Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Veronika Křečková Supervisor: PharmDr. Lukáš Červený, Ph.D. Title of diploma thesis: Role of drug transporters in placental transfer of entecavir Entecavir (ETV), an analogue of guanosine, is a highly efficient anti-hepatitis B antiviral drug. It is the first-line therapy for both adults and children. Its use in pregnancy is limited due to a number of factors, including lack of data on placental pharmacokinetics. The placental transition of drugs is frequently controlled by drug transporters. ATP-binding (ABC) transporters, P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) or multidrug resistance-associated protein 2 (MRP2) localized in the apical membrane of syncytiotrophoblast and pumping their substrates in the feto-maternal direction belong to most significant determinants of placental pharmacokinetics. Moreover placental transport of nucleoside-derived drugs can be affected by the activity of nucleoside transporters (NTs); equilibrative nucleoside transporters (ENTs) mediate facilitated diffussion, while the concentrative nucleoside transporters (CNTs) control active influx of their substrates. The aim of the diploma thesis was to describe the role of P-gp, BCRP, MRP2 and NTs (ENTs and...

Made available in DSpace on 2016-04-26T20:30:02Z (GMT). No. of bitstreams: 1 Michelle Marie Caldas Cruz.pdf: 1245921 bytes, checksum: c1b4066327d739e04e73222c687fa4fd (MD5) Previous issue date: 2009-12-15 / Conselho Nacional de Desenvolvimento Científico e Tecnológico / The present work has the aim to study tributary sanctions in the light of the Federal Constitution, analyzing the limits of the punitive power of the State. Therefore, a doctrinal review was made about the juridical norms theories and the concept of sanction. Sanction, in its basic meaning, is considered a penalty. We defend the existence of a unique Punishment Law, based on constitutional principles and in the least intervention of criminal law. We work in the distinction between illicit tributary and tributary crime, between tributary fee and fee due to fiscal crime, pondering about the accumulation of penalties in the criminal and tributary law, showing the differences between insolvency and fiscal evasion. We also emphasize the question of the lack of a legal device that regulates indexation and its application through the Selic index / O presente trabalho se propõe a estudar as sanções tributárias sobre a ótica da Constituição Federal analisando os limites do poder punitivo estatal. Para tanto promovemos um exame doutrinário acerca das teorias da norma jurídica e do conceito de sanção. Consideramos a sanção, em sua acepção estrita, como penalidade. Defendemos a existência de um Direito Sancionador único pautado nos princípios constitucionais e na intervenção mínima do direito penal. Trabalhamos na distinção entre ilícito tributário e delito tributário, entre a multa tributária e a multa decorrente de delito fiscal, ponderando sobre a cumulação de penalidade nas esferas tributária e penal, diferenciando a inadimplência da sonegação fiscal. Enfatizamos ainda a questão da ausência de dispositivo legal que regule a correção monetária e a aplicação desta, através do índice Selic

Made available in DSpace on 2016-04-26T20:48:38Z (GMT). No. of bitstreams: 1 Ernesto Augusto Moura.pdf: 1198193 bytes, checksum: b21520087a411711e38a09c3c376a54f (MD5) Previous issue date: 2013-05-16 / This work has as main objective to analyze the trajectory of intellectual economist Maria da Conceição Tavares, passing its main tests since 1963, when he produced his first essay Heyday and decline of the process of import substitution , through analysis of the processes of capital accumulation and industrialization in Brazil, who scored two major works of the author, as the first thesis professor at UFRJ under the title of capital accumulation and industrialization in Brazil (1974) and the second thesis professor also defended at UFRJ, titled Cycle and crisis: the recent movement of the Brazilian economy (1978). From the 1980s, Tavares continues his reflections now through the prism of a contextual view of international political economy, where advances various trials that have examined the main causes and consequences of financial globalization and weaves a series of critiques of neoliberal policies, especially applied the brazilian economy after the 1990s / Esta dissertação tem como principal objetivo, analisar a trajetória intelectual da economista Maria da Conceição Tavares, perpassando os seus principais ensaios desde 1963, quando produziu o seu primeiro ensaio Auge e declínio do processo de substituição de importações , passando pela análise dos processos de acumulação de capital e industrialização no Brasil, que marcou duas principais obras da autora, a primeira como tese de professora livre-docente da UFRJ sob o título Acumulação de capital e industrialização no Brasil (1974) e a segunda tese de professora titular também defendida na UFRJ, intitulada Ciclo e crise: o movimento recente da economia brasileira (1978). A partir dos anos 1980, Tavares segue suas reflexões agora sob o prisma de uma visão contextual da economia política internacional, onde avança diversos ensaios que procuraram analisar as principais causas e consequências da globalização financeira e tece uma série de críticas às políticas neoliberais, principalmente aplicadas na economia brasileira pós anos 1990

