Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2015-12-07T19:57:51Z No. of bitstreams: 1 DanniellyAzevedoDeOliveira_DISSERT.pdf: 872333 bytes, checksum: e2aa62a84a4a1a65870ac0e5e6035dd6 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2015-12-10T20:06:22Z (GMT) No. of bitstreams: 1 DanniellyAzevedoDeOliveira_DISSERT.pdf: 872333 bytes, checksum: e2aa62a84a4a1a65870ac0e5e6035dd6 (MD5) / Made available in DSpace on 2015-12-10T20:06:22Z (GMT). No. of bitstreams: 1 DanniellyAzevedoDeOliveira_DISSERT.pdf: 872333 bytes, checksum: e2aa62a84a4a1a65870ac0e5e6035dd6 (MD5) Previous issue date: 2014-09-12 / A adolesc?ncia ? vista como uma fase da vida marcada por uma s?rie de transforma??es f?sicas e comportamentais, o que leva a determinada situa??es de risco, como o in?cio precoce da atividade sexual, a gravidez e a ocorr?ncia de doen?as sexualmente transmiss?veis. Baseado nessa afirma??o, a pesquisa objetivou de forma geral: conhecer o perfil sexual e reprodutivo das adolescentes de um servi?o de refer?ncia no munic?pio de Natal. De maneira espec?fica: descrever as caracter?sticas s?cioecon?micas, sexuais e reprodutivas individuais e familiares da popula??o em quest?o, como tamb?m, verificar poss?vel associa??o entre gravidez e idade de in?cio da atividade sexual com os aspectos socioecon?micos. O Estudo seccional realizado em banco de dados a partir dos registros de 463 adolescentes que buscaram atendimento num servi?o de refer?ncia em sa?de Sexual e Reprodutiva, no per?odo de mar?o de 2011 a junho de 2012. Os dados coletados foram submetidos ? an?lise realizada pelos programas Excel 2007 e Statiscal Package for the Social Sciences (SPSS) 17.0. Para an?lise dos dados foi utilizada a estat?stica descritiva, com n?meros absolutos e percentuais, sendo a sua apresenta??o feita por meio de tabelas de distribui??o e frequ?ncias. Os resultados mostraram que os pais dessas adolescentes (65,7% - pai; 57,8% - m?e), possu?am ensino fundamental; renda familiar inferior a dois sal?rios m?nimos (66,2%); algum tipo de depend?ncia qu?mica na fam?lia (33,5%) e presen?a de viol?ncia dom?stica (20,6%). Foi verificada ocorr?ncia de gravidez quando a m?e apresentava ensino fundamental (26,3%), outras pessoas que n?o o pai ou a m?e contribu?am com a renda familiar (33,3%) e (26%) quando havia depend?ncia qu?mica na fam?lia O in?cio precoce da atividade sexual foi observado quando a m?e apresentava ensino fundamental (57,3%), outras pessoas que n?o o pai ou a m?e contribu?am com a renda familiar (63,1%) e o uso de drogas/?lcool como um problema familiar (67,6%). Concluiu-se que tais vulnerabilidades aparecem como reflexo da baixa condi??o social dessas jovens, agravadas pela heran?a afetiva que ? ofertada a cada indiv?duo desde o nascimento. Estes achados poder?o qui??, subsidiar as pol?ticas p?blicas de vigil?ncia da sa?de ?s adolescentes em diversas ?reas. / Adolescence is seen as a phase of life marked by a series of physical and behavioral changes, which leads to certain risk situations, such as early sexual activity, pregnancy and the occurrence of sexually transmitted diseases. Based on this statement, this research aimed generally: meet the sexual and reproductive adolescents of a reference service in Natal profile. Specifically describe the socioeconomic, sexual and reproductive individual and family characteristics of the population in question, but also verify possible association between pregnancy and age of onset of sexual activity with the socioeconomic aspects. The sectional study conducted in the database from the records of 463 adolescents seeking care in a referral center in Sexual and Reproductive Health in the period March 2011 to June 2012. The data collected were subjected to analysis by Excel 2007 and Statistical Package for Social Sciences (SPSS) 17.0. For data analysis, descriptive statistics, with absolute numbers and percentages was used, and its presentation by means of distribution and frequency tables. Results showed that the parents of these adolescents (65.7% - father; 57.8% - mother), had primary education; family income less than two minimum wages (66.2%); any type of chemical dependency in the family (33.5%) and presence of domestic violence (20.6%). A higher probability of pregnancy was verified when the mother had only primary education (26.3%), persons other than the father or mother contributed to family income (33.3%) and (26%) when there was substance abuse in the family early onset of sexual activity was observed when the mother had primary education (57.3%), persons other than the father or mother contributed to family income (63.1%) and the use of drugs / alcohol as a problem family (67.6%). It was concluded that such vulnerabilities appear as a reflection of the low social status of these young people, aggravated by emotional inheritance that is offered to every individual from birth. These findings may perhaps, support public health surveillance policies for adolescents in several areas

