【訂正】注10)に“2011年2月末時点で、収録論文数は9万件を突破している。”とありますが、正しくは“2011年5月末時点”となります。訂正の上、お詫び申し上げます。

Magister Legum - LLM

Determination of cell signalling behaviour is crucial for understanding the physiological response to a specific stimulus or drug treatment. Current approaches for large-scale data analysis do not effectively incorporate critical topological information provided by the signalling network. We herein describe a novel model- and data-driven hybrid approach, or signal transduction score flow algorithm, which allows quantitative visualization of cyclic cell signalling pathways that lead to ultimate cell responses such as survival, migration or death. This score flow algorithm translates signalling pathways as a directed graph and maps experimental data, including negative and positive feedbacks, onto gene nodes as scores, which then computationally traverse the signalling pathway until a pre-defined biological target response is attained. Initially, experimental data-driven enrichment scores of the genes were computed in a pathway, then a heuristic approach was applied using the gene score partition as a solution for protein node stoichiometry during dynamic scoring of the pathway of interest. Incorporation of a score partition during the signal flow and cyclic feedback loops in the signalling pathway significantly improves the usefulness of this model, as compared to other approaches. Evaluation of the score flow algorithm using both transcriptome and ChIP-seq data-generated signalling pathways showed good correlation with expected cellular behaviour on both KEGG and manually generated pathways. Implementation of the algorithm as a Cytoscape plug-in allows interactive visualization and analysis of KEGG pathways as well as user-generated and curated Cytoscape pathways. Moreover, the algorithm accurately predicts gene-level and global impacts of single or multiple in silico gene knockouts. / Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.

L'alternances de climat est un problème important de la préservation de l'environnement. Ces transformations ont de graves conséquences internationales. Sous de nombreuses preuves scientifiques sur la possible variation du climat global dans les années 80 les problèmes concernant les changements de climat ont commencé pénétrer dans des plans politiques de nombreuses associations. La convention des changements de climat global a été signé par les Nations Unies dans la conférence de Rio de Janeiro en 1992. Son objet principal est de stabiliser la concentration de gaz, qui provoque l'effet de cerre dans l'atmosphère à tel point que l'influence humaine pour l'écosystème entière soit limitée. Pour que la réalisation de cette effet soit plus facile, chaque pays doit attribuer l'information régulièrement (les Raports nationaux) sur sa stratégie et ses instruments et aussi l'annuel inventaire de gaz suscitant l'effet de cerre. Dans les quatrièmes assises à Berlin les pays de cette convention (entre eux les membres de la Communauté économique européenne) ont décidé de négocier d'un protocole les moyens de la réduction d'émission pratiquants à été ratifié en 1997. Ce protocole détermine les charges concrètes de réduction de la pollution pour tout les pays qui l'ont ratifié. En plus, 3 mécanismes ont été prévus d'aprés lesquels les pays peuvent accomplir leurs charges ensemble, c'est à dire, réduir les gaz d'échappement qui causent l'effet de cerre: 1. Le mécanisme d'accomplissement des... [to full text]

