Made available in DSpace on 2016-07-18T17:53:14Z (GMT). No. of bitstreams: 1 Cristina Cecilia.pdf: 245966 bytes, checksum: 7e28e7fd7df013e4d0bfb113581dba6e (MD5) Previous issue date: 2014-12-05 / This study evaluated the effect of supplementation with a combination of probiotic microorganisms, added to a mineral mixture in different doses/day, in the production of serum antibodies against the rabies virus in primo vaccinated cattle. Forty-two male Nelore cattle, divided into three groups (n = 14): control group (CG) received 70 grams of mineral mixture/animal/day; probiotic groups 4 grams (G4P) and 8 grams (G8P) received 70 grams of mineral mixture/animal/day with 4 and 8 grams of added probiotics respectively. The individual anti-rabies antibody titers were determined using the technique of seroneutralization in cells based on the Rapid Fluorescent Focus Inhibition Test (RFFIT). The results obtained were compared using the unpaired t test with a 5% significance level. There were statistical differences in the mean serum concentrations between the CG, G4P and G8P groups, 30 and 60 days after the primo vaccination and after 60 days only the G8P group demonstrated minimum protective antibody titers in 100% of the animals. There is evidence of beneficial effects attributed to the association between probiotic microorganisms and the anti-rabies humoral immune response; in addition, an increase in the dose incorporated into the mineral mixture maintains high levels of serum antibodies in primo vaccinated cattle. / Esse estudo avaliou o efeito da suplementação de uma associação de microrganismos probióticos, adicionados à mistura mineral em diferentes doses/dia, na produção de anticorpos séricos contra o vírus rábico em bovinos primovacinados. Quarenta e dois bovinos Nelore machos, divididos em três grupos (n=14): grupo controle (GC) recebeu 70 gramas de mistura mineral/animal/dia; grupos probióticos 4 gramas (G4P) e 8 gramas (G8P) receberam 70 gramas de mistura mineral/animal/dia adicionados respectivamente de 4 e 8 gramas de probióticos. Os títulos individuais de anticorpos antirrábicos foram determinados por meio da técnica de soroneutralização em células baseado no Rapid Fluorescent Focus Inhibition Test (RFFIT). Os resultados obtidos foram comparados pelo teste t não pareado, com 5% de nível de significância. Houve diferenças estatísticas significativas entre as médias de concentrações séricas entre os grupos GC e os G4P e G8P, após 30 e 60 dias da primovacinação e após 60 dias somente o G8P manteve 100% dos animais com títulos de anticorpos protetores mínimos. Existem evidências para se atribuir efeito benéfico à associação de microrganismos probióticos na resposta imune humoral antirrábica e ao aumento da sua dose incorporada na mistura mineral e sobre a manutenção de elevados níveis de concentração sérica de anticorpos nos bovinos primovacinados.

East Tennessee State University recently adopted Alma & Primo and was suprised by the lack of an A-Z database discovery module. Frustrated by having to maintain electronic resources separately on our library website and in Alma, we embarked on a goal to eliminate redundancy and use Alma/Primo exclusively. This presentation will cover our entire workflow in both Alma & Primo and the issues we encountered along the way. I'll first go over our process in Alma including MARC record creation, electronic collection setup, and the top level collection module. Next, I'll cover our workflow in Primo including normalization rules, scoping, PNX display, facets, and code table changes. The last section will cover the Primo X-Services API and how it was developed into an A-Z Database list.

