This thesis examines the relationship of verbal intelligence and social cognition through verbal subtests of Wechsler intelligence scales for adults (3rd revision) and Differential Self and Complexity of representations of People and Understanding of Social Causality scales in Thematic Apercepčního Test. The theoretical part introduces the concepts of intelligence and social cognition, as well as psychological tests of intelligence tests and apperception techniques. The theoretical part also focuses on the social intelligence as an answer to the question of the relationship between intelligence and social cognition. In the empirical part of the thesis data collected from 30 probands is processed who underwent testing above mentioned psychological tests. The data are processed with correlation and factor analysis. The conclusions statistical processing are in the thesis further developed in the context of the theoretical base of scientific knowledge. The discussion points to limits of the testing and suggests options for the future researchs.

Humans are unique in their ability to flexibly and rapidly adapt their behaviour and select courses of action that lead to future reward. Several ‘component processes’ must be implemented by the human brain in order to facilitate this behaviour. This thesis examines two such components; (i) the neural substrates supporting action selection during value- guided choice using magnetoencephalography (MEG), and (ii) learning the value of environmental stimuli and other people’s actions using functional magnetic resonance imaging (fMRI). In both situations, it is helpful to formally model the underlying component process, as this generates predictions of trial-to-trial variability in the signal from a brain region involved in its implementation. In the case of value-guided action selection, a biophysically realistic implementation of a drift diffusion model is used. Using this model, it is predicted that there are specific times and frequency bands at which correlates of value are seen. Firstly, there are correlates of the overall value of the two presented options, and secondly the difference in value between the options. Both correlates should be observed in the local field potential, which is closely related to the signal measured using MEG. Importantly, the content of these predictions is quite distinct from the function of the model circuit, which is to transform inputs relating to the value of each option into a categorical decision. In the case of social learning, the same reinforcement learning model is used to track both the value of two stimuli that the subject can choose between, and the advice of a confederate who is playing alongside them. As the confederate advice is actually delivered by a computer, it is possible to keep prediction error and learning rate terms for stimuli and advice orthogonal to one another, and so look for neural correlates of both social and non-social learning in the same fMRI data. Correlates of intentional inference are found in a network of brain regions previously implicated in social cognition, notably the dorsomedial prefrontal cortex, the right temporoparietal junction, and the anterior cingulate gyrus.

Les difficultés à interagir dans le monde social et à s’y adapter sont une plainte centrale des personnes souffrant de troubles psychiatriques et notamment de schizophrénie ou de troubles apparentés. Ces difficultés, qui constituent un frein au processus de réhabilitation psychosociale, pourraient en partie être expliquées par un dysfonctionnement des processus regroupés sous le terme de cognition sociale. La cognition sociale est définie comme la capacité à construire des représentations sur soi-même et autrui, et sur les relations entre soi et les autres, ainsi qu’à utiliser ces représentations de manière flexible, afin de guider le comportement social ; et inclut des processus tels que le traitement des émotions, la théorie de l’esprit, le style attributionnel, la perception et les connaissances sociales. Des déficits concernant les différentes composantes de la cognition sociale ont été largement mis en évidence dans la schizophrénie et les troubles apparentés, et semblent par ailleurs avoir un lien fort avec les difficultés observées dans les domaines du fonctionnement social, mais également des relations privilégiées avec les processus neurocognitifs, même si ces deux composantes semblent relativement indépendantes. Afin de compenser ces troubles, de nombreuses prises en charge de remédiation cognitive ont été proposées ces dernières années. L’objectif de ce travail de thèse a été d’évaluer la possibilité d’améliorer les déficits touchant la sphère de la cognition sociale des personnes souffrant de troubles psychotiques à l’aide d’un outil de remédiation spécifiquement développé à cet effet, le programme RC2S. Etant donnée l’hétérogénéité des déficits touchant la sphère de la cognition sociale dans la schizophrénie, et l’importance fondamentale portée au transfert des compétences dans la vie quotidienne, RC2S a été développé comme une thérapie individualisée et flexible, qui permet aux patients