Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-02-17T18:33:30Z No. of bitstreams: 1 EtienneAndradeDeMedeirosDantas_TESE.pdf: 2817576 bytes, checksum: 7bf94f009e046d5a0802babde9a93ef3 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-02-17T19:55:48Z (GMT) No. of bitstreams: 1 EtienneAndradeDeMedeirosDantas_TESE.pdf: 2817576 bytes, checksum: 7bf94f009e046d5a0802babde9a93ef3 (MD5) / Made available in DSpace on 2017-02-17T19:55:48Z (GMT). No. of bitstreams: 1 EtienneAndradeDeMedeirosDantas_TESE.pdf: 2817576 bytes, checksum: 7bf94f009e046d5a0802babde9a93ef3 (MD5) Previous issue date: 2016-09-26 / A presente tese de doutorado teve por objetivo geral investigar as compet?ncias na forma??o e pr?tica profissional do tecn?logo em constru??o de edif?cios. Nesse contexto, a pesquisa contribuiu para a discuss?o acerca da natureza de compet?ncias e habilidades requeridas para ocupa??es profissionais historicamente caracterizadas como predominantemente pr?ticas, no sentido de fundadas em saberes pr?ticos, extra-acad?micos e pragm?ticos (saber-fazer), em contraste com compet?ncias simb?lico-formais fundadas em saberes formais-conceituais (saber-dizer). A tese encontra-se fundamentada na perspectiva da psicologia hist?rico-cultural e amparada pela proposta te?rico-metodol?gica da Cl?nica da Atividade. A pesquisa foi realizada com egressos, professores e gestores do Curso Superior de Tecnologia em Constru??o de Edif?cios. Para atingimento dos objetivos esperados adotou-se a combina??o de m?todos quantitativos e qualitativos de produ??o e an?lise dos dados. Na etapa quantitativa, aplicou-se um question?rio socioprofissional, obtendo-se o retorno de 41(quarenta e um) participantes. A an?lise dos dados quantitativos foi realizada atrav?s de estat?stica descritiva uni e multidimensional, complementada por an?lise estat?stica inferencial. Na etapa qualitativa, realizou-se consulta a documentos oficiais de natureza pedag?gica, entrevistas semi-dirigidas com professores e gestores do curso e, por fim, as entrevistas de Instru??o ao S?sia (IaS) com egressos. Esta etapa foi executada atrav?s de an?lise cl?nico-interpretativa, tendo por base a perspectiva hist?rico-cultural vigotskiana e a abordagem social das compet?ncias e habilidades. Os resultados analisados permitiram constatar que os profissionais s?o, na maioria jovens (m?dia de idade de 26 anos e 06 meses), 58,6% do sexo feminino, 58,5% solteiros e somente 19,5% tem filhos. Tamb?m averiguou-se que a profiss?o de tecn?logo em constru??o de edif?cios tem servido como est?gio preliminar ou caminho de passagem em dire??o a outra forma??o e ocupa??o profissional, ?quela de engenheiro civil. As principais compet?ncias requeridas do tecn?logo em constru??o de edif?cios recobrem os dom?nios da gest?o, projetos e or?amento. Conclui-se que a ocupa??o profissional do tecn?logo em constru??o de edif?cios apresenta uma forma??o s?lida e atualizada com as demandas do mercado de trabalho, havendo concatena??o entre os conhecimentos te?ricos e pr?ticos em fun??o das estrat?gias pedag?gicas utilizadas durante o processo de forma??o profissional, segundo avalia??o dos sujeitos participantes. No entanto, ainda tem sua ?rea de especificidade estabelecida notadamente em rela??o aos engenheiros civis. Por esta raz?o, percebe-se que h? uma necessidade de consolida??o da identidade profissional do tecn?logo em constru??o de edif?cios junto ?s entidades regulamentadoras da profiss?o e ao mercado de trabalho. / The present doctorate research aimed to investigate competencies in training and professional practice of technologists in building construction. The research contributed in this context to the discussion about the nature of competencies and skills required for professional occupations historically characterized as predominantly practical, founded on practical, extraacademic and pragmatic knowledge (know-what), in contrast to symbolic-formal competencies based on formal and conceptual knowledge (know-how). The thesis is based on the perspective of the historical-cultural psychology and supported by theoretical and methodological proposals of Clinic of Activity. The survey was conducted with certified professionals (former students), teachers and managers participating in the Course of Technology in Building Construction. A combination of quantitative and qualitative methods of production and data analysis was adopted for achievement of expected goals. A socioprofessional survey was applied in the quantitative step, 41 (forty one) participants having returned the on-line questionnaire. The quantitative data analysis was performed using descriptive uni and multidimensional statistic methods, completed by inferential statistical analysis. Official pedagogical documents were inspected in the qualitative stage, what was completed by semi-structured