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-01-14T20:53:43Z No. of bitstreams: 1 FrancijaneDinizOliveira_DISSERT.pdf: 2898520 bytes, checksum: dfced591976cc8757208d89ec6e92b7d (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-01-20T16:36:14Z (GMT) No. of bitstreams: 1 FrancijaneDinizOliveira_DISSERT.pdf: 2898520 bytes, checksum: dfced591976cc8757208d89ec6e92b7d (MD5) / Made available in DSpace on 2016-01-20T16:36:14Z (GMT). No. of bitstreams: 1 FrancijaneDinizOliveira_DISSERT.pdf: 2898520 bytes, checksum: dfced591976cc8757208d89ec6e92b7d (MD5) Previous issue date: 2014-05-09 / A proposta de integra??o ensino-servi?o a partir de viv?ncias no mundo do trabalho traz aos profissionais atuantes nos servi?os de sa?de um desafio, aliar a sua pr?tica assistencial ? prepara??o de novos profissionais em conformidade com o modelo de sa?de nacional. Na cidade de Recife-PE, a rede de assist?ncia ? conhecida como rede escola, pois disponibiliza para as Institui??es de Ensino Superior todos os seus equipamentos de sa?de e, em especial, os profissionais que l? trabalham para a pr?tica de preceptoria, transformando essa atividade em um componente importante da rede de servi?os. O presente estudo teve como objetivo analisar a experi?ncia da preceptoria junto as Resid?ncias Multiprofissionais em Sa?de da Fam?lia no olhar dos profissionais de sa?de. Trata-se de um estudo descritivo de natureza qualitativa, cujos participantes s?o m?dicos, odont?logos, enfermeiros que exerceram a preceptoria por no m?nimo dois anos nas Resid?ncias Multiprofissionais em Sa?de da Fam?lia vinculadas a duas Institui??es de Ensino Superior. Como instrumento de pesquisa, foi utilizada uma entrevista semiestruturada e os dados foram processados mediante o aux?lio do software Alceste 4.9. Os resultados apontaram quatro classes sem?nticas que emergiram do material textual, as quais foram divididas em dois eixos distintos: O Eixo 1, composto pela classe 4, e a Eixo 2, composto pelas classes 3, 2 e 1. A categoriza??o levou em considera??o a rela??o das classes entre si. Observou-se que a classe 4 apresenta a sobrecarga de trabalho como dilema da participa??o profissional na preceptoria, a perceber pelo jogo de palavras: conseguir, tempo, paciente, dar e complicado. Todavia, observa-se, tamb?m, que a preceptoria realiza a??es de ensino-aprendizagem positivas, refor?adas atrav?s das palavras dizer, explicar e discutir. A classe 2 mostra a preceptoria como troca de experi?ncia - momento positivo que propicia atualiza??o te?rica ao preceptor - associando ?s pr?ticas profissionais executadas pelo bin?mio preceptor-estudante em servi?os de sa?de e comunidades. Nessa perspectiva, todos s?o beneficiados, porque a preceptoria ? estruturada em torno dos aspectos din?micos do conhecimento, vivenciados em cen?rios permeados pelas necessidades de sa?de das pessoas. Na classe 3, aparecem as potencialidades desta experi?ncia; ela destaca o compromisso pessoal como o principal motivo da atua??o enquanto preceptor nesta rede de forma??o/aten??o, fundamentando-se nas palavras motivo, forma??o, gostar e profissionais. Por fim, por?m n?o menos importante, h? a classe 1, que sugere a import?ncia da preceptoria como uma das estrat?gias para efetivar a Pol?tica Nacional de Humaniza??o, a partir da integra??o ensino-servi?o-comunidade, a observar pelas palavras: chega, universidade, fundamental, maneira, parceria, servi?o e aluno, al?m de apontar as perspectivas e os desafios para a melhoria do exerc?cio da preceptoria nos servi?os de sa?de. A integra??o ensinoservi?o-comunidade pode potencializar as propostas de mudan?as relativas ao modelo de aten??o praticado nos servi?os, mas essa rela??o ainda ? superficial. O preceptor ? um ator em ato, trabalha na cena da vida real, e ? nesse momento que ele torna-se essencial para a busca de uma forma??o com o perfil defendido nas propostas de forma??o de um profissional que seja capaz de aprender a aprender / The proposal of teaching-service integration from work experience brings a challenge to the professionals involved in health services: to combine their healthcare practice to the preparation of new professionals in accordance with the national health model. In Recife, the assistance network is known as school network, since it provides all its health equipment for Higher Education Institutions, in special for professionals who work as preceptors, making this activity an important component of the services network. The objective of the present study was to analyze preceptorship experience herein Multidisciplinary Residences in Health in the look of health professionals. This is a qualitative descriptive study, involving physicians, dentists, and nurses that have worked as preceptors for at least two years in multidisciplinary residency linked to two Higher Education Institutions. A semistructured interview was used as research instrument and data were processed by using the software Alceste 4.9. Results indicated four semantic classes which were divided into two axis. Axis 1, composed of class 4, and Axis 2, composed of classes 3, 2 and 1. Categorization considered the relation between classes. It was observed that in class 4 work overload is a dilemma for professional participation in preceptorship. This is noted by the words manage, time, patient, give, and complicated. However, it is also observed that the preceptorship involves positive learning and teaching actions, reinforced by the words say, explain, and discuss. Class 2 shows the preceptorship as an experience exchange, a positive moment that provides theoretical upgrade to the preceptor, associated to the professional practices performed by the binominal preceptor-student in health services and communities. In this perspective, everyone is benefited since preceptorship is structured according to dynamic aspects of knowledge, experienced in settings permeated by people?s health necessities. In class 3, potentialities of this practice are shown, and personal compromise is the main reason of acting as a preceptor in this network of education/attention, demonstrated in the words reason, formation, to like and professionals. Last, but not the least, class 1 suggests the importance of preceptorship and one of the strategies to create the National Politics of Humanization, from the teachingservice-community integration, observed in the words: arrives, university, fundamental, manner, partnership, service, and student. Besides, it rates perspectives and challenges for the improvement of the preceptorship in health services. Integrating teaching and service can enhance the proposals of changes concerning the healthcare model practiced in services, but this relation is still superficial. The preceptor is an actor in action, playing real life roles, and that is when he becomes essential to seek training with the profile defended in the proposed training of a professional who is capable of learning to learn