Transhumanism is a philosophy and a contemporary movement dedicated to improving the human condition in various ways. This thesis explores how the transhumanist movement contributes to the contemporary conceptualization or reconceptualization of the human body and the human condition. Furthermore, this thesis discusses three transhumanist key concepts, namely Mind Uploading, Cryonics, and the Primo Posthuman, and how these ideas might affect the research participants’ understanding and enactment of the human body and the human condition. By relying on ethnographic methods, including semi-structured interviews and participant observations from a 12-week fieldwork in Arizona, the ethnographic material is then discussed with the use of Annemarie Mol’s body multiple theory. In addition to this, the material is also analyzed with literature discussing the three main themes of this thesis, namely the re-conceptualization of the body, the mind, and body dualism, and the redefinition of death and the dying body. The ethnographic material and the accounts made from the research participants illustrate that the body is enacted and understood as insufficient and fragile, cartesian, a current vehicle readable and quantifiable through numbers and graphs, and a body whose mind can be uploaded into a computational substrate by the transhumanist community. It also describes how the body can be enacted as alive, an anatomical object, and a body with agency and personhood. Furthermore, the thesis concludes that the transhumanist movement contributes to the contemporary conceptualization and reconceptualization of the human body and the human condition by enacting multiple bodies as well as discussing and imagining new possible human conditions and human bodies. Lastly, this thesis does not only address important anthropological questions regarding ontology and the enactment of the human body. It also discusses relevant questions about humans and technology, as well as questions regarding death and imagination.

Esta tesis doctoral se propone establecer un estudio de conjunto sobre los cambios y permanencias que se producen en la provincia de Alicante durante la dictadura de Primo de Rivera. En este sentido, la tesis se estructura en seis capítulos que siguen una secuenciación temática y cronológica. El primer título de la tesis aborda el marco historiográfico de la Dictadura, prestando especial atención a la evolución conceptual e interpretativa que ha conocido el estudio del régimen primorriverista. El segundo apartado se reserva al análisis de las causas conducentes al pronunciamiento militar. En él se abordan las condiciones previas al pronunciamiento militar desde una doble perspectiva: Una nacional, donde se describe el funcionamiento del sistema de Restauración y los elementos que determinaron su crisis. Y otra regional, que explica los antecedentes al golpe de Estado desde una óptica provincial, repasando los particularismos económicos, demográficos, políticos y sociales de la Alicante previa a la Dictadura. El tercer capítulo estudia el desarrollo del pronunciamiento militar y sus inmediatas repercusiones en Alicante. Mediante una contextualización comparada abordamos la connivencia de la oficialidad alicantina con la sublevación y las reacciones de los diversos grupos sociales al golpe de Estado. El segundo apartado de este capítulo analiza los fundamentos del ideario regeneracionista del Dictador y explica que parte del respaldo social que recibió inicialmente se debió a la estrategia de incorporar ese argumentario al mensaje oficial. El cuarto capítulo comprende todo el periodo de la Dictadura, pero profundiza concretamente en dos aspectos temáticos: El primero, en el periodo de fiscalización inicial, que afecta a la fase de desmantelamiento de las estructuras político-administrativas del régimen canovista (octubre de 1923-abril de 1924). En estos subapartados se estudia la repercusión de la política anticaciquil y fiscalizadora en las comarcas alicantinas: las medidas de moralización de las costumbres, la destitución de los antiguos representantes públicos, la auditoria de las administraciones, la censura de la opinión pública y la represión político-sindical. El segundo aspecto compete al estudio del Gobierno Civil de Alicante. Dado que la gestión política durante la Dictadura estuvo fuertemente centralizada y militarizada, en esta sección se analizan los órganos de la autoridad central del Estado en la provincia de Alicante. Se describe la concentración de funciones en los gobernadores cívico-militares, su papel como interlocutores del Dictador y se hace un repaso a su perfil ideológico y profesional. A continuación, se detalla el cometido de una institución original de la Dictadura, la Junta Ciudadana de Autoridades. En cuanto a los delegados gubernativos, una autoridad militarizada y creada ex novo, examinamos su evolución para averiguar por qué se convirtieron en una institución tan cuestionada. El capítulo quinto se refiere a la administración local y provincial. Este título es esencial para entender cómo funciona el poder local durante la dictadura primorriverista. En sus diversos apartados se estudia la renovación política y administrativa que se produce en estas instituciones, el personal que las compone, la repercusión que tuvo en el funcionamiento de estos organismos la aprobación del Estatuto Municipal y Provincial y, en su última sección, la política económica, fiscal y presupuestaría que aplican. El capítulo final se ocupa de dos de las organizaciones más genuinas de la Dictadura: el Somatén y la Unión Patriótica. La primera se concibió como una milicia cívica garante del orden público y la paz burguesa, y el segundo como un partido gubernamental encargado de crear una base social de apoyo al régimen y de preparar a los hombres destinados a ocupar los cargos públicos de la Dictadura.

