La survie des Primates Non Humains (PNHs) est menacée par les activités humaines et les maladies infectieuses. Pour contribuer à leur conservation au Gabon, plusieurs structures dont les sanctuaires et centres de primatologie ont été mises en place. Cependant, si la gestion des risques sanitaires n’est pas prise en compte et les conditions d’accompagnement réglementées, ces structures qui visent la sauvegarde des PNHs pourraient constituer de véritables carrefours d’échanges de parasites entre espèces de PNH, Homme et/ou microfaune. Ainsi, pour mieux comprendre la nature et l’ampleur du problème, notre travail de thèse avait pour but d’évaluer les risques sanitaires et zoonotiques chez des groupes d’hôtes de deux (2) sanctuaires et d’un (1) centre de primatologie au Sud-est du Gabon. En combinant les études épidémiologiques sur le terrain à la fois chez l’Homme et l’animal, le séquençage, les analyses phylogénétiques ainsi que la modélisation statistique, nos travaux se sont attelés à comprendre (i) la circulation d’agents infectieux entre espèces et (ii) les stratégies parasitaires dans ces nouveaux contextes de communautés créés par les activités humaines. Nous nous sommes intéressés à trois (3) modèles parasitaires, à savoir ; un (1) procaryote (Staphylococcus aureus) et deux (2) eucaryotes dont un agent pathogène à transmission vectorielle (Plasmodium spp) et un groupe viral à transmission directe ou indirecte (paramyxovirus). Nos résultats révèlent une grande diversité plasmodiale circulant chez les PNHs (9 espèces) et montrent que la spécificité d’hôtes observée jusqu’à présent en milieu naturel est rompue. Si aucun plasmodium simien n’a été trouvé chez l’Homme, le spectre d’hôtes de P. falciparum s’agrandit avec sa mise en évidence pour la première fois chez le Mandrill (Mandrillus sphinx). Nos résultats révèlent également une large diversité génétique de Stahylococcus aureus composée de souches généralistes et spécialistes, la circulation de souches SARM (S. aureus résistant à la méticilline) principalement via les souches généralistes, entre groupes d’hôtes traités et non traités aux antibiotiques et décrivent quinze (15) nouvelles souches. Pour les paramyxovirus, aucune infection n’a été identifiée mais la question du patron de circulation épidémique ou endémique est posée. En conclusion, cette étude montre que dans ces structures (i) les conditions écologiques de franchissement inter-espèces des parasites sont réunies et (ii) que ces dernières permettent le développement d’infections encore jamais observées en milieu naturel. Ces conditions de promiscuité entre espèces favorisent la sélection d’espèces parasitaires à large spectre d’hôtes (i.e., généralistes) mais aussi l’occurrence de souches bactériennes résistantes à la méticilline qui se propagent via la communautarisation des parasites, notamment dans la microfaune interagissant avec les PNHs traités aux antibiotiques ou à partir de l’Homme / The survival of Non-human Primates (NHPs) is threatened by human activities and infectious diseases. To participate in their conservation in Gabon, several facilities among which sanctuaries and the Centre De Primatologie (CDP) of the Centre International de Recherches Médicales de Franceville (CIRMF) have been created. However, if the management of health risks is not taken into account and the supportive conditions are not regulated, these facilities which aim to preserve NHPs could become real crossroads for the transmission of parasites between NHP species, humans and/or microfauna. Therefore, to better understand the nature and the extent of the problem, our thesis work aimed to evaluate the health and zoonotic risks in groups of hosts from two (2) sanctuaries and one (1) primatology center in the south-east of Gabon. By combining epidemiological studies on the field both in humans and animals, sequencing and phylogenetic analyses as well as statistical modelling, our work aimed to understand (i) the circulation of infectious agents between species and (ii) the parasitic strategies in the new context of these communities created by human activities. We focused on three (3) parasitic models, namely: one (1) prokaryote (Staphylococcus aureus) and two (2) eukaryotes among which one pathogenic agent with vectorial transmission (Plasmodium spp) and a viral group with direct or indirect transmission (paramyxovirus). Our results highlight a great plasmodial diversity circulating in NHPs (9 species) and show that the specificity of hosts observed up until now in their natural habitat is broken. No simian plasmodium was found in humans, however the specter of hosts of P. falciparum grows with the new addition of mandrills (Mandrillus sphinx). Our results also reveal a large genetic diversity of Staphylococcus aureus composed of general and specialized strains, the circulation of SARM strains (S. aureus resistant to methicillin) mainly via the general strains, between groups of treated and non-treated hosts to antibiotics. Fifteen (15) new strains are described. Regarding paramyxoviruses, no infection was identified but we raise the question of epidemic or endemic circulation models. To conclude, this study shows that in these facilities (i) the ecological conditions required for inter-species crossing of parasites are gathered and (ii) these conditions allow the development of infections previously never observed in the natural environment. These conditions of promiscuity between species favor the selection of parasitic species with a large specter of hosts (i.e., generalists) but also the occurrence of bacterial strains resistant to methicillin which spread via the communitarisation of parasites, especially in microfauna interacting with NHPs treated with antibiotics or humans

