Global ETD Search

491	The Application of Multiuser Detection to Spectrally Efficient MIMO or Virtual MIMO SC-FDMA Uplinks in LTE Systems. Ben Salem, Aymen January 2014 (has links) Single Carrier Frequency Division Multiple Access (SC-FDMA) is a multiple access transmission scheme that has been adopted in the 4th generation 3GPP Long Term Evolution (LTE) of cellular systems. In fact, its relatively low peak-to-average power ratio (PAPR) makes it ideal for the uplink transmission where the transmit power efficiency is of paramount importance. Multiple access among users is made possible by assigning different users to different sets of non-overlapping subcarriers. With the current LTE specifications, if an SC-FDMA system is operating at its full capacity and a new user requests channel access, the system redistributes the subcarriers in such a way that it can accommodate all of the users. Having less subcarriers for transmission, every user has to increase its modulation order (for example from QPSK to 16QAM) in order to keep the same transmission rate. However, increasing the modulation order is not always possible in practice and may introduce considerable complexity to the system. The technique presented in this thesis report describes a new way of adding more users to an SC-FDMA system by assigning the same sets of subcarriers to different users. The main advantage of this technique is that it allows the system to accommodate more users than conventional SC-FDMA and this corresponds to increasing the spectral efficiency without requiring a higher modulation order or using more bandwidth. During this work, special attentions wee paid to the cases where two and three source signals are being transmitted on the same set of subcarriers, which leads respectively to doubling and tripling the spectral efficiency. Simulation results show that by using the proposed technique, it is possible to add more users to any SC-FDMA system without increasing the bandwidth or the modulation order while keeping the same performance in terms of bit error rate (BER) as the conventional SC-FDMA. This is realized by slightly increasing the energy per bit to noise power spectral density ratio (Eb/N0) at the transmitters. SC-FDMA SC-FDE 3GPP Long Term Evolution Single Carrier Systems Single Carrier Systems Single Carrier FDE Single Carrier FDMA Localized Subcarrier Mapping Distributed Subcarrier Mapping OFDMA MIMO SC-FDMA Spatial Diversity Gain Spatial Multiplexing Gain MIMO Channel SIMO Channel Space Diversity on Receive Techniques Selection Combining Equal-gain Combining Maximal-ratio Combining MRC Channel Equalization Zero-forcing Equalization Minimum Mean-square Error Equalization ZF MMSE SC-FDMA with Multiuser Detection Link Level Simulation V-blast
492	Performance evaluation and protocol design of fixed-rate and rateless coded relaying networks Nikjah, Reza 06 1900 (has links) The importance of cooperative relaying communication in substituting for, or complementing, multiantenna systems is described, and a brief literature review is presented. Amplify-and-forward (AF) and decode-and-forward (DF) relaying are investigated and compared for a dual-hop relay channel. The optimal strategy, source and relay optimal power allocation, and maximum cooperative gain are determined for the relay channel. It is shown that while DF relaying is preferable to AF relaying for strong source-relay links, AF relaying leads to more gain for strong source-destination or relay-destination links. Superimposed and selection AF relaying are investigated for multirelay, dual-hop relaying. Selection AF relaying is shown to be globally strictly outage suboptimal. A necessary condition for the selection AF outage optimality, and an upper bound on the probability of this optimality are obtained. A near-optimal power allocation scheme is derived for superimposed AF relaying. The maximum instantaneous rates, outage probabilities, and average capacities of multirelay, dual-hop relaying schemes are obtained for superimposed, selection, and orthogonal DF relaying, each with parallel channel cooperation (PCC) or repetition-based cooperation (RC). It is observed that the PCC over RC gain can be as much as 4 dB for the outage probabilities and 8.5 dB for the average capacities. Increasing the number of relays deteriorates the capacity performance of orthogonal relaying, but improves the performances of the other schemes. The application of rateless codes to DF relaying networks is studied by investigating three single-relay protocols, one of which is new, and three novel, low complexity