From the Proceedings of the 1978 Meetings of the Arizona Section - American Water Resources Assn. and the Hydrology Section - Arizona Academy of Science - April 14-15, 1978, Flagstaff, Arizona / The city of Tucson, Arizona, the largest city in the U.S. to meet its water needs entirely from diminishing underground sources, is presently experiencing increasing water rates and the political turmoil associated with those increases. With focus upon this increasingly serious problem, production function analysis and static linear programming are used here to estimate the impact of rising energy prices on farm profits, cropping patterns and irrigation water used in the Avra Valley, a periurban irrigated region adjacent to Tucson, in an effort to evaluate the impact of this community upon Tucson 's municipal water demand. It is concluded that as energy prices increase and land is removed from agricultural production within the Avra Valley, Tucson 's economic position will be bolstered in at least three ways: (1) there will be more water available, (2) the price which the city must pay for farmland in order to gain control of the underlying water should be diminished and the quantity of farmland for sale increased, and (3) with fewer people involved in irrigated agriculture, legal conflicts between competing users will be diminished.

Increased possibilities during the last decades for early detection of prostate cancer have sparked research on preventable or treatable risk factors and on improvements in therapy. Treatments of the disease still entail significant side effects potentially affecting men during the rest of their lives. The studies of the present thesis concern different aspects of prostate cancer from etiological risk factors and factors influencing treatment to an improved methodology for the detection of treatment side effects. Papers I, II, both based in the population based cohort ULSAM (Uppsala Longitudinal Study of Adult Men), investigate possible risk factors of prostate cancer with options for intervention: selenium levels and the metabolic syndrome. The phenomenon of competing risk of death from other causes than prostate cancer and its impact on and importance for choice of statistical methods is also exemplified and discussed for the first time in prostate cancer research. -Smokers with low selenium status have an increased future risk of later development of prostate cancer. Influence of genetic variability appears plausible. -The metabolic syndrome and especially its increased waist circumference component are associated with later development of prostate cancer – taking competing risks of death from other causes into account. Papers III and IV using pharmacoepidemiological methods investigate aspects of drug utilisation in prostate cancer using nationwide and international databases. In Paper III factors influencing anti-androgen use in prostate cancer are investigated, both from a prescriber- and patient perspective.  The age and disease risk group of the patient, unsupported scientifically, influence both the prescribers’ choice of dose and the patients’ adherence to treatment. -Adherence, not previously investigated in male cancer patients, was considerably higher than reported for adjuvant breast cancer treatment. Subgroups of men suitable for intervention to increase adherence were identified. Paper IV, investigates the feasibility of improving an established method for screening large adverse drug reactions databases, the proportional reporting ratio (PRR), this by using restricted sub-databases according to treatment area (TA), introducing the concept of PRR-TA. -The PRR-TA method increases the signal-noise relationship of analyses; a finding highly relevant for possibly conserving manual resources in Pharmacovigilance work in a drug-authority setting.

S’appuyant sur un corpus de textes que l’on qualifie normalement de « traités sur l’ambassadeur », cette thèse s’attache à reconstruire la naissance de la diplomatie moderne tout au long d’une période qui va du XIIIe au XVIIe siècle, en essayant d’analyser la manière dont la figure de l’ambassadeur à été élaborée à l’intérieur d’un champ de problématisation qui se caractérise par une imbrication réciproque du droit, de l’éthique et de la politique et va constituer une véritable expérience de la diplomatie.Ce travail s’articule en deux parties. Dans la première il s’agit de comprendre comment la figure de l’ambassadeur a été façonnée sous le profil de son statut juridique, à savoir comme une persona publica chargée d’un officium et devant représenter son mandant, avec les conséquences qui en découlent quant à l’établissement de son pouvoir de négociation, à la définition de ses immunités ainsi qu’à la détermination des honneurs qu’il a le droit de recevoir. L’analyse de ces questions permettra d’apprécier la contribution apportée par notre corpus non seulement à la définition du statut juridique de l’ambassadeur, mais aussi à la formation du nouveau droit des gens destiné à régir l’Europe moderne. La seconde partie s’attache à comprendre comment la figure de l’ambassadeur a été façonnée sous le profil de son statut professionnel : on s’interroge alors sur les fonctions qui lui sont attribuées, sur les moyens qui lui sont fournis et les conditions qui lui sont demandées pour s’en acquitter de la manière la plus efficace, ainsi que sur la problématisation éthique à laquelle son action est soumise. Tout en essayant de faire ressortir la spécificité de l’ambassadeur, cette partie se propose aussi de contribuer à l’étude de la professionnalisation du fonctionnaire public. / Using a collection of texts commonly known as the “treatises on the ambassador”, this research examines the birth and the development of the experience of diplomacy from the 13th to the 17th Century. It aims, in