Submitted by Edisangela Bastos (edisangela@ufpa.br) on 2013-11-25T18:01:54Z No. of bitstreams: 2 license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) Tese_PoliticasIntegracaoFronteira.pdf: 9459355 bytes, checksum: ad032125cd27535a0c2d7f739bd7c9dc (MD5) / Approved for entry into archive by Ana Rosa Silva(arosa@ufpa.br) on 2013-11-28T17:06:23Z (GMT) No. of bitstreams: 2 license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) Tese_PoliticasIntegracaoFronteira.pdf: 9459355 bytes, checksum: ad032125cd27535a0c2d7f739bd7c9dc (MD5) / Made available in DSpace on 2013-11-28T17:06:23Z (GMT). No. of bitstreams: 2 license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) Tese_PoliticasIntegracaoFronteira.pdf: 9459355 bytes, checksum: ad032125cd27535a0c2d7f739bd7c9dc (MD5) Previous issue date: 2012 / CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico / As áreas de fronteiras internacionais constituem espaços altamente complexos, marcados pela grande diversidade de agentes étnicos e de identidade plurinacionais. Na Amazônia Sul Ocidental, tem-se uma área geopolítica estratégica de fronteira trinacional composta pelo Acre (Brasil), Madre de Dios (Peru) e Pando (Bolívia). A preocupação com a segurança nacional, da qual emana a criação de um território especial ao longo do limite internacional continental do país, embora legítima, não tem sido acompanhada de uma política pública sistemática que atenda às especificidades regionais, nem do ponto de vista econômico, nem da cidadania fronteiriça. A integração física do Brasil, como questão central do interesse nacional e do combate às atividades ilícitas, atribui às fronteiras novo papel estratégico. Reativam-se, assim, o interesse pelas fronteiras a partir desse duplo processo, tornando as relações transfronteiriças um tema prioritário das relações internacionais. Com efeito, a busca de um novo significado para as interações do Brasil com seus países limítrofes vem impondo o redirecionamento da ação do Estado brasileiro, com reflexos na geopolítica internacional dessa região da América do Sul. O objetivo central deste estudo é analisar as políticas e ações de integração regional, no processo de desenvolvimento, em uma área de fronteira sob a jurisdição trinacional do Brasil, Peru e Bolívia. / International borders are highly complex spaces, characterized by great diversity of ethnicities and multinational identities. In the South western Amazon there is a strategic geopolitical area, formed by the trinational frontier between Acre (Brazil), Madre de Dios (Peru) and Pando (Bolivia). Despite legitimate national security concerns, justifying the creation of a special territory along the international boundary, there is no systematic policy addressing regional specificities, from either an economic or citizenship standpoint. The physical integration of Brazil, as a core issue regarding both the national interest and the fight against illicit activities, attaches a new strategic role to international boundaries. Interest for boundaries is gaining a new momentum out of these issues, making cross-border relations a priority in international relations. Indeed, the search for new meaning to the Brazil’s interactions with its neighboring countries, has been redirecting the action of the Brazilian State, with reflections on South America’s geopolitics. The aim of this study is to analyze regional integration policies and actions in the context of the development process taking place in a trans-frontier area under the trinational jurisdiction of Brazil, Peru and Bolivia. / Las áreas de frontera internacionales se constituyen en espacios altamente complejos, marcados por una gran diversidad de agentes étnicos y de identidades plurinacionales. En la Amazonía sur occidental hay una área geopolítica estratégica de frontera trinacional constituida por Acre (Brasil), Madre de Dios (Perú) y Pando (Bolivia). La preocupación con la seguridad nacional, de donde surge la creación de un territorio especial a lo largo del límite internacional continental del país, aunque legítima, no ha sido acompañada de una política pública sistemática que atienda las especificidades regionales del punto de vista económico e de la ciudadanía fronteriza. La integración física del Brasil, como cuestión central del interés nacional y del combate a las actividades ilícitas, atribuye a las fronteras un nuevo papel estratégico. Se reactiva, así, el interés por las fronteras a partir de ese duplo proceso, volviendo las relaciones transfronterizas, un tema prioritario de las relaciones internacionales. De hecho, la búsqueda de un nuevo significado para las interacciones de Brasil con sus países limítrofes, viene imponiendo el redireccionamiento de la acción del Estado brasileño, con reflejos en la geopolítica internacional de esa región de América del Sur. El objetivo central de este estudio es analizar las políticas y acciones de integración regional, en el proceso de desarrollo en un área de frontera bajo la jurisdicción trinacional del Brasil, Perú y Bolivia.