Made available in DSpace on 2017-07-21T14:42:28Z (GMT). No. of bitstreams: 1 Reshad Tawfeiq.pdf: 4057394 bytes, checksum: 401fda5a48a429350eb208c549a4d912 (MD5) Previous issue date: 2015-03-04 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / The following research subscribes itself to the political debate which has as its The following research subscribes itself to the political debate which has as its themes the environment, the relation between the society and nature, the global socio-environmental challenges, and the overcoming of a historical contradiction between the capitalist economy and the lives of humans and other beings. The historical of the industrial and productive processes, which culminated with the neoliberal globalization (around forty years ago), lead the planet to an unprecedented level of devastation, a period during which, contradictorily, there was more talk about nature and the environmental challenge. As such, due to the tragic effects of the historical and social processes of the relation between the capitalist society and the environment – seen as a political, social, economic and cultural totality -, the following research has, as a general objective, to apprehend the mediations between the great and catastrophic environmental tendencies and the policy regarding solid waste in the city of Ponta Grossa/PR, given the current crisis regarding such waste in the city. The goal is to identify and comprehend the way in which this local policy does or does not incorporate the discourse for global rationality. The theoreticalmethodological nucleus of this research was built from the propositions of the worldsystems theory, which were developed through contributions of its main adepts, such as the American sociologist Immanuel Wallerstein; its proposer, Italian political economist Giovanni Arrighi; and the Brazilian thinkers Theotonio dos Santos and Carlos Walter Porto-Gonçalves, who, without abandoning the critical theory and the dialectic method of Marx and his classic categories such as mediation, contradiction, totality and history, promote the reconstruction of some of these categories and take up other new ones to form the central nucleus of their theoretical approach. For the treatment and analysis of the researched data, the qualitative method was utilized. As an instrument of research, the semi-structured interview was utilized, directed at the managers responsible for the policy regarding solid waste in the city of Ponta Grossa/PR. This research, however, inserts itself into a wider proposal within the environmental debate, discussing the rationalities that underlie the relations of the human being with nature, and understanding the environmental challenge not just as an economical and technological one, but, above all, as an ethical, social, and political challenge. / A presente pesquisa se inscreve no debate político que tem por tema o meio ambiente, a relação sociedade-natureza, os desafios socioambientais globais e a superação de uma contradição histórica entre economia capitalista e equilíbrio da vida humana e dos demais seres bióticos. O histórico dos processos industriais e produtivos, que culminou na globalização neoliberal (há cerca de 40 anos), conduziu o planeta a uma devastação sem precedentes em toda a história da humanidade, período em que, contraditoriamente, mais se falou da natureza e em que o próprio desafio ambiental se colocou como tal. Desta forma, em razão dos trágicos efeitos dos processos históricos e sociais da relação entre sociedade capitalista e natureza - vista como totalidade política, social, econômica e cultural - o presente trabalho tem por objetivo geral apreender na crise contemporânea dos resíduos sólidos no município de Ponta Grossa/PR as mediações existentes entre as grandes e catastróficas tendências ambientais globalizadas e a política municipal de resíduos sólidos, procurando identificar e compreender a forma com a qual esta política local incorpora ou não o discurso da racionalidade global. O núcleo teórico-metodológico desta pesquisa foi construído a partir das proposições da teoria sistema-mundo, desenvolvidas através das contribuições de seus principais adeptos, como o sociólogo estadunidense Immanuel Wallerstein, seu propositor, o economista político italiano Giovanni Arrighi, e os pensadores brasileiros Theotonio dos Santos e Carlos Walter Porto-Gonçalves, que, sem abandonarem a teoria crítica e o método dialético de Marx e suas clássicas categorias como mediação, contradição, totalidade e história, promovem a reconstrução de algumas destas categorias e se apropriam de outras novas para formar o núcleo central de sua abordagem teórica. Para o tratamento e análise dos dados pesquisados utilizou-se o método qualitativo. Como instrumento de pesquisa, utilizou-se a entrevista semi-estruturada dirigida aos gestores responsáveis pela política de resíduos sólidos no município de Ponta Grossa/PR. Este trabalho, portanto, insere-se numa proposta mais ampla dentro do debate ambiental, discutindo as racionalidades subjacentes às relações do homem com a natureza e compreendendo o desafio ambiental não apenas como um desafio econômico e tecnológico, mas, sobretudo, como um desafio ético, social e político.

