Global ETD Search

31	Biological functions of microRNA-216 and microRNA-217 during the development of pancreatic cancer Azevedo-Pouly, Ana Clara P. 17 October 2013 (has links) No description available. Pharmaceuticals Oncology Molecular Biology microRNA miR-217 miR-216a miR-216b cancer pancreas pancreatic cancer development PDAC REST CDH1 Zeb1 embryonic lethality GEMM mouse models ADM acinar ductal
32	Les armes de destruction massive : essai critique sur une notion à géométrie variable Gata, Aude Marie-Laurence 14 December 2012 (has links) La notion d'« armes de destruction massive » (ADM) est insaisissable : au lieu d'avoir pour but de mieux définir un type d'arme, elle agit à l'inverse, en créant une confusion entre l'arme et les conséquences de son emploi. Cette nature inconsistante se poursuit au niveau juridique. En effet, bien que l'expression fasse très tôt son entrée au sein des Nations unies, aucun traité ni organe officiel n'a, jusqu'alors, réussi à en donner une définition probante. À défaut de définition incontestable, et en l'absence d'un critère vérifiable d'identification de ce qu'est une « arme de destruction massive », cette notion s'est avérée préjudiciable. L'écart entre la réalité de la menace existante en matière d'« armes de destruction massive » et la façon dont elle fut perçue, puis gérée par la communauté internationale, c'est-à-dire à la fois par les États de façon individuelle et par les organisations internationales et les traités de façon collective, a conduit à de multiples dérives. Par conséquent, s'agissant là d'une notion plus politique que juridique, il apparaît nécessaire qu'elle soit précisée ou abandonnée / The term « weapons of mass destruction » (WMD) is ambiguous: instead of aiming to clearly define a certain type of weapon, it does the opposite by creating confusion between the weapon itself and the consequences of its use. This confusion is also reflected at in the legal definition. Indeed, even though the term has been used by the United Nations from an early stage, no treaty or official entity has succeeded in providing a clear definition to this day. The lack of a clear definition, and the absence of defined criteria to determine what constitutes a « weapon of mass destruction », has turned out to be damaging. The dichotomy between the existing threat from « weapons of mass destruction » and the way it is perceived and handled by the international community, including individual states, international organisations, as well as collective treaties, has resulted in several instances of inappropriate use. As a consequence, the term has become a political rather than legal notion. A clearer legal definition is needed, or otherwise the term should be abandoned « armes de destruction massive » (ADM) Armes non-conventionnelles Armes nucléaires Armes biologiques Armes chimiques Désarmement Non-prolifération Sécurité Maîtrise des armements Propagande « weapons of mass destruction » (WMD) Non-conventional weapons Nuclear weapons Biological weapons Chemical weapons Non-proliferation Security Arms control Propaganda
33	The Asperity-deformation Model Improvements and Its Applications to Velocity Inversion Bui, Hoa Q. 16 January 2010 (has links) Quantifying the influence of pressure on the effective elastic rock properties is important for applications in rock physics and reservoir characterization. Here I investigate the relationship between effective pressure and seismic velocities by performing inversion on the laboratory-measured data from a suite of clastic, carbonate and igneous rocks, using different analytic and discrete inversion schemes. I explore the utility of a physical model that models a natural fracture as supported by asperities of varying heights, when an effective pressure deforms the tallest asperities, bringing the shorter ones into contact while increasing the overall fracture stiffness. Thus, the model is known as the ?asperity-deformation? (ADM) or ?bed-of-nails? (BNM) model. Existing analytic solutions include one that assumes the host rock is infinitely more rigid than the fractures, and one that takes the host-rock compliance into account. Inversion results indicate that although both solutions can fit the data to within first-order approximation, some systematic misfits exist as a result of using the rigid-host solution, whereas compliant-host inversion returns smaller and random misfits, yet out-of-range parameter estimates. These problems indicate the effects of nonlinear elastic deformation whose degree varies from rock to rock. Consequently, I extend the model to allow for the pressure dependence of the host rock, thereby physically interpreting the nonlinear behaviors of deformation. Furthermore, I apply a discrete grid-search inversion scheme that generalizes the distribution of asperity heights, thus accurately reproduces velocity profiles, significantly improves the fit and helps to visualize the distribution of asperities. I compare the analytic and numerical asperity-deformation models with the existing physical model of elliptical ?pennyshape? cracks with a pore-aspect-ratio (PAR) spectrum in terms of physical meaning and data-fitting ability. The comparison results provide a link and demonstrate the consistency between the use of the two physical models, making a better understanding of the microstructure as well as the contact mechanism and physical behaviors of rocks under pressure. ADM-based solutions, therefore, have the potential to facilitate modeling and interpretation of applications such as time-lapse seismic investigations of fractured reservoirs. ADM Asperity-Deformation bed-of-nails seismic velocity nonlinear inversion pressure effects nonlinear elastic fracture fractured reservoir rock physics reservoir characterization rigid-host compliant-host nonlinear deformation host-rock pressure dependence asperity in contact visco-elasticity