interviews with teachers and managers and Instruction to the Double interviews with professionals. This step was based on clinical and interpretative analysis, based on the cultural-historical Vygotskian perspective and the social approach to competencies and skills. Results allowed verifying that professionals are mostly young (average age of 26 years and 06 months), 58.6% of participants being female, 58.5% single and only 19.5% having children. It was also verified that the profession of technologist in construction of buildings is considered as a preliminary stage or passageway toward other training and professional occupations, especially civil engineering. The main competencies required from technologist in construction of buildings encompass areas of management, project and budget. Final conclusion stresses that the occupation of technologist in construction of buildings has a solid background in terms of formation, connected to demands of the labor market and based on theoretical and practical knowledge issued from previous training process, according to the evaluation of participants. However, this professional occupation is still referred to civil engineering. For this reason, a need for consolidation of professional identity of technologist in building construction by the regulators of the professional activity and by the labor market is required.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-06-13T19:26:36Z No. of bitstreams: 1 WalberCunhaLima_TESE.pdf: 4065084 bytes, checksum: 340a6aa11a6ba30a874dd0dd9d99d1ae (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-06-16T19:53:36Z (GMT) No. of bitstreams: 1 WalberCunhaLima_TESE.pdf: 4065084 bytes, checksum: 340a6aa11a6ba30a874dd0dd9d99d1ae (MD5) / Made available in DSpace on 2017-06-16T19:53:36Z (GMT). No. of bitstreams: 1 WalberCunhaLima_TESE.pdf: 4065084 bytes, checksum: 340a6aa11a6ba30a874dd0dd9d99d1ae (MD5) Previous issue date: 2017-02-21 / Estuda-se a mistan?sia enquanto um neologismo bio?tico consistente em uma morte infeliz e sofrida de in?meras pessoas provocada por situa??es de desigualdade decorrentes de sistemas que desfavorecem a vida e contribuem para disseminar uma cultura excludente e mort?fera. Constata-se que apesar de acontecimentos hist?rico-mistan?sicos impulsionarem o surgimento do movimento bio?tico norte-americano hegem?nico, este n?o possui uma dimens?o social, mas individualista e direcionada para interesses cl?nico-biotecno-cient?ficos, e verifica-se que, ao se exclu?rem das suas aprecia??es quest?es decorrentes da injusti?a e desigualdade social, o paradigma hegem?nico bio?tico ?Made in USA?, globalmente difundido, favorece contexto para a eclos?o de Escolas Bio?ticas contra-hegem?nicas brasileiras, as quais abordam em seus debates dilemas macrossociais ressonantes com a realidade perif?rica latina e propiciam espa?o para inclus?o da mistan?sia nas reflex?es bio?ticas. Para o debate te?rico de tais quest?es, a pesquisa respalda-se em aportes de um pensamento bio?tico-jur?dico cr?tico e concebe-se, como proposta de tese, o enfrentamento do fen?meno mistan?sico a partir desse pensamento contextualizado com o processo de empoderamento-liberta??o-emancipa??o dos sujeitos sociais. Destaca-se a proje??o acad?mica da Bio?tica Social com a promulga??o da Declara??o Universal sobre Bio?tica e Direitos Humanos e indaga-se como, juntos, a bio?tica e os direitos humanos poderiam se constituir em instrumento de interven??o nos fatos geradores da mistan?sia. No campo emp?rico, vislumbra-se a multiplicidade de elementos suscitadores da mistan?sia e elege-se, dentre eles, a viol?ncia para investig?-la, sendo este o recorte dado na presente investiga??o, a qual tem como objetivo delinear o perfil da v?tima brasileira no per?odo compreendido entre 2005 a 2014. Para responder ao questionamento formulado, perfaz-se uma revis?o de conjunto da literatura bio?tica contra-hegem?nica, conjugada a uma concep??o cr?tico-dial?tica dos direitos humanos, ao tempo em que se realiza, como estrat?gia de investiga??o, pesquisa qualitativa para obten??o de informa??es dos ?bitos por viol?ncia no Brasil em sites oficiais, e desenvolve-se an?lise interseccionalizada a partir dos dados coletados, tendo-se como categorias a cor/etnia, o g?nero/sexo, idade e n?vel de alfabetiza??o das v?timas da viol?ncia por Unidade Federativa do Brasil. Como resultado, ap?s an?lise dos dados nacionalmente obtidos, identifica-se que o perfil da v?tima brasileira da mistan?sia relativa ? viol?ncia provem do nordeste brasileiro, configura-se como sendo masculina, negra, alfabetizada e com idade compreendida entre 15 e 29 anos. Conclui-se que, atrav?s das conflu?ncias entre as reflex?es bio?ticas de cunho social e os direitos humanos concebidos sob uma perspectiva cr?tica, aliada ? consci?ncia participativa dos atores sociais, poder? ser