Orientadores: Cristina Laguna Benetti Pinto, Daniela Angerame Yela Gomes / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas / Made available in DSpace on 2018-08-21T21:47:45Z (GMT). No. of bitstreams: 1 Ferreira_SilviaRegina_M.pdf: 4150718 bytes, checksum: cd59beb6b418efdb06f6bbe2ca08f78f (MD5) Previous issue date: 2013 / Resumo: Introdução: A síndrome dos ovários policísticos (SOP) é uma desordem endócrina com alta prevalência que se caracteriza por oligomenorreia ou amenorréia, sinais clínicos e/ou bioquímicos de hiperandrogenismo, ovários policísticos. Tem como principais manifestações a irregularidade menstrual, hirsutismo e infertilidade, além de relacionar-se à obesidade, síndrome metabólica, hipertensão e diabetes mellitus. Estes sintomas e repercussões em longo prazo podem impactar negativamente a qualidade de vida e sexualidade das mulheres. Objetivo: Avaliar a qualidade de vida e a sexualidade em mulheres com SOP, a influência da obesidade nestes aspectos. Desenho do Estudo: Estudo de coorte transversal. Material e Métodos: Foram avaliadas 150 mulheres com 18 a 40 anos, com diagnóstico de SOP, atendidas no período de janeiro a novembro de 2011 no Ambulatório de Ginecologia Endócrina do Departamento de Ginecologia e Obstetrícia da Faculdade de Ciências Médicas da Universidade Estadual de Campinas (UNICAMP), sendo que 56 preencheram os critérios de inclusão. O grupo de controle foi composto por 102 mulheres com ciclos menstruais regulares, sem sinais de hiperandrogenismo clínico. Todas responderam a questionários para avaliação da função sexual (Índice de Função Sexual Feminina- IFSF) e da qualidade de vida (WHOQOL- bref). Análise Estatística: Utilizou-se o teste de Kolmogorov-Smirnov para avaliar a distribuição normal. Como os dados não apresentassem distribuição normal foi utilizado o teste de Mann-Whitney para a comparação entre os grupos. Foi adotado o nível de significância de 5% e o software utilizado para análise o SAS versão 9.2. Resultados: As mulheres com SOP e controles tinham média de idade de 26,98±4,9 e 35,6±7,3 anos, respectivamente (p<0,0001). O IMC médio era de 31,9±8,5 e 28,5±5,4 kg/m2 respectivamente (p<0,02). Na avaliação de qualidade de vida, verificou-se que as mulheres com SOP apresentaram pior escore no domínio em que avaliavam sua condição de saúde (p=0,01) e no escore total do WHOQOL-bref (p=0,02) do que as mulheres do grupo de controle. Com relação à função sexual, os grupos não diferiram para desejo sexual e orgasmo, porém excitação (p=0,03), lubrificação (p=0,04), satisfação (p<0,001), dor (p=0,01) e o escore total do IFSF (p=0,005) foram piores na presença de SOP do que nas mulheres do grupo de controle. No grupo com SOP, a presença de obesidade piora significativamente os domínios físico, psicológico, meio ambiente, saúde e o escore total de qualidade de vida, assim como reduz os domínios orgasmo e o índice de função sexual feminina. Conclusões: Mulheres com SOP apresentaram piora na qualidade de vida e na função sexual em relação a mulheres com função gonadal normal. O peso acima do normal é um fator de piora destes aspectos / Abstract: Introduction: Polycystic ovary syndrome (POS) is an endocrine disorder with a high prevalence rate, characterized by oligomenorrhea or amenorrhea, clinical and/or biochemical signs of hyperandrogenism and polycystic ovaries. The main manifestations of the disorder are irregular menses, signs of hirsutism and infertility, in addition to its relationship with obesity, metabolic syndrome, hypertension and diabetes mellitus. Over the long term, these symptoms and repercussions may negatively impact quality of life and sexuality in affected women. Objective: To assess quality of life and sexuality in women with POS, as well as the influence of obesity on these aspects. Study Design: A cross-sectional design was conducted. Material and Methods: One hundred and fifty women aged 18 to 40 years, diagnosed with POS were assessed. These women had been seen from January to November 2011 in the Gynecological Endocrinology Outpatient Facility at the Department of Obstetrics and Gynecology in the Universidade Estadual de Campinas (UNICAMP) School of Medicine. Of the total number of women, fifty-six patients fulfilled the inclusion criteria. The control group was composed of 102 women with regular menstrual cycles, with no signs of clinical hyperandrogenism. All responded to questionnaires evaluating sexual function (Female Sexual Function Index-FSFI) and quality of life (WHOQOL- bref). Statistical analysis: The Kolmogorov-Smirnov test was used to assess normal distribution. Since data did not show a normal distribution, the Mann-Whitney test was used to compare the scores between both groups. A significance level of 5% was adopted and the software used for analysis was SAS version 9.2. Results: The mean age of patients with POS was 26.98±4.9 and 35.6±7.3 years, respectively (p<0.0001). The mean BMI was 31.9±8.5 and 28.5±5.4 kg/m,2 respectively (p<0.02).In the quality of life assessment, it was observed that women with POS had worse scores in the domain evaluating their health status(p=0.01) and total WHOQOL-brefs core (p=0.02) than women in the control group. Regarding sexual function, the groups did not differ in terms of sexual desire and orgasm, although arousal (p=0.03), lubrication (p=0.04), satisfaction (p<0.001), pain (p=0.01) and total FSFI score (p=0.005) were worse in the POS group, when compared to women from the control group. In the POS group, the presence of obesity significantly worsened the domains of physical health, psychological, environment, health status and total quality of life scores, as well as lowered the domain scores of orgasm and female sexual function index. A comparison between both groups of women with BMI indicating overweight or obesity, showed no difference in quality of life or sexual function. Conclusions: Women with POS had a worse quality of life and sexual functioning, in comparison to women with normal gonadal function. Weight above normal is a factor that worsens these aspects / Mestrado / Fisiopatologia Ginecológica / Mestra em Ciências da Saúde