34	Staff nurse perceptions' of nurse manager caring behaviors: psychometric testing of the Caring Assessment Tool-Administration (CAT-adm©) Wolverton, Cheryl Lynn 04 April 2016 (has links) Indiana University-Purdue University Indianapolis (IUPUI) / Caring relationships established between nurse managers and staff nurses promote positive work environments. However, research about staff nurses' perceptions of nurse manager caring behaviors is limited. A 94-item Caring Assessment Tool-Administration (CAT-adm©) was developed to measure staff nurses' perceptions of nurse managers' caring behaviors; however, it lacked robust psychometric testing. This study was undertaken to establish the CAT-adm© survey as a reliable and valid tool to measure staff nurses' perceptions of nurse managers' caring behaviors. The Quality-Caring Model® (QCM®) served as the theoretical framework. Specific aims were to 1) evaluate construct validity of the CAT-adm© survey by describing factors that account for variance in staff nurses' perceptions of nurse manager caring, 2) estimate internal consistency, and 3) conduct item reduction analysis. Four research questions were: 1) Will the factor structure of observed data fit an 8-factor solution? 2) What is the internal consistency reliability of the CAT- adm©? 3) What items can be reduced while maintaining an acceptable factor structure? and 4) What are staff nurses' perceptions of nurse manager caring behaviors? A cross-sectional descriptive design was used. A sample of 703 staff nurses from Midwestern, Midatlantic and Southern Regions of the U.S. completed the CAT-adm© survey electronically. Analysis included Confirmatory Factor Analysis (CFA), Exploratory Factor Analysis (EFA), univariate analysis, and descriptive statistics. CFA did not support an 8-factor solution. EFA supported a two-factor solution and demonstrated significant shared variance between the two factors. This shared variance supported a one-factor solution that could conceptually be labeled Caring Behaviors. Random selection reduced the scale to 25-items while maintaining a Cronbach's Alpha of .98. Using the new 25-item scale, the composite score mean of staff nurses' perceptions of nurse manager caring behaviors indicated a moderately high level of caring. Suggestions for nursing administration, nurse manager practice, leadership, education and for future research were given. The new 25-item CAT-adm© survey has acceptable reliability and validity. The 25-item CAT-adm© survey provides hospital administrators, nurse managers, and researchers with an instrument to collect valuable information about the caring behaviors used by nurse managers in relationship with staff nurses. Caring Assessment Tool - Adm Caring behaviors Caring relationships Positive work environment Staff nurse - nurse manager relationship Staff nurse perceptions - nurse manager Nursing Nurse administrators Nurses Job satisfaction Hospitals -- Administration Work environment Social surveys Social surveys -- Data processing
35	Uppkomsten och inverkan av automatiserat beslutsfattande inom försörjningsstöd : en litteraturstudie / The Rise and Impact of Automated Decision Making in Social Assistance : A Literature Review Wharton, Amy, de Koning, Sirah Carlos Raoul January 2024 (has links) Bakgrunden till detta examensarbete tar avstamp i automatiseringens utbredning inom välfärdssektorn. En aktiv digitaliseringspolitik bedrivs på nationell nivå där argument som effektivitet och rättssäkerhet motiverar implementeringen av ADM, eller automatiserat beslutsfattande. Dock har denna politik en inverkan på det sociala arbetets handlingsutrymme och hur det bedrivs. Syftet med studien är därmed att undersöka hur automatiserat beslutsfattande påverkar biståndshandläggares handlingsutrymme. Metodansatsen i examensarbetet är en litteraturstudie av kvalitativ karaktär vars empiri utgörs av vetenskapliga artiklar. Dessa artiklar har sedan studeras med hjälp av tematisk analys, där vi utifrån extrakt i datamaterialet ringat in återkommande mönster och generella temana. Resultaten analyseras och diskuteras utifrån nyinstitutionell teori och Lipskys teori om gräsrotsbyråkrati. Våra fynd pekar på att automatiserat beslutsfattande ökar såväl som minskar handlingsutrymmet samt i de flesta fall medfört en organisatorisk uppdelning av försörjningsstödet, där handläggare får antingen mer klienttid eller fler ärenden att övervaka. Vidare visar resultaten att arbetsmarknadsåtgärder i många fall förflyttats från handläggare till jobbcoacher. Utifrån vår teoretiska analys drar vi slutsatsen att automatiserat beslutsfattande utesluter och/eller omdefinierar Lipskys handlingsutrymme. Vi kommer även fram till att det höjer rättssäkerheten samt både kan öka och inskränka möjligheten till relationsskapande. Avslutningsvis kan automatiserat beslutsfattande förstås som en nödvändighet utifrån ett organisationsteoretiskt perspektiv. Literature Review Sweden Social Work Automated Decision Making ADM Robotic Process Automation RPA Discretion Digital Discretion Street-Level Bureaucracy Social Service Litteraturstudie Sverige socialt arbete automatisering automatiserat beslutsfattande försörjningsstöd handlingsutrymme nyinstitutionell teori RPA Social Work Socialt arbete