viabilizada uma exist?ncia humana digna, afastada de fatores que conduzem ? mistan?sia, inibindo-a. / Misthanasia is studied as a consisting bioethical neologism of an unhappy and suffering death of countless people caused by situations of inequality arising from systems that disfavor life and contribute to spread an excluding and deadly culture. It is observed that although the historical-misthanasics events stimulate the emergence of the hegemonic North American bioethical movement, it does not have a social dimension, but individualistic and directed towards clinical-biotechnology-scientific interests and it is verified that, by excluding it from their appreciation issues arising from injustice and social inequality, the bioethical hegemonic paradigm "Made in USA", globally diffused, favors the context for the outbreak of the Brazilian counter-hegemonic Bioethical Schools, which approach in their debates, resonant macrossocial dilemmas in Latin American peripheral reality and provide space for the inclusion of misthanasia in bioethical reflections. For the theoretical debate of such questions, the research is based on contributions of a critical bioethical-legal thinking and it is conceived, as a thesis proposal, the confrontation of the misthanasic phenomenon from this contextualized thought with the process of empowerment-liberation-emancipation of social subjects. The academic projection of Social Bioethics is highlighted with the promulgation of the Universal Declaration on Bioethics and Human Rights and investigates how, bioethics and human rights could constitute an instrument of intervention in the generative events of misthanasia. In the empirical field, the multiplicity of elements that provoke misthanasia is glimpsed, and among those elements, violence is chosen to be investigated. That is the field of the present research which aims to outline the profile of the Brazilian victim from 2005 to 2014. In order to respond to the questioning formulated, a review of the whole counterhegemonic bioethical literature is done, allied to a critical-dialectical conception of human rights, and takes place, at the same time, as a strategy research, a qualitative research to obtain information on official sites of death rates from violence in Brazil. Also, an intersectional analysis is developed based on the data collected, using as categories, color/ethnicity, gender/sex, age and literacy level of victims of violence occurred in every Brazilian Federative Unit. As a result, after analyzing the nationally obtained data, it is identified that the profile of the Brazilian victim of misthanasia related to violence in the Brazilian Northeast is male, black, literate and aged between 15 and 29 years. It is concluded that, through the confluences between bioethical reflections of a social nature and human rights conceived in a critical perspective, allied to the participatory awareness of social actors, a dignified human existence can be made possible inhibiting the factors which lead to misthanasia.

A alta competitividade e os avanços tecnológicos propiciaram o surgimento de um novo modelo de terceirização de Tecnologia de Informação (TI), os Provedores de Serviços de Aplicativos (ASP - Application Service Providers). A proposta do modelo ASP é a comercialização de aplicativos de software como serviço. A satisfação dos clientes está diretamente relacionada à qualidade do serviço prestado. Para garantir que sejam fornecidos serviços com qualidade, é fundamental a adoção dos Acordos dos Níveis de Serviços (SLA - Service Levei Agreements) como mecanismo de controle. No entanto, são escassas as informações formalizadas que venham a contribuir com a especificação desses acordos. Propondo-se a contribuir com a compreensão de SLA para ASP, apresenta-se uma pesquisa exploratória do conceito de SLA para ASP, de modelos de qualidade e dos fatores de qualidade a serem considerados nos SLA para garantir a qualidade dos serviços prestados. / lhe current competitiveness of the global market and the continuous technological evolution pushed the risen of a new model of Information Technogy Outsourcing, the Application Service Providers (ASP). The ASP modelproposes the remote delivery of software as a service. Therefore, customers\' satisfaction is strictelly related to the quality of ser\\>ice delivered. It is highly recommended the adoption of Service Levei Agreement (SLA) as a control mechanism to assure such quality of service. However, there is a lack of formalized statements regarding the specification of these agreements. As a matter of contribution for the compreension of the SLA for ASP, this work introduces an exploratory research of the concep of SLA for ASP, and of the quality models and quality metrics to be considered by the SLA to assure the quality of the services provided.