A síndrome dos ovários policísticos (SOP) é o distúrbio endócrino-metabólico mais frequente na menacme, com prevalência de 7 a 10 %, contribuindo com o aumento do risco cardiovascular e/ou diabetes mellitus tipo II nessas mulheres. OBJETIVOS: Identificar as características epidemiológicas e os diferentes fenótipos da SOP, a prevalência da síndrome metabólica encontrada em cada fenótipo e os fatores associados ao risco metabólico dessas pacientes. CASUÍSTICA E MÉTODO: Estudo observacional com 566 mulheres entre 14 e 39 anos portadoras de SOP, segundo o consenso de Rotterdam. O risco metabólico foi avaliado pela análise descritiva com intervalo de confiança de 95%. As variáveis quantitativas foram testadas pelo método de Shapiro-Wilk e teste não paramétrico de Mann-Whitney. Para a análise multivariada usou-se a razão de prevalências entre as diversas variáveis independentes e o desfecho risco metabólico. Identificamos os fatores associados ao risco metabólico empregando a regressão de Cox com variância robusta. RESULTADOS: Das 566 pacientes, 27,9% tinham entre 20 e 24 anos; 84,5% eram afrodescendentes; 90,6% apresentavam irregularidade menstrual; 91,8% hirsutismo; 77,7% ovários aumentados e/ou policísticos; 15,7% com pelo menos um filho; IMC elevado em 66,5%; CA superior a 88 em 51%; pressão arterial sistólica e diastólica elevadas em 38,9% e 20% das pacientes respectivamente; 7,7% intolerância a carboidratos, 40,8% de HDL-colesterol reduzido, 8,8% de triglicerídeos elevados. Encontramos risco metabólico em 21%, com predomínio dos fenótipos E (28,4%), B (25%) e A (22%). Antecedentes familiares de diabete, hipertensão arterial, câncer ginecológico e câncer não ginecológico não contribuíram, com significância estatística, para o aumento de eventos metabólicos. O acréscimo de um ano na idade elevou o risco em 5%. A cada subida de uma unidade no IMC foram adicionados 8%. A presença de hirsutismo triplicou o risco. Pacientes com pelo menos um filho apresentaram duas vezes mais síndrome metabólica do que as sem filhos. CONCLUSÕES: Foi observada maior frequência de síndrome metabólica entre os fenótipos que apresentam em comum oligoanovulação e hirsutismo (E, B e A). Em pacientes com SOP a idade, a paridade, a presença de hirsutismo e obesidade foram os fatores independentemente relacionados ao aumento do risco metabólico / Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder that is more frequent in premenopausal, affecting 7 to 10% of women, contributing to the increase of cardiovascular and/or type II diabetes mellitus risk. OBJECTIVES: To identify the epidemiological characteristics and different phenotypes of PCOS, the prevalence of metabolic syndrome found in each phenotype and metabolic risk factors associated with these patients. PATIENTS AND METHODS: Observational study of 566 women between 14 and 39 years with PCOS according to the Rotterdam criteria. The metabolic risk was assessed by descriptive analysis with a confidence interval of 95%. Quantitative variables were tested by using Shapiro-Wilk method and nonparametric Mann-Whitney test. For the multivariate analysis the prevalence ratio between several independent variables and the outcome metabolic risk were used. Factors associated with the metabolic risk were identified by using Cox regression with a robust variance. RESULTS: Of 566 patients, 27.9% were between 20 and 24 years, 84.5% were of African descents; 90.6% had oligoanovulation; 91.8% hirsutism; 77.7% enlarged ovaries and/or polycystic, 15.7% with at least one child in high BMI 66.5%, CA 88 exceeding 51%; systolic and diastolic blood pressure elevated by 38.9% and 20% of patients, respectively, 7.7% carbohydrate intolerance, 40.8% HDL-cholesterol changed, 8.8% triglyceride levels. Metabolic risk found in 21%, with a predominance of E phenotypes (28.4%), B (25%) and A (22.1%). Family history of diabetes, hypertension, gynecological cancer and gynecological cancer does not contribute with statistical significance for increased metabolic events. The one-year increase in age raised the risk by 5%. Every increase of one unit in BMI 8% were added. Presence of hirsutism tripled the risk. Patients with at least one child were twice as metabolic syndrome than those without children. CONCLUSIONS: A higher frequency of metabolic syndrome phenotypes that have in common oligoanovulation and hirsutism (E, B and A) were observed. Independently associated factors with the metabolic risk in PCOS patients were age, parity, hirsutism and obesity

