recommends them. There is evidence of both practices regarding their analgesic effectiveness, which can be adopted as an alternative treatment to sweetened solutions. However, it is necessary to assess whether the analgesic effect and safety of these measures outweigh sweetened solutions in the administration of vaccines, before recommending its adoption. Hypothesis: The analgesic effect of combining breastfeeding plus skin-to-skin contact is superior to the taste of 25% glucose in the BCG vaccination in infant newborns. Objective: To evaluate the analgesic effect of combining breastfeeding plus skin-to-skin contact in the BCG vaccination in term infant newborns. Methods: A randomized clinical trial conducted at the University of São Paulo Teaching Hospital certified as a Baby-Friendly Hospital from August to September 2015. This study was performed on 109 healthy term infants who were born during the study, admitted at a rooming-in ward. The sample was randomized and infants were allocated in Experimental Group (GE breastfeeding plus skin-to-skin contact which begun 5 minutes prior to the administration of BCG vaccine) or Control Group (CG taste of 2 mL 25% glucose administered 2 minutes prior the BCG vaccination with the mother holding her baby upright on her lap). The primary outcome analyzed was the pain score assessed by the Premature Infant Pain Profile - Revised (PIPP-R). The pain score was assessed in six intervals of 30 seconds (30th, 60th, 90th, 120th, 150th and 180th) after the BCG vaccine administration. The secondary outcomes were: physiological parameters heart rate (HR) and oxygen saturation (O2Sat), and changes in facial expression brow bulging, eyes squeezed and nasolabial furrow, crying duration and adverse events. Data was obtained from video records of the newborn facial expressions and HR and O2Sat of multiparametric monitor display. Data was extracted from the video records after being analyzed throughout every second. Data was stored in the Microsoft Excel spreadsheet. Statistical analysis was performed by statistical package SPSS 20. To analyze the homogeneity of the sample, chi-square test or Fisher\'s exact was performed for qualitative variables, to compare the means of quantitative variables, paired t-test was used. Quantitative variables of repeated measures, as HR and O2Sat were analyzed with Mixed Model Analysis and repeated measurements of PIPP-R scores were analyzed by ANOVA (General Linear Model). The ethics committee of the School of Nursing and University Hospital, both from the University of São Paulo, approved the research project. The research project is registered at the Brazilian Registry of Clinical Trials. Results: The distribution of gender, twin pregnancy, mode of delivery, Apgar, weight, gestational age, number of previous painful procedures and time since last feeding showed homogeneous distribution between the Experimental and Control groups. Pain scores were lower in the EG (p = 0.002). There were no statistically significant differences in relation to the crying duration (p = 0.745) and adverse events (p = 0.618). Conclusion: The combination of breastfeeding plus skin-to-skin contact showed superior analgesic effect regarding the comparative intervention of oral 25% glucose with infant positioned vertically in mothers lap and it is safe to be prescribed as an analgesic treatment in clinical practice.