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-03-10T22:56:02Z No. of bitstreams: 1 LorenaMarquesFerreira_DISSERT.pdf: 1448614 bytes, checksum: 493cfd5d28340ce79f9783f7d1e34cb5 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-03-18T19:29:08Z (GMT) No. of bitstreams: 1 LorenaMarquesFerreira_DISSERT.pdf: 1448614 bytes, checksum: 493cfd5d28340ce79f9783f7d1e34cb5 (MD5) / Made available in DSpace on 2016-03-18T19:29:08Z (GMT). No. of bitstreams: 1 LorenaMarquesFerreira_DISSERT.pdf: 1448614 bytes, checksum: 493cfd5d28340ce79f9783f7d1e34cb5 (MD5) Previous issue date: 2015-04-24 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / A an?lise cefalom?trica ? caracterizada pela mensura??o de grandezas lineares e angulares, por meio da demarca??o de pontos, dist?ncias e linhas em uma telerradiografia e ? considerada de fundamental import?ncia para o diagn?stico e planejamento ortod?ntico. Assim sendo, o objetivo desta pesquisa foi comparar grandezas cefalom?tricas obtidas por ortodontistas e radiologistas, a partir da an?lise de uma mesma telerradiografia, em um programa de an?lise cefalom?trica computadorizada. Todos os participantes da pesquisa demarcaram 18 pontos cefalom?tricos em um computador notebook com tela de 14 polegadas, conforme as instru??es fornecidas pelo pr?prio programa (Radiocef Studio 2 ? ). A partir da?, foram geradas 14 grandezas cefalom?tricas abrangendo par?metros esquel?ticos, dentoesquel?ticos, dent?rios e tegumentares. A fim de averiguar a concord?ncia intra-examinador, 10 profissionais de cada grupo repetiram a demarca??o dos pontos com um intervalo m?nimo de 8 dias entre as duas marca??es. A variabilidade intragrupo foi calculada com base nos coeficientes de varia??o (CV). J? a compara??o intergrupos foi realizada atrav?s do teste t de Student, para as vari?veis com distribui??o normal, e atrav?s do teste de Mann-Whitney, para aquelas com distribui??o n?o normal. No grupo dos ortodontistas, as grandezas Pog e 1-NB, SL, Linha S-Ls, Linha S-Li e 1.NB apresentaram elevada variabilidade interna. No grupo dos radiologistas, o mesmo ocorreu com as grandezas Pog e 1-NB, Linha S-Ls, Linha S-Li e 1.NA. Na compara??o entre os grupos, todas as grandezas lineares analisadas e duas angulares apresentaram diferen?a estatisticamente significativa entre radiologistas e ortodontistas (p<0,05). De acordo com os resultados, o erro interexaminador na an?lise cefalom?trica requer maior aten??o, mas n?o adv?m de uma classe espec?fica de especialistas, sejam eles ortodontistas ou radiologistas. / Cephalometric analysis is the mensuration of linear and angular measures through demarcation points as distances and lines on teleradiography, and is considered of fundamental importance for diagnosis and orthodontic planning. In this manner, the objective of this research was to compare cephalometric measurements obtained by dentists and radiologists from the analysis of the same radiograph, in a computerized cephalometric analysis program. All research participants marked 18 cephalometric points on a 14-inch notebook computer, as directed by the program itself (Radiocef 2?). From there, they generated 14 cephalometric parameters including skeletal, dental-skeletal, dental and soft tissue. In order to verify the intra-examiner agreement, 10 professionals from each group repeated the marking of the points with a minimum interval of eight days between the two markings. The intra-group variability was calculated based on the coefficients of variation (CV). The comparison between groups was performed using the Student t-test for normally distributed variables, and using the Mann-Whitney test for those with non-normal distribution. In the group of orthodontists, the measurements of Pog and 1-NB, SL, S-Ls Line, S-Li Line and 1.NB showed high internal variability. In the group of radiologists, the same occurred with the values of Pog and 1-NB, S-Ls Line, S-Li Line and 1.NA. In the comparison between groups, all the analyzed linear values and two angular values showed statistically significant differences between radiologists and dentists (p <0.05). According to the results, the interexaminer error in cephalometric analysis requires more attention, but does not come from a specific class of specialists, being either dentists or radiologists.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-06-15T19:06:24Z No. of bitstreams: 1 AverlandioWallyssonSoaresDaCosta_DISSERT.pdf: 779907 bytes, checksum: b401dfa05e4b39aa356396d66e91181f (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-06-20T20:25:34Z (GMT) No. of bitstreams: 1 AverlandioWallyssonSoaresDaCosta_DISSERT.pdf: 779907 bytes, checksum: b401dfa05e4b39aa356396d66e91181f (MD5) / Made available in DSpace on 2016-06-20T20:25:34Z (GMT). No. of bitstreams: 1 AverlandioWallyssonSoaresDaCosta_DISSERT.pdf: 779907 bytes, checksum: b401dfa05e4b39aa356396d66e91181f (MD5) Previous issue date: 2015-12-15 / O envelhecimento como um fen?meno social pauta-se nos modos de produ??o e reprodu??o, que atrelados a peculiaridades e conformidades da estrutura social influenciam nos valores e sentidos erguidos. A busca pelo entendimento da realidade dar-se-? pela apropria??o do conhecimento/informa??o, que na contemporaneidade cada vez mais s?o atrelados aos meios midi?ticos, de forma que esses ultrapassam a condi??o de meros meios de comunica??o, chegando a condi??o de instrumentos de produ??o direta de valores, posturas e opini?es. Dentre os instrumentos midi?ticos, tem-se os meios jornal?sticos, que s?o importantes meios de dissemina??o de informa??o e consequentemente de produ??o