36	An investigation into the impact of enterprise architecture decisions on the responsibilities of software developers in companies that develop software Van der Linde, Judith 24 July 2013 (has links) Enterprise Architecture endeavours to resolve the complexity of increasingly distributed systems by aligning business vision with IT strategy, which in turn should reduce the overall costs of IT in the business and provide simpler, better and faster solutions to business problems. There are many Enterprise Architecture frameworks. The main purpose of most of these frameworks is to assist with the challenges of managing the increased complexity of distributed systems, aligning business vision with IT strategy and reducing IT costs. Many of the studies which produced the results stating Enterprise Architecture aligns business vision and reduces IT costs, were based on Zachman’s work, and most of the published Enterprise Architecture success stories focus on the benefits provided to the company with regards to IT. In contrast very little documentation could be found that addresses the impact of Enterprise Architecture implementations on the individuals and systems within a company. If the individuals as the main implementers of any strategy are impacted negatively by Enterprise Architecture management decisions, there would be a negative impact on the return on investment of the company. Enterprise Architecture allows the use of overlapping departments’ processes and data, which translates into less development time as system components would already exist. Changes that are made to the Enterprise Architecture result in several additional changes that had to be implemented by the software developers. These changes influenced the workload, roles and responsibilities of the developers in such a way that the development team became negative about the additional work. The purpose of this study was to investigate the impact of Enterprise Architecture management decisions on the responsibilities, work experience and attitude towards Enterprise Architecture of the software developers in a company that develops software by exploring and describing the nature of software development. Based on the findings of this study, a list of impact of Enterprise Architecture decisions on the responsibilities of software developers in companies that develop software were identified. In this respect, the study identified impacts of Enterprise Architecture management decisions as well as possible solutions to these impacts. / Computing / M. Sc. (Information Systems) Enterprise architecture Software developer SDLC TOGAF Software development companies Impact of enterprise architecture Zachman TOGAF ADM 004.65019 Software architecture Information technology System design Management information systems
37	Spacetime as a Hamiltonian Orbit and Geroch's Theorem on the Existence of Fermions Bergstedt, Viktor January 2020 (has links) Over a century since its inception, general relativity continues to lie at the heart of some of the most researched topics in theoretical physics. It seems likely that the coveted solutions to problems like quantum gravity are to be found in an extension of general relativity, one which may only be visible in an alternate formulation of the theory. In this thesis we consider the possibility of casting general relativity in the form of an initial value problem where spacetime is seen as the evolution of space. This evolution is shown to be constrained and of Hamiltonian type. Not all spacetimes are physically acceptable. To be compatible with particle physics, one would like spacetime to accommodate fermions. Here we can take comfort in Geroch’s theorem, which implies that any spacetime that admits a Hamiltonian formulation automatically supports the existence of fermions. We review the elements that go into the proof of this theorem. / Allmän relativitetsteori har i över hundra år legat i teoretiska fysikens framkant. Det är möjligt att lösningarna på öppna problem som kvantiseringen av gravitation går att finna i en utvidgning av allmän relativitetsteori – och kanske uppenbarar sig denna utvidgning bara ur en alternativ formulering av teorin. I den här uppsatsen formuleras allmän relativitetsteori och dess Einsteinekvationer som ett begynnelsevärdesproblem, genom vilket rumtiden kan betraktas som rummets historia. Vi visar att rummets rörelseekvationer är Hamiltons ekvationer med tvångsvillkor. Enligt partikelfysiken bör fermioner kunna finnas till i rumtiden. Härom kan vi åberopa Gerochs sats, enligt vilken rumtider som har en Hamiltonsk formulering också medger fermioner. Vi redogör för huvuddragen i beviset av Gerochs sats. 3+1 ADM black hole canonical quantization Cauchy surface causality differential geometry Einstein-Hilbert action general relativity Geroch globally hyperbolic Hamilton's equations numerical relativity parallelizable SL(2 C) spacetime spinor spin structure SO(1 3) Stiefel-Whitney class tetrad topology Physical Sciences Fysik
