Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2016-10-14T17:51:40Z No. of bitstreams: 1 2015 - Sandra Aparecida Kitakawa Lima.pdf: 2432759 bytes, checksum: 507c18959779e5fc9eea3cc4761ef0f3 (MD5) / Made available in DSpace on 2016-10-14T17:51:40Z (GMT). No. of bitstreams: 1 2015 - Sandra Aparecida Kitakawa Lima.pdf: 2432759 bytes, checksum: 507c18959779e5fc9eea3cc4761ef0f3 (MD5) Previous issue date: 2015-12-21 / CNPq / Based on the survey conducted in a rural settlement field research of agrarian reform and ?quilombo? community in the municipality of Camamu - Bahia, we initially follow the emergence of claims and justification of the residents themselves in situations of disputes and uncertainties facing the government, or rather, the needs and difficulties, which they configured in collective issues being publicly exposed and problematize in public scenes. From two different contexts, we try to understand how the actors obtained (or not) the attention and public responses and the different moralities driven to justify their actions and attitudes towards each other, to build speeches about their feelings of justice or even to guide their performances. Although they were visible and recognized to some extent by the state and its institutions that did not mean that their unique problems were addressed and resolved by public "prioritiy" actions directed to agrarian reform beneficiary public and quilombo communities. On the contrary, they faced with enormous difficulties of enforcement of legal provisions and public policies to their particularities, in addition to multiple costs derived of the claims that, in principle, are rights defined by the Constitution. Thus, the conformation of collective life in daily life, which rests on different concrete practices conducted by a multiplicity of logic and feelings, which allows a "common citizen" to be set up as a "subject of law". / Com base na pesquisa de campo realizada em um assentamento rural de reforma agr?ria e uma comunidade quilombola, no munic?pio de Camamu ? Bahia, acompanhamos inicialmente a emerg?ncia das reivindica??es e justificativas dos pr?prios moradores frente a situa??es de disputas e incertezas na rela??o com o poder p?blico, ou melhor, das necessidades e dificuldades, que se configuravam em quest?es coletivas sendo expostas e problematizadas nas cenas p?blicas. A partir de dois contextos distintos, buscamos compreender de que forma os atores captavam (ou n?o) a aten??o e respostas p?blicas aos problemas vivenciados, bem como as diferentes moralidades acionadas a fim de justificar suas a??es e atitudes face ao outro, de construir discursos sobre seus sentimentos de justi?a ou mesmo de guiar suas performances. Embora fossem vis?veis e reconhecidos, em certa medida, pelo Estado e suas institui??es, isso n?o significava que seus problemas singulares fossem tratados e solucionados por a??es p?blicas ?priorit?rias? direcionadas aos p?blicos de reforma agr?ria e comunidades quilombolas. Ao contr?rio, defrontavam-se com enormes dificuldades de efetiva??o dos dispositivos legais e das pol?ticas p?blicas direcionadas ?s suas particularidades, al?m dos m?ltiplos custos decorrentes das reivindica??es que, a princ?pio, s?o direitos definidos pela Constitui??o Federal. Assim, a conforma??o da vida coletiva no cotidiano, a qual se repousa em diferentes pr?ticas concretas conduzidas por uma multiplicidade de l?gicas e sentimentos, que permite um ?cidad?o comum? se configurar como um ?sujeito de direito?

Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2018-01-24T18:53:40Z No. of bitstreams: 1 2016 - Paulo Rodrigues Fernandes Pereira.pdf: 6898649 bytes, checksum: a748ed315051e906a62367f6bb6f07d1 (MD5) / Made available in DSpace on 2018-01-24T18:53:40Z (GMT). No. of bitstreams: 1 2016 - Paulo Rodrigues Fernandes Pereira.pdf: 6898649 bytes, checksum: a748ed315051e906a62367f6bb6f07d1 (MD5) Previous issue date: 2016-10-14 / CAPES / L'objectif de cette th?se est d'analyser la cha?ne de production du soja sous l'?il critique des transformations qui se produisent dans l'environnement productif avec l'entr?e de nouveaux acteurs et comment la dynamique du financement de la production et les facteurs physiques transforment l'environnement. L'approche th?orique de cette th?se est bas?e sur l'approche des r?gimes alimentaires qui se sont apparemment reconfigur?s eux-m?mes, non plus bas?s sur un pays, mais apparemment sur les grandes entreprises, qui se positionnent non seulement en un lieu, mais ? travers plusieurs continents, absorbant de chacun caract?ristiques locales qui permettront un avantage concurrentiel global. Analyser les cha?nes de valeur mondiales et les cha?nes de produits mondiaux, en identifiant comment les forces qui op?rent sur ce march? sont transform?es et ? travers les diff?rents mod?les de financement, d'?tablissement des co?ts, d'investissement et de commercialisation; L'occupation des zones a de nouvelles caract?ristiques. L'intention est d'identifier qui sont ces nouveaux acteurs et comment ils affectent le sc?nario des acteurs dominants. Quelques outils simples ont transform? le march? et attir? des capitaux financiers de divers endroits, y compris les march?s mondiaux, pour financer et autonomiser les producteurs ruraux. Cette ?tude a fonctionn? avec l'hypoth?se que la restructuration de la cha?ne de production de soja ouvrirait une attente pour les nouveaux entrants. Le r?sultat de cette th?se montre un affaiblissement des grands acteurs ABCD, qui, m?me en maintenant leur h?g?monie, sont affaiblis par les mouvements d'acteurs nouveaux, en particulier les Japonais et les Chinois, qui sont venus au Br?sil avec un d?sir de reconfiguration de ces zones, agissant d'abord discr?tement, Mais incisive dans l'approvisionnement en mati?res premi?res, la production, le concassage, la transformation et l'exportation. / The objective of this thesis is to analyze the soybean production chain under the critical eye of the transformations that are taking place in the productive environment, with the entry of new actors, and how the dynamics of production financing and physical factors are transforming the environment. The theoretical approach of this thesis is based on the approach of food regimes, which seemingly reconfigured themselves, no longer based on a country, but apparently on large corporations, that position themselves not only in one place, but across several continents, absorbing from each place the characteristics that will permit a global competitive advantage. Analyzing the Global Value Chains and Global Commodity Chains, identifying how the forces that operate in this market are transformed and through the various models of financing, for costing, investment and commercialization; The occupation of the areas has new characteristics. The intention is identifying who these new actors are and how they affect the scenario of the dominant actors. Some simple tools transformed the market and attracted financial capital from various locations, including global ones, to finance and empower rural producers. This study worked with the hypothesis that the restructure of the soybean production chain would open an expectation for new entrants. The result of this thesis points to a