de sentidos, inclusive sobre o envelhecimento. Assim, de forma geral objetiva-se: conhecer as representa??es da m?dia acerca do envelhecimento, tendo como foco jornais circulantes no Rio Grande do Norte. Aliado ao objetivo geral, elegem-se como espec?ficos: apreender os fatores que possam influenciar nesse processo; e refletir sobre os entendimentos estabelecidos sobre o envelhecimento. Para tanto valer-se-? da Teoria da Representa??o Social. Para coleta dos dados, foram estudadas 57 not?cias online dos tr?s principais jornais do estado, quais sejam: Tribuna do Norte, Gazeta do Oeste e Jornal de Hoje, que foram captadas atrav?s de instrumento de busca dos s?tios dos pr?prios jornais, utilizando os termos de busca: ?envelhecimento?, ?idoso?. Essas mat?rias foram analisadas valendo-se da An?lise de Conte?do Tem?tica de Bardin, que permitiu o estabelecimento de cinco categorias, a saber: Envelhecimento e viol?ncia; Envelhecimento na contemporaneidade; Envelhecimento e sa?de; Envelhecimento e cidadania; e Envelhecimento, trabalho e a??o. Na primeira categoria s?o enquadradas not?cias que denunciam situa??es violentas, que independente da condi??o de v?tima ou acusado pela viol?ncia, a fragilidade do idoso persiste. Em Envelhecimento na contemporaneidade percebeu-se as tentativas da m?dia jornal?stica em explicar as mudan?as demogr?ficas do aumento quantitativo de idosos, os ?nus que isso pode gerar para o pleno desenvolvimento do pa?s. No Envelhecimento e sa?de ? percebido a condi??o de fim iminente trazido no envelhecer, como sin?nimo de doen?as e debilidades. Na quarta categoria, Envelhecimento e cidadania, s?o visualizados situa??es em que peculiaridades e necessidades dos idosos precisam virar obriga??o para serem cumpridas, denunciando condi??o de baixa express?o e poder social da classe. Por fim, em Envelhecimento, trabalho e a??o s?o trazidas situa??es que denunciam a n?o expectativa do idoso a intera??o com as novas tecnologias e participa??o nos rumos decis?rios da sociedade. De forma geral e espec?fica tal an?lise permitiu apreender os modos de produ??o de sentidos sobre envelhecimento pelos jornais, j? que esses tendem a representar o envelhecimento por meio de situa??es intencionadas, conforme necessidades hegem?nicas, construindo a representa??o social do idoso como um ser fr?gil, submisso, inativo, pass?vel ? viol?ncia e suscept?vel ao adoecer. / Aging as a social phenomenon is guided in the ways of production and reproduction, that is linked to the peculiarities and compliances of the social structure influence the values and erected senses. The search for the understanding of the reality will be given by the appropriation of knowledge/information that in contemporary times are increasingly tied to the media means, so that they go beyond the mere condition media, reaching the condition of instruments of direct, attitudes and opinions production. Among the media instruments, there are news medias, that are important means of information dissemination and consequently production of senses, including over aging. Thus, the objective is to: apprehend the social representations and meanings associated with aging in the media space about aging; browse the social representations about aging in media space and their influence on the relations that are established in the cultural socio-economic context. To do it The Theory of Social Representation will be used. To collect the data, 57 online news from the three main state newspapers were studied: Tribuna do Norte, Gazeta do Povo and Jornal de Hoje, which were captured through a search tol of these newspaper sites, using the words: ?aging??elderly?. These materials were analyzed making use of Bardin?s Qualitative Analysis, which allowed the establishment of five categories, namely: Aging and violence; Aging in contemporary times; Aging and health; Aging and citizenship; and Aging, work and action. In the first category news reporting violent situations are framed the regardless of the victim?s condition or the one charged by the violence, the fragility of elderly persists. In Aging in contemporary times the attempts of the news media to explain the demographic changes of the quantitative increases in the elderly, the burden it may lead to the full development of the country are noticed. In Aging and health is noticed the imminent end of the condition brought on age, as a synonym for diseases and conditions. In the fourth category, Aging and citizenship situations are shown where peculiarities and needs or the elderly need to turn into obligation to be fulfilled, denouncing the condition of low expression and social power of the class. Finally, in Aging, work and action situations that indicate the non-expectation of elderly interaction with new technologies and participation in decision-making directions of society are brought. In a general and specific form this analysis allowed learning the ways of production of meanings about aging in the papers, as these ones tend to represent aging through intentioned situations as hegemonic needs, building the social representation of the elderly as fragile person, submissive, inactive, subject to violence and susceptible to becoming ill.