Cette thèse traite de portefeuilles d’assurance avec risques dépendants en théorie du risque.<p>Le premier chapitre traite les modèles avec risques équicorrelés. Nous proposons une structure mathématique qui amène à une fonction génératrice de probabilités particulière (fgp) proposé par Tallis. Cette fgp implique des variables équicorrelées. Puis, nous étudions l’effet de ce type de dépendance sur des quantités d’intérêt dans la littérature actuarielle telle que la fonction de répartition de la somme des montants des sinistres, les primes stop-loss et les probabilités de ruine sur horizon fini. Nous utilisons la structure proposée pour corriger des erreurs dans la littérature dues au fait que plusieurs auteurs agissaient comme si la somme des variables aléatoires équicorrélés aient nécessairement la fgp proposée par Tallis. <p><p>Dans le second chapitre, nous proposons un modèle qui combine les modèles avec chocs et les modèles avec mélanges communs en introduisant une variable qui contrôle le niveau du choc. Dans le cadre de ce nouveau modèle, nous considérons deux applications où nous généralisons le modèle de Bernoulli avec choc et le modèle de Poisson avec choc. Nous étudions, dans les deux applications, l’effet de la dépendance sur la fonction de répartition des montants des sinistres, les primes stop-loss et les probabilités de ruine sur horizon fini et infini. Pour la deuxième application, nous proposons une construction basée sur les copules qui permet de contrôler le niveau de dépendance avec le niveau du choc.<p><p>Dans le troisième chapitre, nous proposons, une généralisation du modèle classique de Poisson où les montants des sinistres et les intersinistres sont supposés dépendants. Nous calculons la transformée de Laplace des probabilités de survie. Dans le cas particulier où les montants des sinistres ont une distribution exponentielle nous obtenons des formules explicites pour les probabilités de survie. <p><p>Dans le quatrième chapitre nous généralisons le modèle classique de Poisson en introduisant de la dépendance entre les intersinistres. Nous utilisons le lien entre les files fluides et le processus du risque pour modéliser la dépendance. Nous calculons les probabilités de survie en utilisant un algorithme numérique et nous traitons le cas où les montants de<p>sinistres et les intersinistres ont des distributions de type phase.<p> / Doctorat en Sciences / info:eu-repo/semantics/nonPublished

Dans un premier temps, nous avons conduit une étude épidémiologique transversale et descriptive dont les objectifs sont de décrire les caractéristiques sociales et professionnelles du personnel du service des urgences et les contraintes psychosociales et organisationnelles du travail. Les résultats de cette enquête, une fois analysés, sont resitués d’une part dans leur environnement politico-institutionnel en décrivant les caractéristiques du système de santé algérien et son évolution et quelques indicateurs reflétant les réponses du système aux défis représentés par la prise en charge de la santé de la population et d’autre part, dans leur environnement théorique et méthodologique, par l’élaboration d’une revue de littérature sur les risques psychosociaux encourus en milieu de soins. Dans un second temps, il nous a semblé propice d’approfondir les résultats de ces investigations épidémiologiques par une étude plus fine des situations de travail. Ceci nous a conduits à observer de près les situations de travail aux urgences moyennant la concrétisation, dans une première phase, d’une intervention ergonomique puis, dans une deuxième phase, l’organisation de Groupes de rencontres du travail (GRT). La démarche ergologique a permis de mieux expliquer les facteurs susceptibles de donner lieu aux conflits de valeurs, aux difficultés de coopérations, aux attitudes hostiles et aux dénis de reconnaissance. Les conséquences majeures de ces risques psychosociaux en sont la démotivation, l’épuisement et le déploiement de stratégies défensives individuelles et collectives. / Initial results have encouraged us to closely observe the work of the emergency situations through the realization of an ergonomic intervention at first and then ergologia (GRT) in a second time. To bring out the elements that may lead to the identification of difficult work situations, we conducted comprehensive and systematic observations leading to the formulation of a local and general diagnosis. We have proposed operational action tracks, one of which is the organization of a meeting of the Working Group (GRT). Writing and putting into words the activity of nurses, caregivers and physicians was difficult. The general tone of the speeches has reported difficulties, collective discomfort or pain at work. The protagonists of work relate currently functions lips and near absence of management. As to the issue of psychosocial risks, the epidemiological study has highlighted the strong professional constraints and the lack of recognition of novice general practitioners and young orderlies.The major consequences are the demotivation and the deployment of defensive strategies as the medicalization of their health seeking an exemption from custody or a transfer to another service.Keywords :Medical and surgical emergencies; Psychosocial risks; Ergonomic; Activity; Psychosocial risks; ergologia; Meeting of the Working Group.