weakening of the great actors ABCD, that, even maintaining their hegemony, are weakened by new actors movements, especially the Japanese and Chinese, who came to Brazil with a reconfiguration desire of these areas, initially acting discreetly, but incisive in raw materials supply, production, crushing, processing and export. / O objetivo desta tese ? analisar a cadeia produtiva da soja sob o olhar cr?tico das transforma??es que vem ocorrendo no ambiente produtivo, com a entrada de novos atores, e como a din?mica do financiamento da produ??o e dos fatores f?sicos est? transformando o ambiente. A abordagem te?rica desta tese parte da abordagem dos regimes alimentares, que aparentemente se reconfiguram, n?o mais baseados num pa?s, mas aparentemente nas grandes corpora??es que se posicionam n?o apenas num local, mas ao longo de v?rios continentes, absorvendo de cada local as caracter?sticas que lhe permitir?o um diferencial competitivo globalmente. Faz-se a an?lise das Cadeias Globais de Valor e Cadeias Globais de Commodities, identificando como as for?as que atuam neste mercado se transformam e atrav?s dos diversos modelos de financiamento, para o custeio, investimento e comercializa??o; o espa?o tem novas caracter?sticas. Pretende-se identificar quem s?o estes novos atores e como eles afetam o cen?rio dos atores dominantes. Algumas ferramentas simples transformaram o mercado e atra?ram o capital financeiro de diversos locais, inclusive globais, para financiar e empoderar o produtor rural. Trabalhou-se com a hip?tese que a reestrutura??o da cadeia produtiva da soja abriria uma expectativa para novos entrantes. O resultado desta tese aponta para um enfraquecimento dos grandes atores ABCD, que apensar de n?o perderem a hegemonia, ficam enfraquecidos com os novos movimentos de entrada de atores, em especial os japoneses e chineses que chegam ao Brasil com vontade de reconfigurar estes espa?os, atuando de maneira inicialmente discreta, mas incisiva no fornecimento de mat?rias-primas, produ??o, esmagamento, processamento e exporta??o.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-11-22T20:29:37Z No. of bitstreams: 1 AnneEmiliaCostaCarvalho_TESE.pdf: 3379749 bytes, checksum: 9cca5d6710d5607cf545e0d729f057e2 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-11-23T20:53:06Z (GMT) No. of bitstreams: 1 AnneEmiliaCostaCarvalho_TESE.pdf: 3379749 bytes, checksum: 9cca5d6710d5607cf545e0d729f057e2 (MD5) / Made available in DSpace on 2017-11-23T20:53:07Z (GMT). No. of bitstreams: 1 AnneEmiliaCostaCarvalho_TESE.pdf: 3379749 bytes, checksum: 9cca5d6710d5607cf545e0d729f057e2 (MD5) Previous issue date: 2017-07-07 / No Brasil, alguns dos problemas cr?ticos do setor de saneamento b?sico s?o o relevante d?ficit de acesso aos servi?os de abastecimento de ?gua e esgotamento sanit?rio, a dificuldade dos prestadores de servi?os de ?gua e esgoto (PSAEs) de executarem investimentos e a presen?a de inefici?ncias de opera??o e manuten??o. Como alternativa para superar essas quest?es, o novo marco regulat?rio, institu?do em 2007, fortaleceu a regula??o e estabeleceu, entre seus objetivos regulat?rios, a universaliza??o do acesso e a efici?ncia dos sistemas. Nesse sentido, a presente tese busca analisar o impacto da regula??o sobre a efici?ncia dos PSAEs no Brasil. Para tanto, foi configurado um modelo de an?lise envolt?ria de dados (DEA), in?dito para o setor, que permite a avalia??o da efici?ncia din?mica global e das estruturas internas dos PSAEs, por meio de uma rede composta por 3 divis?es interligadas para refletir os objetivos regulat?rios: 1) Expans?o/Melhoria de Sistemas de Abastecimento de ?gua (SAA); 2) Expans?o/Melhoria de Sistemas de Esgotamento Sanit?rio (SES); e 3) Opera??o/Manuten??o de SAA e SES. Aplicou-se o modelo DEA Network Din?mico para 156 PSAEs, no per?odo de 2006 a 2015, e os resultados indicaram baixos n?veis de efici?ncia global. A divis?o de Expans?o/Melhoria de SAA obteve os melhores escores m?dios de efici?ncia, seguida pela divis?o de Opera??o/Manuten??o de SAA e SES e pela divis?o de Expans?o/Melhoria de SES. Os PSAEs regulados apresentaram melhores m?dias de efici?ncia no caso das divis?es de Expans?o/Melhoria de SAA e Opera??o/Manuten??o de SAA e SES. Na segunda etapa da pesquisa, uma an?lise de conte?do das normas de 52 reguladores identificou a presen?a de incentivos regulat?rios em seis categorias tem?ticas propostas: 1) Regime tarif?rio; 2) Atualiza??o de n?veis tarif?rios; 3) Expans?o e melhoria dos sistemas; 4) Condi??es gerais e qualidade da presta??o dos servi?os; 5) Gest?o empresarial; e 6) Transpar?ncia e responsabiliza??o. A an?lise destas categorias de incentivos revelou mudan?as na forma de atua??o dos reguladores ao longo do tempo e apontou fragilidades, como a baixa utiliza??o de metas regulat?rias e mecanismos tarif?rios de indu??o ? efici?ncia. A identifica??o de incentivos regulat?rios tamb?m permitiu a constru??o de um conjunto de vari?veis representativas da regula??o, que foram aplicadas nos modelos de dados em painel para aferi??o do impacto da regula??o sobre a efici?ncia dos PSAEs. Os resultados obtidos na ?ltima etapa de an?lise permitiram a confirma??o da hip?tese central da tese, de que reguladores atuantes, quanto ? defini??o de mecanismos de incentivos, impactam positivamente a efici?ncia dos PSAEs no Brasil. As novas vari?veis, em conjunto com a an?lise espec?fica para cada uma das divis?es do modelo DEA Network Din?mico, ampliou a discuss?o acerca do impacto da regula??o sob a perspectiva da aplica??o de diferentes estrat?gias regulat?rias, demonstrando que a escolha de incentivos regulat?rios, a intensidade da aplica??o desses incentivos e, at? mesmo, o n?mero de entidades reguladoras atuantes, s?o aspectos decisivos para a efici?ncia dos PSAEs. / In Brazil, some of the critical problems of the sanitation sector are the relevant deficit of water and sewage services, the difficulty of water and sewerage companies (WaSCs) to carry out investments and the existence of operating and maintenance inefficiencies. As an alternative to overcome these issues, the new regulatory framework, enacted in 2007, strengthened regulation and established among its regulatory objectives the universal access and water and sewerage systems efficiency. In this sense, this thesis aims to analyze the impact of regulation on the WaSCs efficiency in Brazil. To this end, we configured a data envelopment analysis (DEA) model unprecedented for the sector, which allows the evaluation of the overall dynamic efficiency and it also allows the evaluation of internal structures efficiency of WaSCs, through a network consisting of 3 interconnected divisions to reflect the regulatory objectives: 1) Expansion/Improvement of Water System; 2) Expansion/Improvement of Sewerage System; and 3) Operation/Maintenance of Water and Sewerage Systems. We ran a Dynamic and Network DEA model for 156 WaSCs in the period 2006-2015 and the results indicated low levels of overall efficiency. The Expansion/Improvement of Water System division achieved the best average efficiency scores, followed by the Operation/Maintenance of Water and Sewerage Systems division and the Expansion/Improvement of Sewerage System division. Regulated WaSCs presented better efficiency