de s’entraîner aux interactions sociales dans un environnement réaliste, et d’adapter la prise en charge aux difficultés spécifiques de la personne. Nous présenterons ici trois études basées sur la méthodologie du cas unique, mettant en évidence l’impact de cette thérapie sur les troubles de la cognition sociale de deux patients souffrant de schizophrénie et d’un patient présentant un trouble de la personnalité schizoïde. / In people with psychiatric disorders, particularly those suffering from schizophrenia and related illnesses, pronounced difficulties in social interactions and adaptation are a key manifestation. These disabilities, which are a serious impediment to psychosocial rehabilitation process, could be partly explained by impairments in processes grouped under the generic term of social cognition. Social cognition is defined as the ability to construct mental representations about others and oneself, and about one’s relationships to others, and to use these representations in a flexible way to guide social behavior. It includes abilities such as emotion processes, theory of mind (ToM), attributional style, and social perception and knowledge. In schizophrenia and related disorders, several components of social cognition are usually altered, and are strongly associated with functional outcome and independent but partly related to neurocognitive processes. The impact of several kinds of interventions and particularly of social cognitive remediation programs has been studied recently, and new strategies and programs in this line are currently being developed. The main objective of this doctoral thesis was to assess the feasibility of improving social cognition in people with psychotic disorders, using a cognitive remediation program specifically designed for this purpose, the RC2S program. Considering that the social cognitive deficits experienced by patients with schizophrenia are very diverse, and that the main objective of social cognitive remediation is to improve patient’s functioning in their social daily life, RC2S was developed as an individualized and flexible program, which allows patients to practice social interactions in a realistic environment, and to adapt therapy to the specificity of every patient’s profile. This manuscript present three single case studies, using specific methodology, to highlight the impact of this new therapy on social cognitive impairments of two people with schizophrenia and one patient with schizoid personality disorder.

La maladie de Huntington s’accompagne de troubles des conduites sociales perturbant les relations interindividuelles. L'objectif de ce travail de thèse était de mieux comprendre ces troubles sociaux en examinant les habiletés en cognition sociale de personnes porteuses de la mutation ou atteintes de cette maladie neurogénétique. La cognition sociale comprend notamment la reconnaissance des émotions d’autrui, les connaissances sociales et la théorie de l’esprit, soit la capacité à attribuer aux autres des états mentaux affectifs (sentiments) ou cognitifs (intentions,croyances). Nous avons étudié la cognition sociale à la phase présymptomatique et symptomatique de la maladie de Huntington à l’aide de tests neuropsychologiques et de la neuroimagerie morphologique et fonctionnelle. Ce travail a été réalisé dans le cadre d’une collaboration entre le centre national de référence pour les maladies neurogénétiques de l'adulte du CHU d’Angers et la plate-forme d’imagerie médicale Cyceron de Caen. Ce travail visait à mieux comprendre les perturbations en cognition sociale accompagnant la maladie de Huntington, leur évolution et leurs bases neurobiologiques afin d’améliorer notre compréhension des troubles du comportement accompagnant cette maladie. Nous espérons ainsi pouvoir mieux contribuer au diagnostic, au pronostic et à la prise en charge des personnes concernées par cette maladie. / Huntington's disease is accompanied by disturbances insocial behavior that disrupt inter-individual relationships.The aim of this thesis was to better understand these social disorders by examining the social cognition skills of people with the mutation or the neurogenic disease. Social cognition includes the recognition of the emotions of others, social knowledge and the theory of the mind, namely the ability to attribute to others emotional (feelings) or cognitive (intentions, beliefs) mental states. We studied social cognition in the presymptomatic and symptomatic phase of Huntington's disease using neuropsychological tests and morphological and functional neuroimaging. This work was carried out within the framework of a collaboration between the national center of reference for the neurogenic diseases of adults of the CHU of Angers and the platform of medical imaging Cyceron of Caen. This work aimed to better understand the social cognition disruptions accompanying Huntington's disease, their evolution and their neurobiological basis in order to improve our understanding of behavioral disorders accompanying this disease. We hope to be able to better contribute to the diagnosis, prognosis and care of those affected by this disease.