Dans le cadre d'un projet de recherche proposé par l'Institut National de Recherche et de Sécurité (INRS), cette thèse aborde les nanomatériaux manufacturés (NMM) sous l'angle philosophique à la recherche des conditions de possibilité d'une protection juridique efficace et évolutive, des travailleurs en industrie de production et d'utilisation de ces objets. Les NMM sont des objets fondamentalement nouveaux, polémiques et polymorphes avec des propriétés souvent inédites.La première partie de la thèse rend compte des problèmes spécifiques à la production de normes dans l'expérience humaine, plus précisément des normes juridiques sur le travail, puisque ces problèmes impactent les possibilités d'une qualification juridique des NMM et par voie de conséquence la protection des travailleurs. La deuxième partie fait un état des connaissances sur les NMM afin d'identifier les difficultés propres à l'objet, dans la mesure où une connaissance stabilisée est nécessaire à une qualification juridique. La troisième partie propose d'analyser l'activité de travail comme enchâssement de débats de normes qui construisent en amont un monde qualifié par rapport à des choix de vie qui se manifestent sous forme de normes antécédentes, et a fortiori sous la forme de normes juridiques dans l'activité. La thèse considère les NMM à la fois comme des objets d'études pour les sciences de la matière, dont ils sont issus, et comme des objets des sciences humaines et sociales, entendues comme sciences de l'Homme en activité. Ainsi notre apport se retrouve dans l'analyse de l'activité comme outil de maïeutique, source d'une communication entre les différents acteurs de ce domaine. / In the frame of a research project proposed by the French National Institute of Research and Security (INRS), this thesis approaches manufactured nanomaterials (MNM) from the point of view of a philosophical inquiry into the conditions of possiblity of an efficacious and progressive juridical protection of workers in the industry of manufacturing and of the usage of these materials. The MNM are fundamentally new, controversial and often polymorphic objects, with unique properties.The first part of the thesis reports on specific problems in the production of standards in human experience, specifically legal labor standards, since these issues impact the possibilities of a legal characterization of MNM and consequently the protection of workers. The second part proposes an assessment of the state of knowledge concerning the MNM in order to identify the difficulties proper to the material, considering consolidated knowledge is necessary for any qualification in terms of Law.The third part attempts to analyze the activity of work as a grounding of the debate on standards which, from the outset, constructs a world qualified in relation to life choices that become manifest in the shape of already existing standards and a fortiori in the shape of legal standards within the activity of work.This thesis considers MNM as both the object of study for the science of Matter, from which they have sprung, and the object of the social and human sciences, understood as the science of Man in activity. Thus our contribution is to be found within the analysis of the activity as a maieutic implement, and therefore a source of communication between the different actors in this domain.

Underwriting is crucial as it considers whether to take the risk to insurance or not. This thesis describes the underwriting process of industrial risks and factors that have influence on the whole process. The first part is devoted to the description of industrial risks, the assessment of current industrial risks and the development and the current state of the industrial insurance in the Czech Republic. The second part describes the different products of industrial insurance and their underwriting process, with the focus on the underwriters, their rights, duties, qualification and risk management. The final part of this thesis deals with describing the whole process to a particular business, resulting in the insurance offer and the calculation of premium.