Com a entrada em vigor do Protocolo de Quioto, intensificam-se as expectativas pela regulamentação de um mercado de créditos de carbono. No caso de esses créditos terem sua origem em projetos de reflorestamento ou de florestamento, conforme previsto pelos chamados Mecanismos de Desenvolvimento Limpo (MDL), vem a ser fundamental o estabelecimento de uma metodologia para quantificação de estoques de carbono armazenados sob a forma de biomassa vegetal. Este trabalho propõe, como um método informatizado para cálculo de estoque de carbono em florestas, um conjunto de funcionalidades e um modelo de dados cadastrais totalmente integrados com um Sistema de Informações Geográficas de arquitetura aberta. A partir de mapas e imagens geo-referenciadas e com base em dados obtidos de pequenos transectos, o sistema calcula a quantidade total de carbono estocada em toda a floresta. Além de permitir apresentar esses resultados para diferentes agentes armazenadores de carbono, como, por exemplo, segmentos de floresta ou cada espécie vegetal, o sistema mantém registro histórico de dados dendrométricos, o que virá permitir a geração de gráficos de curvas de crescimento e, por conseguinte, estimativas futuras. / Increasing expectation for the carbon credit market regulamentation take place as a result of the Kyotos Protocol enforcement. In case of credits that come from reforestation or forestation projects, as foresseen under the Clean Development Mechanism (CDM), it is fundamental to establish a methodology for quantification of carbon stocks stored under the vegetal biomass form. This work proposes, as an informatizated method of forests carbon stocks calculation, a set of functionalities and a cadastre data model totally integrated with an open architeture of Geographyc Information System. Based on maps and images georeferenced on data basis provided by small transectos, the system calculates the total amount of carbon storages all over the forest. Besides allowing to present the results to different storing carbon agents, for instance, forests segments or each vegetal species, the system keeps historical register of dendrometrics data, which will make possible the generation of graphs, curves of growth and, therefore, future evaluation.

Com a entrada em vigor do Protocolo de Quioto, intensificam-se as expectativas pela regulamentação de um mercado de créditos de carbono. No caso de esses créditos terem sua origem em projetos de reflorestamento ou de florestamento, conforme previsto pelos chamados Mecanismos de Desenvolvimento Limpo (MDL), vem a ser fundamental o estabelecimento de uma metodologia para quantificação de estoques de carbono armazenados sob a forma de biomassa vegetal. Este trabalho propõe, como um método informatizado para cálculo de estoque de carbono em florestas, um conjunto de funcionalidades e um modelo de dados cadastrais totalmente integrados com um Sistema de Informações Geográficas de arquitetura aberta. A partir de mapas e imagens geo-referenciadas e com base em dados obtidos de pequenos transectos, o sistema calcula a quantidade total de carbono estocada em toda a floresta. Além de permitir apresentar esses resultados para diferentes agentes armazenadores de carbono, como, por exemplo, segmentos de floresta ou cada espécie vegetal, o sistema mantém registro histórico de dados dendrométricos, o que virá permitir a geração de gráficos de curvas de crescimento e, por conseguinte, estimativas futuras. / Increasing expectation for the carbon credit market regulamentation take place as a result of the Kyotos Protocol enforcement. In case of credits that come from reforestation or forestation projects, as foresseen under the Clean Development Mechanism (CDM), it is fundamental to establish a methodology for quantification of carbon stocks stored under the vegetal biomass form. This work proposes, as an informatizated method of forests carbon stocks calculation, a set of functionalities and a cadastre data model totally integrated with an open architeture of Geographyc Information System. Based on maps and images georeferenced on data basis provided by small transectos, the system calculates the total amount of carbon storages all over the forest. Besides allowing to present the results to different storing carbon agents, for instance, forests segments or each vegetal species, the system keeps historical register of dendrometrics data, which will make possible the generation of graphs, curves of growth and, therefore, future evaluation.

