Philip Doddridge (1702-51) was pastor of the Independent congregation meeting at Castle Hill, Northampton, and tutor of the Northampton academy from 1729 to his death in 1751. He is regarded as a leader of moderate Dissent during that period and the heir, theologically and pastorally, of Richard Baxter. He has been seen as forming a bridge between the more rational Dissenters, on the one hand, and the more conservative and orthodox wing of Dissent on the other. His thought has not, however, been the subject of a detailed analysis in the context of his time. This thesis sets out to conduct such an analysis in order to examine more closely his position within early eighteenth-century Dissent. Doddridge’s philosophical and theological views are considered in chapters two to five. Chapter two assesses the extent of his indebtedness to the philosophy of John Locke, examining also the views of Isaac Watts and showing how Doddridge and Watts modified Locke’s thought in some areas in order to accommodate Christian beliefs. In chapter three, Doddridge’s views on natural theology, natural law and reason are considered and the influence on him of Samuel Clarke, in particular, is examined. Turning to theology, chapter four looks at the use in early eighteenth-century Dissent of terms such as ‘Baxterian’ and ‘moderate Calvinist’ and then considers Doddridge’s doctrinal positions on a range of subjects which are generally considered to represent Baxterian theology. Chapter five examines Doddridge’s views on the key interconnected areas of confessional subscription, scripture and the doctrine of the Trinity. Practical subjects are then considered in chapters six to eight. Doddridge’s views on Christian piety are examined in chapter six. Chapter seven considers ways in which Doddridge sought to communicate, examining the audiences whom he aimed to reach, the ways in which he attempted to reach them and the content of what he wanted to say. The eighth chapter looks at the subject of identity and argues that Doddridge is to be viewed, not so much as a bridge between different wings of Dissent, but as a leader amongst moderate Calvinists. In conclusion, this thesis argues that Philip Doddridge sought to expound a Calvinist theology in the context of the philosophical and theological debates of his day and to promote an ordered Dissent focused on central evangelical truths and united around the language of scripture.

Au Québec, face à la prévalence élevée des problèmes de santé mentale et à la pénurie de médecins psychiatres, le médecin omnipraticien (MO) occupe une place primordiale dans la prise en charge et le suivi des soins de santé mentale. Dans le contexte de réforme du système de santé mentale axée sur un renforcement de la collaboration entre les MO, les psychiatres et les équipes de santé mentale, notre étude vise à mieux comprendre la pratique clinique et la pratique collaborative développée par les MO, leur appréciation des outils de travail et de la qualité des services de santé mentale, dans le but d’améliorer la complémentarité des soins au niveau primaire. Cette étude transversale impliquait 1415 MO de neuf territoires de centre de santé et de services sociaux (CSSS) du Québec. L’échantillon final était constitué de 398 MO représentatifs de lieux de pratique diversifiés et le taux de réponse était de 41%. Nos résultats mettent en évidence que la pratique clinique et la pratique collaborative des MO diffère selon le degré de gravité des problèmes de santé mentale des patients rencontrés, c’est à dire, trouble transitoire/modéré de santé mentale (TTM.SM) ou trouble grave de santé mentale (TG.SM), et que les MO sont favorables au fait de travailler en collaboration avec les autres professionnels de la santé mentale. Ainsi, il apparaît important de renforcer l’accessibilité des MO aux professionnels de la santé mentale, particulièrement les psychiatres, et de les informer de l’existence des autres acteurs en santé mentale sur leur territoire, pour renforcer la collaboration et la qualité des soins primaires de santé mentale. / In Quebec, considering the high prevalence rate of mental health disorder and the scarcity of psychiatrists, general practitioners (GPs) hold an importante role in the management and the follow-up of mental health care. In the context of the ongoing mental health system reform aimed at reinforcing collaboration between GPs, psychiatrists and mental health teams, our objectives are to have a better understanding of clinical practice and collaborative practice, developed by GP and their assessment of working tools and quality of mental health services, in order to improve the complementary of primary mental health care. The study was carried out using a cross-sectional design, involving 1415 GPs from nine Quebec territories. The final sample included 398 GPs, representing diverse practice places, and the response rate was 41%. The study highlighted that GPs have different clinical and collaboration practices according to the seriousness of mental disorder patients seen, i.e. transient and moderate mental disorder (TMMD) or serious and permanent mental disorder (SPMD); and GPs strongly support care coordination efforts with all mental health professionals. Therefore, it appears important to reinforce GP accessibility to other mental health professionals, particularly psychiatrists, and to inform them on the presence of all actors in mental health in their territory, in order to develop collaboration and quality of primary mental healthcare.