Risk management is quite a broad and essential part of project management in construction projects. Often, risk management focuses on perceived risks that can easily be predicted and managed. However, little attention is given to novel risks or risks that are not possible to predict and are unforeseen. Construction projects face these risks repeatedly, and decisions made when they occur are filled with so many discrepancies. The covid-19 virus is an example of a novel virus that no one perceived, which surprised the construction industry. This master thesis explores how organisations in the construction industry in Zimbabwe managed risk related to covid-19 in construction projects and what impact the pandemic had on current risk management practices. This study is an exploratory case study, and semi-structured interviews were utilised to collect data and answer the research questions. The study's findings highlight the major risks related to covid-19 that were faced in construction projects, the particular actions related to risk management that were taken to manage the risk and the impact of covid-19 on risk management frameworks for construction projects in Zimbabwe. Risks posed by the coronavirus to construction projects in Zimbabwe included operational risks, financial risks, productivity risks, supply chain risks, production delay risks and coronavirus infection risks. Mandatory guidelines and ISO procedures mainly influenced the actions taken to manage coronavirus related risks. Measures included introducing extra health safety measures on construction sites such as regular testing and screening and social distancing. Lastly, the impact on construction project risk management frameworks included changes to adapt to the new way of operating with covid-19. These changes include the increase in the budget allocation for novel risks and increased integration of technology in risk management. A small section of the study briefly discusses the Swedish context to capture insights into how the Swedish construction industry was affected by the covid-19 pandemic. Since Sweden did not go into lock down, it was interesting to reflect on how they were affected, and the actions taken to manage covid-19 related risks in that context. / Riskhantering är en ganska bred och väsentlig del av projektledning i byggprojekt. Ofta fokuserar riskhanteringen på upplevda risker som lätt kan förutsägas och hanteras. Men lite uppmärksamhet ägnas unika risker eller risker som inte är möjliga att förutse och är oförutsedda. Byggprojekt möter dessa risker upprepade gånger, och beslut som fattas när de inträffar är fyllda med så många avvikelser. Covid-19-viruset är ett exempel på ett unikt virus som ingen uppfattade, vilket överraskade byggindustrin. Denna masteruppsats undersöker hur organisationer inom byggindustrin i Zimbabwe hanterade risker relaterade till covid-19 i byggprojekt och vilken inverkan pandemin hade på nuvarande riskhanteringsmetoder. Denna studie är en utforskande fallstudie och semistrukturerade intervjuer användes för att samla in data och svara på forskningsfrågorna. Studiens resultat belyser de stora riskerna relaterade till covid-19 som stod inför i byggprojekt, de särskilda åtgärderna relaterade till riskhantering som vidtogs för att hantera risken och effekten av covid-19 på riskhanteringsramverk för byggprojekt i Zimbabwe. Risker som coronaviruset utgör för byggprojekt i Zimbabwe inkluderar operationella risker, finansiella risker, produktivitetrisker, risker kopplade till försörjningskedjan, produktionsföreningrisker och risk för coronavirusinfektion. Obligatoriska riktlinjer och ISO-procedurer påverkade huvudsakligen de åtgärder som vidtogs för att hantera risker relaterade till coronaviruset. Åtgärder omfattade att införa extra hälsosäkerhetsåtgärder på byggarbetsplatser som regelbundna tester och screening och social distansering. Slutligen, effekten på ramverk för riskhantering av byggprojekt inkluderade förändringar för att anpassa sig till det nya sättet att arbeta med covid-19. Dessa förändringar inkluderar ökningen av budgetanslaget för unika risker och ökad integrering av teknik i riskhanteringen. En liten del av studien diskuterar kort den svenska kontexten för att fånga insikter om hur den svenska byggindustrin påverkades av covid-19-pandemin. Eftersom Sverige inte gick in i lockdown var det intressant att reflektera över hur de påverkades och vilka åtgärder som vidtagits för att hantera covid-19 relaterade risker i det sammanhanget.

В магистерской диссертации исследованы проблемы формирования инвестиционного регионального климата. Представлен ряд сценариев по развитию туристской отрасли и рассмотрен один из проектов по формированию туристской деятельности. / In the master's thesis, the problems of the formation of the regional investment climate are investigated. A number of scenarios for the development of the tourism industry are presented and one of the projects for the formation of tourist activity is considered.

No description available.