measures in the case of Expansion/Improvement of Water System and Operation/Maintenance of Water and Sewerage Systems divisions. In the second stage of the research, a content analysis of the standards issued by 52 regulators identified the presence of regulatory incentives in six proposed thematic categories: 1) Tariff regime; 2) Updating tariffs levels; 3) Systems expansion and improvement; 4) General standards and quality of services provision; 5) Management; and 6) Transparency and accountability. The content analysis of these incentives categories revealed changes in regulators strategies over time and indicated weaknesses, such as a low use of regulatory goals and tariff mechanisms that induce efficiency and productivity gains. The identification of regulatory incentives also allowed the construction of a set of variables capable to represent the regulation, that we applied on panel data models to assess the impact of regulation on WaSCs efficiency. The results obtained in the last stage of analysis allowed confirmation of the central hypothesis of this thesis, that active regulators, regarding the definition of incentive mechanisms, positively impact the WaSCs efficiency in Brazil. The new variables, along with a specific analysis for each Dynamic and Network DEA model division, broaden a discussion about the impact of regulation from a perspective of applying different regulatory strategies, demonstrating that choice of regulatory incentives, the intensity of these incentives and even the number of active regulators are decisive for the WaSCs efficiency.

Submitted by Gustavo Gomes (gustavolascasas@gmail.com) on 2013-11-12T12:16:33Z No. of bitstreams: 1 Regula????o e desempenho de servi??os p??blicos em regime de concess??o.pdf: 12414617 bytes, checksum: baeb55ebaa9a6b037cc50d7240b32e4a (MD5) / Approved for entry into archive by Roger Guedes (roger.guedes@fjp.mg.gov.br) on 2013-11-13T18:20:45Z (GMT) No. of bitstreams: 1 Regula????o e desempenho de servi??os p??blicos em regime de concess??o.pdf: 12414617 bytes, checksum: baeb55ebaa9a6b037cc50d7240b32e4a (MD5) / Made available in DSpace on 2013-11-13T18:20:45Z (GMT). No. of bitstreams: 1 Regula????o e desempenho de servi??os p??blicos em regime de concess??o.pdf: 12414617 bytes, checksum: baeb55ebaa9a6b037cc50d7240b32e4a (MD5) Previous issue date: 2013 / - / O desenvolvimento do transporte ferrovi??rio no Brasil teve diferentes fases, que foram marcadas por distintas formas de participa????o do Estado na provis??o e regula????o desse servi??o p??blico (incluindo o per??odo em que o mesmo acumulou as duas fun????es, entre as d??cadas de 1950 e 1990). Os graves problemas estruturais e financeiros que atingiram o sistema ferrovi??rio brasileiro a partir da d??cada de 1980 levaram o setor a ser privatizado na d??cada seguinte. Nesse ??nterim, a desestatiza????o do sistema ferrovi??rio brasileiro acompanhou uma tend??ncia internacional de privatiza????o e desregulamenta????o de setores de infraestrutura, o que ocorreu no rastro das reformas de orienta????o neoliberal promovidas ap??s a deflagra????o da crise do Estado na d??cada de1970. Nesse novo contexto, a regula????o deve, fundamentalmente, ter a miss??o de incentivar e garantir os investimentos necess??rios, proteger os usu??rios, promover o bem-estar da sociedade e aumentar a efici??ncia da presta????o desse servi??o p??blico. Nesse sentido, a reestrutura????o do sistema ferrovi??rio brasileiro implicou no estabelecimento de um marco regulat??rio, que, atualmente, vem sendo revisado e aperfei??oado. O presente trabalho tem como objetivo mais geral analisar a rela????o entre a regula????o (especialmente o marco regulat??rio) do transporte ferrovi??rio de cargas brasileiro e o desenvolvimento do setor no per??odo p??s-privatiza????es. Nesse sentido, s??o examinados os alcances e limites do marco regulat??rio, institu??do no bojo das privatiza????es, no que tange ?? promo????o dos objetivos e fins pretendidos com a regula????o do servi??o p??blico de transporte ferrovi??rio de cargas, quais sejam garantir a viabilidade econ??mica da atividade, criar condi????es para investimentos em melhoria e expans??o de sua presta????o e, notadamente, assegurar a observ??ncia do interesse p??blico no que diz respeito ao padr??o de oferta (em termos de regularidade, efici??ncia e de aumento da produ????o e da qualidade da oferta). Constatou-se que a regula????o p??sprivatiza????o foi capaz de viabilizar a consecu????o de alguns avan??os importantes em termos de aumento global da produ????o ferrovi??ria e da seguran??a do transporte ferrovi??rio de cargas (aspectos parametrizados do marco regulat??rio), mas fracassou ao n??o evitar a ocorr??ncia de distor????es como a baixa competitividade, a pouca integra????o da malha e a forte concentra????o de investimentos, de tipos de cargas transportadas e da utiliza????o efetiva da malha em poucos trechos de maior rentabilidade comercial para as empresas. A an??lise empreendida no trabalho sugere que o padr??o de oferta do transporte ferrovi??rio de cargas se aproximou muito mais dos objetivos empresariais das concession??rias, que, de acordo com a sua l??gica comercial, tendem a explorar a malha ferrovi??ria apenas nos trechos (e para o transporte das mercadorias) que lhes sejam mais rent??veis, do que do interesse p??blico, que envolve, conforme cunhado na abordagem te??rica da regula????o, a presta????o do servi??o de forma eficiente (cujos custos e benef??cios garantam o bem-estar da sociedade), em condi????es adequadas de disponibilidade e qualidade e, n??o menos importante, com vistas ?? sua expans??o e ?? modicidade das tarifas cobradas pela sua presta????o. / The development of rail transport in Brazil had different phases, which were marked by various forms of state participation in the provision and regulation of this utility (including the period in which it accumulated the two functions, between the 1950s and 1990). The severe financial and structural problems that hit Brazil's railway system from the 1980s led the industry to be privatized in the next decade. Meanwhile, the privatization of the Brazilian railway system followed an international trend of deregulation and privatization of infrastructure sectors, which occurred in the wake of neoliberal reforms promoted after the outbreak of the crisis in the state de1970 decade. In this new context, the regulation should basically have the mission to encourage and ensure the necessary investments, protect users, promote the welfare of society and increase efficiency in the delivery of public services. In this sense, the restructuring of the Brazilian railway system resulted in the establishment of a regulatory framework, which currently is being revised and improved. The present study aims to examine the relationship between regulation (especially the regulatory framework) of the Brazilian rail freight and the development of this sector in the post-privatization. Accordingly, we examine the reaches and limitations of the regulatory framework established in the wake of privatization, when it comes to promoting the goals and purpose with the regulation of public rail cargo, namely ensuring the economic viability of the activity, create conditions for