Made available in DSpace on 2015-03-04T21:16:00Z (GMT). No. of bitstreams: 0 Previous issue date: 26 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / Esta tese é resultado da pesquisa de doutorado, realizada no Programa de Pós Graduação em Educação da Universidade do Vale do Rio dos Sinos (UNISINOS). A investigação situa-se no campo de estudos Trabalho-Educação, tendo como foco a educação profissional técnica de nível médio. A pesquisa teve como objetivo geral discutir a educação profissional dos técnicos, através da revisão do conceito de qualificação profissional, considerando: o processo de formação profissional, o processo de aprendizagem que ocorre no trabalho e a convergência com as exigências decorrentes do modelo de acumulação flexível. Visou-se, portanto, conhecer o processo de constituição das competências dos profissionais técnicos, que contribuem para o ingresso e manutenção, no mercado de trabalho. Trata-se de um estudo de caso, de natureza qualitativa, cujos sujeitos são egressos do curso técnico em plásticos, da UNED Sapucaia do Sul (CEFET/RS), no período de 1999 a 2004, assim como professores e gestores da Escola. As informações foram cole / This thesis is the result of the research of Doctorate on the program of Education Postgraduate at "Universidade do Vale do Rio dos Sinos - UNISINOS". The research carries out studies about Work-Education and focuses on the High-technical school and professional education. The general purpose of the research was to discuss the professional education of the technical course, through a review of the concept of professional qualification, considering: the process of professional formation, the learning process which happens during work and the convergence with decurrent requirements from the model of flexible accumulation. Therefore, it was focused the importance of knowing the process of the constitution of the technical professionals competences, which contribute for the ingression and maintenance at the work market. The study is about a Case with qualitative nature on which the subjects are the graduated students from the technical course, at UNED in Sapucaia do Sul (CEFET-RS) during the period of 1999-2004

Estratégia de corrida é forma pela qual os corredores distribuem a velocidade durante uma competição. Objetivando otimizar a utilização dos recursos energéticos, bem como melhorar o desempenho geral na prova, durante uma corrida de 5 km os atletas comumente adotam uma estratégia caracterizada por um início em alta velocidade, seguido por um trecho intermediário em velocidade inferior, e finalmente os atletas aumentam a velocidade quando se aproximam dos 400 m finais da prova. Sabe-se que o treinamento intervalado de alta intensidade (TIAI) realizado ao longo de 3 a 6 semanas é capaz de promover melhoras significativas nas variáveis fisiológicas determinantes do desempenho aeróbio, tais como VO2max, EC, VP, e OBLA. Uma vez que os atletas monitoram a PSE baseado em sinais internos (fisiológicos) e externos (ambiente), e desta forma alteram a velocidade para evitarem o término prematuro do exercício, acredita-se que melhoras em tais variáveis fisiológicas possam permitir que os corredores modifiquem a estratégia de corrida. Portanto, o principal objetivo do presente estudo foi analisar a influência de quatro semanas de TIAI sobre a PSE e também sobre a estratégia de corrida adotada por corredores durante um teste contra-relógio de 5 km (T5). Vinte sujeitos, homens, corredores recreacionais de longa distância foram distribuídos de forma contrabalançada em grupo controle (CON, n = 10; 33,5 ± 6,2 anos) e grupo treinamento intervalado (TINT, n = 10; 32,9 ± 8,6 anos). TINT realizou uma sessão de TIAI duas vezes por semana, enquanto que CON manteve seu programa regular de treinamento. Antes e após o período de intervenção, os corredores realizaram: 1) um teste incremental até exaustão para se obter o início do acúmulo de lactato sanguíneo (OBLA), o consumo máximo de oxigênio (VO2max), e a velocidade pico em esteira (VP); 2) um teste submáximo de carga constante para se medir a economia de corrida (EC); 3) e um teste contra-relógio de 5 km (T5) em pista para se estabelecer a estratégia de corrida. O programa de TIAI produziu uma melhora relevante no VO2max (effect size = 