Il n'est pas nécessaire de rappeler l'importance du thème de la relation entre philosophie et théologie. Cette relation constitue un problème aussi bien théologique que philosophique. Les études qui lui sont consacrées sont légion. La particularité de notre effort réside en ce que nous avons tenté de l'approcher par le biais du problème de la foi. Une confrontation entre la réflexion théologique et la réflexion philosophique sur la foi peut-elle apporter un éclairage pour comprendre la relation entre philosophie et théologie ? Est-il possible d'en dégager quelques pistes et quelques lieux pour une réflexion interdisciplinaire concernant ces deux disciplines ? Telle est la visée du travail. L'intention est aussi de dégager le sens que peut avoir une telle démarche interdisciplinaire dans le contexte de la pensée contemporaine. Dans une première partie, l'exposé de l'état de la question et des déplacements dans la réflexion théologique contemporaine, permet de préciser l'angle d'approche du travail. Au centre des efforts récents, en théologie, concernant la compréhension de la relation entre philosophie et théologie, émerge le problème de la rationalité. C'est aussi celui-ci qui est sous-jacent dans les diverses approches de la théologie contemporaine de la foi. Afin de confronter les résultats obtenus dans la première partie, et avant d'entamer l'étude de la réflexion philosophique sur la foi, il s'est avéré nécessaire d'étudier, pour elle-même, la relation entre philosophie et théologie telle qu'elle est comprise par des théologiens (Balthasar et Rahner) et par des philosophes (Heidegger, Ricœur, Zubiri). C'est ce qui constitue la deuxième partie du travail. L'étude de la réflexion philosophique sur la foi est abordée dans la troisième partie de la thèse. Après un chapitre d'introduction (Duméry, Dondeyne, Heidegger), sont présentées les perspectives métaphysique (Zubiri), herméneutique (Ricœur) et phénoménologique (Welte). L'effort vise à déceler si et comment ces approches entrent en relation avec la théologie, si et comment la réflexion philosophique sur la foi éclaire la relation entre philosophie et théologie. En faisant dialoguer les auteurs entre eux et en dialoguant avec eux, on découvre que la réflexion théologique sur la foi conduit au développement d'une anthropologique générale, et d'autre part, que la réflexion philosophique sur la foi ouvre l'anthropologie à des perspectives théologiques. À partir de là, on est invité à explorer une anthropologie interdisciplinaire de la foi. L'effort pour dire ce qu'est la foi implique celui de dire ce qu'est l'homme et pas seulement ce qu'est l'homme croyant. Cette identité humaine, y compris dans la foi, se révèle comme liberté précaire, comme liberté appelée ou encore comme liberté dans la promesse. Là se découvre le sens profond d'une réflexion interdisciplinaire sur la foi : elle est une approche fondamentale de l'identité humaine. Cette approche s'explicite dans un certain nombre de thèmes fondamentaux, notamment, immanence et transcendance, universalité et particularité, altérité, temporalité, le problème du mal, la question de Dieu. À l'arrière fond de cette réflexion sur la foi dans l'une et l'autre discipline, on trouve le problème de la relation entre foi et vérité, et par ce biais celui de la rationalité. Conçue comme " vérité métaphorique ", comme " vérité réelle ", comme " vérité manifestation " ou encore comme "accès fini à la vérité", la notion de vérité conduit la réflexion à tenter de comprendre la foi comme " foi "livrée" ", comme " foi tragique ", comme " foi fondamentale ". Cependant, ces diverses approches métaphysique, herméneutique et phénoménologique sont insuffisantes en elles-mêmes; elles renvoient les unes aux autres dans une dynamique de complémentarité nécessaire. En dernière instance, aussi bien dans chacune des approches que dans leur ensemble, émerge toujours le thème du "mystère" comme noyau dur de toute réflexion sur la foi. C'est pourquoi, celle-ci ouvre la voie vers l'exploration de ce qu'on pourrait appeler une " rationalité mystique ".

