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This thesis reviews the significance of the 1969 Japan-US Summit between Prime Minister Satii Eisaku and President Richard Nixon in light of official documents that have been disclosed in Japan since 2010 and in the United States since the 1990s. Based on newly available sources, this thesis shows that the 1969 Summit should be considered a Japanese-led initiative with two aims: firstly, to announce a deadline for Okinawa's return with all nuclear weapons removed; and secondly, to reform the Japan-US security treaty system without repeating the kind of outright revision concluded in 1960. The Japanese plan to reform the security treaty system involved simplifying the prior consultation formula by making a public commitment to the security of South Korea of sufficient strength that the United States would agree to the dissolution of the 1960 secret 'Korea Minute'. The Japanese Government achieved its first aim but only partially succeeded in its second. Whilst the return of Okinawa was announced, the status of US bases in Okinawa and mainland Japan continued to be governed by an elaborate web of agreements, public and secret, which damaged public confidence and hampered an improvement in relations between Japan and its neighbouring countries. This thesis shows that commonly held academic opinions about the 1969 Summit are incorrect. Firstly, there was no quid pro quo in which Japan linked its security to South Korea in exchange for Okinawa: both these outcomes were in fact Japanese objectives at the beginning of the summit preparations. Secondly, the success of the summit did not depend on 'backchannel' negotiations between Wakaizumi Kei and Henry Kissinger: it is likely that an announcement on Okinawa's reversion would have been achieved in 1969 even if preparations for the summit had been left to the Japanese Foreign Ministry and the US State Department. Word Limit: Approx. 98,000 words, excluding Bibliography

Intrdodução: As terapias com anticonvulsivantes de anel aromático (ACA) são freqüentemente associadas a reações adversas. No entanto, reações de hipersensibilidade (RH) não-imediatas (tardias) a estes fármacos são raras, imprevisíveis e geralmente relacionadas à alta morbidade e mortalidade. Foi demonstrado que estas RH aos ACA estão fortemente associadas ao Antígenio de Leucócitos Humanos (HLA)-B*1502 em pacientes chineses e ao HLA-A*3101 em caucasianos. Polimorfismos de genes do metabolismo do Citocromo P450 (CYP)2C9 foram mais associados a estas reações em pacientes orientais. Objetivo: Nosso objetivo é analisar a associação das reações de hipersensibilidade a anticonvulsivantes de anel aromático com os polimorfismos descritos e de interesse, bem como realizar a tipificação de HLA em uma população de São Paulo, Brasil. Métodos: Estudo tipo caso-controle com genotipagem dos polimorfismos de interesse por reação em cadeia da polimerase (PCR) em tempo real e tificação de HLA A, B, C, DRB, DQA, DQB por PCR seguido de deteção utilizando método LuminexR. A avaliação fenotípica se baseou em sistemas de escores padronizados, utilizando um questionário adaptado da ENDA (Rede Européia de Alergia a Medicamentos), em registros médicos e no acompanhamento clínico. O teste de contato com o medicamento suspeito foi realizado de acordo com as recomendações da ENDA, nos pacientes que apresentaram reação. Resultados: Foram estudados 506 pacientes, 65% do gênero feminino e a idade média foi de 43,6 anos. Oitenta por cento era de etnia mista. Polimorfismos de HLA-A*3101, HLA-B*1502, CYP2C9, CYP2C19 e CYP3A5 foram analisados de 55 indivíduos com reações de hipersensibilidade (RH) a antiepilépticos, de 85 tolerantes e de 366 controles sadios. Dos 55 casos foram validados como RH, 32 apresentaram Reação a Drogas com eosinofilia e sintomas sistêmicos (DRESS), 12 Síndrome de Stevens-Johnson (SSJ) e 11 exantema maculo-papular. De todos os 46 testes de contato com medicamento, 29 (63%) foram positivos, tanto em SSJ como em DRESS. Houve associação significativa entre polimorfismo de HLA-A*1502 e casos. Nenhum de nossos grupos de estudo apresentou associação positiva com polimorfismos de HLAA* 3101. Verificamos uma forte associação entre a atividade normal do CYP3A5 e indivíduos tolerantes quando comparado com casos (p = 0,0002, OR = 4,8). A tipificação de HLA demonstrou associação significante de HLA-A*31, HLA-A*74, HLA-B*35 e HLA-B*53 com reações graves aos ACA e de HLA-B*44 e HLA-C*03 com indivíduos tolerantes. Conclusão: Estes resultados sugere fortemente a existência de fatores