Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2018-01-16T17:59:55Z No. of bitstreams: 1 ClaraVivianeSilvaDaCosta_DISSERT.pdf: 2160720 bytes, checksum: 6f0b40fd44b02d69cd2f7b13af06ba85 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2018-01-22T11:22:59Z (GMT) No. of bitstreams: 1 ClaraVivianeSilvaDaCosta_DISSERT.pdf: 2160720 bytes, checksum: 6f0b40fd44b02d69cd2f7b13af06ba85 (MD5) / Made available in DSpace on 2018-01-22T11:22:59Z (GMT). No. of bitstreams: 1 ClaraVivianeSilvaDaCosta_DISSERT.pdf: 2160720 bytes, checksum: 6f0b40fd44b02d69cd2f7b13af06ba85 (MD5) Previous issue date: 2017-07-28 / Objetivou-se avaliar a substitui??o da suplementa??o da ractopamina pelo uso dos ?leos de c?rtamo e coco na dieta de su?nos em termina??o. Foram utilizados 24 su?nos machos castrados mesti?os com peso m?dio de 78,00 ? 8,76 kg, distribu?dos em delineamento em blocos casualizados, com quatro tratamentos e seis repeti??es. Os tratamentos constitu?ram de Ra??o Basal (RB); RB + 10 ppm de ractopamina; RB + 4g de ?leo de coco e RB + 4g de ?leo de c?rtamo. Avaliou-se os par?metros de desempenho, peso dos ?rg?os, caracter?sticas de carca?a, qualidade da carne e perfil de ?cidos graxos por cromatografia gasosa. Os animais alimentados com ractopamina e o ?leo de c?rtamo apresentaram melhor convers?o alimentar. O maior ganho de peso foi observado (p ? 0,05) nos animais suplementados com o ?leo de coco e a ractopamina. Em rela??o ao peso dos ?rg?os, observou-se redu??o (p ? 0,05) no peso do est?mago dos animais suplementados com o ?leo de coco. Constatou-se redu??o significativa (p ? 0,05) na espessura de toucinho no ponto 3 dos animais suplementados com ?leo de c?rtamo e para ?rea de olho de lombo houve efeito significativo (p ? 0,05) nos alimentados com ractopamina. Os demais par?metros de carca?a n?o foram observados (p > 0,05) diferen?a entre os tratamentos utilizados. Nas avalia??es do perfil de ?cidos graxos, observou-se maior concentra??o (p ? 0,05) de C12:0 e C14:0 no tecido adiposo dos su?nos suplementados com ?leo de coco. No m?sculo Longissimus dorsi houve o enriquecimento com ?-9, redu??o do C18:1n9t nos animais suplementados com ?leo c?rtamo e eleva??o de C16:1 nos suplementados com ?leo de coco. Recomenda-se a utiliza??o do ?leo de c?rtamo em substitui??o a ractopamina, por apresentar melhor convers?o alimentar, reduzir a espessura de toucinho e promover o enriquecimento da carne com ?-9. / This study aimed to evaluate the replacement of supplementation of ractopamine by the use of safflower and coconut oils in pig diet termination. 24 crossbred barrows were used with an average weight of 78.00 ? 8.76 kg, distributed in a randomized block design with four treatments and six replications. The treatments constituted of Basal Ration (BR); BR + 10 ppm of ractopamine; BR + 4g of coconut oil and BR + 4g of safflower oil. Assessed the performance parameters, organ weight, carcass characteristics, meat quality and profile of fatty acids by gas chromatography. Animals fed ractopamine and safflower oil showed better feed conversion. The highest weight gain was observed (p ? 0.05) in the animals supplemented with coconut oil and ractopamine. In relation to the weight of the organs, it was observed reduction (p ? 0.05) in the stomach weight of animals supplemented with coconut oil. There was a significant (p ? 0.05) reduction in the backfat thickness at point 3 of the animals supplemented with safflower oil and in the loin eye area there was a significant effect (p ? 0.05) on the ractopamine fed. The other carcass parameters were not observed (p > 0.05) difference between the treatments used. In the evaluation of the fatty acid profile, a higher concentration (p ? 0.05) of C12:0 and C14:0 was observed in the adipose tissue of the pigs supplemented with coconut oil. In the longissimus muscle dorsi there was the enrichment with ?-9, reduction of C18:1n9t in animals supplemented with oil safflower and elevation of C16:1 in supplemented with coconut oil. The use of safflower oil is recommended to replace the ractopamine, for presenting better feed conversion, reduce the backfat thickness and promote meat enrichment with ?-9.

