L'attractivité des territoires vis-à-vis des investissements directs étrangers constitue, avec l'ouverture accrue des espaces économiques et politiques, un élément clé de l'intensification des flux d'échanges et d'investissements.Pour tous les pays et, plus particulièrement, pour ceux ne disposant pas d'un marché national important, l'établissement d'un diagnostic d'attractivité et la détermination d'axes prioritaires de développement constituent une démarche fondamentale applicable particulièrement à l'exemple du Luxembourg, une économie considérée comme une petite économie mature ouverte (PEMO).A travers cette recherche, on s'attachera à appliquer et à adapter un modèle d'analyse des fondements de l'attractivité, puis un modèle de détermination des orientations économiques et institutionnelles à privilégier.Cette recherche conduit à définir une démarche prospective structurée, appliquée à la PEMO considérée :- en partant de l'établissement d'une liste de déterminants de compétitivité et d'attractivité ayant potentiellement trait à une PEMO en général, validée ensuite pour le cas concret du Luxembourg par un panel de décideurs ;- en permettant l'établissement d'un diagnostic d'attractivité portant sur la situation actuelle de la PEMO considérée ;- pour déboucher sur la détermination d'activités prioritaires et de profilsd'investisseurs directs étrangers à privilégier, dans un " espace de référence " géo - sectoriel reconsidéré.Cette recherche devrait permettre d'identifier les secteurs d'investissement les plus attractifs pour les entreprises étrangères dans une PEMO comme le Luxembourg.

Within the educational psychology literature there is an abundance of research in the field of metacognition. The concentration of this research however has been in primary and secondary school contexts with little attention given to tertiary students' understanding or use of metacognition; there has been even less attention to whether age is a factor in tertiary students' perceptions of their metacognitive processes. The primary purpose of this study was to explore the perceptions of two distinct groups of first year university students, towards their understanding and usage of metacognitive processes and strategies. The two groups defined were traditional school leavers and mature age students. The findings from the exploration of these perceptions were compared to ascertain the similarities and differences in metacognitive processes between the two cohorts. The data collected for this study were obtained through a process of individual face-to-face in- depth interviews. The choice of this methodology was deliberate in order to gather rich data about the students' perceptions and experiences rather than attempt to measure their levels of metacognition against some predetermined standard. Data were collected and analyzed on the two constructs of metacognition which were identified in the literature search. These were metacognitive knowledge and metacognitive control. A range of affective variables such as self efficacy, motivation and expectancy of success, which impact on students' metacognitive abilities and processes, were also considered in the data collection and analysis. The findings indicated that age was a factor in determining some differences and similarities in students' perceptions of their own and others metacognitive processes. In certain cases the traditional school leavers' recency of experience with formal study was deemed an advantage; in others the life experience of the mature age students was perceived an advantage. In some instances the age of the student had no discernable impact on their understanding of, and ability to, utilize metacognitive strategies. These findings assist to broaden the understanding of student perceptions of metacognition in the tertiary context. The findings also make it imperative that tertiary institutions make fewer assumptions about the skills and abilities of their commencing students based on the criterion of age and offer more opportunities to assist students to understand the value of developing and improving their metacognitive processes.

