Em estudos recentes, a epistasia tem sido detectada no controle genético de caracteres quantitativos em diversas espécies. Dado o grande número de locos controlando um único caráter, é evidente que ocorram interações inter-alélicas, além de pleiotropia, que resulta do controle de mais de um caráter por um mesmo loco. Também tem sido reportada a presença de epistasia pleiotrópica em animais, que basicamente resulta do efeito da epistasia sobre locos pleiotrópicos ou sobre múltiplos caracteres, afetando a correlação genética entre esses. Desse modo, o objetivo desta pesquisa foi a análise genética de diversos caracteres de importância econômica e agronômica em milho, incluindo estimativas de componentes de variância genética e presença de efeitos epistáticos em ambientes com e sem estresse hídrico; e estimativas de epistasia pleiotrópica. Para isso foi utilizado o delineamento triple test cross (TTC), obtendo-se 300 progênies de retrocruzamentos que foram avaliadas em oito ambientes nos anos agrícolas de 2008/2009 e 2009/2010, na cidade de Piracicaba, São Paulo, Brasil. Ao longo da condução dos experimentos observou-se a ocorrência de déficit hídrico, de modo que os ambientes foram divididos em dois grupos (sem estresse - SE e com estresse - CE). Avaliou-se os caracteres da planta: dias para os florescimentos masculino (FM) e feminino (FF), intervalo entre florescimentos (IF), altura da planta (AP) e espiga (AE), posição relativa da espiga (PRE), acamamento e quebramento de plantas (ACQ), stay green (SG); produção de grãos (PG) e seus componentes de produção: número de fileiras (NF), número de grãos por fileira (NGF), peso de 300 grãos (P300), comprimento de grãos (CG) e prolificidade (PRO). Foram realizadas análises de variâncias individuais para cada ambiente; análises conjuntas de ambientes; e análises conjuntas de grupos, das quais estimaram-se as variâncias aditiva, de dominância, epistática e suas respectivas interações com ambiente; o grau médio de dominância, coeficientes de herdabilidade em nível de médias de progênies e em nível de parcelas e também os efeitos epistáticos em plantas F2. Também foram feitas análises de covariâncias considerando todos os caracteres combinados dois a dois, tendo sido estimados os coeficientes de correlações. A epistasia foi detectada para a maioria dos caracteres nos dois grupos, exceto ACQ, IF, SG e CG, no grupo SE; e ACQ, CG e PRO, no grupo CE. Porém não foi detectada interação epistasia x ambiente em nenhum dos grupos e a interação epistasia x grupos só foi detectada para IF. Os efeitos epistáticos em plantas F2 para PG variaram de -3,03 t ha-1 a 5,13 t ha-1 no grupo SE e -1,94 t ha-1 a 2,87 t ha-1 no grupo CE, mas não foram detectadas altas magnitudes dos coeficientes de correlações entre esses efeitos e as médias gerais dos retrocruzamentos. Foram detectados coeficientes de correlações epistáticas para 29,67% das combinações, indicando a presença de epistasia pleiotrópica entre caracteres. Observou-se a formação de agrupamentos entre caracteres relacionados. Em vista desses resultados, a epistasia se constituiu num componente importante no controle dos caracteres analisados, sugerindo ainda que a epistasia pleiotrópica possa ser responsável pelas interações complexas no genoma. / In recent studies, epistasis has been considered in genetic control of quantitative traits in several species. Due to a large number of loci controlling a single trait, it is evident that inter allele interactions occur in addition to pleiotropy, which results in the control of more than one trait by the same locus. Besides, the presence of pleiotropy, epistasis has been reported in animals, which basically result from the effect of epistasis on pleiotropic loci or on multiple traits, affecting the genetic correlation between them. Thus, the objective of this research was to do genetic analysis of several traits of economic and agronomic importance in maize, including estimates of genetic variance components and the presence of epistatic effects in environments with and without water stress; and estimates of pleiotropic epistasis. For this, the triple test cross (TTC) design was used to obtain 300 backcrosses progenies, which were evaluated in eight environments in the 2008/2009 and 2009/2010 agricultural seasons, in Piracicaba, Sao Paulo State, Brazil. During the conduction of the experiments, the occurrence of water deficit was observed, so that the environments were divided into two groups (without stress - WS and with stress - SS). The traits evaluated were: days to anthesis (DA), days to silking (DS), anthesis-silking interval (ASI), plant height (PH), ear height (EH), ear placement (EP), root and stalk lodging (PL) and stay green (SG), grain yield (GY), kernel rows (KR), kernels per row (KPR), 300-grain weight (300W), kernel depth (KD) and prolificacy (PRO). Individual analysis of variances were performed for each environment; joint analysis of environments; and joint analysis of groups, from which additive, dominance and epistatic variances and their respective interactions with the environment were estimated; besides average degree of dominance, heritability coefficients at level of half-sib progenies and at plots level; also epistatic effects in F2 plants were estimated. Covariance analyses were also performed considering all pairs of traits, two by two, and the correlation coefficients were estimated. Epistasis was detected for most traits in both groups except to PL, ASI, SG and KD, in WS group; and PL, KD, and PRO, in SS group. However, no epistasis x environment interaction was detected in any group and epistasis x group interaction was detected only to ASI. Epistatic effects on F2 plants were detected to GY, oscillating from -3.03 t/ha to 5.13 t/ha in WS group and from -1.94 t/ha to 2.87 t/ha in SS group. However, high magnitudes of correlation coefficients between these F2 epistatic effects and averages of backcrosses were not detected. Epistatic correlation coefficients were detected for 29.67% of pairs of traits, indicating the presence of pleiotropic epistasis. The formation of clusters was observed between related traits. In view of these results, epistasis was considered an important component in the control of traits analyzed, furthermore suggesting that pleiotropic epistasis may be responsible for complex interactions in the genome.