Made available in DSpace on 2014-12-17T14:13:46Z (GMT). No. of bitstreams: 1 MariaFPB_TESE.pdf: 831507 bytes, checksum: 16c85e1c11c77cb917991582252e33d1 (MD5) Previous issue date: 2013-03-20 / A S?ndrome de Berardinelli-Seip (SBS) ? um dist?rbio raro do metabolismo dos lip?dios, caracterizada pela aus?ncia quase total de tecido adiposo subcut?neo, hipertrigliceridemia, hipoleptinemia e diabetes insulino resistente ou lipoatr?fico. Sua etiologia envolve implica??es hipotal?micas, altera??es nos receptores de insulina e muta??es nos genes AGPAT2, Gng3lg, CAV1 e PTRF. O tecido adiposo secreta diversas subst?ncias, tais como: leptina, resistina, adiponectina, ester?ides, TNF , IL-6, PAI-1, angiotensinog?nio, IGF-1. Muitas delas est?o associadas ao diabetes mellitus tipo 2, obesidade e hipertens?o. Os PPARs s?o fatores transcricionais pertencentes ? superfam?lia de receptores nucleares ligantes ativados. Sabe-se que o PPAR , ? importante para o metabolismo lip?dico e glic?dico e que o ligante natural do PPAR ? derivado do ?cido graxo. Nesse sentido, foram avaliados 24 pacientes portadores da SBS, provenientes do Estado do Rio Grande do Norte, com a mediana das idades de 18,5 anos (0,55 a 47 a), sendo 9 (37,5 %) do g?nero masculino e 15 (62,5 %) do g?nero feminino. Quanto ao grupo ?tnico, foram classificados em caucas?ides (brancos) 21 (87,5 %) e negr?ides 3 (12,5 %) pacientes. Foram feitas avalia??es cl?nico-endocrinol?gica, bioqu?mica, hormonal, molecular e o estudo dos polimorfismos Adiponectina ADIPOQ, PPARγ2 Pro12Ala, LPL-PvuII, APOC3-SstI e LDLR-AvaII em portadores da SBS. Nesta popula??o n?s n?o encontramos nenhuma associa??o de par?metros lip?dicos e glic?dicos com os polimorfismos LPL-PvuII, APOC3-SstI e LDLR-AvaII. Por?m, observamos associa??o entre Adiponectina ADIPOQ e PPARγ2 Pro12Ala e n?veis lip?dicos mais elevados, sugerindo um papel biol?gico para estes fatores, indicando estudos mais aprofundados

Made available in DSpace on 2014-12-17T14:16:27Z (GMT). No. of bitstreams: 1 SamaraFLG_DISSERT_Parcial.pdf: 514844 bytes, checksum: d16ddfb7e1a5d90206d072660fcd0689 (MD5) Previous issue date: 2009-08-31 / Overweight and obesity are defined as abnormal or excessive fat accumulation that may impair health. Obesity significantly increases the risk of developing numerous medical conditions, besides is associated with shortened life span. The objective of this study was to evaluate the anthropometric measurements and lipid profile in adult overweight and obese subjects residents in the state of Rio Grande do Norte. The methodology was the analysis of certain biochemical parameters in serum of individuals and a physical evaluation that consisted of measurements of blood pressure and anthropometric data. In addition, the volunteers of the research answered a questionnaire about personal, social and clinical data. 1741 samples were collected, of which 432 (24,8%) were obese. Of these, 280 were selected to participate in the study, including 118 (42,1%) men and 162 (57,9%) women. Of the remaining 1309 individuals, 731 (55,8%) were overweight. Among them, 179 (24.5%) were analyzed in this study, with 56,4% female. Of the remaining 578 normal individuals, 143 were selected as controls in the research. Amid the obese, overweight and eutrophic, there were respectively 10% vs 5% vs 5,6% of diabetics, 92,1% vs 85,5% vs 68,7% of dyslipidemics and 38,6% vs 22,3% vs 15,6% of hypertensive patients. The degree of obesity presented by the participants was varied, with the majority (72,8%) fall into grade I obese, 22,9% (64) in grade II and only 4,3% (12) in grade III. Mean anthropometric participants showed statistically significant differences between groups eutrophic, overweight and obese on the BMI, WC, WHR and %BF and between sexes in CC, WHR and %BF. As the mean serum biochemical parameters to evaluate the lipid profile showed significant differences between groups eutrophic, overweight and obese, unless the exception of HDL among overweight and obese. The significance level was 5% (p <0.05) / O sobrepeso e a obesidade s?o definidos como o ac?mulo de gordura anormal ou excessivo que possa causar danos ? sa?de, aumentando expressivamente o risco de desenvolvimento de numerosas patologias, al?m de estarem associados ? diminui??o da expectativa de vida. O objetivo do presente trabalho ? avaliar as medidas antropom?tricas e o perfil lip?dico de indiv?duos adultos obesos e com sobrepeso residentes no Estado do RN. A metodologia adotada foi a an?lise de par?metros bioqu?micos determinados no soro dos volunt?rios e uma avalia??o f?sica que constou de medi??es de press?o arterial e dados antropom?tricos. Os volunt?rios da pesquisa ainda responderam a um question?rio sobre dados pessoais, sociais e cl?nicos. Foram coletadas 1741 amostras, das quais 432 (24,8%) eram de obesos. Destes, 280 foram selecionados para participar da pesquisa, entre eles 118 (42,1%) homens e 162 mulheres (57,9%). Dos 1309 volunt?rios restantes, 731 (55,8%) apresentaram sobrepeso. Dentre eles, 179 (24,5%) foram analisados nesta pesquisa sendo 56,4% do g?nero feminino. Dos 578 volunt?rios eutr?ficos remanescentes, 143 foram selecionados como controle da pesquisa. Em meio