The aim of the thesis is to analyze the design of the present climate and energy policies. The main focus is on how the policy instruments affect the Swedish stakeholders who are included in the European Union’s Emission Trading Scheme (EU-ETS). In-depth interviews have been carried out with representatives from the basic industry, energy utilities as well as industrial and green organizations. The purpose is to illustrate have how these stakeholders view the current policy framework and what amendments that they view as necessary. Suggestions to the Government are given regarding the design of national policies and policy instruments to provide for an improved policy framework. The information and synthesis have furthermore been collected through extensive literature studies as well as participating at conferences and seminars. The thesis is written as a monograph in order to address a larger group of readers interested in the transition of energy systems towards sustainability as well as policy makers and Swedish stakeholders. The common understanding that the global energy systems have to undergo a transition to renewables and higher energy efficiency due to the earth’s finite sources of fossil fuels and uranium presents large challenges for policy makers and business sectors as well as the society in general. Global greenhouse gas (GHG) emissions have to be drastically reduced and the work to achieve this has started through international negotiations such as the Kyoto Protocol. As the present commitment levels are low, an important issue in a short-term perspective is to develop a more comprehensive and efficient system with a much wider participation and more stringent emission targets. In order to achieve current national policy goals and international GHG emission commitments the Swedish Government utilizes a number of policy instruments that are either nationally self-assumed or called for by international agreements or the European Union. The Swedish stakeholders that are included in the EU-ETS face a broad policy framework that has a large impact on their daily operations and future investment strategies. It is imperative for the policymakers, i.e. the Government, to act in accordance with the long-term perspective that the climate change issue and the transition of the energy system require. It is likewise important that any actions are in accordance with the operational and investment climate that the business sector faces. It is argued that these aspects are not fully considered as the success of the next national budget or term of public office seems to overshadow these issues. A long-term perspective is required to provide the business sector with stable and reliable incentives. This is needed to provide the economic conditions under which the businesses can realize investments that will result in emission reductions. Short-term policies reinforce the view of environmental investments as a form of risk investments. This negatively affects the possibility of the policy instruments to effectively achieve established policy goals. Paying attention to these requirements is however not a simple task for policy makers as it will require agreements between the political parties. This demonstrates the main political difficulty with climate change – the requirement of a long-term and full commitment by all state authorities. It should be noted that the thesis does not attempt to describe the Swedish policy makers as neglecting the urgency of acting to mitigate climate change. The national agenda is far to advanced from an international perspective for such statements. The thesis however pinpoints some important issues highlighted by stakeholders, within the business sector and other organizations, who are concerned with the present climate and energy policy framework. Some of the findings are as follows: • Reducing GHG emissions in order to combat climate change must include a long-term perspective • The design of policy instruments should consequently be long-term to increase the support for investments in GHG emission reducing technologies • The design of policies that promote low GHG production alternatives within the energy utilities should be improved • The large potential for reduced GHG emission available through fuel switching and energy efficiency improvements in the Swedish basic industry should be promoted by amended policies • Reformulate or abandon the national GHG emissions target goal with the current formulation • Strive for an emission rights allocation system that is as transparent, fair and predictable as possible • The policy framework should aim for a high level of stability through interaction with the affected stakeholders • These factors are inherently important for the overall efficiency of the policy framework

