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121	Surf and turf, builder’s mug och Jaffa cakes : Översättningsstrategier vid svensk undertextning av kulturspecifika referenser i anglofona matlagningsprogram / Surf and Tur, Builder's Mug and Jaffa Cakes : Transwlation Strategies in Swedish of Culture Specific References in Anglophone Cooking Shows Hagander, Sara January 2016 (has links) Mat, språk och kultur är tätt sammanlänkade, och i matlagningsprogram förekommer en rad olika sorters kulturspecifika referenser. Kulturspecifika referenser definieras som ”any reference to a cultural entity which, due to its distance from the target culture, is characterized by a sufficient degree of opacity for the target reader to constitute a problem” (Mailhac i Ranzato 2015:54) och kan vara sådant t.ex. som måttenheter (pint), märken (Tabasco) och maträtter (surf and turf). Denna undersöknings fokus är översättningen av kulturspecifika referenser i matlagningsprogram, och eftersom merparten av de matlagningsprogram som översätts för svensk tv är på engelska består denna studies material av 21 engelskspråkiga matlagningsprogram och deras svenska översättningar. De matlagningsprogram som undersökts är Det goda livet, Jamie Olivers smarta rätter, David Roccos ljuva matresa – Italien, Kitchen Hero och Hela England bakar. Genom att att konstruera en korpus och analysera de kulturspecifika referenserna har normerna för översättningsstrategier gällande kulturspecifika referenser i matlagningsprogram kartlagts, och jämförts med resultaten från Pedersens välkända undersökning av primetime-TV (2011). Resultaten kategoriserades sedan enligt Pedersens taxonomi. Resultaten visade att normerna för matlagningsprogram liknade dem för primetime-TV, trots att det fanns ett par domänspecifika skillnader. Eftersom språk formar hur vi ser världen är det intressant att se hur kulturspecifika referenser översätts från en kultur till en annan, eftersom det formar hur den kulturen ses och värderas, eller åtminstone dess matkultur. / Food, language and culture are closely linked and cooking shows are peppered with culturally specific references. Culturally specific references are defined as “any reference to a cultural entity which, due to its distance from the target culture, is characterized by a sufficient degree of opacity for the target reader to constitute a problem” (Mailhac in Ranzato 2015:54) and can be things such as measurements (pints), brands (Tabasco), and dishes (surf and turf) to name a few. This study focuses on the translation of culture specific references in cooking shows. Since most of the cooking shows translated into Swedish are in English, the material for this study consists of 21 cooking shows in English and their Swedish translations. This study will look at the shows 3 good things, Save with Jamie, David Rocco’s Dolce Vita, Kitchen Hero and The Great British Bake off. By constructing a corpus and analyzing the culturally specific references, the norms regarding translation strategies for the translation of culturally specific references in cooking shows have been mapped out, and compared to the results of a well known study on primetime TV by Pedersen (2011). These were categorized in accordance with Pedersen’s taxonomy (2011:76). The results showed that the norms were very similar to those of primetime TV, with the exception of some domain-specific norms. Language influences how we see the world. Thus, the way culturally specific references are translated from one culture into another is important because it affects how cultures are viewed and interpreted, at least within the food community. Norm subtitling culture specific references ECR translation strategy cooking show 3 good things Save with Jamie David Rocco’s Dolce Vita Kitchen Hero Great British Bake off English to Swedish Norm undertextning kulturspecifik referens ECR översättningsstrategi matlagningsprogram Det goda livet Jamies smarta rätter David Roccos ljuva matresa – Italien Kitchen Hero Hela England bakar engelska-svenska General Language Studies and Linguistics
122	Kompozitní stomatologické biomateriály - struktura, analýza a vlastnosti / Composite Dental Biomaterials - Structure, Analysis and Properties Matoušek, Aleš January 2012 (has links) The aim of this work is to define relations between grain size and bioaktivity of oxide ceramics, specifically ZrO2, Al2O3 and HA. Ceramic materials with grain size from 100 nm up to 10 m, with various surface roughness, were tested for its bioactivity. Ceramography analysis was performed for all tested materials to precisely describe microstructures. Biological properties of the ceramic materials were tested via dilation tests directly in-vitro and by in-vitro extraction. Three cell culturing lines: osteoblast MG63, fibroblast L929, and epithelioid HeLa, were used for our testing. An influence of the grain size on the biological response was only found for the ceramic materials which had been thermally etched. The thermally etched nanocrystalline samples had larger areas covered by cells than ceramics with coarse grain microstructure. Biological tests on layered composites Al2O3×ZrO2 showed the cell selection determined by the type of material, where ZrO2 surfaces were preferably covered. Improved biological response of nanocrystalline ZrO2 was demonstrated on ceramic ZrO2, Al2O3 and SiO2 substrates with nanocrystalline coating of ZrO2. In this work a novel technological process for the formation of defect-free coatings was developed. Sintered coatings were tested using in-vitro technique with cell line HeLa, L929 and MG63 for up to 72 hours. The results of the biological tests of nanocrystalline coatings were consistent with results from the bulk nanocrystalline thermally etched ZrO2 ceramics.