The purpose of this study was to investigate the relative contributions of previously identified Polycystic ovary syndrome (PCOS) manifestations (infertility, hirsutism, obesity, menstrual problems) to multiple psychological symptoms. Participants were 126 female endocrinology patient volunteers diagnosed with PCOS who completed a cross-sectional study of PCOS manifestations and psychological symptoms. Participants had significantly elevated scores on nine subscales of psychological symptoms. Menstrual problems were significantly associated with all symptom subscales as well as the global indicator, while hirsutism and obesity were significantly related to five or more subscales. After controlling for demographic factors, menstrual problems were the strongest predictor of psychological symptoms. Findings suggest features of excess body hair, obesity, and menstrual abnormalities carry unique risks for adverse psychologic symptoms, but menstrual problems may be the most salient of these features and deserve particular attention as a marker for psychological risk among women with PCOS.

Bakgrund: Polycystiskt ovariesyndrom (PCOS) är en endokrin sjukdom som drabbar kvinnor i fertil ålder. PCOS har en mängd symtom som påverkar patientens mående genom förändrat utseende och infertilitet. Trots detta framgår det att förhållningssättet gentemot patientgruppen är komplex.  Syfte: Syftet med studien var att beskriva kvinnors upplevelse av att leva med polycystiskt ovariesyndrom. Metod: En kvalitativ litteraturstudie som inkluderar nio originalartiklar. Data analyserades med kvalitativ innehållsanalys med stöd från Graneheim och Lundman. Resultat: Tre kategorier med åtta subkategorier presenteras. De tre kategorierna är kvinnans kontakt med sjukvården, kvinnans upplevda självbild samt sjukdomens roll i samlivet. Resultatet indikerar att gemensamt för kvinnorna är en känsla av frustration och sorg kring symtomen övervikt, ansiktsbehåring och infertilitet. Slutsats: Det är av vikt med fortsatt forskning för att kunna implementera tydligare riktlinjer kring handhavandet av patientgruppen och tillika mer djupgående omvårdnadsåtgärder redan innan diagnostisering, för minskat lidande. / Background: Polycystic ovary syndrome (PCOS) is an endocrine disease that affects fertile women. PCOS has a variety of symptoms that affects the patient's mood through altered appearance and infertility. Despite this, it appears that the approach to the patientgroup is complex. Aim: The aim of this study was to describe women’s experience of living with polycystic ovary syndrome. Method: A qualitative literature review that includes nine original articles. Data were analyzed by a qualitative content analysis with support in Graneheim and Lundman. Results: Three categories with eight subcategories are presented. The three categories are the woman’s contact with healthcare, the woman’s perceived self-image and the role of the disease in cohabitation. The results indicate that common to the women is a feeling of frustration and sadness around the symptoms of obesity, facial hair and infertility. Conclusions: Continued research is important to be able to implement clearer guidelines for the management of the patient group and more in-depth nursing measures already within diagnosis, for reduced suffering.

