O presente estudo procurou investigar se procedimentos de discriminações simples, que produzem classes funcionais, poderiam produzir também classes de equivalência. No Experimento 1 utilizou-se o procedimento de discriminações simples sucessivas e reversões. Quatro adultos foram expostos ao treino em que respostas aos estímulos S+ (A1, B1 e C1), mas não aos S- (A2, B2 e C2), eram reforçadas. A seguir, os participantes eram expostos a reversões repetidas das contingências. Testes de relações condicionais emergentes (BA, CB, AC e CA) foram conduzidos por meio do procedimento go/no-go com estímulos compostos, para evitar que os testes envolvessem sequências de respostas possivelmente reforçadas no treino anterior. Os quatro participantes apresentaram responder consistente com a formação de classes funcionais e, três deles, também apresentaram responder indicativo da formação de classes de equivalência. O Experimento 2, investigou se um procedimento de discriminações simples, estabelecidas por meio de respostas diferenciais, que evitava o estabelecimento de sequências de respostas ou discriminações condicionais inadvertidamente, produziria classes funcionais e de equivalência. Outros quatro adultos típicos foram expostos ao treino, em que a Reposta 1 (R1) era reforçada apenas quando emitida na presença de A1, B1 e C1, enquanto a Resposta 2 (R2) era reforçada apenas na presença de A2, B2 e C2. A seguir, uma nova resposta era treinada na presença de um estímulo de cada classe (A1-R3 e A2-R4). Por fim, foram conduzidos Testes de transferência de função e Testes de relações condicionais emergentes (AB, BC, BA, CB, AC e CA) por meio do procedimento go/no-go com estímulos compostos. Os quatro participantes apresentaram responder consistente com a formação de classes funcionais e classes de equivalência. O Experimento 3, teve o objetivo de replicar o procedimento do Experimento 2 com crianças pré-escolares com desenvolvimento típico. Oito das onze crianças formaram classes funcionais e duas delas apresentaram responder consistente com a formação de classes de equivalência, avaliadas por meio do procedimento go/no-go. Outras três crianças também apresentaram responder indicativo da formação de classes de equivalência, apenas posteriormente, quando expostas a testes com o procedimento MTS. O Experimento 4 teve o objetivo de investigar com outras onze crianças se o emprego de outras topografias de respostas, durante o treino de respostas diferenciais, diminuiria a variabilidade dos resultados observados no Experimento 3. Os resultados mostraram que em uma das condições experimentais empregadas, em que as respostas eram mover o mouse ou clicar, nenhuma das cinco crianças apresentou responder consistente com a formação de classes funcionais. Em outra condição experimental, em que as respostas motoras eram gestos, três das seis crianças apresentaram formação de classes funcionais e de equivalência (avaliadas por meio do procedimento go/no-go com estímulos compostos). Em conjunto, os resultados dos quatro experimentos demonstram que procedimentos de discriminações simples podem produzir classes funcionais e também classes de equivalência e apontam que a variabilidade dos desempenhos caracteristicamente encontrada nos experimentos com crianças pode sugerir o efeito de variáveis críticas na aquisição das discriminações e formação de classes funcionais com esta população / This study investigated if simple discrimination procedures, which produce functional classes, could also produce equivalence classes. In Experiment 1, a simple successive discrimination reversal training was used. Four adults were exposed to training in which responses to S+ (A1, B1 and C1), but not to S- (A2, B2 and C2), were reinforced. Next, the participants were exposed to repeated-reversal training. Finally, Emergent conditional relations Tests (BA, CB, AC and CA) were conducted using the go/no-go procedure with compound stimuli to avoid tests involving response sequences adventitiously reinforced during the previous training. The four participants responded consistently with functional class formation and three of them also showed performance indicative of equivalence class formation. Experiment 2 investigated whether a simple discrimination training via differential responses would produce functional and equivalence classes. This training procedure avoided the inadvertently establishment of conditional discriminations or response sequences. Four additional adults were exposed to training procedure in which Response 1 (R1) was reinforced only when emitted in the presence of A1, B1 or C1 and Response 2 (R2) was reinforced only in the