Le microbiote intestinal comprend l’ensemble des micro-organismes présents dans le tractus digestif. Cette flore et sa variabilité est unique et spécifique à chaque individu. L’équilibre microbien, état critique pour la santé, se développe progressivement à partir de la naissance. En complément de la fonction connue du microbiote dans la digestion, son rôle est maintenant avéré comme central dans le métabolisme humain. Dans cet écosystème complexe dans lequel cohabitent et interagissent 10¹³ bactéries, les Bacteroides, genre majoritaire au sein du microbiote, prennent en charge les fibres non digestibles de l’alimentation. Ces bactéries, anaérobies à Gram négatif, sont particulièrement bien adaptées à l’environnement intestinal tout particulièrement dans le domaine de la prise en charge des polysaccharides complexes et celui de la résistance à l’oxygène. Etonnamment, bien que l’hème soit un métabolite requis pour la croissance des Bacteroides, ces bactéries sont incapables de le synthétiser. L’hème, constitué d’un atome de fer fixé sur une porphyrie, est un cofacteur impliqué dans de nombreuses réactions enzymatiques essentielles au métabolisme central. Sa réactivité biochimique le rend responsable d’une induction de phénomènes inflammatoire de l’intestin. Nous avons étudié les interactions entre la bactérie Bacteroides thetaiotaomicron et l’hème environnemental. Nous avons d’abord développé un test permettant la détection de quantités d’hème de l’ordre du nanogramme dans des milieux complexes tels que le contenu intestinal. Nous avons ensuite montré que la bactérie commensale E. coli n’est pas la principale source d’hème lors de la colonisation du tractus digestif par Bacteroides dans un modèle de souris axénique et que l’hôte rempli ce rôle. Nous avons mis en place un système permettant de moduler la quantité d’hème présente dans le tractus digestif en piégeant la molécule sur l’hémophore HasA de Serratia marcescens. Nous avons confirmé que le système HasA était actif in vitro. Les résultats préliminaires montrent que d’une part il réduit la quantité d’hème intestinal disponible et d’autre part cela entraine un retard lors de la colonisation du tractus digestif par Bacteroides. Ce travail fournit des outils permettant de mieux comprendre les facteurs influant sur l’implantation des Bacteroides et souligne l’importance de l’hème dans le processus crucial de la primo-colonisation. Mais cela autorise également à plus long terme d’envisager l’utilisation de ce système pour diminuer la quantité d’hème disponible dans l’intestin et donc son effet pro-inflammatoire, dans les maladies inflammatoires chroniques de l’intestin. / The intestinal microbiota comprises the numerous microorganisms colonizing the digestive tract. This flora, and the variations it undergoes are unique and specific to each individual. The microbial balance, which is a determinant of our state of health, develops gradually from birth. In addition to the known roles of the microbiote in digestion, it is now recognized as an important contributor to human metabolism. Among the 10¹³ bacteria inhabiting the human gut, the genus Bacteroides comprises the dominant genus, and is needed to digest complex dietary polysaccharide fibers. This feature, and the resistance to trace oxygen of these Gram-negative anaerobes make them particularly well adapted to the intestinal environment. Remarkably, although heme is a required metabolite for Bacteroides growth, these bacteria are incapable of heme synthesis. Heme, which comprises an iron atom trapped within a porphyrin ring, is a cofactor involved in numerous enzymatic reactions essential to central metabolism. Its bioactivity may also provoke intestinal inflammatory phenomena. We investigated the interactions between the bacterium Bacteroides thetaiotaomicron and environmental heme. We first developed a test to detect nanogram amounts of heme in complex media such as intestinal contents. We then showed that the commensal bacterium Escherichia coli donates heme to B. thetaiotaomicron in vitro. Nevertheless, we found that E. coli is not the major heme source for Bacteroides colonization, as tested in a germfree mouse model. This study led us to conclude that the host must be the major heme donor. We then set up a system to modulate heme availability in the digestive tract by capturing free heme on a hemophore HasA, from Serratia marcescens. We confirmed the HasA system was active in vitro. Preliminary experiments indicate that it 1- reduces levels of intestinal heme, and 2- delays B. thetaiotaomicron colonization. The present work provides tools for better understanding the factors needed for Bacteroides implantation in the gut and underlines the importance of heme in this crucial process of primocolonization. In the longer term, the bacterial heme-capture system may be considered as a means of decreasing free intestinal pools of heme and thereby its pro-inflammatory effect, in chronic inflammatory bowel diseases.