Submitted by Mia Saetre Bernhardsen (21288@novasbe.pt) on 2016-11-30T12:04:23Z No. of bitstreams: 1 MPGI Thesis Mia Bernhardsen.pdf: 945739 bytes, checksum: 2dd70ca4ba46c57038cd5d7107f42d03 (MD5) / Approved for entry into archive by Josineide da Silva Santos Locatelli (josineide.locatelli@fgv.br) on 2016-11-30T13:53:06Z (GMT) No. of bitstreams: 1 MPGI Thesis Mia Bernhardsen.pdf: 945739 bytes, checksum: 2dd70ca4ba46c57038cd5d7107f42d03 (MD5) / Made available in DSpace on 2016-11-30T17:27:28Z (GMT). No. of bitstreams: 1 MPGI Thesis Mia Bernhardsen.pdf: 945739 bytes, checksum: 2dd70ca4ba46c57038cd5d7107f42d03 (MD5) Previous issue date: 2016-11-03 / Within the field of international business and entrepreneurship, the following project investigates an underexplored topic, namely the post- establishment performance of maturing Born Globals relative to younger Born Globals in Hispanic America. The scope is delimited to viewing performance as of sales growth in the manufacturing sector. A quantitative approach is applied, where firm- level secondary data from 14 Latin American countries is analyzed using multiple regression with interaction terms. The results illustrate that maturing Born Globals tend to have lower sales growth compared to younger Born Globals, while failing to detect that product innovation affect younger and maturing Born Globals differently. Access to finance as a moderator appear to be insignificant in the full sample, while the findings in the Peruvian context illustrate that the sales growth of maturing Peruvian Born Globals is more negatively affected by difficulties in obtaining finance relative to their younger counterparts. / No âmbito dos campos de conhecimento -negócios internacionais e empreendedorismo- o seguinte projeto visa investigar um tema pouco explorado: o desempenho pós-estabelecimento de Born Globals maduras em relação com o de empresas Born Globals jovens na América hispânica. O escopo é limitado ao crescimento de vendas na indústria manufatureira. Foi utilizada uma abordagem quantitativa com informacão de 14 países latino-americanos ao nivel secundário das empresas, a través de regressao multipla com interação de termos. Os resultados mostram que Born Globals em maturidade tendem a ter um crescimento de vendas menor em comparação com jovens born globals. No entanto, não foi detectado uma evolução diferente no que toca a inovação do produto entre as empresas anteriormente referidas. O acesso a financiamento como um moderador parecem ser insignificantes na amostra total, entretanto os resultados no contexto peruano ilustram que o crescimento das vendas dos Born Globals em maturidade é afetado de forma negativa por dificuldades na obtenção de financiamento em relação às contrapartes jovens.

Made available in DSpace on 2014-12-17T14:08:54Z (GMT). No. of bitstreams: 1 HumbertoSC_DISSERT.pdf: 7792135 bytes, checksum: 5204c60825f60e9f74c5f24e46e8aa4e (MD5) Previous issue date: 2013-07-29 / Nearly 3 x 1011 m3 of medium and light oils will remain in reservoirs worldwide after conventional recovery methods have been exhausted and much of this volume would be recovered by Enhanced Oil Recovery (EOR) methods. The in-situ combustion (ISC) is an EOR method in which an oxygen-containing gas is injected into a reservoir where it reacts with the crude oil to create a high-temperature combustion front that is propagated through the reservoir. The High Pressure Air Injection (HPAI) method is a particular denomination of the air injection process applied in light oil reservoirs, for which the combustion reactions are dominant between 150 and 300?C and the generation of flue gas is the main factor to the oil displacement. A simulation model of a homogeneous reservoir was built to study, which was initially undergone to primary production, for 3 years, next by a waterflooding process for 21 more years. At this point, with the mature condition established into the reservoir, three variations of this model were selected, according to the recovery factors (RF) reached, for study the in-situ combustion (HPAI) technique. Next to this, a sensitivity analysis on the RF of characteristic operational parameters of the method was carried out: air injection rate per well, oxygen concentration into the injected gas, patterns of air injection and wells perforations configuration. This analysis, for 10 more years of production time, was performed with assistance of the central composite design. The reservoir behavior and the impacts of chemical reactions parameters and of reservoir particularities on the RF were also evaluated. An economic analysis and a study to maximize the RF of the process were also carried out. The simulation runs were performed in the simulator of thermal processes in reservoirs STARS (Steam, Thermal, and Advanced Processes Reservoir Simulator) from CMG (Computer Modelling Group). The results showed the incremental RF were small and the net present