presence of A2, B2 or C2. Next, a new response was trained in the presence of one member of each class (A1-R3, A2-R4). Finally, a Transfer of function Test and Emergent conditional relations Tests (AB, BC, BA, CB, AC e CA) were conducted. The four participants responded consistently with functional and equivalence class formation. The purpose of Experiment 3 was replicating Experiment 2 with typically developing preschool children. Eight of the eleven children showed performance indicative of functional class formation and two of them also responded consistently with equivalence class formation, evaluated with the go/no-go procedure. The performance of other three children was also indicative of equivalence class formation, evaluated in tests with the MTS procedure. Experiment 4 investigated, with eleven additional children, if simple discrimination training with different responses topographies would decrease the between subject variability observed in Experiment 3. The results indicated that none of the participants responded consistently with functional class formation in one of the experimental conditions. In the other experimental condition, in which the differential responses were gestures, three of six participants responded consistently with functional and equivalence class formation (evaluated by the go/no-go procedure with compound stimuli). All together, the results of the four experiments demonstrate that simple discrimination procedures can produce functional and also equivalence classes. The variability between subjects specifically found in Experiments 3 and 4 suggests the effects of critical variables on the acquisition of the simple discriminations and functional class formation with children

A implementação de medicamentos genéricos no Brasil e de programas e políticas para garantir o acesso da população a medicamentos com qualidade, segurança e eficácia resultaram em mais de 3.800 medicamentos genéricos de 445 fármacos registrados na Agência Nacional de Vigilância Sanitária (ANVISA) desde 1999. Os medicamentos genéricos comprovaram a sua equivalência terapêutica e, portanto, intercambialidade com seus respectivos medicamentos de referência por meio de estudos de bioequivalência. Em 2014, a ANVISA estendeu a intercambialidade aos medicamentos similares, aumentando o número de medicamentos intercambiáveis para cada medicamento de referência. As normas para prescrição e dispensação permitem apenas a substituição de medicamento de referência por seu medicamento genérico ou similar intercambiável e vice-versa. Entretanto, o que se observa na prática é a substituição entre medicamentos genéricos e similares de um mesmo fármaco, tanto na rede privada onde os descontos chegam até 90% do preço estabelecido para a venda, como na rede pública, em função da disponibilidade dos medicamentos, visto que as compras públicas se baseiam no menor preço ofertado pelos fabricantes. Entretanto, a bioequivalência e a intercambialidade entre os medicamentos genéricos ou similares de um mesmo referência não pode ser garantida pois os mesmos não foram testados entre si. A ausência de bioequivalência entre medicamentos substituídos pode provocar ineficácia terapêutica ou aparecimento de eventos adversos ou até mesmo intoxicação em pacientes. Consequentemente, podem ocorrer desperdício, gastos com tratamento de eventos adversos, abandono do tratamento e adoção de segunda linha de tratamentos. Este trabalho avaliou a bioequivalência entre os medicamentos genéricos e similares de um mesmo medicamento de referência por meio do método de metanálise, empregando dados de estudos de bioequivalência realizados para o registro de medicamentos genéricos e similares na ANVISA. Foram incluídos na análise estudos de aciclovir, amoxicilina, cefalexina, doxazosina, fenitoína, fluoxetina, levofloxacino e quetiapina. Os resultados demonstraram a ausência de bioequivalência entre a maioria dos medicamentos genéricos e similares contendo o mesmo fármaco. os resultados comprovam que medicamentos genéricos e similares de mesmo fármaco não são obrigatoriamente intercambiáveis e a substituição, principalmente para aqueles usados no tratamento de doenças crônicas, podem trazer graves consequências clínicas. Esta preocupação é aumentada para os fármacos com estreita faixa terapêutica e aqueles com alta variabilidade no processo de absorção. A adoção de uma lista de medicamentos não substituíveis, a exemplo de outros países, e o investimento na divulgação de informações sobre intercambialidade de medicamentos, tanto para profissionais de saúde como para a população, podem contribuir para a redução da substituição entre medicamentos