particular, to explore the development of the figure of the ambassador within a field of problematization involving ethics, politics and law.After some methodological and historical remarks, the thesis deals with the development of the status of the ambassador from two perspectives, the legal and the professional. Regarding his legal status, the medieval legal conceptualisation of the role of the ambassador as a genuine public “office”, and that of the diplomatic function as “representation”, are examined. The way in which these conceptualisations help to define the negotiating powers conferred on the ambassador, his immunities and the honours to which he is entitled is then considered. This analysis allows for an investigation of the complex links between the exercise of diplomacy and claims to sovereignty during Europe’s transition from the Middle Ages to Modernity. Regarding his professional status, the thesis reconstructs the functions of the ambassador (particularly in relation to information gathering and negotiation), the means provided for the ambassador to undertake his functions (his salary and the assignment of an escort) and the objective, intellectual or moral qualities required of him. As well as illustrating the techniques which have been required for ambassadorial success since the 15th Century, this analysis offers some hints for studying the professionalization of public officials and the emergence of the modern criteria of political analysis.

No description available.

La dégénérescence maculaire liée à l’âge (DMLA) est la première cause de cécité dans les pays industrialisés. C’est une maladie complexe et multifactorielle ayant des conséquences majeures sur la qualité de vie des personnes atteintes. De nombreux facteurs de risque, génétiques et non génétiques, jouent un rôle important dans la pathogénèse des stades avancés de la DMLA. Les modèles de prédiction développés à ce jour reposent sur un nombre limité de ces facteurs, et sont encore peu utilisés dans la pratique clinique.Ce travail de thèse avait pour premier objectif d’identifier de nouveaux biomarqueurs circulants du risque de DMLA. Ainsi, à partir d’une étude post-mortem basée sur une approche de lipidomique, nous avons identifié les composés lipidiques sanguins les plus prédictifs des concentrations rétiniennes en acides gras polyinsaturés omégas 3 (AGPI w-3). Nous avons développé un modèle de prédiction basé sur 7 espèces de lipides des esters de cholestérol. Ce modèle, obtenu en combinant pénalisation et réduction de la dimension, a ensuite été validé dans des études cas-témoins de DMLA et dans un essai clinique randomisé de supplémentation en AGPI w-3. Ces biomarqueurs pourraient être utiles pour l’identification des personnes à haut risque de DMLA, qui pourraient ainsi bénéficier d’une supplémentation en AGPI w-3.Le deuxième objectif de cette thèse était de développer un modèle de prédiction du risque de progression vers une DMLA avancée à partir de facteurs de risque génétiques, phénotypiques et environnementaux. Une originalité de notre travail a été d’utiliser une méthode de régression pénalisée – un algorithme d’apprentissage automatique – dans un cadre de survie afin de tenir compte de la multicollinéarité entre les facteurs de risque. Nous avons également pris en compte la censure par intervalle et le risque compétitif du décès via un modèle à 3 états sain-malade-mort. Nous avons ensuite validé ce modèle sur une étude indépendante en population générale.Il serait intéressant de valider ce modèle de prédiction dans d’autres études indépendantes en y incluant les biomarqueurs circulants identifiés à partir de l’étude de lipidomique effectuée dans le cadre de cette thèse. Le but final serait d’intégrer cet outil prédictif dans la pratique clinique afin de rendre la médecine de précision une réalité pour les patients atteints de DMLA dans le futur proche. / Age-related macular degeneration (AMD) is the leading cause of blindness in industrialized countries. AMD is a complex and multifactorial disease with major consequences on the quality of life. Numerous genetic and non-genetic risk factors play an important role in the pathogenesis of the advanced stages of AMD. Existing prediction models rely on a restricted set of risk factors and are still not widely used in the clinical routine.The first objective of this work was to identify new circulating biomarkers of AMD’s risk using a lipidomics approach. Based on a post-mortem study, we identified the most predictive circulating lipids of retinal content in omega-3 polyunsaturated fatty acids (w-3 PUFAs). We combined penalization and dimension reduction to establish a prediction model based on plasma concentration of 7 cholesteryl ester species. We further validated this model on case-control and interventional studies. These biomarkers could help identify individuals at high risk of AMD who could be supplemented with w-3 PUFAs.The second objective of this thesis was to develop a prediction model for advanced AMD. This model incorporated a wide set of phenotypic, genotypic and lifestyle risk factors. An originality of our work was to use a penalized regression method – a machine learning algorithm – in a survival framework to handle multicollinearities among the risk factors. We also accounted for interval censoring and the competing risk of death by using an illness-death model. Our model was then validated on an independent population-based cohort.It would be interesting to integrate the circulating biomarkers identified in the lipidomics study to our prediction model and to further validate it on other external cohorts. This prediction model can be used for patient selection in clinical trials to increase their efficiency and paves the way towards making precision medicine for AMD patients a reality in the near future.