Bakgrund: Polycystiskt ovarialsyndrom (PCOS) orsakas av obalans i kvinnans könshormoner och leder till bildning av cystor i äggstockarna. Syndromet rubbar kroppens hormonella och metabola funktioner vilket kan leda till övervikt och en negativ inverkan på kvinnans hälsa och livskvalitet. Vid PCOS rekommenderas livsstilsförändringar som första behandlingsalternativ i syfte att förbättra hälsan kortsiktigt och långsiktigt. Syfte: Syftet var att beskriva kvinnors upplevelser av livsstilsförändringar vid PCOS ur ett omvårdnadsperspektiv. Metod: En allmän litteraturstudie med induktiv ansats som baserades på strukturerade artikelsökningar. Elva artiklar med innehåll som svarade mot syftet bearbetades i en innehållsanalys. Resultat: Analysen resulterade i två huvudkategorier där den ena benämndes som Betydelsen av information om livsstilsförändringar och den andra som Värdet av att bemöta kvinnors omvårdnadsbehov. Kvinnor beskrev vårdpersonalens brist på kunskap om livsstilsförändringar som behandling vid PCOS. Vårdens bristande kunskap ledde till att de fick otillräcklig information och omvårdnad. De efterfrågade en omvårdnad som såg till alla deras behov. Konklusion: Berörda kvinnor skulle gynnas av att hälso- och sjukvårdspersonal får utbildning generellt om PCOS samt specifikt hur livsstilsförändringar kan förbättra symtombild och förhindra utveckling av följdsjukdomar. / Background: Polycystic ovary syndrome (PCOS) is caused by imbalance in the female sex hormones, resulting in cystic ovaries. It also effects the hormonal and metabolic functions, which can lead to obesity and a negative impact on the overall health and quality of life. Lifestyle changes is the first-line treatment to improve women’s health both short and long term. Aim: To describe women’s experiences of lifestyle changes in PCOS, from a caring perspective. Method: A general literature study with an inductive approach was conducted. Eleven articles responded to the aim of the study and were analyzed through content analysis. Result: Based on the analysis the result was divided into two main categories; The importance of information on lifestyle changes and The value of meeting women’s nursing care needs. Women described the caregivers lack of knowledge regarding lifestyle change as treatment in PCOS. Women experienced that the caregivers lack of knowledge resulted in them receiving insufficient or missing information. Therefore, women emphasized the necessity of a nursing care that covered all their needs. Conclusion: Affected women would benefit from health care professionals receiving education on PCOS and specifically how lifestyle changes can improve the symptom picture and prevent the development of sequelae.

Objective: Polycystic ovary syndrome (PCOS) is a multidimensional endocrine disorder and the leading female infertility. PCOS is characterized as a clustering of clinical concerns, which include hyperandrogenism, obesity, and menstrual abnormalities/infertility. These characteristics were examined with regard to their impact on women's psychosocial concerns and health related quality of life. Design: Cross-sectional, correlational Setting: Private endocrinology practice in the rural Southeastern U.S. Participants: The study sample consisted of 126 women with PCOS. Methods: Convenience sampling yielded 126 subjects who met the diagnosis for PCOS, underwent laboratory testing and physical assessment, completed psychological and quality of life survey instruments and were included in data analysis. Results: Results of multiple regression analyses, controlling for demographic covariates, were completed on markers of hyperandrogenism, obesity and current fertility intent. Findings revealed hirsutism was significantly related to increased symptoms of anxiety and somatization and decreased quality of life among women with PCOS, while elevated androgen levels were significantly related to decreased quality of life. Current fertility intent significantly impacted symptoms related to interpersonal sensitivity, anxiety, psychoticism, and the global symptom severity index. Specifically, women not currently trying to conceive had higher levels of these psychological symptom outcomes. Conclusion/Implications for nursing practice: Women with PCOS are at elevated risk for psychological distress, and psychological symptoms appear to increase with increasing severity of PCOS symptoms. Women not currently trying to conceive appear to be at higher risk for psychological distress and lower quality of life.