não intercambiáveis, a promoção do uso racional dos medicamentos, a redução de gastos com medicamentos e tratamento de eventos adversos e o aumento da adesão do paciente ao tratamento. / The implementation of generic drugs in Brazil, as well as programs and policies to ensure access to medicines with quality, safety and efficacy to the overall population, resulted in more than 3,800 generic drug products of 445 drugs registered in the National Health Surveillance Agency (ANVISA) since 1999. Generic drug products proved their therapeutic equivalence in bioequivalence studies and, therefore, the interchangeability with their respective reference drug product. In 2014, ANVISA expanded the interchangeability to similar drug products, increasing the number of interchangeable drug products for each reference drug product. Regulations for the prescription and dispensation of medicine only allow the substitution of a reference drug product for a generic or an interchangeable similar drug product or vice versa. However, in practice, it appears that there is a substitution between generic and similar drug products of a same reference drug product in private pharmacy chains - where discounts reach up to 90% of the selling price - as well as in public pharmacy, depending on the medicine availability, because public purchases are based on the lower price offered by the manufacturers. Nevertheless, the bioequivalence and interchangeability between generic and similar drug products of the same reference drug product cannot be guaranteed because they haven\'t been evaluated. Lack of bioequivalence between substituted drug products may result in therapeutic ineffectiveness or the occurrence of adverse events and even to patient intoxication. As a consequence, there might be waste, expenses due to adverse events treatment, no adherence to the treatment or the adoption of second-line treatment. This study evaluated the bioequivalence between generic and similar drugs of the same reference drug product through a meta-analysis, using data from bioequivalence studies carried out for the registration of generic and similar drug products at ANVISA. The drugs included in the study were acyclovir, amoxicillin, cephalexin, doxazosin, phenytoin, fluoxetine, levofloxacin and quetiapine. Results showed lack of bioequivalence between most of the generic and similar drugs containing the same drug and prove that generic and similar drug products of the reference drug product are not necessarily interchangeable. Moreover, the substitution of drugs used for chronic illnesses could lead to serious clinical consequences. This concern increases for drugs with narrow therapeutic index and those with high variable absorption process. The adoption of a list of non-interchangeable medicines - like in other countries - and investment in the dissemination of information about interchangeability between drug products to health professionals and to the population may contribute to reduce the substitution of drugs which are not interchangeable, promote a rational use of medicines, the reduction of expenses with drugs and adverse effects treatment and to improve treatment adherence.

O procedimento matching-to-sample (MTS) tem sido amplamente utilizado para o estabelecimento de relações condicionais emergentes. Nesse procedimento, respostas de escolha são emitidas em diferentes localizações. Tal característica pode favorecer o estabelecimento de um controle inadvertido pela localização. No procedimento go/no-go com estímulos compostos, respostas são emitidas em uma única localização. Com o objetivo de avaliar se relações condicionais emergentes poderiam ser produzidas em crianças com autismo a partir do procedimento go/no-go com estímulos compostos, sem o estabelecimento de controle inadvertido pela localização, foram realizados dois estudos. No Estudo 1, quatro crianças autistas, que apresentaram controle pela localização no procedimento MTS, foram submetidas ao treino das relações AB e BC com o procedimento go/no-go com estímulos compostos no qual, respostas emitidas na presença dos estímulos compostos A1B1, A2B2, B1C1 e B2C2 eram seguidas de reforço e respostas na presença de compostos A1B2, A2B1, B1C2 e B2C1 não eram. Em seguida, os participantes realizaram testes para verificar a emergência de relações que não foram diretamente treinadas (BA, CB, AC e CA). Os resultados mostraram que apenas um dos quatro participantes atingiu critério de aprendizado no treino das relações condicionais e exibiu desempenhos consistentes com a emergência de relações de simetria, transitividade e equivalência após a reapresentação de sessões de treino