Sociala konsekvensanalyser är en process som handlar om att beskriva, analysera och hantera avsiktliga och oavsiktliga sociala konsekvenser som uppkommer som en följd av planerad stadsutveckling. Syftet med studien är att skapa ökad kunskap kring teori och praktik i sociala konsekvensanalyser genom att jämföra teorier om social rättvisa och aktuell forskning med ett praktiskt exempel i anslutning till infrastrukturprojektet “Västlänken” i Göteborg. Studien kommer även att undersöka om det finns några eventuella utmaningar i den praktiska tillämpningen av sociala konsekvensanalyser. Vidare syftar studien till att få insikt i på vilket sätt en social konsekvensanalys potentiellt kan påverka social rättvisa. Resultatet visar att det förekommer utmaningar kring en gemensam förståelse och definition av området, avsaknad av en gemensam modell samt en brist på kompetens inom social hållbarhet och social rättvisa. Studien föreslår att det införs ett lagkrav på sociala konsekvensanalyser och utformning av en nationell modell med utgångspunkt i teorier om social rättvisa. Att inkludera sociala konsekvensanalyser i planeringsprocessen innebär att ta ställning till ett antal komplexa frågor, nödvändiga för att nå fram till ett rättvist och socialt hållbart samhälle. / Impact Assessments are common tools in urban planning, used to predict future consequences of a certain project. This study focuses on the Social Impact Assessment, which is about the processes of describing, analyzing and managing the intended and unintended social consequences of planned interventions. The purpose of the study is to create an understanding of the theory and practice in Social Impact Assessments and in what way the Social Impact Assessment could have the potential to affect social justice. This will be accomplished by comparing existing research within the subject and theories about social justice with the Social Impact Assessment carried out in an infrastructure project called "Västlänken" in Gothenburg, Sweden. The study also explores if there are any particular challenges in the field of Social Impact Assessments and its practical application. The results show that there are challenges around the common understanding and definition of the field, absence of a common model and a lack of expertise in social sustainability and social justice. The study proposes that the Social Impact Assessment becomes a legal requirement in Sweden and that a national model based on theories of social justice will be created. Including Social Impact Assessments in the planning process means taking a stand in a variety of difficult questions, necessary in the aim for a just and socially sustainable society.

La scoliose est la déformation de la colonne vertébrale la plus répandue. Elle atteint 3 à 4% de la population pédiatrique et dans 85% des cas, aucune cause n’a été identifiée. Ces cas sont appelés idiopathiques et les symptômes apparaissent durant la puberté; d’où le terme de ‘scoliose idiopathique de l’adolescent (SIA). Cette pathologie atteint le plus souvent les jeunes filles, en nombre et en sévérité. Ces dernières années, plusieurs hypothèses ont été proposées afin d’élucider l’étiologie de cette pathologie. Celles-ci ont mis de l’avant différents facteurs génétiques, biochimiques, mécaniques, neurologiques, musculaires ou hormonaux. Plusieurs études ont rapporté des formes familiales de scoliose, soutenant la thèse d’une prédisposition génétique. Nous avons démontré que les patients souffrant de SIA présentent un défaut de signalisation cellulaire médiée par les protéines Gi et un taux élevé d’ostéopontine (OPN) circulante. En utilisant une approche de type ‘gène candidat’, nous avons montré que la protéine tyrosine phosphatase μ (PTPμ) régule l’activité du complexe d’intégrines α5/β1 (récepteur de l’OPN) via la protéine kinase PIPKIγ. Dans ce but, nous avons utilisé des cultures primaires d’ostéoblastes issues de biopsies de patients et de cas traumatiques comme sujets contrôles. Les biopsies osseuses de patients ont été obtenues lors de l’intervention chirurgicale à partir des vertèbres T3 à L4, selon les différentes procédures. Les biopsies issues de cas traumatiques proviennent d’autres types d’os (tibia, crête iliaque, fémur). Les profils d’expression du gène PTPRM (codant pour la protéine PTPμ) ont été étudiés par PCR quantitative (qPCR). Les taux de protéines PTPμ ont été analysés par immunoprécipitation suivi d’un western blot. Pour évaluer le rôle de cette protéine, nous avons bénéficié d’un modèle murin. Machida et al. ont démontré qu’il existe un taux plus élevé de scoliose parmi les souris C57Bl/6 bipèdes obtenues suite à l’amputation des membres supérieurs, sous anesthésie, cinq semaines après la naissance. Nous avons utilisé des cultures primaires d’ostéoblastes issues de la colonne ii vertébrale de souris C57Bl/6 bipèdes, délétées du gène PTPRM (souris dites ‘KO’), afin d’évaluer le niveau de signalisation cellulaire spécifique des protéines Gi par un test fonctionnel: la technique de spectroscopie cellulaire di-électrique (SCD). Selon nos données, 85% des souris bipédales ‘KO’ pour le géne PTPRM développent une scoliose (modérée à sévère) contre 55% des souris