0,219), OBLA (effect size = 0,489), EC (effect size = -0,593), e VP (effect size = 0,622). Não foram detectadas alterações significativas na estratégia de corrida, TT5, VT5 e PSET5 durante o T5, comparando ambas as condições (pré e pós-treinamento) ou entre os grupos (TINT e CON; P > 0,05). Esses achados sugerem que melhoras nas variáveis fisiológicas induzidas por um programa de quatro semanas de TIAI não são acompanhadas por alterações similares na PSE e na estratégia de corrida durante um teste contra-relógio de 5 km / Pacing strategy has been defined as the manner by which the runners distribute their speed during a competition. In order to optimize the use of the energetic resources, as well as improve the general race performance, during a 5-km running race, athletes usually adopt a pacing strategy characterized by a fast start (400 m), followed by a period of slower speed during the middle (400 4600 m), and a significant increase in running speed during the last part of the race (400 m). It is well recognized that high-intensity interval training (HIIT) performed along 3 to 6 weeks is able to promote significant improvements in physiological variables determinants of endurance performance, such as VO2max, RE, PTS, and OBLA. Since athletes monitor their RPE based on the internal (physiological) and external (environment) signals, and change their running speed in order to prevent a premature exercise termination, its believed that improvements in such physiological variables could enable athletes to modify the pacing strategy. Thus, the main purpose of this study was to analyze the influence of 4 weeks of high-intensity interval training (HIIT) on the rating of perceived exertion (RPE) and the pacing strategy adopted by runners during a 5-km running time-trial (T5). Twenty male, recreational long-distance runners were randomly assigned into control group (CG, n = 10) or high-intensity interval-training group (HIITG, n = 10). The HIITG performed a high-intensity interval-training session twice per week, while CG maintained its regular training program. Before and after the training period, the runners performed the following tests: 1) an incremental exercise test to exhaustion to measure the onset of blood lactate accumulation (OBLA), maximal oxygen uptake (VO2max), and peak treadmill speed (PTS); 2) a submaximal speed-constant test to measure the running economy (RE); 3) a 5-km running time-trial on an outdoor track to establish pacing strategy. HIIT program produced a relevant improvement on the VO2max (effect size = 0.219), OBLA (effect size = 0.489), RE (effect size = -0.593), and PTS (effect size = 0.622). There were no significant differences on pacing strategy, TT5, ST5 and RPE response during the 5-km running time-trial between both conditions (pre- and post-training) or between groups (HIITG and CG; P > 0.05). These findings suggest that improvements on the physiological variables induced by a 4-week HIIT program are not accompanied by similar modifications on the RPE and running pacing strategy during a 5-km running time-trial

A população de foraminíferos e tecamebas no SELCI evidenciou variação espacial, caracterizando alta dominância de hialinos e porcelanáceos no verão, e aglutinantes no inverno. Essa distribuição da microfauna estava associada a maior influência marinha dos setores externos e a forte influência do regime regional de chuvas nos setores internos. Constatou-se como bioindicadores a espécie Pararotalia cananeiaensis indicando o alcance da cunha salina nas porções internas do sistema, os miliolídeos indicando ambientes com renovação de águas marinhas e fluxos mais energéticos no sistema, o gênero Miliammina spp. e as tecamebas indicando ambientes de baixa salinidade. Através do Ic foi possível detectar o impacto do balanço entre as influências continentais e marinhas no sistema, com a intrusão salina sazonalmente distinta, devido às próprias condições regionais e geomorfológicas do sistema. Na tentativa de encontrar ambientes hipóxicos foi aplicado o IAE, porém este índice não gerou resultados satisfatórios neste sistema estuarino, visto que outros fatores representaram ser variáveis mais importantes do que a concentração de oxigênio dissolvido. O cálculo da BFAR foi testado revelando que a