investment in improving and expanding its provision and, in particular, ensure compliance with public interest as regards the standard offer (in terms of regularity, efficiency and increased production and quality of its supply). It was found that the post-privatization regulation was able to facilitate the achievement of some important advances in terms of global increased of the production and the safety of rail freight (parameterized aspects of the regulatory framework), but failed to prevent the occurrence of some distortions such as low competitiveness, poor integration of the railway network and the strong concentration of investments, types of cargo carried and the effective use of the railway network in a few rail stretch largest commercial profitability for companies. The analysis in this paper suggests that the pattern of provision of rail freight approached more of the business objectives of the concessionary companies, which, according to your business logic, tend to explore the railway only in rails stretch (and for transportation of the goods) which are more profitable, than the public interest, which involves, as coined in the theoretical approach of regulation, the provision of the utility efficiently (whose costs and benefits ensure the well-being of society), under appropriate conditions availability and quality and, not least, with a view to its expansion and the reasonableness of the fees charged for its provision. / Economia e Finan??as

Made available in DSpace on 2014-12-17T14:03:36Z (GMT). No. of bitstreams: 1 JullianeTAM_TESE_Parcial.pdf: 7138229 bytes, checksum: a06700fccf67cc2db086f62bf86db506 (MD5) Previous issue date: 2014-02-26 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico / studies using UV as a source of DNA damage. However, even though unrepaired UV-induced DNA damages are related to mutagenesis, cell death and tumorigenesis, they do not explain phenotypes such as neurodegeneration and internal tumors observed in patients with syndromes like Xeroderma Pigmentosum (XP) and Cockayne Syndrome (CS) that are associated with NER deficiency. Recent evidences point to a role of NER in the repair of 8-oxodG, a typical substrate of Base Excision Repair (BER). Since deficiencies in BER result in genomic instability, neurodegenerative diseases and cancer, it was investigated in this research the impact of XPC deficiency on BER functions in human cells. It was analyzed both the expression and the cellular localization of APE1, OGG1 e PARP-1, the mainly BER enzymes, in different NER-deficient human fibroblasts. The endogenous levels of these enzymes are reduced in XPC deficient cells. Surprisingly, XP-C fibroblasts were more resistant to oxidative agents than the other NER deficient fibroblasts, despite presenting the highest of 8-oxodG. Furthermore, subtle changes in the nuclear and mitochondrial localization of APE1 were detected in XP-C fibroblasts. To confirm the impact of XPC deficiency in the regulation of APE1 and OGG1 expression and activity, we constructed a XPC-complemented cell line. Although the XPC complementation was only partial, we found that XPC-complemented cells presented increased levels of OGG1 than XPC-deficient cells. The extracts from XPC-complemented cells also presented an elevated OGG1 enzimatic activity. However, it was not observed changes in APE1 expression and activity in the XPCcomplemented cells. In addition, we found that full-length APE1 (37 kDa) and OGG1- ? are in the mitochondria of XPC-deficient fibroblasts and XPC-complemented fibroblasts before and after induction of oxidative stress. On the other hand, the expression of APE1 and PARP-1 are not altered in brain and liver of XPC knockout mice. However, XPC deficiency changed the APE1 localization in hypoccampus and hypothalamus. We also observed a physical interaction between XPC and APE1 proteins in human cells. In conclusion, the data suggest that XPC protein has a role in the regulation of OGG1 expression and activity in human cells and is involved mainly in the regulation of APE1 localization in mice. Aditionally, the response of NER deficient cells under oxidative stress may not be only associated to the NER deficiency per se, but it may include the new functions of NER enzymes in regulation of expression and cell localization of BER proteins / A maior parte do nosso conhecimento sobre a via de Reparo de Excis?o Nucleot?deos (NER) vem de estudos usando a luz ultravioleta (UV) como fonte de danos no DNA. Contudo, embora os danos no DNA causados pela luz UV sejam relacionados ? ocorr?ncia de mutag?nese, morte celular e tumorig?nese, eles n?o justificam fen?tipos como neurodegenera??o e tumorig?nese observados em pacientes com s?ndromes como Xeroderma Pigmentosum (XP) e S?ndrome de Cockayne (CS), as quais s?o associadas ? defici?ncia na via NER. Adicionalmente, evid?ncias mais recentes indicam o envolvimento da via NER no reparo de 8-oxodG, um substrato t?pico da via de Reparo por Excis?o de Bases (BER). Uma vez que a defici?ncia na via BER resulta em instabilidade gen?mica, doen?as neurodegenerativas e c?ncer, foi investigado neste trabalho o impacto da defici?ncia em XPC nas fun??es da via BER em c?lulas humanas. Foram realizadas an?lises da express?o e da localiza??o celular de APE1, OGG1 e PARP-1, principais enzimas da via BER, em fibroblastos humanos deficientes na via NER. Os resultados demonstraram que os n?veis end?genos de APE1, PARP-1 e OGG1 s?o reduzidos nos fibroblastos deficientes em XPC, os quais foram mais resistentes a diferentes tipos de agentes oxidantes e apresentaram n?veis elevados de 8-oxodG quando comparados aos demais fibroblastos deficientes na via NER. Adicionalmente, altera??es sutis na localiza??o nuclear e mitocondrial de APE1 foram observadas nos fibroblastos deficientes em XPC. Para confirmar o impacto da defici?ncia de XPC na regula??o da express?o e atividade de APE1 e OGG1, foi constru?da uma linhagem complementada com XPC. Embora a complementa??o tenha sido parcial, foi poss?vel observar que os fibroblastos parcialmente complementados com XPC apresentaram n?veis maiores de express?o de OGG1 quando comparados aos fibroblastos deficientes em XPC. Os extratos dos fibroblastos parcialmente complementados com XPC tamb?m apresentaram uma elevada atividade enzim?tica de OGG1. Contudo, n?o foram observadas mudan?as na express?o e atividade de APE1 nos fibroblastos parcialmente complementados com XPC. Adicionalmente, foi poss?vel verificar a presen?a da forma completa de APE1 (37 kDa) e de OGG1-? na mitoc?ndria dos fibroblastos deficientes em XPC e parcialmente complementados com XPC. Por outro lado, observou-se que a express?o de APE1 e PARP-1 n?o ? alterada no c?rebro e f?gado de camundongos knockouts para XPC. Contudo, a defici?ncia em XPC resultou em mudan?as na localiza??o celular de APE1 no hipocampo e hipot?lamo. Ainda, foi observada a ocorr?ncia de uma intera??o f?sica entre as prote?nas XPC e APE1 em c?lulas humanas. Em conclus?o, os dados sugerem que a prote?na XPC possui um papel na regula??o da express?o e da atividade de OGG1 em c?lulas humanas e est? envolvida na regula??o da localiza??o celular de APE1 principalmente em camundongos. Adicionalmente, as respostas celulares dos fibroblastos deficientes na via NER ao estresse oxidativo podem n?o estar associadas ? defici?ncia na via NER per se, mas podem incluir novas fun??es das enzimas da via NER na regula??o da express?o e localiza??o celular das prote?nas da via BER / 2020-01-01