Thyroid hormones, which are secreted by the thyroid gland, are one of the most important halogenated compounds in the body. Thyroid hormones control almost every processes in the body including growth, body temperature, protein synthesis, carbohydrate and fat metabolism, heart rate, and cardiovascular, renal and brain function. Thyroid gland secretes L-thyroxine or 3,3',5,5'-tetraiodothyronine (T4) as a prohormone. While the biologically active hormone 3,3',5-triiodothyronine (T3) is produced by selective phenolic ring deiodination of T4, selective tyrosyl ring deiodination of T4 produces a biologically less active metabolite 3,3',5'-triiodothyronine (rT3). Tyrosyl and phenolic ring deiodination of T3 and rT3, respectively, also produces a biologically inactive metabolite 3,3'-diiodothyronine (3,3'-T2). Regioselective deiodinations of thyroid hormones are catalysed by three isoforms of a selenoenzyme iodothyronine deiodinase (DIO1, DIO2, DIO3). DIO1 can remove iodine from both the tyrosyl and phenolic rings of thyroid hormones, whereas DIO2 and DIO3 are selective towards phenolic and tyrosyl ring, respectively. Although the Figure 1. (A) Deiodination of thyroid hormones by iodothyronine deiodinases (DIOs) (A) and naphthyl-based selenium and/or sulphur compounds (B). mystery behind the origin of regioselectivity of deiodination by DIOs remains unsolved, formation of halogen bonding between selenium in the active site of DIOs and iodine of thyroid hormones has been widely accepted as the mechanism of deiodination. Halogen bonding, a noncovalent interaction between halogen and an electron donor such as nitrogen, oxygen, sulphur, selenium etc., elongates the C-I bond and impart a carbanionic character on the carbon atom that gets protonated after the removal of iodide. Apart from the deiodination, thyroid hormones also undergo decarboxylation, oxidative deamination, sulphate-conjugation to form iodothyronamines, iodothyroaetic acids and sulphated thyroid hormones, respectively. Figure 2. (A) Proposed mechanism of deiodination of thyroid hormones by deiodinase mimics. (B) Halogenation of uracil- and cytosine-containing nucleosides by hypohalous acid (HOX). Recently, naphthyl-based selenium/sulphur-containing compounds, such as compound 1 (Figure 1B), have been reported to mediate the selective tyrosyl ring deiodination of T4 and T3 to form rT3 and 3,3'-T2, respectively. Interestingly, replacement of the selenol moiety in compound 1 with a thiol decreases the activity, whereas replacement of the thiol moiety with another selenol dramatically increases the deiodination activity. Based on the detailed experimental and theoretical investigations, a mechanism involving the Se···I halogen bonding was proposed (Figure 2A). In addition to the halogen bonding between selenium and iodine atom, chalcogen bonding between two nearby chalcogen atoms was also shown to be important for the deiodination activity. Another important class of halogenated compounds in the body are the halogenated nucleosides. Myeloperoxidase and eosinophil peroxidase are heme-containing enzymes, which can convert halide ions (X¯) into a toxic reactive halogen species hypohalous acid (HOX) in presence of hydrogen peroxide (H2O2). Uracil- and cytosine-containing nucleosides are known to undergo halogenation at the 5-position of the nucleobase to form the halogenated nucleosides (Figure 2B). Interestingly, halogenated nucleosides such as 5-halo-2'-deoxyuridine are known to be incorporated in the DNA of dividing cells essentially substituting for thymidine. Incorporation of halogenated nucleosides into the DNA leads to mutagenesis, carcinogenesis and loss of genome integrity. Thymidylate synthase (TSase), the key enzyme involved in the biosynthesis of 2'-deoxythmidine-5'-monophosphate (dTMP) from 2'-deoxyuridine-5'-monophosphate (dUMP), can catalyse the dehalogenation of halogenated nucleotides in presence of external thiols. This thesis consists of five chapters. The first chapter provides a general introduction to halogen bonding, thyroid hormones and halogenated nucleosides. This chapter also briefly describes the halogen bond-mediated biochemical and biomimetic deiodinations of thyroid hormones by iodothyronine deiodinases and naphthyl-based organoselenium compounds. Dehalogenation of halogenated nucleotides by thymidylate synthase and thiol-based small molecules has also been discussed in this chapter. The second chapter of this thesis contains the regioselective deiodination of iodothyronamines (TAMs) by deiodinases mimics. TAMs are the endogenous metabolites produced by the decarboxylation of β-alanine side chain of thyroid hormones (THs). 3,3',5-triiodothyronamine (T3AM) and 3,5-diiodothyronamine (3,5-T2AM) undergoes selective tyrosyl ring deiodination by deiodinase mimics to form 3,3'-diiodothyronamine (3,3'-T2AM) and 3-iodothyronamine (3-T1AM), respectively. Interestingly, when the initial rates of deiodinations of T3 and T3AM were compared, deiodination of T3 was found to be several fold faster than that of T3AM under identical reaction conditions. To understand the ability of the iodine atoms to form Figure 3. (A) HPLC chromatogram of deiodination of T3. (B) Proposed mode of interaction of dimeric T3 and monomeric T3AM with organoselenium compounds. halogen bonding, a model selenolate (MeSe¯) was optimized with the T3 and T3AM. Although both T3 and T3AM forms the expected Se···I halogen bonding with MeSe¯, the strength of halogen bonding was found to be less for T3AM than T3. Furthermore, detailed kinetic and spectroscopic studies indicate that T3 and T3AM exist as dimeric and monomeric species in solution. The