Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal

Syfte: Studien har två syften: Att beskriva förekomsten av kategorier och omfattningen av frivillig redovisning om anställda som är relaterad till bolagens sociala ansvar (CSR). Att förklara vilka faktorer som påverkar omfattningen av frivillig redovisning relaterat till anställda.  Metod: Då studien har ett förklarande syfte som berör omfattningen av frivillig redovisning om anställda, så har kvantitativa metoder använts och data till studien har samlats in via en kvantitativ innehållsanalys. Studien utfördes på 56 av de 58 bolag som befann sig på Large Cap, Stockholmsbörsen 2012, varav två bolag fick räknas som bortfall på grund av andra redovisningssätt än de övriga. Datat analyserades sedan genom deskriptiv statistik och multipla regressionsanalyser.  Resultat & slutsats: Stora bolag på Stockholmsbörsen redovisar frivilligt multipla kategorier information om anställda, men den kategori som generellt används mest är profilinformation om anställda. Den faktor som främst förklarar den frivilliga informationen om anställda är bolagets skuldkvot, men också vilken industrisektor ett bolag tillhör har betydelse. Den teori som främst förklarar frivillig redovisning om anställda är agentteorin.  Förslag till fortsatt forskning: I denna studie upptäckte vi att bolag redovisar fler kategorier om anställda än vad vi i vår studie deducerat fram från tidigare forskning. En kvalitativ kartläggning av kategorierna kan därför vara ett förslag till fortsatt forskning.  Uppsatsens bidrag: Mycket av tidigare forskning när det gäller frivillig redovisning har haft ett generellt fokus, där flera olika kategorier information som berör socialt ansvar (CSR) har använts och mycket av den har berört miljö eller finansiell information. Denna studie däremot har fokus på vad bolag specifikt frivilligt redovisar om anställda och detta specifika fokus har inte tidigare utförts på stora bolag på Stockholmsbörsen.

Magistro baigiamajame darbe bus išanalizuoti Lietuvos farmakologinio budrumo reglamentavimo pasikeitimai, iškeltos nepageidaujamų reakcijų ar kitų su vaistiniu preparatu susijusių kėblumų nustatymo, vertinimo ir pranešimo problemos bei pateikti siūlymai, kaip šias problemas spręsti. Pirmoje darbo dalyje teoriniu požiūriu bus tiriamas farmakologinis budrumas lietuvoje. Antroje dalyje bus nagrinėjamas atliktas tyrimas, kuriuo norima išsiaiškinti dėl kokių dažniausių nepageidaujamų reakcijų pacientai kreipiasi. / Master's thesis will analyze changes of pharmacovigilance regulatory in Lithuania, brought adverse reactions or other drug-related embarrassment identification, assessment and reporting problems and give suggestions on how to address these issues. On first part will be studied theoretically pharmacovigilance in Lithuania. On second part will be examined the study, what are the adverese reactions in wich patients complain.

Background: Drug interactions resulting in adverse drug reactions (ADRs) represent a major health problem both for individuals and society in general. Post-marketing pharmacovigilance reporting databases with compiled individual case safety reports (ICSRs) have been shown to be particularly useful in the detection of novel drug - ADR combinations, though these reports have not been fully used to detect adverse drug interactions. Aim: To explore the potential to identify drug interactions using ICSRs and to develop a method to facilitate the detection of adverse drug interaction signals in the WHO Global ICSR Database, VigiBase. Methods: All six studies included in this thesis are based on ICSRs available in VigiBase. Two studies aimed to characterise drug interactions reported in VigiBase. In the first study we examined if contraindicated drug combinations (given in a reference source of drug interactions) were reported on the individual reports in the database, and in the second study we examined the scientific literature for interaction mechanisms for drug combinations most frequently co-reported as interacting in VigiBase. Two studies were case series analyses where the individual reports were manually reviewed. The two remaining studies aimed to develop a method to facilitate detection of novel adverse drug interactions in VigiBase. One examined what information (referred to as indicators) was reported on ICSRs in VigiBase before the interactions became listed in the literature. In the second methodological study, logistic regression was used to set the relative weights of the indicators to form triage algorithms. Three algorithms (one completely data driven, one semi-automated and one based on clinical knowledge) based on pharmacological and reported clinical information and the relative reporting rate of an ADR with a drug combination were developed. The algorithms were then evaluated against a set of 100 randomly selected case series with potential adverse drug interactions. The algorithm’s performances were then evaluated among DDAs with high coefficients. Results: Drug interactions classified as contraindicated are reported on the individual reports in VigiBase, although they are not necessarily recognised as interactions when reported. The majority (113/123) of drug combinations suspected for being responsible for an ADR were established drug interactions in the literature. Of the 113 drug interactions 46 (41%) were identified as purely pharmacodynamic; 28 (25%) as pharmacokinetic; 18 (16%) were a mix of both types and for 21 (19%) the mechanism have not yet been identified. Suspicions of a drug interaction explicitly noted by the reporter are much more common for known adverse drug interactions than for drugs not known to interact. The clinical evaluation of the triage algorithms showed that 20 were already known in the literature, 30 were classified as signals and 50 as not signals. The performance of the semi-automated and the clinical algorithm were comparable. In the end the clinical algorithm was chosen. At a relevant level, 38% were of the adverse drug interactions were already known in the literature and of the remaining 80% were classified as signals for this algorithm. Conclusions: This thesis demonstrated that drug interactions can be identified in large post-marketing pharmacovigilance reporting databases. As both pharmacokinetic and pharmacodynamic interactions were reported on ICSRs the surveillance system should aim to detect both. The proposed triage algorithm had a high performance in comparison to the disproportionality measure alone.

