Submitted by Claudinei Pracidelli (cpracide@ipen.br) on 2015-07-23T11:04:17Z No. of bitstreams: 0 / Made available in DSpace on 2015-07-23T11:04:17Z (GMT). No. of bitstreams: 0 / Os experimentos realizados e apresentados nesta dissertação resultaram na caracterização neutrônica de núcleos na configuração cilíndrica com 30 varetas combustíveis de diâmetro com um espaço, criado pela retirada de 16 varetas centrais, preenchido com água leve (H2O) ou água pesada (D2O) no reator nuclear de pesquisa IPEN/MB-01. Nestes núcleos, efetuou-se experimentos de correlação de canais nucleares, calibração de barras de controle e irradiação de detectores de ativação de diversos materiais em forma de folhas, cujas faixas energéticas de atuação abrangem grande parte do espectro de nêutrons do núcleo do reator, para a obtenção de parâmetros nucleares, como excessos de reatividade, reatividades totais, atividades saturadas por núcleo alvo, razões espectrais, razões de cádmio e fluxo de nêutrons multigrupo. Com a irradiação de fios de ativação de ouro na parte radial foram obtidas as formas espaciais dos fluxos de nêutrons térmicos e epitérmicos. Os resultados mostraram as características espectrais dessa nova configuração com o espaço das 16 varetas combustíveis preenchido com os dois materiais moderadores. No espaço com a água leve houve um aumento significativo de 294% do fluxo de nêutrons térmicos em comparação com a configuração padrão retangular de 28×26 varetas combustíveis. Com a água pesada aumentou-se a reatividade do sistema com ρ = (783 ± 54) pcm a mais de excesso de reatividade que na configuração com água leve. Os resultados calculados foram simulados nos códigos computacionais MCNP5, SANDBP e CITATION, onde se obtiveram resultados acurados e precisos para as atividades saturadas por núcleo alvo, as distribuições energéticas e espaciais dos fluxos de nêutrons da parte ativa e de parte do refletor e as comparações diretas das seções de choque entre as razões espectrais experimentais e calculadas. / Dissertação (Mestrado em Tecnologia Nuclear) / IPEN/D / Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

The national spatial planning guidelines and the subsequent legal regulation in the Natural Resources Act and the Environmental Code has been a part of the Swedish planning system for almost 40 years. In the recent years, critics have claimed that the regulations are outdated and does not work the way it was intended. This paper examines closer why it is perceived that the regulations does not work, with a focus on how the national interests are managed in the municipal planning. Why is the national interests not applied in the municipal planning as intended? Is the error in the system or in the implementation of it? The aim of this essay is to study the gap between theory and practice by studying how the land management provisions in the Environmental Code is applied in five selected municipalities. The aim is also to find interesting issues for futher studies of the topic. The problem is specified as the differense between how the legal clauses are applied and how they were intended to be applied. Amongst other aspects, the essay studies how the organisation of the municipality and the political governing affects the practice. Three methods is used. Intervention theory is used to interpret the the Environmental Code’s land management provisions, comparative analysis to identify factors which are likely to affect the municipal planning and qualitative inteview to attain deeper knowledge about how the planning is implemented in the municipalities. The land management provisions of the Environmental Code’s 3 and 4 chapters can be traced directly to the national spatial planning during the 70’s and 80’s. Since the national spatial planning until today, several system models have been used to visualize the procedure and coordination between different public agencies. In chapter 5 an intervention theory is summarized and two new models are created. Chapter 6 descibes how the five selected municipalities have specially accounted for the national interest in the comprehensive plan. Three factors are studied; how the national interests are accounted for in the comprehensive plan; if all land management provisions are accounted for; and if the municipality describes how they intend to protect the national intresets from palpable damage. The study shows that three of the municipalities specially account for the national interests in a seperated chapter or annex. Two of the municipalities acount for all management provisions and three of the municipalites descibes at least one of the protection of the national intrerest in detail. Thus, two of the municipalities are assessed to have a complete knowledge base in the comprehensive plan for continuing working with the national