<p>This research assessed landuse changes and trends in vegetation cover in the Sandveld, using remote sensing images. Landsat TM satellite images of 1990, 2004 and 2007 were classified using the maximum likelihood classifier into seven landuse classes, namely water, agriculture, fire patches, natural vegetation, wetlands, disturbed veld, and open sands. Change detection using remote sensing algorithms and landscape metrics was performed on these multi-temporal landuse maps using the Land Change Modeller and Patch Analyst respectively. Markov stochastic modelling techniques were used to predict future scenarios in landuse change based on the classified images and their transitional probabilities. MODIS NDVI multi-temporal datasets with a 16day temporal resolution were used to assess seasonal and annual trends in vegetation cover using time series analysis (PCA and time profiling).Results indicated that natural vegetation decreased from 46% to 31% of the total landscape between 1990 and 2007 and these biodiversity losses were attributed to an increasing agriculture footprint. Predicted future scenario based on transitional probabilities revealed a continual loss in natural habitat and increase in the agricultural footprint. Time series analysis results (principal components and temporal profiles) suggested that the landscape has a high degree of overall dynamic change with pronounced inter and intra-annual changes and there was an overall increase in greenness associated with increase in agricultural activity. The study concluded that without future conservation interventions natural habitats would continue to disappear, a condition that will impact heavily on biodiversity and significant waterdependent ecosystems such as wetlands. This has significant implications for the long-term provision of water from ground water reserves and for the overall sustainability of current agricultural practices.</p>