OpenAthens is a hosted identity and access management service that provides a streamlined solution for implementing single sign-on authentication. This presentation will outline the steps East Tennessee State University took to configure OpenAthens authentication across the Alma, Primo, and EZproxy platforms. We will give a brief overview of the internal configurations related to LDAP integration, allocating electronic resources, and selectively assigning permissions. Finally, we will share our experiences with OpenAthens including support, vendor adoption, and end user benefits.

[pt] Eça de Queirós pretendia moralizar a sociedade, construindo uma literatura que deveria funcionar como um espelho, no qual estaria refletido o quadro social português da segunda metade do século XIX. Assim, o autor criou cenas que acabam por mostrar que a própria sociedade tinha como base um jogo de encenações, com certas regras pré-estabelecidas. Luísa e Juliana, de O Primo Basílio, Pedro da Maia, Maria Monforte, Carlos Eduardo e Maria Eduarda de Os Maias são personagens que cometem transgressões, ou seja, não agem exatamente de acordo com o que era considerado moralmente correto. Nessa dissertação, objetivamos investigar as motivações que levam às transgressões e, ainda, as possíveis conseqüências desse desvio ao modelo social. / [en] Eça de Queirós aimed to improve the morals of Portuguese society through a sort of literature that was to function as a mirror reflecting the Portuguese way of life in the latter half of the 19th century. Thus the author portrayed Portugal as a society based on role-playing, following certain preestablished rules. Luísa and Juliana, in O Primo Basílio, Pedro da Maia, Maria Monforte, Carlos Eduardo and Maria Eduarda, in Os Maias, are characters who engage in transgression, deviating from what was considered moral. In this thesis we investigate the reasons that led to transgression of social rules, as well as the possible consequences of such deviant behavior.

Existeix una acusada tendència en el món historiogràfic a presentar la dictadura de Primo de Rivera com un règim polític monolític i uniforme, amb un únic discurs, sense a penes escletxes. La hipòtesi central de la nostra investigació es fonamenta en la idea que la realitat fou molt distinta, ja que dins el mateix Directori cohabitaren plantejaments substancialment diferents, que provocaren discrepàncies serioses en el si del règim. L'esmentada hipòtesi la intentem demostrar partint de l'anàlisi d'un aspecte concret, però molt important, de la Dictadura que és el que fa referència al propòsit de Primo de Rivera, al nostre entendre fracassat, de fonamentar gran part del seu projecte polític en el fet de desenvolupar una intensa tasca propagandística quehavia de servir per transmetre una bona imatge del règim i per inculcar ideologia. El marc territorial investigat és el format per les comarques gironines, on convergeixen tres factors decisius que aporten elements que ajuden a explicar el fracàs del projecte de Primo de Rivera. El primer de caràcter més general, però igualment constatable en l'àmbit gironí, és el relatiu a la mateixa política de premsa del dictador, que es caracteritza per la seva poca definició i per la seva pèssima aplicació. Els dos següents, més específics, incideixen en l'existència de diferents maneres d'entendre la reforma de l'Estat dins el primoriverisme, i en les lluites intestines i localistes entre bàndols ambiciosos de poder. / There is a marked trend in the historical world to present the dictatorship of Primo de Rivera as a monolithic and uniform political system, with a single speech, barely cracks. The central hypothesis of our research is based on the idea that the reality was very different because in the same directory substantially different approach coexisted, which caused serious disagreements within the regime. We attempt to demonstrate the above hypothesis on the basis of the analysis of a very important specific aspect of the dictatorship that makes reference to the purpose of Primo de Rivera, failed in our opinion, to substantiate much of its political project in developping an intense propaganda, that was supposed to transmit a good image of the regime and to instill ideology. The geographical area investigated is Girona region, where three crucial converging factors help to explain the failure of the project Primo de Rivera. The first one, more general, but also verifiable in the Girona area, is the dictator's press polici, which is characterized by its short definition and its terrible application. The two following, more specific, impact on the existence of different ways of understanding the State reform within primoriverism, and the localist infighting between ambitious factions eager for power.