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-02-02T14:33:26Z No. of bitstreams: 1 HelicarlosBatistaDeMorais_DISSERT.pdf: 1562953 bytes, checksum: 9d4f3c123ecc57b12aab4eed13855262 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-02-09T16:56:04Z (GMT) No. of bitstreams: 1 HelicarlosBatistaDeMorais_DISSERT.pdf: 1562953 bytes, checksum: 9d4f3c123ecc57b12aab4eed13855262 (MD5) / Made available in DSpace on 2017-02-09T16:56:04Z (GMT). No. of bitstreams: 1 HelicarlosBatistaDeMorais_DISSERT.pdf: 1562953 bytes, checksum: 9d4f3c123ecc57b12aab4eed13855262 (MD5) Previous issue date: 2016-08-31 / A doen?a periodontal representa um grupo de les?es imuno-inflamat?rias que afetam tanto os tecidos de prote??o como os de sustenta??o dos dentes. Seu principal agente etiol?gico ? o biofilme bacteriano, contudo a destrui??o do tecido periodontal ? provocada principalmente pela resposta exacerbada do sistema imunol?gico do hospedeiro. Estudos recentes evidenciam o efeito anti-inflamat?rio e antioxidante dos f?rmacos antidiab?ticos orais pertencentes ? classe das sulfonilur?ias sobre algumas doen?as inflamat?rias. O objetivo desse trabalho foi avaliar a a??o da gliclazida (GLI), um antidiab?tico oral que vem apresentando efeito anti-inflamat?rio e antioxidante, sobre a doen?a periodontal em ratos que foram induzidos atrav?s de ligadura. Utilizou-se 125 ratos da ra?a wistar que foram distribu?dos aleatoriamente em 5 grupos com 25 animais cada: (NL) n?o foi submetido a indu??o da doen?a periodontal, mas recebeu solu??o salina; (L) Foi submetido a indu??o da doen?a periodontal e recebeu solu??o salina; (GLI 1mg) Foi submetido a indu??o da doen?a periodontal e recebeu GLI 1 mg/kg; (GLI 5mg) Foi submetido a indu??o da doen?a periodontal e recebeu GLI 5 mg/kg; e (GLI 10mg) Foi submetido a indu??o da doen?a periodontal e recebeu GLI 10 mg/kg. Os grupos foram tratados com solu??o salina (NL e L) ou GLI (GLI 1, GLI 5 e GLI 10mg) por gavagem durante o per?odo de 10 dias. Ap?s a eutan?sia dos animais, que ocorreu no d?cimo primeiro dia, os tecidos periodontais foram removidos e passaram pelas seguintes an?lises: morfom?trica, histopatol?gica, imuno-histoqu?mica, glutationa (GSH), PCR em tempo real (RT-PCR), malonalde?do (MDA) e mieloperoxidase (MPO). Notou-se que o tratamento com GLI 1 mg/kg foi capaz de reduzir o MDA (p <0.05), IL-1? (p <0.05), TNF-? (p <0.05) e MPO (p <0.05). Reduziu ainda a express?o de MMP-2, RANK, RANKL, catepsina K, SOD e elevou a express?o de OPG. Tendo ainda a dose de GLI 1mg/kg de forma simult?nea diminu?do a express?o de NF-?B p65, de Pl3K e tamb?m do AKT em compara??o ao grupo L (p <0.01). Esses resultados denotam que a GLI na dosagem de 1mg/kg conseguiu apresentar a??o anti-inflamat?ria na doen?a periodontal induzida, pois diminuiu os efeitos da perda ?ssea alveolar, promoveu a redu??o dos n?veis de citocinas pr?-inflamat?rias e aumentou a express?o de agentes anti-inflamat?rios. / Periodontal disease is a group of immuno inflammatory diseases that have the potential to affect both the protective fabrics as support teeth, the principal etiologic agent is bacterial biofilm, but the destruction of periodontal tissue is primarily caused by excessive response the host immune system. Recent studies show anti-inflammatory and antioxidant effect of oral antidiabetic drugs belonging to the sulfonylurea class of some inflammatory diseases. The aim of this study was to evaluate the action of gliclazide (GLI), an oral antidiabetic which has shown anti-inflammatory and antioxidant effect on periodontal disease in rats that were induced by ligation. We used 125 Wistar rats were randomly divided into 5 groups of 25 animals each: (NL) inducing periodontal disease has not been submitted but received saline solution; (L) has undergone induction of periodontal disease and received saline; (GLI 1mg) inducing periodontal disease GLU has been made and received 1 mg / kg; (GLI 5mg) was subjected to induction of periodontal disease GLU and received 5 mg / kg; and (GLI 10mg) was subjected to induction of periodontal disease GLU and received 10 mg / kg. The groups were treated with saline (NL and L) or GLI (1 GLY, GLY GLY 5 and 10mg) over a period of 10 days. After sacrificing the animals, which occurred on the eleventh day, the periodontal tissues were removed and passed the following tests: morphometric histopathologic, immunohistochemical, glutathione (GSH), real-time PCR (RT-PCR), malondialdehyde (MDA) and myeloperoxidase (MPO). It is noted that treatment with GLI 1 mg / kg was able to reduce the MDA (p <0.05) IL-1? (p <0.05), TNF-? (p <0.05) and MPO (p <0.05). also decreased MMP-2 expression, RANK, RANKL, cathepsin K, SOD and increased OPG expression. Still in the dose GLI 1mg / kg simultaneously reduced NF-?B p65 expression of AKT Pl3K and also compared to the L group (p <0.01). These results show that the GLI dosage of 1mg / kg could provide the anti-inflammatory action induced periodontal disease because the effects of decreased alveolar bone loss, caused a reduction in the levels of pro-inflammatory cytokines and increase expression of anti-agents inflammatory.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-02-02T14:33:26Z No. of bitstreams: 1 LiviaMariaDeAzevedo_DISSERT.pdf: 1401266 bytes, checksum: e711e670cfddfc04f72de6124077ab1a (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-02-09T17:10:06Z (GMT) No. of bitstreams: 1 LiviaMariaDeAzevedo_DISSERT.pdf: 1401266 bytes, checksum: e711e670cfddfc04f72de6124077ab1a (MD5) / Made available in DSpace on 2017-02-09T17:10:06Z (GMT). No. of bitstreams: 1 LiviaMariaDeAzevedo_DISSERT.pdf: 1401266 bytes, checksum: e711e670cfddfc04f72de6124077ab1a (MD5) Previous issue date: 2016-06-30 / A ideia de que envelhecer acarreta v?rias doen?as cr?nicas, perdas da autoestima, da beleza exterior, dos reflexos e da mem?ria ainda permanece na sociedade. A falta de conhecimento sobre o envelhecimento, refor?ado ao culto ? juventude ? o suficiente para se formarem estere?tipos e preconceitos contra essas pessoas. Este tipo de discrimina??o chama-se velhismo. Diante desse contexto, o presente trabalho objetivou verificar a ocorr?ncia do velhismo e os fatores a ele relacionados na realidade de idosos n?o institucionalizados. Trata-se de um estudo transversal, com uma abordagem quantitativa, envolvendo 188 indiv?duos com 60 anos ou mais de idade que foram escolhidos por conveni?ncia em uma amostragem por cotas. Utilizou-se para a coleta de dados um question?rio