Dans les cellules somatotropes, la liaison du facteur de libération de l’hormone de croissance (GHRH) à son récepteur (GHRH-R) stimule la synthèse et la sécrétion de l’hormone de croissance (GH) ainsi que la prolifération cellulaire. Chez les mammifères, le vieillissement est caractérisé par une diminution de la sécrétion de GH, liée à une perte de sensibilité des somatotropes au GHRH. Chez le rat âgé, des modifications de niveaux d'ARNm du GHRH-R et une diminution d'affinité et de capacité de liaison du GHRH sont rapportés. Au cours du vieillissement, une augmentation des niveaux de glucose et d’acides gras libres sérique suggère qu’une gluco- ou lipotoxicité puisse contribuer au dysfonctionnement de la fonction somatotrope. À ce jour, la restriction calorique modérée de longue durée (RCMLD) constitue l’intervention la plus efficace pour prévenir ou retarder les détériorations liées à l’âge. Des études ont montré des effets bénéfiques de la RCMLD sur l’axe somatotrope au cours du vieillissement via un maintien des paramètres de liaison du GHRH-R. Compte tenu de l’importance de cet axe, la compréhension des mécanismes menant à la somatopause ainsi que ceux associés aux effets bénéfiques de la RCMLD s’avère importante. Les objectifs principaux de la présente thèse étaient : 1) de déterminer les effets de la RCMLD chez le rat, sur le GHRH-R hypophysaire et la sensibilité des somatotropes au GHRH, 2) d’identifier les mécanismes associés à la somatopause et aux effets bénéfiques de la RCMLD, et 3) de préciser les effets d’une gluco-ou lipotoxicité sur l’axe somatotrope de rats et leur implication dans la somatopause. Des rats de 8 mois ont été soumis à une restriction calorique de 40% jusqu’à l’âge de 18-20 mois et ont été comparés à des rats jeunes et âgés nourris ad libitum. Cette étude a permis de mettre en évidence des effets bénéfiques de la RCMLD sur la régulation et la fonctionnalité du GHRH-R et de proposer que le glucose et les acides gras libres (AGL) circulants soient impliqués dans le vieillissement de la somatotrope. Une étude de micro-puce à ADN à permis d’identifier des gènes associés à des mécanismes de protection et de réparation des dommages cellulaires mis en place dans l’hypophyse antérieure au cours du vieillissement et par la RCMLD. Finalement, les effets d’un stress gluco- ou lipotoxique sur la fonction somatotrope ont été étudiés chez des rats de 2 et 6 mois, infusés 72 h avec une solution de glucose ou d’Intralipides, mimant les niveaux circulants de glucose et d’AGL retrouvés chez le rat âgé. Les résultats obtenus montrent que la glucotoxicité affecte la régulation de certains gènes de la somatotrope, dont le GHRH-R, et suggèrent que la capacité de réponse à ce type de stress est altérée. Les mécanismes par lesquels la glucotoxicité exerce ces effets pourraient inclure la génération de stress oxydant. L’ensemble de ces résultats proposent de nouvelles pistes mécanistiques qui pourraient contribuer au retardement de la somatopause et, ultimement, à l’élaboration de nouvelles stratégies d’intervention nutritionnelles ou pharmacologiques ciblant les mêmes voies que la RCMLD, avec une efficacité similaire ou supérieure. / In somatotroph cells, growth hormone-releasing hormone (GHRH) binding to its receptor (GHRH-R) stimulates growth hormone (GH) secretion and cell proliferation. In mammals, aging is characterized by a decrease of GH, associated with a decline of GHRH somatotroph sensitivity. In the aged rat, changes in GHRH-R mRNA levels and decrease of GHRH affinity and capacity were reported. In the course of aging, significant increase of glucose and free fatty acid (FFA) serum levels are observed, suggesting that gluco- or lipotoxicity could contribute to somatotroph dysfunction. Up to now, long-term moderate caloric restriction (LTMCR) has been the most efficient intervention to prevent or delay age-related deteriorations. Studies have shown beneficial effects of LTMCR on somatotroph axis during aging, through the maintenance of GHRH-R binding parameters. Knowing the importance of this axis, an understanding of the mechanisms associated with the effects of somatopause and benefits of LTMCR is important. Therefore, the main objectives of this thesis were: 1) to determine the effects of LTMCR on rat pituitary GHRH-R and somatotroph sensitivity to GHRH, 2) to identify the mechanisms associated to somatopause and the beneficial effects of LTMCR and 3) to specify the effect of gluco- or lipotoxicity on the rat somatotroph axis and their implications in somatopause. Eight-month-old rats were submitted to a 40% LTMCR until the age of 18 to 20-months and where compared to young and old rats fed ad libitum (AL). This study highlighted beneficial effects of LTMCR on GHRH-R regulation and functionality and suggested that high circulating levels of glucose and FFA could be involved in somatotroph aging. A microarray study was also performed, allowing the identification of genes associated to cellular protection and damage repair mechanisms regulated by aging and LTMCR in the anterior pituitary. Finally, effects of a gluco- or lipotoxic stress on the somatotroph function was assessed in 2- and 6-month-old rats submitted to a 72-h glucose and/or Intralipid infusion, to mimic the levels of glucose and FFA found in aged rats. The results showed that glucotoxicity affects the regulation of specific genes in the somatotroph, such as the GHRH-R gene, and suggest that the response capacity against this type of stress is altered with age very early on. Mechanisms by which glucotoxicity exerts these effects might include oxidative stress production. Altogether, these results proposed novel mechanisms that could contribute to delay somatopause and, ultimately, to the development of new nutritional or pharmacologic interventions targeting the same pathways as LTMCR, with a similar or greater efficiency.

No description available.