geomorfologia do SELCI foi um fator determinante na distribuição das espécies e que a BFAR foi uma medida qualitativa do fluxo de MO no sistema. Através das análises estatísticas multivariadas foi possível determinar as associações da microfauna, sendo estas condicionadas, nas duas campanhas, principalmente pelos fatores salinidade, substrato e profundidade. / The population of foraminifera and thecamoebians in the CILES (Cananéia-Iguape Lagoon Estuarine System) evidenced spatial variation, characterizing high dominance of hyalines and porcelanaceous during the summer and agglutinated in the winter. This microfauna distribution was associated to stronger marine influence in the outer sections and to strong regional pluviosity in the inner sections. The bioindicator species were Pararotalia cananeiaensis, evidencing the extent of the salt water wedge in the inner portion of the system, the miliolidae, indicating environments with renewal of marine water and more energetic fluxes in the system and the gender Miliammina spp. and thecamoebians indicating areas of low salinity. Trough the Ic it was possible to identify the impact of the balance between marine and fresh waters influence in the system, with saline intrusion seasonally distinct, due to the system\'s own regional and morphological conditions. An attempt to identify hypoxia areas was made using the AEI (Ammonia-Elphidium Index) test, however, this index did not reveal satisfactory results in this estuarine system, since other factors seem to be more representative than the dissolved oxygen concentration. The geomorphology of the CILES was proved to be a determinant factor in the distribution of the species through the BFAR (Benthic Foraminifera Accumulation Rate) calculation, which was also a qualitative measure of the flux of organic matter (TOC) in the system. Statistical analysis proved that the associations of microfauna, was driven, in both campaigns, by salinity, substract and depth.

The Rhodesian and Zimbabwean space-time involved the creation and adoption of hegemonic discourses that influenced ways of behavior, thinking, perceiving reality and particular ways of identity construction based on mystifying nationalisms. In raced and politically charged spaces, such grand narratives depended, for their currency, on stereotypes, essentialisms, domination and dichotomization of ‘nation as narration’. The metanarratives of the two spaces functioned as discursive tools for the legitimation of particular forms of exclusions, elisions and distortions. As discursive and polemical literary tools, these discourses always found sustenance and perpetuation in the existence of a different other. In other words, these constructed narratives sought to use difference as a basis for scapegoating and naturalizing racial, economic, political and resource asymmetries in the Rhodesian and Zimbabwean spaces. Power was wielded not in the service of, but against, the majority who are marginalized. This study explores John Eppel’s writings on the constructions of both Rhodesia and Zimbabwe as ideological spaces for the legitimation of power based on class, race and politics. I argue that Eppel’s selected writings are a literary intervention that proffers a satirically dissident critique of the foundational myths, symbols and narratives of Rhodesian and Zimbabwean space-time. The study argues that Eppel offers literary resistance to unproblematized identity compositions predicated on socially constructed but skewed categories that limit the contours of belonging and citizenship. The Rhodesian space is viewed as a palimpsest upon which is overwritten the Zimbabwean patriotic discourse that also authorize racism, marginalization, power abuse and other forms of exclusion. In examining Eppel’s satiric disruption of both spaces, I use certain strands of the Postcolonial Theory that problematize issues of nation, identity, race, tribe and power. Its usefulness lies in its rejection of fixities, of absolutes and in its general counter-hegemonic thrust. I therefore invoke the theorizations of Frantz Fanon, Homi Bhabha, Maria Lara, Paul Gilroy, Mikhail Bakhtin and Benita Parry. These form the theoretical base with which the study confronts Eppel’s writings on Rhodesia and Zimbabwe. The focal texts