intrerest in detailed planning and building permit processing. (94) 7 In chapter 7 a number of factors which are believed to affect the municipalities way of account for the national interests are compared through comparative analysis. Factors such as population, access to enhanced knowledge base from a national agency and political governance is studied and compared between the municipalities. Chapter 8 presents interviews with officals and politicians in the selected municipalities and county administration. From the interviews a number of interesting topics are detected. A good knowledge and planning base is very important for the municipal planning, and the comprehensive plan is important for the land management provisions to work the way they were intended. Chapter 9 presents the conclusion of the essay. The first conclusion is that there are a lack of guidelines in the municipalities’ comprehensive plans for how to process detailed plans and building permits in areas of national interest. The second conclusion is that some national interests are descibed better than others in the comprehensive plan. The third conclusion is that the couty board is affecting the way the municipalities view the national interests. / Den fysiska riksplaneringens riktlinjer och den senare lagregleringen av dem i NRL och MB har varit en del av det svenska planeringssystemet i snart 40 år. De senaste åren har kritik riktats mot att systemet är föråldrat och inte fungerar på det vis det var tänkt. Denna uppsats undersöker närmare uppfattningen av att hushållningsbestämmelserna inte fungerar, med fokus på hur man i den kommunala planeringen hanterar riksintressena. Varför fungerar inte planeringen av riksintressena som tänkt? Ligger felet i systemet eller i tillämpningen av det? Syftet med denna uppsats är att studera vad som orsakar glappet mellan teori och praktik, genom att studera hur hushållningsbestämmelserna tillämpas i fem utvalda kommuner. Syftet med studien är också att hitta intressanta frågeställningar för vidare studier av ämnet. Problemet preciseras till skillnaden mellan tillämpningen av lagstiftningen och hur det var tänkt att tillämpas. I uppsatsen studeras bland annat hur kommuners organisation och politiska styrning påverkar tillämpningen. Tre metoder används. Interventionsteori för att tolka hushållningsbestämmelserna, komparativ analys för att identifiera faktorer som kan påverka kommunernas arbete med riksintressen och kvalitativ intervju för att uppnå fördjupad kunskap om kommunernas arbete. Hushållningsbestämmelserna i miljöbalkens 3 och 4 kapitel kan härledas direkt till riksplaneringen under 70- och 80-talet. Naturresurslagen trädde i kraft 1987, och hushållningsbestämmelserna överfördes oförändrade till Miljöbalken 1998. Flera modeller har används för att visualisera hur samordningen mellan myndigheterna ska ske, både under fysiska riksplaneringen och under senaste året. I kapitel 5 sammanfattas interventionsteorin och två systemmodeller konstrueras. I kapitel 6 beskrivs hur kommunernas särskilda redovisning av riksintressen i översiktsplanen. Tre faktorer studeras: hur riksintressena redovisas; om samtliga hushållningsbestämmelser redovisas; om kommunen beskriver hur säkerställandet av riksintresseanspråken ska ske. Studien av översiktsplanerna visar att tre av kommunerna redovisar riksintressen i ett särskilt kapitel eller bilaga. Två av kommunerna redovisar samtliga hushållningsbestämmelser och tre av kommunerna beskriver säkerställandet av åtminstone något riksintresse mer utförligt. Två av kommunerna bedöms ha ett i huvudsak fullständigt underlag i översiktsplanen för att arbeta vidare med riksintressen i planeringen och bygglovshandläggning. I kapitel 7 jämförs kommunerna i ett antal faktorer som tros påverka hur kommunen redovisat riksintressen i översiktsplanen. (94) 5 Faktorer som invånarantal, tillgång till fördjupat kunskapsunderlag och politisk styrning studeras och jämförs mellan kommunerna. I kapitel 8 redovisas intervjuer med tjänstemän och politiker i de studerade kommunerna samt de berörda länsstyrelserna. Från intervjuerna identifieras ett antal teman som viktiga att belysa. Kunskaps- och planeringsunderlaget är mycket viktigt för kommunernas planering, och översiktsplaneringen är viktig för att riksintressesystemet ska fungera. I kapitel 9 redovisas slutsatser. Slutsatsen är att det finns brister i kommunernas översiktsplaner när det gäller översiktsplanen som vägledande dokument för hur kommunen ska arbeta med områden av riksintresse i detaljplanering och bygglovshandläggning; att det finns skillnad i hur utförligt de olika riksintressena redovisas; att den kommunala organisationen kan påverka hur väl riksintressen redovisas och att det kan finnas samband mellan hur länsstyrelsen presenterar sin roll och hur kommunerna ser på sin roll.