O canguru é efetivo no alívio da dor aguda em prematuros, porém pouco se sabe sobre o papel da mãe na regulação da dor e estresse neonatal. Tem-se como objetivo geral investigar a associação entre os fatores maternos (comportamento, estado emocional e humor e estresse) e a resposta à dor e ao estresse de prematuros submetidos à punção de calcâneo para exame de triagem neonatal em posição canguru. Trata-se de experimento não-controlado, realizado na unidade neonatal de um hospital universitário de Ribeirão Preto-SP. Participaram do estudo 42 mães e seus filhos prematuros, após obtenção de consentimento livre e esclarecido. Os dados foram coletados em três fases: basal - FP (10 minutos), procedimento - FP (coleta do exame) e recuperação - FR (10 minutos). Coletaram-se amostras de saliva da mãe e do prematuro antes e após o exame doloroso e da mãe à noite e ao despertar. Mensuraram-se as variáveis: mímica facial (Neonatal Facial Coding System - NFCS), sono e vigília, duração do choro e frequência cardíaca (FC) neonatal, comportamento materno e interação mãe-filho (Maternal Mood Infant Pain Behavior Coding System), estado emocional e de humor materno (Inventários de Depressão e de Ansiedade de Beck). Explorou-se a relação entre as variáveis maternas e neonatais (análise bivariada), a influência do estado emocional e humor materno nas variáveis neonatais (análises de variância com medidas repetidas) e quais variáveis explanatórias maternas interferem nas variáveis de resposta neonatais (regressão múltipla). O escore médio do NFCS, a porcentagem de duração do tempo de choro e a FC média não alteraram significativamente entre as fases da coleta, ao controlar-se a porcentagem de duração dos estados de sono e vigília basal. As concentrações médias de cortisol salivar neonatal e materno pós-punção em relação a pré-punção não diferiram estatisticamente (p=0,731; p=1,000, respectivamente). Encontrou-se associação entre o escore médio do NFCS na FP e a concentração de cortisol salivar pré-punção materno (r=0,32; p=0,040); a porcentagem tempo do choro na FP e a concentração de cortisol salivar pré-punção materno (r=-0,32; p=0,047); a FC neonatal na FP e as concentrações de cortisol salivar noturno (r=-0,49; p=0,002), pré-punção (r=-0,34; p=0,025) e pós-punção (r=-0,51; p=0,001) materna; a FC neonatal na FR e as concentrações de cortisol salivar noturno (r=-0,45; p=0,004), prépunção (r=-0,41; p=0,007) e pós-punção (r=-0,50; p=0,001), as concentrações de cortisol salivar pré-punção neonatal e noturno materno (r=0,39; p=0,016) e as concentrações do cortisol pós-punção neonatal e materno (r=0,34; p=0,027). A presença de sintomas de ansiedade e depressão e o comportamento maternos não influenciaram a resposta de dor e estresse do prematuro. A concentração do cortisol salivar materno pré-punção foi preditor da variância da concentração do cortisol salivar pós-punção do prematuro [coeficiente R2 ajustado=0,092; F(1,36)=4,764; p=0,036]; a concentração de cortisol salivar noturno materno, juntamente com a idade pós-natal do prematuro, explicaram a variância da FC neonatal [coeficiente R2 ajustado=0,282; F(2,35)=8,219; p=0,001]. Concluiu-se que a capacidade das mães participantes do estudo em regular o seu próprio estresse pode contribuir para a resposta de dor e estresse do prematuro. Outros estudos são necessários para fortalecer as evidências. / Maternal kangaroo care (MKC) effectively reduces acute pain and stress in the preterm, but very little is known about the maternal role during MKC. The main purpose of the present non-controlled intervention study was to examine relationships between maternal factors (caregiving behaviour, depression and anxiety and maternal own stress) and preterm infant pain and stress response during heel lance (HL) for routine neonatal blood screening while in MKC. The study was carried out in a neonatal unit at a university hospital in Ribeirao Preto- SP and involved 42 consenting mothers and their stable preterm infants. Maternal and infant data were collected during three study phases: Baseline (10 minutes - before HL), HL procedure (during blood collection) and Recovery (10 minutes - post HL). On the day of the infant\'s scheduled HL, maternal and infant salivary cortisol samples were collected at baseline and 20 minutes post-HL. Two additional maternal salivary cortisol samples were collected (night and awakening). Continuous measures of infant heart rate (HR) were collected and maternal caregiving behaviour and infant pain behaviour (facial action, cry and infant state) were continuously videotaped during the three study phases. Within the following week of each infant\'s HL, the emotional state of study mothers was assessed using the Beck Depression and Anxiety Inventories. The Neonatal Facial Coding System (NFCS) and the Maternal Mood Infant Pain Behaviour Coding System were used to code infant and maternal behaviour, second-by-second, from which time