O termo sustentabilidade corporativa refere-se à capacidade de uma organização de sobreviver no longo prazo, mantendo-se (minimamente) lucrativa para que possa exercer suas atividades com cada vez menos impactos negativos ambientais e mais benefícios sociais. Considerando a lógica de que a empresa é aquilo que ela é capaz de mensurar, organizações sustentáveis demandam sistemas gerenciais de mensuração de desempenho que estejam alinhadas ao desenvolvimento sustentável. Assim, o presente estudo se propõe a discutir a seguinte pergunta de pesquisa: Como é inserida a sustentabilidade nos sistemas de mensuração de desempenho corporativos? Para isso, são propostos dois objetivos de pesquisa: (i) levantar os sistemas de mensuração de desempenho de sustentabilidade e explorar seus principais desafios; e (ii) explorar a importância relativa dada pelas empresas em relação aos indicadores de sustentabilidade. Para isso, a pesquisa conta com uma revisão sistemática da literatura e estudos de casos multissetoriais (um piloto e quatro exploratórios). A pesquisa traz evidências de que a temática de indicadores de sustentabilidade é ainda incipiente e pouco estruturada, com potencial de melhorar o aproveitamento da literatura já consolidada de sistemas de mensuração de desempenho. O estudo bibliométrico conta com (i) estatística descritiva, (ii) análise de redes de relacionamento (co-citação e palavras-chave) e (iii) análise de conteúdo a partir de uma amostra de artigos extraídos da base de dados ISI Web of Knowledge (Web of Science). Verifica-se que a literatura de indicadores de sustentabilidade aborda temáticas diversas, tais como vantagem competitiva, gestão de stakeholders e avaliação do ciclo de vida. Já os estudos de casos baseados em entrevistas semi-estruturadas permitiram o levantamento dos seguintes sistemas de mensuração de desempenho com incorporação de indicadores de sustentabilidade: sistema de avaliação de desempenho das áreas, sistema de avaliação de desempenho individual, indicadores para elaboração de relatórios internos e externos e sistema de avaliação inicial de projetos. Além disso, foram identificados fatores que interferem na prioridade dos indicadores de sustentabilidade: estratégia corporativa, pré-requisito; maturidade da questão e urgência. Dentre os desafios apontados pelas empresas, encontram-se a definição de indicadores para avaliar os benefícios sociais decorrentes das atividades da organização, a quantificação monetária de retorno de iniciativas ambientais e sociais e o engajamento dos colaboradores na sustentabilidade corporativa, independente da natureza das suas atividades. A pesquisa mostra que há benefícios na incorporação da sustentabilidade no sistema de mensuração de desempenho corporativo e que isso ainda tem potencial para ser abordado de forma mais sistemática, sem depender exclusivamente da iniciativa de determinados líderes. O papel desses atores para implantação de práticas sustentáveis na organização é fundamental e necessário, mas não suficiente, já que a sustentabilidade corporativa depende do engajamento de diversos stakeholders (internos e externos à organização), que podem ser influenciados pela cultura e pelos processos de negócios alinhados à lógica do desenvolvimento sustentável. / The term corporate sustainability refers to the ability of an organization to survive in the long term, keeping itself (minimally) profitable in order to conduct their activities with less negative environmental impacts and more social benefits. Whereas the logic that the company is what it is capable of measuring, sustainable organizations require performance management systems that are aligned to sustainable development. Thus, this study aims to discuss the following research question: \"How sustainability is embedded in corporate performance measurement systems?\" For this, it proposes two research objectives: (i) identify the sustainability performance measurement systems and explore their major challenges, and (ii) explore the relative importance given by companies in relation to sustainability indicators. So, the research has a systematic literature review and multisectoral exploratory case studies (one pilot and four exploratory). The research provides evidence that the theme of sustainability indicators is still incipient and unstructured, with the potential to improve the use of literature already consolidated on performance measurement systems. The bibliometric study is based on (i) descriptive statistics, (ii) analysis of extracted networks of relationships (co-citation and keywords) and (iii) content analysis of a given sample of articles extracted from ISI Web of Knowledge (Web of Science). It is found that the literature of sustainability indicators covers different topics such as competitive advantage, stakeholder management and life cycle assessment (LCA). The cases studies based on semi-structured interviews allowed the identification of the following performance measurement systems that incorporate sustainability indicators: performance evaluation of the areas; individual performance evaluation system; indicators for internal and external reports; and initial project evaluation system. In addition, factors influencing the priority of sustainability indicators have been identified: maturity of the issue, requirement, corporate strategy and urgency. Among the challenges faced by companies, there are the definition of indicators to assess the social benefits of the organization activities, the quantification of the monetary return of environmental and social initiatives and employee engagement in corporate sustainability, independently of the nature of their activities. Research shows that there are benefits in incorporating sustainability in corporate performance measurement system and it still has the potential to be addressed more systematically, without relying solely on the initiative of certain leaders. The role of these actors for implementing sustainable practices in the organization is essential and necessary, but not sufficient, since the corporate sustainability depends on the engagement of various stakeholders (internal and external to the organization), which may be influenced by the culture and the business processes aligned to the logic of sustainable development.