Magister Scientiae (Medical Bioscience) - MSc(MBS) / Purpose: Breast cancer is one of the most frequent and fatal diseases women all around the globe are challenged with today. In women, breast cancer has the highest mortality rate of all cancers and the incidence rate is on the increase. It is estimated that by the year 2025, 19.3 million women will become a victim of this grave health problem. This disease is a result of the formation of malignant tumours caused by genetic alterations that are involved in the proliferation of cells, cellular differentiation and the disturbance in homeostasis which subsequently leads to the abnormal multiplication and growth of cells. Breast cancer is considered a multifactorial disease with various risk factors such as age, radiation exposure, hormone therapy, oral contraceptives, dietary factors, environmental exposure and genetic predispositions. Breast cancers can be subdivided and classified based on their cellular surface receptors such as Estrogen Receptors, Progesterone Receptors and Human Epidermal Growth Factor Receptor 2. Of the various subtypes, the triple-negative breast cancer subtype which is negative for all 3 surface receptors and presents as the most aggressive form of breast cancer with a poor prognosis. Between 10-20% of all breast cancer cases are classified as triple-negative breast cancer. Due to the hormonal status of triple-negative breast cancer, treatment options are limited and thus of great concern. Chemotherapy remains the most common treatment modality, but prognosis is poor with relapse within years ultimately leading to poor survival outcome. Due to this lack of effective treatment plans, an alternative treatment with minimal side effects and better survival remains an imperative area to explore. A wide scope of literature highlights red palm oil and its health benefits, with its growth inhibitory potential drawing great attention. Red palm oil, extracted from the Elaeis guineensis palm tree is red in colour due to the abundance of carotenoids, tocotrienols and tocopherols found in the oil. Various compounds make up the oil such as lycopene, carotenes, vitamin E and coenzyme Q10. Most studies have researched the effects of vitamin E extracted from the oil as a contributor to its growth inhibitory activity. This study focuses on the effects of the commercial red palm oil as a whole with all its compounds on the proliferation of breast cancer cells as well as the effect it has on various genes associated with breast cancer. Method: This study investigated the effect of red palm oil concentrations (1, 10, 100, 500 and 1000 μg/ml) on breast cancer cells—MCF-7 and MDA-MB-231 with comparison to a non-cancerous cell line—MCF-12A for 24-, 48- and 72-hour treatment periods. The parameter investigated was cell proliferation through the CCK-8 cell proliferation assay and the morphology following red palm oil treatment was observed and captured. Additionally, this study also investigated the effect of red palm oil on the expression of Human Mammaglobin (hMAM) and Maspin genes through the PCR assay and results visualised through agarose gel electrophoresis. Data was statistically analysed using GraphPad version 6.0 software. Results: Following treatment of red palm oil, no apparent changes in the cell morphology was observed despite using variable treatment concentrations over variable times for MCF-7, MDA-MB-231 and MCF-12A cells relative to their respective controls. Immortalised MCF-12A cells showed a significant increase in proliferation with the varying treatment concentrations, but more prominently with the highest concentration at 24, 48 and 72 hours. MCF-7 cells showed significant decreases at 24 and 72 hours. Decreased proliferation was observed at all dosages used, particularly at 10, 100, and 500 μg/ml. Furthermore, MDA-MB-231 cells demonstrated a gradual increase in cell proliferation for the 3 selected time periods in the varying concentrations. Additionally, red palm oil did not alter the gene expression of Maspin at any of the varying treatments for MDA-MB-231 nor MCF-7 cells. However, changes in hMAM gene expression were observed at treatment concentration of 100 μg/ml in MDA-MB-231 cells that were incubated for 24 and 48 hours. However, the hMAM expression was not affected in treated MCF-7 cells. Conclusion: Red palm oil, as an alternative dietary oil, seems to have potential growth inhibitory properties as demonstrated by the change in the cell proliferation of the MCF-7 cells. Literature show that various individual compounds extracted from red palm oil have anti-proliferative and inhibitory effects on breast cancer cells making them good candidates for therapy. However, this study concludes that red palm oil as a whole component would not be a suitable therapeutic agent for highly aggressive triple-negative breast cancer.