based measures of behaviour were generated. Relationships between maternal and neonatal measures were initially analyzed using bivariate analyses and RM-ANOVA was used to examine change in maternal and infant measures. Multiple regression analyses were then used to test which maternal variables predicted neonatal responses. No statistical significant differences in infant mean NFCS score, cry percentage duration and HR were observed across the study phases when baseline percentage duration of infant sleep-awake state was controlled. Also, maternal and neonatal salivary cortisol pre-HL and post-HL did not differ statistically (p=0.731; p=1.000, respectively). However, mean NFCS score and percentage duration of infant cry during the HL procedure were found to be associated with maternal pre-HL salivary cortisol level (r=0.32; p=0.040 and r=-0.32; p=0.047, respectively). Associations were also observed between neonatal HR duration and maternal nocturne (r=-0.49; p=0.002), pre-HL (r=-0.34; p=0.025) and post-HL (r=-0.51; p=0.001) salivary cortisol levels. Further, neonatal HR post HL procedure was related with nocturne (r=-0.45; p=0.004), pre-HL (r=-0.41; p=0.007) and post-HL (r=-0.50; p=0.001) maternal salivary cortisol. In this study, maternal scores of depression and anxiety and percentage of time spent expressing typical and typically depressed behaviour were not found to predict preterm pain and stress response. However, mother salivary cortisol level pre-HL predicted preterm salivary cortisol post-HL [adjusted R2=0.092; F(1,36)=4.764; p=0.036]; and maternal nocturne salivary cortisol together with gestational age predicted neonatal HR [adjusted R2=0.282; F(2,35)=8.219; p=0.001]. Study findings support the effectiveness of the maternal regulatory role in MKC but do suggest that the stress regulatory ability (as reflected by maternal cortisol levels) of the studies mothers may be predictive of alteration in pain and stress response in preterm offspring. Similar studies are needed to substantiate and to build on study findings.

Introdução: O controle da dor em recém-nascidos (RN) é necessário, tendo em vista que a exposição contínua e repetitiva à dor poderá trazer consequências ao desenvolvimento da criança. Há evidências consistentes sobre o efeito analgésico e segurança de se administrar a oferta oral de soluções adocicadas em RN submetidos a procedimentos dolorosos agudos. A amamentação e o contato pele a pele são práticas rotineiras, de baixo custo e incentivadas pelo Programa Hospital Amigo da Criança, com evidência de efetividade analgésica que pode ser adotada, como medida alternativa à oferta de soluções adocicadas. Entretanto, é preciso avaliar se seu efeito analgésico e sua segurança superam a solução adocicada na administração de vacinas, antes de recomendar sua adoção. Hipótese: O efeito analgésico combinado da amamentação com o contato pele a pele é superior à oferta oral de glicose 25% na administração da vacina BCG em RN. Objetivo: Avaliar o efeito analgésico da combinação da amamentação com contato pele a pele na administração da vacina BCG em RN a termo. Método: Ensaio clínico randomizado, conduzido em um hospital de ensino da cidade de São Paulo, certificado como Hospital Amigo da Criança. A amostra foi composta por 109 RN a termo, saudáveis, internados na Unidade de Alojamento Conjunto do HU, entre agosto e setembro de 2015. A amostra foi randomizada e os RN alocados nos Grupos Experimental (GE amamentação + contato pele a pele iniciada 5 minutos, antes da administração da vacina de BCG) e Controle (oferta oral de 2 ml de solução glicosada 25% ao RN posicionado verticalmente no colo materno, 2 minutos, antes da administração da vacina de BCG). O desfecho primário analisado foi o escore de dor obtido com a avaliação pela escala Premature Infant Pain Profile- Revised (PIPP-R). O escore de dor foi obtido em seis intervalos de 30 segundos (30, 60, 90, 120, 150 e 180 segundos) pós-administração da vacina. Os desfechos secundários avaliados foram os indicadores fisiológicos frequência cardíaca (FC) e saturação de oxigênio (SatO2), além de alterações na mímica facial - sobrancelhas salientes, olhos espremidos e sulco nasolabial, duração do choro e eventos adversos. Os dados foram obtidos por meio de filmagens do recém-nascido para captar a mímica facial e do display do monitor multiparamétrico com os registros da FC e SatO2. Os dados foram extraídos por meio da análise segundo a segundo das filmagens e foram registrados em formulário impresso próprio e, posteriormente, armazenados em planilha Microsoft Excel. A análise estatística foi processada no programa do pacote estatístico SPSS 20. Para analisar a homogeneidade da amostra, foram utilizados os testes Qui-quadrado ou Exato de Fisher para variáveis qualitativas e o teste t pareado para comparar as médias das variáveis quantitativas. Os dados das variáveis quantitativas das medidas repetidas, como FC e