e testes. Todos os participantes apresentaram o padrão de responder em todos os compostos apresentados. Como decorrência do Estudo 1, foi realizado um segundo estudo que pretendeu verificar se relações condicionais emergentes podem ser estabelecidas em indivíduos com diagnóstico de autismo a partir de um treino com o procedimento go/no-go com estímulos compostos em que a duração dos estímulos compostos aos quais o participante não deveria responder foi gradualmente aumentada com o objetivo de evitar respostas diante deles. Para tanto, outras três crianças diagnosticadas com autismo foram submetidas às mesmas fases experimentais do Estudo 1 dentre as quais algumas diferiam pela manipulação na duração dos compostos. Os resultados mostraram que apenas um dos participantes atingiu critério para realização dos testes de Simetria, mas não exibiu desempenho consistente com a emergência de tais relações. Os outros dois participantes não atingiram critério de aprendizagem na fase de Pré-treino ou de Treino, devido ao estabelecimento do padrão de responder em todos os compostos. Os resultados indicam ainda que o procedimento de aumento gradual na duração dos estímulos favoreceu o aprendizado das relações condicionais para um dos participantes, mas pode gerar o estabelecimento do controle inadvertido pela duração dos estímulos. Os participantes que realizaram o treino com o procedimento MTS não atingiram critério de aprendizagem e exibiram desempenhos indicativos do estabelecimento de controle inadvertido pela localização. Concluiu-se que o procedimento go/no-go com estímulos compostos, embora tenha permitido o estabelecimento de desempenhos emergentes para um dos participantes, pode gerar um padrão de responder em todos os compostos mesmo com o procedimento de aumento gradual na duração dos compostos diante dos quais o participante não deve responder. / Matching-to-sample procedure is widely used for establishing emergent conditional relations. However, adventitious control by location, rather than the conditional control, can be established with this procedure in individuals with autism. With the go/no-go procedure with compound stimuli, participants responses are emitted in a single location. Aiming to assess whether emergent conditional relations could be established in autistic children with a go/no-go procedure with compound stimuli, without the establishment adventitious control by location, two studies were conducted. Study 1 sought to verify if the go/no-go procedure with compound stimuli would establish emergent conditional relations in children diagnosed with autism who had control by the location in training with Matching-to-sample procedure. Four autistic children, who showed adventitious control by location in a matching-to-sample task, were submitted to AB and BC training with the go/no-go procedure with compound stimuli. Responses emitted in the presence of A1B1, A2B2, B1C1 and B2C2 compounds were followed by reinforcers and responses emitted in the presence of A1B2, A2B1, B1C2 and B2C1 were not. After that, participants were submitted to tests to verify emergence of conditional relations (BA, CB, AC and CA) that were not directly trained. The results showed that only one of the four participants met the learning criterion in training and exhibited emergent performances in tests only after retraining the baseline relations. In most of the training sessions, all participants responded to all compounds stimuli. These results show that refrain from responding is difficult to be established with the go/no-go procedure in children with autism. Study 2 was conducted to verify if refrain from responding would be established in children with autism if the duration of compounds that should not control responding in training was gradually increased. Other three children diagnosed with autism were submitted to the same procedure as conducted in Study 1, except that during pre-training and training duration of some compounds were gradually increased in some sessions. Results showed that only one participant met the learning criteria in training, but did not showed emergent performances in tests. The other two participants responded to all compounds in most of the sessions. The results indicate that the gradual increase of stimuli duration did not established refrain from responding for some participants and produced adventitious control by stimuli duration for most of them. Although one participant showed emergent performances with the go/no-go procedure with compound stimuli, this procedure can produce responses to all compounds stimuli even when some compounds duration is gradually increased.