genéticos de risco e/ou de proteção a RH a ACA em indivíduos brasileiros, mas não devem ser considerados de forma isolada. Assim, a relevância deste estudo extrapola o objetivo de estudo caso-controle e sugere um modelo como forma de prevenção primária às RH aos ACA. / Background: Antiepileptics with aromatic ring (AAR) therapies are frequently associated with adverse reactions. Nevertheless non-immediate (late) hypersensitivity reactions (HR) to these drugs are rare, unpredictable and usually related with high morbidity and mortality. A strong pharmacogenetic association has been reported in Chinese patients with these HR and Human Leukocyte Antigen (HLA)-B*1502 and with HLA- A*3101 in caucasians. Polymorphism of genes of P450 Cytocrome (CYP)2C9 has been related to these reactions in patients of oriental origin. Objective: Our aim is to analyze the association between hypersensitivity reactions due to AAR and the described polymorphisms, as well as perform the typification of HLA in a population of São Paulo, Brazil. Methods: Case-control study genotyping the polymorphisms of interest by polymerase chain reaction (PCR) real time and typifying HLA A, B, C, DRB, DQA, DQB by PCR followed by LuminexR .The phenotype evaluation was based on standardized scoring systems using an adapted ENDA (European Network of Drug Allergy) questionnaire, medical records and on the clinical follow-up in our Allergy Clinic. The patch test with the culprit drug was performed in patients who experienced HR according to the ENDA recommendations. Results: We studied 506 subjects, 65% female and mean age was 43,6 years. Eighty percent had mixed ethnicity. Polymorphisms of HLA-B*1502, HLA- A*3101, CYP2C9, CYP2C19 e CYP3A5 were studied in 55 subjects with antiepileptics HR, 85 tolerants, and 366 control subjects. Of 55 cases were validated as AHR, 32 presented Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), 12 Stevens-Johnson Syndrome (SJS) and 11 maculopapular exanthema. Of all 46 drug patch tests, 29 (63%) were positive, in both SJS and DRESS. A significant association between polymorphism of HLA-A*1502 and cases was found. None of our study groups presented positive association with HLA-A*3101 polymorphisms. We found a strong association between the normal activity of CYP3A5 and tolerants subjects when compared to HR (p=0.0002, OR=4.8). The HLA typification showed a significant association between HLA-A*31, HLA-A*74, HLAB* 35 e HLA-B*53 and severe AAR reactions and HLA-B*44 and HLA-C*03 in tolerants subjects. Conclusion: These results strongly suggests the existence of genetic risk and/or protective factors to the development of HR to AAR AAR in Brazilian subjects, but it should not be considered in a isolated manner. So, the relevance of this study extrapolates the aim of a case-control study and suggests a system of primary prevention to HR due to AAR

Intrdodução: As terapias com anticonvulsivantes de anel aromático (ACA) são freqüentemente associadas a reações adversas. No entanto, reações de hipersensibilidade (RH) não-imediatas (tardias) a estes fármacos são raras, imprevisíveis e geralmente relacionadas à alta morbidade e mortalidade. Foi demonstrado que estas RH aos ACA estão fortemente associadas ao Antígenio de Leucócitos Humanos (HLA)-B*1502 em pacientes chineses e ao HLA-A*3101 em caucasianos. Polimorfismos de genes do metabolismo do Citocromo P450 (CYP)2C9 foram mais associados a estas reações em pacientes orientais. Objetivo: Nosso objetivo é analisar a associação das reações de hipersensibilidade a anticonvulsivantes de anel aromático com os polimorfismos descritos e de interesse, bem como realizar a tipificação de HLA em uma população de São Paulo, Brasil. Métodos: Estudo tipo caso-controle com genotipagem dos polimorfismos de interesse por reação em cadeia da polimerase (PCR) em tempo real e tificação de HLA A, B, C, DRB, DQA, DQB por PCR seguido de deteção utilizando método LuminexR. A avaliação fenotípica se baseou em sistemas de escores padronizados, utilizando um questionário adaptado da ENDA (Rede Européia de Alergia a Medicamentos), em registros médicos e no acompanhamento clínico. O teste de contato com o medicamento suspeito foi realizado de acordo com as recomendações da ENDA, nos pacientes que apresentaram reação. Resultados: Foram estudados 506 pacientes, 65% do gênero feminino e a idade média foi de 43,6 anos. Oitenta por cento era de etnia mista. Polimorfismos de HLA-A*3101, HLA-B*1502, CYP2C9, CYP2C19 e CYP3A5 foram analisados de 55 indivíduos com reações de hipersensibilidade (RH) a antiepilépticos, de 