38	Analyse discriminante et perceptron multicouche-liens formels et applications Diagne, Elhadji Diaraff Diegane January 2019 (has links) (PDF) No description available. AD ADF ADL ADM ADP ADQ Algorithme Analyse Application Bruto Classification Discriminant Donnée Fisher Flexible Formel Gaussien HTRU2 Iris Lien Linéaire Mars MclustDA MDA Mélange Multicouche Pénalisé Perceptron PMC Pulsar Quadratique Rétropropagation RFMT Roc Taux TBC TMC
39	An investigation into the impact of enterprise architecture decisions on the responsibilities of software developers in companies that develop software Van der Linde, Judith January 2013 (has links) Enterprise Architecture endeavours to resolve the complexity of increasingly distributed systems by aligning business vision with IT strategy, which in turn should reduce the overall costs of IT in the business and provide simpler, better and faster solutions to business problems. There are many Enterprise Architecture frameworks. The main purpose of most of these frameworks is to assist with the challenges of managing the increased complexity of distributed systems, aligning business vision with IT strategy and reducing IT costs. Many of the studies which produced the results stating Enterprise Architecture aligns business vision and reduces IT costs, were based on Zachman’s work, and most of the published Enterprise Architecture success stories focus on the benefits provided to the company with regards to IT. In contrast very little documentation could be found that addresses the impact of Enterprise Architecture implementations on the individuals and systems within a company. If the individuals as the main implementers of any strategy are impacted negatively by Enterprise Architecture management decisions, there would be a negative impact on the return on investment of the company. Enterprise Architecture allows the use of overlapping departments’ processes and data, which translates into less development time as system components would already exist. Changes that are made to the Enterprise Architecture result in several additional changes that had to be implemented by the software developers. These changes influenced the workload, roles and responsibilities of the developers in such a way that the development team became negative about the additional work. The purpose of this study was to investigate the impact of Enterprise Architecture management decisions on the responsibilities, work experience and attitude towards Enterprise Architecture of the software developers in a company that develops software by exploring and describing the nature of software development. Based on the findings of this study, a list of impact of Enterprise Architecture decisions on the responsibilities of software developers in companies that develop software were identified. In this respect, the study identified impacts of Enterprise Architecture management decisions as well as possible solutions to these impacts. / Computing / M. Sc. (Information Systems) Enterprise architecture Software developer SDLC TOGAF Software development companies Impact of enterprise architecture Zachman TOGAF ADM 004.65019 Software architecture Information technology System design Management information systems
40	Den latinamerikanska (under)representationen : En multimodal textanalys av svenskt läromedel för spanskspråkig undervisning / The (under)Representation of Latin America : A Multimodal Text Analysis of Swedish Textbooks for Spanish Teaching Sellgren, Hanna January 2023 (has links) This study aims to investigate the representation of Latin America in verbal and visual text in Swedish textbooks for Spanish teaching. More specifically, this analysis examines how much of the text is represented by Latin American people in comparison to European people, how Latin Americans are represented and how large the prevalence of each form of representation is, as well as which verbal and visual patterns are present in the textbooks. A quantitative content analysis was used to examine the study's question regarding the extent of the different text forms. The method of the analysis for the remaining questions surrounding the representation of Latin Americans was based on a multimodal critical discourse analysis with a social semiotic approach. The result indicates that Latin Americans comprise a smaller proportion of the extent of text than Europeans. Based on the results of the analysis of representation, the textbooks differed to some extent in the representation of Latin Americans, but the common patterns made visible were that Latin Americans are most often portrayed as impersonal and socially distanced in relation to the recipient. Finally, the result of analysis is problematized in relation to the didactic implications that can be brought about while teaching and the importance of teachers having and teaching critical literacy is highlighted. MCDA multimodal critical discourse analysis textbook analysis social semiotics Latin America representation presence equality Spanish teaching MCDA multimodal kritisk diskursanalys läromedelsanalys socialsemiotik Latinamerika representation förekomst jämlikhet spanskundervisning ADM análisis del discurso multimodal análisis de manuales semiótica social América Latina representación presencia igualdad enseñanza de español Specific Languages Studier av enskilda språk Didactics Didaktik Learning Lärande

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