This research proposes a new dynamic energy management framework for a backbone Internet Protocol over Dense Wavelength Division Multiplexing (IP over DWDM) network. Maintaining the logical IP-layer topology is a key constraint of our architecture whilst saving energy by infrastructure sleeping and virtual router migration. The traffic demand in a Tier 2/3 network typically has a regular diurnal pattern based on people‟s activities, which is high in working hours and much lighter during hours associated with sleep. When the traffic demand is light, virtual router instances can be consolidated to a smaller set of physical platforms and the unneeded physical platforms can be put to sleep to save energy. As the traffic demand increases the sleeping physical platforms can be re-awoken in order to host virtual router instances and so maintain quality of service. Since the IP-layer topology remains unchanged throughout virtual router migration in our framework, there is no network disruption or discontinuities when the physical platforms enter or leave hibernation. However, this migration places extra demands on the optical layer as additional connections are needed to preserve the logical IP-layer topology whilst forwarding traffic to the new virtual router location. Consequently, dynamic optical connection management is needed for the new framework. Two important issues are considered in the framework, i.e. when to trigger the virtual router migration and where to move virtual router instances to? For the first issue, a reactive mechanism is used to trigger the virtual router migration by monitoring the network state. Then, a new evolutionary-based algorithm called VRM_MOEA is proposed for solving the destination physical platform selection problem, which chooses the appropriate location of virtual router instances as traffic demand varies. A novel hybrid simulation platform is developed to measure the performance of new framework, which is able to capture the functionality of the optical layer, the IP layer data-path and the IP/optical control plane. Simulation results show that the performance of network energy saving depends on many factors, such as network topology, quiet and busy thresholds, and traffic load; however, savings of around 30% are possible with typical medium-sized network topologies.

Sleeping sickness, caused by Trypanosoma brucei, is a deadly disease that affects some of the poorest countries in sub-Saharan Africa. Although the disease prevalence is declining, strengthening of the current control efforts, including introduction of more adequate chemotherapeutic options, is needed to prevent the re-emergence of yet another epidemic. Nitroaromatic compounds, such as nifurtimox (in combination with eflornithine) and fexinidazole (in clinical trials), have been recently introduced for the treatment of the second stage of sleeping sickness. These compounds are believed to act as pro-drugs that require intracellular enzymatic activation for antimicrobial activity. Here, the role of the bacterial-like nitroreductase TbNTR as a nitrodrug activating enzyme is examined through overexpression and knock-out studies in T. brucei. Multiple attempts to purify soluble recombinant TbNTR from E. coli were unsuccessful, because the recombinant protein was found to be membrane associated. In keeping with the role of TbNTR in nitrodrug activation, loss of an NTR gene copy in T. brucei was found to be one, but not the only, mechanism that may lead to nitrodrug resistance. Furthermore, in the bloodstream form of T. brucei, resistance was relatively easy to select for nifurtimox, with no concurrent loss of virulence and at clinically relevant levels. More worryingly, nifurtimox resistance led to a decreased sensitivity of these parasites to other nitroaromatic compounds, including a high level of cross-resistance to fexinidazole. Conversely, generation of fexinidazole resistance resulted in cross-resistance to nifurtimox. Should these findings translate to the field, emerging nitrodrug resistance could reverse all recent advances in the treatment of sleeping sickness, made since the introduction of eflornithine 20 years ago. Therefore, all efforts should be made to ensure nitroaromatic drugs are used only in drug combination therapies against sleeping sickness, in order to protect them from emerging resistance.

<p>This study has emerged from a growing interest in students' sleeping habits. During practical training as teachers, we have noticed a discussion of students' sleeping habits, fatigue and student performance at school in relation to their sleeping habits. The purpose of this field survey was to examine students’ sleeping habits and self-perceived performance ability in school in relation to sleeping habits. The material was collected from a questionnaire that was answered by 200 students in 4-6^th grade and 188 students in 1-2th grade in the upper secondary school, this to give an opportunity to see if there were any differences between the different age groups. Differences in gender have also been looked into. The results of the study show that many students, regardless of age or gender, that are sleeping less than 8 hours on school-nights also are tired in school and not able to fully concentrate during the day. The results show some correlation between sleeping habits and how the students feel they are able to perform in school. The results also show that older students sleep less than the younger ones, but a bigger part of the younger students than the older seem to have problems concentrating in school. The results also show a tendency towards differences in sleeping habits between genders, regardless of age, where boys sleep less than girls, but girls have a harder time concentrating in school.</p>

This study has emerged from a growing interest in students' sleeping habits. During practical training as teachers, we have noticed a discussion of students' sleeping habits, fatigue and student performance at school in relation to their sleeping habits. The purpose of this field survey was to examine students’ sleeping habits and self-perceived performance ability in school in relation to sleeping habits. The material was collected from a questionnaire that was answered by 200 students in 4-6th grade and 188 students in 1-2th grade in the upper secondary school, this to give an opportunity to see if there were any differences between the different age groups. Differences in gender have also been looked into. The results of the study show that many students, regardless of age or gender, that are sleeping less than 8 hours on school-nights also are tired in school and not able to fully concentrate during the day. The results show some correlation between sleeping habits and how the students feel they are able to perform in school. The results also show that older students sleep less than the younger ones, but a bigger part of the younger students than the older seem to have problems concentrating in school. The results also show a tendency towards differences in sleeping habits between genders, regardless of age, where boys sleep less than girls, but girls have a harder time concentrating in school.