contrôles C57Bl6 bipèdes. De plus, les niveaux de PTPμ exprimée par les ostéoblastes de 34 patients SIA se trouvent diminués par comparaison à 17 sujets contrôles. Nos études de souris bipèdes ont montré que l’inactivation du gène PTPRM augmente l’incidence et la sévérité de la scoliose, sans pour autant affecter les taux circulant d’OPN ou l’expression de ses récepteurs. Par ailleurs, dans ce même contexte, nous avons remarqué une augmentation de l’interaction entre l’OPN et l’intégrine β1 en l’absence du gène PTPRM. Les cellules issues de ces souris bipèdes KO montrent une réduction dans leurs niveaux de signalisation cellulaire médiée par les protéines Gi après stimulation par l’OPN. Cette diminution est en grande partie récupérée après traitement des cellules par un siRNA spécifique de la protéine PIPK1γ, substrat de PTPμ qui favorise la fixation de ligands aux intégrines. Ces études apportent les premières indications que la perte d’expression de PTPμ est impliquée dans le développement de la SIA, en amplifiant probablement l’effet inhibiteur de l’OPN sur la signalisation cellulaire médiée par les protéines Gi. Ces études permettent une meilleure compréhension de l’étiologie de la SIA. Elles pourraient avoir une contribution importante dans le développement futur de méthodes diagnostique et thérapeuthique dans le but d'arrete l’apparition et l’évolution de la maladie chez les enfants atteints. / Adolescent idiopathic scoliosis (AIS) is the most common form of scoliosis that affects 3-4% of the global pediatric population. In more than 85% of cases, no specific cause can be identified. Such cases are called idiopathic and occur mostly during adolescence. AIS affects mainly females in number and severity. Over the past years, many hypotheses were proposed to explain the etiology of AIS, including genetic, biochemical, mechanics, neurological, muscular and hormonal factors. Several studies have reported a high incidence of scoliosis in some families, which argues for a genetic cause of this disease. We demonstrated that AIS patients have a Gi protein signaling defect and exhibit high levels of circulating Osteopontin (OPN). The goal of this thesis is to identify the mechanisms regulating OPN signaling activity in AIS patients. We have used a candidate gene driven approach and discovered that protein tyrosine phosphatase μ (PTP μ) regulates α5β1 integrin (a known OPN receptor) through phosphate kinase type 1 gamma (PIPK1γ). To achieve our goal, we have used primary osteoblast cell cultures derived from AIS patients and biopsies from control subjects. Bone specimens were obtained intraoperatively from vertebras (varying from T3 to L4 according to the surgical procedure performed) while with trauma cases used as non-scoliotic controls, bone specimens were obtained from other anatomical sites (tibia, femur or iliac crest). Expression profiles of the RPTPM gene (encoding for PTPμ) were studied by qPCR. On the other hand, PTPμ protein levels were determined by immunoprecipitation followed by western blot. To evaluate the role of this protein in AIS etiopathogenesis, we took advantage of an animal model exhibiting a higher scoliosis incidence when maintained in a bipedal state. [1], [2] Bipedal surgeries were performed on C57Bl/6 mice after weaning (5-weeks after birth) by amputation of the forelimbs and tail under anesthesia as reported by Oyama et al. (2006). [1] We used the same approach with PTPμ knockout mice and primary osteoblast culture were derived from the spine of these mice to assess Gi protein signaling through a functional assay termed Cellular Dielectric Spectroscopy (CDS). Bipedal PTPμ knockout mice develop scoliosis more often (85%) in number and severity, than control C57Bl/6 bipedal mice (55%). Interestingly, functional analysis of osteoblasts derived from PTPμ KO mice by CDS method showed a flaw in the transmission of Gi protein coupled receptor signaling similar to a specific AIS patient subgroup. Furthermore, the clinical relevance of PTPμ was strengthened by the fact that a decrease in the gene expression level of PTPμ was observed in 34 AIS patients when compared to 17 control subjects. Such a decrease was also confirmed at the protein level. We demonstrated that genetic deletion of PTPμ enhances the incidence and severity of scoliosis without affecting plasma levels of OPN or the expression of its receptors. In contrast, increased interaction of OPN with β1 integrin was noticed in cells depleted of PTPμ. Furthermore, reduction of Gi- protein coupled receptor GiPCR signaling by OPN was also enhanced in these cells, while their response to GiPCR stimulation was improved with siRNA of phosphatidylinositol-phosphate kinase type 1 gamma (PIPK1γ), a PTPμ substrate that favours ligand binding to integrins. These studies provide the first indication that the loss of PTPμ influences the nature of idiopathic scoliosis, possibly by amplifying the inhibitory effect of OPN on GiPCR signaling. This study allows a better understanding of AIS etiology and could have an impact for the future development of innovative diagnostic methods and eventual pharmacological approaches in order to prevent AIS and stop its progression in affected children.