dimerization of T3 in solution was shown to have remarkable impact on the activation energy and pre-exponential factor of the deiodination reactions. Single crystal X-Ray crystallography and theoretical calculations indicated that in addition to Se···I halogen bonding, I···I halogen bonding may play an important role in the deodination of thyroid hormones by deiodinase mimics. Furthermore, the presence of heteroatoms such as nitrogen, oxygen and sulphur in the close proximity of one of the selenium atoms of deiodinase mimics was shown to have significant effect on the rate of deiodination reactions. The third chapter of the thesis focusses on the conformational polymorphism and conformation-dependent halogen bonding of L-thyroxine. Synthetic version of L-thyroxine (T4) is a life-saver for millions of people who are suffering from hypothyroidism, a thyroidal disorder recognised by low levels of T4 and elevated levels of TSH in blood plasma. Synthetic version of L-thyroxine is available in the Figure 4. Ball and stick model of the single crystal X-Ray structure of the conformational polymorphs of L-thyroxine. Form I and Form II was exclusively crystallized from methanol and acetonitrile, respectively. Water molecules are omitted for clarity. market with various brand names. However, adverse effects have been observed in the patients when they switch their brand of thyroxine. Based on these observations, the American Thyroid Association (ATA), the Endocrine Society (TES), and the American Association of Clinical Endocrinologists (AACE) declared that the different brands of T4 are not bioequivalent, thus leading to differences in the bioavailability of the drug. We have shown that the commercially available thyroxine exists in at least two stable forms (Form I and Form II) with different three-dimensional structures (Figure 4). These two forms exhibit different intermolecular interactions in crystal packing, spectral behaviours, thermal stabilities, optical activity and very interestingly, different solubility in acidic and basic pH. At pH 4, solubility of Form I is about 42% and 45% greater than that of Form II and bulk T4, respectively, whereas at pH 9, the solubility of Form II is about 38% and 42% higher than that of Form I and bulk T4, respectively. As T4 is a narrow therapeutic index drug, these differences in solubility may have remarkable impact on the bioavailability of the drug. In addition to this, we have shown that the ability of the iodine atoms in the C-I bonds to form halogen bond with donor atoms can be altered by changing the relative orientation of tyrosyl and phenolic rings in T4. In the fourth chapter, the three-dimensional structures and conformations of thyroid hormones (THs) and iodothyronamines (TAMs) are discussed. TAMs, the endogenous decarboxylated metabolites of THs, exhibit different binding affinities to the transport proteins and iodothyronine deiodinases (DIOs) compared to the THs. Figure 5. Change in the structure and conformations of thyroid hormones and iodothyronamines with the decarboxylation of amino acid side chain and deiodination of phenolic and tyrosyl ring. Furthermore, the substrate specificities of DIOs have been found to be dependent on the position of iodine atoms on the phenolic and tyrosyl ring of TAMs and THs. Single crystal X-ray structures of TAMs indicate that decarboxylation of amino acid side chain of THs induces significant changes in the structure and conformation. Furthermore, the positional isomers of THs and TAMs exhibit remarkably different conformations, which may have significant effect on the binding of these metabolites to the active site of DIOs. In addition to the structure and conformations, different categories of the intermolecular halogen···halogen (X···X) interactions in the crystal packing of THs and TAMs have also been discussed. Natural bond orbital (NBO) analysis have been done on the halogen-bonded geometries to understand the electronic nature of these interactions. In the fifth chapter, the dehalogenation of halogenated nucleosides and nucleobases by naphthyl-based sulphur/selenium compounds is discussed. Purine and pyrimidine nucleosides are halogenated at various positions of the aromatic ring by different peroxidases such as myeloperoxidase and eosinophil peroxidase present in the white blood cells. Incorporation of the halogenated nucleosides into the DNA of replicating cells leads to DNA-strand breaks, mutagenesis, carcinogenesis and loss of Figure 6. (A) Dehalogenation of halogenated nucleosides. Effect of base-pairing wih adenine and guanine on the deiodination of IU (B) and debromination of BrU (C) by compound 2. genome integrity. We have shown that the naphthalene-based organoselenium compounds such as compound 2 can mediate the dehalogenation of 5-iodo-2'-deoxyuridine (5-IdUd) and 5-bromo-2'-deoxyuridine (5-BrdUd) to produce 2'-deoxyuridine (dUd) (Figure 6A). The deiodination of 5-IdUd was found to be faster than the debromination of 5-BrdUd by compound 2. The mechanism of dehalogenation of halogenated nucleosides by compound 2 was found to be dependent on the nature of halogen. While the deiodination of 5-IdUd by compound 2 follow halogen bond-mediated pathway like thyroid hormones, debromination of 5-BrdUd follow a Michael addition-elimination pathway. Similar results were obtained when 5-iodo-2'-deoxycytidine (5-IdCd) or 5-bromo-2'-deoxycytidine (5-BrdCd) was used as substrate for dehalogenation reaction. Base-pairing of 5-iodouracil (IU) and 5-bromouracil (5-BrU) with adenine and guanine has a significant effect on the rate of dehalogenations of IU and BrU by compound 2 (Figure 6B and 6C).