value (NPV) is affected by high initial investments to compress the air. It was noticed that the adoption of high oxygen concentration into the injected gas and of the five spot pattern tends to improve the RF, and the wells perforations configuration has more influence with the increase of the oil thickness. Simulated cases relating to the reservoir particularities showed that smaller residual oil saturations to gas lead to greater RF and the presence of heterogeneities results in important variations on the RF and on the production curves / Aproximadamente 3 x 1011 m3 de ?leos m?dios e leves restar?o nos reservat?rios ao redor do mundo ap?s a aplica??o dos m?todos convencionais de recupera??o e grande parte desse volume seria recuper?vel com o uso de m?todos especiais. A combust?o in-situ (CIS) ? um m?todo de recupera??o avan?ada de petr?leo no qual um g?s que cont?m oxig?nio ? injetado no reservat?rio onde reage com o ?leo cru para criar uma frente de combust?o de alta temperatura que se propaga pelo reservat?rio. O m?todo HPAI (High Pressure Air Injection) ? uma denomina??o particular do processo de inje??o de ar aplicado em reservat?rios de ?leos leves, onde as rea??es de combust?o s?o dominantes entre 150 e 300?C e a gera??o de flue gas ? o principal fator de deslocamento do ?leo. Um modelo de simula??o de fluxo de um reservat?rio homog?neo foi constru?do para o estudo, o qual foi inicialmente submetido ? produ??o prim?ria, por 3 anos, e em seguida, ao processo de inje??o de ?gua por mais 21 anos. Nesse ponto, com a condi??o madura estabelecida no reservat?rio, foram selecionadas tr?s varia??es desse modelo, de acordo com o fator de recupera??o (FR) obtido, para o estudo da t?cnica de combust?o in-situ (HPAI). Em seguida realizou-se uma an?lise de sensibilidade sobre o FR de par?metros operacionais pr?prios do m?todo: vaz?o de inje??o de ar por po?o, concentra??o de oxig?nio no g?s injetado, esquema de inje??o de ar e configura??o dos canhoneados dos po?os. Essa an?lise, para um per?odo adicional de at? 10 anos produ??o, foi efetuada com o aux?lio da t?cnica de planejamento composto central. O comportamento do reservat?rio e os impactos de par?metros envolvendo as rea??es qu?micas e de particularidades de reservat?rio sobre o FR tamb?m foram avaliados. Adicionalmente foram elaborados uma an?lise econ?mica e um estudo de maximiza??o do FR do processo. As simula??es foram realizadas com o simulador de processos t?rmicos em reservat?rios STARS (Steam, Thermal and Advanced Process Reservoir Simulation) da CMG (Computer Modelling Group). Os resultados mostraram que os FR incrementais foram baixos e que o valor presente l?quido (VPL) ? impactado negativamente pelos elevados investimentos iniciais para compress?o do ar. Observou-se que a ado??o de maiores concentra??es de oxig?nio no g?s injetado e do esquema de inje??o de ar tipo five spot tende a favorecer o FR, e que a configura??o dos canhoneados dos po?os apresenta influ?ncia crescente com o aumento da espessura porosa com ?leo do reservat?rio. Casos simulados referentes ?s particularidades de reservat?rio indicaram que menores satura??es residuais de ?leo ao g?s levam a FR maiores e que a exist?ncia de heterogeneidades resulta em varia??es consider?veis nos FR e nas curvas de produ??o

T-cell receptor (TCR) polyclonal mature T cells are surprisingly resistant to oncogenic transformation after retroviral insertion of T-cell oncogenes. In a mouse model, it has been shown that mature T-cell lymphoma/leukemia (MTCLL) is not induced upon transplantation of mature, TCR polyclonal wild-type (WT) T cells, transduced with gammaretroviral vectors encoding potent T-cell oncogenes, into RAG1-deficient recipients. However, further studies demonstrated that quasi-monoclonal T cells treated with the same protocol readily induced MTCLL in the recipient mice. It has been hypothesized that in the TCR polyclonal situation, outgrowth of preleukemic cells and subsequent conversion to overt malignancy is suppressed through regulation of clonal abundances on a per-clone basis due to interactions between TCRs and self-peptide-MHC-complexes (spMHCs), while these mechanisms fail in the quasi-monoclonal situation. To quantitatively study this hypothesis, we applied a mathematical modeling approach. In particular, we developed a novel ordinary differential equation model of T-cell homeostasis, in which T-cell fate depends on spMHC-TCR-interaction-triggered stimulatory signals from antigen-presenting cells (APCs). Based on our mathematical modeling approach, we identified parameter configurations of our model, which consistently explain the observed phenomena. Our results suggest that the preleukemic cells are less competent than healthy competitor cells in acquiring survival stimuli from APCs, but that proliferation of these preleukemic cells is less dependent on survival stimuli from APCs. These predictions now call for experimental validation.