Made available in DSpace on 2014-12-17T14:53:00Z (GMT). No. of bitstreams: 1 JeanneSSL_DISSERT.pdf: 3072042 bytes, checksum: 04de68fe169b7cc85a462e0690b00058 (MD5) Previous issue date: 2010-12-22 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / Increased competition in the market of urban transport, characteristic of the Brazilian cities from years 90, has required actions of the managing agencies to ensure the universality of service, enhancing efficiency and consumer welfare. It grows in the Brazilian municipalities, the need to adopt a systematic performance evaluation in terms of management system of indicators and targets appropriate to the regulatory context, which has the purpose of evaluating the accomplishment and compliance by dealers, of the services granted during the contract period, marked by increasingly long periods. The introduction of an index operational performance in permission contracts/concession in urban buses is intended to establish a regulatory performance, giving the contract a pro-competitive feature and to allow the managing agency the systematic and continuous monitoring of the performance of the delegated service to avoid major deviations from desired performance. A performance assessment model of public transportation companies by bus, and applicable to the case of Natal is proposed. Sought to add the particularities found in the transport system in order to assess the performance of enterprises, contribute to improving the service quality to the population and enable decision-makers a detailed knowledge of the behavior of the licensees / O aumento da competi??o no mercado de transporte urbano, caracter?stica das cidades brasileiras a partir dos anos 90, tem exigido a??es dos ?rg?os gestores para garantia da universaliza??o dos servi?os, do incremento da efici?ncia e bem-estar dos consumidores. Cresce nos munic?pios brasileiros, a necessidade de se adotar uma sistem?tica de avalia??o de desempenho em termos de gest?o de um sistema de indicadores e metas adequado ao contexto regulat?rio, que tenha a finalidade de avaliar a realiza??o e o cumprimento, por parte dos concession?rios, dos servi?os concedidos, durante a vig?ncia do contrato, pautado por prazos cada vez mais longos. A introdu??o de um ?ndice de desempenho operacional nos contratos de permiss?o/concess?o em ?nibus urbanos tem a finalidade de estabelecer uma regula??o de desempenho, dotando o contrato de uma fei??o pr?-competitiva e permitir ao organismo gestor o acompanhamento sistem?tico e cont?nuo da performance dos delegat?rios de modo a evitar desvios maiores de desempenhos almejados. Prop?e-se aqui um modelo de avalia??o de desempenho de empresas de transporte urbano por ?nibus, e aplic?vel ao caso de Natal. Buscou-se agregar as particularidades encontradas no sistema de transportes, de forma a aferir o desempenho das empresas, contribuir com a melhoria na qualidade do servi?o prestado ? popula??o e permitir aos decisores um conhecimento detalhado do comportamento das concession?rias

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-03-20T22:05:11Z No. of bitstreams: 1 AnaMariliaDutraFerreiraDaSilva_DISSERT.pdf: 1631709 bytes, checksum: 8048f45711d3e952c4de4d6126b4f2c9 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-03-23T19:32:23Z (GMT) No. of bitstreams: 1 AnaMariliaDutraFerreiraDaSilva_DISSERT.pdf: 1631709 bytes, checksum: 8048f45711d3e952c4de4d6126b4f2c9 (MD5) / Made available in DSpace on 2017-03-23T19:32:23Z (GMT). No. of bitstreams: 1 AnaMariliaDutraFerreiraDaSilva_DISSERT.pdf: 1631709 bytes, checksum: 8048f45711d3e952c4de4d6126b4f2c9 (MD5) Previous issue date: 2016-08-09 / O trabalho apresenta um estudo sobre a participa??o democr?tica no ?mbito da regula??o ? luz do objetivo constitucional de promo??o do desenvolvimento. Constata-se que a regula??o visa o cumprimento dos direitos fundamentais e a observ?ncia da democracia, da justi?a social, da liberdade e da dignidade da pessoa humana. A partir disso, pretende analisar a participa??o da sociedade civil na esfera regulat?ria como um dos fundamentos constitucionais para o desenvolvimento do pa?s. Para tanto, relaciona a estrutura institucional de uma na??o com o seu potencial de crescimento econ?mico e desenvolvimento, estabelecendo o conte?do jur?dico deste. Argumenta, a partir da doutrina e da hermen?utica constitucional, que a concep??o de desenvolvimento n?o se restringe a par?metros econ?micos, devendo-se considerar aspectos sociais e ambientais. Compreende que a democracia participativa ? elemento intr?nseco e instrumental do desenvolvimento. Verifica, como corol?rio, que os interesses essenciais ao desenvolvimento - mas que podem apresentar-se de maneira conflitante - devem ser sopesados no ?mbito da regula??o, a partir de uma racionalidade procedimental participativa. Visa, ainda, identificar qual o lastro constitucional a partir do qual se justifica a democratiza??o da Administra??o P?blica. Relaciona a reforma estatal - concebida em termos de descentraliza??o, consensualismo e horizontaliza??o das rela??es entre Administra??o P?blica e administrados - com uma nova perspectiva de encarar-se o interesse p?blico e o princ?pio da efici?ncia. Averigua, por fim, a participa??o da sociedade civil no ?mbito da regula??o de recursos h?dricos, notadamente na estrutura da Ag?ncia Nacional de ?guas e no caso do Comit? de Bacia Hidrogr?fica Pianc?-Piranhas-A?u. Faz-se uso do m?todo dedutivo e da pesquisa bibliogr?fica, al?m do exame dos relat?rios das audi?ncias/consultas p?blicas realizadas pela Ag?ncia Nacional de ?guas e das atas das reuni?es ordin?rias e extraordin?rias promovidas pelo Comit? de Bacia Hidrogr?fica Pianc?-Piranhas-A?u. Conclui-se que a participa??o da sociedade civil na Administra??o P?blica encontra fundamento na Constitui??o Federal. Ademais, no ?mbito da regula??o de recursos h?dricos, verifica-se que n?o se trata de uma utopia ou de um mero instrumento de ret?rica, apresentando-se muitas das vezes de forma eficiente e efetiva. No entanto, explica que ajustes devem ser feitos, a fim de solucionar alguns problemas identificados e otimizar a atua??o administrativa com vias ? consecu??o do desenvolvimento nacional. / The work presents a study on democratic participation in the scope of regulation in the light of the constitutional goal of promoting development. It is noted that the regulation aims to implement basic rights and observance of democracy, social justice, freedom and human dignity. From that, one intends to analyze the participation of civil society in the regulatory sphere as one of the constitutional foundations for the development of the country. Therefore, it relates the institutional structure of a nation with its potential for economic growth and development, establishing the legal contents of such. It argues, from the doctrine and constitutional hermeneutics, that the concept of development is not restricted to economic parameters and should consider social and environmental aspects. It understands that participatory democracy is an intrinsic and instrumental element of development. It verifies, as a corollary, that the essential interests to development - but that may be presented in a conflicting way - must be weighed in the context of regulation, from a participatory procedural rationality. It also aims to identify the constitutional ballast from which the democratization of Public Administration is justified. It relates the state reform - conceived in terms of decentralization, consensualism and horizontality of relations between Public Administration and administered people - with a new perspective of looking up the public interest and the principle of efficiency. It finally ascertains the participation of civil society in the regulation of water resources, especially in the structure of the National Water Agency-ANA and in the case of the Watershed Committee Pianc?