A Ansiedade de Performance Musical (APM) é considerada uma condição caracterizada por apreensão persistente e intensa diante da apresentação musical pública, desproporcional ao nível de aptidão, treino e preparo do músico. Os sintomas ocorrem em uma escala de gravidade contínua que em seu extremo afeta a aptidão musical devido a sintomas ao nível físico, comportamental e cognitivo, além de déficits no processamento cognitivo e cognição social, em especial na capacidade de reconhecimento de expressões faciais de emoção (REFE). Assim, intervenções que possam corrigir esses vieses com eficácia são necessárias. Nesse sentido, os objetivos dos estudos que compõem esta tese são: a) avaliar o REFE em músicos com diferentes níveis de APM; b) realizar uma revisão sistemática da literatura de forma a trazer evidências sobre os efeitos das substâncias ansiolíticas no REFE em indivíduos saudáveis; e c) conduzir um ensaio clínico, cross over, randomizado, duplo cego e controlado por placebo para testar o efeito da OCT em músicos com alto/baixo nível de APM no REFE, nos indicadores de humor/ansiedade e na cognição negativa. Método: Para se atender ao objetivo realizou-se um estudoobservacional, transversal, com 150 músicos de ambos os sexos, de diferentes estilos musicais, os quais realizaram uma tarefa de REFE, após serem classificados quanto aos níveis de APM.Para atender-se o segundo objetivo conduziu-se uma revisão sistemática da literatura seguindo-se as diretrizes do PRISMA e do Cochrane Handbook for SystematicReviewsofInterventions. Por fim, para alcançar o terceiro objetivo, 43 músicos do sexo masculino, de diferentes estilos musicais participaram de um ensaio clínico, randomizado, cross over, controlado por placebo, no qual testou-se a eficácia de 24UI de OCT intranasal. Resultados:Os resultados evidenciaram que os músicos com altos níveis de APM apresentam um prejuízo global no REFE, expresso, sobretudo pela dificuldade no reconhecimento adequado da emoção alegria, a qual está associada aos sinais de aprovação social. A revisão da literatura evidenciou que poucas substâncias foram testadas até momento, e que as alterações no REFE foram específicas e dependentes do mecanismo de ação da substância no sistema nervoso central, dose e forma de administração. O ensaio clínico apontou uma melhora no reconhecimento da emoção alegria,somente em músicos com altos níveis de APM, após o uso agudo da OCT. Conclusão:O REFE mostrou-se alterado de forma específica em músicos com altos níveis de APM, os quais podem ser corrigidos através do uso da OCT intranasal, a qual desponta como uma substância promissora para o uso clínico / Musical Performance Anxiety (MPA) is considered a condition characterized by persistent and intense apprehension in circumstances involving public musical presentation, disproportionate to the musician\'s aptitude level, training and preparation. The symptoms occur on a continuous severity scale that affects, at its extreme, the musical aptitude due to symptoms at the physical, behavioral and cognitive levels, as well as interfering with cognitive processing and social cognition, especially in the facial emotion recognition (FER) ability. Thus, interventions that can effectively correct these deviances are necessary. Therefore, the aims of the studies that compose this thesis are: a) to analyze the (FER) in musicians with different levels of MPA; b) to carry out a systematic review of the literature in order to present evidence about the effects of anxiolytic substances on FER in healthy individuals; c) to conduct a randomized, double-blind, placebo-controlled, cross-over clinical trial to test the OT effect on musicians with high/low MPA level in FER, mood/anxiety indicators and negative cognition. Methods: To achieve the first aim of this study, a cross-sectional, observational study was conducted with 150 musicians of both sexes, of different musical styles, who performed a FER task, after being classified according to the MPA levels. As for the second aim, a systematic literature review was carried out in accordance with the PRISMA guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. Finally, for the third aim, 43 male musicians of different musical styles have participated in a randomized, placebo-controlled, cross-over clinical trial in which the 24UI of intranasal OT efficiency was tested. Results: The results showed that musicians with high levels of MPA present a global impairment in FER, expressed mainly by the difficulty in the appropriate recognition of the emotion of joy, which is associated with signs of social approval. The review of the literature showed that few substances have been tested so far, and that the changes in FER were specific and dependent on the substance mechanism of action in the central nervous system, dose and form of administration. The clinical trial presented an improvement in the recognition of the emotion of joy, only in musicians with high levels of MPA, after the OT acute use. Conclusion: The FER was specifically altered in musicians with high levels of MPA, which can be corrected with the use of intranasal OT, which appears as a promising substance for clinical use