<p>Glavni cilj ove doktorske disertacije je određivanje hemijskog sastava, biolo&scaron;kih i funkcionalnih karakteristika novih proizvoda od zove. Dobijanje proizvoda na bazi zove zasniva se na primeni tradicionalnih i savremenih tehnolo&scaron;kih procesa proizvodnje. Iskori&scaron;ćenje prirodnog potencijala zove započeto je primenom tradicionalne i savremene (liofilizacija) tehnike su&scaron;enja. U cilju dobijanja visoko-vrednih ekstrakata ploda i cveta zove primenjene su tradicionalna (maceracija) i savremene (ultrazvučna i mikrotalasna) ekstrakcione tehnike sa dva ekstragensa (50% etanol i voda). Dobijanje matičnog soka od plodova zove podrazumevalo je primenu tradicionalnog načina ceđenja, dok je vino od plodova zove dobijeno po standardnom postupku proizvodnje vina. Vino je izloženo različitim temperaturnim tretmanima u različitom vremenskom periodu (60 &deg;C u toku 5 minuta, 60 &deg;C u toku 10 minuta, 70 &deg;C u toku 5 minuta i bez toplotnog tretmana) u cilju evaluacije biolo&scaron;ke aktivnosti dobijenog proizvoda. Etarsko ulje ploda i cveta zove je dobijeno hidrodestilacijom. Ispitivanje efikasnosti primenjenih tehnolo&scaron;kih postupaka su&scaron;enja i ekstrakcije je zasnovano na određivanju biolo&scaron;kih i funkcionalnih karakteristika dobijenih ekstrakata ploda i cveta zove. U ispitivanim ekstraktima ploda i cveta zove dominantne fenolne kiseline su hlorogenska i protokatehinska kiselina, a rutin i kvercetin-3-O-heksozid su dominantna flavonoidna jedinjenja. Biolo&scaron;ke i funkcionalne karakteristike su ispitane primenom različitih in vitro antioksidativnih, neuroprotektivnih, antitirozinaznih i antidijabetogenih testova. Primenom liofilizacije kao savremene tehnike su&scaron;enja i mikrotalasne ekstrakcije kao savremene ekstrakcione tehnike povećava se biopotencijal ispitivanih ekstrakata. Matični sok od plodova zove kao potencijalno novi funkcionalni proizvod je analiziran u cilju definisanja hemijskog, fitohemijskog i nutritivnog sastava, biolo&scaron;kog potencijala i senzorskih karakteristika. Ispitivanja dobijenog vina su bila usmerena na utvrđivanje optimalnih uslova za proizvodnju voćnog vina. Definisanjem hemijskog i fitohemijskog sastava i evaluacijom biopotencijala vina određen je optimalan temperaturni profil za dobijanje jednog od novih funkcionalnih proizvoda. Na osnovu utvrđenog hemijskog sastava etarsko ulje ploda i cveta zove se pokazalo kao potencijalno novi prirodni agens za održavanje svežine i produženja roka trajanja prehrambenih proizvoda. Zova je nesumnjivo samonikla biljna vrsta koja u budućnosti osnovano može biti polazna sirovina za kreiranje i dobijanje novih prehrmabenih proizvoda na domaćem i inostranom trži&scaron;tu.</p> / <p>The main goal of this doctoral dissertation is to determine the chemical composition, biological and functional characteristics of new elderberry products. Elderberry products were obtained via traditional and modern technological processes. The exploitation of the natural potential of the elderberry started with the application of traditional and modern (lyophilization) drying techniques. To obtain high-value extracts of fruits and flowers, traditional (maceration) and modern (ultrasonic and microwave) extraction techniques with two solvents (50% ethanol and water) were applied. Obtaining the juice from the elderberry fruits implied the application of the traditional cold pressing method, whereas wine from the elderberry fruits was obtained in accordance with the standard procedure of wine production. The wine was exposed to different temperature treatments in different periods (60&deg;C for 5 minutes, 60&deg;C for 10 minutes, 70&deg;C for 5 minutes and without heat treatment) to evaluate the biological activity of the product. The essential oil of the fruit and flower was obtained by hydrodistillation. The examination of the efficiency of the applied technological procedures of drying and extraction is based on observing the biological and functional characteristics of the obtained extracts of the said fruits and flowers. In the examined fruit and flower extracts, the dominant phenolic acids are chlorogenic and protocatechuic acid, while