Objective: Polycystic ovary syndrome (PCOS) is a multidimensional endocrine disorder and the leading female infertility. PCOS is characterized as a clustering of clinical concerns, which include hyperandrogenism, obesity, and menstrual abnormalities/infertility. These characteristics were examined with regard to their impact on women's psychosocial concerns and health related quality of life. Design: Cross-sectional, correlational Setting: Private endocrinology practice in the rural Southeastern U.S. Participants: The study sample consisted of 126 women with PCOS. Methods: Convenience sampling yielded 126 subjects who met the diagnosis for PCOS, underwent laboratory testing and physical assessment, completed psychological and quality of life survey instruments and were included in data analysis. Results: Results of multiple regression analyses, controlling for demographic covariates, were completed on markers of hyperandrogenism, obesity and current fertility intent. Findings revealed hirsutism was significantly related to increased symptoms of anxiety and somatization and decreased quality of life among women with PCOS, while elevated androgen levels were significantly related to decreased quality of life. Current fertility intent significantly impacted symptoms related to interpersonal sensitivity, anxiety, psychoticism, and the global symptom severity index. Specifically, women not currently trying to conceive had higher levels of these psychological symptom outcomes. Conclusion/Implications for nursing practice: Women with PCOS are at elevated risk for psychological distress, and psychological symptoms appear to increase with increasing severity of PCOS symptoms. Women not currently trying to conceive appear to be at higher risk for psychological distress and lower quality of life.

Objective: Polycystic ovary syndrome (PCOS) is a multidimensional endocrine disorder characterized by at least two of the following three features: hyperandrogenism, ovulatory dysfunction and/or polycystic ovaries. Prevalence is estimated at 5-10 % of women of reproductive age worldwide and may impact between five and ten million women in the U.S. alone. Rather than a distinct disease entity, PCOS is characterized as a clustering of clinical concerns which include hyperandrogenism, obesity, and menstrual abnormalities/infertility. Our intent was to examine how these three PCOS characteristics impact psychological symptoms (e.g., depression, anxiety, interpersonal sensitivity) and PCOS health related quality of life concerns (weight, hair, infertility, menstrual, emotions). Design: Cross-sectional, correlational Setting: Women were recruited from private endocrinology practices in the rural Southeastern U.S. Patients/Participants: The study sample consisted of 126 women with PCOS. Half of these women were currently attempting to conceive in addition to being treated for their PCOS. The average woman in the study was 30 years of age (M=30.3, range=18-48), White (98 %) and married (79%). On average, participants weighed over 200 pounds (M=213.6 lbs, 116-361 lbs). Methods: During the seven-month enrollment period, women diagnosed with PCOS were invited to participate. Convenience sampling yielded 126 subjects who met the diagnosis for PCOS, underwent laboratory testing and physical assessment, completed psychological and quality of life survey instruments and were included in data analysis. Results: Results of multiple regression analyses, controlling for demographic covariates, were completed on markers of hyperandrogenism, obesity and current fertility intent. Findings revealed hirsutism was significantly related to increased symptoms of anxiety and somatization and decreased quality of life among women with PCOS, while elevated androgen levels were significantly related to decreased quality of life. Insulin level predicted increased levels of symptoms related to somatization, psychoticism, and a global symptom severity index. Current fertility intent significantly impacted symptoms related to interpersonal sensitivity, anxiety, psychoticism, and the global symptom severity index. Specifically, women not currently trying to have a baby had higher levels of these psychological symptom outcomes. Conclusion/Implications for nursing practice: Women with PCOS are at elevated risk for psychological distress, and psychological symptoms appear to increase with increasing severity of PCOS symptoms. Women not currently trying to conceive appear to be at higher risk for psychological distress and lower quality of life. Future attention might focus on screening and possible referring to mental health services for women not trying or no longer trying to conceive.

Background: Polycystic ovary syndrome (PCOS) affects 5–20% of women of reproductive age worldwide and is associated with disorders of glucose metabolism. Hormone and metabolic signaling may be influenced by phytoestrogens, such as isoflavones. Their endocrine effects may modify symptom penetrance in PCOS. Equol is one of the most active isoflavone metabolites, produced by intestinal bacteria, and acts as a selective estrogen receptor modulator. Method: In this interventional study of clinical and biochemical characterization, urine isoflavone levels were measured in PCOS and control women before and three days after a defined isoflavone intervention via soy milk. In this interventional study, bacterial equol production was evaluated using the log(equol: daidzein ratio) and microbiome, metabolic, and predicted metagenome analyses were performed. Results: After isoflavone intervention, predicted stool metagenomic pathways, microbial alpha diversity, and glucose homeostasis in PCOS improved resembling the profile of the control group at baseline. In the whole cohort, larger equol production was associated with lower androgen as well as fertility markers. Conclusion: The dynamics in our metabolic, microbiome, and predicted metagenomic profiles underline the importance of external phytohormones on PCOS characteristics and a potential therapeutic approach or prebiotic in the future.

No description available.