Univ., Diss.--Augsburg, 2005.

Made available in DSpace on 2014-06-11T19:23:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-12-01Bitstream added on 2014-06-13T20:30:30Z : No. of bitstreams: 1 costa_ecmv_me_mar.pdf: 445805 bytes, checksum: 7a3d2f2b89e79e0cf15959db8f38ce28 (MD5) / O Poder Familiar é considerado a soma de direitos e obrigações assumidas pelos pais ou responsáveis legais, instituído com o objetivo de garantir a proteção legal dos interesses de subsistência, saúde e de educação dos filhos. Referido poder é atribuído aos pais pelo Estado e este é fiscalizador do exercício legal do mesmo. Ao Estado compete fiscalizar e controlar a relação entre as partes integrantes do Poder Familiar (pais e filhos), para que os direitos e deveres sejam cumpridos, sem desrespeito aos ditames da lei e os seus limites. Para efetivação deste estudo, a metodologia utilizada foi a História Oral, em que se buscou por meio de relatos registrados pelo gravador, verificar a representação que os operadores do direito têm a respeito dos problemas que culminam na destituição do Poder Familiar, bem como a conseqüente política judiciária na comarca de Marília. Ressaltou-se ainda as significativas alterações legislativas em que o poder antes concedido apenas ao pai (Pátrio Poder) passou a ser exercido igualmente pelo pai e mãe (Poder Familiar). Alterações estas que decorrem da transição de comportamentos e valores (modernidade), ocasionado pela modernização. Por fim, analisou-se o discurso jurídico dos entrevistados à luz das construções das relações de gênero. / The Familiar Discretion is considered the sum of rights and obligations assumed by parents or guardians of law, established with the objective of ensuring the legal protection of the interests of subsistence, health and childcare. Said power is given to parents by the state and this is the lawful exercise of supervisory the same. State falls to monitor and control the relationship between the parts of the Power family (parents and children), so that the rights and obligations are met, without disrespect to the dictates of the law and its limits. To accomplish this study, the methodology was the Oral History, which sought by reports recorded by the recorder, check the representation that the operators have the right to respect for the problems that culminate in the dismissal of Power Family, and the consequent Judicial politics in the district of Newark. It was also underscored the significant legislative changes in the power granted just before the father (vernacular Power) came to be exercised equally by the father and mother (Family Power). These changes arising from the transition of behaviors and values (modernity), caused by modernization. Finally, analyzed both the legal discourse of those interviewed in light of the construction of gender relations.