aos obesos, sobrepesos e eutr?ficos, havia, respectivamente, 10% vs 5% vs 5,6% de diab?ticos, 92,1% vs 85,5% vs 68,7% de dislipid?micos e 38,6% vs 22,3% vs 15,6% de hipertensos. O grau de obesidade apresentado pelos volunt?rios foi variado, com a maioria (72,8%; n = 204) se encaixando em obesos grau I, 22,9% (64) em grau II e apenas 4,3% (12) em grau III. As m?dias antropom?tricas dos volunt?rios indicaram diferen?as estatisticamente significantes entre os grupos eutr?fico, sobrepeso e obeso quanto ao IMC, CC, RCQ e %GC, e entre os g?neros quanto a CC, RCQ e %GC. Assim como as m?dias dos par?metros bioqu?micos s?ricos que avaliam o perfil lip?dico indicaram diferen?as significativas entre os grupos eutr?fico, sobrepeso e obeso, salvo exce??o do HDL entre os sobrepesos e obesos. O n?vel de signific?ncia adotado foi de 5% (p < 0,05)

Made available in DSpace on 2014-12-17T14:20:08Z (GMT). No. of bitstreams: 1 PatriciaMM_DISSERT.pdf: 1198600 bytes, checksum: 3134b80612edf94f7e2b612f2a6c95fa (MD5) Previous issue date: 2012-10-08 / This research aims to investigate the effectiveness of the legal labor phenomenon in contemporary capitalism as rectifier element of the contradictions between capital and labor. From the analysis of legislative developments - state and business - and court decisions related to the category of freight transport is expected to determine the protectionist stiffness proclaimed by the institutional structure of labor in Brazil, considered by the hegemonic discourse as political-economic factor that prevents growth. It is intended to unravel the relationships between political and civil society, studying the internal contradictions and ideological influence among these spaces, with theoretical support in Marx and Gramsci. The function of this research is to test the premise that the protectionist discourse is a rational action of capitalism and the organic intellectuals of political society in order to achieve hegemony and hide the real contradictions between capital and labor, in addition to also assist in the discussion on deregulation and easing in Brazil. The analysis points to the confirmation of our premise, since the evolution of the legal phenomenon in the transport sector was charging toward the neoliberal project / Esta pesquisa se prop?e investigar a efetividade do fen?meno jur?dico trabalhista no capitalismo atual como elemento retificador das contradi??es entre capital e trabalho. A partir da an?lise da evolu??o legislativa - estatal e negocial - e de decis?es judiciais relacionadas ? categoria de transportes de carga, espera-se averiguar a proclamada rigidez protecionista da estrutura institucional trabalhista no Brasil, considerada pelo discurso hegem?nico pol?tico-econ?mico como fator que impede o crescimento. Pretende-se desvendar as rela??es entre sociedade pol?tica e sociedade civil, estudando as contradi??es internas e a influ?ncia ideol?gica entre estes espa?os, com aporte te?rico em Marx e Gramsci. A fun??o da investiga??o ? testar a premissa que o discurso protecionista ? uma a??o racional do capitalismo e dos intelectuais org?nicos da sociedade pol?tica, a fim de alcan?ar hegemonia e ocultar as contradi??es reais entre capital e trabalho; al?m de tamb?m auxiliar na discuss?o sobre a desregulamenta??o e a flexibiliza??o no Brasil. A an?lise aponta para a confirma??o da nossa premissa, posto que a evolu??o do fen?meno jur?dico no setor de transporte de carga foi na dire??o do projeto neoliberal

Made available in DSpace on 2014-12-17T14:27:07Z (GMT). No. of bitstreams: 1 RobertaFAP.pdf: 529103 bytes, checksum: 23d47be5484595d8128d725d89c8e411 (MD5) Previous issue date: 2006-08-18 / The study undertakes the analysis of the constitutional warranty principle of the Absolute Priority of the children and adolescents fundamental rights concerning to the sense, reach, content, addressees and effectiveness. Then, we begin with the study of the Constitution, text where is inserted the principle on examination, opportunity on which it verifies the concept and conceptions of the Constitution, theories, functions, it normative power and the constitutional feeling. Soon after, the fundamental rights theory is analyzed, focusing your origin, importance, functions, protection, restrictions, duties, characteristics and effectiveness. Then, it is led in general to the place of the principles, moment that leans to their concept, evolution, functions, classification and characteristics. Finally, it is appreciated the principle of the Absolute Priority approaching to the meaning and reach, the normative force and importance, historical precedents, materialize rules, addressees and its normative power and enforcement / O estudo aqui compreende a an?lise do princ?pio de garantia constitucional da Prioridade Absoluta dos direitos fundamentais de crian?as e de adolescentes no que se refere ao seu sentido, alcance, conte?do, destinat?rios e efic?cia. Assim, inicia-se com o estudo da Constitui??o, texto no qual se encontra inserido o princ?pio em exame, oportunidade em que se verifica o conceito e concep??es da Constitui??o, teorias, fun??es, for?a normativa e sentimento constitucional. Em seguida, analisa-se a teoria dos direitos fundamentais, enfocando sua origem, fundamentabilidade, fun??es, prote??o, restri??es, deveres, caracter?sticas e efic?cia. Depois, envereda-se na seara dos princ?pios em geral, momento em que se debru?a sobre o conceito, evolu??o, fun??es, classifica??o e caracter?sticas. Finalmente, aprecia-se o princ?pio da Prioridade Absoluta, abordando o significado e alcance, a for?a normativa e fundamentabilidade, precedentes hist?ricos, regras concretizadoras, destinat?rios e for?a vinculativa e aplicabilidade