SatO2, foram analisados com o Modelo de Análise Misto, e as medidas repetidas de escores de PIPP-R analisadas pelo modelo ANOVA (Modelo Geral Linear). O projeto de pesquisa foi aprovado pelos Comitês de Ética da Escola de Enfermagem e do Hospital Universitário da Universidade de São Paulo e registrado no Registro Brasileiro de Ensaios Clínicos. Resultados: A distribuição das variáveis sexo, gemelaridade, tipo de parto, Apgar, peso, idade gestacional, número de procedimentos dolorosos anteriores e tempo desde a última mamada apresentaram distribuições homogêneas entre os grupos experimental e controle. Os escores de dor foram inferiores no GE (p=0,002). Não houve diferenças estatisticamente significantes em relação ao tempo de choro (p=0,745) e ocorrência de eventos adversos (p= 0,618). Conclusão: A combinação da amamentação no contato pele a pele apresentou efeito analgésico superior à oferta oral de glicose 25% com o RN no colo materno, como resposta dolorosa do RN à vacina de BCG e que apresenta segurança para ser indicada, como intervenção analgésica na prática clínica. / Introduction: Pain management in infant newborns is necessary, given the continuous and repeated exposure to pain can have negative consequences for the child\'s development. There is robust evidence of the analgesic effect and safety of administering oral sweetened solutions to newborns undergoing acute painful procedures. Breastfeeding and the skin-to-skin care are routine clinical practices, with low cost, and the Baby-Friendly Hospital Initiative recommends them. There is evidence of both practices regarding their analgesic effectiveness, which can be adopted as an alternative treatment to sweetened solutions. However, it is necessary to assess whether the analgesic effect and safety of these measures outweigh sweetened solutions in the administration of vaccines, before recommending its adoption. Hypothesis: The analgesic effect of combining breastfeeding plus skin-to-skin contact is superior to the taste of 25% glucose in the BCG vaccination in infant newborns. Objective: To evaluate the analgesic effect of combining breastfeeding plus skin-to-skin contact in the BCG vaccination in term infant newborns. Methods: A randomized clinical trial conducted at the University of São Paulo Teaching Hospital certified as a Baby-Friendly Hospital from August to September 2015. This study was performed on 109 healthy term infants who were born during the study, admitted at a rooming-in ward. The sample was randomized and infants were allocated in Experimental Group (GE breastfeeding plus skin-to-skin contact which begun 5 minutes prior to the administration of BCG vaccine) or Control Group (CG taste of 2 mL 25% glucose administered 2 minutes prior the BCG vaccination with the mother holding her baby upright on her lap). The primary outcome analyzed was the pain score assessed by the Premature Infant Pain Profile - Revised (PIPP-R). The pain score was assessed in six intervals of 30 seconds (30th, 60th, 90th, 120th, 150th and 180th) after the BCG vaccine administration. The secondary outcomes were: physiological parameters heart rate (HR) and oxygen saturation (O2Sat), and changes in facial expression brow bulging, eyes squeezed and nasolabial furrow, crying duration and adverse events. Data was obtained from video records of the newborn facial expressions and HR and O2Sat of multiparametric monitor display. Data was extracted from the video records after being analyzed throughout every second. Data was stored in the Microsoft Excel spreadsheet. Statistical analysis was performed by statistical package SPSS 20. To analyze the homogeneity of the sample, chi-square test or Fisher\'s exact was performed for qualitative variables, to compare the means of quantitative variables, paired t-test was used. Quantitative variables of repeated measures, as HR and O2Sat were analyzed with Mixed Model Analysis and repeated measurements of PIPP-R scores were analyzed by ANOVA (General Linear Model). The ethics committee of the School of Nursing and University Hospital, both from the University of São Paulo, approved the research project. The research project is registered at the Brazilian Registry of Clinical Trials. Results: The distribution of gender, twin pregnancy, mode of delivery, Apgar, weight, gestational age, number of previous painful procedures and time since last feeding showed homogeneous distribution between the Experimental and Control groups. Pain scores were lower in the EG (p = 0.002). There were no statistically significant differences in relation to the crying duration (p = 0.745) and adverse events (p = 0.618). Conclusion: The combination of breastfeeding plus skin-to-skin contact showed superior analgesic effect regarding the comparative intervention of oral 25% glucose with infant positioned vertically in mothers lap and it is safe to be prescribed as an analgesic treatment in clinical practice.