abstract: Since the 1988 uprising, a transnational advocacy network has formed around the issue of democracy and human rights in Burma. Within this transnational advocacy network, personal narratives of trauma have been promulgated in both international and oppositional news media and human rights reports. My thesis critically analyzes the use of the trauma narrative for advocacy purposes by the transnational advocacy network that has emerged around Burma and reveals the degree to which these narratives adhere to a Western, individualistic meta-narrative focused on political and civil liberties. Examining the "boomerang" pattern and the concept of marketability of movements, I highlight the characteristics of the 1988 uprising and subsequent opposition movement that attracted international interest. Reflecting on the psychological aspects of constructing trauma narratives, I then review the scholarship which links trauma narratives to social and human rights movements. Using a Foucauldian approach to discourse analysis, I subsequently explain my methodology in analyzing the personal narratives I have chosen. Beyond a theoretical discussion of trauma narratives and transnational advocacy networks, I analyze the use of personal narratives of activists involved in the 1988 uprising and the emergence of Aung San Suu Kyi's life story as a compelling narrative for Western audiences. I then explore the structure of human rights reports which situate personal narratives of trauma within the framework of international human rights law. I note the differences in the construction of traumatic narratives of agency and those of victimization. Finally, using Cyclone Nargis as a case study, I uncover the discursive divide between human rights and humanitarian actors and their use of personal narratives to support different discursive constructions of the aid effort in the aftermath of the cyclone. I conclude with an appeal to a more reflexive approach to advocacy work reliant on trauma narratives and highlight feminist methodologies that have been successful in bringing marginalized narratives to the center of human rights discussions. / Dissertation/Thesis / M.A. Social Justice and Human Rights 2011

Cette thèse a pour objectif d’expliquer pourquoi l’insertion de comptes-rendus de perception ou CRP dans un fragment narratif, lorsqu’elle entraîne une rupture dans la progression thématique de ce fragment, ne compromet pas sa compréhension.Les études narratologiques (Hamon, Adam et Petitjean) définissent les textes descriptifs comme des séquences qui se caractérisent par des marqueurs d’introduction et de clôture corrélés. Les études sur l’accès cognitif à l’information (Vogeleer) montrent, par ailleurs, que les CRP décrivent une situation accessible dans la situation spatio-temporelle d’un sujet. Ce sont des énoncés thétiques qui se caractérisent par leur absence de thème (Furukawa). A l’écrit, le contexte gauche d’un CRP peut compenser son absence de thème en décrivant une situation qui permet d’inférer le lieu cible de perception (Emma s’approcha de la fenêtre) d’un sujet introduit en amont. Les énoncés de ce type sont ainsi apparentés au DIL.La classification d’un corpus de CRP intégrant les noms fenêtre(s) et porte(s), nous a conduit à distinguer six types de CRP parmi lesquels les séquences de compte rendu de perception indirect libre ou CRPIL sont les plus fréquentes. Dans ces séquences, lorsque le premier CRP de l’extrait n’a aucun lien avec son contexte gauche, il décrit une situation perçue accessible dans la situation spatio-temporelle du sujet qui la perçoit, qui est donc inédite jusqu’à son introduction dans le monde fictif. La coïncidence spatio-temporelle entre le sujet et cette situation peut être dénotée dans certains extraits par un SP spatial ou temporel antéposé dans le premier CRP de la séquence et potentiellement cadratif (Charolles). Ce SP signale le point de vue du sujet introduit en amont, dénote le lieu cible ou la localisation temporelle de la situation décrite dans le CRP et permet d’interpréter tous les CRP de la séquence. Dans les extraits ne mentionnant pas de SP, le lieu cible et le temps de la situation perçue sont inférés dès l’introduction du premier CRP, cette inférence validant tous les CRP de la séquence. La rupture topicale suscitée par l’introduction des CRP signale, dans tous les cas, l’émergence du point de vue d’un personnage introduit en amont. / The aim of this thesis is to explain why the inclusion of perceptual reports (PRs) in a literary narrative does not interfere with the comprehension of such narratives, despite when breaking their thematic progression.Narratological studies (Hamon, Adam and Petitjean) define descriptive texts as sequences characterised by correlated introductory and closing markers. Furthermore, research on evidentiality (Vogeleer) shows that PR describe a situation that is accessible in the space/time situation of a subject. PRs are thetics statements characterised by a lack of topic (Furukawa). In the written form, the left context of the PR may make up for the lack of topic by describing a situation that may be used to infer the place targeted by the perception (Emma s’approcha de la fenêtre) of a subject introduced earlier. Statements of this type are thus similar to represented speech and thought or RST.The classification of a corpus of PRs incorporating the nouns fenêtre(s) and porte(s), leads us to distinguish six PRs types among which represented perceptual reports (RPRs), are most frequent. In these sequences, when the first PR of the excerpt has no link to its left context, it describes a perceived situation accessible in the spatial/temporal situation of the subject that perceives it, which is therefore unknown until introduced into the fictitious world. The spatial and temporal coincidence of the subject and this situation may be noted in certain excerpts by a spatial or temporal prepositional phrase (PP) that is placed earlier in the first PR of the sequence and that is potentially framing (Charolles). This PP signals the point of view of the subject introduced earlier, denotes the target location or temporal location of the situation described in the PR and makes it possible to interpret all the PRs in the sequence. In the excerpts that do not mention a PP, the target location and time of the perceived situation are inferred once the first PR is introduced, with this inference validating all perceptual reports in the sequence. The topical break caused by the introduction of PRs signals, in all cases, the emergence of the point of view of a character introduced earlier.