La protéine E4F1 découverte comme cible cellulaire de l'oncoprotéine adénovirale E1A est une protéine ubiquitaire agissant comme facteur de transcription et comme E3-ligase atypique. La protéine E4F1 interagit également directement avec plusieurs gènes suppresseurs de tumeurs et des oncoprotéines, suggérant son implication dans la tumorigénèse. Des travaux antérieurs du laboratoire, sur les fonctions cellulaires d’E4F1 dans les cellules cancéreuses ont montré que sa déplétion entraîne une mort cellulaire massive dans les Mefs transformés déficients en p53. De plus, E4F1 contrôle directement l'expression de 38 gènes, notamment impliqués dans le métabolisme cellulaire et les checkpoints du cycle cellulaire/Réponse aux dommages de l'ADN (DDR), tel que Chek1 qui code un composant majeur du checkpoint ATR/ATM. Conformément à ce rôle d’E4F1 dans la survie des cellules cancéreuses chez la souris, des patientes atteintes d'un cancer du sein triple négatif (TNBC) exprimant fortement E4F1 présentent une survie sans rechute (RFS) plus faible.Nous avons donc décidé d’étudier pour la première fois le programme transcriptionnel d’E4F1 dans les cellules humaines et d’explorer son rôle dans la survie des cellules de TNBC, avec une attention particulière pour son rôle dans la réponse aux agents de chimiothérapie.Les transcriptomes (RNAseq) de cellules SUM159 de TNBC montrent, lors de la déplétion d’E4F1, une diminution de l’expression de 147 des 276 gènes associés à la DDR. La combinaison de RNAseq et de ChIPseq révèle qu’E4F1 régule directement 57 gènes dans les cellules de TNBC humaines. Parmi ces gènes, E4F1 lui-même, CHEK1, mais aussi TTI2 et PPP5C codant pour des régulateurs post-transcriptionnels de l'axe ATM/ATR-CHK1, et définissant ainsi un "régulon" ATM/ATR-CHK1, encore inconnu et dépendant d’E4F1. TTI2 forme avec TELO2 et TTI1, le complexe TTT nécessaire au repliement correct et à la stabilité des protéines de la famille PIKK, telles qu’ATR et ATM. La phosphatase PPP5C est impliquée dans l'activation de la signalisation ATR-CHK1. Fait important, nous montrons qu’E4F1 se fixe sur et régule probablement ces trois gènes in vivo dans des tumeurs TNBC dérivées de patientes (PDTX). Dans la lignée SUM159 et les PDTX, le recrutement d’E4F1 sur ces gènes est augmenté lors du traitement avec la Gemcitabine, un agent de chimiothérapie bloquant la réplication de l’ADN. Étonnamment, nous avons révélé qu’E4F1 contrôle aussi indirectement l'expression de TELO2, un second membre du complexe TTT. Par conséquent, dans les cellules TNBC déplétées en E4F1, les taux de protéines des CHK1, TTI2, TELO2 mais aussi des kinases ATM/ATR, sont fortement diminués, entraînant une déficience de la DDR. Ainsi, les cellules SUM159 déplétées en E4F1 ne parviennent pas à s'arrêter en phase S lors du traitement à la Gemcitabine et sont hautement sensibilisées à cet agent de chimiothérapie, ainsi qu'à d'autres agents endommageant l'ADN comme le Cisplatine. Dans leur ensemble, mes travaux de thèse révèlent que la voie de signalisation ATM/ATR-CHK1, et la réponse au stress / dommages de l'ADN sont étroitement contrôlées aux niveaux transcriptionnel et post-transcriptionnel par E4F1. E4F1 apparait donc comme un acteur central dans la survie cellulaire des cellules TNBC, en particulier lorsqu'elles sont exposées à des agents endommageant l'ADN ou à des agents de chimiothérapie. Ainsi E4F1 pourrait représenter un marqueur pronostique de réponse à la chimiothérapie et une cible thérapeutique potentielle. / The E4F1 protein discovered as the cellular target of the adenoviral oncoprotein E1A is a ubiquitous protein acting both as a transcription factor and as an atypical E3-ligase. E4F1 protein also interacts directly with several cellular tumor suppressors and oncoproteins, suggesting its involvement in tumorigenesis. Previous laboratory work on the cellular functions of E4F1 in cancer cells has shown that its depletion leads to massive cell death in transformed Mefs deficient in p53. In addition, E4F1 directly controls the expression of 38 genes, including genes involved in cell metabolism and cell cycle checkpoints/DNA Damage Response (DDR), such as Chek1 that encodes a major component of the ATR/ATM checkpoint. Consistent with this role of E4F1 in cancer cell survival in mice, patients with triple-negative breast cancer (TNBC) with high E4F1 expression exhibit a poorer relapse