85 tolerantes e de 366 controles sadios. Dos 55 casos foram validados como RH, 32 apresentaram Reação a Drogas com eosinofilia e sintomas sistêmicos (DRESS), 12 Síndrome de Stevens-Johnson (SSJ) e 11 exantema maculo-papular. De todos os 46 testes de contato com medicamento, 29 (63%) foram positivos, tanto em SSJ como em DRESS. Houve associação significativa entre polimorfismo de HLA-A*1502 e casos. Nenhum de nossos grupos de estudo apresentou associação positiva com polimorfismos de HLAA* 3101. Verificamos uma forte associação entre a atividade normal do CYP3A5 e indivíduos tolerantes quando comparado com casos (p = 0,0002, OR = 4,8). A tipificação de HLA demonstrou associação significante de HLA-A*31, HLA-A*74, HLA-B*35 e HLA-B*53 com reações graves aos ACA e de HLA-B*44 e HLA-C*03 com indivíduos tolerantes. Conclusão: Estes resultados sugere fortemente a existência de fatores genéticos de risco e/ou de proteção a RH a ACA em indivíduos brasileiros, mas não devem ser considerados de forma isolada. Assim, a relevância deste estudo extrapola o objetivo de estudo caso-controle e sugere um modelo como forma de prevenção primária às RH aos ACA. / Background: Antiepileptics with aromatic ring (AAR) therapies are frequently associated with adverse reactions. Nevertheless non-immediate (late) hypersensitivity reactions (HR) to these drugs are rare, unpredictable and usually related with high morbidity and mortality. A strong pharmacogenetic association has been reported in Chinese patients with these HR and Human Leukocyte Antigen (HLA)-B*1502 and with HLA- A*3101 in caucasians. Polymorphism of genes of P450 Cytocrome (CYP)2C9 has been related to these reactions in patients of oriental origin. Objective: Our aim is to analyze the association between hypersensitivity reactions due to AAR and the described polymorphisms, as well as perform the typification of HLA in a population of São Paulo, Brazil. Methods: Case-control study genotyping the polymorphisms of interest by polymerase chain reaction (PCR) real time and typifying HLA A, B, C, DRB, DQA, DQB by PCR followed by LuminexR .The phenotype evaluation was based on standardized scoring systems using an adapted ENDA (European Network of Drug Allergy) questionnaire, medical records and on the clinical follow-up in our Allergy Clinic. The patch test with the culprit drug was performed in patients who experienced HR according to the ENDA recommendations. Results: We studied 506 subjects, 65% female and mean age was 43,6 years. Eighty percent had mixed ethnicity. Polymorphisms of HLA-B*1502, HLA- A*3101, CYP2C9, CYP2C19 e CYP3A5 were studied in 55 subjects with antiepileptics HR, 85 tolerants, and 366 control subjects. Of 55 cases were validated as AHR, 32 presented Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), 12 Stevens-Johnson Syndrome (SJS) and 11 maculopapular exanthema. Of all 46 drug patch tests, 29 (63%) were positive, in both SJS and DRESS. A significant association between polymorphism of HLA-A*1502 and cases was found. None of our study groups presented positive association with HLA-A*3101 polymorphisms. We found a strong association between the normal activity of CYP3A5 and tolerants subjects when compared to HR (p=0.0002, OR=4.8). The HLA typification showed a significant association between HLA-A*31, HLA-A*74, HLAB* 35 e HLA-B*53 and severe AAR reactions and HLA-B*44 and HLA-C*03 in tolerants subjects. Conclusion: These results strongly suggests the existence of genetic risk and/or protective factors to the development of HR to AAR AAR in Brazilian subjects, but it should not be considered in a isolated manner. So, the relevance of this study extrapolates the aim of a case-control study and suggests a system of primary prevention to HR due to AAR

Syftet med denna fallstudie är att visa på en ökad förståelse kring regeringschefers förmåga att skapa förtroende sin kriskommunikation. Uppsatsen undersöker de tal till nationen som hölls av Sveriges statsminister Stefan Löfven och Storbritanniens premiärminister Boris Johnson vid Covid-19 pandemin under våren och hösten 2020. Uppsatsen utgår från ett retoriskt perspektiv och undersöker talens innehåll utifrån dess transkriberingar. Analysen utgår från uppsatsens teoretiska perspektiv som innefattar retorikens olika delar, appellformer och stilfigurer. Den utgår även från den retoriska situationen. Metoden som används är retorisk analys och utgår från uppsatsens disposition, argumentation, stil och retoriska situation. Den retoriska analysen skapar möjligheten att analysera och tolka talen både i sin helhet men också genom meningar, ord och tecken. Vidare diskuteras resultaten utifrån tidigare forskning och teoretiska perspektiv med ett fokus på politiskt förtroende och kriskommunikation.   