Made available in DSpace on 2014-12-17T14:27:11Z (GMT). No. of bitstreams: 1 MarianaS_capa_a_resumo.pdf: 271175 bytes, checksum: 926338aea632e3cbde76e722465b1d6e (MD5) Previous issue date: 2009-09-10 / Instituto Brasileiro de Petr?leo, G?s e Biocombust?veis / The oil activities in Brazil had been started in an intensive way in the end of the 30 s and in the beginning of the 40 s. Many of the brazilians fields discovered in the past are nowadays in decline. They are called &#8213;mature fields&#8214;. These fields, because of the decline situation that characterizes them, are not interesting for the majors. The majors want the big fields and big productions. On the other hand, they could be interesting for the small and medium enterprises. The mature oil fields are instruments of development, they have oil and the oil production is an activity connected with many social and economics benefits: jobs, taxes, royalties, etc. The Brazilian State, in this context, needs to realize actions to promote the activities in the mature oil fields, especially with the work of the small and mediums enterprises. Many of the onshore brazilian mature fields are located at the Northeast, a region matched by many social and economic problems. The activities in the mature fields of the Northeast Region could solve some of its problems. The present research analyses the mature oil fields and its situations in Brazil, making criticisms and suggestions. The methodology adopted is theoretical and descriptive, with literature review, case law and legislation (Constitui??o Federal de 1988, &#8213;Law of the Oil&#8214;). This research examines the following points: mature fields rounds and its documents, name and definition of the mature fields, definition of small and medium enterprises, environmental aspects, concentration of certain activities of the sector and the royalties / As atividades do petr?leo no pa?s foram iniciadas de forma mais intensa no final dos anos 30 e in?cio dos anos quarenta. Muitos dos campos de petr?leo descobertos no passado hoje se encontram em decl?nio produtivo, s?o os chamados &#8213;campos maduros de petr?leo&#8214;. Estes campos, em decorr?ncia do decl?nio em sua produ??o, n?o se revelam interessantes ?s grandes empresas de petr?leo. Grandes empresas desejam grandes campos e grandes produ??es. Por outro lado, podem os campos maduros se revelar interessantes aos empreendedores de menor porte. Os campos maduros, ainda que em decl?nio, possuem petr?leo e o petr?leo ? recurso energ?tico demasiadamente relevante. A produ??o de petr?leo, mesmo em campos declinantes, ? atividade ligada a in?meros benef?cios sociais e econ?micos: gera empregos direitos e indiretos, promove o recolhimento de tributos, o pagamento de royalties, dentre outros. O Estado brasileiro, neste contexto, necessita realizar a??es que promovam a continua??o da produ??o em campos maduros, especialmente atrav?s do ingresso de empreendedores de menor porte. Muitos dos campos maduros onshore se encontram no Nordeste brasileiro, regi?o marcada por s?rios problemas econ?micos e sociais e por uma intensa desigualdade. As atividades de produ??o de petr?leo nos campos maduros nordestinos podem resolver alguns destes problemas, fato este que ressalta a import?ncia do fomento ? continua??o destas atividades nestes campos. A presente pesquisa, atentando para a relev?ncia do fomento ? continua??o das atividades desenvolvidas nos campos maduros de petr?leo, se debru?a sobre seu estudo e atual realidade, formulando cr?ticas e sugest?es, em especial no que diz respeito ? entrada de empreendedores de menor porte no setor. Para isto, utiliza a metodologia do tipo te?rico-descritiva, com an?lise bibliogr?fica, jurisprudencial e normativa. Neste ?ltimo caso, a Constitui??o Federal de 1988 e a &#8213;Lei do Petr?leo&#8214; se destacam. S?o aqui especificamente analisadas as licita??es at? hoje efetuadas em torno de ?reas contendo campos maduros de petr?leo, seus editais e contratos de concess?o. A pesquisa em quest?o ainda se ocupa das seguintes tem?ticas: conceito e denomina??o dos campos de petr?leo com produ??o declinante, necessidade de formula??o de um conceito para a express?o &#8213;empreendedores petrol?feros de menor porte&#8214;, licenciamento ambiental no setor do petr?leo, passivos ambientais atinentes aos campos maduros, concentra??o de determinadas atividades do setor junto ? Petrobras e royalties e necessidade de sua cobran?a em percentual reduzido