contendo o perfil demogr?fico, econ?mico, social, de sa?de e o Mapa M?nimo de Rela??es do Idoso, al?m do instrumento Ageism Survey traduzido e adaptado, utilizado para verificar a ocorr?ncia do velhismo. No tratamento dos dados foi realizada a caracteriza??o da amostra por meio da an?lise descritiva, depois obteve-se as poss?veis associa??es significativas atrav?s do teste Qui quadrado (p<0,20), e em seguida, foi feita a an?lise multivariada pela regress?o log?stica (p<0,05). Foi encontrado quanto a vari?vel ?sofreu algum tipo de discrimina??o? que os idosos com menor n?mero de comorbidades foram mais discriminados do que os mais doentes. O mesmo aconteceu com o idoso que ? respons?vel pela sua pr?pria casa, o qual sofre mais discrimina??o do que aquele que tem algum filho ou parente como respons?vel. O que usa transporte p?blico tamb?m sofre mais velhismo do que o que n?o usa, assim como quem tem mais tempo de aposentadoria em rela??o a quem tem menos tempo. Da mesma forma, os idosos que tiveram mais filhos foram mais v?timas do velhismo, e as mulheres idosas sofrem mais discrimina??o do que os homens. Em rela??o a vari?vel ?gravidade do velhismo?, os idosos que n?o recebem apoio emocional ou recebem de algu?m que n?o seja da fam?lia sofrem a forma mais grave de velhismo quando comparado ?queles que recebem apoio emocional de pelo menos um membro da fam?lia. Percebeu-se tamb?m que ter 4 filhos ou mais e ser do sexo feminino s?o fatores para sofrer o velhismo de forma mais grave. Com os resultados apresentados, observou-se o quanto o velhismo ? frequente e est? generalizado para a maioria dos idosos entrevistados, estando relacionado principalmente ?s suas condi??es de vida e de sa?de. Essa situa??o se agrava ? medida que se observa o desconhecimento da popula??o, inclusive a idosa, sobre este tipo de discrimina??o, al?m da gravidade e os problemas que ela pode acarretar. / The idea that aging causes various chronic diseases, loss of self-esteem, the outer beauty, reflexes and memory still remains in society. The lack of knowledge about aging, reinforced the cult of youth is enough to form stereotypes and prejudices against them. This kind of discrimination is called ageism. In this context, this study aimed to verify the occurrence of ageism and factors related to it in the reality of non-institutionalized elderly. This is a cross-sectional study with a quantitative approach, involving 188 individuals aged 60 years or older who were chosen for convenience in a sample by quotas. It was used for data collection a questionnaire containing demographic, economic, social and health profile and Map Minimum Relations Aging beyond the Ageism Survey instrument translated and adapted, used to check the occurrence of ageism. In the treatment of data was performed to characterize the sample by means of descriptive analysis, then gave the possible significant associations with the chi square test (p <0.20), and then was made a multivariate analysis by logistic regression ( p <0.05). It was found as the variable "suffered some kind of discrimination" that elderly patients with fewer comorbidities were more discriminated against than the sickest. The same happened to the old man who is responsible for his own house, which suffers more discrimination than one that has a son or relative responsible. Who uses public transportation also suffers more ageism than that does not use, as well as those who have more time for retirement compared to those who have less time. Similarly, older people had more children were more ageism victims, and older women suffer more discrimination than men. Regarding the variable "severity of ageism," the elderly who do not receive emotional support or receive from someone other than family suffer the most severe form of ageism when compared to those who receive emotional support from at least one family member. It was also perceived to have four or more children and being female are factors to suffer the ageism more severe form. With the results, it was observed how the ageism is common and is generalized to the majority of elderly respondents, and were primarily related to their living conditions and health. This situation worsens as observing the ignorance of the population, including the elderly, this kind of discrimination, in addition to gravity and the problems it can cause.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-02-13T20:32:59Z No. of bitstreams: 1 SandersonJoseCostaDeAssis_DISSERT.pdf: 1457110 bytes, checksum: a2f40e65a54dc23c294ada1cfe5c48f5 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-02-16T21:39:04Z (GMT) No. of bitstreams: 1 SandersonJoseCostaDeAssis_DISSERT.pdf: 1457110 bytes, checksum: a2f40e65a54dc23c294ada1cfe5c48f5 (MD5) / Made available in DSpace on 2017-02-16T21:39:04Z (GMT). No. of bitstreams: 1 SandersonJoseCostaDeAssis_DISSERT.pdf: 1457110 bytes, checksum: a2f40e65a54dc23c294ada1cfe5c48f5 (MD5) Previous issue date: 2016-08-01 / Introdu??o: A escoliose ? caracterizada por altera??es tridimensionais da coluna vertebral, onde se tem uma inclina??o lateral no plano frontal, juntamente com rota??o contralateral no plano transversal e retifica??o no plano sagital. Os escolares constituem-se como um grupo de risco para essa deformidade por passarem pela fase de estir?o de crescimento, associada a outros fatores como longa perman?ncia da postura sentada, suporte de mochilas escolares de maneira assim?trica e/ou com excesso de peso do material escolar, uso de cal?ados inapropriados, dentre outros. Considerando a escassa literatura abordando os fatores de risco para a escoliose, este estudo tem por objetivo analisar os fatores de risco para a escoliose em escolares. Metodologia: A pesquisa foi de car?ter observacional, do tipo caso-controle, com abordagem quantitativa realizada no munic?pio de Santa