free survival (RFS).We therefore aimed to study for the first time the transcriptional program of E4F1 in human cells and explore its role in the survival of TNBC cells, with particular focus on its role in the response to chemotherapy agents.Transcriptomes (RNAseq) of SUM159 TNBC cells show, when E4F1 is depleted, a decrease in expression of 147 out of 276 DDR-associated genes. The combination of RNAseq and ChIPseq shows that E4F1 directly regulates 57 genes in human TNBC cells. Among these genes, E4F1 itself, CHEK1, but also TTI2 and PPP5C coding for post-transcriptional regulators of the ATM/ATR-CHK1 axis, and thus defining an ATM/ATR-CHK1 "regulon", undescribed and E4F1-dependent. TTI2 composes with TELO2 and TTI1, the TTT complex required for the correct folding and stability of PIKK family proteins, such as ATR and ATM. PPP5C phosphatase is involved in the activation of ATR-CHK1 signaling. Importantly, we show that E4F1 binds to and probably regulates these three genes in vivo in Patient Derived TNBC Xenografts (PDTX). In both SUM159 cells and PDTX, the recruitment of E4F1 on these genes is increased upon Gemcitabine treatment, a chemotherapy agent that impairs DNA replication. Surprisingly, we found that E4F1 also indirectly controls the expression of TELO2, a second member of the TTT complex. Consequently, in TNBC cells depleted of E4F1, the protein levels of CHK1, TTI2, TELO2 but also ATM/ATR kinases, are significantly decreased, leading to DDR deficiency. Thus, SUM159 cells depleted of E4F1 fail to stop in phase S during Gemcitabine treatment and are highly sensitized to this chemotherapy agent, as well as other DNA damaging agents such as Cisplatin. Altogether, my thesis results demonstrate that the ATM/ATR-CHK1 signaling pathway, and the response to stress / DNA damage are tightly controlled at the transcription and post-transcription levels by E4F1. E4F1 therefore appears to be a central actor in the cellular survival of TNBC cells, particularly when exposed to DNA-damaging agents or chemotherapy agents. Thus, E4F1 could represent a prognostic marker for chemotherapy response and a potential therapeutic target.

En cryptographie classique, un algorithme de chiffrement est considéré comme une boîte noire, et un attaquant n'a accès qu'aux textes clairs et chiffrés. Mais un circuit cryptographique émet aussi des informations sensibles lors d'une opération cryptographique, comme sa consommation de courant ou ses émissions électro-magnétiques. Par conséquent, différentes techniques, appelées attaques par canaux auxiliaires, permettent d'exploiter ces fuites d'informations physiques pour casser des algorithmes cryptographiques avec une complexité très faible en comparaison avec les méthodes de la cryptanalyse classique. Dans ce travail, les attaques par canaux auxiliaires basées sur la consommation de courant ou les émissions électro-magnétiques sont d'abord étudiées d'un point de vue algorithmique, et différentes améliorations sont proposées. Ensuite, une attention particulière est consacrée à l'exploitation du canal auxiliaire électro-magnétique, et un flot de simulation des radiations magnétiques des circuits intégrés est proposé et validé sur deux microcontrôleurs. Finalement, certaines contremesures permettant de protéger les algorithmes de chiffrement contre ces menaces, basées sur des styles de logique équilibrées, sont présentées et évaluées. / In cryptography, a cipher is considered as a black-box, and an attacker has only access to plaintexts and ciphertexts. But a real world cryptographic device leaks additionnal sensitive informations during a cryptographic operation, such as power consumption or electro-magnetic radiations. As a result, several techniques, called Side-Channel Attacks, allow exploiting these physical leakages to break ciphers with a very low complexity in comparison with methods of classical cryptanalysis. In this work, power and electro-magnetic Side-Channel Attacks are firstly studied from an algorithmic point-of-view, and some improvements are proposed. Then, a particular attention is given on the exploitation of the electro-magnetic side-channel, and a simulation flow predicting magnetic radiations of ICs is proposed and validated on two microcontrollers. Finally, some countermeasures allowing to protect ciphers against these threats, based on balanced logic styles, are presented and evaluated.