The purpose of this study was to examine the phenomenon of resilience by means of a literature review (to obtain a theoretical view) and empirical research, particularly to understand why some adolescents with Intellectual disability (ID) were resilient. Firstly, my motivation was curiosity (as teacher of many years of adolescents with ID) about why some youths coped better with the daily challenges that ID brought than some of their peers with ID. Secondly, there was a gap in the existing literature. Although there were studies that, among others, reported the rights of adolescents with ID to quality service provision, the risks that they and their parents/caregivers could expect daily, and challenges and coping skills for teachers/parents and caregivers who worked with these learners every day, I could not locate any South African studies, and only five international studies, that reported the protective resources/processes in adolescents with ID. The purpose of the study was to hear the voices of the adolescents themselves regarding what they, from the reality/context of their life-world, viewed as that which supported them, intrinsically as well as extrinsically, towards resilience. I also asked the teachers (as secondary informants) who worked with the adolescents with ID every day to complete a questionnaire about what (risks as well as protective resources), in their opinion, had an influence on the resilience of these adolescents with ID. I did this qualitative case study with the help of 24 primary informants (that is, adolescents with ID) who all attended schools for the physically and severely intellectually disabled in Gauteng province, South Africa, and 18 of their teachers. On account of the limited literacy of the adolescents with ID, I used a visual participatory research method, namely, draw-and-talk. This involved the primary informants drawing what made them “strong” in life. This was followed by informal conversations where the adolescent informants explained what they had drawn and why. The findings of this study were in agreement with existing literature that reported that resilience was a dynamic, socio-ecological, transactional process between the adolescent with ID (obtaining and using protective resources) and his/her surrounding environment (the ability of the community to supply these resources that could serve the adolescent with ID as buffer against daily risks). The findings included previously non-reported protective processes, namely a supportive social ecology that treated the adolescent as an agentic being (providing opportunities for socially appropriate choices and dreams for the future after school life) and the importance of providing safe spaces for adolescents with ID to be nurtured (children’s homes and/or school hostels). The study also considered what resilience processes there were in the currently existing schools for the physically and severely intellectually disabled. These considerations were aimed at teachers with the hope that they would support teachers and schools to support the adolescent with ID towards resilience. In summary, the study hoped to capacitate teachers, parents, and caregivers to better understand the adolescent with ID and to be aware of how they could support the youth to be resilient. / MEd (Learner Support)--North-West University, Vaal Triangle Campus, 2015

The purpose of the research study was to identify the implications of the licensing processrelated costs for coupling high temperature reactor(s) (HTR) to the SASOL coal-to-liquid (CTL) process (hereafter known as nuclear coal-to-liquid (NCTL)). This was achieved by formulating a licensing plan using SASOL Secunda as a case study. The secondary objectives of the study were: To analyse the national nuclear regulatory (NNR) act, regulation and authorisation, relevant to the licensing of the NCTL production plant; identify variables influencing licensing and evaluating the relative significance from the perspective of relevant stakeholders; and evaluate the magnitude of the activity-base costs. In order to achieve these goals, an in-depth literature review was conducted to understand the application of nuclear licensing and related concepts. These concepts consisted of several key elements, ranging from South Africa’s legal requirements from the perspective of the national energy regulator; environmental impact assessment; NNR’s nuclear installation site license, nuclear installation license – including commissioning and decommissioning. A mixed experimental approach consisting of qualitative (explorative) and quantitative (descriptive) survey designs were utilised in this study to achieve the primary aim and secondary objectives. Three (3) structured measuring instruments such as a telephonic interview, in-depth interviews and self-administered surveys were utilised in this study to collect data. The data collected revealed three (3) short comings. Short comings were addressed thereafter; ten (10) problems were also identified, to which solutions were suggested. From the results of the study and empirical evidence, a quantified assessment of the risk of time and cost of licensing the NCTL production plant was achieved; it was shown that the overall timelines of the licensing plan for the NCTL production plant was estimated at 8 years as suggested by international best practise; total licensing costs was estimated at ZAR 918,599,904.00 in 2013 value. This study concluded with several recommendations in respect of engagement with the NNR, of which the following are important: To gain clarity on the requirements on the content of site safety reports; provide direction on how to apply for multiple nuclear installation licenses for installations for construction on a common site after granting multiple nuclear installation site licenses and public participation process; and distinguish whether the safety authority has the required human resource capable of handling two (2) license applications per year. / MIng (Development and Management Engineering), North-West University, Potchefstroom Campus, 2014