Dans le sillage des guerres totales et des génocides du XXe siècle sont apparus des ouvrages d’un genre nouveau : les témoignages. Ils sont le fait d’hommes et de femmes survivants d’une violence politique extrême qui, endossant le rôle de témoins, ont entrepris de faire connaître leur expérience au plus grand nombre en rendant compte par écrit des sévices endurés. Leur mission : attester ce qu’ils ont vu et subi, rendre hommage aux disparus, initier un questionnement sur les mécanismes ayant conduit au meurtre de masse, et opposer aux tentatives de destruction de l’humain et de sa culture une réflexion sur le vivre-ensemble et la dissolution toujours possible des liens sociaux les plus fondamentaux. Le corpus légué par ces témoins constitue l’objet d’étude de cette thèse de doctorat, qui poursuit un double objectif : décrire, sur la base d’une lecture minutieuse des textes, partiellement assistée d’outils d’analyse textométriques, les principales caractéristiques du genre, et poser les jalons d’une histoire du témoignage et de sa réception, publique et critique, à partir de récits faisant état d’expériences aussi diverses que celles du feu pendant la Grande Guerre, de l’univers concentrationnaire sous le régime nazi et de la violence coloniale en Algérie. Comprendre ce qui spécifie génériquement ces textes au-delà de la diversité des œuvres et des événements dont elles sont issues, suppose de dégager le projet commun qui les sous-tend et les constitue en lignée, étant entendu qu’un genre ne se définit pas en fonction de critères ontologiques immuables. Il apparaît dans des circonstances socio-historiques précises, et se déploie à un niveau d’interférences sémiotiques qui justifie cette double approche, philologique et historique. / Books of a new kind appeared out of the total wars and genocides of the twentieth century – testimonies. They are written by male and female survivors of extreme political violence, who, taking on the role of witnesses, decided to share their experiences with others by writing of the suffering they had undergone. Their mission consists in testifying what they saw and experienced, paying tribute to those who did not survive, questioning the mechanisms which led to mass murder, and opposing to the attempts to destroy human beings and their culture a reflection about living together and the ever-present possibility of the most fundamental social relationships falling apart. The corpus left by these witnesses is the object of study of this PhD dissertation, which has two aims: to describe, based on a close reading of the texts, partially aided by the tools of textometric analysis, the main characteristics of the genre, and to create the basis of a history of testimonies and their public and critical reception, using accounts which reveal such diverse experiences as trench warfare during the World War One, the concentration camps of the Nazi regime, and colonial violence in Algeria. In order to understand the generic specificity of these texts going beyond the diversity of the works and the events they proceed, it is necessary to define the underlying common project which forms a tradition, given that a genre is not defined according to unchanging ontological criteria. It appears in precise socio-historical circumstances, and is situated at a level of semiotic interference which justifies this dual philological and historical approach.

(in English): The diploma thesis deals with the conceptual model functional requirements for bibliographic records and its implementation or FRBRisation of library information systems abroad. The introduction of the thesis presents in brief the FRBR conceptual model and its family. The second chapter discusses the development of FRBRisation activities since the creation of the FRBR study to the present. The third chapter presents a more detailed description of the FRBRisation process and presents the benefits and challenges of these projects. In connection with this, the impact on cataloging standards and data structures is also mentioned, as well as the currently debated issue concerning the possible ways of presenting the FRBRised data. The last chapter of the diploma thesis contains analysis and comparison of two selected FRBRised systems (BORéAL union catalog and Primo discovery system), with emphasis on the means and scope of FRBR implementation and user interface.