La cognition sociale, i.e. notre capacité à attribuer des états mentaux à autrui et à identifier ses émotions, est souvent perturbée dans certaines pathologies telles que le traumatisme crânien (TC). Cette capacité est traditionnellement évaluée à l’aide de tâches sous format « papier-crayon » n’impliquant pas le participant dans une situation d’interaction sociale. Pourtant, la cognition sociale est fondamentale dans nos interactions sociales car elle nous permet de comprendre le discours et le comportement d’autrui. Ainsi, dans ce travail de thèse, nous avons évalué les capacités d’attribution d’états mentaux et de reconnaissance émotionnelle de personnes ayant subi un TC à l’aide de tâches les impliquant activement dans une situation de communication (tâche de communication référentielle et tâche EViCog), ce qui n’a jamais été fait dans cette pathologie. La tâche EViCog (Evaluation de la cognition sociale en interaction virtuelle), créée pour cette étude, permet d’avoir des conversations audio-visuelles avec des humains virtuels, qui expriment des émotions et produisent du discours nécessitant d’inférer leurs états mentaux. Les résultats ont montré que les difficultés des personnes TC étaient encore plus importantes pour la tâche en situation d’interaction (tâche EViCog) par rapport à des tâches traditionnelles au format « papier-crayon ». Par ailleurs, en situation d’interaction, les performances de cognition sociale semblent dépendre en partie des capacités mnésiques (mémoire autobiographique et du contexte), ainsi que des fonctions exécutives, alors que pour les tâches traditionnelles, les performances ne seraient expliquées que par certaines capacités exécutives. / Social cognition, i.e. the ability to attribute mental states to others and to identify emotions, is often impaired in various pathologies, such as traumatic brain injury (TBI). This ability is traditionally assessed with “paper-and-pencil” tasks that do not involve the participant in a social interaction situation. However, social cognition is central in our daily social interactions, as it helps us understand others’ speech and behavior. Thus, in this study, we assessed mental state attribution and emotion recognition abilities of TBI participants, using tasks that involve the participant in a communication situation (referential communication task and EViCog task). The EViCog task (social cognition evaluation in virtual interaction), designed for this research, provides audio-visual conversations with virtual humans, which express emotions and produce speech requiring mental state inference. The results showed that the difficulties of the TBI participants were even more important for the task in interaction situation (EViCog task) compared to traditional tasks in paper-and-pencil format. Moreover, in interaction situation, social cognition performance seemed to rely on mnemonic abilities (autobiographical memory and context memory), and on executive functions, while for traditional tasks, performances were only explained by some executive abilities.

Depuis des siècles, plusieurs penseurs et scientifiques ont abordé la relation entre la coopération, le langage et la cognition sociale. Parmi eux, Trần Đức Thảo (1917-1993) mérite une mention spéciale. Le but de la recherche qui suit est de présenter au lecteur la réflexion philosophique de Thảo sur le langage humain et son évolution. Nous essaierons de tracer les grandes lignes de la théorie de Thảo sur les origines du langage dans ses Recherches sur l'origine du langage et de la conscience (1973) dans lesquelles il a essayé de trouver une synthèse entre philosophie, linguistique, psychologie et anthropologie physique. La découverte du marxisme-léninisme a conduit Thảo à proposer une approche matérialiste et dialectique au problème de la relation entre corps esprit. De cette façon, Thảo a proposé une sorte de tournant matérialiste et historique de la philosophie de la conscience de Husserl qui était au cœur de ses premiers intérêts philosophiques. La théorie de Thảo met en relief la nature sociale du langage et de la cognition, de sorte que l’évolution du langage est inextricablement liée aux relations sociales. Une telle conclusion reposait sur l’hypothèse que le travail est une