Os resultados de Campos et al. (2011) indicaram a emergência de simetria, mas não de transitividade e equivalência em pombos com o procedimento go/no-go com estímulos compostos. O presente experimento investigou a formação de classes em testes de transferência de função após treino com o procedimento go/no-go com estímulos compostos. Quatro pombos foram treinados a responder aos estímulos compostos A1B1, A2B2, B1C1 e B2C2 e a não responder aos compostos A1B2, A2B1, B1C2 e B2C1. Posteriormente, os sujeitos foram treinados a responder em DRL 3 s a A1 e FR20 a A2. Testes de transferência de função apresentaram os estímulos de treino A1 e A2 e os estímulos de teste B1, C1, B2 e C2 para verificar se os sujeitos apresentariam taxa de respostas mais baixa a A1, B1 e C1 e mais alta a A2, B2 e C2. Os sujeitos apresentaram taxas de respostas mais baixas tanto para alguns estímulos do Conjunto 1 quanto para alguns estímulos do Conjunto 2. Portanto, os resultados dos testes de transferência de função não indicaram a formação de classes de equivalência após treino com o procedimento go/no-go com estímulos compostos em pombos. Sendo assim, independentemente dos testes empregados (testes das propriedades com o procedimento go/no-go com estímulos compostos ou teste de transferência de função), desempenhos emergentes não são verificados em pombos após treino com o procedimento go/no-go com estímulos compostos / Campos et al.s (2011) results indicated the emergence of symmetry, but not transitivity and equivalence with pigeons in a go/no-go procedure with compound stimuli. The present experiment investigated stimulus class formation in transfer of function tests after training in a go/no-go procedure with compound stimuli. Four pigeons were trained to respond to A1B1, A2B2, B1C1, and B2C2 compound stimuli e not to respond to A1B2, A2B1, B1C2, and B2C1 compounds. Subsequently, subjects were trained to respond in DRL 3 s to A1 and in FR20 to A2. Transfer of function tests presented the A1 and A2 training stimuli and the B1, C1, B2, and C2 test stimuli to verify if subjects would show a lower response rate to A1, B1, C1 and a higher response rate to A2, B2, C2. Subjects showed lower response rates to some Set-1 stimuli as well as to some Set-2 stimuli. Thus, the results of the transfer of function tests indicate that equivalence classes were not established after training with the go/no-go procedure with compound stimuli in pigeons. Therefore, regardless of the test used (tests of the properties with the go/no-go procedure with compound stimuli or transfer of function tests), emergent performances are not verified in pigeons after training with the go/no-go procedure with compound stimuli

No description available.

The proportion of Canadian prisoners with mental illnesses is rising. Prison administrators are legally responsible for funding and providing access to mental health services for prisoners. Models of service delivery are organized differently in prisons across Canada, and limited scholarly research exists on the efficacy of different approaches to delivering prison mental health care services. The purpose of this case study was to explore the organization and delivery of mental health services in a provincial prison (APP) in Canada. The research question considered how to organize the delivery of these services to meet the needs of prisoners with mental illnesses. The right to health, which holds that services should be available, accessible, appropriate, and of good quality (AAAQ), was applied as the conceptual framework. Data were collected from public documents, observations of the medical clinic and a meeting of a multidisciplinary committee, and individual interviews and focus groups. A total of 31 participants from APP, the provincial health care system, and community-based organizations participated in this study. The data were inductively coded and subjected to pattern matching with emerging themes from multiple sources. Findings indicated that the provincial health care system, not prison administrators, should be responsible for the oversight and management of prison mental health services. Collaboration between the systems is needed in program design and delivering these services. Application of the AAAQ framework against mental health services revealed that the services did not satisfy the right to health and need enhancement. These findings suggest that policy makers could use the AAAQ framework to design and deliver mental health services equivalent to services in the community for the benefit of prisoners.

The term equivalence describes the relationship between a translation and the text from which it is translated. Translation is generally viewed as indeterminate insofar as there is no single acceptable translation - but many. Despite this, the rationalist metaphor of translation equivalence prevails. Rationalist approaches view translation as a process in which an original text is analysed to a level of abstraction, then transferred into a second representation from which a translation is generated. At the deepest level of abstraction, representations for analysis and generation are identical and transfer becomes redundant, while at the surface level it is said that surface textual features are transferred directly. Such approaches do not provide a principled explanation of how or why abstraction takes place in translation. They also fail to resolve the dilemma of specifying the depth of transfer appropriate for a given translation task. By focusing on the translator�s role as mediator of communication, equivalence can be understood as the coordination of information about situations and states of mind. A fundamental opposition is posited between the transfer of rule-like or codifiable aspects of equivalence and those non-codifiable aspects in which salient information is coordinated. The Translation Salience model proposes that Transfer and Salience constitute bipolar extremes of a continuum. The model offers a principled account of the translator�s interlingual attunement to multi-placed coordination, proposing that salient information can be accounted for with three primary notions: markedness, implicitness and localness. Chapter Two develops the Translation Salience model. The model is supported with empirical evidence from published translations of Arabic and English texts. Salience is illustrated in Chapter Three through contextualized interpretations associated with various Arabic communication resources (repetition, code switching, agreement, address in relative clauses, and the disambiguation of presentative structures). Measurability of the model is addressed in Chapter Four with reference to emerging computational techniques. Further research is suggested in connection with theme and focus, text type, cohesion and collocation relations.