L'objectif de notre thèse vise à évaluer les résultats engrangés par les marchés du carbone. Afin de pouvoir explorer différents aspects des marchés du carbone à un niveau mondial et en raison de la diversité des instruments qui se cachent derrière ce vocable, nous avons choisi de réaliser une thèse par article. Sur base de nos analyses empiriques nous avons pu vérifier dans quelle mesure les avantages et les limites théoriques des marchés du carbone se sont réalisés en pratique. <p><p>Une hypothèse forte des marchés du carbone dotés d’un système de plafonnement est qu’ils permettraient de garantir le respect des objectifs climatiques. Cette hypothèse ne s’est pas révélée exacte. En générant plus d’un milliard de crédits, dont un nombre important de crédits issus de projets, et en ne parvenant pas à empêcher des défections, le système mis en place par le Protocole de Kyoto n’est pas parvenu à garantir le plafonnement des émissions dans les pays développés. Il en va de même pour les systèmes liés à Kyoto comme le système communautaire d'échange de quotas d'émissions (SCEQE).<p><p>Dans la plupart des configurations des règles ad hoc et peu transparentes ont nui à l’objectif environnemental. La comptabilité commune de différents gaz à effet de serre, malgré des incertitudes importantes sur les pouvoirs de réchauffement globaux a également été néfaste à l'intégrité du système. <p><p>Le lien à des mécanismes de projets trouvant leur légitimité dans une preuve de l’additionnalité souvent floue demeure problématique. Notre analyse a ainsi mis en avant la problématique de l'enregistrement de projets hydrauliques dont la décision de construction est antérieure aux marchés du carbone.<p><p>En théorie, le mécanisme d’échange a pour conséquence que les acteurs confrontés à des coûts de réduction faibles soient encouragés à réduire leurs émissions. Dans la pratique, notre analyse montre que peu d’acteurs connaissent leur coût de réduction marginal, empêchant dès lors la concrétisation de cet idéal d’une réduction au moindre coût. Nous avons aussi mis en avant le fait qu’un prix identique par tonne de CO2 réduite n’est pas adapté au soutien de technologies nouvelles, souvent plus onéreuses au début de leur cycle de développement. <p><p>Finalement, un des principaux mérites des marchés du carbone a peut-être été leur acceptabilité auprès des décideurs politiques et économiques. Il est manifeste que les marchés permettent d'internaliser le carbone à un niveau international sans passer par une difficile harmonisation des politiques fiscales. C'est clairement une des raisons de leur adoption rapide et dans de nombreux pays.<p><p>Les marchés du carbone ont aussi joué un rôle important en matière de sensibilisation aux changements climatiques. Ils ont permis de faire progresser la comptabilité carbone et la compréhension des technologies sobres en carbone. <p><p>L’effondrement récent du prix du carbone montre que ce nouvel instrument qui, en théorie, est efficace pour atteindre un objectif de réduction prédéfini, ne permet pas, dans la pratique, par manque d’ambition ou en raison d’erreurs dans la conception, de financer la transition vers une nouvelle économie sobre en carbone. Il apparaît dès lors nécessaire de réformer cet instrument mais aussi de développer progressivement des alternatives afin de ne pas uniquement faire reposer la réussite de l’atteinte des objectifs climatiques sur les seuls marchés du carbone et ainsi augmenter la résilience des politiques climatiques aux aléas de marchés financiers, par ailleurs eux-mêmes soumis à de nombreux tourments depuis 2008.<p> / Doctorat en Sciences / info:eu-repo/semantics/nonPublished

In accordance with its title, this Thesis Aims to Analyse Legal Aspects of Climate protection. Therefore its structure comprises of Five major sections dedicated to offer substantial amounts of information on the topic of Climate Change and its Protection. The first section describes the Issue of Climate Change, the History of its Protection as well as necessary measures and certain difficulties to achieve a consensus usually occurring during international negotiations. The second, third, and forth sections address Legal Climate Protection at International, European Union, and National Levels. Finally, the closing fifth section not only summarizes all that has been stated in previous sections but also evaluates Efficiency of actions taken at the three levels mentioned. Furthermore, the last section suggests where the major efforts should be focused on in the forthcoming years. All in all, the main objective of all the sections introduced is to Highlight the Urgent Need for Effective and Coordinated Action taken by the Whole International Community based on Conscious and Mindful Doings of each and every Individual. This requirement is the very crucial precondition in order to keep the global rising temperature below 2 degrees celsius by the end of the 21st Century so that potential negative and...

The purpose of this thesis is to analyse the relationship between the EU and the USA with an emphasis on the period after the year 2000. The analysis was only possible with knowledge of preceding milestones that have formed the partnership, the thesis- therefore- begins with the period after the Second World War, to which the European Union can trace its roots. The thesis follows the changes in the relationship during the decades of the Cold War (long-term trends) and in the first decade after its end (short-term trends), and then, due to the broadness of the issue, concrete themes from the period after the year 2000. The thesis also examines the relationship in terms of partnership and conflict, and examines the reasons and events behind the motivation on both sides. The first chapter deals with the Europe-USA relationship development since 1945 and is divided into five parts according to post-war decades. The second chapter deals with the Europe (EU)-USA relationship development after the Cold War up to the beginning of the new millennium. The third chapter represents the centerpiece of the thesis- key issues in the transformation of the relationship. The chapter is divided into four subchapters: divergent and shared opinions on the fight against terrorism (Afghanistan, Iraq), divergent and shared opinions in relation to international organisations and treaties (the Kyoto Protocol, the International Criminal Court), divergent and shared opinions on solving the financial crisis. The fourth subchapter examines the transformation and continuity of the relationship after the accession of the Obama administration.