Submitted by Viviane Lima da Cunha (viviane@biblioteca.ufpb.br) on 2016-05-06T13:20:07Z No. of bitstreams: 1 arquivototal.pdf: 2988550 bytes, checksum: bb61f478d61d75baec8e92e0e6b9470f (MD5) / Made available in DSpace on 2016-05-06T13:20:07Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 2988550 bytes, checksum: bb61f478d61d75baec8e92e0e6b9470f (MD5) Previous issue date: 2015-02-24 / Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq / It is known that ethanol present in the alcoholic beverages, of acute or chronic ingestion in its various levels, leave to a variety of organic alterations that can interfere with more basic behavioral and cognitive processes. In this sense, the present study aimed to evaluate the influence of acute and chronic ethanol intake in the auditory perception and neuropsychological functioning. Acute ingestion was experimentally manipulated in college students with 18 to 30 years old compared with themselves in two different sessions. In one of days, they had to ingest a quantity of alcohol proportional to their body weight and when they possessed 0.08% of ethanol in the blood they were evaluated. In another day, they drank just a placebo drink. The chronic ingestion of alcohol was evaluated in Alcoholics Anonymous participants, aged 40-60 years, who had 1-15 years of abstinence. They were evaluated in separate groups of three years of abstinence and were compared to a control group of first degree relatives. The auditory perception was evaluated by means of a test for discrimination of musical notes corresponding to standard Western scale sound frequencies. Cognitive functioning was evaluated by means of neuropsychological tests for the processes of memory, attention, and executive functioning. The results showed that both forms of alcohol intake cause perceptual hearing loss as well as the some neuropsychological subfunctions evaluated, suggesting that the use of ethanol may be a path of some cognitive impairment. / Sabe-se que o etanol, presente nas bebidas alcoólicas, ingerido de forma aguda ou crônica, em seus vários níveis, leva a uma série de alterações orgânicas que podem interferir em processos cognitivos e comportamentais básicos. Nesse sentido, o presente estudo teve como objetivo avaliar a influência da ingestão aguda e crônica de etanol na percepção auditiva e no funcionamento neuropsicológico. Manipulou-se a ingestão aguda em estudantes universitários, de 18 a 30 anos, os comparando consigo mesmos em duas condições diferentes. Em uma delas, solicitava-se que os participantes ingerissem uma quantidade de álcool proporcional ao seu peso corporal para que no momento dos testes possuíssem 0,08 % de etanol no sangue. Na outra, ingeriam apenas uma bebida placebo. Avaliou-se a ingestão crônica do álcool em participantes de Alcoólicos Anônimos, com idades de 40 a 60 anos, que possuíam de 1 a 15 anos de abstinência, sendo que se avaliaram estes em grupos separados pelo tempo de três anos de abstinência em comparação a um grupo controle formado por parentes em primeiro grau. Avaliou-se a percepção auditiva por meio de um teste de discriminação de frequências sonoras correspondentes às notas musicais de um escala ocidental padrão. Já o funcionamento cognitivo avaliou-se por meio de testes neuropsicológicos relativos aos processos de memorização, atenção, e de funcionamento executivo. Os resultados mostraram que ambas as formas de ingestão do álcool ocasionam prejuízos perceptivos na audição, bem como em algumas das subfunções neuropsicológicas avaliadas, sugerindo que o uso do etanol pode ser um demarcador de determinadas deficiências cognitivas.

The Social Democratic Party and the Moderate Party are two parties with different ideological background. The parties have different opinions in issues of public and private matters. The Social Democratic Party profiles it self, through the local and national party programs, as a party for solidarity and security. The Moderate Party, on the other hand, profiles it self through their programmes as a party with a possibility for the individual to shape his or her own life. Through a survey on members in the local government, and two key persons at national level, the view of municipal self-government has appeared. The party programmes constitute a platform for the parties´ views on municipal self-government. These views have been put together with the result of the survey. Urban Strandberg has designed an analysis frame related to municipal self-government. His concept, municipalities’ basic character, board of directors and administration, is the theoretical foundation of the thesis. The content of the Party programmes and the results of the survey are thendiscussed within the frame of Strandbergs concept and Demokratiutredningens rapport SOU 2000:1. From the collective perspective of the theory, the content of party programmes and the result of the survey an image of the parties’ views on municipal self-government starts to grow. Within each party respectively, they keep a common strategy in important issues, which the local governments and the parties’ basic characters have raised. There are dividing lines due to the administration of the municipalities. Civic participation unites the parties in ideological issues. The opinions, in the issue of municipal self-government, differs between the Social Democratic Party and the Moderate Party. The reason for that is because of their fundamental different views in the fields of social order and ideology, as it is described in the party programmes. In reality when the parties shape the politics they cannot profile themselves as much as in the"vision"in their party programmes. The parties have to find a middle course, which is reflected in the answers from some of the respondents.