multirelay protocols for dual-hop networks. The maximum rate and minimum energy per bit and per symbol are derived for the single-relay protocols under a peak power and an average power constraint. The long-term average rate and energy per bit, and relay-to-source usage ratio (RSUR), a new performance measure, are evaluated for the single-relay and multirelay protocols. The new single-relay protocol is the most energy efficient single-relay scheme in most cases. All the multirelay protocols exhibit near-optimal rate performances, but are vastly different in the RSUR. Several future research directions for fixed-rate and rateless coded cooperative systems, and frameworks for comparing these systems, are suggested. / Communications acknowledgment signals amplify-and-forward relaying average capacity average power constraint bit error rate cooperative gain cooperative communication decode-and-forward relaying degree of freedom direct transmission distributed space-time coding dual-hop relaying energy efficiency energy per bit energy per symbol feedback communication fixed-rate coded relaying fixed-rate codes fixed-rate coding large SNR approximation maximal ratio combining maximum achievable rates maximum likelihood multiple access channels mutual information nonconcave fractional programming numerical optimization optimal power allocation orthogonal relaying outage optimality outage probability parallel channel coding peak power constraint power allocation schemes power fairness protocol design rateless coded relaying rateless codes rate efficiency rateless coding Rayleigh fading relay-to-source usage ratio relaying networks repetition coding selection relaying single-hop communication superimposed relaying symbol error rate
493	Performance evaluation and protocol design of fixed-rate and rateless coded relaying networks Nikjah, Reza Unknown Date No description available. acknowledgment signals amplify-and-forward relaying average capacity average power constraint bit error rate cooperative gain cooperative communication decode-and-forward relaying degree of freedom direct transmission distributed space-time coding dual-hop relaying energy efficiency energy per bit energy per symbol feedback communication fixed-rate coded relaying fixed-rate codes fixed-rate coding large SNR approximation maximal ratio combining maximum achievable rates maximum likelihood multiple access channels mutual information nonconcave fractional programming numerical optimization optimal power allocation orthogonal relaying outage optimality outage probability parallel channel coding peak power constraint power allocation schemes power fairness protocol design rateless coded relaying rateless codes rate efficiency rateless coding Rayleigh fading relay-to-source usage ratio relaying networks repetition coding selection relaying single-hop communication superimposed relaying symbol error rate
494	Development of Sensitive In Vitro Assays to Assess the Ocular Toxicity Potential of Chemicals and Ophthalmic Products McCanna, David January 2009 (has links) The utilization of in vitro tests with a tiered testing strategy for detection of mild ocular irritants can reduce the use of animals for testing, provide mechanistic data on toxic effects, and reduce the uncertainty associated with dose selection for clinical trials. The first section of this thesis describes how in vitro methods can be used to improve the prediction of the toxicity of chemicals and ophthalmic products. The proper utilization of in vitro methods can accurately predict toxic threshold levels and reduce animal use in product development. Sections two, three and four describe the development of new sensitive in vitro methods for predicting ocular toxicity. Maintaining the barrier function of the cornea is critical for the prevention of the penetration of infections microorganisms and irritating chemicals into the eye. Chapter 2 describes the development of a method for assessing the effects of chemicals on tight junctions using a human corneal epithelial and canine kidney epithelial cell line. In Chapter 3 a method that uses a primary organ culture for assessing single instillation and multiple instillation toxic effects is described. The ScanTox system was shown to be an ideal system to monitor the toxic effects over time as multiple readings can be taken of treated bovine lenses using the nondestructive method of assessing for the lens optical quality. Confirmations of toxic effects were made with the utilization of the viability dye alamarBlue. Chapter 4 describes the development of sensitive in vitro assays