Les modules photovoltaïques à concentration (CPV) ont tendance à se miniaturiser. D’une part, la distance focale plus courte des optiques de concentration permet de réduire le besoin en matériaux pour l’assemblage du module ; et d’autre part, le rendement des modules est sensiblement meilleurs que ceux des modules CPV de taille normale. L’étude de chaque élément de la chaine de pertes dans la littérature des micro-concentrateurs a permis de confirmer cette tendance. Cette thèse aborde les problématiques de coût et de rendement à travers la conception optique d’un concentrateur à deux étages de lentilles, sa fabrication puis une étude approfondie de ses performances.La méthode de conception, développée à partir de lois d’optique géométrique et non-imageante, définit le profil des lentilles à λ=589nm en premiers lieux. Ensuite, une simulation par tracé de rayons permet d’optimiser ces lentilles pour l’ensemble du spectre solaire puis d’étudier l’impact de leur désalignement lors de la mise en module. Les limites des déplacements des éléments du module ainsi déterminées conditionnent la précision de sa fabrication. Dans notre cas, l’alignement est réalisé automatiquement par un jeu de repères mécaniques lors du moulage simultané des optiques primaires (POE) et des optiques secondaires (SOE). Contrairement aux procédés habituels, ce procédé de moulage innovant permet d’assembler un module en seulement trois étapes au lieu de cinq.Pour caractériser les micro-concentrateurs réalisés, une méthode de mesure du rapport module à cellule (CTM) est développée. Pour cela, le rendement des cellules est mesuré en simulateur solaire avant et après leur mise en module. Les cellules multi-jonctions mises en œuvre étant sensibles aux variations spectrales et spatiales de l’éclairement, la validation préalable de ces mesures est primordiale. En complément du CTM qui quantifie la somme des pertes introduites lors de la mise en module, d’autres mesures sont développées pour comprendre la chaine de perte plus en détails.Le dispositif étudié au cours de cette thèse utilise des cellules triple-jonction de 0,6 x 0,6mm² avec une concentration de 1000X et atteint un rendement de 29%. Le CTM est de 70% et l’analyse de la chaine de perte montre que le procédé inventé n’impacte pas ou peu les performances du module. De plus, la détermination de la chaine de perte montre que les pertes par réflexion et par absorption sont prédominantes, au même titre que les pertes dues à la diffusion des lentilles ainsi que les pertes dues aux non-uniformités d’éclairement sur la cellule. / The actual trend of CPV is the micro-scaling of modules. A bibliographic study shows that shorter focal length of optics implies less material consumption in manufacturing and an enhanced efficiency of the modules. In this thesis, a double stage refractive micro-concentrator is designed, manufactured and characterized. First, the optical design of the concentrator is based on non-imaging technics. Thus, the profile of the lenses is generated for a single wavelength. Then, a ray tracing simulator is used to optimize the lens profile for the overall solar spectrum and study the concentrator element misalignment effect on the performances.Secondly, a three steps self-assembly process is developed instead of the usual five steps one. Both POE and SOE lenses of our device are molded simultaneously and a mechanical guidance system in the mold ensures the alignment of the micro-concentrator elements (POE, SOE and Cell).Finally, the performances measurements of the manufactured modules are managed in solar simulators in which the lightening condition are previously studied and validated. Comparing the bare cells efficiency with the module efficiency, the cell-to-module ratio (CTM) represents the overall losses in the module. Further experiments are managed to quantify each loss of the module. The manufactured and characterized micro-concentrator is a 1000X concentrating ratio with 0.6 x 0.6mm² triple junction cells. It efficiency is 29% with a 70% CTM. Finally, the loss chain study reveals that the three steps self-assembly process is reliable.

O objetivo desta tese foi analisar as representações e as políticas de controle para as mortes violentas na Tríplice Fronteira Brasil-Paraguai-Argentina. A teoria de base foi a da Criminologia Cultural e a abordagem foi comparativa. Os dados foram obtidos a partir de pesquisa documental e de entrevistas realizadas mediante um questionário semi-estruturado. A análise desses dados resultou na conclusão de que as forças culturais dominantes do lado brasileiro representam as letalidades relacionadas aos mercados ilícitos transnacionais. No lado paraguaio verificou-se uma divisão entre os motivadores relacionados ao narcotráfico e aos motivadores não relacionados ao narcotráfico. Por fim, no lado argentino predomina a representação sobre motivadores interpessoais. No Brasil, como consequência dessas representações para a formulação de políticas ocorreu a implementação de políticas de controle com perfis distintos: duas fases são políticas de urbanização e uma de operações policiais. A primeira política foi o Projeto “Beira Rio”, que promoveu a remoção das favelas que estavam na barranca do rio Paraná. Uma das consequências dessa política foi o aumento das taxas de letalidades em Foz do Iguaçu, entre os anos 1993 a 2006. A segunda política adotada no lado brasileiro foi a intensificação das forças de segurança para coibir o “circuito sacoleiro”. O resultado imediato dessa política foi o desencadeamento de uma série de mudanças nas práticas ilícitas, que se difundiram para toda a região. Como consequência, as taxas de letalidades de Foz do Iguaçu caíram a partir do ano de 2006, mas difundiram-se para os municípios vizinhos A terceira política de controle está em desenvolvimento e trata-se do Projeto “Beira Foz”, que ganhou apoio da Itaipu Binacional e dos governos estadual e federal. No lado argentino, a construção da “Avenida Costaneira” com caráter urbanístico não influenciou no comportamento das letalidades em Puerto Iguazú. No lado paraguaio, a reestruturação da Praça San Blas e das “Etapas I, II, III e IV” também não influenciaram no comportamento das taxas das mortes violentas. A política implantada para conter o “circuito sacoleiro” pelo Brasil não foi arquitetada pelas forças culturais do local, mas implementadas pelo governo federal, juntamente com o governo do