Processos de fotodegradação de compostos orgânicos tóxicos têm sido bastante estudados. Este trabalho trata da aplicação do processo foto-Fenton para a degradação de atrazina em água (composto modelo). O efeito das concentrações dos seguintes compostos foi avaliado: peróxido de hidrogênio (2 a 6 mmol L-1) e ferrioxalato de potássio (0,2 a 1 mmol L-1). Os experimentos foram realizados em um reator com lâmpada UV - 8W (254nm). O processo de fotodegradação foi monitorado por medidas de espectrofotometria de absorção molecular automatizada por injeção seqüencial (SIA) para determinação de peróxido de hidrogênio e por cromatografia a líquido de alta eficiência (CLAE) para determinação de atrazina e metabólitos. Os experimentos demonstram que o processo de foto-Fenton é viável para o tratamento de atrazina em água. / Photo-degradation processes of toxic organic compounds have been widely studied. This work describes the application of the photo-Fenton process for degradation of atrazine in water. Atrazine was used as a model compound. The effects of the concentration of the following substances were evaluated: hydrogen peroxide (1 to 6 mmol L-1) and potassium ferrioxalate (0.2 to 1 mmol L-1). The experiments were accomplished in a reactor with an 8W UV lamp at 254 nm. The photo-degradation was monitored by molecular absorption spectrophotometry automated by sequential injection analysis (SIA) for determination of hydrogen peroxide and by high performance liquid chromatography (HPLC) for determínation of atrazine and its metabolites. Experimental results demonstrated that the photo-Fenton process is feasíble for the treatment of atrazine.

Submitted by PPG Direito (ppgdir@pucrs.br) on 2018-06-04T13:38:03Z No. of bitstreams: 1 Andrei_Ferreira_de_Arau?jo_Lima_DIS.pdf: 2336908 bytes, checksum: 566fe92260d6a118f2a36da3cfd3cc73 (MD5) / Approved for entry into archive by Sheila Dias (sheila.dias@pucrs.br) on 2018-06-11T13:15:40Z (GMT) No. of bitstreams: 1 Andrei_Ferreira_de_Arau?jo_Lima_DIS.pdf: 2336908 bytes, checksum: 566fe92260d6a118f2a36da3cfd3cc73 (MD5) / Made available in DSpace on 2018-06-11T13:29:04Z (GMT). No. of bitstreams: 1 Andrei_Ferreira_de_Arau?jo_Lima_DIS.pdf: 2336908 bytes, checksum: 566fe92260d6a118f2a36da3cfd3cc73 (MD5) Previous issue date: 2018-03-27 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / This work is the result of an interdisciplinary study between the Science of Law and Bioethics. It aims to understand the ethical and legal limits of the possible right to die, specifically euthanasia. In order to achieve that goal, we will investigate the conflict and the conformation between the fundamental right to life, to human dignity and the autonomy of the will, taking into account both doctrine and national and international jurisprudence. The main reason for the reincorporation of the subject of euthanasia into the medical and legal debate (both academic and jurisprudential) refers to the fast-moving and efficient evolution of medical science, developing treatments that can prolong the patient?s life, possibly, depending on the sickness, forever. In face of this reality, one can perceive the alteration of certain paradigms of Bioethics, such as the breaking of the paternalistic relationship between doctor and patient, the principle of beneficence according to what would be best for the patient, and the removal of unreasonable obstinacy, based on the autonomy of the will and in human dignity. In this scenario, the patients? rights are increasingly debated and new contour to the state?s duty to protect life are being given, especially when in conflict with the dignity and autonomy of the patient. In this scenario, it?s debated a possible right to die with dignity. This right promotes numerous questions, especially concerning the ethical and legal limits in cases of euthanasia, requiring the establishment of clear criteria, having as a basic principle the maximum protection of the patient?s dignity. It is emphasized that, in spite of the varied forms of assisted death, as well as the recent incorporation of ortotan?sia (term in Portuguese used for terminal patients who decline useless treatments and have their right to die granted) as legal conduct in medical ethics in Brazil, the work seeks to solve questions related to euthanasia. First classifying it, in order to avoid any form of semantic confusion. In the following points it will be discussed as a possible establishment of legal criteria as well as the practical developments, taking into account both the medical deontology and the patient?s fundamental rights. / O presente trabalho de disserta??o ? fruto de um estudo interdisciplinar entre a Ci?ncia do Direito e a Bio?tica, buscando compreender quais s?o os limites ?ticos e jur?dicos relativos a um poss?vel direito ? morte, especificamente ? eutan?sia. Para tanto, se investigar? o conflito e a conforma??o entre os direitos fundamentais ? vida, ? dignidade e ? autonomia, levando em considera??o tanto a doutrina quanto a jurisprud?ncia nacional e internacional. Elucida-se que o principal motivo para a reincopora??o da tem?tica da eutan?sia no debate m?dico e jur?dico (tanto em n?vel acad?mico quanto jurisprudencial), se refere ? r?pida e eficaz evolu??o da ci?ncia m?dica, desenvolvendo tratamentos que possam prolongar a vida de um paciente, por vezes, de modo ad eternum. Frente a essa realidade, se percebe a gradativa altera??o de determinados conceitos da Bio?tica, como a quebra da rela??o paternalista entre m?dico e paciente, o princ?pio da benefic?ncia de acordo com o que seria melhor para o paciente, e o afastamento da obstina??o irrazo?vel, todos calcados na autonomia da vontade e na dignidade da pessoa humana. Nesse cen?rio, os direitos dos pacientes s?o cada vez mais debatidos e o dever de prote??o da vida por parte do Estado passa a receber novos contornos, impondo-se limites ? dimens?o objetiva do direito fundamental ? vida, podendo prevalecer, em casos espec?ficos, a dimens?o subjetiva desse mesmo direito. Dessa rela??o entre vida, dignidade e autonomia, fala-se em um poss?vel direito ? morte digna. Contudo, restam in?meras quest?es quanto aos limites desse direito, tanto em um sentido ?tico quanto jur?dico, pois por mais que se conclua pela exist?ncia de um direito ? morte, necess?rio ser? o estabelecimento de crit?rios, limitando a autonomia dos pacientes, tendo como norte a prote??o m?xima de sua dignidade. Frisa-se que, em que pesem as mais variadas formas de morte assistida, bem como a recente incorpora??o da ortotan?sia como conduta legal na ?tica m?dica brasileira, o trabalho buscar? resolver quest?es relacionadas ? eutan?sia. Primeiro classificando-a, de modo a evitar qualquer forma de confus?o sem?ntica, para nos pontos seguintes estabelecer os crit?rios jur?dicos, bem como os desdobramentos pr?ticos calcados na deontologia m?dica.