for detecting ocular toxicity by measuring the effects of chemicals on the mitochondrial integrity of bovine cornea, bovine lens epithelium and corneal epithelial cells, using fluorescent dyes. The goal of this research was to develop an in vitro test battery that can be used to accurately predict the ocular toxicity of new chemicals and ophthalmic formulations. By comparing the toxicity seen in vivo animals and humans with the toxicity response in these new in vitro methods, it was demonstrated that these in vitro methods can be utilized in a tiered testing strategy in the development of new chemicals and ophthalmic formulations. in vitro Alternative Methods alamarBlue rhodamine tight junctions bovine lens viability toxicity mitochondria mitochondria integrity benzalkonium chloride sodium dodecyl sulphate sodium lauryl sulfate scanning electron microscopy Draize Draize maximal average scores zonula occludens cosmetic directive PETA humane society animal league ICCVAM ECVAM JaCVAM BCOP bovine cornea ocular irritants ocular irritation ocular toxicity human corneal epithelial cells vitro confocal confocal microscopy metabolic activity optical quality reactive oxygen species contact lens contact lens care solutions barrier function microbial keratitis mulitipurpose solutions tight junction cell damage claudin ZO-1 occludin MDCK Madin Madin-Darby canine kidney cells cornea human cornea human corneal epithelium epithelial cell line human corneal epithelial cell line sodium fluorescein sodium fluorescein permeability fluorescein permeability ocular surface cell monolayer Araki-Sasaki cell physiology risk assessment safety assessment ScanTox scanning laser lens epithelium corneal cells in vitro model ophthalmic formulations multiple instillation back vertex animal testing rabbit testing alternatives to animal testing cultured bovine lens toxicity of chemicals irritation irritants laser scanner organ culture delayed toxicity toxins hydrogen peroxide cornea toxicity cornea toxicity models prediction of human toxicity no observable adverse effect level lowest observable adverse effect level NOAEL LOAEL toxicity thresholds safety factors cornea uncertainty factors preservatives disinfectants ophthalmic products preclinical preclinical testing epithelial barrier drug penetration clinical confocal microscopy animal rights rabbit cornea human cornea human clinical effects toxic animal rights activist sensitive measures toxic effect toxicity threshold agar overlay agar diffusion agar overlay method agar diffusion method cytochrome cytochrome c apoptosis necrotic apoptotic necrosis caspase rhodamine 123 resazuran resorufin cell death cell viability metabolic dye microsomal microsomal enzymes cytotoxicity cytotoxic cytotoxic effect MTT XTT WST-1 plasma membrane mitochondrial mitochondrial morphology ocular toxicity potential ocular toxicity human corneal epithelial cell line confocal analysis corneal epithelium cell fluorescence alamarBlue assay rhodamine dye animal welfare toxic injury degraded mitochondria epithelial monolayer disinfectants membrane integrity eye toxicity eye viability dye toxicity in humans human toxicity effects on the mitochondria mitochondrial toxicity in vitro battery in vitro test battery ophthalmic eye drop direct contact product safety cytotoxicity potential molecular molecular biology refine reduce replace sensitivity and relevance sensitivity relevance rabbit ocular irritation test product development cytotoxicity models cytotoxicity alternative methods replacements for animal testing three r's beagle tiered testing tiered testing strategy replacements animal testing mechanistic toxicity cornea mitochondria dose response threshold Vision Science and Biology
495	Development of Sensitive In Vitro Assays to Assess the Ocular Toxicity Potential of Chemicals and Ophthalmic Products McCanna, David January 2009 (has links) The utilization of in vitro tests with a tiered testing strategy for detection of mild ocular irritants can reduce the use of animals for testing, provide mechanistic data on toxic effects, and reduce the uncertainty associated with dose selection for clinical trials. The first section of this thesis describes how in vitro methods can be used to improve the prediction of the toxicity of chemicals and ophthalmic products. The proper utilization of in vitro methods can accurately predict toxic threshold levels and reduce animal use in product development. Sections two, three and four describe the development of new sensitive in vitro methods for predicting ocular toxicity. Maintaining the barrier function of the