Made available in DSpace on 2014-12-17T14:33:10Z (GMT). No. of bitstreams: 1 MarcioLFR_DISSERT.pdf: 949735 bytes, checksum: 7b0d7914f06ce721cd7df5864b67525c (MD5) Previous issue date: 2014-02-11 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / When scientists study methods, theory and standards in an inseparable form, he is facing a paradigm. Throughout the development of a determined science, paradigms can change by changing the methods, objective and standards of research. Fisheries science is changing the paradigm moving from the paradigm of maximization in the use of resources, quantified by the index of the catch, which was influenced by evolutionary concepts such as Optimal Foraging Theory, to the sustainability paradigm that seeks its foundation in the fishery ecosystem perspective. The goal of this study was to review methods, theory and the history of ecosystem indexes of fishery science that attempts to determine sustainability of fishery resources from the data capture. Ecosystems indexes by themselves may not be useful to measure the sustainability of fishing because they focus only on the environmental or ecological side of the sustainability tripod. Probably to measure the sustainability of fishing these indexes should include in the future the Payments for Ecosystem Services and Social Resilience. Thus the methods and theories are in constantly changing within science to meet the most current paradigm / Quando o cientista enxerga de forma insepar?vel os m?todos, a teoria e as normas ele est? diante de um paradigma. Ao longo do tempo o desenvolvimento de uma determinada ci?ncia o paradigma pode mudar alterando os m?todos, os objetivos e as normas da pesquisa com o passar dos anos. Ci?ncia Pesqueira transitou de paradigma da maximiza??o na utiliza??o dos recursos, quantificada pelo ?ndice da captura, que foi influenciado por conceitos evolutivos como a Teoria do Forrageamento ?timo para um paradigma da sustentabilidade que busca seu alicerce na perspectiva ecossist?mica da pesca. O objetivo desse trabalho foi realizar uma revis?o que aborda m?todos, teoria e o hist?rico dos ?ndices ecossist?micos da ci?ncia pesqueira que tentam determinar a sustentabilidade dos recursos pesqueiros a partir dos dados de captura. Os ?ndices ecossist?micos talvez n?o consiga mensurar a sustentabilidade da pesca por si s?, porque eles abordam apenas o lado ambiental ou ecol?gico do trip? da sustentabilidade. Provavelmente para se mensurar a sustentabilidade da pesca esses ?ndices devem se juntar no futuro com os Pagamentos por Servi?os Ecossist?micos e a Resili?ncia Social. Assim os m?todos e as teorias se agregam e se reformulam constantemente dentro dessa ci?ncia para atender o paradigma mais atual

L'objectif de ce mémoire est d'analyser les différents éléments humoristiques présents dans le roman Dios se lia ido de Javier Garcia Sánchez. Cette œuvre allie la tristesse et l'humour dans des réflexions sur la vie, la solitude, le sexe et le jeu d'échecs dans la vie quotidienne d'un homme solitaire dans la quarantaine, qui devient l'univers exclusif du lecteur. On explore et critique l'évolution de la société espagnole contemporaine qui commence avec la transition démocratique à l'aide, entre autres, du grotesque, des jeux de mots, de la parodie et de l'ironie. On aborde également d'autres thèmes sociaux du point de vue d'un homme ordinaire avec ses préjugés et ses fausses interprétations. Dans ce roman, l'humour possède une fonction récréative mais il mène également à une réflexion sur les valeurs et la vie à une époque de scepticisme et de décadence.