O presente estudo teve por objetivo explorar os diferentes estilos de conversa interna (CI) ou reflexividade, definidos como comunicativo, autônomo, metarreflexivo, e fraturado. Os autorrelatos da experiência da conversa interna foram obtidos por entrevistas com sete mulheres e três homens, de formações e ocupações diversificadas, com idade variando entre 24 e 63 anos. Os relatos foram analisados e interpretados de acordo com a orientação fenomenológica. A descrição focalizou a apreensão do fenômeno em uma estrutura simples e básica de um agente primário (capacitações cognitivas gerais e compartilhadas): quando ocorre, como se realiza, sobre quais conteúdos, para que serve e em que ajuda. A redução apontou três especificações de um agente corporativo (organizado e articulado): 1) quanto à experiência em si (comum, natural, habitual); 2) quanto à generalidade e à normalidade (não seria coisa de louco)? e 3) quanto à forma (se metódica e organizada; se espontânea e quase inconsciente). Interpretou-se que os modos de reflexividade, enquanto traslados qualitativos interculturais e atemporais sustentam-se em sua replicabilidade, com possíveis variações em implementações, preferências e manifestações. / This study intended to explore the different styles of internal conversation (IC) or reflexivity, defined as communicative, autonomous, meta-reflexive, and fractured. The self-reported experiences of internal conversation were obtained by interviewing seven women and three men of diverse backgrounds and occupations, aged between 24 and 63 years. The self-reported experiences were analyzed and interpreted in accordance with the phenomenological orientation. The description focused on understanding the phenomenon in a simple and basic structure of a primary agent (general and shared thinking skills): when it happens, how it happens, what are its contents, what purpose it serves and in which way it is helpful. The reduction pointed to three specifications of a corporate agent (organized and articulated): 1) in regards to the experience itself (common, natural, habitual); 2) whether it is general and normal (isn’t it something crazy?), and 3) regarding its form (is it methodical and organized or spontaneous and almost unconscious?). It was inferred from this study that the styles of reflexivity, while having inter-cultural and timeless qualities, are sustained in their universality, with possible variations in implementations, preferences and manifestations.

Purpose This paper analyses the use of marketing metrics and marketing information and metrics contained in 2006/7 annual reports of companies listed on the Johannesburg Stock Exchange. The assumption is that the annual reports are the vehicle whereby listed companies communicate to their shareholders and other stakeholder constituencies. Methodology The assessment criteria is based on Ambler’s (2003) suggested marketing metrics and qualitative data is based on a checklist compiled from various academic sources. The elements which are assessed pertain to brand equity, other customer metrics, segmentation, competition, innovation and environmental and strategic aspects. The information obtained is compared to information required by investors and rating is done based on a grand total maturity. Findings Research results indicate that the use of quantitative metrics and qualitative data is very limited. The majority of companies display a lack of information pertaining to marketing. The results reflect a bi-modal tendency. Half (53%) of the companies do not provide any or poor information on their brand whereas 26% of companies supplied good and excellent information. The grand total score indicates that nearly two thirds (60%) of companies obtain a score of less than 50%, providing insufficient information. On the other hand, 27% of companies provide good and excellent information. Segmentation metrics are generally not reflected in annual reports, neither are competitors. Innovation and environmental aspects influencing market trends are covered by two thirds, however a third provides insufficient information. Other findings include that no standard reporting format exists. Information pertaining to marketing is spread throughout the annual reports. None of the companies provide a glossary of marketing definition or brand terminology. Research implications More in-depth research needs to be conducted on various industry sectors and amongst investors as to their needs. Originality/ value The paper is of value to corporate executives, marketing and communication practitioners who seek to improve communication and to convey optimal information for the investment community. The aim is to stimulate executive management to revise their relationship towards customers, the brand, marketing strategy and investors. / Graduate School of Business Leadership / MBL