Le droit des investissements internationaux et l'Union européenne constituent deux systèmes juridiques qui sont désormais en interaction. La convergence de ces systèmes a été révélée lors de l'entrée en vigueur du Traité de Lisbonne, qui a initié un transfert de compétence en matière d'Investissement Direct Étranger et accorde donc la compétence à l'Union européenne pour conclure de nouveaux accords d'investissement. Dans le cadre d'un chapitre préliminaire, l'analyse tente tout d'abord d'expliquer pourquoi et en quoi le droit des investissements internationaux, tel que résultant de la pratique conventionnelle bilatérale des États membres, et l'Union européenne constituent deux systèmes juridiques en interaction. La méthodologie juridique nécessaire à l'étude des manifestations de la mondialisation juridique est quant à elle décrite. Par la suite, en distinguant les aspects matériels des aspects procéduraux du droit des investissements internationaux, cette thèse s'intéresse aux évolutions des rapports de ces deux systèmes et aux résultats des interactions normatives en cours. La première partie vise à démontrer que le droit matériel des investissements internationaux a fait l’objet d’une approche de la Commission européenne, mise en place dès les années 1990. Quant au droit procédural des investissements internationaux, il ressort que ses liens avec l'Union européenne ont été plus distendus et qu'il n'a fait l’objet que d'un volet qui a été attaché à l’approche européenne du droit matériel des investissements internationaux, à partir de l'entrée en vigueur du Traité de Lisbonne.Sur ces fondements, l'analyse met en exergue le processus d’européanisation en cours du droit des investissements internationaux, qui est relatif au mode de création de la norme internationale, à son contenu et à la participation de l’Union européenne à la procédure de règlement des différends, en vertu d’une procédure arbitrale devant être construite selon la configuration investisseur tiers-Union européenne. / International investment law and the European Union constitute two legal systems that are from now on in interaction. The convergence of these systems has been revealed by the entry into force of the Lisbon Treaty, which has initiated a transfer of competence in the field of Foreign Direct Investment and thus grants competence to the European Union for the conclusion of new investment treaties. Within the framework of a preliminary chapter, the analysis first attempts to explain why and how international investment law, as it results from the bilateral conventional practice of Member States, and the European Union constitute two interacting legal systems. The legal methodology that is necessary for the study of the manifestations of legal globalisation is described. Subsequently, by distinguishing between the substantive and the procedural aspects of International Investment Law, this thesis focuses on the evolutions of the relations between these two systems and on the results of the ongoing normative interactions. The first part aims to demonstrate that substantial international investment law has been the object of an approach from the European Commission, put in place as soon as the 1990s. As for procedural international investment law, it appears that its links with the European Union have been more tenuous and that it has only been the object of a component which has been attached to the European approach of material international investment law, as soon as the entry into force of the Lisbon Treaty. On these foundations, the analysis highlights the ongoing Europeanisation process of International Investment Law, which is related to the mode of creation of the international standard, its content and the participation of the European Union in the procedure of dispute resolution, by virtue of an arbitral procedure which should be constructed according to the foreign investor-European Union configuration.