Ces travaux sont du domaine de génie systèmes industriels et l'ingénierie de l'innovation. Ils se sont déroulés dans l'industrie de services financiers au sein du groupe de banque-assurance Groupama. Les services représentent 64% de PIB mondial. Le secteur employait en 2007 en France près de 20 millions de personnes contre 5 millions pour l'industrie. Pourtant la recherche sur les processus d'innovation présente un déséquilibre avec un article scientifique NSD (new service development) pour quatre NPD (new product development). L'objectif de ces travaux est de proposer une méthode de pilotage des projets d'innovation dans les services. Pour formaliser le pilotage d'innovation dans les services tout en préservant la zone de liberté nécessaire à l'innovation, nous sommes basés sur un formalisme de type NPD pour définir un processus NSD qui respecte la flexibilité spécifique de l'innovation dans les services. Le coeur de notre hypothèse a été d'identifier des invariants de processus NSD. Nous proposons six classes d'invariants : les OICs (Objets Intermédiaires de Conception), les ressources, les compétences, les tâches, les indicateurs et les méthodes. Leurs interactions sont rendues dans un Diagramme de Classes UML. Un projet peut être décrit comme une « somme » d'OIC eux-mêmes résultat de l'agencement des 5 autres invariants. Ces six classes d'invariants ont été validées sur projets de Groupama. Elles permettent de décrire, suivre, capitaliser, réutiliser des savoirs acquis sur des projets antérieurs et de manager les projets innovants. Nous proposons aussi un processus de pilotage des projets NSD, formalisé par un Diagramme d'Ordonnancement des Phases sous MEGA / The present thesis is about the field of system engineering and innovation engineering. It took place in the financial industry within the group of banking insurance Groupama. Services represent 64% of world's GDP (Gross Domestic Product). This branch employed in 2007 in France about 20 million people against 5 million for industry. Still the research on the innovation processes presents a gap with only one NSD (new services development) article against four NPD (new products development). The aim of this work is to propose a method for management of innovation projects in the services branch. To formalize the management of innovation projects for the services, while preserving the space required for innovation, we use a NPD's type formalism in order to define a NSD process while respecting the specific flexibility of the innovation in the services branch. The center of our hypothesis was to identify invariants within the NSD process. We propose six classes of invariants: IDOs (Intermediate Design Objects), the resources, the skills, the tasks, the indicators and the methods. Theirs interactions are shown in a UML Diagram of Classes. A project may be represented as an "addition" of IDOs, where they are the result of 5 other invariants arrangements. These six classes of invariants were validated on Groupama projects. They are relevant to describe, monitoring, capitalize, re-use of the knowledge acquired on previous projects and to manage innovative projects as well. We also propose a process of piloting of the NSD projects, formalized by a Diagram of Phases Sequencing of MEGA

Beginning in the 16th century, the Isthmus of Panama was identified as a region of strategic importance. Although mountainous and prone to adverse weather, it provided the most direct route between the Atlantic and Pacific oceans. During this period the Isthmus served as the primary route for the shipments of silver and gold extracted from the mines of Peru. The bullion was transported via coastal armadas from Peru to Panamá la Vieja, where it was loaded onto pack mules and hauled across the Isthmus to Nombre de Dios until 1597, and after that to Portobelo. Once the bullion arrived at the Caribbean port cities it was transferred to the ships of the Armada de la Guardia de la Carrera de Indias and shipped across the Atlantic to the royal coffers of Spain. Because of the Isthmus’s role in the transportation of valuable commodities, it quickly became a region prone to attacks by pirates and privateers looking to profit from the plunder of Spanish assets. Thus the Spanish crown began a campaign to defend the Isthmus early on and repeatedly adapted its defensive strategy in order to meet the ever-changing tactics of the pirates and privateers. This thesis investigates the history of the Isthmus of Panama and the ways in which Spain defended this strategically significant locale during the 16th century. It incorporates an historical analysis of the tactics planned, ordered, and executed by the crown; an overview of the most relevant structural remains of the fortifications built during this period; and a synopsis of previous archaeological investigations, as well as the prospects of future archaeological research. The thesis begins with a brief history of the three main cities located on the Isthmus as well as a general description of the geography and climate in order to better explain the challenges faced by the inhabitants, soldiers, and attackers in this region. It then discusses the strategic importance of the Isthmus as it was perceived in the 16th century. Since defense would not have been necessary had it not been for the presence of pirates and privateers, the history of attacks on the Isthmus is discussed, and a general overview of piracy in the Spanish Main during the period under analysis is presented. Lastly, the archaeological work previously undertaken in the region is examined and summarized, and recommendations for further research are provided in an effort to provide a basis for future study of the ships and infrastructure used during this era for the defense of the Isthmus of Panama.