Made available in DSpace on 2016-04-28T20:39:09Z (GMT). No. of bitstreams: 1 Ana Paula Marson.pdf: 673352 bytes, checksum: 9c50a1e9a8526b3c7e6ee5ad0a0cfb26 (MD5) Previous issue date: 2015-09-18 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / This study investigates the Kangaroo Care intervention possibilities concerning the mother's approach to her premature baby, surrounded by a technological barrier that permeates treatment. The survival and development of the baby depend on technology, medicines and health professionals, as they represent, in his early life, safety for him and his mother. In the face of the adversities of this situation, the aim of the study is to analyze the challenges of the implementation of the 1st phase of the Kangaroo Care in a neonatal unit. Kangaroo Care not only provides early skin-to-skin contact between the infant and the mother and father, allowing greater participation in caring, but also enables the organization of the neonatal environment as to noise and lighting, and pain control, in order to decrease the negative effects on the infant s development. The basis of Winnicott's thought shows that the consistency of maternal care ensures continuity of being or continuing baby's existence. Thus, the baby depends emotionally on the mother for his survival and, in the neonatal unit, depends on the professionals present there. Thus, the concern of this research is to look closer at the medical professionals who work in the neonatal unit, because the physical and mental health of the premature baby depends on them. The research was conducted at the Neonatal Unit of the University Hospital of the State University of Londrina. We used a qualitative research method, participant observation and interviews, contextualizing the first stage of the Kangaroo Care implementation through evaluation of benefits and difficulties / O presente estudo investiga as possibilidades de intervenção do Método Canguru no que diz respeito à aproximação da mãe com seu bebê prematuro, envolto em toda barreira tecnológica que permeia o tratamento. A sobrevivência e desenvolvimento do bebê dependem do maquinário, de medicamentos e de profissionais atuantes nesse contexto, visto que se tornam, no início da sua vida, a segurança para ele e para a sua mãe. Diante das adversidades que essa situação coloca, o interesse deste estudo consiste em analisar os desafios da implantação da 1ª etapa do Método Canguru em uma unidade neonatal. O Método Canguru proporciona o contato pele a pele precoce entre a mãe-bebê e o pai, permitindo uma maior participação desses no cuidado com seu bebê, como também permite toda a organização do ambiente neonatal no sentido de diminuição de ruídos, de luminosidade, controle de dor, a fim de minimizar os efeitos negativos no desenvolvimento do prematuro. A base de todo pensamento winnicottiano evidencia que a constância do cuidado materno assegura a continuidade do ser ou existência continuada do bebê. Sendo assim, o bebê depende emocionalmente da mãe para sua sobrevivência e, na unidade neonatal depende dos profissionais lá presentes. Desse modo, a preocupação desta pesquisa consiste em voltar um olhar mais atento aos personagens que participam da neonatal, pois deles dependem o seguimento da saúde física e mental do bebê prematuro. A pesquisa foi desenvolvida na Unidade Neonatal do Hospital Universitário da Universidade Estadual de Londrina. Para isso, utilizou-se do método qualitativo de pesquisa, com uso da observação participante e de entrevistas, contextualizando a primeira etapa da implantação do Método Canguru mediante avaliação de benefícios e dificuldades

CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior / A falta de conhecimento por parte das mÃes acerca da saÃde ocular dos seus filhos à um denominador comum encontrado quando sÃo abordadas sobre essa temÃtica, principalmente relacionado à estimulaÃÃo visual, componente de valor significativo na saÃde ocular dos recÃm-nascidos. Nesse intuito, objetivamos aplicar um manual com Ãnfase na estimulaÃÃo visual para mÃes de crianÃas com risco para alteraÃÃes visuais e validar material e mÃtodo para educaÃÃo e saÃde aplicado à estimulaÃÃo visual de crianÃas prematuras e/ou com riscos para alteraÃÃes visuais. A coleta de dados foi realizada de abril a junho de 2005 em trÃs momentos metodolÃgicos. No primeiro momento, o manual foi avaliado por trÃs especialistas; no segundo, foi reformulado a partir das suas sugestÃes; e no terceiro, o manual foi aplicado com as mÃes internadas na enfermaria mÃe-canguru, sendo realizadas entrevistas gravadas, as quais abordaram itens de avaliaÃÃo apÃs a leitura do manual. Os dados foram organizados segundo Bardin (1977) e analisados conforme Nietshe (2000). As sugestÃes, de acordo com indicaÃÃo dos especialistas, contemplaram a contracapa, com a identificaÃÃo completa das autoras; acrÃscimo de um item sobre a histÃria obstÃtrica e outro sobre sinais e sintomas de alteraÃÃes visuais; modificaÃÃo de um desenho sobreposto ao texto que dificultava a leitura; Ãnfase ao tÃpico sobre a participaÃÃo dos pais na promoÃÃo à saÃde ocular dos seus filhos; atualizaÃÃo da literatura; e ampliaÃÃo do material criado para todas as crianÃas com riscos para alteraÃÃes visuais, nÃo apenas para os prematuros. Em seguida foi promovido o segundo momento, com a inserÃÃo do conteÃdo sugerido pelos especialistas. ApÃs a anÃlise temÃtica das 12 entrevistas, identificamos quatro temas, a saber: PercepÃÃo do manual, Conhecimento das mÃes acerca da saÃde ocular, Estrutura do manual e PromoÃÃo à saÃde ocular. ConcluÃmos que o manual facilitou a aprendizagem sobre a estimulaÃÃo visual, como tambÃm facilitarà a identificaÃÃo de alteraÃÃes visuais durante a convivÃncia familiar, alÃm de proporcionar incentivo à continuidade da estimulaÃÃo no domicÃlio como fator indispensÃvel para o desenvolvimento da crianÃa, seja ela prematura ou nÃo. Ao mencionar os componentes contemplados pela tecnologia emancipatÃria, como o exercÃcio da consciÃncia crÃtica, a cidadania, a liberdade e a autonomia, afirmamos que cada um deles esteve presente na aplicaÃÃo do manual, inserindo-o na prÃtica junto Ãs mÃes como tecnologia emancipatÃria. / The lack of knowledge on the part of mothers about their childrenâs ocular health is a common denominator found when they are asked about this theme, mainly concerning the visual stimulation, which is a component of significant value to the newborn babiesâ ocular health. Thus, one aimed to apply a handbook highlighting the visual stimulation for mothers of children with risk to visual alterations and to validate material and method for education and health applied to visual stimulation of premature children and/or with risks to visual alterations. Data collection was carried out from April to June, 2005 in three methodological moments. On the first moment, the handbook was analyzed by three experts, on the second one, the handbook was reformulated starting from the suggestions and on the third moment the handbook was applied to the mothers admitted to the kangaroo-mother ward, with record of interviews where the items of evaluation were approached after the reading of the handbook. The data were described according to Bardin (1977) and Nietsche(2000). Referring to the first moment, one suggested changes in the handbookâs back page, with the complete identification of the authors, addition of an item about the obstetric history and another about signs and symptoms of visual alterations; change of a drawing that was over the text making it difficult to read; emphasis on the topic about the participation of parents on the promotion of ocular health to their children; update on the literature; and enlargement of the material created for all the children with risks to visual alterations, not only the