-Piranhas-A?u. It makes use of the deductive method and literature review, as well as examines reports of the audiences/public consultations conducted by the National Water Agency and the minutes of both ordinary and extraordinary promoted by the Watershed Committee Pianc?-Piranhas-A?u. One concludes that the participation of civil society in Public Administration is one of the foundations of the Federal Constitution. Moreover, in the context of regulation of water resources, it appears that this is not a utopia or a mere rhetorical instrument, performing often efficiently and effectively. However, it explains that adjustments should be made in order to solve some problems identified and optimize administrative operations with means to the attainment of national development.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-03-21T00:24:48Z No. of bitstreams: 1 CamilaDeCarvalhoGomes_DISSERT.pdf: 580845 bytes, checksum: c4711c562aa7338ecab71f7585d2841c (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-03-27T19:37:41Z (GMT) No. of bitstreams: 1 CamilaDeCarvalhoGomes_DISSERT.pdf: 580845 bytes, checksum: c4711c562aa7338ecab71f7585d2841c (MD5) / Made available in DSpace on 2017-03-27T19:37:41Z (GMT). No. of bitstreams: 1 CamilaDeCarvalhoGomes_DISSERT.pdf: 580845 bytes, checksum: c4711c562aa7338ecab71f7585d2841c (MD5) Previous issue date: 2016-11-10 / O c?ncer corresponde a um grupo de v?rias doen?as que t?m em comum a prolifera??o descontrolada de c?lulas anormais e que pode ocorrer em qualquer local do organismo. Os tumores mais frequentes na inf?ncia e na adolesc?ncia s?o as Leucemias, e a Leucemia Linfobl?stica Aguda (LLA) ? a mais prevalente. A desnutri??o evidenciada nesses pacientes est? relacionada ? s?ndrome da anorexiacaquexia desencadeada pela doen?a, mas tamb?m nas altera??es do apetite, que ocorrem durante o tratamento quimioter?pico e interferem no estado nutricional bem como na resposta a terapia antineopl?sica. Embora seja reconhecida a poss?vel influ?ncia dos horm?nios relacionados ao apetite sobre as altera??es no consumo alimentar de pacientes com LLA durante o tratamento quimioter?pico, poucos estudos na literatura investigaram as altera??es hormonais em pacientes com c?ncer infantojuvenil. Diante disso, o objetivo desse estudo foi avaliar o estado nutricional e os n?veis dos principais horm?nios relacionados ao apetite em crian?as e adolescentes portadoras de LLA na fase de indu??o do tratamento quimioter?pico. Para atingir o objetivo, foram acompanhadas 14 crian?as ou adolescentes com o diagn?stico de LLA durante os 28 dias do ciclo de indu??o do tratamento quimioter?pico. No momento basal (antes do in?cio da quimioterapia), na metade e ao final desse ciclo foram realizadas avalia??es de estado nutricional antropom?trico, do consumo alimentar e diet?tico sob a forma de registro alimentar pesado, e dos marcadores bioqu?micos e hormonais. Foram avaliados os seguintes horm?nios relacionados ao apetite: leptina, grelina, insulina e cortisol. A maioria dos pacientes apresentava eutrofia no in?cio do tratamento, e este diagn?stico n?o foi alterado de forma significativa durante o ciclo de indu??o. O consumo alimentar e diet?tico apresentou um aumento ao longo do ciclo, especialmente em rela??o ao consumo de prote?nas e lip?deos do in?cio at? o final do tratamento. Em rela??o aos par?metros bioqu?micos, observou-se aumento significativo nos par?metros das plaquetas e na transaminase glut?mica pir?vica, assim como redu??o significativa nas concentra??es de glicemia, creatinina e o s?dio. Sobre os horm?nios relacionados ao apetite, registrou-se altera??o estatisticamente significativa apenas na concentra??o de grelina, que apresentou um aumento entre os momentos basal e meio do ciclo (p=0,027), mas n?o do meio para o final do ciclo. Em conclus?o, o per?odo de indu??o do tratamento da LLA provocou um aumento no consumo de energia e nutrientes, assim como um aumento na concentra??o de grelina, mas sem repercuss?o sobre o estado antropom?trico dos pacientes ou nos outros horm?nios relacionados ao apetite. / Cancer is a group of several diseases that have in common an uncontrolled proliferation of abnormal cells, and it can occur at anywhere in the body. The most frequent tumors in childhood and adolescence are the leukemias, and the Acute Lymphoblastic Leukemia (ALL) is the most prevalent. The evidenced malnutrition in these patients is related to anorexia-cachexia syndrome triggered by the disease, but also on changes in appetite, which occur during chemotherapy and interfere in the nutritional status as well as in response to antineoplasic therapy. Although it recognized a possible influence of hormones related to appetite on the changes in food consumption of ALL patients during chemotherapy, few studies have investigated the hormonal changes in patients with childhood cancers. Thus, the aim of this study was to evaluate the nutritional status and levels of key hormones related to appetite in children and adolescents with Acute Lymphoblastic Leukemia (ALL) in the induction phase of chemotherapy. For this purpose, it was assessed 14 children/adolescents diagnosed with ALL during the 28 days of induction chemotherapy cycle. At baseline (prior to initiation of chemotherapy), in the middle and at the end of this cycle were performed anthropometric measurement, weighted food record 24 hours and biochemical and hormone levels were obtained. It were evaluated the following hormones related to appetite: leptin, ghrelin, insulin and cortisol. Most patients had normal weight at the beginning of treatment which did not change significantly during the induction cycle. The dietary intake increased over the cycle, particularly in relation to proteins and lipids intake from the beginning to the end of treatment. Platelet levels and transaminase glutamic pyruvic significantly increased, and a significant reduction in blood glucose, creatinine and sodium levels were observed. Regarding appetite hormones, ghrelin significantly increased between the baseline and the half of the cycle (p = 0.027), but not through the end. In conclusion, the ALL treatment induction period caused an increase in energy and nutrients intake, as well as an increase in the concentration of ghrelin, but no impact on the anthropometric status of patients or in other hormones related to appetite.