caractéristique exclusivement humaine qui distingue les humains des animaux. Pour lui, la genèse du langage est dans le travail humain et donc le langage se développe parmi nos ancêtres pré-humains ainsi que chez les humains en réponse aux problèmes posés par la vie matérielle. En gardant à l’esprit que le langage découle des exigences sociales et des besoins du monde matériel, selon Thảo le langage se transforme lui-même au fur et à mesure que la société humaine change. Et compte tenu des racines sociales de la pensée et du langage, la conscience évolue continuellement avec le temps. Dans ce cadre, Thảo a voulu déterminer la nature du langage et son rôle dans les sociétés préhistoriques et son évolution à travers les relations sociales. / Several thinkers and scientists throughout the philosophical and scientific tradition took up the relationship between cooperation, language, and social cognition. Among them, Trần Đức Thảoʼs (1917–1993) deserves a special mention. The purpose of the following research is to introduce the reader to Thảoʼs philosophical reflection on human language and its evolution. We shall attempt to map out the main lines of Thảoʼs theory of language origins set out in his Recherches sur l’origine du langage et de la conscience (1973) that combines philosophy, linguistics, psychology, and anthropology. The discovery of Marxism-Leninism led Thảo to suggest a materialistic and dialectic approach to the mind-body problem. In this way, Thảo tried to suggest a materialist and historical turn of Husserl’s philosophy of consciousness which was at the very heart of his own first philosophical interests. Thảo’s account threw into sharp relief the social nature of both language and cognition, so that language evolution is linked inextricably to social relations. Such a view depended upon the assumption that labour is an exclusively human characteristic which sets humans apart from animals. And the genesis of language is in human labour. In this way of thinking, language develops among both our pre-human ancestors and present humans in response to problems posed by the material life. Bearing in mind that language arises from the social demands and needs of the material world, language is transformed itself as human society changes. And given the social roots of thought and language, consciousness evolves continuously over time. Within this framework, Thảo wanted to determine the nature of language and its role in pre-historical societies and its making through social relations.

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Borderline-Persönlichkeitsstörung (BPS) ist eine schwere psychiatrische Störung, die durch tiefgreifende Probleme in Emotionsregulation und zwischenmenschlichen Beziehungen gekennzeichnet ist. Die gestörten Beziehungsmuster werden als ein Kernmerkmal von BPS betrachtet, obwohl die empirische Evidenz dafür weitestgehend fehlt. Bisherige Ergebnisse sind auf behavioraler und neuronaler Ebene bei BPS durch das häufig komorbide Auftreten einer posttraumatischen Belastungsstörung (PTBS) verzerrt. Eine vielversprechende Möglichkeit, die Beziehungsstörung von Patienten mit BPS näher zu untersuchen, bietet das multidimensionale Konzept der Empathie. Daher konzentriert sich die vorliegende Arbeit auf die Identifizierung behavioraler und neuronaler Korrelate kognitiver und emotionaler Empathie bei BPS Patienten und den Einfluss einer komorbiden PTBS auf diese. Die Ergebnisse zeigen, dass Patienten mit BPS Einschränkungen in beiden Facetten von Empathie zeigen, aber komorbide PTBS, intrusive Symptomatik und sexuelle Traumatisierung in der Vergangenheit mit schlechterer kognitiver Empathie einhergehen. Außerdem ist unter kognitiver Empathie die neuronale Aktivität im linken superior temporal Sulcus/Gyrus (STS/STG) bei BPS Patienten reduziert und mit der Ausprägung ihrer intrusiven Symptomatik assoziiert. Während emotionaler Empathie zeigen Patienten mit BPS im rechten insulären Kortex mehr Aktivität, die mit dem Hautleitwiderstand der BPS Patienten assoziiert ist. Die hier dargestellten Ergebnisse unterstützen ein Bild von BPS als eine Störung der emotionalen und kognitiven Empathie. Eine komorbid diagnostizierte PTBS scheint sich dabei zusätzlich verschlechternd auf die Fähigkeit zur kognitiven Empathie auszuwirken. Die veränderte Funktion von STS/STG und Insula könnte einen pathophysiologischen Vermittlungsmechanismus auf neuronaler Ebene für BPS darstellen, dabei scheinen die intrusiver Symptomatik und dem Grad der Erregung der Patienten eine wesentliche Rolle zu spielen. / Borderline personality disorder (BPD) is a severe psychiatric malfunction, which involves deficits in emotion regulation and interpersonal relationships. Especially