In this thesis, we investigate several inferential issues regarding the lifetime data from exponential distribution under different censoring schemes. For reasons of time constraint and cost reduction, censored sampling is commonly employed in practice, especially in reliability engineering. Among various censoring schemes, progressive Type-I censoring provides not only the practical advantage of known termination time but also greater flexibility to the experimenter in the design stage by allowing for the removal of test units at non-terminal time points. Hence, we first consider the inference for a progressively Type-I censored life-testing experiment with k uniformly spaced intervals. For small to moderate sample sizes, a practical modification is proposed to the censoring scheme in order to guarantee a feasible life-test under progressive Type-I censoring. Under this setup, we obtain the maximum likelihood estimator (MLE) of the unknown mean parameter and derive the exact sampling distribution of the MLE through the use of conditional moment generating function under the condition that the existence of the MLE is ensured. Using the exact distribution of the MLE as well as its asymptotic distribution and the parametric bootstrap method, we discuss the construction of confidence intervals for the mean parameter and their performance is then assessed through Monte Carlo simulations. Next, we consider a special class of accelerated life tests, known as step-stress tests in reliability testing. In a step-stress test, the stress levels increase discretely at pre-fixed time points and this allows the experimenter to obtain information on the parameters of the lifetime distributions more quickly than under normal operating conditions. Here, we consider a k-step-stress accelerated life testing experiment with an equal step duration τ. In particular, the case of progressively Type-I censored data with a single stress variable is investigated. For small to moderate sample sizes, we introduce another practical modification to the model for a feasible k-step-stress test under progressive censoring, and the optimal τ is searched using the modified model. Next, we seek the optimal τ under the condition that the step-stress test proceeds to the k-th stress level, and the efficiency of this conditional inference is compared to the preceding models. In all cases, censoring is allowed at each change stress point iτ, i = 1, 2, ... , k, and the problem of selecting the optimal Tis discussed using C-optimality, D-optimality, and A-optimality criteria. Moreover, when a test unit fails, there are often more than one fatal cause for the failure, such as mechanical or electrical. Thus, we also consider the simple stepstress models under Type-I and Type-II censoring situations when the lifetime distributions corresponding to the different risk factors are independently exponentially distributed. Under this setup, we derive the MLEs of the unknown mean parameters of the different causes under the assumption of a cumulative exposure model. The exact distributions of the MLEs of the parameters are then derived through the use of conditional moment generating functions. Using these exact distributions as well as the asymptotic distributions and the parametric bootstrap method, we discuss the construction of confidence intervals for the parameters and then assess their performance through Monte Carlo simulations. / Thesis / Doctor of Philosophy (PhD)

Der armenisch-türkische Konflikt ist eines der zentralen Themen in der armenischen Wochenzeitung Agos. Die Karikaturisten Aret Gicir, Ohannes Saskal und Sarkis Pacaci bebildern diesen Konflikt in der Sprache der Karikaturen. Die Zeitung ist dabei auch ein Medium für das kollektive Gedächtnis der Armenier in der Türkei und in der Diaspora. Die vorliegende Arbeit untersucht die Rolle der Karikaturen als Erinnerungsfiguren und die Rolle der Karikaturisten als Erinnerungsträger in den armenischen Medien, hier namentlich die Wochenzeitung Agos, für den kollektiven Konstruktionsprozess. Ohne Medien sind keine Erinnerungen möglich und Karikaturen sind ein Medium der Erinnerung. Die Karikaturisten Aret Gicir, Ohannes Saskal und Sarkis Pacaci verwenden unterschiedliche Techniken und Bildersprachen. Ihre Karikaturen gleichen Graffitis, Piktogrammen oder erotischen Darstellungen, sie sind Botschaften und Symbole einer kulturellen Hinterlassenschaft, so wird beispielsweise der tabuisierte Diskurs der Sexualität mit dem tabuisierten Diskurs des armenischen Genozids in der Türkei verbunden, ein Tabu wird durch ein anderes Tabu ersetzt. Die vorliegende Arbeit zeigt, dass die Karikaturisten die Funktion von modernen armenischen Aschugs, den Minnesängern der Gemeinschaft, übernehmen. Anstatt die Erinnerungen wie früher persönlich von Dorf zu Dorf tragen, oder wie im europäischen Mittelalter von Burg zu Burg, übernimmt diese Reise der Erinnerung die Zeitung Agos, um den Rezipienten mit Botschaften aus der Heimat zu versorgen. Durch die Zeitung wird der Rezipient an die (armenische) Vergangenheit erinnert. An diese Erinnerung wird versucht, die kollektive Gedächtnis der Armenier als Ersatz für das fehlende kommunikative Gedächtnis zu etablieren. / The Armenian-Turkish conflict is among the key subjects treated in the Armenian weekly Agos. The caricaturists Aret Gicir, Ohannes Saskal, and Sarkis Pacaci illustrate this conflict in the language of caricatures. The newspaper is thus also a medium for the collective memory of Armenians in Turkey and in the diaspora. This dissertation examines the role of caricatures as memory figures and the role of the caricaturists as carriers of memory in the Armenian media, here specifically the Agos weekly, for the collective process of construction. Memories are not possible without media, and caricatures are a medium of memory. The caricaturists Aret Gicir, Ohannes Saskal, and Sarkis Pacaci use different techniques and imagery. Similar to graffiti, pictograms, or erotic depictions, their caricatures are messages and symbols of a cultural legacy. The tabooed discourse on sexuality, for example, is related to the tabooed discourse of the Armenian genocide in Turkey; one taboo replaces another. This thesis shows that the caricaturists assume the function of modern Armenian ashughs, the bards of the community. Instead of the earlier practice of transmitting the memories personally from village to village, or from castle to castle, as was done in medieval Europe, this journey of remembrance is carried out by the Agos newspaper in order to provide recipients with messages from home. The newspaper serves to remind recipients of the (Armenian) past. Through this memory, an attempt is made to establish the collective memory of the Armenians as a substitute for the lacking communicative memory.