Submitted by Ana Hilda Fonseca (anahilda@ufba.br) on 2014-09-05T15:25:03Z No. of bitstreams: 1 Dissertação LeandrodMF.pdf: 1496532 bytes, checksum: a3f1f8effe11a679e223ba5bdceeeb54 (MD5) / Approved for entry into archive by Fatima Cleômenis Botelho Maria (botelho@ufba.br) on 2014-09-05T15:56:02Z (GMT) No. of bitstreams: 1 Dissertação LeandrodMF.pdf: 1496532 bytes, checksum: a3f1f8effe11a679e223ba5bdceeeb54 (MD5) / Made available in DSpace on 2014-09-05T15:56:02Z (GMT). No. of bitstreams: 1 Dissertação LeandrodMF.pdf: 1496532 bytes, checksum: a3f1f8effe11a679e223ba5bdceeeb54 (MD5) / CNPq / Neste trabalho foi proposto um sistema de análises por injeção sequencial (SIA) para determinação espectrofotométrica da capacidade antioxidante em amostras de bebidas, a partir da geração “in situ” do radical derivado do reagente N-fenil-1,4-fenilenodiamino (NFFD•+). O radical NFFD•+ foi produzido em linha pela oxidação do NFFD empregando o Fe3+ como oxidante. Na otimização do sistema SIA foram avaliados os seguintes parâmetros: ordem de aspiração dos reagentes e amostra, estabilidade da solução de NFFD, pH da amostra, proporção NFFD/Fe3+, volumes das soluções dos reagentes e amostra e tempo de interrupção do fluxo. O ácido gálico foi empregado como padrão de calibração para os ensaios. Após as etapas de otimização univariada do método proposto obteve-se faixa linear de 10 a 40 mg L-1, com limites de detecção (3σ) de 1,0 mg L-1 e quantificação (10σ) de 3,3 mg L-1, respectivamente. Para avaliar o método proposto, foram realizados testes de reatividade do radical NFFD•+ frente a compostos fenólicos, tiólicos e de outra natureza. A redução do sinal analítico frente a inibição do radical derivado do NFFD foi mais pronunciada para ácido ascórbico, ácido tânico e cisteína, nesta ordem. A capacidade antioxidante com o radical derivado do NFFD foi avaliada em amostras de vinhos e chás, e os resultados foram concordantes com os métodos de referência (Folin-Denis, ABTS e DPPH), de acordo com o coeficiente de correlação, além do ensaio com radical DMPD•+, baseado no teste t. Assim a amina NFFD por ser utilizada para avaliação da atividade antioxidante em amostras de bebidas. Adicionalmente, as amostras de vinhos foram submetidas a testes de estabilidade temporal e avaliação do efeito do processo de ozonização em relação à variação da capacidade antioxidante / In this work was proposed a sequential injection system for spectrophotometric determination of antioxidant capacity in beverage samples with “in situ” radical generation from N-phenyl-1,4-phenylenediamine (NFFD•+). The radical NFFD•+ was produced by on line oxidation of NFFD employing Fe3+ as oxidant. The optimization of SIA system evaluated: aspiration order of reagents and sample, stability of the NFFD solution, sample pH, NFFD/Fe3+ proportion, reagents and sample volumes and stopped flow time. The gallic acid was used as standard of antioxidant compound for proposed sequential injection method. After chemical and physical univarieted optimization the linear range obtained in gallic acid concentration was from 10 to 40 mg L-1, with detection (3σ) and quantification (10σ) limits of 1.0 and 3.3 mg L-1, respectively. To evaluate selective of radical, studies of reactivity were performed with NFFD•+ and phenolic and thiol molecules and others compounds. The reducing capacity of NFFD•+ radical was observed preferentially for ascorbic acid, tannic acid and cysteine in this order. The antioxidant capacity with NFFD•+ radical was measured in samples of wines, infusions and teas. The results were agreement with the references methods (Folin-Denis, ABTS and DPPH), in accord with correlation coefficient, and additionally with the radical DMPD•+, based on t test. This way, the SIA spectrophotometric method exploring the radical NFFD•+ can be employed for the antioxidant capacity measured. Additionally, temporal stability and the ozonization effect in wine samples were evaluated using antioxidant capacity as parameter .