Made available in DSpace on 2016-04-04T18:29:40Z (GMT). No. of bitstreams: 1 BERENICE VICTOR CARNEIRO.pdf: 3590625 bytes, checksum: c12256d2735ce90af0df41e15e96a213 (MD5) Previous issue date: 2008-02-15 / The aim of this study was to analyze psychometric properties of the Brazilian version of the Observer Alexithymia Scale (OAS) by estimating its internal consistency, test-retest reliability and inter-rater reliability; construct validity through factorial analysis, criteria validity and convergent validity in a clinical population with substance dependence or abuse. The OAS is a brief observer report designed to be used by clinicians as well as patient s relatives and acquaintances, to identify Alexithymia according to 5 dimensions: distant, uninsightful, somatizing, humorless, and rigid. It is composed of 33 items rated on a 4-point Likert scale, ranging from 0 (never, not at all like the person) to 3 (all of the time, completely like the person). Data were gathered at an outpatient public service for substance dependence and a non-profit religious inpatient institution also for substance dependence. The sample was comprised of three groups: G1 - 200 relatives or acquaintances of substance dependence and abusers (alcohol=46.5%; drugs=53.5 %), aged from 18 to 82 (M = 48, SD = 12), both sexes (F=88%; M=12%); G2 39 outpatients at the public service for substance dependence or abuse (alcohol=66,6%; drugs=33,3%), both sexes (F=15.3%; M=84.6%); G3 9 clinicians at the public service (clinical experience ranging from 1-15 years). Reliability studies suggested good internal consistency and temporal stability of the scale for both G1 (alpha = .83; rs = .79) and G3 (alpha= .85; rs= .80), but low inter-rater reliability when scored by relatives and clinicians (rs = .14). The OAS s exploratory factor analysis suggested a structure of 5 dimensions (48% total variance) as the original one, and 30 items with a minimum factor loadings of .40. When the degree of alexithymia was estimated as a criteria, the study indicated that relatives do not view those with substance dependence differently (p = 0.16) according to type of dependence (alcohol or drugs). For the convergent study, G2 participants completed the Toronto Alexithymia Scale (TAS) and the scores were compared against OAS-30, according to G1 and G3. Results suggested a negligible association (rs = .29; p >0.05) between TAS-22 and OAS, according to G1 and a lack of association (rs = -.18; p >0.20) between TAS-22 and OAS-30 scored by G3, suggesting that both scales would be measuring different constructs. The Portuguese version of the OAS-30 demonstrated good internal consistency and temporal stability. Its structure seems to be compatible to the original one, but a few items need revision, especially on factor 4. Some considerations will be made regarding the educational level of respondents, as well as the degree of acquaintance with the person who is substance dependent. / O estudo analisou propriedades psicom?tricas da vers?o brasileira da Observer Alexithymia Scale (OAS). Foram estimadas, a consist?ncia interna, precis?o por testereteste e precis?o entre avaliadores; validade de construto por meio de an?lise da estrutura fatorial, validade de crit?rio e validade convergente, em popula??o cl?nica por abuso ou depend?ncia de sust?ncias psicoativas. A OAS ? uma escala breve para uso do profissional cl?nico assim como pessoas que conhecem bem o paciente, para diagnosticar alexitimia segundo cinco dimens?es: distanciamento, sem insight, somatiza??o, sem gra?a e rigidez. ? composta de 33 itens que devem ser respondidos atrav?s de uma escala Likert de 4 pontos, sendo o grau de intensidade indicado pela escolha entre 0 (nunca, em nada parecido) e 3 (todo o tempo, totalmente parecido). Os dados foram coletados em servi?o p?blico ambulatorial para dependentes de subst?ncia e uma institui??o sem fins lucrativos, com v?nculo religioso, para o tratamento residencial da depend?ncia de subst?ncia. A amostra foi composta de tr?s grupos: G1 200 familiares ou amigos (F=88%; M=12%) de dependentes ou que abusam de subst?ncia (?lcool=46,5% e drogas=53,5%); G2 39 dependentes de subst?ncia (?lcool=66,6%; drogas=33,3%), ambos os sexos (F=15,3%; M=84,6%) em tratamento no servi?o ambulatorial e G3 nove terapeutas do servi?o ambulatorial com experi?ncia cl?nica entre 1 e 15 anos. Os estudos de consist?ncia interna e precis?o indicaram que a OAS possui boa consist?ncia interna, tanto entre os participantes do G1 (alfa = 0,83) quanto do G3 (alfa = 0,85) e boa estabilidade temporal (rs = 0,79; rs = 0,80), mas baixa precis?o entre avaliadores quando avaliada por familiares e profissionais (rs = 0,14). A an?lise fatorial explorat?ria indicou uma estrutura com 5 dimens?es (vari?ncia total = 48%) e 30 itens com cargas fatoriais m?nimas de 0,40, reproduzindo a estrutura da escala original. Na validade de crit?rio, o grau de alexitimia foi estudado em fun??o do tipo de depend?ncia (?lcool ou drogas qu?micas), tomado como medida de crit?rio. N?o se observou rela??o entre o tipo de depend?ncia e alexitimia avaliada pela OAS-30 (p = 0,16). Para o estudo de validade convergente, os participantes do G2 completaram a Escala de Alexitimia de Toronto (TAS-22). Os resultados sugerem muito baixa associa??o entre os escores da TAS-22 e a OAS-30 avaliada pelo G1 (rs = 0,29; p >0,05) e entre a TAS-22 e a OAS-30, completada pelo G3 (rs = -0,18; p >0,20), indicando que as escalas estariam medindo diferentes construtos. Os resultados apontam que a OAS-30 det?m boa precis?o e que a estrutura fatorial ? compat?vel com a vers?o original. No entanto, h? necessidade de revis?o de alguns itens, especialmente no Fator 4. Considera??es a respeito da influ?ncia do n?vel de escolaridade do respondente, assim como o n?vel de familiaridade do respondente com o dependente de subst?ncia psicoativa s?o realizadas.

Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2017-10-30T18:18:54Z No. of bitstreams: 1 2016 - Lilyan Guimar?es Berlim.pdf: 8659835 bytes, checksum: 7c1a0bff7a0ddc1e839d674f71b6cc82 (MD5) / Made available in DSpace on 2017-10-30T18:18:54Z (GMT). No. of bitstreams: 1 2016 - Lilyan Guimar?es Berlim.pdf: 8659835 bytes, checksum: 7c1a0bff7a0ddc1e839d674f71b6cc82 (MD5) Previous issue date: 2016-09-30 / CAPES / The fashion and textile industry is one of the largest business segment in the world. However, this segment has been the subject of ethics, aesthetics and environmental criticism, especially so-called "fast fashion", a high-speed production system, integrated with information technology, which manages releases, sales, inventory and manufacturing clothes, turning datasheets of garments in a finished product within points of sale in a few days. The fast fashion phemomenon settled in the fashion industry in the last decades of the twentieth century as a result of the dynamics of global capitalism in search of lower cost and reduced production, time, space, distribution and sale. The fast fashion, however, has been socially criticised as it?s based on precarious work and promoting hyper consumption which leads to quick disposal of clothing, consumption of natural resources at breakneck scale and also the standardization of the body and spread a subtle homogenization of the appearance, promoted by the fashion media. The research has mapped and analysed the relationship between fashion and social criticism, with emphasis on appearance, construction and current settings of the ethical criticism and aesthetics to fast fashion. It has also mapped and analysed some answers that the market has given to such criticism, as well as alternative proposals built by various social groups, in particular the slow fashion movement: its concept, ideas and production proposals, consumption and engagement. From the politicization of consumption and macro trends that are configured as a socio-cultural background of the fashion consumption trends, we see the various forms of expression of these criticisms and seek to understand its incorporation into the market. For this, we rely on the theoretical framework of Boltanski and Chiapello (2009), which considers the incorporation of criticism as necessary to the moral justification of capitalism and its maintenance. The results indicate that the criticisms are expressed and are incorporated by fashion design professional, in consumption practices. in the pursuit of sustainable business forms, creating value associated with the shared economy, the adoption of Corporate Social Responsibility, in changes in production processes and the use of lower-impact materials. We also verified that as a way of incorporating criticism as a counterpoint to the hegemonic practices of production and consumption, the movement "slow fashion" proposes not only deceleration time of production and consumption of clothes, but also empowerment and political activism in the area of fashion design. In conclusion, the research identified as a response to criticism, the existence of changes in the sector and the growing ethicization fashion. / A moda e a ind?stria t?xtil constituem um dos maiores segmentos de neg?cios do mundo. Associadas simbioticamente, chamamos este campo de ind?stria da moda. O segmento vem sendo alvo de cr?ticas ?ticas, est?ticas e ambientais. Estas cr?ticas se dirigem, principalmente, ao que tem sido chamado de ?moda r?pida?, ou fast fashion, um sistema de produ??o de alta velocidade, integrado ?s tecnologias de informa??o, que gerencia lan?amentos, vendas, estoques e manufatura de roupas, transformando fichas t?cnicas de pe?as de vestu?rio em um produto acabado dentro de pontos de venda em poucos dias. O fast fashion ? uma consequ?ncia das din?micas do capitalismo global em busca do menor custo, em um menor espa?o de tempo de fabrica??o, distribui??o e venda, baseando-se em trabalho prec?rio (muitas vezes em condi??es an?logas ? escravid?o), na promo??o do hiperconsumo e do descarte r?pido de roupas e, consequentemente, do consumo de recursos naturais em escala vertiginosa, com impactos ambientais de grande extens?o, e, ainda, na padroniza??o do corpo e na difus?o de uma sutil homogeneiza??o do parecer, promovida pelas m?dias de moda. Tais pr?ticas se estabeleceram na moda nas ?ltimas d?cadas do s?culo XX como consequ?ncia das transforma??es do capitalismo global. A presente pesquisa mapeou e analisou as rela??es entre a moda e a cr?tica, o surgimento, a constru??o e as atuais configura??es da cr?tica ?tica e est?tica ao fast fashion e as respostas que o mercado vem dando ?s mesmas, assim como as propostas alternativas constru?das por segmentos do mercado, em especial, o movimento ?moda lenta?, ou slow fashion: seu conceito, ideias e propostas de produ??o, consumo e engajamento. A partir da an?lise da politiza??o do consumo e das macrotend?ncias, que se configuram como um pano de fundo sociocultural ?s tend?ncias de consumo, verificamos a express?o destas cr?ticas e sua incorpora??o pelo corpo social; identificamos a? uma chave explicativa para a incorpora??o das cr?ticas pelo mercado de moda, corroborando com o quadro te?rico de Boltanski e Chiapello (2009), que entende a incorpora??o das cr?ticas como necess?ria ? justifica??o moral do capitalismo e sua manuten??o. Os resultados indicaram que tanto o corpo social quanto o mercado expressam e incorporam as cr?ticas nas pr?ticas de consumo de moda; na busca por formas de novos neg?cios sustent?veis; na cria??o de valor associado ? economia compartilhada; na ado??o da Responsabilidade Socioambiental Empresarial e da ?tica nos neg?cios; nas altera??es em processos produtivos; e no uso de mat?rias primas menos impactante. Verificamos tamb?m que, como incorpora??o das cr?ticas e como contraponto ?s pr?ticas hegem?nicas de produ??o e consumo, o movimento slow fashion prop?e n?o apenas a desacelera??o do tempo de produ??o e consumo de roupas, mas tamb?m um empoderamento e ativismo pol?tico na ?rea do design de moda, tanto na produ??o quanto no consumo. A pesquisa identificou a exist?ncia de altera??es no setor em fun??o da incorpora??o das cr?ticas, em especial a crescente eticiza??o da moda.