Cruz/RN. Foi avaliada a presen?a de escoliose, bem como atividade f?sica, pr?tica esportiva competitiva e h?bitos posturais, a fim de identificar fatores de risco para a escoliose. Foi utilizada a regress?o log?stica m?ltipla condicional e foram estimadas as Odds Ratios (OR) e os respectivos intervalos de confian?a (95%) da vari?vel desfecho e adotado um n?vel de signific?ncia de 5%. Resultados: participaram da pesquisa 78 pares, totalizando 156 escolares, sendo 86 meninas e a m?dia de idade de 13,88 anos. Na regress?o log?stica condicional, na an?lise bivariada a pouca pr?tica de atividade f?sica mostrou-se como fator de risco para a escoliose (p=0,041; OR: 2,81; IC95%: 1,04-7,57), enquanto que as demais vari?veis n?o apresentaram signific?ncia estat?stica. Conclus?o: A baixa atividade f?sica apresentou-se como fator de risco para escoliose em escolares, podendo indicar a pr?tica de atividade f?sica como fator protetor para escoliose. / Introduction. Scoliosis is characterized by three-dimensional, with deviations in the sagittal, coronal, and horizontal planes. School constitute them as a risk group for this deformity by going through the growth spurt phase of growth, coupled with other factors such as sitting for long periods of time, asymmetric straps on school backpacks and/or backpacks overloaded with school supplies, the use of inappropriate footwear, and other factors. Considering the limited literature addressing the risk factors for scoliosis, this study aims to analyze the risk factors for scoliosis in school. Methodology. This is a case-control study in schoolchildren of Santa Cruz a Northeastern city in Brazil. We evaluated the presence of scoliosis, physical activity, competitive sports practice and postural habits. In order to identify factors risk with scoliosis, were estimated odds ratio (OR) and confidence intervals (95%) were estimated by means of conditional multiple logistic regression. A significance level of 5% was used. Results. Seventy-eight pairs participated in the study, totaling 156 students, including 86 girls and the average age of 13.88 years. In conditional logistic regression, physical activity bivariate analysis showed statistical significance (p = 0.041) showing that those who practiced little physical activity (irregularly active) have more risk of having scoliosis when compared with active children (OR: 2.64; 95% CI: 1.18 to 5.89), however when compared with sedentary school there was no statistical significance (p = 0.893). This significance remained in the adjusted model, to be set by competitive sports practice and backpack transport. The other variables were not statistically significant. Conclusions. Low physical activity is presented as a risk factor for scoliosis in school and may indicate a physical activity as a protective factor for scoliosis.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-10-05T00:11:28Z No. of bitstreams: 1 IsabeleDosAnjosPaivaDosSantos_DISSERT.pdf: 2151672 bytes, checksum: c4799b98339ff9d09b70ff660d6c91d2 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-10-16T22:50:59Z (GMT) No. of bitstreams: 1 IsabeleDosAnjosPaivaDosSantos_DISSERT.pdf: 2151672 bytes, checksum: c4799b98339ff9d09b70ff660d6c91d2 (MD5) / Made available in DSpace on 2017-10-16T22:50:59Z (GMT). No. of bitstreams: 1 IsabeleDosAnjosPaivaDosSantos_DISSERT.pdf: 2151672 bytes, checksum: c4799b98339ff9d09b70ff660d6c91d2 (MD5) Previous issue date: 2017-03-14 / A presta??o de um servi?o de qualidade deve estar associada com o compromisso quanto ? seguran?a do paciente e para isso ? imprescind?vel compreender a complexidade do processo de trabalho em sa?de. A enfermagem, em especial, ? uma profiss?o que enla?a todos os aspectos relativos ? qualidade dos servi?os de sa?de, uma vez que desenvolve atividades assistenciais e gerencias, al?m de assumir os cuidados com o paciente por maior tempo e com mais proximidade que os demais profissionais envolvidos nesse processo de trabalho. Por essa raz?o, destaca-se a import?ncia de se refletir sobre seu processo de trabalho no sentido de apontar o caminho para uma assist?ncia em sa?de segura e com qualidade. Nesse sentido, a presente pesquisa objetiva analisar a rela??o entre seguran?a do paciente e enfermagem em um ambiente hospitalar a partir da reflex?o sobre seu processo de trabalho. Trata-se de uma pesquisa de abordagem qualitativa do tipo descritivo e explorat?rio, utilizando a t?cnica da entrevista semi-estruturada. Foram entrevistados 20 profissionais de enfermagem lotados em um hospital p?blico de grande porte, sendo 5 enfermeiros e 15 t?cnicos de enfermagem. As informa??es foram analisadas ? luz da t?cnica da an?lise tem?tica, compreendida dentro do m?todo de an?lise de conte?do. Ap?s organizar os n?cleos de significados pelas semelhan?as sem?nticas, foram constru?das duas categorias: Categoria 1: Considera??es sobre seguran?a do paciente e a Categoria 2: Rela??o entre a enfermagem e seu trabalho: a prop?sito do processo de trabalho. Pode-se inferir que a qualidade da assist?ncia de enfermagem produz um forte impacto na seguran?a do paciente, o que remete a necessidade de compreender a rela??o que h? entre a enfermagem e seu trabalho como um aspecto importante para o enfrentamento dos problemas de uma assist?ncia insegura. / The provision of a quality service should be associated with a commitment to patient safety and for this it is imperative to understand the complexity of the health work process. Nursing, in particular, is a profession that encompasses all aspects related to the quality of health services, since it develops care activities and management, besides taking care of the patient for a longer time and with more proximity than other professionals Involved in this work process. For this reason, it is important to reflect on the work process in order to point the way to