estado do Paraná, por pressões do governo americano, em um plano maior de seguridade para a Tríplice Fronteira: a “guerra ao terror”, com o propósito de atingir o comércio dos árabes de Ciudad del Este. Essa intervenção revela que a Tríplice Fronteira e suas questões de segurança não foram pensadas somente em nível local, mas também em nível nacional e global. O setor subcultural brasileiro contraria a ideia de que a fronteira e esses mercados transnacionais seriam os causadores das mortes violentas. Esses espaços periféricos, inflados pelos mercados ilícitos, fazem valer os códigos de conduta e os códigos de honra. / The objective of this thesis was to analyze the representations and control policies for violent deaths in the Triple Border Brazil-Paraguay-Argentina. The basic theory was the Cultural Criminology and the approach was comparative. Data were obtained from desk research and interviews conducted by a semi-structured questionnaire. Analysis of these data resulted in the conclusion that the dominant cultural forces of the Brazilian side represent the lethality related to transnational illicit markets. On the Paraguayan side there was a division among the motivators related to drug trafficking and motivators unrelated to drug trafficking. Finally, on the Argentine side dominates the representation of interpersonal motivators. In Brazil, the consequences of these representations for the formulation of control policies were the implementation of control policies with different profiles: two phases are development policies and police operations. The first policy was the “Beira Rio” Project, which promoted the removal of slums that were in the Paraná river gorge. One consequence of this policy was the increase in mortality rates in Foz do Iguaçu, between the years 1993-2006. The second policy adopted on the Brazilian side was the intensification of security forces to curb the “sacoleiro circuit”. The immediate result of this policy was the development of a series of changes in the illicit practices that have spread to the entire region. As a result, the Foz do Iguaçu mortality rates fell from 2006, but spread to neighboring municipalities The third control policy is under development and it is the “Beira Foz” Project, which won support from Itaipu Binacional and the state and federal governments. On the Argentine side, the construction of the “Costanera Avenue” with urban character did not influence the behavior of lethality in Puerto Iguazú. On the Paraguayan side, the restructuring of the San Blas Square and the “Stages I, II, III and IV” did not influence the behavior of rates of violent deaths. The policy implemented to contain the “sacoleiro circuit” in Brazil, was not architected for cultural local forces, but implemented by the federal government, along with the government of the state of Paraná, by the American government pressures in a larger plan of security for Triple Frontier: the “war on terror”, in order to achieve trade of the Arabs of Ciudad del Este. This intervention shows that the Triple Border and its security issues have not been thought only locally, but also nationally and globally. The Brazilian subcultural sector contradicts the idea that the border and these transnational markets would be the cause of violent deaths. These peripheral areas, inflamed by illicit markets, do enforce codes of conduct and codes of honor. / El objetivo de esta tesis es analizar las representaciones y las políticas de control de las muertes violentas en la triple frontera Brasil-Paraguay-Argentina. La teoría básica fue la criminología cultural y el enfoque fue comparado. Los datos se obtuvieron a partir de la investigación documental y entrevistas realizadas por un cuestionario semi-estructurado. El análisis de estos datos dio lugar a la conclusión de que las fuerzas culturales dominantes del lado brasileño representan las letalidades relacionadas con los mercados ilícitos transnacionales. En el lado paraguayo había una división entre los motivadores relacionados con el tráfico de drogas y motivadores no relacionadas con el tráfico de drogas. Por último, en el lado argentino domina la representación de los motivadores interpersonales. En Brasil, como resultado de estas representaciones para la formulación de políticas se puso en práctica políticas de control con diferentes perfiles: dos fases son las políticas de desarrollo y una de operación policial. La primera política fue el Proyecto “Beira Rio”, que promueve la eliminación de los barrios pobres que estaban en la garganta del río Paraná. Una consecuencia de esta política fue el aumento de las tasas de mortalidad en Foz de Iguazú, entre los años 1993-2006. La segunda política adoptada en el lado brasileño fue la intensificación de las fuerzas de seguridad para frenar el “circuito sacoleiro”. El resultado inmediato de esta política fue el desarrollo de una serie de cambios en las prácticas ilícitas que se han extendido a toda la región Como resultado, la tasas de la mortalidad de Foz de Iguazú disminuyeron a partir de 2006, sino que se extienden a los municipios vecinos. La tercera política de control está en desarrollo y que es el Proyecto “Beira Foz”, que obtuvo el apoyo de la Itaipú Binacional y los gobiernos estatales y federales. En el lado argentino, la construcción de la “Avenida Costanera” con carácter urbano no influyó en el comportamiento de letalidad en Puerto Iguazú. En el lado paraguayo, la reestructuración de la plaza de San Blas y las “Etapas I, II, III y IV” no influyó en el comportamiento de las tasas de muertes violentas. La política implementada para contener el “circuito sacoleiro” por el Brasil no fue arquitectura para las fuerzas locales culturales, pero aplicadas por el gobierno federal, junto con el gobierno del estado de Paraná, por las presiones del gobierno estadounidense en un plan más amplio de seguridad para Triple Frontera: la “guerra contra el terror”, con el fin de lograr un comercio de los árabes de Ciudad del Este. Esta intervención se comprobara que la Triple Frontera y sus problemas de seguridad no se han pensado sólo a nivel local, sino también a nivel nacional como a nivel mundial. El sector subcultural brasileña contradice la idea de que la frontera y estos mercados transnacionales serían la causa de las muertes violentas. Estas áreas periféricas, inflamados por los mercados ilícitos, hacer cumplir los códigos de conducta y códigos de honor.