De svenska miljömålen är framtagna till följd av Agenda 2030 och de globala målen som FN har beslutat om. Miljömålen ska verka som den centrala utgångspunkten i det allmänna arbetet med miljöfrågor i samhället. Giftfri miljö är en av de 16 framtagna miljökvalitetsmål, inom den fysiska planeringen innebär detta främst ett arbete med förorenad mark vid exploatering och stadsomvandling. De senaste årens ökade urbanisering samt viljan att förtäta våra städer, gör att många kommuner omvandlar äldre industriområden och industrihamnar till bostadsområden. Följderna blir att frågor kring föroreningar blir allt vanligare i planeringsprocessen. Arbetet med att farliga ämnen inte ska utgöra något hot mot människors hälsa och miljö kräver ofta ett brett samarbete. Detta sker såväl mellan konsulter, länsstyrelser och statliga förvaltningar, som förvaltningsövergripande inom en kommun. Vägen från politiskt beslut till genomförande i praktiken är lång och det är många parter som ska bidra med sin del under vägens gång. Författaren har i denna uppsats undersökt implementeringsprocessen av miljömålet Giftfri miljö, med ett fokus på förorenad mark. Detta har utförts genom fallstudier av två planeringsprojekt i två olika kommuner, Kilströmskaj i Karlskrona kommun samt kvarteret Kilen i Ronneby kommun. Empirin som har granskats är kommunala antagandehandlingar samt markutredningar utförda av konsultföretag. För att studera empirin har argumentationsanalys använts, för att sedan analysera resultatet och kunskapsöversikten utifrån ett implementeringsteoretiskt perspektiv. Generellt sätt så kan implementeringen av miljömålet Giftfri miljö, utifrån denna fallstudie, anses som en fungerande process men med möjlighet till förbättring. Trots en fungerande implementering så kommer vi, i dagens takt, inte uppnå miljömålet. De huvudsakliga aspekterna som är i behov av bearbetning och förtydligande är prioriteringsordning vid statligt bidrag samt avvägandet mellan sociala, ekologiska och ekonomiska aspekter. Undersökningen visar också på ett behov kring tydligare vägledning för planerare på kommunal nivå.