Les données manquantes sont fréquentes dans les études médicales. Dans les modèles de régression, les réponses manquantes limitent notre capacité à faire des inférences sur les effets des covariables décrivant la distribution de la totalité des réponses prévues sur laquelle porte l'intérêt médical. Outre la perte de précision, toute inférence statistique requière qu'une hypothèse sur le mécanisme de manquement soit vérifiée. Rubin (1976, Biometrika, 63:581-592) a appelé le mécanisme de manquement MAR (pour les sigles en anglais de « manquant au hasard ») si la probabilité qu'une réponse soit manquante ne dépend pas des réponses manquantes conditionnellement aux données observées, et MNAR (pour les sigles en anglais de « manquant non au hasard ») autrement. Cette distinction a des implications importantes pour la modélisation, mais en général il n'est pas possible de déterminer si le mécanisme de manquement est MAR ou MNAR à partir des données disponibles. Par conséquent, il est indispensable d'effectuer des analyses de sensibilité pour évaluer la robustesse des inférences aux hypothèses de manquement.Pour les données multivariées incomplètes, c'est-à-dire, lorsque l'intérêt porte sur un vecteur de réponses dont certaines composantes peuvent être manquantes, plusieurs méthodes de modélisation sous l'hypothèse MAR et, dans une moindre mesure, sous l'hypothèse MNAR ont été proposées. En revanche, le développement de méthodes pour effectuer des analyses de sensibilité est un domaine actif de recherche. Le premier objectif de cette thèse était de développer une méthode d'analyse de sensibilité pour les données longitudinales continues avec des sorties d'étude, c'est-à-dire, pour les réponses continues, ordonnées dans le temps, qui sont complètement observées pour chaque individu jusqu'à la fin de l'étude ou jusqu'à ce qu'il sorte définitivement de l'étude. Dans l'approche proposée, on évalue les inférences obtenues à partir d'une famille de modèles MNAR dits « de mélange de profils », indexés par un paramètre qui quantifie le départ par rapport à l'hypothèse MAR. La méthode a été motivée par un essai clinique étudiant un traitement pour le trouble du maintien du sommeil, durant lequel 22% des individus sont sortis de l'étude avant la fin.Le second objectif était de développer des méthodes pour la modélisation de risques concurrents avec des causes d'évènement manquantes en s'appuyant sur la théorie existante pour les données multivariées incomplètes. Les risques concurrents apparaissent comme une extension du modèle standard de l'analyse de survie où l'on distingue le type d'évènement ou la cause l'ayant entrainé. Les méthodes pour modéliser le risque cause-spécifique et la fonction d'incidence cumulée supposent en général que la cause d'évènement est connue pour tous les individus, ce qui n'est pas toujours le cas. Certains auteurs ont proposé des méthodes de régression gérant les causes manquantes sous l'hypothèse MAR, notamment pour la modélisation semi-paramétrique du risque. Mais d'autres modèles n'ont pas été considérés, de même que la modélisation sous MNAR et les analyses de sensibilité. Nous proposons des estimateurs pondérés et une approche par imputation multiple pour la modélisation semi-paramétrique de l'incidence cumulée sous l'hypothèse MAR. En outre, nous étudions une approche par maximum de vraisemblance pour la modélisation paramétrique du risque et de l'incidence sous MAR. Enfin, nous considérons des modèles de mélange de profils dans le contexte des analyses de sensibilité. Un essai clinique étudiant un traitement pour le cancer du sein de stade II avec 23% des causes de décès manquantes sert à illustrer les méthodes proposées. / Missing data are a common occurrence in medical studies. In regression modeling, missing outcomes limit our capability to draw inferences about the covariate effects of medical interest, which are those describing the distribution of the entire set of planned outcomes. In addition to losing precision, the validity of any method used to draw inferences from the observed data will require that some assumption about the mechanism leading to missing outcomes holds. Rubin (1976, Biometrika, 63:581-592) called the missingness mechanism MAR (for “missing at random”) if the probability of an outcome being missing does not depend on missing outcomes when conditioning on the observed data, and MNAR (for “missing not at random”) otherwise. This distinction has important implications regarding the modeling requirements to draw valid inferences from the available data, but generally it is not possible to assess from these data whether the missingness mechanism is MAR or MNAR. Hence, sensitivity analyses should be routinely performed to assess the robustness of inferences to assumptions about