Processos de fotodegradação de compostos orgânicos tóxicos têm sido bastante estudados. Este trabalho trata da aplicação do processo foto-Fenton para a degradação de atrazina em água (composto modelo). O efeito das concentrações dos seguintes compostos foi avaliado: peróxido de hidrogênio (2 a 6 mmol L-1) e ferrioxalato de potássio (0,2 a 1 mmol L-1). Os experimentos foram realizados em um reator com lâmpada UV - 8W (254nm). O processo de fotodegradação foi monitorado por medidas de espectrofotometria de absorção molecular automatizada por injeção seqüencial (SIA) para determinação de peróxido de hidrogênio e por cromatografia a líquido de alta eficiência (CLAE) para determinação de atrazina e metabólitos. Os experimentos demonstram que o processo de foto-Fenton é viável para o tratamento de atrazina em água. / Photo-degradation processes of toxic organic compounds have been widely studied. This work describes the application of the photo-Fenton process for degradation of atrazine in water. Atrazine was used as a model compound. The effects of the concentration of the following substances were evaluated: hydrogen peroxide (1 to 6 mmol L-1) and potassium ferrioxalate (0.2 to 1 mmol L-1). The experiments were accomplished in a reactor with an 8W UV lamp at 254 nm. The photo-degradation was monitored by molecular absorption spectrophotometry automated by sequential injection analysis (SIA) for determination of hydrogen peroxide and by high performance liquid chromatography (HPLC) for determínation of atrazine and its metabolites. Experimental results demonstrated that the photo-Fenton process is feasíble for the treatment of atrazine.

The construction industry has an increased focus on using sustainable methods to reach a more sustainable society but is still lacking the social aspect of sustainability. The belief is that this aspect has to be a natural part in construction projects to successfully plan and develop sustainable societies. A method to achieve this could be the use of Social Impact Assessment (SIA), a method frequently used in other countries such as U.S, Australia and Canada. The aim with the thesis is to investigate how this method can be used in a Swedish context, but also how the public in the best manner can be involved in decisions that affect them. To complement the theory with empirical findings a case study is done within Järvalyftet, one of the biggest redevelopment projects in the Stockholm region at the moment. A SIA deals with several areas and issues and is therefore complex to perform in an efficient way. It is consequently important to create a team with mixed disciplines to be able to manage the work and face the different problems in the best possible way. The thesis indicates that public involvement is of major importance to create an acceptance for the planned project among the affected parties in order to reduce both the timeframe and the costs of the project. Further, the thesis indicates that public involvement early on in a project facilitates for the affected people to deal with changes and trade-offs resulting by the project. / Byggbranschen har idag ett större fokus på att använda hållbara metoder i byggandet för att på så sätt nå ett mer hållbart samhälle, men saknar fortfarande fokus på den sociala aspekten inom hållbarhet. För att lyckas med att planera och bygga hälsosamma och hållbara samhällen måste de här aspekterna bli en naturlig del i byggprojekten. En metod för att lyckas med detta kan vara användandet av Social Konsekvensbeskrivning, en metod som ofta används i länder som USA, Australien och Canada. Syftet med detta examensarbete är att undersöka hur denna metod kan användas, men också hur allmänheten på bästa sätt kan bli involverade i beslut som berör dem själva. För att komplettera teorin som använts i arbetet har en case study gjorts inom Järvalyftet, ett av dagens största ombyggnadsprojekt i Stockholmsområdet. En SKB berör många olika områden och frågor och är därför en komplex process att genomföra. Det är följaktligen viktigt att skapa en grupp med varierande yrkesdiscipliner för att hantera arbetet och möta de olika problemen på bästa möjliga sätt. Arbetet visar på att allmänhetens deltagande är av stor betydelse för att skapa förankring bland berörda parter då ett projekt planeras, för att på så sätt minska både projektets tidsram och kostnad. Vidare visar även arbetet att involvering av allmänheten i ett tidigt skede av projektet underlättar för de berörda att hantera de förändringar och avvägningar som projektet medför.