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Uma nova metodologia para a medida absoluta da fração efetiva de nêutrons atrasados βeff, baseada em técnicas de análise de ruído microscópico e no modelo de Duas- Regiões, foi desenvolvida no reator IPEN/MB-01. Diferentemente das demais técnicas, tais como o Método de Bennet Modificado, o Método do Número de Nelson e o Método da fonte de 252Cf, a principal vantagem da metodologia proposta é a obtenção de βeff de um modo puramente experimental, sem a necessidade de quaisquer outros parâmetros, sejam estes calculados ou provenientes de outros experimentos. Com a finalidade de validar este novo método, uma série de experimentos Rossi-α e Feynman-α foram realizados no reator IPEN/MB-01. De acordo com a metodologia proposta, βeff foi estimado com uma incerteza de 0.67%, a qual atende aos requisitos de precisão almejados. Além disso, o tempo de geração de nêutrons prontos , dentre outros parâmetros, também foi obtido experimentalmente via esta metodologia. Em geral, os parâmetros medidos estão em acordo com resultados provenientes de experimentos de análise de ruído macroscópico. Nas comparações teoria-experimento, os valores de βeff medidos neste trabalho mostram que a biblioteca JENDL3.3 apresenta a melhor performance (dentro de 1%). Esta concordância justifica a redução no yield de fissão do 235U proposta por Sakurai e Okajima. / A new method for absolute measurement of the effective delayed neutron fraction, βeff , based on microscopic noise experiments and the Two-Region Model was developed at the IPEN/MB-01 Research Reactor facility. In contrast with other techniques like the Modified Bennet Method, Nelson-Number Method and 252Cf-Source Method, the main advantage of this new methodology is to obtain the effective delayed neutron parameters in a purely experimental way, eliminating all parameters that are difficult to measure or calculate. In this way, Rossi-α and Feynman-α experiments for validation of this method were performed at the IPEN/MB-01 facility, and adopting the present approach, βeff was measured with a 0.67% uncertainty. In addition, the prompt neutron generation time, , and other parameters were also obtained in an absolute experimental way. In general, the final results agree well with values from frequency analysis experiments. The theory-experiment comparison reveals that JENDL-3.3 shows deviation for βeff lower than 1% which meets the desired accuracy for the theoretical determination of this parameter. This work supports the reduction of the 235U thermal yield as proposed by Okajima and Sakurai.

Uma nova metodologia para a medida absoluta da fração efetiva de nêutrons atrasados βeff, baseada em técnicas de análise de ruído microscópico e no modelo de Duas- Regiões, foi desenvolvida no reator IPEN/MB-01. Diferentemente das demais técnicas, tais como o Método de Bennet Modificado, o Método do Número de Nelson e o Método da fonte de 252Cf, a principal vantagem da metodologia proposta é a obtenção de βeff de um modo puramente experimental, sem a necessidade de quaisquer outros parâmetros, sejam estes calculados ou provenientes de outros experimentos. Com a finalidade de validar este novo método, uma série de experimentos Rossi-α e Feynman-α foram realizados no reator IPEN/MB-01. De acordo com a metodologia proposta, βeff foi estimado com uma incerteza de 0.67%, a qual atende aos requisitos de precisão almejados. Além disso, o tempo de geração de nêutrons prontos , dentre outros parâmetros, também foi obtido experimentalmente via esta metodologia. Em geral, os parâmetros medidos estão em acordo com resultados provenientes de experimentos de análise de ruído macroscópico. Nas comparações teoria-experimento, os valores de βeff medidos neste trabalho mostram que a biblioteca JENDL3.3 apresenta a melhor performance (dentro de 1%). Esta concordância justifica a redução no yield de fissão do 235U proposta por Sakurai e Okajima. / A new method for absolute measurement of the effective delayed neutron fraction, βeff , based on microscopic noise experiments and the Two-Region Model was developed at the IPEN/MB-01 Research Reactor facility. In contrast with other techniques like the Modified Bennet Method, Nelson-Number Method and 252Cf-Source Method, the main advantage of this new methodology is to obtain the effective delayed neutron parameters in a purely experimental way, eliminating all parameters that are difficult to measure or calculate. In this way, Rossi-α and Feynman-α experiments for validation of this method were performed at the IPEN/MB-01 facility, and adopting the present approach, βeff was measured with a 0.67% uncertainty. In addition, the prompt neutron generation time, , and other parameters were also obtained in an absolute experimental way. In general, the final results agree well with values from frequency analysis experiments. The theory-experiment comparison reveals that JENDL-3.3 shows deviation for βeff lower than 1% which meets the desired accuracy for the theoretical determination of this parameter. This work supports the reduction of the 235U thermal yield as proposed by Okajima and Sakurai.

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