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2015-11-26T13:12:52Z No. of bitstreams: 1 AlexandroTeixeiraGomes_TESE.pdf: 22462974 bytes, checksum: 869b89b9949816c057b96f691600957d (MD5) / Approved for entry into archive by Elisangela Moura (lilaalves@gmail.com) on 2015-11-26T14:23:30Z (GMT) No. of bitstreams: 1 AlexandroTeixeiraGomes_TESE.pdf: 22462974 bytes, checksum: 869b89b9949816c057b96f691600957d (MD5) / Made available in DSpace on 2015-11-26T14:23:30Z (GMT). No. of bitstreams: 1 AlexandroTeixeiraGomes_TESE.pdf: 22462974 bytes, checksum: 869b89b9949816c057b96f691600957d (MD5) Previous issue date: 2014-08-15 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / A An?lise Textual dos Discursos tem sua origem no ?mbito da Lingu?stica Textual e se prop?e a estudar a produ??o co(n)textual de sentido fundamentada na an?lise de textos concretos, oferecendo elementos para o entendimento do texto como uma pr?tica discursiva analisado ? luz de determinados planos ou n?veis de an?lise lingu?stica. Nesse sentido, ? nosso prop?sito, nesta investiga??o, estudar o fen?meno da responsabilidade enunciativa na senten?a judicial condenat?ria. Para tanto, seguimos os aportes te?ricos da An?lise Textual dos Discursos (ADAM, 2011) e da Lingu?stica Enunciativa, a partir de v?rios autores, entre eles, Rabatel (2003, 2004, 2005, 2008, 2009, 2010), N?lke (2001, 2005, 2009, 2013), N?lke, Fl?ttum e Nor?n (2004), Guentch?va (1994, 1996, 2011) e Guentch?va et al. (1994). Nessa dire??o, investigamos a responsabilidade enunciativa, atrav?s de uma escala que compreende o fen?meno a partir de quatro grada??es, cada uma com um tipo de ponto de vista (PdV) e com elos que podem marcar a assun??o ou o distanciamento do ponto de vista. No que concerne ? abordagem jur?dica da tese, nossa ancoragem te?rica segue v?rios autores, entre eles, Petri (1994), Soto (2001), ?lvarez (2002), Alves (2003), Cornu (2005), Albi (2007), Bittar (2010), Asensio e Polanco (2011), L?pez Samaniego (2006), Montol?o e L?pez Samaniego (2008), Montol?o (2002, 2010, 2011, 2012, 2013), Colares (2010), Prieto (2013), Louren?o e Rodrigues (2013) e Rodrigues, Passeggi e Silva Neto (2014). Nosso corpus se constitui de 13 senten?as condenat?rias provenientes de processos criminais oriundos da comarca de Currais Novos-RN, conclu?dos no ano de 2012. Os resultados revelam como o juiz, a partir de v?rias inst?ncias enunciativas, constr?i a senten?a judicial, o que nos permitiu compreender a configura??o da (n?o) assun??o da responsabilidade enunciativa no g?nero discursivo / textual senten?a judicial condenat?ria. Como conclus?es, percebemos que as unidades discursivas s?o perspectivadas ora, a partir da assun??o, ora, a partir da n?o assun??o dos PdV pelas inst?ncias enunciativas, o que orienta a organiza??o argumentativa do produtor do texto e seus prop?sitos comunicativos. Com isso, o juiz cria e/ou modifica valores e cren?as, induz e/ou orienta seu interlocutor podendo demonstrar objetividade e/ou preservar sua face atrav?s de constru??es mediatizadas ou podendo engajar-se pelo dito atrav?s da assun??o da responsabilidade enunciativa do conte?do proposicional do enunciado. Pelo exposto, reafirmamos nosso entendimento de que a (n?o) assun??o da responsabilidade enunciativa se configura como mecanismo argumentativo fortemente marcado pelo produtor do texto com vistas a seus prop?sitos comunicativos. A senten?a, portanto, constr?i-se nesse jogo de assun??o e/ou n?o assun??o dos enunciados de acordo com a orienta??o argumentativa e com os objetivos do produtor do texto. / The Textual Analysis of Discourse has its origin in Text Linguistics and it aims at studying the co(n)text meaning production based on the analysis of concrete texts by offering elements to the understanding of the text as a discourse practice throughout the plans or levels of linguistic analysis. In this perspective, we intend to investigate the enunciative responsibility phenomenon in the sentencing court judgment. To do so, we review the theoretical contributions of Textual Analysis of Discourse (ADAM, 2011) and the Enunciative Linguistics from various authors, among them, Rabatel (1998, 2003, 2004, 2005, 2008, 2009, 2010), N?lke (2001, 2005, 2009, 2013), N?lke, Fl?ttum and Nor?n (2004), Guentch?va (1994, 1996) and Guentch?va et al. (1994). In this direction, we investigate the enunciative responsibility through a range that comprises the phenomenon from four gradations, each one with a kind of point of view (PoV) and with links that may mark the assumption or the distance from the point of view. Regarding the legal approach of the thesis, our theoretical anchoring follows several authors, among them, Petri (1994), Soto (2001), Alvarez (2002), Alves (2003), Cornu (2005), Albi (2007), Bittar (2010), Asensio and Polanco (2011), L?pez Samaniego (2006), L?pez Montol?o and Samaniego (2008), Montol?o (2002, 2010, 2011, 2012, 2013), Sterling (2010), Prieto (2013), Lawrence and Rodrigues (2013) and Rodrigues, Passeggi and Silva Neto (2014). Our corpus is composed of 13 sentences from criminal cases arising from the district of Currais Novos-RN, completed in 2012. The results reveal how the judge, from various enunciative instances, builds the court decision, which allowed us to understand the configuration of (non) assumption of enunciative responsibility in the sentencing court judgment discourse genre. In