used are: Absent: The English Teacher (2009), selected short stories in White Man Crawling (2007) and The Caruso of Colleen Bawn (2004), The Holy Innocents (2002), Hatchings (2006), selected poems from Spoils of War (1989), Songs my Country Taught me: Selected Poems 1965-2005(2005) and D.G.G.Berry’s The Great North Road (1992). I conclude by arguing that Eppel creates a fictional life-world where race, origin, politics, class and culture are figured as polarizing identity markers that should be re-negotiated and even transcended in order to materialize a more inclusive multicultural society. To the extent that both the colonial and post-independence eras cross-fertilize each other in terms of occlusions, creating hegemonic narratives, resort to race, violence, silencing and erasure of certain subjectivities, Eppel advocates the ‘hatching’ of a new national, moral and inclusive ethos that supersedes the claustrophobia of both spaces. / English Studies / D. Litt. et Phil.(English)

Ce travail de thèse propose une méthodologie d’instrumentation reposant sur plusieurs outils hydrologiques, géophysiques et géochimiques afin de quantifier l’apport nival dans les débits du Lignon. Cette instrumentation consiste en un suivi des échanges aux différents compartiments/interfaces hydrologiques que forment l’atmosphère, la neige, le sol et les cours d’eau au cours des saisons. La neige, et surtout l’équivalent en eau liquide qu’elle représente, est fondamentale pour la compréhension du fonctionnement des sources du Lignon, situées à l’aval direct d’une congère de grand volume. Ce volume d’eau est stocké durant la saison froide pour être restitué lors de la fonte printanière. Cette restitution est loin d’être homogène dans le Haut Lignon, en raison de la forte variabilité spatio-temporelle des paramètres qui la pilotent.L’infiltration de l’eau alors produite est une étape clef dans le comportement hydrologique du Lignon au printemps. La structure du sol à proximité des sources explique également la forte dépendance des sources du Lignon par rapport aux précipitations neigeuses. Cette dépendance est particulièrement visible lors de la fonte de la neige, qui modifie à très court terme les débits aux sources. Cette relation neige-pluie-débit met en évidence une alimentation superficielle pluvio-neigeuse prépondérante par rapport aux débits issus d’eau plus profonde, mais variable au cours de l’année.La méthode d’instrumentation employée, adaptée à l’hydrologie locale employée, permet de corroborer les résultats obtenus avec une précision appréciable, tout en ouvrant de nouvelles perspectives d’application à d’autres bassins versants d’altitude. / This work proposes a methodology for an instrumentation based on several hydrological, geophysical and geochemical tools, to quantify the contribution of snowmelting proportions in the Lignon. This instrumentation is a monitoring of the different compartments / hydrological interfaces made up by atmosphere, snow, soil and rivers throughout the seasons.Snow, and especially the snow water equivalent, is fundamental to a better hydrological understanding of the sources of the Lignon, located directly downstream of a large snowdrift. This amount of water is stored during the cold season, to be returned during the spring melting. This return is heterogeneous in the top of the Lignon, due to the high spatial and temporal variability of parameters leading the melting.The infiltration of water therefore produced is a key step in the hydrological behavior of the Lignon during the spring time, which can be potentially more affected by the freezing of the ground, which significantly increases surface runoff.Soil structure near sources also explains the strong dependence of the sources of the Lignon towards snowfalls and rains. This dependence is especially noticeable at the snow melting that changes with very short term the flows at the sources.This snow-rainfall-runoff relationship highlights a predominant rain-snow surface supply, in comparison with the deeper water flows, and variable during the year.This instrumentation method, adapted to the local scale hydrology, allows corroborating the results obtained with a good accuracy, while opening new opportunities for application to other altitude watersheds.