Magister Scientiae (Biodiversity and Conservation Biology) - MSc (Biodiv and Cons Biol) / This research assessed landuse changes and trends in vegetation cover in the Sandveld, using remote sensing images. Landsat TM satellite images of 1990, 2004 and 2007 were classified using the maximum likelihood classifier into seven landuse classes, namely water, agriculture, fire patches, natural vegetation, wetlands, disturbed veld, and open sands. Change detection using remote sensing algorithms and landscape metrics was performed on these multi-temporal landuse maps using the Land Change Modeller and Patch Analyst respectively. Markov stochastic modelling techniques were used to predict future scenarios in landuse change based on the classified images and their transitional probabilities. MODIS NDVI multi-temporal datasets with a 16day temporal resolution were used to assess seasonal and annual trends in vegetation cover using time series analysis (PCA and time profiling).Results indicated that natural vegetation decreased from 46% to 31% of the total landscape between 1990 and 2007 and these biodiversity losses were attributed to an increasing agriculture footprint. Predicted future scenario based on transitional probabilities revealed a continual loss in natural habitat and increase in the agricultural footprint. Time series analysis results (principal components and temporal profiles) suggested that the landscape has a high degree of overall dynamic change with pronounced inter and intra-annual changes and there was an overall increase in greenness associated with increase in agricultural activity. The study concluded that without future conservation interventions natural habitats would continue to disappear, a condition that will impact heavily on biodiversity and significant waterdependent ecosystems such as wetlands. This has significant implications for the long-term provision of water from ground water reserves and for the overall sustainability of current agricultural practices. / South Africa

This study uses variables derived from Rational Choice Theory to examine the theory’s predicted covariancebetween public opinion and the parties’ policies. The collection of material has been guided by three arenas: the parliamentarian, the media and the voter’s. It has categorized the analysis based on the strategy concept, using ends, means and ways. It asks how the Moderate Party and the Social Democratic Party changed their strategy within the period of 31 May 2013 and 14 September 2014, and how this can be understood from a rational choice perspective. The purpose of the study is to examine the assumptions of Rational Choice Theory in the Swedish context in front of the election in 2014, and to understand this from the perspective of the theory. This can help in our understanding of defense policy formation and to our understanding of states’ relations on the international arena. The results show that there has been a more ambitious change in defense policy which covariates with the indicated positive change in public opinion on defense issues, but this did not make defense issues one of the 2014 election’s most important questions for the voters in choice of party to vote for. This can be understood as rational, seen from a RCT-perspective, since the other issues renders more support, a circumstance that is in line with the history of Swedish elections.

Title: Similarities or differences within the centre-right? A study of the potential for party fusions within in the Swedish centre-right Author: Charlie Weimers Aim: The thesis seeks to find the potential for party fusions within the Swedish centre-right by analyzing the ideological similarities and differences between the parties. Method/Material: In the thesis, four dimensions of the parties’ ideologies are analyzed: view of man, theory for societal structures, fiscal theory and moral values. The results of the study of the ideologies are then compared. The investigation is done with the party manifestos as starting point and with the analysis of ideas as theoretical tool. Main Results: The comparative analysis, based on the parties’ ideological views, shows specific party constellations are more probable than others. The biggest ideological similarities are to be found between the Liberal People’s Party and the Centre Party, out of which I conclude that these two parties have the best potential for a fusion. The Moderate Party and the Christian Democratic Party also have clear similarities, thus there is a potential for fusion to a certain degree. The Moderate Party also shows some similarities with the Liberal People’s Party and the Centre Party, hence the possibility for a merger can not be excluded. My conclusion is based upon social liberalism and neo-conservatism as ideal types, which gives the Christian Democratic Party a position to the right. Thus, it would possible to claim that this party has the least options regarding fusion partners. The Moderate Party has the most alternatives, since the party is in a kind of “middle ground” between social liberalism and neo-conservatism. Number of pages: 49 Course: Political Science C University: Faculty of Social and Life Sciences, Karlstad University Period: Fall, 2006 Tutor: Anders Broman Keywords: centre-right, Sweden, party fusion, ideology, Moderate Party, Liberal People’s Party, Christian Democratic Party, Centre Party