conclusion, we perceive that the discourse units are envisaged or through the assumption, or the non assumption of PoV by the enunciative instances, what guides the producer organization argumentative text and his (her) communicative purposes. With that, the judge creates and/or modifies values and beliefs, induces and/or guides his (her) interlocutor by being able to demonstrate objectivity and/or preventing his (her) face through the mediated constructions or engage through the assumption of the enunciative responsibility of the propositional content of an utterance. In short, we reaffirm our belief that the (non) assumption of the enunciative responsibility configures as an argumentative mechanism strongly marked by the producer of the text with a view to their communicative purposes. The sentence, therefore, is constructed in this game of taking and/or not taking of statements according to argumentative orientation and the objectives of the text producer.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2015-12-15T17:40:31Z No. of bitstreams: 1 GabrielaSalvadorOurique_DISSERT.pdf: 9103307 bytes, checksum: d30f3a32f57ad778a4352a7ac2b010f0 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2015-12-28T21:29:28Z (GMT) No. of bitstreams: 1 GabrielaSalvadorOurique_DISSERT.pdf: 9103307 bytes, checksum: d30f3a32f57ad778a4352a7ac2b010f0 (MD5) / Made available in DSpace on 2015-12-28T21:29:28Z (GMT). No. of bitstreams: 1 GabrielaSalvadorOurique_DISSERT.pdf: 9103307 bytes, checksum: d30f3a32f57ad778a4352a7ac2b010f0 (MD5) Previous issue date: 2014-07-18 / Dengue (DENVE) ? um importante v?rus pat?geno pertencente ao g?nero Flavivirus. O genoma do v?rus da Dengue, ? constitu?do de RNA envelopado de fita simples e sentido ?nico (+), possui aproximadamente 10.7-11 Kb. O RNA de DENV ? traduzido como uma ?nica poliprote?na. Esta poliprote?na, ? traduzida em 3 prote?nas estruturais (C, prM e E) e 7 n?o estruturais (NS1, NS2A, NS2B, NS3, NS4A, NS4B e NS5). A prote?na NS3 ? uma prote?na multifuncional que al?m de promover o processamento da poliprote?na do genoma viral, tamb?m possui atividade helic?sica, NTP?sica e RTP?sica. A NS3 precisa de cerca de 40 res?duos da prote?na NS2B (que age como cofator) para realizar suas atividades. Os tratamentos de DV atuais s?o principalmente sintom?ticos, n?o existem vacinas eficazes aprovadas e comercializadas, nem drogas antivirais dispon?veis para proteger ou curar a doen?a da dengue. O inibidor tetrapept?dico Bz-Nle-Lys-Arg-Arg-H, (com Ki de 5,8-7,0 ?M) tem sido apresentado na literatura como um potente inibidor da protease NS3 em DV. Sendo uma estrat?gia inteligente para o tratamento da Dengue. O presente trabalho objetivou estudar as intera??es do ligante junto ao s?tio ativo para fornecer uma vis?o mais clara e aprofundada dessas intera??es. Para tal desenvolveu-se um estudo in silico, com utiliza??o de c?lculos de mec?nica qu?ntica, baseada na Teoria do Funcional da Densidade (DFT), com aproxima??es do Gradiente Generalizado (GGA) para descri??o dos efeitos de correla??o e troca. A energia de intera??o de cada amino?cido do s?tio de liga??o, com o ligante foi calculada com base no m?todo de fragmenta??o molecular com capas conjugadas (MFCC). Al?m da energia, foram calculadas as dist?ncias, tipos de intera??es moleculares e grupos at?micos envolvidos. Os modelos te?ricos utilizados foram satisfat?rios e demonstraram uma descri??o mais precisa com a utiliza??o da constante diel?trica ?=20 e 80. Os resultados demonstram que a energia de intera??o do sistema atingiu a converg?ncia em 13,5A. Dentro desse raio de intera??o os res?duos mais importantes foram identificados. Met49, Met84 e Asp81 realizam intera??es de hidrog?nio. Os res?duos Asp79 e Asp75 apresentam elevada energia de atra??o. J? res?duos como Arg54, Arg85 e Lys 131 realizam intera??es de hidrog?nio pr?ximas com o ligante, por?m, aparecem no gr?fico do BIRD possuindo elevada energia de repuls?o com o inibidor. Os resultados tamb?m destacam a import?ncia do res?duo Tyr161 e o envolvimento da tr?ade catal?tica constitu?da por Asp75, Ser135 e His51. / Dengue virus is an important patogen that causes Dengue desease in all world, and belongs to Flavivirus gender. The virus consists of enveloped RNA with a single strand positive sense, 11Kb genome. The RNA is translated into a polyprotein precursor, wich is cleaved into 3 structural proteins (C, prM e E) and 7 non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B e NS5). The NS3 is a multifunctional protein, that besides to promote the polyprotein precursor cleavage, also have NTPase, helicase and RTPase activity. The NS3 needs a hydrophilic segment of 40 residues from the transmembrane NS2B protein (who acts like cofator) to realize this functions. Actually, there's no vacines available on the market, and the treatment are just symptomatic. The tetrapeptide inhibitor Bz-Nle-Lys-Arg-Arg-H (Ki de 5,8-7,0 M) was showed as a potent inhibitor ? for NS3prot in Dengue virus. That is a inteligent alternative to treat the dengue desease. The present work aimed analyse the interactions of the ligand bounded to the activity site to provid a clear and depth vision of that interaction. For this