safe and quality health care. In this sense, the present research aims to analyze the relationship between patient safety and nursing in a hospital environment based on the reflection about their work process. It is a qualitative research of the descriptive and exploratory type, using semi-structured interview techniques. Twenty nursing professionals were interviewed in a large public hospital, 5 nurses and 15 nursing technicians. The information was analyzed in light of the thematic analysis technique, included within the content analysis method. After organizing the nuclei of meanings for the semantic similarities, two categories were constructed: Category 1: Considerations about patient safety and Category 2: Relationship between nursing and its work: about the work process. It can be inferred that the quality of nursing care has a strong impact on patient safety, which points to the need to understand the relationship between nursing and its work as an important aspect for coping with problems of unsafe care Insecure.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-10-05T00:11:28Z No. of bitstreams: 1 LorenaDeSouzaAraujo_DISSERT.pdf: 7643028 bytes, checksum: 6b215a3176b087904cc8a05dd18daa3b (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-10-16T23:17:41Z (GMT) No. of bitstreams: 1 LorenaDeSouzaAraujo_DISSERT.pdf: 7643028 bytes, checksum: 6b215a3176b087904cc8a05dd18daa3b (MD5) / Made available in DSpace on 2017-10-16T23:17:41Z (GMT). No. of bitstreams: 1 LorenaDeSouzaAraujo_DISSERT.pdf: 7643028 bytes, checksum: 6b215a3176b087904cc8a05dd18daa3b (MD5) Previous issue date: 2017-07-21 / A Mucosite Oral (MO) ? uma das principais complica??es envolvidas no tratamento do c?ncer, em especial, da regi?o de cabe?a e pesco?o. Trata-se de uma inflama??o que afeta a mucosa da cavidade oral e se caracteriza clinicamente pelo surgimento de les?es eritematosas, ulceradas e dolorosas, o que pode ocasionar, em casos mais graves, interrup??o do tratamento quimioter?pico. O objetivo deste estudo foi avaliar o efeito da Olmesartana (Olme), um antagonista do receptor AT1 da angiotensina II (Ang II), na mucosite oral. Foi realizado um ensaio pr?-cl?nico, in vivo, randomizado, cego, com utiliza??o de grupos controles. 42 hamsters Golden Siriam foram divididos em 6 grupos: Controle, Trauma Mec?nico, 5-FU, Olme 1mg/kg, Olme 5mg/kg e Olme 10mg/kg. Nos grupos doentes a MO foi induzida nos dois primeiros dias do experimento com um quimioter?pico, o 5-fluorouracil (5-FU, 60 mg/kg dia 1 e 40 mg/kg dia 2). Os animais foram pr?-tratados com Olme oral (1, 5, ou 10 mg/kg) ou ve?culo (controles) 30 min antes da inje??o de 5-FU e diariamente at? o d?cimo dia. As amostras de mucosa da bochecha foram submetidas a an?lise macrosc?pica, histopatol?gica, an?lise de atividade enzim?tica bioqu?mica e imunohistoqu?mica. Rea??es em cadeia de polimerase de transcriptase reversa (RT-PCRs) foram utilizadas para quantificar a express?o de NF-?B, p65, PI3K e MKP1. Os n?veis de ?xido n?trico sintase induz?vel (iNOS) e quinase regulada extracelularmente (ERK) foram analisados com Western Blot. O tratamento com 10 mg/kg de Olme reduziu os n?veis de ulcera??o, mieloperoxidase (MPO) e malonalde?do (MDA), inflama??o celular, edema e hemorragia (todos p <0,05). O tratamento com Olme de 10 mg/kg tamb?m reduziu os n?veis do fator de necrose tumoral (TNF)-?, interleucina (IL)-1?, aumentando a express?o PI3K e diminuindo a express?o de NFKB, p65, MKP1 e diminuindo os n?veis de iNOS e ERK1/2. A utiliza??o da Olme na dose de 10 mg/kg reduziu o dano e a inflama??o da mucosa associados com a MO induzido por 5-FU. / Oral Mucositis (MO) is one of the main complications involved in the treatment of cancer, especially in the head and neck region. It is an inflammation that affects the mucosa of the oral cavity is clinically characterized by erythematous, ulcerated and painful lesions, Which can lead, in more severe cases, to an interruption of chemotherapy treatment. The aim of this study was to evaluate the effect of Olmesartan (Olme), an angiotensin II (Ang II) receptor antagonist, on oral mucositis. A pre-clinical trial was performed, in vivo, randomized, blind, with use of control groups. 42 Golden Siriam hamsters were divided into 6 groups: Control, Mechanical Trauma, 5-FU, Olme 1mg/kg, Olme 5mg/kg and Olme 10mg/kg. In the diseased groups MO was induced on the first two days of the experiment with a chemotherapeutic, 5- fluorouracil (5-FU, 60 mg / kg day 1 and 40 mg / kg day 2). Animals were pretreated with oral Olme (1, 5, or 10 mg/kg) or vehicle (control) 30 min before 5-FU injection and daily until day 10. Cheek pouch samples were subjected to histopathologic analysis, protein/immunology analysis, and immunoistochemistry. Reverse transcriptase polymerase chain reactions (RT-PCRs) were used to quantitate expression of NF- ?Bp65, PI3K, and MKP1. Inducible nitric oxide synthase (iNOS) and extracellular regulated kinase (ERK)1/2 levels were analysed with immunoblots. Treatment with 10 mg/kg Olme reduced ulceration, myeloperoxidase (MPO) and malonaldehyde (MDA) levels, cellular inflammation, edema, and hemorrhage (p<0.05). The 10 mg/kg Olme treatment also reduced tumour necrosis factor (TNF)-?, interleukin (IL)-1?, increasing expression PI3K, and decreasing expression of NFKBp65, MKP1, and decreasing iNOS and ERK1/2 levels. Olme at a dose of 10 mg/kg prevented the mucosal damage and inflammation associated with 5-FU? induced OM.

Orientador: Carlos Alonso B. de Oliveira / Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Economia / Made available in DSpace on 2018-07-23T03:56:34Z (GMT). No. of bitstreams: 1 Maffezoli_LineuCarlos_D.pdf: 28504124 bytes, checksum: 4e98d1d402d0afb73a5b932e4d59e398 (MD5) Previous issue date: 1997 / Resumo: Não informado / Abstract: Not informed. / Doutorado / Doutor em Economia