rutin and quercetin-3-O-hexoside are the dominant flavonoid compounds. Biological and functional characteristics were examined using various in vitro antioxidant, neuroprotective, antityrosinase, and antidiabetic tests. The application of lyophilization and microwave extraction (as modern drying and extraction techniques) increased the biopotential of the analyzed extracts. Elderberry juice, a potentially new functional product, was analyzed to define the chemical, phytochemical and nutritional composition, biological potential, and sensory characteristics. The wine was tested in order to determine the optimal conditions for the production of fruit wine. By defining the chemical and phytochemical composition and evaluating the biopotential of wine, the optimal temperature profile for obtaining one of the new functional products was determined. Based on the obtained chemical composition, it is determined that the essential oil of fruits and flowers is a potentially new natural agent for maintaining freshness and extending the shelf life of food products. Without a doubt, elderberry is a wild plant species that could be used in the future as the starting material for creating and obtaining new food products on the domestic and foreign markets.</p>

No description available.

L’attractivité des territoires vis-à-vis des investissements directs étrangers constitue, avec l’ouverture accrue des espaces économiques et politiques, un élément clé de l’intensification des flux d’échanges et d’investissements.Pour tous les pays et, plus particulièrement, pour ceux ne disposant pas d’un marché national important, l’établissement d’un diagnostic d’attractivité et la détermination d’axes prioritaires de développement constituent une démarche fondamentale applicable particulièrement à l’exemple du Luxembourg, une économie considérée comme une petite économie mature ouverte (PEMO).A travers cette recherche, on s’attachera à appliquer et à adapter un modèle d’analyse des fondements de l’attractivité, puis un modèle de détermination des orientations économiques et institutionnelles à privilégier.Cette recherche conduit à définir une démarche prospective structurée, appliquée à la PEMO considérée :- en partant de l’établissement d’une liste de déterminants de compétitivité et d’attractivité ayant potentiellement trait à une PEMO en général, validée ensuite pour le cas concret du Luxembourg par un panel de décideurs ;- en permettant l’établissement d’un diagnostic d’attractivité portant sur la situation actuelle de la PEMO considérée ;- pour déboucher sur la détermination d’activités prioritaires et de profilsd’investisseurs directs étrangers à privilégier, dans un « espace de référence » géo - sectoriel reconsidéré.Cette recherche devrait permettre d’identifier les secteurs d’investissement les plus attractifs pour les entreprises étrangères dans une PEMO comme le Luxembourg. / Together with increased economic and political openness, a location’s or territory’s attractiveness and competitiveness for foreign direct investment (FDI) are key elements for intensifying investment and trade flows.For countries, especially those without a national market of significant scale, establishing a way to identify and analyse priorities for economic development is fundamental.This research defines a general analytical framework applicable to the concepts of attractiveness and competitiveness, and, building on this framework, develops a specific model that could assist key institutions as to identify their preferred orientations in the specific context of an economy considered as a small open mature economy (SOME), in particular, Luxembourg.This research will lead to the definition of a prospective structured approach by:- providing a list of factors which potentially influence the competitiveness and attractiveness of SOMEs; this list having been validated with respect to Luxembourgby national decision makers;- establishing a method for analysing the current situation regarding attractiveness and competitiveness in Luxembourg; and- identifying priority sectors for FDI that could be targeted in a specific location/territory of reference such as Luxembourg.