Cette thèse vise principalement à décorer des phtalocyanines avec des groupes de reconnaissance supramoléculaires pour induire leur auto-assemblage pour la première fois avec ces chromophores robustes imitant les bactériochlorophylles chlorosomales naturelles. D’autre part, cette thèse est également dédiée à la méthodologie de synthèse des complexes à trois étages avec des lanthanides complexant des porphyrines et phtalocyanines encombrantes.La première partie présente quelques concepts de base et des exemples segéstifs dans la biomimétique et l’auto-assemblage moléculaire. Les auto-assemblages biomimétiques des bactériochlorophylle c, d, e ont été examinés suivie par la synthèse, la séparation des régioisomères des phtalocyanines et des cellules solaires construites avec des phtalocyanines. La deuxième partie présente des travaux originaux sur une série d'antennes pour la coolléction de la lumière, comme les acylphthalocyanines qui font d'auto-assemblage avec des groupes carbonyle comme motifs de reconnaissance, un atome de zinc central et diverses chaînes alkyle de solubilisation. Ces nouveaux composés pourraient s’auto-assembler de la même manière que les bactériochlorophylles naturelles. La troisième partie de cette thèse se concentre sur les propriétés électrochimiques et magnétiques de lanthanides-porphyrine-phtalocyanine complexes sandwich ‘’triple deckers’’ volumineux, synthétisés par une nouvelle méthode sous irradiation avec des micro-ondes. Le site initial de l'oxydation ou de réduction de ce type de molécules à trois étages a d'abord été attribué par la combinaison de la spectroélectrochimie de couche mince. / This thesis mainly aims to decorate phthalocyanines with supramolecular recognition groups for inducing their self-assembly for the first time with these robust chromophores mimicking the natural chlorosomal bacteriochlorophylls. Meanwhile, this thesis is also dedicated to the synthetic methodology of bulky lanthanide porphyrin phthalocyanine triple-decker complexes. The first part provides some basic concepts and some delicate examples in biomimetics and molecular self-assembly, then biomimetic bacteriochlorophyll c, d, e self-assembles were simply reviewed, followed by the introduction on the synthesis, regioisomer separation of phthalocyanines and phthalocyanine-sensitized solar cells. The second part presents a series of light-harvesting antennas, namely self-assembling acyphthalocyanines, with carbonyl groups as recognition motifs, a central zinc atom and various solubilizing alkyl chains, which could self-assemble in the same way as the natural bacteriochlorophylls. These assemblies were characterized by UV-Vis, Variable-temperature UV-Vis and 1H-NMR spectra. The third part of this thesis focuses on the electrochemical and magnetic properties of bulky lanthanide porphyrin phthalocyanine triple-decker complexes synthesized by microwave-mediated, therein, the initial site of oxidation/reduction on this type of triple-decker molecules was firstly assigned by combining the thin-layer spectroelectrochemistry and the assignments of the electronic absorption spectra. Furthermore, the different single-molecule magnet behaviors of the corresponding Tb and Dy triple-decker complexes were also studied.

Ce mémoire de thèse se concentre sur le développement de réactions multicatalysées impliquant une activation iminium et un transfert d’hydrogène réversible rédox-neutre pour la synthèse de briques moléculaires complexes énantioenrichies à partir de composés 1,3-dicarbonylés et d’alcools allyliques.Une cascade réactionnelle combinant un complexe de fer et une pyrrolidine chirale a été développée pour la préparation d’alcools g-fonctionnalisés énantioenrichis par une approche impliquant économie d’étapes et d’atomes. L’efficacité de cette méthode impliquant une catalyse duale ainsi qu’une étape de rétro-Claisen a été démontré dans la synthèse de fragments clés de produits naturels. Cette méthodologie a ensuite été complétée par une étude mécanistique expérimentale aboutissant à une meilleure compréhension du mécanisme de cette transformation et conduisant également au développement d’une catalyse triple impliquant deux complexes métalliques et un organocatalyseur. Par la suite, une nouvelle approche pour la synthèse de lactones énantioenrichies de taille de cycles moyens a été mise au point. Cette stratégie de synthèse est basée sur une addition-1,4- organocatalysée énantiosélective de Michael, suivie d’une réduction chimiosélective qui engendre une fragmentation de Claisen.Enfin, grâce aux méthodologies développées au cours de cette thèse, la synthèse totale d’un produit naturel, la floribundane B, a été étudiée. / This manuscript is focus on the development of multicatalyzed reactions involving iminium activation and reversible neutral hydrogen transfer reaction for the synthesis of complexe enantioenriched building blocks from allyl alcohols and 1,3-dicarbonyls.An unprecedented cascade catalysis combining an iron catalyst and a pyrrolidine-base catalyst is developed for the preparation of g-fonctionalized enantioenriched alcohols in a formal redox-, atom- and step-economical approach. The efficiency of this method involving a dual catalysis and a retro-Claisen xas further demonstrated in the short synthesis of several key fragments of biologically active natural products or odorant molecule. This methodolgy was then incremented by a experimental mechanistic study allowing a better understanding of the mechanism of this transformation and leading to a new catalytic systeminvolving three different catalysts (iron complex, copper and organocatalyst). Then, we focused on the development of a new synthetic approach to enantioenriched medium-sized lactones. This methodology is based on a 1,4-Michael addition of cycloalkane-1,3-diones to a,b-insaturated aldehydes. Then, a key chemoselective reductively triggered Claisen fragmentation occurred to generate desired lactones in a rapid manner.Finally, thanks to our methodology developed during this thesis, the total synthesis of floribundane B was studied.