This article addresses the question of whether extreme weather events should form the basis for individuals or even the States, may be exempted from complying with its legal obligations.The old, but still very viable institution of force majeure can empower both companies and nations to absolve themselves of their responsibilities and duties. However, in a world where human-induced climate change is proven, could we say that such disasters are truly«natural»? Does it make sense, from a legal and factual matter, that they continue to allow the parties to be exempt from liability when modern science has shown that in all probability people, not some enigmatic power, have caused most universally of the problems that hold us harmless looking?Force majeure is based on the idea that the «man» somehow is separate from «nature». This article challenges this idea and argues that, in many cases, no longer makes sense to apply the institution of force majeure. At least, judges should be very careful in doing so for reasons of public policy and allocation of risks. In addition, the contracting parties must have enough caution to claim that they may be able to exempt themselves from future liability clauses appealing «force majeure». / Este artículo aborda la pregunta sobre si los eventos de clima extremo deben servir de base para que los particulares o, incluso los Estados, puedan eximirse de cumplir con sus obligaciones legales.La antigua, pero aún muy viable, institución de la fuerza mayor, puede facultar tanto a las empresas como a los Estados-Nación a eximirse de sus responsabilidades y deberes. Sin embargo, en un mundo donde el cambio climático antropogénico está probado,¿podríamos decir que tales desastres son verdaderamente «naturales»? ¿Acaso tiene sentido, desde un punto de vista legal y fáctico, que se les siga permitiendo a las partes eximirse de responsabilidad legal cuando la ciencia moderna ha demostrado con toda probabilidad que, las personas -no algún misterioso poder universal- han ocasionado la mayoría de los problemas por los que buscamos eximirnos de responsabilidad?La fuerza mayor se basa en la idea de que el «hombre», de alguna manera, se encuentra separado de la «naturaleza». Este artículo cuestiona esta idea y argumenta que, en muchos casos, ya no tiene sentido aplicar la institución de la fuerza mayor. Al menos, los jueces deben ser muy cuidadosos al hacerlo por razones de política pública y asignación de riesgos, así como las partes contratantes deben tener la suficiente precaución al pensar o pretender que pueden ser capaces de eximirse de responsabilidad futura invocando cláusulas de «fuerza mayor».

Cerrillos is an Early to Middle Paracas civic-ceremonial site located in the upper Ica Valley of Perú. The site is known for its finely plastered adobe architecture, beautifully decorated ceramics, and complex textiles, many of which are decorated with camelid hair. Cerrillos was located in a strategically important place where the mountains meet the coastal desert and the Ica River bends south, a likely intersection in a road system that connected Cerrillos to contemporary sites in the Paracas region and beyond. This paper focuses on several early textiles, ceramics, and other artifacts, including ceramic palettes used for gold working and wooden earspools, that suggest that Cerrillos was involved in a cultural phenomenon or interaction sphere that linked sites as far away was Chavín de Huántar through the interchange of goods, beliefs, and practices. The paper presents a complete description of the textiles excavated at Cerrillos between 1999 and 2002, focusing on two fabric fragments with images of the Staff Deity and one with an abstract Chavín-like design. The ceramics discussed in the text demonstrate the wide variety of styles found at Cerrillos, including some that resemble the Janabarriu of Chavín de Huántar and several others that are either not Paracas or an Early Paracas style that has never been previously described. / Cerrillos es un sitio cívico-ceremonial con ocupación entre las épocas Paracas Temprano y Medio, localizado en el valle alto de Ica, Perú. Es conocido por su arquitectura de adobe enlucida de manera fina, cerámica bellamente decorada y textiles complejos, muchos de ellos decorados con fibra de camélido. Estuvo localizado en un lugar de importancia estratégica, donde las montañas se encuentran con el desierto costero y el río Ica gira hacia el sur, una probable intersección en un sistema de caminos que lo conectaba con sitios contemporáneos en la región de Paracas y más allá. Este artículo se enfoca en diversos textiles, cerámica y otros artefactos tempranos, entre ellos paletas de cerámica usadas para trabajar el oro y aretes en forma de argollas de madera, lo que sugiere que este complejo estaba involucrado en un fenómeno cultural o esfera de interacción que vinculaba sitios tan lejanos como Chavín de Huántar mediante el intercambio de bienes, creencias y prácticas. Este artículo presenta una completa descripción de los textiles excavados en Cerrillos entre 1999 y 2002, y se enfoca en dos fragmentos textiles, uno con imágenes del Dios de las Varas y el otro con un diseño abstracto parecido al chavín. La cerámica tratada en el texto demuestra la amplia variedad de estilos encontrados, entre ellos algunos que se parecen al Janabarriu de Chavín de Huántar y varios otros que no corresponden al estilo Paracas o que semejan un estilo Paracas Temprano que nunca antes ha sido descrito.