Abstract Bringing new products faster to the market is increasingly critical. To reach this goal, companies have been improving their product development practices and processes. Rapid product development (RaDe) is a type of incremental product development model, in which new sales items are created by redesigning existing products quickly and inexpensively. This study examines the RaDe challenges and enablers, particularly the ones from the perspective of supply management (SM) and product portfolio management (PPM). The main objective of this study is to recognise and describe the significance of mature SM for RaDe, resulting in successful and efficient product ramp-ups and portfolio renewal. The present study follows a qualitative research approach, which consists of reviewing the literature and analysing the relevant practices and current process settings of several companies representing diverse business areas and industry types. The principal results of this study involve acknowledging and describing the role of mature SM and organised PPM for effective RaDe implementation and product portfolio renewal. The study examines the mature SM from the perspective of 1) the definition of the SM objectives; 2) the alignment of the list of recommended products, buy-items and suppliers; 3) the creation of the product design guidelines, targets and metrics from the SM perspective; and 4) the establishment of the supply capability creation process. The main implications of the present study highlight the importance of the SM maturity that can support managers in RaDe related planning and implementation activities. The originality of the study resides in the emphasis of the SM significance in terms of different aspects that are beneficial to RaDe implementation and product portfolio renewal. / Tiivistelmä Uusien tuotteiden tuominen markkinoille nopeasti on enenevissä määrin tärkeää yrityksille. Tämän saavuttamiseksi yritykset ovat pyrkineet parantamaan tuotekehitystoimintojaan ja -prosessejaan. Nopea tuotekehitys (RaDe) on malli inkrementaaliseen tuotekehitykseen, missä myyntinimikkeitä luodaan uudelleen suunnittelemalla jo olemassa olevia tuotteita nopeasti ja halvalla. Tämä tutkimus tarkastelee RaDe -haasteita ja mahdollistajia, erityisesti hankintatoimen johtamisen (SM) ja tuoteportfoliohallinnan (PPM) näkökulmasta. Tutkimuksen ensisijaisena tavoitteena on tunnistaa ja kuvata kypsän hankintatoimen johtamisen ja nopean tuotekehityksen merkittävyys niin onnistuneen kuin tehokkaan markkinoille tuonnin sekä tuoteportfolion uudistamisen mahdollistajana. Laadullinen tutkimus tarkastelee monipuolisia liiketoiminta-alueita ja teollisuusaloja, koostuen sekä kirjallisuuskatsauksesta että useiden eri yritysten niille relevanttien toimintojen ja prosessien analysoinnista. Keskeiset tutkimuksen tulokset osoittavat ja selittävät kypsän hankintatoimen johtamisen ja organisoidun tuoteportfoliohallinnan roolia nopean tuotekehityksen tehokkaassa toteutuksessa sekä tuoteportfolion uudistamisessa. Kypsää hankintatoimen johtamista tutkimus tarkastelee seuraavista perspektiiveistä: 1) hankintatoimen johtamisen tavoitteiden määritys, 2) suositeltujen tuote-, ostoartikkeli- ja toimittajalistojen linjaus, 3) tuotesuunnittelun ohjeistusten, tavoitteiden ja mittareiden luominen hankintatoimen johtamisen näkökulmasta, ja 4) hankintatoimen kyvykkyyden perustamisen luomisprosessi. Tutkimuksen merkittävimmät kontribuutiot organisaatioille korostavat sellaisen kypsän hankintatoimen johtamisen tärkeyttä, mikä tukee johtoa nopean tuotekehityksen suunnittelussa ja toteutuksessa. Uudenlaista näköalaa tutkimukseen tuottaa hankintatoimen johtamisen merkityksen tähdentyminen positioista, jotka ovat suotuisia nopean tuotekehityksen toteutukselle sekä tuoteportfolion uudistumiselle.