premature ones. Next, one carried out the second methodological moment, with the corrections suggested by the experts, being all obeyed. After the thematic analysis of the 12 interviews, one identified four themes: Perception of the handbook, Knowledge of mothers about ocular health, Handbookâs structure and Promotion of the ocular health. We concluded that the handbook facilitated the learning about visual stimulation, as well as it will make that the visual deficit, in case it appears, is noticed as precocious as possible, in the family life. Besides encouraging the stimulation at home as an indispensable factor to the development of the child, be it premature or not. By mentioning the components contemplated by the emancipatory technology, to know: the exercise of critical conscience, citizenship, freedom and autonomy; we affirm that each one of them was present at the application of the handbook about visual stimulation, what makes the handbook, as well as the practice together with the mothers as emancipatory technology.

O contato pele a pele e a administração oral de sacarose têm se mostrado efetivos no alívio da dor em procedimentos únicos. No entanto, há escassez de estudos que avaliam o uso do contato pele a pele em procedimentos repetidos. O objetivo geral deste estudo é comparar a efetividade do contato pele a pele em relação ao uso de sacarose 25% no alívio da dor e conforto neonatal durante duas punções de calcâneo repetidas e sucessivas, nas primeiras horas de vida. Trata-se de ensaio clínico randomizado e controlado com 40 recém-nascidos >= 36 semanas de idade gestacional e 40 mães no grupo pele a pele (3 minutos antes, durante e após a punção de calcâneo) e 40 recém-nascidos no grupo sacarose 25% (administrada 2 minutos antes da punção), todos internados no alojamento conjunto de um hospital universitário de Ribeirão Preto. Antecedendo a coleta de dados, foi assinado o Termo de Consentimento Livre e Esclarecido pelas mães participantes. Os dados foram coletados em 18 fases, divididos em duas punções de calcâneo, com nove fases cada: basal (FB), tratamento (Tto, 3º minuto do contato pele a pele e 2º minuto após a administração da sacarose), antissepsia (Anti), punção de calcâneo até 15 segundos subsequentes (T0), 15 segundos (T15), 30 segundos (T30), 60 segundos (T60), 120 segundos (T120) e 180 segundos (T180) após a punção de calcâneo. Mensuraram-se as variáveis: mímica facial, estado de sono e vigília, choro (duração e qualidade), autorregulação/autoconforto do recém-nascido e ações de conforto oferecidas pela mãe ao filho recém-nascido. Os dados foram tratados de forma descritiva, comparando-se a evolução das medidas ao longo do tempo, nos grupos de tratamento (teste Freedman), e entregrupos, em cada fase (teste de Mann- Whitney). Não houve diferença significativa (p<0,05) entre os grupos estudados quanto à frequência, duração e porcentagem média da mímica facial nas duas punções de calcâneo. Na segunda punção, o grupo pele a pele permaneceu significativamente mais tempo em sono profundo em cinco fases (Tto 2, p=0,010; T0 2, p= 0,0026; T15 2, p=0,005; T30 2, p=0,018 e T60 2, p=0,012) e o grupo sacarose em alerta ativo em três fases do procedimento (T0 2, p=0,007; T15 2, p=0,007 e T30 2, p=0,035). O choro, na segunda punção de calcâneo, esteve mais presente no grupo pele a pele em todas as fases (Tto 2, p=0,010; Anti 2, p=0,022; T0 2, p=0,004; T15 2, p=0,032; T30 2, p=0,022; T60 2, p=0,022; T120 2, p=0,022 e T180 2, p=0,022), predominando o choro forte a maior parte do tempo em ambos grupos. O grupo sacarose manifestou médias de sugar (frequência, duração e porcentagem média) significativamente maiores que o pele a pele em várias fases da coleta de dados. Acariciar e abraçar foram as ações mais frequentes manifestadas pelas mães. A frequência cardíaca não diferiu entre os grupos, exceto na fase tratamento 2 (p=0,04), sendo maior no