Uppsatsen finner resultatet att regeringscheferna använder samtliga retoriska verktyg som undersöks i sina tal. Det framgår även att dessa verktyg används av regeringscheferna i syfte att öka förtroendet för dem som regeringschefer. Utifrån tidigare forskning går det se att både Löfven och Johnson fick ett ökat förtroende en kort tid efter att de första talen genomfördes, vilket indikerar att regeringscheferna kan ha lyckats uppnå ett förtroende genom sin kriskommunikation. / The aim of this case study is to gain more understanding of the head of government's ability to create trust in their crisis communication. The essay examines speeches to the nation, given by the Swedish Prime Minister Stefan Löfven and the British Prime Minister Boris Johnson, during the Covid-19 pandemic in the spring and fall of 2020. The essay uses a rhetorical perspective and examines the content of the speeches based on their transcripts. The analysis is based on the theoretical framework of the essay, which includes the rhetorical theory, three modes of persuasion and the figures of speech. It is also based on the rhetorical situation. The rhetorical analysis is the method used in the case study which focuses on the speech's disposition, argumentation, style and rhetorical situation. The rhetorical analysis makes it possible to analyze and interpret language both in its ensemble, but also through sentences, words, and signs. Furthermore, results based on previous research and theoretical perspectives are discussed with a focus on political trust and crisis communication.   The essay concludes that both Löfven and Johnson use all the rhetorical tools that are examined in their speeches. It is also clear that these tools are used by Löfven and Johnson to gain trust as Heads of Government. Based on previous research, it can be seen that both Löfven and Johnson gained increased trust shortly after their speeches were given, which indicates that the heads of government may have succeeded in gaining confidence through their crisis communication.

The Quorum of the Twelve Apostles for the Church of Jesus Christ of Latter-day Saints is an administrative and ecclesiastical quorum. The Church, first organized in 1830, did not organize the Quorum of Twelve Apostles until 1835. When it was organized, Joseph Smith outlined the quorum's responsibilities through revelation. The Twelve were assigned two unique and specific responsibilities: to take the gospel to the nations of the earth and to form a traveling high council for the regulating of the Church outside of its stakes. The first opportunity for the Twelve to fulfill their responsibilities was in May 1835 when they were assigned to travel to the eastern United States and southern Canada. There they both preached the gospel and regulated the branches of the Church. This mission represents not only the first time the Apostles fulfilled their assigned responsibilities but the only time that they filled their responsibilities as an entire quorum. It is surprising that more secondary literature on this mission is not available. This thesis seeks to commence an academic conversation regarding this mission and its impact both on the quorum's development and on the Church in its outlying areas. Chapter 1 details the preparation of the individual members of the Twelve to fulfill this mission. It discusses the preparation of the Twelve prior to their call to the apostleship. It also discusses the training that took place between their call and the commencement of this mission. As an administrative body for the membership of the Church, the Twelve spent the majority of their time on this mission with the members of the Church. Chapter 2 identifies the unique purpose of the Twelve on this mission and how that purpose was fulfilled. Joseph Smith originally laid out the geographic framework for this mission, which sent the Twelve into Canada and throughout much of the northeastern United States. Chapter 3 identifies the locations of the Twelve based on available records and seeks to provide an answer to how the Twelve decided which areas to preach in. Many individuals were baptized during this five-month mission. Chapter 4 identifies what the Twelve taught and the sources that they used. It also discusses the reaction of the people they taught. The concluding chapter summarizes the thesis and identifies areas for further research.