purpouse, it was conducted an in silico study, by using quantum mechanical calculations based on Density Functional Theory (DFT), with Generalized Gradient approximation (GGA) to describe the effects of exchange and correlation. The interaction energy of each amino acid belonging to the binding site to the ligand was calculated the using the method of molecular fragmentation with conjugated caps (MFCC). Besides energy, we calculated the distances, types of molecular interactions and atomic groups involved. The theoretical models used were satisfactory and show a more accurate description when the dielectric constant = 20 ? and 80 was used. The results demonstrate that the interaction energy of the system reached convergence at 13.5 A. Within a radius of 13,5A the most important residues were identified. Met49, Met84 and Asp81 perform interactions of hydrogen with the ligant. The Asp79 and Asp75 residues present high energy of attraction. Arg54, Arg85 and Lys 131 perform hydrogen interactions with the ligand, however, appear in BIRD graph having high repulsion energy with the inhibitor. The data also emphasizes the importance of residue Tyr161 and the involvement of the catalytic triad composed by Asp75, His51 and Ser135

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-01-14T18:43:07Z No. of bitstreams: 1 AlbaValeriaSaboiaTeixeiraLopes_DISSERT.pdf: 1168957 bytes, checksum: fc49fda54f1359fb6787d97b3cbad786 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-01-15T17:12:45Z (GMT) No. of bitstreams: 1 AlbaValeriaSaboiaTeixeiraLopes_DISSERT.pdf: 1168957 bytes, checksum: fc49fda54f1359fb6787d97b3cbad786 (MD5) / Made available in DSpace on 2016-01-15T17:12:45Z (GMT). No. of bitstreams: 1 AlbaValeriaSaboiaTeixeiraLopes_DISSERT.pdf: 1168957 bytes, checksum: fc49fda54f1359fb6787d97b3cbad786 (MD5) Previous issue date: 2014-11-27 / Esta disserta??o tem como prop?sito identificar e descrever o fen?meno da representa??o discursiva da v?tima e do r?u no g?nero senten?a judicial. A pesquisa insere-se no ?mbito te?rico geral da lingu?stica textual e, mais especificamente, na an?lise textual dos discursos (ATD), teoria desenvolvida por Jean-Michel Adam ([2008] 2011). A no??o de representa??o discursiva proposta pela ATD constitui um dos aspectos mais importantes da dimens?o sem?ntica do texto e ? complementada nos trabalhos de Grize (1990, 1996) a partir da no??o de esquematiza??o. Nessa perspectiva, o trabalho ? orientado pelos estudos da lingu?stica do texto, com Koch (2012, 2005, 2004), Marcuschi (2012, 2008, 2005), Rodrigues, Passeggi e Silva Neto (2010, 2012, 2014); do g?nero, com Bazerman (2005), Bakhtin (1992); e do discurso jur?dico, com Capez (2012), Pimenta (2007), Louren?o (2013) e Gomes (2014). Metodologicamente, ? uma pesquisa documental, apresentando um car?ter qualitativo, descritivo e orienta-se pelo m?todo do racioc?nio indutivo-dedutivo. O corpus ? constitu?do por uma senten?a judicial, de natureza penal, coletado eletronicamente do s?tio do Tribunal de Justi?a de S?o Paulo ? Poder Judici?rio, em Consulta de Julgados de 1? Grau, com a tem?tica da viol?ncia contra a mulher. Os procedimentos de an?lise utilizaram as categorias sem?nticas da representa??o discursiva, como a referencia??o, a predica??o, a modifica??o e a localiza??o espacial e temporal. Os resultados focalizaram a constru??o da representa??o discursiva dos sujeitos (v?tima e r?u) a partir de PdV de enunciadores distintos, que podem aproximar-se ou distanciar-se de acordo com a orienta??o argumentativa do texto. Assim, diante da import?ncia social do texto forense e, em especial, da senten?a judicial na vida dos cidad?os, foi poss?vel perceber a relev?ncia em desenvolver pesquisas que abordem o estudo da dimens?o sem?ntica do texto, principalmente na constru??o das representa??es dos objetos de discurso / This dissertation aims to identify and describe the phenomenon of discursive representation of victim and defendant in court judgment genre. Researchis part of general theoretical framework of text linguistics and more specifically in textual discourse analysis (ATD) theory developed by Jean-Michel Adam ([2008] 2011). Discursive representation notion proposed by ATD is one of the most important aspects of semantic dimension of the text, being complemented in the work of Grize (1990, 1996) from schematization notion. In this perspective, this work is guided by studies of text linguistics with Koch (2012, 2005, 2004), Marcuschi (2012, 2008, 2005), Rodrigues, Passeggi and Silva Neto (2010, 2012, 2014), with genre Bazerman (2005), Bakhtin (1992) and the juridical discourse with Capez (2012), Pimenta (2007), Louren?o (2013) and Gomes (2013) . Methodologically, is a documentary research, presenting qualitative and descriptive characters and is guided by the inductivedeductive method. Corpus consists of a judicial sentence, criminal, collected electronically from Court of Justice of S?o Paulo - Judiciary website in consultation Judged1st Degree, with the theme of violence against women. Analysis procedures use semantic categories of discursive representation, such as referencing, predication, modification and the spatial and temporal location. Results are focused on the construction of discursive representation of (victim and defendant) from PdV distinct enunciators, which may approach or distance themselves according to argumentative text orientation. Thus, considering social importance of forensic text and, in particular, court judgment in the lives of citizens, it was possible to realize the importance of developing research that addresses the study of text semantic dimension, especially in construction of representations of discourse objects