the missingness mechanism. In the field of incomplete multivariate data, in which the outcomes are gathered in a vector for which some components may be missing, MAR methods are widely available and increasingly used, and several MNAR modeling strategies have also been proposed. On the other hand, although some sensitivity analysis methodology has been developed, this is still an active area of research. The first aim of this dissertation was to develop a sensitivity analysis approach for continuous longitudinal data with drop-outs, that is, continuous outcomes that are ordered in time and completely observed for each individual up to a certain time-point, at which the individual drops-out so that all the subsequent outcomes are missing. The proposed approach consists in assessing the inferences obtained across a family of MNAR pattern-mixture models indexed by a so-called sensitivity parameter that quantifies the departure from MAR. The approach was prompted by a randomized clinical trial investigating the benefits of a treatment for sleep-maintenance insomnia, from which 22% of the individuals had dropped-out before the study end. The second aim was to build on the existing theory for incomplete multivariate data to develop methods for competing risks data with missing causes of failure. The competing risks model is an extension of the standard survival analysis model in which failures from different causes are distinguished. Strategies for modeling competing risks functionals, such as the cause-specific hazards (CSH) and the cumulative incidence function (CIF), generally assume that the cause of failure is known for all patients, but this is not always the case. Some methods for regression with missing causes under the MAR assumption have already been proposed, especially for semi-parametric modeling of the CSH. But other useful models have received little attention, and MNAR modeling and sensitivity analysis approaches have never been considered in this setting. We propose a general framework for semi-parametric regression modeling of the CIF under MAR using inverse probability weighting and multiple imputation ideas. Also under MAR, we propose a direct likelihood approach for parametric regression modeling of the CSH and the CIF. Furthermore, we consider MNAR pattern-mixture models in the context of sensitivity analyses. In the competing risks literature, a starting point for methodological developments for handling missing causes was a stage II breast cancer randomized clinical trial in which 23% of the deceased women had missing cause of death. We use these data to illustrate the practical value of the proposed approaches.

Indiana University-Purdue University Indianapolis (IUPUI) / The Iraq War and the War on Terror were pivotal issues in the presidential race for the White House in 2004. Competing frames about the meaning of September 11, 2001, terrorism, and American power were constructed by the rival candidates and established a limited debate that marginalized alternative interpretations of war and peace. It is likely that the dilemma over U.S. forces in Iraq and the War on Terror will continue to be a major issue in the upcoming 2008 Presidential Election. Therefore, the campaign speeches of the presidential candidates, President George W. Bush and Senator John Kerry, during the 2004 Election regarding terrorism were important to understanding the themes that initiated public debate in the U.S. about the conflict in Iraq and the War on Terror. In this document analysis, these candidates’ public addresses illustrated how the role of the U.S. power to combat terrorism shaped a particular perspective about the post-9/11 world. Ideas that challenged “official” debate about war and national security were excluded from mainstream media coverage of the campaign. In order to examine the narrow debate over terrorism and how alternative “ways of seeing” war have been and continue to be marginalized, this study compared how the candidates framed the war in contrast to anti-war voices. Cindy Sheehan, who is an emergent leader in the peace and social justice movement, and more “official” voices of dissent like Representative Dennis Kucinich, have criticized “official” framing of the war. Dissenting perspectives about the Iraq War and the War on Terror invite a different understanding about U.S. hegemony, terrorism, and the consequences of the War on Terror for foreign and domestic policies. The impact of the war upon domestic policy and national crises, such as the widely televised and heavily criticized federal response to Hurricane Katrina Summer 2005, were examined to explore how domestic crises undermine “official” framing of the Iraq War and the War on Terror and empower alternative understandings of war and peace.