grupo sacarose em comparação com o pele a pele. Conclui-se que o contato pele a pele é tão efetivo quanto a administração oral de sacarose 25% no alívio da dor de RN expostos a duas punções de calcâneo repetidas e sucessivas, confirmando a hipótese de estudo / Skin-to-skin contact and the oral administration of sucrose have been effective in alleviating pain in single instance procedures. There is, however, a lack of studies assessing the effect of skin-to-skin contact in repeated procedures. This study\'s general objective was to compare the effectiveness of skin-to-skin contact in comparison with 25% sucrose in alleviating pain and providing comfort to newborns during two repeated and successive heel punctures in the first hours of life. This randomized and controlled clinical trial was conducted with 40 newborns >= 36 weeks of gestational age, and 40 mothers in the skin-to-skin contact group (3 minutes before, during and after the heel puncture) and 40 newborn in the 25% sucrose group all newborn were hospitalized in rooming-in, of a university hospital in Ribeirão Preto, SP, Brazil The participant mothers signed free and informed consent forms before data collection. Data were collected in 18 phases divided into two heel punctures with nine phases each: (T0), 15 segundos (T15), 30 segundos (T30), 60 segundos baseline, treatment (Tto, the 3rd minute skin-to-skin contact and the 2nd minute after administration of sucrose), antisepsis (Anti), heel puncture until 15 following seconds (T0), 15 seconds (T15), 30 seconds (T30), 60 seconds (T60), 120 seconds (T120) and 180 seconds (T180) after heel puncture. The following variables were measured: facial movements; sleep and wakefulness state; crying (duration and quality); newborn\'s self-regulation; and comfort provided by the mother to the newborn. Data were presented in descriptive form comparing the progression of measures over time in the treatment groups (Freedman test) and between groups in each phase (Mann-Whitney test), duration and average percentage of facial movements for the two heel punctures. In the second puncture, the skin-to-skin group remained a significantly longer time in deep sleep in five phases (Tto 2, p=0.010; T0 2, p= 0.0026; T15 2, p=0.005; T30 2, p=0.018 and T60 2, p=0.012), while the sucrose group remained in active alertness in three phases of the procedure (T0 2, p=0.007; T15 2, p=0.007 and T30 2, p=0.035). In the second puncture, crying was more frequently observed in the skin-to-skin group in all the phases (Tto 2, p=0.010; Anti 2, p=0.022; T0 2, p=0.004; T15 2, p=0.032; T30 2, p=0.022; T60 2, p=0.022; T120 2, p=0.022 and T180 2, p=0.022), while strong crying predominated in most instances in both groups. The sucrose group manifested sugar means (frequency, duration and average percentage) significantly higher than the skin-to-skin group in various phases of data collection. Caressing and hugging were the most frequent actions observed among the mothers. Heart rate did not differ between groups, except for treatment phase 2 (p=0.04), which was higher among the sucrose group in comparison to the skin-to-skin group. The conclusion is that skin-to-skin contact is as effective as orally administering 25% sucrose in alleviating pain in newborns exposed to two repeated and successive heel punctures, confirming the study\'s hypothesis

"Adelaide, Dec. 1959." / Includes bibliographical references. / 1 v. (various pagings) : / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / The studies included in this thesis have been carried out since 1946 in the Department of Botany, University of Adelaide. The 25 papers, reprints from various journals, have been grouped in two sections; firstly those on intertidal ecology; secondly taxonomic studies (in order of publication). One paper on a freshwater Charophyte is also included. / Thesis (D.Sc.)--University of Adelaide, Dept. of Botany, 1959