<p>The concept of equivalence has for many years attracted attention of researchers in variousdisciplines: from mathematics to philosophy to translation theory to terminology. This thesisintends to survey the concept of equivalence in three subject fields all of which focus onlanguages and communication, namely: translation theory, lexicography and terminology. Thepurpose of the paper is twofold: to investigate the theoretical grounds of equivalence in thesethree disciplines and to survey the methods and practices of establishing equivalence inmultilingual terminology work. The results of the theoretical investigation are summed up onthe basis of the terminological concept analysis. Four concepts systems are structured andpresented in the form of concept diagrams (two for translation theory, one for lexicography andone for terminology). The concept systems give an overview of the current understanding ofequivalence in the three subject fields and expose the relations between equivalence and anumber of related concepts. The central theoretical question of the thesis whether equivalencecould be considered the same concept in all three disciplines is answered on the basis of theresults of the terminological concept analysis. The empirical investigation is carried out in theform of case studies in the frame of multilingual terminology work. It focuses on the problemsof establishing equivalence, of determining the degree of equivalence as well as on the methodsand practices of presenting equivalents in various terminological resources.</p>

<p>This study is grounded in an interest in the Swedish Upper Secondary Schools’ role as an educator of democratic citizens, with a specific interest in the moral and cognitive development of Upper Secondary School students. Development in these two areas is treated as results of citizenship education.</p><p>The purpose of the study is to examine moral and cognitive development of students in Upper Secondary School to see if there are any structural differences to be found between the Upper Secondary School programs that are vocationally oriented and the programs that are preparing for further studies on higher levels – since these differences have been both theoretically and empirically implied. The study is based on an enhanced version of Lawrence Kohlberg’s stages of moral development (with teachers’ evaluations of students’ capacity as a reference point of the students’ actual level of moral development) as well as on Kieran Egan’s theory of development through the use of cognitive tools (as seen in five different “shapes of understanding”). There is also a specific interest in how the teachers’ evaluations of the students’ development in the two areas mentioned coincide. The study has been carried out in the shape of an electronic questionnaire sent to Upper Secondary School teachers in Stockholm.</p><p>The results showed that there were great differences between the evaluations made by teachers working in vocationally oriented programs and by teachers working in programs preparing for further studies on higher levels. Generally, teachers working in programs preparing for further studies on higher levels estimated that their students had a capacity greater than average, whileteachers working in vocationally oriented programs estimated that their students had a capacity below average. Teachers working in “theoretical” programs to a larger extent estimated that their students had a use of cognitive tools which was to be expected from their age, while teachers working in vocationally oriented programs to a larger extent estimated that their students had a use of cognitive tools which could be expected from students not yet fully capable of reading and writing. The results also showed that the groups of students who were said to use cognitive toolsexpected from their age at the same time were estimated to have a relatively low level of capacity.</p>

<p>This dissertation has three goals : to establish an inventory of translation strategies applicable to the translation of metaphor, to investigate how the application of these strategies affects the balance in metaphorical quality between source text and target text, and, finally, to determine whether this balance is a useful indicator of the direction of the translation as a whole, towards either <i>adequacy</i> or <i>acceptability</i>.</p><p>To carry out this research the author has established a corpus comprising 250 metaphors from the novel <i>La goutte d’or</i> by Michel Tournier and its Swedish translation, <i>Gulddroppen</i> by C.G. Bjurström. Based on the criteria <i>thematical and contextual connection</i> 158 metaphors from this corpus have been selected for analysis.The strategy used in the translation of each metaphor has been established. The degree of balance in metaphorical quality between the two texts has then been determined and its significance as an indicator of the direction of the translation as a whole has been discussed.</p><p>The underlying theory and methodology of the study are those of Gideon Toury as outlined in his book <i>Descriptive Translation Studies and beyond</i>. The study is thus essentially descriptive in nature.</p><p>The dissertation is divided into two parts. The first part gives a survey of well known research within the fields of metaphor theory and translation theory. Various theories concerning the requested equality between a text and its translation are presented, as well as inventories of translation strategies established by a number of researchers. The second part contains the analysis of the selected metaphors and establishes a set of strategies for this purpose.</p>