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-01-27T19:12:32Z No. of bitstreams: 1 FranciscoAmericoMicussi_DISSERT.pdf: 9249981 bytes, checksum: 572c653683e2af16777d794f6d7e3e9b (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-02-02T22:29:41Z (GMT) No. of bitstreams: 1 FranciscoAmericoMicussi_DISSERT.pdf: 9249981 bytes, checksum: 572c653683e2af16777d794f6d7e3e9b (MD5) / Made available in DSpace on 2016-02-02T22:29:41Z (GMT). No. of bitstreams: 1 FranciscoAmericoMicussi_DISSERT.pdf: 9249981 bytes, checksum: 572c653683e2af16777d794f6d7e3e9b (MD5) Previous issue date: 2014-09-19 / A gesta??o ? um per?odo singular na vida da mulher, demandando aten??o especial da fam?lia e dos profissionais de sa?de. No Brasil, o Minist?rio da Sa?de adotou o Cart?o da Gestante para acompanhamento do Pr?-natal, o que n?o tem se mostrado instrumento capaz de contribuir para a melhoria da qualidade dessa assist?ncia, considerando que os registros s?o falhos, dificultando a compreens?o dos mesmos por parte das gestantes. O projeto de interven??o que resultou nesta disserta??o teve por objetivo implantar uma Caderneta da Gestante visando o aprimoramento ao atendimento ? mulher no ciclo grav?dico-puerperal. O local da interven??o foi a Unidade Sa?de da Fam?lia do Campo da Mangueira, no munic?pio de Maca?ba/RN, Brasil. A Caderneta foi adotada como ferramenta tecnol?gica da gest?o do cuidado, de modo inclusivo e participativo, incluindo gestantes e equipe em todas as fases da implanta??o. Foram selecionadas e acompanhadas 09 (nove) gestantes, na faixa et?ria de 19 (dezenove) a 30 (trinta) anos, sendo a m?dia de idade de 24 (vinte e quatro) anos e no per?odo gestacional compreendido de 07 (sete) a 11 (onze) semanas durante abril a julho de 2014. No total foram realizadas 46 (quarenta e seis) consultas, dentre as quais 27 (vinte e sete) pelo m?dico, 19 (dezenove) pela enfermeira, al?m dos atendimentos realizados pelo dentista, imuniza??o e visitas domiciliares. O registro do processo de implanta??o da caderneta constou de anota??es em prontu?rios e relat?rios dos momentos de encontros com gestantes e com equipe de sa?de. Constatou-se que al?m de uma constru??o coletiva, humanizada e interdisciplinar houve a satisfa??o demonstrada pelas gestantes contribuindo dessa maneira para a ades?o ao Pr?-Natal - PN, maior estabelecimento de v?nculos, melhora da autoestima das gestantes e melhoria na qualidade do PN. Considera-se que a implanta??o da Caderneta da Gestante na referida Unidade de Sa?de contribuiu para mudan?as nos modos de fazer a aten??o materno-infantil na Estrat?gia de Sa?de da Fam?lia e pode ser recomendada para implanta??o na rede municipal. / Pregnancy is a unique period in a woman's life, demanding attention from family and health professionals. In Brazil, the Ministry of Health adopted the Pregnant Card to monitor the Prenatal, which has not proven means of contributing to improving the quality of that care, considering that the records are flawed, making the understanding of them more difficult for the pregnant women. The intervention project that resulted in this dissertation sought to deploy a Handbook of the Pregnant aimed at improving the treatment of women in pregnancy and childbirth. The intervention site was the Family Health Unit of the Campo da Mangueira, in the municipality of Maca?ba/RN, Brazil. The Handbook was adopted as a technological tool of management of care, in an inclusive and participatory manner, including pregnant women and staff in all phases of the deployment. Were selected and monitored nine (09) patients, aged between nineteen (19) and thirty (30) years old, with an average age of 24 (twenty four) years and comprised the gestation period of seven (07) to eleven (11) weeks during the period April-July 2014. Altogether were made 46 (fortysix) queries, among which 27 (twenty-seven) by the doctor, nineteen (19) by the nurse in addition to the services performed by the dentist, immunization and home visits. The record of the deployment process of the book consisted of notes in medical records and reports of the moments of encounters with pregnant women and health care team. It was found that in addition to a collective, humanized and interdisciplinary construction, there was the satisfaction demonstrated by pregnant women, thus contributing to adherence to Prenatal - PN, higher establishment of links, improved self-esteem of pregnant women and improving the quality of PN. It is considered that the implementation of the Handbook in the mentioned Health Unit contributed to changes in ways of doing the maternal and childcare in the Family Health Strategy and can be recommended for deployment in the municipality of Maca?ba.