Thesis (DLitt (Ancient Studies))--University of Stellenbosch, 2006. / This study accounts for the forms and functions of the similes in the Book of Hosea. It proposes new tools for textual criticism, biblical interpretation, and understanding Biblical Hebrew (BH) worldview. Chapter One presents the task we have chosen for ourselves, its nature, some obstacles from other areas of scholarship, and the foundational notions of embodiment and Prototype Theory. Chapter Two presents principles drawn from Cognitive Semantics and Cognitive Syntax. A weakened version of the Lakoff-Johnson conceptual metaphor theory is adopted, and the key notions of embodiment and judgments of prototypicality are presented. Elements of Conceptual Blending are presented and adapted for simile analysis. Finally, text-based differences between metaphors and similes are discussed. Chapter Three presents cognitive cultural constructs of Strauss and Quinn: cultural schemas, cultural exemplars, cultural models, and cultural themes. Strauss and Quinn’s conclusions about metaphors’ use in everyday speech are shown to agree with our postulation of speaker assessment of the hearer’s ability to process utterances before they are produced. This postulation allows us to erect one part of a theory of simile. Chapter Three then integrates metaphor with the Strauss-Quinn cultural meaning model, and then with Boroditsky’s Weak Structuring view of metaphor. The effect is to provide a reasonable basis, amenable to empirical investigation, for the investigation of both metaphor and simile. Finally, the notions of embodiment and prototypicality are applied to the Strauss-Quinn model. Chapter Four presents various assumptions and conclusions that are later used to analyze Hosea’s similes. These include: (1) elements of Floor’s (2004a) model of Information Structure for BH narrative, with modifications and additions for poetry; (2) three cognitive types of similes in Hosea, posited for working purposes; (3) an adaptation of the conceptual blending apparatus to similes; (4) hypotheses to account for the distribution of similes versus that of metaphors in BH poetry, and to account for patterned differences in how various kinds of concepts are combined and manipulated; (5) an integration of these patterns with the three simile types; and (6) correlation of the cultural constructs of cultural schema, cultural theme, and cultural model with Hosea’s similes and metaphors. Chapter Five presents a number of scholarly views of the Book of Hosea, and characterizes the principal authorities cited in the next chapter. Chapter Six deductively applies all the foregoing theory to an examination of Hosea’s similes. Other observations are made inductively: (1) kinaesthetic image schemas’ role in Hosea’s poetry; (2) systematic difference in the use of similes versus metaphors in image elaboration; and (3) Information Structure’s role in simile analysis. Chapter Seven summarizes this study’s research and conclusions concerning, e.g., (1) the criteria for accounting for the embodiment and judgments of prototypicality characterizing Hosea’s similes; (2) the dependence of Hosea and his audience upon knowledge of themselves and their environment for their view of YHWH; and (3) the aid brought by a cognitive theory of similes in the task of textual criticism. Chapter Eight discusses prospects for further research and possible implications for translating Hosea’s similes and metaphors.

Approved for public release; distribution in unlimited. / The dynamics in U.S.-Turkey relations in both 1964 and 2003 continued to be between a large global power and a medium regional power in the framework of a global threat that required regional cooperation. In both cases the priority of the global power was the fight against the global threat and this created expectations from the medium power ally in the region, who -in both cases- had its own reservations about the issue, considering its own national interests. The analysis of the 1964 Crisis shows that both U.S. and Turkey would have five main sources of influence over their foreign policy decisions leading to disagreement in 1964: the dynamics in the U.S. Turkish relations as one between a global power and a regional partner; domestic concerns of both countries; unaligned goals of the two parties; the international circumstances; and the influence of signaling failures and previous interactions. When we analyze the 2003 Crisis in light of these findings we see that all the main issues seem to be consistently relevant, though their effects might have changed slightly. Overall, both cases reveal that the above-mentioned five factors determine the outcome of interactions between large global powers and medium powers in the region. / 1st Lieutenant, Turkish Army

This study provides a feminist analysis of protective labor legislation in the Supreme Court case of UAW v. Johnson Controls, Inc. History of protection rhetoric and precedented cases leading up to UAW are provided. Using a feminist analysis, this study argues that the victory for women's labor rights in UAW is short lived, and the cycle of protection rhetoric continues with new pro-business agendas replacing traditional justifications for "protecting" women in the work place. The implications of this and other findings are discussed.