cornea is critical for the prevention of the penetration of infections microorganisms and irritating chemicals into the eye. Chapter 2 describes the development of a method for assessing the effects of chemicals on tight junctions using a human corneal epithelial and canine kidney epithelial cell line. In Chapter 3 a method that uses a primary organ culture for assessing single instillation and multiple instillation toxic effects is described. The ScanTox system was shown to be an ideal system to monitor the toxic effects over time as multiple readings can be taken of treated bovine lenses using the nondestructive method of assessing for the lens optical quality. Confirmations of toxic effects were made with the utilization of the viability dye alamarBlue. Chapter 4 describes the development of sensitive in vitro assays for detecting ocular toxicity by measuring the effects of chemicals on the mitochondrial integrity of bovine cornea, bovine lens epithelium and corneal epithelial cells, using fluorescent dyes. The goal of this research was to develop an in vitro test battery that can be used to accurately predict the ocular toxicity of new chemicals and ophthalmic formulations. By comparing the toxicity seen in vivo animals and humans with the toxicity response in these new in vitro methods, it was demonstrated that these in vitro methods can be utilized in a tiered testing strategy in the development of new chemicals and ophthalmic formulations. in vitro Alternative Methods alamarBlue rhodamine tight junctions bovine lens viability toxicity mitochondria mitochondria integrity benzalkonium chloride sodium dodecyl sulphate sodium lauryl sulfate scanning electron microscopy Draize Draize maximal average scores zonula occludens cosmetic directive PETA humane society animal league ICCVAM ECVAM JaCVAM BCOP bovine cornea ocular irritants ocular irritation ocular toxicity human corneal epithelial cells vitro confocal confocal microscopy metabolic activity optical quality reactive oxygen species contact lens contact lens care solutions barrier function microbial keratitis mulitipurpose solutions tight junction cell damage claudin ZO-1 occludin MDCK Madin Madin-Darby canine kidney cells cornea human cornea human corneal epithelium epithelial cell line human corneal epithelial cell line sodium fluorescein sodium fluorescein permeability fluorescein permeability ocular surface cell monolayer Araki-Sasaki cell physiology risk assessment safety assessment ScanTox scanning laser lens epithelium corneal cells in vitro model ophthalmic formulations multiple instillation back vertex animal testing rabbit testing alternatives to animal testing cultured bovine lens toxicity of chemicals irritation irritants laser scanner organ culture delayed toxicity toxins hydrogen peroxide cornea toxicity cornea toxicity models prediction of human toxicity no observable adverse effect level lowest observable adverse effect level NOAEL LOAEL toxicity thresholds safety factors cornea uncertainty factors preservatives disinfectants ophthalmic products preclinical preclinical testing epithelial barrier drug penetration clinical confocal microscopy animal rights rabbit cornea human cornea human clinical effects toxic animal rights activist sensitive measures toxic effect toxicity threshold agar overlay agar diffusion agar overlay method agar diffusion method cytochrome cytochrome c apoptosis necrotic apoptotic necrosis caspase rhodamine 123 resazuran resorufin cell death cell viability metabolic dye microsomal microsomal enzymes cytotoxicity cytotoxic cytotoxic effect MTT XTT WST-1 plasma membrane mitochondrial mitochondrial morphology ocular toxicity potential ocular toxicity human corneal epithelial cell line confocal analysis corneal epithelium cell fluorescence alamarBlue assay rhodamine dye animal welfare toxic injury degraded mitochondria epithelial monolayer disinfectants membrane integrity eye toxicity eye viability dye toxicity in humans human toxicity effects on the mitochondria mitochondrial toxicity in vitro battery in vitro test battery ophthalmic eye drop direct contact product safety cytotoxicity potential molecular molecular biology refine reduce replace sensitivity and relevance sensitivity relevance rabbit ocular irritation test product development cytotoxicity models cytotoxicity alternative methods replacements for animal testing three r's beagle tiered testing tiered testing strategy replacements animal testing mechanistic toxicity cornea mitochondria dose response threshold Vision Science and Biology

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