[pt] A gestão de riscos inerente à cadeia de suprimentos de uma empresa tornou-se um direcionador decisivo para o crescimento da mesma, sendo assim um diferencial competitivo. A literatura sobre gerenciamento de risco é diversa; no entanto, pouco a respeito dos riscos sociais em que a cadeia de suprimentos de uma empresa pode estar envolvida, foi estudado. O presente estudo fundamenta-se, portanto, inicialmente, em uma revisão sistemática da literatura para identificação de riscos sociais presentes nas cadeias de suprimentos de uma empresa, nas consequências que estes podem gerar para a empresa focal e, nos stakeholders envolvidos neste processo. A partir da amostra de 43 documentos resultantes da revisão sistemática da literatura, dos 24 riscos sociais encontrados e das 13 consequências que estes riscos podem gerar para a empresa, é apresentado um fluxograma para auxiliar acadêmicos e organizações na gestão de riscos sociais. Posteriormente, é proposto um estudo de caso com uma empresa brasileira de cosméticos com o intuito de verificar a relação das variáveis identificadas na literatura com a realidade organizacional. Constatou-se que 11 dos 24 riscos sociais advindos da etapa de revisão não são observados pela empresa estudada e, dentre as consequências, as mais citadas relacionam-se a reputação da empresa, risco de paradas operacionais e reinvindicações individuais ou de ação coletiva. A partir do estudo de caso, foi possível complementar os estudos acadêmicos existentes e sugerir um modelo capaz de ser utilizado como base em organizações, com relação a riscos sociais em suas cadeias de suprimentos. / [en] The risk management inherent in the supply chain of a company has become a decisive driver for its growth, thus being a competitive advantage. The literature on risk management is diverse; however, little about the social risks in which the supply chain of a company may be involved has been studied. The present study is based initially on a systematic literature review to identify social risks present in the supply chains of a company, the consequences that these can generate for the focal company and the stakeholders involved in this process. From the sample of 43 documents resulting from the systematic literature review, the 24 social risks found and the 13 consequences that these risks can generate for the company, a framework is presented to assist academics and organizations in managing social risks. Subsequently, a case study with a Brazilian Cosmetics company is proposed with the purpose of verifying the relationship of the variables identified in the literature with the organizational reality. It was verified that 11 of the 24 social risks arising from the review stage are not observed by the company studied and, among the consequences, the most cited ones are related to the reputation of the company, risk of operational stops and individual claims or collective action. From the case study, it was possible to complement the existing academic studies and to suggest a model capable of being used as a basis in organizations with respect to social risks in their supply chains.

Bakgrund och Problemdiskussion: Eftersom att medvetenheten hos intressenter har ökat, har det konstaterats att den klassiska finansiella informationen är otillräcklig. Av samma skäl har fler och fler riktlinjer, ramar för förberedelse samt publicering av icke finansiell information tillkommit de senaste åren. Den icke finansiella informationen är tillgänglig för att öka företagens ansvar och öppenhet mot sina intressenter. Syfte och frågeställning: Syftet med studien har varit att undersöka hur hållbarhetsrapporter i nio företag i Sverige skiljer sig åt i utformning och innehåll. Vidare avsåg vi att identifiera orsaker till skillnader och likheter utifrån standardiserade ramverk, intressentteori samt lagkrav. De hållbarhetsrapporter som har studerats har publicerats av företag som är verksamma inom byggbranschen, finansbranschen samt revisionsbranschen. Teoretisk referensram: Analysen av denna studie bygger på den teoretiska referensram som omfattats av hållbarhetens utformning och fullständighet, lagkrav gällande hållbarhets-redovisning, Triple Bottom Line, Global Reporting Initiative samt intressentteorin. Metod: För att svara på studiens frågeställningar valde vi att analysera nio hållbarhetsrapporter med hjälp av en kvalitativ innehållsanalys. Den kvalitativa innehållsanalysen användes eftersom vi hade avsikten att på ett djupare plan undersöka skillnader och likheter i rapporternas utformning och innehåll. Vidare ville vi få en djupare kunskap kring orsakerna till rapporternas likheter och skillnader. Empiri och slutsats: Studiens resultat visade att det exiterar både likheter och skillnader i hållbarhetsrapporterna i förhållande till miljömässiga, sociala samt ekonomiska aspekter. Skillnaderna och likheterna förklaras med hjälp av intressentteorin, Global Reporting Initiatives, lagkravet och branschtillhörigheten. Företagen har en stor valfrihet gällande utformning av hållbarhetsrapporten, hållbarhetsrapportens innehåll samt val av ramverk, detta leder till stor variation av hållbarhetsrapportens innehåll vilket resulterar i att jämförbarheten blir komplex. / Background and problem discussion: It has been shown that the classical financial information is insufficient due to the increased awareness amongst stakeholders. For the same reason, in recent years, more and more frameworks and guidelines has been placed for the preparation of non-financial information to increase corporate responsibility and openness towards stakeholders. Purpose and question: The purpose of this study was to analyze sustainability reports of nine different companies in Sweden and how the reports differ in structure and content. Furthermore, we intended to identify the differences and similarities by comparing them based on standardized frameworks, stakeholder theory and legal requirements. The companies that has been reviewed are active within the construction industry, finance industry and the auditing industry. Theoretical reference frame: The analysis of the study is based on the theoretical reference framework that covers the structure and completeness, sustainability report`s legal requirements, Triple Bottom Line, voluntary frameworks and guidelines as well as stakeholder theory. Method: In order to answer the research questions, we have chosen to analyze nine sustainability reports using a qualitative content-analysis. The reason why this study is done with a qualitative content-analysis is to identify the underlying causes for the differences and similarities between the sustainability reports. Empirical and conclusion: The research concluded that there are both differences and similarities between the different sustainability reports in relation to the environment, social and economical aspects. The differences are explained through the stakeholder theory and their industrial affiliations. The similarities exist due to the fact that GRI has been a commonly used framework amongst the companies studied.