Made available in DSpace on 2014-12-17T14:08:54Z (GMT). No. of bitstreams: 1 HumbertoSC_DISSERT.pdf: 7792135 bytes, checksum: 5204c60825f60e9f74c5f24e46e8aa4e (MD5) Previous issue date: 2013-07-29 / Nearly 3 x 1011 m3 of medium and light oils will remain in reservoirs worldwide after conventional recovery methods have been exhausted and much of this volume would be recovered by Enhanced Oil Recovery (EOR) methods. The in-situ combustion (ISC) is an EOR method in which an oxygen-containing gas is injected into a reservoir where it reacts with the crude oil to create a high-temperature combustion front that is propagated through the reservoir. The High Pressure Air Injection (HPAI) method is a particular denomination of the air injection process applied in light oil reservoirs, for which the combustion reactions are dominant between 150 and 300?C and the generation of flue gas is the main factor to the oil displacement. A simulation model of a homogeneous reservoir was built to study, which was initially undergone to primary production, for 3 years, next by a waterflooding process for 21 more years. At this point, with the mature condition established into the reservoir, three variations of this model were selected, according to the recovery factors (RF) reached, for study the in-situ combustion (HPAI) technique. Next to this, a sensitivity analysis on the RF of characteristic operational parameters of the method was carried out: air injection rate per well, oxygen concentration into the injected gas, patterns of air injection and wells perforations configuration. This analysis, for 10 more years of production time, was performed with assistance of the central composite design. The reservoir behavior and the impacts of chemical reactions parameters and of reservoir particularities on the RF were also evaluated. An economic analysis and a study to maximize the RF of the process were also carried out. The simulation runs were performed in the simulator of thermal processes in reservoirs STARS (Steam, Thermal, and Advanced Processes Reservoir Simulator) from CMG (Computer Modelling Group). The results showed the incremental RF were small and the net present value (NPV) is affected by high initial investments to compress the air. It was noticed that the adoption of high oxygen concentration into the injected gas and of the five spot pattern tends to improve the RF, and the wells perforations configuration has more influence with the increase of the oil thickness. Simulated cases relating to the reservoir particularities showed that smaller residual oil saturations to gas lead to greater RF and the presence of heterogeneities results in important variations on the RF and on the production curves / Aproximadamente 3 x 1011 m3 de ?leos m?dios e leves restar?o nos reservat?rios ao redor do mundo ap?s a aplica??o dos m?todos convencionais de recupera??o e grande parte desse volume seria recuper?vel com o uso de m?todos especiais. A combust?o in-situ (CIS) ? um m?todo de recupera??o avan?ada de petr?leo no qual um g?s que cont?m oxig?nio ? injetado no reservat?rio onde reage com o ?leo cru para criar uma frente de combust?o de alta temperatura que se propaga pelo reservat?rio. O m?todo HPAI (High Pressure Air Injection) ? uma denomina??o particular do processo de inje??o de ar aplicado em reservat?rios de ?leos leves, onde as rea??es de combust?o s?o dominantes entre 150 e 300?C e a gera??o de flue gas ? o principal fator de deslocamento do ?leo. Um modelo de simula??o de fluxo de um reservat?rio homog?neo foi constru?do para o estudo, o qual foi inicialmente submetido ? produ??o prim?ria, por 3 anos, e em seguida, ao processo de inje??o de ?gua por mais 21 anos. Nesse ponto, com a condi??o madura estabelecida no reservat?rio, foram selecionadas tr?s varia??es desse modelo, de acordo com o fator de recupera??o (FR) obtido, para o estudo da t?cnica de combust?o in-situ (HPAI). Em seguida realizou-se uma an?lise de sensibilidade sobre o FR de par?metros operacionais pr?prios do m?todo: vaz?o de inje??o de ar por po?o, concentra??o de oxig?nio no g?s injetado, esquema de inje??o de ar e configura??o dos canhoneados dos po?os. Essa an?lise, para um per?odo adicional de at? 10 anos produ??o, foi efetuada com o aux?lio da t?cnica de planejamento composto central. O comportamento do reservat?rio e os impactos de par?metros envolvendo as rea??es qu?micas e de particularidades de reservat?rio sobre o FR tamb?m foram avaliados. Adicionalmente foram elaborados uma an?lise econ?mica e um estudo de maximiza??o do FR do processo. As simula??es foram realizadas com o simulador de processos t?rmicos em reservat?rios STARS (Steam, Thermal and Advanced Process Reservoir Simulation) da CMG (Computer Modelling Group). Os resultados mostraram que os FR incrementais foram baixos e que o valor presente l?quido (VPL) ? impactado negativamente pelos elevados investimentos iniciais para compress?o do ar. Observou-se que a ado??o de maiores concentra??es de oxig?nio no g?s injetado e do esquema de inje??o de ar tipo five spot tende a favorecer o FR, e que a configura??o dos canhoneados dos po?os apresenta influ?ncia crescente com o aumento da espessura porosa com ?leo do reservat?rio. Casos simulados referentes ?s particularidades de reservat?rio indicaram que menores satura??es residuais de ?leo ao g?s levam a FR maiores e que a exist?ncia de heterogeneidades resulta em varia??es consider?veis nos FR e nas curvas de produ??o