the interpersonal problems are seen as a core feature in BPD, even if there is only weak empirical evidence. Furthermore, the current results on behavioral and functional alterations of patients with BPD are biased by the high rate of comorbidity with posttraumatic stress disorder (PTSD). The multidimensional concept of empathy seems to be an eligible framework for the interpersonal problems of patients with BPD. Hence, the present work focuses on the identification of behavioral and neural correlates of cognitive (i.e., social cognition) and emotional (i.e., empathic concern) empathy in patients with BPD. Moreover the influence of comorbidities (e.g., PTSD) on the behavioral and neural alterations of patients with BPD was explored. Patients with BPD showed impairments in both facets of empathy, but comorbid PTSD, intrusive symptoms, and history of sexual trauma were only associated with outcomes in cognitive empathy. In this condition the brain responses were significantly reduced in BPD patients compared to controls in the left superior temporal sulcus and gyrus (STS/STG), where this reduction was associated with levels of intrusive symptomatology in the BPD group. During emotional empathy, patients with BPD exhibited greater brain activation than controls in the right middle insular cortex, a response that was associated with skin conductance responses in the patients. Thus, these findings support a conceptualization of BPD as involving deficits in emotional as well as in cognitive empathy. A comorbid PTSD seems to impair the cognitive empathic outcome additionally. Findings at the neural level indicate that altered functioning of the STS/STG and insula represents pathophysiological mediators for BPD, with an important role for intrusive symptomatology and levels of arousal.

Vorangegangene Untersuchungen zeigen, dass emotionale Inputeigenschaften (extrinsische Eigenschaften) das Erlernen neuer Wortbedeutungen bei Kindern befördern. Diese Eigenschaften sind nicht Teil des Referenten, auf den sich ein zu erlernendes Wort bezieht, z.B. der +/-fröhliche Gesichtsausdruck eines Sprechers, der ein unbekanntes Objekt mittels eines neuen Wortes benennt. Die vorliegende Studie konzentriert sich auf zwei bisher unbeachtete Fragen: a) Lassen sich ähnliche Einflüsse finden, wenn die emotionale Inputeigenschaft Teil des Referenten eines zu erlernenden Wortes ist (intrinsische Eigenschaften), z.B. der +/-fröhliche Gesichtsausdruck eines Akteurs in einer durch ein Verb benannten Handlung? b) Beeinflussen diese Eigenschaften die Bedeutung eines neuen Wortes, indem die emotionale Information mitbestimmt, wie das Wort in späteren Kontexten interpretiert wird? Die Ergebnisse zeigen, dass sich im Einklang mit Studien zu extrinsischen Inputeigenschaften die intrinsischen Eigenschaften ebenfalls förderlich auf das Erlernen neuer Wörter bei Kindern auswirken. Darüber hinaus legt die Studie nahe, dass die Wahrnehmung emotionaler Information während des Wortlernens individueller Variabilität unterliegt. Diese beeinflusst wiederum, wie Kinder die Bedeutung des neuen Wortes konstruieren und interpretieren. Verschiedene Faktoren wie Sprachkompetenz, Aufmerksamkeitssteuerung und soziale Kognition werden diskutiert, die individuelle Unterschiede in der Wahrnehmung emotionaler Information beim Wortlernen hervorrufen könnten. / Previous research shows that emotional properties of the input (extrinsic properties) enhance children’s learning of novel words. These properties are not features of the referent a novel word is referring to, e.g. the +/-happy intonation or facial expression of a speaker, who is referring to an object or event by using a novel word. With respect to this finding, the present study focuses on two unnoticed questions: a) Are similar influences found when the emotional properties are features of the referent of the word to be acquired (intrinsic properties), e.g. the +/-happy facial expression of an actor in an event that is labeled by a novel verb? b) Do these properties influence the meaning of a novel word, in that the emotional information constrains how the word is interpreted in later contexts? The results indicate that in line with studies on extrinsic emotional properties children’s learning of novel words is enhanced by intrinsic emotional properties. Furthermore, the study suggests that children’s perception of emotional information while learning a novel word is subject to individual variability, which affects how children construct and interpret the meaning of the novel word. Different factors such as language competence, attentional control and social cognition are discussed for inducing individual differences in emotion perception while word learning.