Estratégia de corrida é forma pela qual os corredores distribuem a velocidade durante uma competição. Objetivando otimizar a utilização dos recursos energéticos, bem como melhorar o desempenho geral na prova, durante uma corrida de 5 km os atletas comumente adotam uma estratégia caracterizada por um início em alta velocidade, seguido por um trecho intermediário em velocidade inferior, e finalmente os atletas aumentam a velocidade quando se aproximam dos 400 m finais da prova. Sabe-se que o treinamento intervalado de alta intensidade (TIAI) realizado ao longo de 3 a 6 semanas é capaz de promover melhoras significativas nas variáveis fisiológicas determinantes do desempenho aeróbio, tais como VO2max, EC, VP, e OBLA. Uma vez que os atletas monitoram a PSE baseado em sinais internos (fisiológicos) e externos (ambiente), e desta forma alteram a velocidade para evitarem o término prematuro do exercício, acredita-se que melhoras em tais variáveis fisiológicas possam permitir que os corredores modifiquem a estratégia de corrida. Portanto, o principal objetivo do presente estudo foi analisar a influência de quatro semanas de TIAI sobre a PSE e também sobre a estratégia de corrida adotada por corredores durante um teste contra-relógio de 5 km (T5). Vinte sujeitos, homens, corredores recreacionais de longa distância foram distribuídos de forma contrabalançada em grupo controle (CON, n = 10; 33,5 ± 6,2 anos) e grupo treinamento intervalado (TINT, n = 10; 32,9 ± 8,6 anos). TINT realizou uma sessão de TIAI duas vezes por semana, enquanto que CON manteve seu programa regular de treinamento. Antes e após o período de intervenção, os corredores realizaram: 1) um teste incremental até exaustão para se obter o início do acúmulo de lactato sanguíneo (OBLA), o consumo máximo de oxigênio (VO2max), e a velocidade pico em esteira (VP); 2) um teste submáximo de carga constante para se medir a economia de corrida (EC); 3) e um teste contra-relógio de 5 km (T5) em pista para se estabelecer a estratégia de corrida. O programa de TIAI produziu uma melhora relevante no VO2max (effect size = 0,219), OBLA (effect size = 0,489), EC (effect size = -0,593), e VP (effect size = 0,622). Não foram detectadas alterações significativas na estratégia de corrida, TT5, VT5 e PSET5 durante o T5, comparando ambas as condições (pré e pós-treinamento) ou entre os grupos (TINT e CON; P > 0,05). Esses achados sugerem que melhoras nas variáveis fisiológicas induzidas por um programa de quatro semanas de TIAI não são acompanhadas por alterações similares na PSE e na estratégia de corrida durante um teste contra-relógio de 5 km / Pacing strategy has been defined as the manner by which the runners distribute their speed during a competition. In order to optimize the use of the energetic resources, as well as improve the general race performance, during a 5-km running race, athletes usually adopt a pacing strategy characterized by a fast start (400 m), followed by a period of slower speed during the middle (400 4600 m), and a significant increase in running speed during the last part of the race (400 m). It is well recognized that high-intensity interval training (HIIT) performed along 3 to 6 weeks is able to promote significant improvements in physiological variables determinants of endurance performance, such as VO2max, RE, PTS, and OBLA. Since athletes monitor their RPE based on the internal (physiological) and external (environment) signals, and change their running speed in order to prevent a premature exercise termination, its believed that improvements in such physiological variables could enable athletes to modify the pacing strategy. Thus, the main purpose of this study was to analyze the influence of 4 weeks of high-intensity interval training (HIIT) on the rating of perceived exertion (RPE) and the pacing strategy adopted by runners during a 5-km running time-trial (T5). Twenty male, recreational long-distance runners were randomly assigned into control group (CG, n = 10) or high-intensity interval-training group (HIITG, n = 10). The HIITG performed a high-intensity interval-training session twice per week, while CG maintained its regular training program. Before and after the training period, the runners performed the following tests: 1) an incremental exercise test to exhaustion to measure the onset of blood lactate accumulation (OBLA), maximal oxygen uptake (VO2max), and peak treadmill speed (PTS); 2) a submaximal speed-constant test to measure the running economy (RE); 3) a 5-km running time-trial on an outdoor track to establish pacing strategy. HIIT program produced a relevant improvement on the VO2max (effect size = 0.219), OBLA (effect size = 0.489), RE (effect size = -0.593), and PTS (effect size = 0.622). There were no significant differences on pacing strategy, TT5, ST5 and RPE response during the 5-km running time-trial between both conditions (pre- and post-training) or between groups (HIITG and CG; P > 0.05). These findings suggest that improvements on the physiological variables induced by a 4-week HIIT program are not accompanied by similar modifications on the RPE and running pacing strategy during a 5-km running time-trial