A class of linear diamidines was synthesized for the evaluation as a treatment of Human African Trypanosomiasis. These fused heterocyclic compounds are thiazole[5,4-d]thiazoles and are of interest because the parent compound, 2,5-Bis(4-amidinophenyl)-thiazolo[5,4-d]thiazole HCl salt, which is also called DB 1929, has exhibited a low nanomolar IC50 value against Trypanosoma brucei rhodesiense and has shown selectivity for binding to the human telomere G-quadruplex over that of DNA duplex. A fluoro and a methoxy derivative have been synthesized and are currently undergoing testing for activity and binding affinity. In addition, fluorescence studies of selected diamidines were done to study the effect of structural variation on fluorescence. This data is useful since it can determine what types of moieties are needed to yield a compound that will fluoresce in the higher wavelengths (500 nm and above) of the visible spectrum, which would be advantageous in determining the uptake of the drug in the trypanosome within the endemic areas of Africa with a simple microscope.

The Grimm Brothers’ Little Briar-Rose is a beloved fairytale, which is more commonly known as Sleeping Beauty. What began as a Volksmärchen, is now a world famous and beloved Kunstmärchen. The Brothers collected and adapted the tale, incorporating their own literary style, helping to develop a literary Germanic cultural history. In this thesis I analyze how the tale evolves from the original oral tale to the literary story, and how various perspectives of culture and authors, with particular audiences in mind, adapt their versions. Historical background of the Grimms and their influences, an analysis of how the story was revised by the Grimms in the 1812 and 1857 editions, how American children’s versions compare to the Grimms’ version and how Jane Yolen’s version of Sleeping Beauty meets the structural and cultural expectations of the Grimms’ tale are examined.

This was an applied ethnographic study of natural and cultural resources of contemporary significance for American Ojibway' tribes and Canadian Ojibway First Nations that are or were once present within or in the immediate vicinity of four National Park Service (NPS) units in the Midwest Region: Sleeping Bear Dunes National Lakeshore (SLBE), Michigan; Pictured Rocks National Lakeshore (PIRO), Michigan; Apostle Islands National Lakeshore (APIS), Wisconsin; and Voyageurs National Park (VOYA), Minnesota. The main objective of this study, according to the Scope of Work (SOW) of 1996, was to develop a documented basis of knowledge regarding historic and current use of resources by culturally affiliated Native American tribes that should help park managers anticipate Native American resource use issues that may confront them in the future and thus be better prepared to deal with them in an informed and culturally sensitive manner. The study also was to provide recommendations regarding preservation, monitoring, mitigation, interpretation, and use access issues. The research was designed to provide a historical and ethnographic overview and assessment of Native American, Southwestern Ojibway in particular, land and resource use as it pertains to the region where the parks are located, and to each park unit. This study also provided an inventory of ethnographic resources known to have been significant for culturally affiliated Southwestern Ojibway tribes at different points in time.

Fifth Generation (5G) cellular networks will experience a thousand-fold increase in data traffic with over 100 billion connected devices by 2020. In order to support this skyrocketing traffic demand, smaller base stations (BSs) are deployed to increase capacity. However, more BSs increase energy consumption which contributes to operational expenditure (OPEX) and CO2 emissions. Also, an introduction of a plethora of 5G applications running in the mobile devices cause a significant amount of energy consumption in the mobile devices. This thesis presents a novel framework for energy efficiency in 5G cloud radio access networks (C-RAN) by leveraging cloud computing technology. Energy efficiency is achieved in three ways; (i) at the radio side of H-C-RAN (Heterogeneous C-RAN), a dynamic BS switching off algorithm is proposed to minimise energy consumption while maintaining Quality of Service (QoS), (ii) in the BS cloud, baseband workload consolidation schemes are proposed based on simulated annealing and genetic algorithms to minimise energy consumption in the cloud, where also advanced fuzzy based admission control with pre-emption is implemented to improve QoS and resource utilisation (iii) at the mobile device side, Mobile Edge Computing (MEC) is used where computer intensive tasks from the mobile device are executed in the MEC server in the cloud. The simulation results show that the proposed framework effectively reduced energy consumption by up to 48% within RAN and 57% in the mobile devices, and improved network energy efficiency by a factor of 10, network throughput by a factor of 2.7 and resource utilisation by 54% while maintaining QoS.

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