123	Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling Kickstein, E., Krauss, S., Thornhill, P., Rutschow, D., Zeller, R., Sharkey, J., Williamson, Ritchie, Fuchs, M., Kohler, A., Glossmann, H., Schneider, R., Sutherland, C., Schweiger, S. January 2010 (has links) No / Hyperphosphorylated tau plays an important role in the formation of neurofibrillary tangles in brains of patients with Alzheimer's disease (AD) and related tauopathies and is a crucial factor in the pathogenesis of these disorders. Though diverse kinases have been implicated in tau phosphorylation, protein phosphatase 2A (PP2A) seems to be the major tau phosphatase. Using murine primary neurons from wild-type and human tau transgenic mice, we show that the antidiabetic drug metformin induces PP2A activity and reduces tau phosphorylation at PP2A-dependent epitopes in vitro and in vivo. This tau dephosphorylating potency can be blocked entirely by the PP2A inhibitors okadaic acid and fostriecin, confirming that PP2A is an important mediator of the observed effects. Surprisingly, metformin effects on PP2A activity and tau phosphorylation seem to be independent of AMPK activation, because in our experiments (i) metformin induces PP2A activity before and at lower levels than AMPK activity and (ii) the AMPK activator AICAR does not influence the phosphorylation of tau at the sites analyzed. Affinity chromatography and immunoprecipitation experiments together with PP2A activity assays indicate that metformin interferes with the association of the catalytic subunit of PP2A (PP2Ac) to the so-called MID1-alpha4 protein complex, which regulates the degradation of PP2Ac and thereby influences PP2A activity. In summary, our data suggest a potential beneficial role of biguanides such as metformin in the prophylaxis and/or therapy of AD. Adenylate Kinase Metabolism Alzheimer Disease Pathology Physiopathology Animals Cells Cultured Enzyme Inhibitors Pharmacology Epitopes HeLa cells Humans Hypoglycemic agents Metformin Mice Transgenic Multiprotein complexes Neurofibrillary Tangles Neurons Cytology Okadaic acid Phosphorylation Protein Phosphatase 2 Proteins Signal Transduction Drug effects TOR Serine-Threonine Kinases Tau Proteins REF 2014
124	Injectable formulations forming an implant in situ as vehicle of silica microparticles embedding superparamagnetic iron oxide nanoparticles for the local, magnetically mediated hyperthermia treatment of solid tumors Le Renard, Pol-Edern 06 September 2011 (has links) (PDF) Cette thèse présente les travaux de développement de formulations injectables capables de se solidifier in situ, formant ainsi un implant piégeant des microparticules magnétiques en vue du traitement de tumeurs par induction magnétique d'une hyperthermie locale modérée. Nous exposons tout d'abord le contexte physique, biologique et clinique de l'hyperthermie comme traitement anticancéreux, particulièrement des modalités électromagnétiques. Les performances in vitro et in vivo des matériaux et formulations sont alors présentées. L'objet du chapitre suivant est la caractérisation des propriétés physicochimiques, magnétiques, et chauffantes, dans un champ magnétique alternatif (115 kHz, 9 - 12 mT), des microparticules de silice renfermant des nanoparticules d'oxyde de fer superparamagnétiques (SPIONs) et de deux de leurs formulations: un hydrogel d'alginate de sodium et un organogel de poly(éthylène-co-alcool vinylique) dans le diméthylsulfoxide. Finalement, nous présentons le potentiel thérapeutique de 20 minutes d'hyperthermie locale induite après injection de l'organogel superparamagnétique dans un modèle murin sous-cutané de tumeurs nécrosantes de colocarcinome humain. hyperthermie hyperthermie locale induction magnétique champs magnétiques alternatifs implants injectables solidification in situ implant in-situ hydrogels alginate poloxamer chitosan organogel cellulose acétate poly(éthylène-co-alcool vinylique) PMMA diméthylsulfoxide HELA microparticules de silice microparticules nano-composite SPION tumeurs solides injection intratumorale colocarcinome cancer adjuvant thérapie adjuvante chauffage par pertes relaxation de Néel relaxation de Brown SQUID specific absorption rate specific loss power ceramiques liposomes réponse immunitaire chaperonnes moléculaires heat shock protein cibles moleculaires de l'hyperthermie
125	Micro RNA-Mediated regulation of the full-length and truncated isoforms of human neurotrophic tyrosine kinase receptor type 3 (NTRK 3) Guidi, Mònica 13 January 2009 (has links) Neurotrophins and their receptors are key molecules in the development of thenervous system. Neurotrophin-3 binds preferentially to its high-affinity receptorNTRK3, which exists in two major isoforms in humans, the full-length kinaseactiveform (150 kDa) and a truncated non-catalytic form (50 kDa). The twovariants show different 3'UTR regions, indicating that they might be differentiallyregulated at the post-transcriptional level. In this work we explore howmicroRNAs take part in the regulation of full-length and truncated NTRK3,demonstrating that the two isoforms are targeted by different sets of microRNAs.We analyze the physiological consequences of the overexpression of some of theregulating microRNAs in human neuroblastoma cells. Finally, we providepreliminary evidence for a possible involvement of miR-124 - a microRNA with noputative target site in either NTRK3 isoform - in the control of the alternativespicing of NTRK3 through the downregulation of the splicing repressor PTBP1. / Las neurotrofinas y sus receptores constituyen una familia de factores crucialespara el desarrollo del sistema nervioso. La neurotrofina 3 ejerce su funciónprincipalmente a través de una unión de gran afinidad al receptor NTRK3, del cualse conocen dos isoformas principales, una larga de 150KDa con actividad de tipotirosina kinasa y una truncada de 50KDa sin dicha actividad. Estas dos isoformasno comparten la misma región 3'UTR, lo que sugiere la existencia de unaregulación postranscripcional diferente. En el presente trabajo se ha exploradocomo los microRNAs intervienen en la regulación de NTRK3, demostrando que lasdos isoformas son reguladas por diferentes miRNAs. Se han analizado lasconsecuencias fisiológicas de la sobrexpresión de dichos microRNAs utilizandocélulas de neuroblastoma. Finalmente, se ha estudiado la posible implicación delmicroRNA miR-124 en el control del splicing alternativo de NTRK3 a través de laregulación de represor de splicing PTBP1. RISC complex retinoic acid renilla luciferase real-time quantitative PCR PTBP1 pri-miRNA pre-miRNA post-transcriptional regulation piRNA PicTar pGL4.13 PCR P-body p75NTR overexpression NTRK3 NTRK2 NTRK1 non-coding RNAs NGF neurotrophin neurotrophic signaling neuronal differentiation neurodevelopment neuroblastoma nervous system mRNA miRNA target prediction miRNA profiling miRNA mimic miRNA microarray miRNA inhibitor miRanda microRNA microarray luciferase assay Ingenuity Pathway Analysis (IPA) heLa cells gene silencing gene regulation full-length isoform (FL-NTRK3) firefly luciferase ERK disease dicer cancer development BDNF argonaute alternative splicing 3'UTR RNAhybrid RT-PCR SH-SY5Y cells siRNA standard error synaptic plasticity target validation TargetScan transfection translational repression TrkA TrkB TrkC truncated isoform (TR-NTRK3) tyrosine kinase (TK) western blot 575 61
126	Hur användardata & andra arbetssätt nyttjas för att nå hög kundtillfredsställelse / How user data & other work methods are utilized to attain high customer satisfaction KALZÉN, EMMA, SÖRENSEN, JULIA January 2020 (has links) Att integrera insamling och analysering av användardata inom produktutveckling förekommer hos företag inom alla branscher över hela världen. Användardata kan ge ett företag information om användare och den informationen kan i sin tur utnyttjas för att utveckla befintliga och nya produkter. Syftet med studien är att undersöka hur användardata och andra arbetssätt i kombination kan identifiera och tillfredsställa kundbehov under utveckling av webbplatser och appar. För att besvara frågeställningen byggdes en teoretisk referensram från en vetenskaplig litteraturstudie. En stor del av litteraturstudien består av Kano modellen för att förklara sambandet mellan olika kundbehov och kundtillfredsställelse. Vidare presenteras vanligt förekommande användardata och andra arbetssätt. Sedan genomfördes en kvalitativstudie hos fyra företag som arbetar med produktutveckling av appar och/eller webbplatser. Den kvalitativa studien bestod av semi-strukturerade intervjuer. Resultaten från den kvalitativa studien analyserades sedan och jämfördes mot den teoretiska referensramen. Efter analys och diskussion av resultaten visar studien att en kombination av användardata och andra arbetssätt är fördelaktigt i en produktutvecklingsprocess för att uppnå hög kundtillfredsställelse. Vidare upptäcker studien svårigheten i att mäta kundtillfredsställelse då användares behov ständigt förändras samt för att tillfredsställelse oftast mäts på specifika produktfunktioner, inte produkten i sin helhet. / Integrating collection and analysis of user data within product development is occurring in companies worldwide and across all industries. User data can provide a company with information about the users which can be utilized to develop existing and new products. This study aims to explore how a combination of user data and other work methods can identify and satisfy customer needs during the development of websites and apps. To answer the research questions a theoretical framework was built from a scientific literature study. The literature study gives much focus to the Kano model to explain the connection between different customer needs and customer satisfaction. Additionally, common user data and other work methods are presented. Subsequently, a qualitative study was conducted at four companies who are working with product development of apps and/or websites. The qualitative study consisted of semi-structured interviews. The results from the qualitative study were analysed and compared to the theoretical framework. After analysis and discussion, the study shows that a combination of user data and other work methods is profitable in a product development process to achieve high customer satisfaction. Furthermore, the study discovers the difficulties in measuring customer satisfaction since customer needs are constantly changing and also because customer satisfaction is often measured on specific product features, not the product as a whole. inte produkten i sin helhet. Produktutveckling användardata Kano modell basbehov uttalade behov omedvetna behov kundbehov kundtillfredsställelse. Engineering and Technology Teknik och teknologier

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